{"id":83921,"date":"2021-08-21T03:40:59","date_gmt":"2021-08-21T03:40:59","guid":{"rendered":"http:\/\/pingtungtimes.com.tw\/?p=83921"},"modified":"2021-08-21T03:41:48","modified_gmt":"2021-08-21T03:41:48","slug":"%ef%bb%bf%e9%98%b2%e6%b2%bb%e7%97%85%e6%af%92%e6%87%89%e5%88%86%e3%80%80%e9%ab%94%e5%a4%96%e8%88%87%e9%ab%94%e5%85%a7%e5%85%a9%e9%80%94%ef%bc%81","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=83921","title":{"rendered":"\ufeff\u9632\u6cbb\u75c5\u6bd2\u61c9\u5206\u3000\u201c\u9ad4\u5916\u201d\u8207\u201c\u9ad4\u5167\u201d\u5169\u9014\uff01"},"content":{"rendered":"\n<p>\u3010\u674e\u91cd\u5fb7\uff0f\u5c08\u6b04\u5831\u5c0e2021\/08\/19\u3011\u3000<strong>\u91cd\u5fb7\u8acb\u6703\u53cb\u5171\u540c\u7814\u8b8048\u7bc7\u5916\u570b\u91ab\u5b78\u8ad6\u6587\uff01<\/strong>\u4eca\u5929\uff0c\u91cd\u5fb7\u5728\u672c\u6703(\u9ad8\u96c4\u5e02\u4e2d\u5c0f\u4f01\u696d\u5354\u6703)\u7684\u7fa4\u7d44\u4e2d\u8cbc\u6587\u5982\u4e0b\uff1a<\/p>\n\n\n\n<p>\u91cd\u5fb7\u6b63\u5728\u7814\u8b80\u4ee5\u4e0b\u9019\u4e00\u7bc7\u91cd\u8981\u7684\u8ad6\u6587\uff1a<a>\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408<\/a>\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)( <a href=\"https:\/\/journals.plos.org\/plospathogens\/article?fbclid=IwAR2znc1tk21X1c0NJW3YT_nphHFkXjWLTr7-a1SKyiALI_hUlbA_tdYqbLk&amp;id=10.1371\/journal.ppat.1001176\">https:\/\/journals.plos.org\/plospathogens\/article?fbclid=IwAR2znc1tk21X1c0NJW3YT_nphHFkXjWLTr7-a1SKyiALI_hUlbA_tdYqbLk&amp;id=10.1371\/journal.ppat.1001176<\/a> )\uff0c\u9019\u662f\u6709\u95dc\u65bc\u201c\u92c5\u96e2\u5b50\u201d\u53ef\u4ee5\u9632\u6cbb\u51a0\u72c0\u75c5\u6bd2\u7684\u6700\u91cd\u8981\u7684\u4e00\u500b\u7814\u7a76\u5831\u544a\uff0c\u56e0\u6b64\uff0c\u91cd\u5fb7 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<\/a>\u300c\u4f0a\u7dad\u83cc\u7d20\u300d\u767c\u73fe\u65bc1975\u5e74\uff0c\u4e26\u57281981\u5e74\u5217\u70ba\u85e5\u7269\u30022015\u5e74\u5ea6\u7684\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u7684\u4e00\u534a\u806f\u5408\u6388\u4e88\u300c\u4f0a\u7dad\u83cc\u7d20\u300d\u767c\u73fe\u8005\u574e\u8c9d\u723e\u548c\u5927\u6751\uff0c\u7406\u7531\u662f\u300c\u9019\u7a2e\u884d\u751f\u7269\u5f9e\u6839\u672c\u4e0a\u964d\u4f4e\u4e86\u6cb3\u76f2\u75c7\u548c\u6dcb\u5df4\u7d72\u87f2\u75c5\uff08\u300c\u8c61\u76ae\u75c5<a>\u300d<\/a>\uff09\u7684\u767c\u75c5\u7387\uff0c\u4ee5\u53ca\u6709\u6548\u5c0d\u6297\u5feb\u901f\u589e\u52a0\u4e2d\u7684\u5176\u4ed6\u5bc4\u751f\u87f2\u75be\u75c5\u300d\u3002<\/p>\n\n\n\n<p> &nbsp;\u300c\u4f0a\u7dad\u83cc\u7d20<a>\u300d<\/a>\u7684\u5316\u5b78\u5f0f\uff1a\u3010C<sub>48<\/sub>H<sub>74<\/sub>O<sub>14(22,23-dihydroavermectin B=1a)<\/sub>\u53caC<sub>47<\/sub>H<sub>72<\/sub>O<sub>14<\/sub>(22,23-dihydroavermectin B=1b)\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a<\/p>\n\n\n\n<p><a><strong>\u300c<\/strong><\/a><strong>\u4f0a\u7dad\u83cc\u7d20\u300d\u5728\u9ad4\u5916\u5c0d\u5305\u62ecSARS-CoV-2\u5728\u5167\u7684\u82e5\u5e72\u6b63\u55ae\u93c8RNA\u75c5\u6bd2\u6709\u6297\u75c5\u6bd2\u4f5c\u7528<\/strong>\uff0c\u5176\u534a\u6291\u5236\u6fc3\u5ea6\u70ba2.2\u20132.8\u03bcM\u3002<\/p>\n\n\n\n<p><strong>\u4f46\u662f\uff0c\u300c\u4f0a\u7dad\u83cc\u7d20<a>\u300d<\/a>\u5728\u4eba\u9ad4\u5167\u9054\u5230\u6297\u75c5\u6bd2\u4f5c\u7528\u6240\u9700\u5291\u91cf\u9060\u9ad8\u65bc\u4eba\u7528\u6700\u9ad8\u6279\u51c6\u5291\u91cf\u3001\u4ea6\u8d85\u904e\u53ef\u5b89\u5168\u5be6\u73fe\u5291\u91cf\u3002<\/strong>\u610f\u5373\u672c\u85e5\u901a\u904e\u6291\u5236\u8f38\u5165\u86cb\u767d\u03b1\/\u03b21\u7684\u6838\u904b\u8f38\u9054\u5230\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u5728\u4e0a\u8ff0\u5291\u91cf\u4e0b\u5c0d\u5bbf\u4e3b\u6709\u6bd2\u3002\u9019\u5c31\u662f\u70ba\u4f55\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u8981\u8868\u793a\u672c\u85e5\u9664\u81e8\u5e8a\u8a66\u9a57\u5916\u4e0d\u61c9\u7528\u65bc\u6cbb\u7642COVID-19\u3002<\/p>\n\n\n\n<p>\u300c\u4f0a\u7dad\u83cc\u7d20\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u86cb\u767d\u7d50\u5408\u5ea6\u2500\u250093%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df(CYP450)\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u250018\u5c0f\u6642\uff1b\u6392\u6cc4\u2500\u2500\u7cde\u4fbf;\u5c3f\u6db2&lt;1%\u3002<\/p>\n\n\n\n<p>\u91cd\u5fb7\u8a8d\u70ba\u65e2\u7136\u300c\u4f0a\u7dad\u83cc\u7d20\u300d\u80fd\u5728\u9ad4\u5916\u5c0d\u5305\u62ecSARS-CoV-2\u5728\u5167\u7684\u82e5\u5e72\u6b63\u55ae\u93c8RNA\u75c5\u6bd2\u6709\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u56e0\u6b64\u5c0d\u65bc\u8207SARS\u75c5\u6bd2\u985e\u4f3c\u7684COVID-19\u75c5\u6bd2\u61c9\u8a72\u4e5f\u6703\u6709\u4e00\u5b9a\u7684\u6548\u679c\u3002\u4f46\u662f\u7531\u65bc\u5b83\u5df2\u7d93\u56e0\u70ba\u5c0d\u5bbf\u4e3b\u6709\u6bd2\u800c\u88ab\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u7981\u7528\u65bc\u6cbb\u7642COVID-19\uff0c\u56e0\u6b64\uff0c\u91cd\u5fb7 \u5c07\u66ab\u4e0d\u8003\u616e\u7528\u5176\u505a\u70ba\u904b\u9001<a>\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d<\/a>\u3002<\/p>\n\n\n\n<p><strong>\u300c\u7fa5\u6c2f\u594e\u5be7\u300d<a>\u80fd\u9632\u6cbb<\/a><a>COVID-19\u75c5\u6bd2<\/a>\u55ce\uff1f<\/strong><a>\u300c\u7fa5\u6c2f<\/a>\u55b9\u300d\uff08\u82f1\u8a9e\uff1ahydroxychloroquine\uff0c\u7e2e\u5beb\uff1aHCQ\uff09\uff0c\u5728\u81fa\u7063\u7a31\u70ba\u300c\u6c2b\u6c27\u594e\u5be7\u300d\u3001<a>\u300c<\/a>\u7fa5\u6c2f\u594e\u5be7<a>\u300d<\/a>\uff0c\u5728\u7627\u539f\u87f2\u5c0d\u300c\u6c2f\u55b9\u300d\u4ecd\u6709\u7642\u6548\u7684\u5730\u5340\uff0c\u543e\u4eba\u901a\u5e38\u6703\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u9810\u9632\u53ca\u6cbb\u7642\u300c\u7627\u75be\u300d\u3002<\/p>\n\n\n\n<p>\u6b64\u5916\uff0c<a>\u300c<\/a>\u7fa5\u6c2f\u55b9<a>\u300d<\/a>\u4e5f\u7528\u65bc\u6cbb\u7642\u300c\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u300d\u3001\u300c\u7d05\u6591\u6027\u72fc\u7621\u300d\u548c\u300c\u7de9\u767c\u6027\u76ae\u819a\u75c5\u8b8a\u7d2b\u8cea\u75c7\u300d\u3002\u4e5f\u662f\u61f7\u5b55\u671f\u9593\u98a8\u6fd5\u75c5\u7684\u6cbb\u7642\u7528\u85e5\u3002\u85e5\u7269\u5206\u985e\u4e2d\uff0c<a>\u300c<\/a>\u7fa5\u57fa\u6c2f\u55b9\u300d\u5c6c\u65bc\u6297\u7627\u85e5\u548c\u300c4-\u6c28\u57fa\u55b9\u5549\u300d\u3002<a>\u300c<\/a>\u7fa5\u6c2f\u55b9<a>\u300d<\/a>\u57281955\u5e74\u6838\u51c6\u65bc\u7f8e\u570b\u6cbb\u7642\u4f7f\u7528\u3002\u6b64\u85e5\u540d\u5217\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u57fa\u672c\u85e5\u7269\u6a19\u6e96\u6e05\u55ae\uff0c\u610f\u5373\u8a8d\u53ef\u70ba\u91ab\u7642\u7cfb\u7d71\u4e2d\u6700\u6709\u6548\u4e14\u5b89\u5168\u7684\u5fc5\u5099\u85e5\u7269\u3002<\/p>\n\n\n\n<p>\u300c\u6b50\u6d32\u98a8\u6fd5\u75c5\u806f\u76df\u300d\u65bc2012\u5e74\u767c\u5e03\u7684\u300c\u72fc\u7621\u6027\u814e\u708e\u300d (lupus nephritis\u3001LN) \u6cbb\u7642\u6307\u5357\uff0c\u5747\u5efa\u8b70\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70baLN\u7684\u57fa\u790e\u6cbb\u7642\u7528\u85e5\u3002<\/p>\n\n\n\n<p>2020\u5e745\u670825\u65e5<a>\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f<\/a>\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642<a>\u300c<\/a>\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n\n\n\n<p>\u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u5316\u5b78\u5f0f\u662f\u3010C<sub>18<\/sub>H<sub>26<\/sub>ClN<sub>3<\/sub>O\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747-1.png\" alt=\"\" class=\"wp-image-83927\" width=\"843\" height=\"440\" srcset=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747-1.png 875w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747-1-150x79.png 150w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747-1-300x157.png 300w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747-1-768x402.png 768w\" sizes=\"auto, (max-width: 843px) 100vw, 843px\" \/><\/figure>\n\n\n\n<p>\u300c\u7fa5\u6c2f\u55b9\u300d\u7684<a>\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a<\/a>\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747 74%(<a href=\"https:\/\/zh.wikipedia.org\/w\/index.php?title=%E5%B3%B0%E6%BF%83%E5%BA%A6&amp;action=edit&amp;redlink=1\">T<sub>max<\/sub><\/a>&nbsp;= 2\u20134.5\n\u5c0f\u6642)\uff1b\u86cb\u767d\u7d50\u5408\u5ea6\u2500\u2500&nbsp;&nbsp;&nbsp; 45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002<\/p>\n\n\n\n<p>\u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f<a>\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684<\/a><a>\u201c\u8f09\u9ad4\u201d<\/a>\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b<a>\u6fa4\u9023\u79d1\u535a\u58eb<\/a>\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\uff0c\u76ee\u524d\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c<a>\u300c\u7fa5\u6c2f<\/a>\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u91cd\u5fb7 \u96d6\u7136\u8a8d\u70ba\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u7684\u5224\u65b7\u6709\u8aa4\u6216\u662f\u5225\u6709\u7528\u5fc3\uff0c\u4f46\u662f\uff0c\u986f\u7136\u5df2\u7d93\u963b\u65b7\u4e86\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u9632\u6cbbCOVID-19\u75c5\u6bd2\u7684\u7814\u7a76\u4e4b\u8def\u3002<\/p>\n\n\n\n<p><a><strong>\u300c\u5967\u9ea5\u4e01\u92c5\u300d<\/strong><\/a><strong>\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f<\/strong><a>\u300c<\/a>\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba<a>\u300c<\/a>\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72<a>\u300d<\/a>\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba<a>\u300c<\/a>\u53bb\u5c51\u56e0\u5b50\u300d\u3002<\/p>\n\n\n\n<p><a>\u300c<\/a>\u5967\u9ea5\u4e01\u92c5<a>\u300d<\/a>\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002<\/p>\n\n\n\n<p><a>\u300c<\/a>\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1&#8242;-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C<sub>10<\/sub>H<sub>8<\/sub>N<sub>2<\/sub>O<sub>2<\/sub>S<sub>2<\/sub>Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728-1.png\" alt=\"\" class=\"wp-image-83925\" width=\"840\" height=\"416\" srcset=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728-1.png 800w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728-1-150x74.png 150w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728-1-300x149.png 300w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728-1-768x380.png 768w\" sizes=\"auto, (max-width: 840px) 100vw, 840px\" \/><\/figure>\n\n\n\n<p><a>\u300c<\/a>\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/1-3.png\" alt=\"\" class=\"wp-image-83926\" width=\"841\" height=\"841\" srcset=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/1-3.png 875w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/1-3-150x150.png 150w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/1-3-300x300.png 300w, https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2021\/08\/1-3-768x768.png 768w\" sizes=\"auto, (max-width: 841px) 100vw, 841px\" \/><\/figure>\n\n\n\n<p>\u4f46\u662f\uff0c<a>\u300c<\/a>\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002<\/p>\n\n\n\n<p><a>\u300c<\/a>\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc<a>\u300d<\/a>\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002<\/p>\n\n\n\n<p>\u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+\nInhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc\nIonophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a<\/p>\n\n\n\n<p>\u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M\nZn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d<a>\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) <\/a>\u7684\u8907\u5236\u3002<\/p>\n\n\n\n<p>\u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 <a>RTC<\/a> \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002<\/p>\n\n\n\n<p>\u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7\nEAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002<\/p>\n\n\n\n<p>\u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002<\/p>\n\n\n\n<p>\u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002<\/p>\n\n\n\n<p>References\u53c3\u8003\u6587\u737b<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Lazarczyk\n     M, Favre M (2008) Role of Zn<sup>2+<\/sup>&nbsp;ions in host-virus interactions. J Virol\n     82: 11486\u201311494.&nbsp;&nbsp;&nbsp; \u30081. Lazarczyk M, Favre M (2008) Zn2+ \u96e2\u5b50\u5728\u5bbf\u4e3b-\u75c5\u6bd2\u76f8\u4e92\u4f5c\u7528\u4e2d\u7684\u4f5c\u7528\u3002 J Virol 82\uff1a11\u200b\u200b486\u201311494\u3002\u3009<ul><li><a href=\"https:\/\/journals.plos.org\/plospathogens\/article?fbclid=IwAR2znc1tk21X1c0NJW3YT_nphHFkXjWLTr7-a1SKyiALI_hUlbA_tdYqbLk&amp;id=10.1371\/journal.ppat.1001176\">View Article<\/a><\/li><li><a href=\"http:\/\/scholar.google.com\/scholar?q=Role+of+Zn2%2B+ions+in+host-virus+interactions.+Lazarczyk+2008\">Google Scholar<\/a><\/li><\/ul><\/li><li>Frederickson\n     CJ, Koh JY, Bush AI (2005) Neurobiology of zinc in health and disease. Nat\n     Rev Neurosci 6: 449\u2013462.&nbsp;&nbsp;&nbsp; \u30082.\n     Frederickson CJ\u3001Koh JY\u3001Bush\n     AI (2005) \u92c5\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u795e\u7d93\u751f\u7269\u5b78\u3002 Nat Rev Neurosci 6\uff1a449-462\u3002\u3009<ul><li><a href=\"https:\/\/journals.plos.org\/plospathogens\/article?fbclid=IwAR2znc1tk21X1c0NJW3YT_nphHFkXjWLTr7-a1SKyiALI_hUlbA_tdYqbLk&amp;id=10.1371\/journal.ppat.1001176\">View Article<\/a><\/li><li><a href=\"http:\/\/scholar.google.com\/scholar?q=Neurobiology+of+zinc+in+health+and+disease.+Frederickson+2005\">Google Scholar<\/a><\/li><\/ul><\/li><li>Alirezaei\n     M, Nairn AC, Glowinski J, Premont J, Marin P (1999) Zinc inhibits protein\n     synthesis in neurons: potential rol of phosphorylation of translation\n     initiation factor-2a. J Biol Chem 274: 32433\u201332438.&nbsp;&nbsp;&nbsp; \u30083. Alirezaei\n     M\u3001Nairn AC\u3001Glowinski J\u3001Premont J\u3001Marin P (1999) \u92c5\u6291\u5236\u795e\u7d93\u5143\u4e2d\u7684\u86cb\u767d\u8cea\u5408\u6210\uff1a\u7ffb\u8b6f\u8d77\u59cb\u56e0\u5b50 2a \u78f7\u9178\u5316\u7684\u6f5b\u5728\u4f5c\u7528\u3002\u751f\u7269\u5316\u5b78\u96dc\u8a8c 274\uff1a32433\u201332438\u3002\u3009<ul><li><a href=\"https:\/\/journals.plos.org\/plospathogens\/article?fbclid=IwAR2znc1tk21X1c0NJW3YT_nphHFkXjWLTr7-a1SKyiALI_hUlbA_tdYqbLk&amp;id=10.1371\/journal.ppat.1001176\">View Article<\/a><\/li><li><a href=\"http:\/\/scholar.google.com\/scholar?q=Zinc+inhibits+protein+synthesis+in+neurons%3A+potential+rol+of+phosphorylation+of+translation+initiation+factor-2a.+Alirezaei+1999\">Google Scholar<\/a><\/li><\/ul><\/li><li>Uchide N,\n     Ohyama K, Bessho T, Yuan B, Yamakawa T (2002) Effect of antioxidants on\n     apoptosis induced by influenza virus infection: inhibition of viral gene\n     replication and transcription with pyrrolidine dithiocarbamate. Antiviral\n     Res 56: 207\u2013217.&nbsp;&nbsp;&nbsp; \u30084. 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Scholar<\/a><\/li><\/ul><\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u25bc\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002\uff08\u5716\uff0f\u674e\u91cd\u5fb7\u63d0\u4f9b\uff09<\/p>\n","protected":false},"author":1,"featured_media":83928,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[11],"tags":[28339,9360,28338],"class_list":["post-83921","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-11","tag-28339","tag-9360","tag-28338"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002  \u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b\u6fa4\u9023\u79d1\u535a\u58eb\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002  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\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba\u300c\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72\u300d\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba\u300c\u53bb\u5c51\u56e0\u5b50\u300d\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1&#039;-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C10H8N2O2S2Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a    \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a    \u4f46\u662f\uff0c\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc\u300d\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002  \u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a  \u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M Zn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) \u7684\u8907\u5236\u3002  \u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 RTC \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002  \u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7 EAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002  \u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002  \u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002  References\u53c3\u8003\u6587\u737b  Lazarczyk   M, Favre M (2008) Role of Zn2+&nbsp;ions in host-virus interactions. J Virol   82: 11486\u201311494.&nbsp;&nbsp;&nbsp; \u30081. Lazarczyk M, Favre M (2008) Zn2+ \u96e2\u5b50\u5728\u5bbf\u4e3b-\u75c5\u6bd2\u76f8\u4e92\u4f5c\u7528\u4e2d\u7684\u4f5c\u7528\u3002 J Virol 82\uff1a11\u200b\u200b486\u201311494\u3002\u3009View ArticleGoogle ScholarFrederickson   CJ, Koh JY, Bush AI (2005) Neurobiology of zinc in health and disease. Nat   Rev Neurosci 6: 449\u2013462.&nbsp;&nbsp;&nbsp; \u30082.   Frederickson CJ\u3001Koh JY\u3001Bush   AI (2005) \u92c5\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u795e\u7d93\u751f\u7269\u5b78\u3002 Nat Rev Neurosci 6\uff1a449-462\u3002\u3009View ArticleGoogle ScholarAlirezaei   M, Nairn AC, Glowinski J, Premont J, Marin P (1999) Zinc inhibits protein   synthesis in neurons: potential rol of phosphorylation of translation   initiation factor-2a. J Biol Chem 274: 32433\u201332438.&nbsp;&nbsp;&nbsp; \u30083. 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content=\"\u3010\u674e\u91cd\u5fb7\uff0f\u5c08\u6b04\u5831\u5c0e2021\/08\/19\u3011\u3000\u91cd\u5fb7\u8acb\u6703\u53cb\u5171\u540c\u7814\u8b8048\u7bc7\u5916\u570b\u91ab\u5b78\u8ad6\u6587\uff01\u4eca\u5929\uff0c\u91cd\u5fb7\u5728\u672c\u6703(\u9ad8\u96c4\u5e02\u4e2d\u5c0f\u4f01\u696d\u5354\u6703)\u7684\u7fa4\u7d44\u4e2d\u8cbc\u6587\u5982\u4e0b\uff1a  \u91cd\u5fb7\u6b63\u5728\u7814\u8b80\u4ee5\u4e0b\u9019\u4e00\u7bc7\u91cd\u8981\u7684\u8ad6\u6587\uff1a\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)( 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45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002  \u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b\u6fa4\u9023\u79d1\u535a\u58eb\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002  \u4f46\u662f\uff0c\u76ee\u524d\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u91cd\u5fb7 \u96d6\u7136\u8a8d\u70ba\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u7684\u5224\u65b7\u6709\u8aa4\u6216\u662f\u5225\u6709\u7528\u5fc3\uff0c\u4f46\u662f\uff0c\u986f\u7136\u5df2\u7d93\u963b\u65b7\u4e86\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u9632\u6cbbCOVID-19\u75c5\u6bd2\u7684\u7814\u7a76\u4e4b\u8def\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba\u300c\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72\u300d\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba\u300c\u53bb\u5c51\u56e0\u5b50\u300d\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1&#039;-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C10H8N2O2S2Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a    \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a    \u4f46\u662f\uff0c\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc\u300d\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002  \u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a  \u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M Zn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) \u7684\u8907\u5236\u3002  \u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 RTC \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002  \u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7 EAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002  \u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002  \u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002  References\u53c3\u8003\u6587\u737b  Lazarczyk   M, Favre M (2008) Role of Zn2+&nbsp;ions in host-virus interactions. 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\u6b64\u5916\uff0c\u300c\u7fa5\u6c2f\u55b9\u300d\u4e5f\u7528\u65bc\u6cbb\u7642\u300c\u985e\u98a8\u6fd5\u6027\u95dc\u7bc0\u708e\u300d\u3001\u300c\u7d05\u6591\u6027\u72fc\u7621\u300d\u548c\u300c\u7de9\u767c\u6027\u76ae\u819a\u75c5\u8b8a\u7d2b\u8cea\u75c7\u300d\u3002\u4e5f\u662f\u61f7\u5b55\u671f\u9593\u98a8\u6fd5\u75c5\u7684\u6cbb\u7642\u7528\u85e5\u3002\u85e5\u7269\u5206\u985e\u4e2d\uff0c\u300c\u7fa5\u57fa\u6c2f\u55b9\u300d\u5c6c\u65bc\u6297\u7627\u85e5\u548c\u300c4-\u6c28\u57fa\u55b9\u5549\u300d\u3002\u300c\u7fa5\u6c2f\u55b9\u300d\u57281955\u5e74\u6838\u51c6\u65bc\u7f8e\u570b\u6cbb\u7642\u4f7f\u7528\u3002\u6b64\u85e5\u540d\u5217\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u57fa\u672c\u85e5\u7269\u6a19\u6e96\u6e05\u55ae\uff0c\u610f\u5373\u8a8d\u53ef\u70ba\u91ab\u7642\u7cfb\u7d71\u4e2d\u6700\u6709\u6548\u4e14\u5b89\u5168\u7684\u5fc5\u5099\u85e5\u7269\u3002 \u300c\u6b50\u6d32\u98a8\u6fd5\u75c5\u806f\u76df\u300d\u65bc2012\u5e74\u767c\u5e03\u7684\u300c\u72fc\u7621\u6027\u814e\u708e\u300d (lupus nephritis\u3001LN) \u6cbb\u7642\u6307\u5357\uff0c\u5747\u5efa\u8b70\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70baLN\u7684\u57fa\u790e\u6cbb\u7642\u7528\u85e5\u3002 2020\u5e745\u670825\u65e5\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002 \u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u5316\u5b78\u5f0f\u662f\u3010C18H26ClN3O\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a \u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747 74%(Tmax&nbsp;= 2\u20134.5 \u5c0f\u6642)\uff1b\u86cb\u767d\u7d50\u5408\u5ea6\u2500\u2500&nbsp;&nbsp;&nbsp; 45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002 \u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b\u6fa4\u9023\u79d1\u535a\u58eb\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002 \u4f46\u662f\uff0c\u76ee\u524d\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u91cd\u5fb7 \u96d6\u7136\u8a8d\u70ba\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u7684\u5224\u65b7\u6709\u8aa4\u6216\u662f\u5225\u6709\u7528\u5fc3\uff0c\u4f46\u662f\uff0c\u986f\u7136\u5df2\u7d93\u963b\u65b7\u4e86\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u9632\u6cbbCOVID-19\u75c5\u6bd2\u7684\u7814\u7a76\u4e4b\u8def\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba\u300c\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72\u300d\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba\u300c\u53bb\u5c51\u56e0\u5b50\u300d\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1'-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C10H8N2O2S2Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a \u4f46\u662f\uff0c\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc\u300d\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002 \u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a \u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M Zn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) \u7684\u8907\u5236\u3002 \u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 RTC \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002 \u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7 EAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002 \u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002 \u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002 References\u53c3\u8003\u6587\u737b Lazarczyk M, Favre M (2008) Role of Zn2+&nbsp;ions in host-virus interactions. J Virol 82: 11486\u201311494.&nbsp;&nbsp;&nbsp; \u30081. Lazarczyk M, Favre M (2008) Zn2+ \u96e2\u5b50\u5728\u5bbf\u4e3b-\u75c5\u6bd2\u76f8\u4e92\u4f5c\u7528\u4e2d\u7684\u4f5c\u7528\u3002 J Virol 82\uff1a11\u200b\u200b486\u201311494\u3002\u3009View ArticleGoogle ScholarFrederickson CJ, Koh JY, Bush AI (2005) Neurobiology of zinc in health and disease. Nat Rev Neurosci 6: 449\u2013462.&nbsp;&nbsp;&nbsp; \u30082. Frederickson CJ\u3001Koh JY\u3001Bush AI (2005) \u92c5\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u795e\u7d93\u751f\u7269\u5b78\u3002 Nat Rev Neurosci 6\uff1a449-462\u3002\u3009View ArticleGoogle ScholarAlirezaei M, Nairn AC, Glowinski J, Premont J, Marin P (1999) Zinc inhibits protein synthesis in neurons: potential rol of phosphorylation of translation initiation factor-2a. J Biol Chem 274: 32433\u201332438.&nbsp;&nbsp;&nbsp; \u30083. Alirezaei M\u3001Nairn AC\u3001Glowinski J\u3001Premont J\u3001Marin P (1999) \u92c5\u6291\u5236\u795e\u7d93\u5143\u4e2d\u7684\u86cb\u767d\u8cea\u5408\u6210\uff1a\u7ffb\u8b6f\u8d77\u59cb\u56e0\u5b50 2a \u78f7\u9178\u5316\u7684\u6f5b\u5728\u4f5c\u7528\u3002\u751f\u7269\u5316\u5b78\u96dc\u8a8c 274\uff1a32433\u201332438\u3002\u3009View ArticleGoogle ScholarUchide N, Ohyama K, Bessho T, Yuan B, Yamakawa T (2002) Effect of antioxidants on apoptosis induced by influenza virus infection: inhibition of viral gene replication and transcription with pyrrolidine dithiocarbamate. Antiviral Res 56: 207\u2013217.&nbsp;&nbsp;&nbsp; \u30084. 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45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002  \u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b\u6fa4\u9023\u79d1\u535a\u58eb\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002  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\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba\u300c\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72\u300d\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba\u300c\u53bb\u5c51\u56e0\u5b50\u300d\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1'-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C10H8N2O2S2Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a    \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a    \u4f46\u662f\uff0c\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc\u300d\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002  \u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a  \u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M Zn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) \u7684\u8907\u5236\u3002  \u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 RTC \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002  \u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7 EAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002  \u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002  \u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002  References\u53c3\u8003\u6587\u737b  Lazarczyk   M, Favre M (2008) Role of Zn2+&nbsp;ions in host-virus interactions. 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45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002  \u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b\u6fa4\u9023\u79d1\u535a\u58eb\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002  \u4f46\u662f\uff0c\u76ee\u524d\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u91cd\u5fb7 \u96d6\u7136\u8a8d\u70ba\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u7684\u5224\u65b7\u6709\u8aa4\u6216\u662f\u5225\u6709\u7528\u5fc3\uff0c\u4f46\u662f\uff0c\u986f\u7136\u5df2\u7d93\u963b\u65b7\u4e86\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u9632\u6cbbCOVID-19\u75c5\u6bd2\u7684\u7814\u7a76\u4e4b\u8def\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba\u300c\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72\u300d\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba\u300c\u53bb\u5c51\u56e0\u5b50\u300d\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1'-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C10H8N2O2S2Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a    \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a    \u4f46\u662f\uff0c\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002  \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc\u300d\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002  \u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a  \u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M Zn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) \u7684\u8907\u5236\u3002  \u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 RTC \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002  \u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7 EAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002  \u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002  \u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002  References\u53c3\u8003\u6587\u737b  Lazarczyk   M, Favre M (2008) Role of Zn2+&nbsp;ions in host-virus interactions. 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\u300c\u6b50\u6d32\u98a8\u6fd5\u75c5\u806f\u76df\u300d\u65bc2012\u5e74\u767c\u5e03\u7684\u300c\u72fc\u7621\u6027\u814e\u708e\u300d (lupus nephritis\u3001LN) \u6cbb\u7642\u6307\u5357\uff0c\u5747\u5efa\u8b70\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70baLN\u7684\u57fa\u790e\u6cbb\u7642\u7528\u85e5\u3002 2020\u5e745\u670825\u65e5\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002 \u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u5316\u5b78\u5f0f\u662f\u3010C18H26ClN3O\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a \u300c\u7fa5\u6c2f\u55b9\u300d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u6578\u64da\u5982\u4e0b\uff1a\u751f\u7269\u5229\u7528\u5ea6\u2500\u2500\u5e73\u5747 74%(Tmax&nbsp;= 2\u20134.5 \u5c0f\u6642)\uff1b\u86cb\u767d\u7d50\u5408\u5ea6\u2500\u2500&nbsp;&nbsp;&nbsp; 45%\uff1b\u4ee3\u8b1d\u2500\u2500\u809d\u81df\uff1b\u751f\u7269\u534a\u8870\u671f\u2500\u2500&nbsp;&nbsp;&nbsp; 32\u201350 \u5929\uff1b\u6392\u6cc4\u2500\u2500\u4e3b\u8981\u7531\u814e\u81df\uff0823\u201325% \u4ee5\u85e5\u7269\u539f\u578b\u6392\u51fa\uff09\uff0c\u81bd\u6c41\uff08&lt;10%\uff09\u3002 \u300c\u7fa5\u6c2f\u55b9\u300d\u4e4b\u6240\u4ee5\u88ab\u8996\u70ba\u662f\u53ef\u80fd\u7684\u201c\u92c5\u96e2\u5b50\u201d\u7684\u201c\u8f09\u9ad4\u201d\uff0c\u9019\u662f\u56e0\u70ba\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u5e2b\u6fa4\u9023\u79d1\u535a\u58eb\u57282020\u5e74\u7684\u81e8\u5e8a\u91ab\u7642\u4e2d\u63a1\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\u4f75\u540c\u201c\u92c5\u96e2\u5b50\u201d\u4f86\u70ba650\u4f4dCOVID-19\u7684\u65e9\u671f\u78ba\u8b49\u75c5\u60a3\u6cbb\u7642\u4e4b\u5f8c\uff0c\u767c\u73fe\u4e26\u7121\u4efb\u4f55\u75c5\u60a3\u8f49\u70ba\u91cd\u75c7\uff0c\u6fa4\u9023\u79d1\u535a\u58eb\u81ea\u5df1\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\u662f\u201c\u69cd\u201d(\u5373\u201c\u8f09\u9ad4\u201d)\uff0c\u800c\u201c\u92c5\u96e2\u5b50\u201d\u662f\u5b50\u5f48\u3002 \u4f46\u662f\uff0c\u76ee\u524d\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u5ba3\u5e03\uff0c\u66ab\u505c\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u6f5b\u5728\u6cbb\u7642\u300c\u65b0\u578b\u51a0\u72c0\u75c5\u6bd2\u300d\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u91cd\u5fb7 \u96d6\u7136\u8a8d\u70ba\u300c\u4e16\u754c\u885b\u751f\u7d44\u7e54\u300d\u7684\u5224\u65b7\u6709\u8aa4\u6216\u662f\u5225\u6709\u7528\u5fc3\uff0c\u4f46\u662f\uff0c\u986f\u7136\u5df2\u7d93\u963b\u65b7\u4e86\u300c\u7fa5\u6c2f\u55b9\u300d\u4f5c\u70ba\u9632\u6cbbCOVID-19\u75c5\u6bd2\u7684\u7814\u7a76\u4e4b\u8def\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u9632\u6cbbCOVID-19\u75c5\u6bd2\u55ce\uff1f\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6216\u88ab\u7a31\u70ba\u300c\u5421\u5576\u786b\u916e\u92c5\u300d\u6216\u7c21\u7a31\u70baZnP\uff0cZPT\u6216PTZ\uff0c\u662f\u4e00\u7a2e\u7121\u8272\u56fa\u9ad4\uff0c\u5728\u5e38\u6eab\u4e2d\u6027\u689d\u4ef6\u4e0b\u5e7e\u4e4e\u4e0d\u6eb6\u65bc\u6c34\u3002\u56e0\u70ba\u5e38\u88ab\u5927\u91cf\u61c9\u7528\u65bc\u300c\u6d77\u502b\u4ed9\u5ea6\u7d72\u300d\u7b49\u53bb\u982d\u76ae\u5c51\u6d17\u9aee\u7cbe\u4e4b\u4e2d\uff0c\u56e0\u6b64\u4e5f\u88ab\u7a31\u70ba\u300c\u53bb\u5c51\u56e0\u5b50\u300d\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u80fd\u4ee5\u4e0d\u8d85\u904e1.5%\u7684\u542b\u91cf\u52a0\u5165\u6d17\u9aee\u6c34\uff08\u666e\u901a\u300c\u6d77\u98db\u7d72\u6d17\u9aee\u6c34\u300d\u4e2d\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u6709\u6548\u6210\u5206\u542b\u91cf\u70ba1%\uff09\u7b49\u65e5\u7528\u5316\u5b78\u54c1\uff0c\u4f46\u662f\u5927\u5291\u91cf\u63a5\u89f8\u6216\u98df\u7528\u53ef\u80fd\u6703\u6709\u81f4\u547d\u5371\u96aa\uff08EU\u5206\u985eT+\uff09\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u7684IUPAC\u540d\u662f\u3010bis(2-pyridylthio)zinc 1,1'-dioxide\u3011\uff0c\u4e5f\u5c31\u662f\u3010\u96d9(2-\u786b\u4ee3-1-\u6c27\u5316\u5421\u5576)\u92c5\u3011\uff0c\u5176\u5316\u5b78\u5f0f\u662f\u3010C10H8N2O2S2Zn\u3011\uff0c\u5176\u5206\u5b50\u6392\u5217\u5982\u4e0b\u5716\uff1a \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u5e38\u4ee5\u4e8c\u805a\u9ad4\u5f62\u5f0f\u5b58\u5728\uff0c\u6bcf\u500b\u92c5\u96e2\u5b50\u8207\u5169\u500b\u786b\u548c\u4e09\u500b\u6c27\u4ee5\u56db\u65b9\u9310\u5f62\u5f0f\u914d\u5408\uff0c\u800c\u5f62\u6210\u4e0b\u5716\u7684\u5171\u8edb\u9e7c\u87af\u5408\u7269\u5206\u5b50\u6392\u5217\uff1a \u4f46\u662f\uff0c\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5728\u6eb6\u6db2\u4e2d\u4e8c\u805a\u9ad4\u56e0\u4e00\u500b\u6c27-\u92c5\u914d\u4f4d\u9375\u7684\u65b7\u958b\u800c\u89e3\u9ad4\u70ba\u5169\u500b\u55ae\u9ad4\u3002 \u300c\u5967\u9ea5\u4e01\u92c5\u300d\u662f\u826f\u597d\u7684\u6bba\u771f\u83cc\u5291\u548c\u6bba\u85fb\u5291\u3002\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u901a\u904e\u963b\u585e\u8cea\u5b50\u6cf5\u4f86\u5e72\u64fe\u7d30\u80de\u819c\u7684\u7269\u8cea\u8f49\u904b\u5de5\u4f5c\uff0c\u5176\u6700\u8457\u540d\u7684\u7528\u9014\u4fbf\u662f\u6cbb\u7642\u7531\u300c\u79d5\u7ce0\u99ac\u62c9\u766c\u83cc\u300d\u5f15\u8d77\u7684\u300c\u982d\u76ae\u5c51\u300d\u548c\u300c\u8102\u6ea2\u6027\u76ae\u708e\u300d\uff0c\u4e5f\u5305\u62ec\u300c\u982d\u76ae\u766c\u300d\u3001\u300c\u75a5\u7621\u300d\u548c\u300c\u9152\u7cdf\u9f3b\u300d\u3002 \u91cd\u5fb7 \u4eca\u5929\u5728\u7814\u8b80\u4e86\u300aZn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture\u300b(Zn2+\u5728\u9ad4\u5916\u6291\u5236\u51a0\u72c0\u75c5\u6bd2\u548c\u52d5\u8108\u75c5\u6bd2 RNA \u805a\u5408\u9175\u7d20\u6d3b\u6027\uff0c\u92c5\u96e2\u5b50\u8f09\u9ad4\u963b\u6b62\u9019\u4e9b\u75c5\u6bd2\u5728\u7d30\u80de\u57f9\u990a\u4e2d\u7684\u8907\u88fd)\u4e00\u6587\u4e4b\u5f8c\uff0c\u6709\u4e86\u4ee5\u4e0b\u7684\u5fc3\u5f97\uff1a \u3010\u5fc3\u5f97\u4e00\u3011\uff1a\u4f4e\u6fc3\u5ea6 Zn2+ \u548c PT\uff082 \u00b5M Zn2+ \u548c 2 \u00b5M PT\uff09\u7684\u7d44\u5408\u53ef\u6291\u5236\u7d30\u80de\u57f9\u990a\u4e2d\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV) \u7684\u8907\u5236\u3002 \u3010\u5fc3\u5f97\u4e8c\u3011\uff1aZn2+ \u6709\u6548\u6291\u5236\u4e86\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u75c5\u6bd2\u7684 RTC \u7684 RNA \u5408\u6210\u6d3b\u6027\u3002\u5176\u6a5f\u8f49\u53ef\u80fd\u662f\u901a\u904e\u5e72\u64fe\u75c5\u6bd2\u591a\u86cb\u767d(RTC)\u7684\u6b63\u78ba\u86cb\u767d\u6c34\u89e3\u52a0\u5de5\u3002 \u3010\u5fc3\u5f97\u4e09\u3011\uff1aZn2+ \u76f4\u63a5\u6291\u5236\u300cSARS \u51a0\u72c0\u75c5\u6bd2\u300d (SARS-CoV) \u548c\u300c\u99ac\u52d5\u8108\u708e\u75c5\u6bd2\u300d (EAV)\u5169\u7a2e\u5de2\u75c5\u6bd2\u805a\u5408\u9175\u7d20(RdRp)\u7684\u9ad4\u5916\u6d3b\u6027\u3002\u4e5f\u5c31\u662f\u8aaaZn2+ \u6703\u963b\u65b7 EAV RNA \u5408\u6210\u7684\u8d77\u59cb\u6b65\u9a5f\uff0cRdRp \u5ef6\u4f38\u53d7\u5230\u6291\u5236\uff0c\u6a21\u677f\u7d50\u5408\u6e1b\u5c11\u3002 \u3010\u5fc3\u5f97\u56db\u3011\uff1a\u901a\u904e\u7528MgEDTA\u87af\u5408Zn2+\uff0c\u53ef\u4ee5\u9006\u8f49\u4e8c\u50f9\u967d\u96e2\u5b50\u7684\u6291\u88fd\u4f5c\u7528\u3002\u8b49\u660e\u4f7f\u7528\u5206\u96e2\u7684\u8907\u5236\u8907\u5408\u7269\u548c\u7d14\u5316\u7684\u91cd\u7d44 RdRps\u53ef\u5c0d\u5de2\u72c0\u75c5\u6bd2 RdRps \u7522\u751f\u76f4\u63a5\u6291\u5236\u3002 \u7531\u6b64\uff0c\u91cd\u5fb7 \u8a8d\u70ba\u300c\u5967\u9ea5\u4e01\u92c5\u300d\u5f88\u53ef\u80fd\u53ef\u4ee5\u6210\u70ba\u201c\u92c5\u96e2\u5b50\u201d\u7684\u826f\u597d\u201c\u8f09\u9ad4\u201d\uff0c\u56e0\u6b64 \u91cd\u5fb7 \u5c07\u7e7c\u7e8c\u5728\u6b64\u4e00\u65b9\u5411\u4e2d\u6df1\u5165\u63a2\u7d22\u3002 References\u53c3\u8003\u6587\u737b Lazarczyk M, Favre M (2008) Role of Zn2+&nbsp;ions in host-virus interactions. J Virol 82: 11486\u201311494.&nbsp;&nbsp;&nbsp; \u30081. Lazarczyk M, Favre M (2008) Zn2+ \u96e2\u5b50\u5728\u5bbf\u4e3b-\u75c5\u6bd2\u76f8\u4e92\u4f5c\u7528\u4e2d\u7684\u4f5c\u7528\u3002 J Virol 82\uff1a11\u200b\u200b486\u201311494\u3002\u3009View ArticleGoogle ScholarFrederickson CJ, Koh JY, Bush AI (2005) Neurobiology of zinc in health and disease. Nat Rev Neurosci 6: 449\u2013462.&nbsp;&nbsp;&nbsp; \u30082. Frederickson CJ\u3001Koh JY\u3001Bush AI (2005) \u92c5\u5728\u5065\u5eb7\u548c\u75be\u75c5\u4e2d\u7684\u795e\u7d93\u751f\u7269\u5b78\u3002 Nat Rev Neurosci 6\uff1a449-462\u3002\u3009View ArticleGoogle ScholarAlirezaei M, Nairn AC, Glowinski J, Premont J, Marin P (1999) Zinc inhibits protein synthesis in neurons: potential rol of phosphorylation of translation initiation factor-2a. J Biol Chem 274: 32433\u201332438.&nbsp;&nbsp;&nbsp; \u30083. 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