{"id":83336,"date":"2021-08-12T13:30:22","date_gmt":"2021-08-12T13:30:22","guid":{"rendered":"http:\/\/pingtungtimes.com.tw\/?p=83336"},"modified":"2021-08-12T13:30:33","modified_gmt":"2021-08-12T13:30:33","slug":"%e9%87%8d%e5%be%b7%e3%80%80%e7%a0%94%e7%99%bc%e9%98%b2%e6%b2%bbcovid-19%e7%97%85%e6%af%92%e8%97%a5%e7%89%a9%e7%9a%84%e5%85%a5%e9%96%80%e5%8a%9f%e8%aa%b2","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=83336","title":{"rendered":"\u91cd\u5fb7\u3000\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u529f\u8ab2"},"content":{"rendered":"\n

\u3010\u674e\u91cd\u5fb7\uff0f\u5c08\u6b04\u5831\u5c0e2021\/08\/12\u3011\u3000\u91cd\u5fb7\u672c\u8eab\u7684\u5c08\u9577\u4e26\u975e\u5728\u751f\u7269\u79d1\u6280\u65b9\u9762\uff0c\u56e0\u6b64\u5f9e\u4f86\u6c92\u6709\u60f3\u904e\u81ea\u5df1\u6703\u5f9e\u4e8b\u91ab\u85e5\u65b9\u9762\u7684\u7814\u767c\u5de5\u4f5c\uff0c\u4f46\u662f\u4e0a\u500b\u6708\u795e\u4f5b\u7a81\u7136\u8aed\u793a\u91cd\u5fb7\u8aaa\u81ea\u5df1\u8ca0\u6709\u7814\u767c\u51fa\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5929\u8077\uff0c\u65bc\u662f\u91cd\u5fb7\u7a81\u7136\u88ab\u918d\u9190\u704c\u9802\u822c\u7684\u5beb\u4e86\u5e7e\u7bc7\u6709\u95dcCOVID-19\u75c5\u6bd2\u75ab\u82d7\u7684\u6587\u7ae0\uff0c\u5982\uff1a2021.07.11–\u300a\u91cd\u5fb7 \u627e\u5230\u75ab\u82d7\u9020\u6210\u8001\u8005\u731d\u6b7b\u7684\u539f\u56e0\u4e86\uff01\u300b\u30012021.07.13–\u300a\u5343\u842c\u4e0d\u8981\u8b93\u81ea\u5df1\u8b8a\u6210\u201c\u842c\u78c1\u738b\u201d\u300b\u30012021.07.15–\u300a\u91cd\u5fb7 \u7814\u767c\u65b0\u51a0\u80ba\u708e\u7684\u5c0d\u7b56\u201c\u5982\u6709\u795e\u52a9\u201d\u300b\u30012021.07.21–\u300a\u81ea\u7591\u8207\u7591\u4ed6\u662fCOVID-19\u75c5\u6bd2\u7684\u7b2c\u4e00\u500b\u75c7\u72c0\u300b\u30012021.07.24–\u300a\u91cd\u5fb7\u8981\u5728\u7b2c\u4e00\u4ecb\u9762\u963b\u64cbCOVID-19\u75c5\u6bd2\u300b\u30012021.07.29–\u300a\u201c\u9748\u7236\u201d\uff1a\u300e\u5148\u6551\u6709\u50b7\uff1b\u518d\u7d55\u75c5\u539f\u300f\u300b\u3002<\/p>\n\n\n\n

\u96d6\u7136\uff0c\u795e\u4f5b\u5df2\u7d93\u8aed\u793a\u91cd\u5fb7\u8aaa\u7d30\u80de\u4e2d\u82e5\u6709\u9ad8\u6fc3\u5ea6\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5247\u53ef\u4ee5\u9632\u6cbbCOVID-19\u75c5\u6bd2\uff0c\u4f46\u662f\u4e00\u822c\u63a1\u7528\u98df\u7528\u6216\u6ce8\u5c04\u7684\u65b9\u5f0f\u662f\u5f88\u96e3\u8b93\u7d30\u80de\u4e2d\u64c1\u6709\u9ad8\u6fc3\u5ea6\u7684\u300c\u92c5\u96e2\u5b50\u300d\u3002<\/p>\n\n\n\n

\u4f46\u662f\uff0c\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u751f\u5f17\u62c9\u57fa\u7c73\u723e\u00b7\u6fa4\u502b\u79d1\uff08Vladimir Zelenko\uff09\u535a\u58eb\uff0c\u5728\u7d10\u7d04\u6210\u529f\u6cbb\u7642\u4e86699\u540d\u60a3\u8005\u51a0\u72c0\u75c5\u6bd2\u60a3\u8005\uff0c\u6c92\u6709\u60a3\u8005\u6b7b\u4ea1\uff0c\u6c92\u6709\u60a3\u8005\u63d2\u7ba1\uff0c\u53ea\u67094\u4eba\u4f4f\u9662\u3002100%\u6210\u529f\u3002\u75c5\u4eba\u7684\u547c\u5438\u6025\u4fc3\u7665\u72c0\u5728\u6cbb\u7642\u5f8c4\u52306\u5c0f\u6642\u5167\u5c31\u6d88\u5931\u4e86\u3002<\/p>\n\n\n\n

\u4ed6\u7684\u6cd5\u5bf6\u662f\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\uff08hydroxychloroquine\uff09\u4f50\u300c\u92c5\u96e2\u5b50\u300d\u3002\u4ed6\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\uff08hydroxychloroquine\uff09\u662f\u201c\u69cd\u201d\uff0c\u800c\u300c\u92c5\u96e2\u5b50\u300d\u5247\u662f\u201c\u5b50\u5f48\u201d\uff0c\u201c\u69cd\u201d\u8207\u201c\u5b50\u5f48\u201d\u8981\u4f75\u7528\u624d\u6709\u6548\u679c\u3002\u4ed6\u628a\u9019\u4e00\u500b\u65b9\u6cd5\u544a\u8a34\u5ddd\u666e\u7e3d\u7d71\uff0c\u5ddd\u666e\u7e3d\u7d71\u4e0b\u4ee4\u8981\u8b93\u6240\u6709\u7f8e\u570b\u4eba\u90fd\u62ff\u5f97\u5230\u300c\u7fa5\u6c2f\u55b9\u300d\uff0c\u4f86\u7522\u751f\u201c\u9662\u524d\u6cbb\u7642\u201d\u7684\u6548\u679c\uff0c\u4f46\u662f\u9019\u4e00\u500b\u653f\u7b56\u537b\u88ab\u624b\u4e0b\u7d66\u6b6a\u63c9\u6389\u4e86\u3002<\/p>\n\n\n\n

\u5176\u5be6\u626e\u6f14\u9019\u500b\u201c\u69cd\u201d\u529f\u80fd\u7684\u4e0d\u53ea\u300c\u7fa5\u6c2f\u55b9\u300d\uff0c\u9023\u6700\u8fd1\u5728\u5370\u5ea6\u7522\u751f\u826f\u597d\u6cbb\u7642COVID-19\u75c5\u6bd2\u6548\u679c\u7684\u539f\u529f\u80fd\u65e8\u5728\u6e1b\u5c11\u7627\u75be\u5728\u4eba\u8207\u4eba\u4e4b\u9593\u7684\u50b3\u64ad\u7684\u300c\u4f0a\u7dad\u83cc\u300d(Ivermectin)\u4e5f\u662f\u4e00\u628a\u9001\u300c\u92c5\u96e2\u5b50\u300d\u5230\u7d30\u80de\u7684\u201c\u69cd\u201d\u3002<\/p>\n\n\n\n

\u96d6\u7136\u91cd\u5fb7\u6df1\u4fe1\u795e\u4f5b\u7684\u8aed\u793a\uff0c\u4f46\u662f\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u96d6\u7136\u662f\u4eba\u9ad4\u6240\u5fc5\u9700\uff0c\u4f46\u662f\u8eab\u9ad4\u542b\u91cf\u904e\u591a\u4e26\u7121\u76ca\u8655\uff0c\u56e0\u6b64\u6b63\u5e38\u4eba\u9ad4\u4e2d\u7d30\u80de\u7684\u6fc3\u5ea6\u4e26\u4e0d\u9ad8\u5230\u8db3\u4ee5\u6291\u5236\u75c5\u6bd2\u7684\u542b\u91cf\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u53bb\u627e\u5230\u4e00\u500b\u6709\u6548\u4e14\u5b89\u5168\u5730\u767c\u5c04\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5230\u4eba\u9ad4\u7d30\u80de\u4e2d\u7684\u201c\u69cd\u201d\uff0c\u5c31\u662f\u91cd\u5fb7\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u54c1\u7684\u653b\u95dc\u8ab2\u984c\u3002<\/p>\n\n\n\n

\u800c\u4e14\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5728\u6291\u5236\u75c5\u6bd2\u7684\u90e8\u5206\u5176\u5be6\u662f\u4e00\u7a2e\u7531\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u8207DNA\u3001RNA\u3001\u86cb\u767d\u8cea\u7d50\u5408\u7684\u7269\u8cea\uff0c\u5b83\u5c31\u662f\u6240\u8b02\u7684\u300c\u92c5\u6307\u300d\uff08Zinc finger\uff09\u3002<\/p>\n\n\n\n

\u7576\u7136\uff0c\u4e0d\u540c\u7684\u300c\u92c5\u6307\u300d\u4e5f\u5177\u6709\u4e0d\u540c\u7684\u6297\u75c5\u6bd2\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u91cd\u5fb7\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u54c1\u7684\u7b2c\u4e00\u9580\u529f\u8ab2\u5c31\u662f\u5f9e\u5c0d\u4ed8\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300d\u7684\u300c\u92c5\u6307\u9760\u75c5\u6bd2\u86cb\u767d\u300d\u7684\u7814\u7a76\u8457\u624b\u3002\u4ee5\u4e0b\u5c31\u662f\u91cd\u5fb7\u4eca\u65e9\u5728\u9ad8\u96c4\u5e02\u4e2d\u5c0f\u4f01\u696d\u5354\u6703\u7fa4\u7d44\u4e2d\u7684\u6709\u95dc\u8cbc\u6587\uff0c\u5728\u6b64\u4e00\u4f75\u63d0\u4f9b\u5404\u8b80\u53cb\u53c3\u8003\uff1a<\/p>\n\n\n\n

\u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal\nof Virology\u300b(anuary\n2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The\nShort Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus\nProtein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002<\/p>\n\n\n\n

\u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A\nvirus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  <\/p>\n\n\n\n

\u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger\nantiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP \u4f3c\u4e4e\u4e0d\u662f\u4e00\u822c\u7684\u6297\u75c5\u6bd2\u56e0\u5b50\uff1b\u5b83\u4e0d\u6703\u6291\u5236\u8907\u88fd\u4e00\u4e9b\u75c5\u6bd2\uff0c\u5982\u55ae\u7d14\u76b0\u75b9\u75c5\u6bd2 I \u578b\u548c\u9ec3\u71b1\u75c5\u75c5\u6bd2\u3002<\/p>\n\n\n\n

ZAP \u53c8\u6709\u5169\u500b\u7570\u69cb\u9ad4\uff0c\u9577\u7570\u69cb\u9ad4 (ZAPL)\u8207\u77ed\u7570\u69cb\u9ad4 (ZAPL)\u5b83\u5011\u50c5\u5728 C \u7aef\u6709\u6240\u4e0d\u540c\uff0c\u56e0\u6b64ZAP\u4fc2\u4f7f\u7528\u5169\u7a2e\u4e0d\u540c\u7684\u6a5f\u5236\u4f86\u6291\u5236 IAV \u611f\u67d3\u4ee5\u53ca\u75c5\u6bd2\u9032\u5316\u51fa\u4e0d\u540c\u7684\u62ee\u6297\u5291\u3002<\/p>\n\n\n\n

\u5927\u591a\u6578\u4ee5\u524d\u7684\u95dc\u65bc ZAP \u6297\u75c5\u6bd2\u6d3b\u6027\u53ca\u5176\u6f5b\u5728\u6a5f\u5236\u7684\u7814\u7a76\u5831\u544a\u662f\u4f7f\u7528 ZAPS\u57f7\u884c\u3002ZAPS \u76f4\u63a5\u8207\u7279\u5b9a\u75c5\u6bd2 mRNA \u7d50\u5408\u4e26\u6291\u5236\u901a\u904e\u5e72\u64fe\u7ffb\u8b6f\u8d77\u59cb\u5fa9\u5408\u7269\u7684\u7d44\u88dd\u4f86\u9776\u5411 mRNA\u3002ZAPS\u62db\u52df\u4e86\u7d30\u80de mRNA\u964d\u89e3\u6a5f\u5236\u4f86\u4fc3\u9032\u6a19\u9776 mRNA \u7684\u8870\u6e1b\u3002\u75c5\u6bd2\u662f\u5426\u5c0d ZAPS \u654f\u611f\u4f3c\u4e4e\u53d6\u6c7a\u65bc\u75c5\u6bd2 mRNA \u4e2d\u7684ZAP-\u61c9\u7b54\u5143\u4ef6\uff08ZRE\uff09\u3002<\/p>\n\n\n\n

\u5728\u9577\u7570\u69cb\u9ad4 (ZAPL) \u7684 C \u7aef\u7d50\u69cb\u57df\u88e1\u9762\uff0c\u5b58\u5728\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176(PARP) \u57df\uff0c\u5b83\u5728\u77ed\u7570\u69cb\u9ad4 (ZAPS) \u4e2d\u7f3a\u5931\u3002\u4f46\u662f\u5728 ZAP \u7684 N \u7aef\u7d50\u69cb\u57df\u4e2d\uff0c\u6709\u56db\u500b CCCH \u578b\u92c5\u6307\u57fa\u5e8f\u3002\u9577\u7570\u69cb\u9ad4 (ZAPL)\u5305\u542b\u9019\u4e9b\u92c5\u6307\u57fa\u5e8f\u7684 254 \u500b\u6c28\u57fa\u9178\u7684 N \u7aef\u7d50\u69cb\u57df\u8207 zeocin\n\u6297\u6027\u57fa\u56e0\u7522\u7269\u878d\u5408\uff0c\u986f\u793a\u51fa\u8207\u6297\u75c5\u6bd2\u6d3b\u6027\u76f8\u7576\u7684\u5168\u9577\u86cb\u767d\u81f3\u5c11\u5c0d\u67d0\u4e9b\u75c5\u6bd2\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u56e0\u6b64\u4e5f\u662f\u8a72\u7814\u7a76\u8ab2\u984c\u7684\u91cd\u9ede\u3002<\/p>\n\n\n\n

\u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u7d50\u679c\u3011\uff1a<\/p>\n\n\n\n

\u25cf ZAPS \u6291\u5236 IAV \u86cb\u767d PA\u3001PB2 \u548c NA \u7684\u8868\u9054\u3002<\/p>\n\n\n\n

\u25cf ZAPS \u964d\u4f4e PB2 mRNA \u6c34\u5e73\u4e26\u6291\u5236\u5176\u7ffb\u8b6f\u3002<\/p>\n\n\n\n

\u25cf ZAP \u50c5\u5728\u65e9\u671f\u6291\u5236 IAV \u8907\u88fd\u3002<\/p>\n\n\n\n

\u25cf NS1\u548cNP\u7684\u904e\u8868\u9054\u6291\u5236ZAPS\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002<\/p>\n\n\n\n

\u25cf NS1 \u901a\u904e\u964d\u4f4e\u5176 RNA \u7d50\u5408\u6d3b\u6027\u4f86\u62ee\u6297 ZAPS\u3002<\/p>\n\n\n\n

\u25cf \u651c\u5e36 NS1-m7 \u7684\u91cd\u7d44 IAV \u5728 ZAPS \u7f3a\u9677\u7d30\u80de\u4e2d\u5fa9\u88fd\u5f97\u66f4\u597d\u3002<\/p>\n\n\n\n

\u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u8a0e\u8ad6\u3011\uff1a<\/p>\n\n\n\n

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\u7576\u7136\uff0c\u4e0d\u540c\u7684\u300c\u92c5\u6307\u300d\u4e5f\u5177\u6709\u4e0d\u540c\u7684\u6297\u75c5\u6bd2\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u91cd\u5fb7\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u54c1\u7684\u7b2c\u4e00\u9580\u529f\u8ab2\u5c31\u662f\u5f9e\u5c0d\u4ed8\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300d\u7684\u300c\u92c5\u6307\u9760\u75c5\u6bd2\u86cb\u767d\u300d\u7684\u7814\u7a76\u8457\u624b\u3002\u4ee5\u4e0b\u5c31\u662f\u91cd\u5fb7\u4eca\u65e9\u5728\u9ad8\u96c4\u5e02\u4e2d\u5c0f\u4f01\u696d\u5354\u6703\u7fa4\u7d44\u4e2d\u7684\u6709\u95dc\u8cbc\u6587\uff0c\u5728\u6b64\u4e00\u4f75\u63d0\u4f9b\u5404\u8b80\u53cb\u53c3\u8003\uff1a \u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal of Virology\u300b(anuary 2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002 \u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A virus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  \u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger antiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP \u4f3c\u4e4e\u4e0d\u662f\u4e00\u822c\u7684\u6297\u75c5\u6bd2\u56e0\u5b50\uff1b\u5b83\u4e0d\u6703\u6291\u5236\u8907\u88fd\u4e00\u4e9b\u75c5\u6bd2\uff0c\u5982\u55ae\u7d14\u76b0\u75b9\u75c5\u6bd2 I \u578b\u548c\u9ec3\u71b1\u75c5\u75c5\u6bd2\u3002 ZAP \u53c8\u6709\u5169\u500b\u7570\u69cb\u9ad4\uff0c\u9577\u7570\u69cb\u9ad4 (ZAPL)\u8207\u77ed\u7570\u69cb\u9ad4 (ZAPL)\u5b83\u5011\u50c5\u5728 C \u7aef\u6709\u6240\u4e0d\u540c\uff0c\u56e0\u6b64ZAP\u4fc2\u4f7f\u7528\u5169\u7a2e\u4e0d\u540c\u7684\u6a5f\u5236\u4f86\u6291\u5236 IAV \u611f\u67d3\u4ee5\u53ca\u75c5\u6bd2\u9032\u5316\u51fa\u4e0d\u540c\u7684\u62ee\u6297\u5291\u3002 \u5927\u591a\u6578\u4ee5\u524d\u7684\u95dc\u65bc ZAP \u6297\u75c5\u6bd2\u6d3b\u6027\u53ca\u5176\u6f5b\u5728\u6a5f\u5236\u7684\u7814\u7a76\u5831\u544a\u662f\u4f7f\u7528 ZAPS\u57f7\u884c\u3002ZAPS \u76f4\u63a5\u8207\u7279\u5b9a\u75c5\u6bd2 mRNA \u7d50\u5408\u4e26\u6291\u5236\u901a\u904e\u5e72\u64fe\u7ffb\u8b6f\u8d77\u59cb\u5fa9\u5408\u7269\u7684\u7d44\u88dd\u4f86\u9776\u5411 mRNA\u3002ZAPS\u62db\u52df\u4e86\u7d30\u80de mRNA\u964d\u89e3\u6a5f\u5236\u4f86\u4fc3\u9032\u6a19\u9776 mRNA \u7684\u8870\u6e1b\u3002\u75c5\u6bd2\u662f\u5426\u5c0d ZAPS \u654f\u611f\u4f3c\u4e4e\u53d6\u6c7a\u65bc\u75c5\u6bd2 mRNA \u4e2d\u7684ZAP-\u61c9\u7b54\u5143\u4ef6\uff08ZRE\uff09\u3002 \u5728\u9577\u7570\u69cb\u9ad4 (ZAPL) \u7684 C \u7aef\u7d50\u69cb\u57df\u88e1\u9762\uff0c\u5b58\u5728\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176(PARP) \u57df\uff0c\u5b83\u5728\u77ed\u7570\u69cb\u9ad4 (ZAPS) \u4e2d\u7f3a\u5931\u3002\u4f46\u662f\u5728 ZAP \u7684 N \u7aef\u7d50\u69cb\u57df\u4e2d\uff0c\u6709\u56db\u500b CCCH \u578b\u92c5\u6307\u57fa\u5e8f\u3002\u9577\u7570\u69cb\u9ad4 (ZAPL)\u5305\u542b\u9019\u4e9b\u92c5\u6307\u57fa\u5e8f\u7684 254 \u500b\u6c28\u57fa\u9178\u7684 N \u7aef\u7d50\u69cb\u57df\u8207 zeocin \u6297\u6027\u57fa\u56e0\u7522\u7269\u878d\u5408\uff0c\u986f\u793a\u51fa\u8207\u6297\u75c5\u6bd2\u6d3b\u6027\u76f8\u7576\u7684\u5168\u9577\u86cb\u767d\u81f3\u5c11\u5c0d\u67d0\u4e9b\u75c5\u6bd2\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u56e0\u6b64\u4e5f\u662f\u8a72\u7814\u7a76\u8ab2\u984c\u7684\u91cd\u9ede\u3002 \u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u7d50\u679c\u3011\uff1a \u25cf ZAPS \u6291\u5236 IAV \u86cb\u767d PA\u3001PB2 \u548c NA \u7684\u8868\u9054\u3002 \u25cf ZAPS \u964d\u4f4e PB2 mRNA \u6c34\u5e73\u4e26\u6291\u5236\u5176\u7ffb\u8b6f\u3002 \u25cf ZAP \u50c5\u5728\u65e9\u671f\u6291\u5236 IAV \u8907\u88fd\u3002 \u25cf NS1\u548cNP\u7684\u904e\u8868\u9054\u6291\u5236ZAPS\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 \u25cf NS1 \u901a\u904e\u964d\u4f4e\u5176 RNA \u7d50\u5408\u6d3b\u6027\u4f86\u62ee\u6297 ZAPS\u3002 \u25cf \u651c\u5e36 NS1-m7 \u7684\u91cd\u7d44 IAV \u5728 ZAPS \u7f3a\u9677\u7d30\u80de\u4e2d\u5fa9\u88fd\u5f97\u66f4\u597d\u3002 \u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u8a0e\u8ad6\u3011\uff1a \u25cf IAV \u7684\u611f\u67d3\u8a98\u5c0e\u4e86 IFN \u4ecb\u5c0e\u7684\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u901a\u904e\u4fc3\u9032 PB2 \u548c PA \u7684\u86cb\u767d\u9176\u9ad4\u964d\u89e3\u4f86\u6291\u5236 IAV \u7684\u8907\u5236\u3002ZAPS \u8f49\u9304\u5f8c\u6291\u5236 IAV \u86cb\u767d\u8868\u9054\u3002 \u25cf \u70ba\u4e86\u5efa\u7acb\u6709\u6548\u7684\u611f\u67d3\uff0c\u75c5\u6bd2\u9700\u8981\u767c\u5c55\u6a5f\u5236\u4f86\u62b5\u6d88\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab PB1 \u62ee\u6297\u3002ZAPS \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab NS1 \u62ee\u6297\u3002 \u25cf \u5be6\u9a57\u7d50\u679c\u986f\u793aNS1 \u901a\u904e\u6e1b\u5c11\u5176\u8207\u6a19\u9776 RNA \u7684\u7d50\u5408\u4f86\u62ee\u6297 ZAP\u3002\u7d50\u679c\u8868\u660e NS1 \u4e0d\u6703\u901a\u904e\u8207 ZAPS \u7af6\u722d\u7d50\u5408\u6a19\u9776 RNA \u4f86\u62ee\u6297 ZAPS\u3002NS1 \u5982\u4f55\u964d\u4f4e ZAP \u7684 RNA \u7d50\u5408\u6d3b\u6027\uff0c\u5c1a\u4e0d\u6e05\u695a\u3002 \u25cf \u5be6\u9a57\u986f\u793a\u9020\u6210\u5931\u53bb ZAPS-\u62ee\u6297\u6d3b\u6027\u7684\u662f NS1 \u7a81\u8b8a\u9ad4 NS1-m7 \u548c NS1-m9\u3002\u56e0\u6b64\u662fNS1 \u5982\u4f55\u964d\u4f4eZAPS-\u62ee\u6297\u6d3b\u6027\u7684\u95dc\u9375\u56e0\u7d20\u3002\u5176\u6a5f\u8f49\u539f\u56e0\u5c1a\u4e0d\u6e05\u695a\u3002 \u25cf \u7d50\u8ad6\u4e00\uff1aZAPS \u5728\u611f\u67d3\u7684\u65e9\u671f\u968e\u6bb5\u78ba\u5be6\u80fd\u6291\u5236 IAV \u8907\u88fd\uff0c\u81f3\u5c11\u90e8\u5206\u662f\u901a\u904e\u8f49\u9304\u5f8c\u6291\u5236 PA\u3001PB2 \u548c NA \u7684\u8868\u9054\u3002 \u25cf \u7d50\u8ad6\u4e8c\uff1a\u4f46\u662fZAP \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab\u75c5\u6bd2\u7de8\u78bc\u7684 NS1 \u62ee\u6297\uff0c\u5c0d NS1 \u62ee\u6297 ZAPS 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content=\"\u3010\u674e\u91cd\u5fb7\uff0f\u5c08\u6b04\u5831\u5c0e2021\/08\/12\u3011\u3000\u91cd\u5fb7\u672c\u8eab\u7684\u5c08\u9577\u4e26\u975e\u5728\u751f\u7269\u79d1\u6280\u65b9\u9762\uff0c\u56e0\u6b64\u5f9e\u4f86\u6c92\u6709\u60f3\u904e\u81ea\u5df1\u6703\u5f9e\u4e8b\u91ab\u85e5\u65b9\u9762\u7684\u7814\u767c\u5de5\u4f5c\uff0c\u4f46\u662f\u4e0a\u500b\u6708\u795e\u4f5b\u7a81\u7136\u8aed\u793a\u91cd\u5fb7\u8aaa\u81ea\u5df1\u8ca0\u6709\u7814\u767c\u51fa\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5929\u8077\uff0c\u65bc\u662f\u91cd\u5fb7\u7a81\u7136\u88ab\u918d\u9190\u704c\u9802\u822c\u7684\u5beb\u4e86\u5e7e\u7bc7\u6709\u95dcCOVID-19\u75c5\u6bd2\u75ab\u82d7\u7684\u6587\u7ae0\uff0c\u5982\uff1a2021.07.11--\u300a\u91cd\u5fb7 \u627e\u5230\u75ab\u82d7\u9020\u6210\u8001\u8005\u731d\u6b7b\u7684\u539f\u56e0\u4e86\uff01\u300b\u30012021.07.13--\u300a\u5343\u842c\u4e0d\u8981\u8b93\u81ea\u5df1\u8b8a\u6210\u201c\u842c\u78c1\u738b\u201d\u300b\u30012021.07.15--\u300a\u91cd\u5fb7 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\u800c\u4e14\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5728\u6291\u5236\u75c5\u6bd2\u7684\u90e8\u5206\u5176\u5be6\u662f\u4e00\u7a2e\u7531\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u8207DNA\u3001RNA\u3001\u86cb\u767d\u8cea\u7d50\u5408\u7684\u7269\u8cea\uff0c\u5b83\u5c31\u662f\u6240\u8b02\u7684\u300c\u92c5\u6307\u300d\uff08Zinc finger\uff09\u3002 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\u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal of Virology\u300b(anuary 2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002 \u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A virus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  \u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger antiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP 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\u7f3a\u9677\u7d30\u80de\u4e2d\u5fa9\u88fd\u5f97\u66f4\u597d\u3002 \u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u8a0e\u8ad6\u3011\uff1a \u25cf IAV \u7684\u611f\u67d3\u8a98\u5c0e\u4e86 IFN \u4ecb\u5c0e\u7684\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u901a\u904e\u4fc3\u9032 PB2 \u548c PA \u7684\u86cb\u767d\u9176\u9ad4\u964d\u89e3\u4f86\u6291\u5236 IAV \u7684\u8907\u5236\u3002ZAPS \u8f49\u9304\u5f8c\u6291\u5236 IAV \u86cb\u767d\u8868\u9054\u3002 \u25cf \u70ba\u4e86\u5efa\u7acb\u6709\u6548\u7684\u611f\u67d3\uff0c\u75c5\u6bd2\u9700\u8981\u767c\u5c55\u6a5f\u5236\u4f86\u62b5\u6d88\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab PB1 \u62ee\u6297\u3002ZAPS \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab NS1 \u62ee\u6297\u3002 \u25cf \u5be6\u9a57\u7d50\u679c\u986f\u793aNS1 \u901a\u904e\u6e1b\u5c11\u5176\u8207\u6a19\u9776 RNA \u7684\u7d50\u5408\u4f86\u62ee\u6297 ZAP\u3002\u7d50\u679c\u8868\u660e NS1 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\u96d6\u7136\uff0c\u795e\u4f5b\u5df2\u7d93\u8aed\u793a\u91cd\u5fb7\u8aaa\u7d30\u80de\u4e2d\u82e5\u6709\u9ad8\u6fc3\u5ea6\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5247\u53ef\u4ee5\u9632\u6cbbCOVID-19\u75c5\u6bd2\uff0c\u4f46\u662f\u4e00\u822c\u63a1\u7528\u98df\u7528\u6216\u6ce8\u5c04\u7684\u65b9\u5f0f\u662f\u5f88\u96e3\u8b93\u7d30\u80de\u4e2d\u64c1\u6709\u9ad8\u6fc3\u5ea6\u7684\u300c\u92c5\u96e2\u5b50\u300d\u3002 \u4f46\u662f\uff0c\u7f8e\u570b\u7684\u4e00\u4f4d\u793e\u5340\u91ab\u751f\u5f17\u62c9\u57fa\u7c73\u723e\u00b7\u6fa4\u502b\u79d1\uff08Vladimir Zelenko\uff09\u535a\u58eb\uff0c\u5728\u7d10\u7d04\u6210\u529f\u6cbb\u7642\u4e86699\u540d\u60a3\u8005\u51a0\u72c0\u75c5\u6bd2\u60a3\u8005\uff0c\u6c92\u6709\u60a3\u8005\u6b7b\u4ea1\uff0c\u6c92\u6709\u60a3\u8005\u63d2\u7ba1\uff0c\u53ea\u67094\u4eba\u4f4f\u9662\u3002100%\u6210\u529f\u3002\u75c5\u4eba\u7684\u547c\u5438\u6025\u4fc3\u7665\u72c0\u5728\u6cbb\u7642\u5f8c4\u52306\u5c0f\u6642\u5167\u5c31\u6d88\u5931\u4e86\u3002 \u4ed6\u7684\u6cd5\u5bf6\u662f\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\uff08hydroxychloroquine\uff09\u4f50\u300c\u92c5\u96e2\u5b50\u300d\u3002\u4ed6\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\uff08hydroxychloroquine\uff09\u662f\u201c\u69cd\u201d\uff0c\u800c\u300c\u92c5\u96e2\u5b50\u300d\u5247\u662f\u201c\u5b50\u5f48\u201d\uff0c\u201c\u69cd\u201d\u8207\u201c\u5b50\u5f48\u201d\u8981\u4f75\u7528\u624d\u6709\u6548\u679c\u3002\u4ed6\u628a\u9019\u4e00\u500b\u65b9\u6cd5\u544a\u8a34\u5ddd\u666e\u7e3d\u7d71\uff0c\u5ddd\u666e\u7e3d\u7d71\u4e0b\u4ee4\u8981\u8b93\u6240\u6709\u7f8e\u570b\u4eba\u90fd\u62ff\u5f97\u5230\u300c\u7fa5\u6c2f\u55b9\u300d\uff0c\u4f86\u7522\u751f\u201c\u9662\u524d\u6cbb\u7642\u201d\u7684\u6548\u679c\uff0c\u4f46\u662f\u9019\u4e00\u500b\u653f\u7b56\u537b\u88ab\u624b\u4e0b\u7d66\u6b6a\u63c9\u6389\u4e86\u3002 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\u800c\u4e14\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5728\u6291\u5236\u75c5\u6bd2\u7684\u90e8\u5206\u5176\u5be6\u662f\u4e00\u7a2e\u7531\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u8207DNA\u3001RNA\u3001\u86cb\u767d\u8cea\u7d50\u5408\u7684\u7269\u8cea\uff0c\u5b83\u5c31\u662f\u6240\u8b02\u7684\u300c\u92c5\u6307\u300d\uff08Zinc finger\uff09\u3002 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\u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal of Virology\u300b(anuary 2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002 \u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A virus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  \u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger antiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP 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mRNA\u3002ZAPS\u62db\u52df\u4e86\u7d30\u80de mRNA\u964d\u89e3\u6a5f\u5236\u4f86\u4fc3\u9032\u6a19\u9776 mRNA \u7684\u8870\u6e1b\u3002\u75c5\u6bd2\u662f\u5426\u5c0d ZAPS \u654f\u611f\u4f3c\u4e4e\u53d6\u6c7a\u65bc\u75c5\u6bd2 mRNA \u4e2d\u7684ZAP-\u61c9\u7b54\u5143\u4ef6\uff08ZRE\uff09\u3002 \u5728\u9577\u7570\u69cb\u9ad4 (ZAPL) \u7684 C \u7aef\u7d50\u69cb\u57df\u88e1\u9762\uff0c\u5b58\u5728\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176(PARP) \u57df\uff0c\u5b83\u5728\u77ed\u7570\u69cb\u9ad4 (ZAPS) \u4e2d\u7f3a\u5931\u3002\u4f46\u662f\u5728 ZAP \u7684 N \u7aef\u7d50\u69cb\u57df\u4e2d\uff0c\u6709\u56db\u500b CCCH \u578b\u92c5\u6307\u57fa\u5e8f\u3002\u9577\u7570\u69cb\u9ad4 (ZAPL)\u5305\u542b\u9019\u4e9b\u92c5\u6307\u57fa\u5e8f\u7684 254 \u500b\u6c28\u57fa\u9178\u7684 N \u7aef\u7d50\u69cb\u57df\u8207 zeocin 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\u7f3a\u9677\u7d30\u80de\u4e2d\u5fa9\u88fd\u5f97\u66f4\u597d\u3002 \u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u8a0e\u8ad6\u3011\uff1a \u25cf IAV \u7684\u611f\u67d3\u8a98\u5c0e\u4e86 IFN \u4ecb\u5c0e\u7684\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u901a\u904e\u4fc3\u9032 PB2 \u548c PA \u7684\u86cb\u767d\u9176\u9ad4\u964d\u89e3\u4f86\u6291\u5236 IAV \u7684\u8907\u5236\u3002ZAPS \u8f49\u9304\u5f8c\u6291\u5236 IAV \u86cb\u767d\u8868\u9054\u3002 \u25cf \u70ba\u4e86\u5efa\u7acb\u6709\u6548\u7684\u611f\u67d3\uff0c\u75c5\u6bd2\u9700\u8981\u767c\u5c55\u6a5f\u5236\u4f86\u62b5\u6d88\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab PB1 \u62ee\u6297\u3002ZAPS \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab NS1 \u62ee\u6297\u3002 \u25cf \u5be6\u9a57\u7d50\u679c\u986f\u793aNS1 \u901a\u904e\u6e1b\u5c11\u5176\u8207\u6a19\u9776 RNA \u7684\u7d50\u5408\u4f86\u62ee\u6297 ZAP\u3002\u7d50\u679c\u8868\u660e NS1 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\u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal of Virology\u300b(anuary 2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002 \u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A virus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  \u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger antiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP 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\u4ed6\u7684\u6cd5\u5bf6\u662f\u4f7f\u7528\u300c\u7fa5\u6c2f\u55b9\u300d\uff08hydroxychloroquine\uff09\u4f50\u300c\u92c5\u96e2\u5b50\u300d\u3002\u4ed6\u8aaa\u300c\u7fa5\u6c2f\u55b9\u300d\uff08hydroxychloroquine\uff09\u662f\u201c\u69cd\u201d\uff0c\u800c\u300c\u92c5\u96e2\u5b50\u300d\u5247\u662f\u201c\u5b50\u5f48\u201d\uff0c\u201c\u69cd\u201d\u8207\u201c\u5b50\u5f48\u201d\u8981\u4f75\u7528\u624d\u6709\u6548\u679c\u3002\u4ed6\u628a\u9019\u4e00\u500b\u65b9\u6cd5\u544a\u8a34\u5ddd\u666e\u7e3d\u7d71\uff0c\u5ddd\u666e\u7e3d\u7d71\u4e0b\u4ee4\u8981\u8b93\u6240\u6709\u7f8e\u570b\u4eba\u90fd\u62ff\u5f97\u5230\u300c\u7fa5\u6c2f\u55b9\u300d\uff0c\u4f86\u7522\u751f\u201c\u9662\u524d\u6cbb\u7642\u201d\u7684\u6548\u679c\uff0c\u4f46\u662f\u9019\u4e00\u500b\u653f\u7b56\u537b\u88ab\u624b\u4e0b\u7d66\u6b6a\u63c9\u6389\u4e86\u3002 \u5176\u5be6\u626e\u6f14\u9019\u500b\u201c\u69cd\u201d\u529f\u80fd\u7684\u4e0d\u53ea\u300c\u7fa5\u6c2f\u55b9\u300d\uff0c\u9023\u6700\u8fd1\u5728\u5370\u5ea6\u7522\u751f\u826f\u597d\u6cbb\u7642COVID-19\u75c5\u6bd2\u6548\u679c\u7684\u539f\u529f\u80fd\u65e8\u5728\u6e1b\u5c11\u7627\u75be\u5728\u4eba\u8207\u4eba\u4e4b\u9593\u7684\u50b3\u64ad\u7684\u300c\u4f0a\u7dad\u83cc\u300d(Ivermectin)\u4e5f\u662f\u4e00\u628a\u9001\u300c\u92c5\u96e2\u5b50\u300d\u5230\u7d30\u80de\u7684\u201c\u69cd\u201d\u3002 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\u800c\u4e14\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5728\u6291\u5236\u75c5\u6bd2\u7684\u90e8\u5206\u5176\u5be6\u662f\u4e00\u7a2e\u7531\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u8207DNA\u3001RNA\u3001\u86cb\u767d\u8cea\u7d50\u5408\u7684\u7269\u8cea\uff0c\u5b83\u5c31\u662f\u6240\u8b02\u7684\u300c\u92c5\u6307\u300d\uff08Zinc finger\uff09\u3002 \u7576\u7136\uff0c\u4e0d\u540c\u7684\u300c\u92c5\u6307\u300d\u4e5f\u5177\u6709\u4e0d\u540c\u7684\u6297\u75c5\u6bd2\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u91cd\u5fb7\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u54c1\u7684\u7b2c\u4e00\u9580\u529f\u8ab2\u5c31\u662f\u5f9e\u5c0d\u4ed8\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300d\u7684\u300c\u92c5\u6307\u9760\u75c5\u6bd2\u86cb\u767d\u300d\u7684\u7814\u7a76\u8457\u624b\u3002\u4ee5\u4e0b\u5c31\u662f\u91cd\u5fb7\u4eca\u65e9\u5728\u9ad8\u96c4\u5e02\u4e2d\u5c0f\u4f01\u696d\u5354\u6703\u7fa4\u7d44\u4e2d\u7684\u6709\u95dc\u8cbc\u6587\uff0c\u5728\u6b64\u4e00\u4f75\u63d0\u4f9b\u5404\u8b80\u53cb\u53c3\u8003\uff1a \u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal of Virology\u300b(anuary 2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002 \u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A virus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  \u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger antiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP 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mRNA\u3002ZAPS\u62db\u52df\u4e86\u7d30\u80de mRNA\u964d\u89e3\u6a5f\u5236\u4f86\u4fc3\u9032\u6a19\u9776 mRNA \u7684\u8870\u6e1b\u3002\u75c5\u6bd2\u662f\u5426\u5c0d ZAPS \u654f\u611f\u4f3c\u4e4e\u53d6\u6c7a\u65bc\u75c5\u6bd2 mRNA \u4e2d\u7684ZAP-\u61c9\u7b54\u5143\u4ef6\uff08ZRE\uff09\u3002 \u5728\u9577\u7570\u69cb\u9ad4 (ZAPL) \u7684 C \u7aef\u7d50\u69cb\u57df\u88e1\u9762\uff0c\u5b58\u5728\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176(PARP) \u57df\uff0c\u5b83\u5728\u77ed\u7570\u69cb\u9ad4 (ZAPS) \u4e2d\u7f3a\u5931\u3002\u4f46\u662f\u5728 ZAP \u7684 N \u7aef\u7d50\u69cb\u57df\u4e2d\uff0c\u6709\u56db\u500b CCCH \u578b\u92c5\u6307\u57fa\u5e8f\u3002\u9577\u7570\u69cb\u9ad4 (ZAPL)\u5305\u542b\u9019\u4e9b\u92c5\u6307\u57fa\u5e8f\u7684 254 \u500b\u6c28\u57fa\u9178\u7684 N \u7aef\u7d50\u69cb\u57df\u8207 zeocin 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\u96d6\u7136\u91cd\u5fb7\u6df1\u4fe1\u795e\u4f5b\u7684\u8aed\u793a\uff0c\u4f46\u662f\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u96d6\u7136\u662f\u4eba\u9ad4\u6240\u5fc5\u9700\uff0c\u4f46\u662f\u8eab\u9ad4\u542b\u91cf\u904e\u591a\u4e26\u7121\u76ca\u8655\uff0c\u56e0\u6b64\u6b63\u5e38\u4eba\u9ad4\u4e2d\u7d30\u80de\u7684\u6fc3\u5ea6\u4e26\u4e0d\u9ad8\u5230\u8db3\u4ee5\u6291\u5236\u75c5\u6bd2\u7684\u542b\u91cf\u3002\u56e0\u6b64\uff0c\u5982\u4f55\u53bb\u627e\u5230\u4e00\u500b\u6709\u6548\u4e14\u5b89\u5168\u5730\u767c\u5c04\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5230\u4eba\u9ad4\u7d30\u80de\u4e2d\u7684\u201c\u69cd\u201d\uff0c\u5c31\u662f\u91cd\u5fb7\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u54c1\u7684\u653b\u95dc\u8ab2\u984c\u3002 \u800c\u4e14\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u5728\u6291\u5236\u75c5\u6bd2\u7684\u90e8\u5206\u5176\u5be6\u662f\u4e00\u7a2e\u7531\u300c\u92c5\u96e2\u5b50\u300d\uff08Zn2+\uff09\u8207DNA\u3001RNA\u3001\u86cb\u767d\u8cea\u7d50\u5408\u7684\u7269\u8cea\uff0c\u5b83\u5c31\u662f\u6240\u8b02\u7684\u300c\u92c5\u6307\u300d\uff08Zinc finger\uff09\u3002 \u7576\u7136\uff0c\u4e0d\u540c\u7684\u300c\u92c5\u6307\u300d\u4e5f\u5177\u6709\u4e0d\u540c\u7684\u6297\u75c5\u6bd2\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u91cd\u5fb7\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u54c1\u7684\u7b2c\u4e00\u9580\u529f\u8ab2\u5c31\u662f\u5f9e\u5c0d\u4ed8\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300d\u7684\u300c\u92c5\u6307\u9760\u75c5\u6bd2\u86cb\u767d\u300d\u7684\u7814\u7a76\u8457\u624b\u3002\u4ee5\u4e0b\u5c31\u662f\u91cd\u5fb7\u4eca\u65e9\u5728\u9ad8\u96c4\u5e02\u4e2d\u5c0f\u4f01\u696d\u5354\u6703\u7fa4\u7d44\u4e2d\u7684\u6709\u95dc\u8cbc\u6587\uff0c\u5728\u6b64\u4e00\u4f75\u63d0\u4f9b\u5404\u8b80\u53cb\u53c3\u8003\uff1a \u6628\u5929\uff0c\u91cd\u5fb7\u8acb\u5927\u5bb6\u4e00\u8d77\u53c3\u8207\u7814\u8b80\u4e2d\u570b\u79d1\u5b78\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u611f\u67d3\u8207\u514d\u75ab\u5b78\u91cd\u9ede\u5be6\u9a57\u5ba4\u4e09\u4f4d\u5c08\u5bb6\u5728\u7f8e\u570b\u7684\u5fae\u751f\u7269\u7814\u7a76\u4e2d\u5fc3\u6240\u4e3b\u7de8\u7684\u300aJournal of Virology\u300b(anuary 2017 Volume 91 Issue 2 e01909-16)\u767c\u8868\u7684\uff1a\u3008The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1\u3009\u4e00\u6587\u4e2d\u3002 \u96d6\u7136\u8a72\u6587\u7ae0\u4e26\u975e\u662f\u91dd\u5c0d\u9632\u6cbbCOVID-19\u75c5\u6bd2\u800c\u505a\u7684\u5be6\u9a57\uff0c\u800c\u662f\u91dd\u5c0d\u300c\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u300dIAV (influenza A virus)\u7684\u5be6\u9a57\u5831\u544a\uff0c\u4f46\u662f\u7531\u65bc\u7532\u578b\u6d41\u611f\u75c5\u6bd2\u8207COVID-19\u75c5\u6bd2\u6709\u985e\u4f3c\u7684\u8868\u73fe\uff0c\u56e0\u6b64\u4e5f\u662f\u91cd\u5fb7\u5c0d\u65bc\u7814\u767c\u9632\u6cbbCOVID-19\u75c5\u6bd2\u85e5\u7269\u7684\u5165\u9580\u53c3\u8003\u8cc7\u6599\u3002  \u9019\u500b\u7814\u7a76\u8ab2\u984c\u7684\u4e3b\u89d2\u662f\u300c\u92c5\u6307\u6297\u75c5\u6bd2\u86cb\u767d\u300d(Zinc finger antiviral protein\uff1bZAP) \u5b83\u662f\u4e00\u7a2e I \u578b\u5e72\u64fe\u7d20 (IFN) \u8a98\u5c0e\u5bbf\u4e3b\u56e0\u5b50(1-3) \uff0c\u5b83\u80fd\u6291\u5236\u67d0\u4e9b\u75c5\u6bd2\u7684\u8907\u5236\uff0c\u5305\u62ec Sindbis \u75c5\u6bd2 (SINV)\u548c\u7f85\u65af\u6cb3\u75c5\u6bd2\u3001\u57c3\u535a\u62c9\u75c5\u6bd2\u548c\u99ac\u723e\u5821\u75c5\u6bd2\u3001\u9f20\u767d\u8840\u75c5\u75c5\u6bd2 (MLV)\u3001\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2 1 \u578b (HIV-1)\u548c\u4e59\u578b\u809d\u708e\u75c5\u6bd2 (HBV)\u3002\u4f46\u662fZAP \u4f3c\u4e4e\u4e0d\u662f\u4e00\u822c\u7684\u6297\u75c5\u6bd2\u56e0\u5b50\uff1b\u5b83\u4e0d\u6703\u6291\u5236\u8907\u88fd\u4e00\u4e9b\u75c5\u6bd2\uff0c\u5982\u55ae\u7d14\u76b0\u75b9\u75c5\u6bd2 I \u578b\u548c\u9ec3\u71b1\u75c5\u75c5\u6bd2\u3002 ZAP \u53c8\u6709\u5169\u500b\u7570\u69cb\u9ad4\uff0c\u9577\u7570\u69cb\u9ad4 (ZAPL)\u8207\u77ed\u7570\u69cb\u9ad4 (ZAPL)\u5b83\u5011\u50c5\u5728 C \u7aef\u6709\u6240\u4e0d\u540c\uff0c\u56e0\u6b64ZAP\u4fc2\u4f7f\u7528\u5169\u7a2e\u4e0d\u540c\u7684\u6a5f\u5236\u4f86\u6291\u5236 IAV \u611f\u67d3\u4ee5\u53ca\u75c5\u6bd2\u9032\u5316\u51fa\u4e0d\u540c\u7684\u62ee\u6297\u5291\u3002 \u5927\u591a\u6578\u4ee5\u524d\u7684\u95dc\u65bc ZAP \u6297\u75c5\u6bd2\u6d3b\u6027\u53ca\u5176\u6f5b\u5728\u6a5f\u5236\u7684\u7814\u7a76\u5831\u544a\u662f\u4f7f\u7528 ZAPS\u57f7\u884c\u3002ZAPS \u76f4\u63a5\u8207\u7279\u5b9a\u75c5\u6bd2 mRNA \u7d50\u5408\u4e26\u6291\u5236\u901a\u904e\u5e72\u64fe\u7ffb\u8b6f\u8d77\u59cb\u5fa9\u5408\u7269\u7684\u7d44\u88dd\u4f86\u9776\u5411 mRNA\u3002ZAPS\u62db\u52df\u4e86\u7d30\u80de mRNA\u964d\u89e3\u6a5f\u5236\u4f86\u4fc3\u9032\u6a19\u9776 mRNA \u7684\u8870\u6e1b\u3002\u75c5\u6bd2\u662f\u5426\u5c0d ZAPS \u654f\u611f\u4f3c\u4e4e\u53d6\u6c7a\u65bc\u75c5\u6bd2 mRNA \u4e2d\u7684ZAP-\u61c9\u7b54\u5143\u4ef6\uff08ZRE\uff09\u3002 \u5728\u9577\u7570\u69cb\u9ad4 (ZAPL) \u7684 C \u7aef\u7d50\u69cb\u57df\u88e1\u9762\uff0c\u5b58\u5728\u805a\uff08ADP-\u6838\u7cd6\uff09\u805a\u5408\u9176(PARP) \u57df\uff0c\u5b83\u5728\u77ed\u7570\u69cb\u9ad4 (ZAPS) \u4e2d\u7f3a\u5931\u3002\u4f46\u662f\u5728 ZAP \u7684 N \u7aef\u7d50\u69cb\u57df\u4e2d\uff0c\u6709\u56db\u500b CCCH \u578b\u92c5\u6307\u57fa\u5e8f\u3002\u9577\u7570\u69cb\u9ad4 (ZAPL)\u5305\u542b\u9019\u4e9b\u92c5\u6307\u57fa\u5e8f\u7684 254 \u500b\u6c28\u57fa\u9178\u7684 N \u7aef\u7d50\u69cb\u57df\u8207 zeocin \u6297\u6027\u57fa\u56e0\u7522\u7269\u878d\u5408\uff0c\u986f\u793a\u51fa\u8207\u6297\u75c5\u6bd2\u6d3b\u6027\u76f8\u7576\u7684\u5168\u9577\u86cb\u767d\u81f3\u5c11\u5c0d\u67d0\u4e9b\u75c5\u6bd2\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u56e0\u6b64\u4e5f\u662f\u8a72\u7814\u7a76\u8ab2\u984c\u7684\u91cd\u9ede\u3002 \u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u7d50\u679c\u3011\uff1a \u25cf ZAPS \u6291\u5236 IAV \u86cb\u767d PA\u3001PB2 \u548c NA \u7684\u8868\u9054\u3002 \u25cf ZAPS \u964d\u4f4e PB2 mRNA \u6c34\u5e73\u4e26\u6291\u5236\u5176\u7ffb\u8b6f\u3002 \u25cf ZAP \u50c5\u5728\u65e9\u671f\u6291\u5236 IAV \u8907\u88fd\u3002 \u25cf NS1\u548cNP\u7684\u904e\u8868\u9054\u6291\u5236ZAPS\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 \u25cf NS1 \u901a\u904e\u964d\u4f4e\u5176 RNA \u7d50\u5408\u6d3b\u6027\u4f86\u62ee\u6297 ZAPS\u3002 \u25cf \u651c\u5e36 NS1-m7 \u7684\u91cd\u7d44 IAV \u5728 ZAPS \u7f3a\u9677\u7d30\u80de\u4e2d\u5fa9\u88fd\u5f97\u66f4\u597d\u3002 \u5728\u8a72\u7814\u7a76\u5831\u544a\u4e2d\u5217\u51fa\u5be6\u9a57\u7684\u4ee5\u4e0b\u5e7e\u500b\u3010\u8a0e\u8ad6\u3011\uff1a \u25cf IAV \u7684\u611f\u67d3\u8a98\u5c0e\u4e86 IFN \u4ecb\u5c0e\u7684\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u901a\u904e\u4fc3\u9032 PB2 \u548c PA \u7684\u86cb\u767d\u9176\u9ad4\u964d\u89e3\u4f86\u6291\u5236 IAV \u7684\u8907\u5236\u3002ZAPS \u8f49\u9304\u5f8c\u6291\u5236 IAV \u86cb\u767d\u8868\u9054\u3002 \u25cf \u70ba\u4e86\u5efa\u7acb\u6709\u6548\u7684\u611f\u67d3\uff0c\u75c5\u6bd2\u9700\u8981\u767c\u5c55\u6a5f\u5236\u4f86\u62b5\u6d88\u514d\u75ab\u53cd\u61c9\u3002ZAPL \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab PB1 \u62ee\u6297\u3002ZAPS \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab NS1 \u62ee\u6297\u3002 \u25cf \u5be6\u9a57\u7d50\u679c\u986f\u793aNS1 \u901a\u904e\u6e1b\u5c11\u5176\u8207\u6a19\u9776 RNA \u7684\u7d50\u5408\u4f86\u62ee\u6297 ZAP\u3002\u7d50\u679c\u8868\u660e NS1 \u4e0d\u6703\u901a\u904e\u8207 ZAPS \u7af6\u722d\u7d50\u5408\u6a19\u9776 RNA \u4f86\u62ee\u6297 ZAPS\u3002NS1 \u5982\u4f55\u964d\u4f4e ZAP \u7684 RNA \u7d50\u5408\u6d3b\u6027\uff0c\u5c1a\u4e0d\u6e05\u695a\u3002 \u25cf \u5be6\u9a57\u986f\u793a\u9020\u6210\u5931\u53bb ZAPS-\u62ee\u6297\u6d3b\u6027\u7684\u662f NS1 \u7a81\u8b8a\u9ad4 NS1-m7 \u548c NS1-m9\u3002\u56e0\u6b64\u662fNS1 \u5982\u4f55\u964d\u4f4eZAPS-\u62ee\u6297\u6d3b\u6027\u7684\u95dc\u9375\u56e0\u7d20\u3002\u5176\u6a5f\u8f49\u539f\u56e0\u5c1a\u4e0d\u6e05\u695a\u3002 \u25cf \u7d50\u8ad6\u4e00\uff1aZAPS \u5728\u611f\u67d3\u7684\u65e9\u671f\u968e\u6bb5\u78ba\u5be6\u80fd\u6291\u5236 IAV \u8907\u88fd\uff0c\u81f3\u5c11\u90e8\u5206\u662f\u901a\u904e\u8f49\u9304\u5f8c\u6291\u5236 PA\u3001PB2 \u548c NA \u7684\u8868\u9054\u3002 \u25cf \u7d50\u8ad6\u4e8c\uff1a\u4f46\u662fZAP \u7684\u9019\u7a2e\u6297\u75c5\u6bd2\u6d3b\u6027\u88ab\u75c5\u6bd2\u7de8\u78bc\u7684 NS1 \u62ee\u6297\uff0c\u5c0d NS1 \u62ee\u6297 ZAPS 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