{"id":457068,"date":"2026-07-27T18:10:00","date_gmt":"2026-07-27T10:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=457068"},"modified":"2026-07-27T18:10:00","modified_gmt":"2026-07-27T10:10:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e5%b8%83%e6%af%8f%e6%9c%88%e4%b8%80%e6%ac%a1%e7%9a%ae%e4%b8%8b%e6%b3%a8%e5%b0%84glp-1r-gipr-gcgr%e4%b8%89%e9%9d%b6%e9%bb%9e%e6%bf%80%e5%8b%95%e5%8a%91%e5%a4%9a%e8%82%bdasc3","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=457068","title":{"rendered":"\u6b4c\u79ae\u5ba3\u5e03\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

–\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08<\/i>DIO<\/i>\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c<\/i>ASC37<\/i>\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u5347<\/i>88%<\/i>\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002<\/i><\/p>\n

–ASC37<\/i>\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\uff08<\/i>SQ<\/i>\uff09\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u5747\u5c07\u901a\u904e\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08<\/i>BLA<\/i>\uff09\u8def\u5f91\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/i>FDA<\/i>\uff09\u905e\u4ea4\u4e0a\u5e02\u7533\u5831\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2026\u5e747\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u65b0\u4e00\u4ee3GLP-1R\/GIPR\/GCGR[1]<\/sup>\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\uff0c\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u4e86\u512a\u65bc\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u4ee51 nmol\/kg\u7684\u76f8\u540c\u5291\u91cf\u7d66\u85e511\u5929\u5f8c\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u5728DIO\u5c0f\u9f20\u4e2d\uff0cASC37\u5be6\u73fe\u4e86\u9ad8\u905441.5%\u7684\u9ad4\u91cd\u4e0b\u964d\uff08\u88681\uff09\uff0c\u4e14\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u3002<\/p>\n

<\/div>\n

\u88681. \u7d66\u85e511\u5929\u5f8c\uff0cASC37\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u6e1b\u91cd\u6548\u679c\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027<\/p>\n

\u00a0<\/p>\n

\n\n\n\n\n\n\n\n
\n

\u7d66\u85e5<\/span><\/p>\n<\/td>\n

\n

\u76f8\u8f03\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316<\/span><\/p>\n<\/td>\n

\n

\u8f03\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d
\u63d0\u5347<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 nmol\/kg \u66ff\u723e\u6cca\u80bd<\/span><\/p>\n

\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

-7.5\u00a0%<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1 nmol\/kg ASC37<\/span><\/p>\n

\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

-14.1\u00a0%<\/span><\/p>\n<\/td>\n

\n

88%<\/span><\/p>\n

(p <\/i>= 0.0279 vs \u66ff\u723e\u6cca\u80bd)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

10 nmol\/kg ASC37<\/span><\/p>\n

\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

-30.1\u00a0%<\/span><\/p>\n<\/td>\n

\n

301%<\/span><\/p>\n

(p <\/i>< 0.0001 vs \u66ff\u723e\u6cca\u80bd)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

30 nmol\/kg ASC37<\/span><\/p>\n

\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

-41.5\u00a0%<\/span><\/p>\n<\/td>\n

\n

453%<\/span><\/p>\n

(p <\/i>< 0.0001 vs \u66ff\u723e\u6cca\u80bd)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u00a0<\/p>\n

\u6ce8\u91cb<\/i>\uff1aDIO\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20<\/p>\n

\u7d93\u7cbe\u6e96\u5b9a\u5411\u8a2d\u8a08\uff0cASC37\u5305\u542b41\u500b\u03b1-\u6c28\u57fa\u9178\uff0c\u7b26\u5408\u751f\u7269\u5236\u54c1\u8cc7\u683c\u3002ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u905e\u4ea4\u3002ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u7684\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u5c07\u5728III\u671f\u81e8\u5e8a\u5b8c\u6210\u5f8c\u5411FDA\u905e\u4ea4\u3002\u65b0\u4e00\u4ee3GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC35\u540c\u6a23\u542b\u670941\u500b\u03b1-\u6c28\u57fa\u9178\uff0c\u4e5f\u5c07\u901a\u904e\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u7684\u8def\u5f91\u9032\u884c\u4e0a\u5e02\u7533\u5831\u3002<\/p>\n

\u8207\u53e6\u4e00\u6b3e\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdretatrutide\u76f8\u6bd4\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHP\uff09\u7814\u7a76\u4e2d\uff0cASC37\u76ae\u4e0b\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\uff08SALD\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba17\u5929\uff0c\u800cretatrutide\u70ba2.5\u5929\u3002ASC37\u9019\u4e00\u7d047\u500d\u65bcretatrutide\u7684\u534a\u8870\u671f\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u6216\u66f4\u4f4e\u7684\u7d66\u85e5\u983b\u7387\u3002<\/p>\n

\u300c\u57fa\u65bc\u9019\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u524d\u6578\u64da\uff0c\u6211\u5011\u76f8\u4fe1ASC37\u6709\u671b\u6210\u70ba\u7528\u65bc\u91cd\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u4e26\u4e14\u9084\u5177\u6709\u901a\u904eBLA\u6ce8\u518a\u8def\u5f91\u7533\u5831\u7684\u984d\u5916\u512a\u52e2\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u53d6\u5f97\u751f\u7269\u5236\u54c1\u8cc7\u683c\u70baASC37\u63d0\u4f9b\u8af8\u591a\u512a\u52e2<\/span>\uff0c\u5305\u62ec\u8207\u5c0f\u5206\u5b50\u85e5\u7269\u76f8\u6bd4\uff0c\u4eab\u6709\u66f4\u9577\u7684\u6cd5\u5b9a\u5e02\u5834\u7368\u5360\u671f\u4ee5\u53ca\u514d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u5f71\u97ff\u7684\u66f4\u9577\u4fdd\u8b77\u671f\u3002\u300d<\/p>\n

\u6839\u64da\u300a\u901a\u8139\u524a\u6e1b\u6cd5\u6848\u300b\uff08Inflation Reduction Act\uff09\uff0c\u751f\u7269\u5236\u54c1\u5728FDA\u6279\u51c6\u5f8c\u4eab\u6709\u9577\u905413\u5e74\u7684\u50f9\u683c\u8ac7\u5224\u8c41\u514d\u671f\uff08\u800c\u4e0d\u662f\u5c0f\u5206\u5b50\u85e5\u7269\u76849\u5e74\uff09\uff0c\u800c\u5f8c\u624d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u7d04\u675f\u3002\u6b64\u5916\uff0c\u76e3\u7ba1\u8def\u5f91\u4e0d\u5141\u8a31\u7b2c\u4e09\u65b9\u85e5\u623f\u5c0d\u751f\u7269\u5236\u54c1\u9032\u884c\u4eff\u5236\u914d\u5236\uff08compound\uff09\u3002\u9019\u9650\u5236\u4e86\u914d\u85e5\u623f\uff08compounding pharmacy\uff09\u63d0\u4f9b\u4f4e\u50f9\u7248ASC37\u548cASC35\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\n\n\n\n
\n

[1]<\/sup>\u00a0GLP-1R\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff0cGIPR\uff1a\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u4fc3\u80f0\u5cf6\u7d20\u591a\u80bd\u53d7\u9ad4\uff0cGCGR\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u00a0<\/p>\n

\u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8<\/b><\/p>\n

\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u548cASC30_48 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC48\uff08GIP RA\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002<\/p>\n

\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com<\/a>\u3002<\/p>\n

\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

Peter Vozzo
ICR Healthcare
443-231-0505 (\u7f8e\u570b)
Peter.vozzo@icrhealthcare.com<\/a>\u00a0<\/p>\n

\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a
+86-181-0650-9129 (\u4e2d\u570b)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

–\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08…<\/p>\n","protected":false},"author":16,"featured_media":457069,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-457068","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u6b4c\u79ae\u5ba3\u5e03\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" 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\u7d66\u85e511\u5929\u5f8c\uff0cASC37\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u6e1b\u91cd\u6548\u679c\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u00a0 \u7d66\u85e5 \u76f8\u8f03\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 1 nmol\/kg \u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -7.5\u00a0% - 1 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -14.1\u00a0% 88%(p = 0.0279 vs \u66ff\u723e\u6cca\u80bd) 10 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -30.1\u00a0% 301%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) 30 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -41.5\u00a0% 453%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) \u00a0 \u6ce8\u91cb\uff1aDIO\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20 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\u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u548cASC30_48 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC48\uff08GIP RA\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.com ir@ascletis.com\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=457068\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u5ba3\u5e03\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"-\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002 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nmol\/kg\u7684\u76f8\u540c\u5291\u91cf\u7d66\u85e511\u5929\u5f8c\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u5728DIO\u5c0f\u9f20\u4e2d\uff0cASC37\u5be6\u73fe\u4e86\u9ad8\u905441.5%\u7684\u9ad4\u91cd\u4e0b\u964d\uff08\u88681\uff09\uff0c\u4e14\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u3002 \u88681. \u7d66\u85e511\u5929\u5f8c\uff0cASC37\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u6e1b\u91cd\u6548\u679c\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u00a0 \u7d66\u85e5 \u76f8\u8f03\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 1 nmol\/kg \u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -7.5\u00a0% - 1 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -14.1\u00a0% 88%(p = 0.0279 vs \u66ff\u723e\u6cca\u80bd) 10 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -30.1\u00a0% 301%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) 30 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -41.5\u00a0% 453%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) \u00a0 \u6ce8\u91cb\uff1aDIO\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20 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\u8207\u53e6\u4e00\u6b3e\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdretatrutide\u76f8\u6bd4\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHP\uff09\u7814\u7a76\u4e2d\uff0cASC37\u76ae\u4e0b\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\uff08SALD\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba17\u5929\uff0c\u800cretatrutide\u70ba2.5\u5929\u3002ASC37\u9019\u4e00\u7d047\u500d\u65bcretatrutide\u7684\u534a\u8870\u671f\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u6216\u66f4\u4f4e\u7684\u7d66\u85e5\u983b\u7387\u3002 \u300c\u57fa\u65bc\u9019\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u524d\u6578\u64da\uff0c\u6211\u5011\u76f8\u4fe1ASC37\u6709\u671b\u6210\u70ba\u7528\u65bc\u91cd\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u4e26\u4e14\u9084\u5177\u6709\u901a\u904eBLA\u6ce8\u518a\u8def\u5f91\u7533\u5831\u7684\u984d\u5916\u512a\u52e2\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u53d6\u5f97\u751f\u7269\u5236\u54c1\u8cc7\u683c\u70baASC37\u63d0\u4f9b\u8af8\u591a\u512a\u52e2\uff0c\u5305\u62ec\u8207\u5c0f\u5206\u5b50\u85e5\u7269\u76f8\u6bd4\uff0c\u4eab\u6709\u66f4\u9577\u7684\u6cd5\u5b9a\u5e02\u5834\u7368\u5360\u671f\u4ee5\u53ca\u514d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u5f71\u97ff\u7684\u66f4\u9577\u4fdd\u8b77\u671f\u3002\u300d \u6839\u64da\u300a\u901a\u8139\u524a\u6e1b\u6cd5\u6848\u300b\uff08Inflation Reduction Act\uff09\uff0c\u751f\u7269\u5236\u54c1\u5728FDA\u6279\u51c6\u5f8c\u4eab\u6709\u9577\u905413\u5e74\u7684\u50f9\u683c\u8ac7\u5224\u8c41\u514d\u671f\uff08\u800c\u4e0d\u662f\u5c0f\u5206\u5b50\u85e5\u7269\u76849\u5e74\uff09\uff0c\u800c\u5f8c\u624d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u7d04\u675f\u3002\u6b64\u5916\uff0c\u76e3\u7ba1\u8def\u5f91\u4e0d\u5141\u8a31\u7b2c\u4e09\u65b9\u85e5\u623f\u5c0d\u751f\u7269\u5236\u54c1\u9032\u884c\u4eff\u5236\u914d\u5236\uff08compound\uff09\u3002\u9019\u9650\u5236\u4e86\u914d\u85e5\u623f\uff08compounding pharmacy\uff09\u63d0\u4f9b\u4f4e\u50f9\u7248ASC37\u548cASC35\u7684\u53ef\u80fd\u6027\u3002 \u00a0GLP-1R\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff0cGIPR\uff1a\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u4fc3\u80f0\u5cf6\u7d20\u591a\u80bd\u53d7\u9ad4\uff0cGCGR\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4 \u00a0 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u548cASC30_48 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC48\uff08GIP RA\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.com ir@ascletis.com\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=457068\" \/>\n<meta property=\"og:site_name\" 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nmol\\\/kg\u7684\u76f8\u540c\u5291\u91cf\u7d66\u85e511\u5929\u5f8c\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u5728DIO\u5c0f\u9f20\u4e2d\uff0cASC37\u5be6\u73fe\u4e86\u9ad8\u905441.5%\u7684\u9ad4\u91cd\u4e0b\u964d\uff08\u88681\uff09\uff0c\u4e14\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u3002 \u88681. \u7d66\u85e511\u5929\u5f8c\uff0cASC37\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u6e1b\u91cd\u6548\u679c\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u00a0 \u7d66\u85e5 \u76f8\u8f03\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 1 nmol\\\/kg \u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -7.5\u00a0% - 1 nmol\\\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -14.1\u00a0% 88%(p = 0.0279 vs \u66ff\u723e\u6cca\u80bd) 10 nmol\\\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -30.1\u00a0% 301%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) 30 nmol\\\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -41.5\u00a0% 453%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) \u00a0 \u6ce8\u91cb\uff1aDIO\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20 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\u8207\u53e6\u4e00\u6b3e\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdretatrutide\u76f8\u6bd4\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHP\uff09\u7814\u7a76\u4e2d\uff0cASC37\u76ae\u4e0b\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\uff08SALD\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba17\u5929\uff0c\u800cretatrutide\u70ba2.5\u5929\u3002ASC37\u9019\u4e00\u7d047\u500d\u65bcretatrutide\u7684\u534a\u8870\u671f\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u6216\u66f4\u4f4e\u7684\u7d66\u85e5\u983b\u7387\u3002 \u300c\u57fa\u65bc\u9019\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u524d\u6578\u64da\uff0c\u6211\u5011\u76f8\u4fe1ASC37\u6709\u671b\u6210\u70ba\u7528\u65bc\u91cd\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u4e26\u4e14\u9084\u5177\u6709\u901a\u904eBLA\u6ce8\u518a\u8def\u5f91\u7533\u5831\u7684\u984d\u5916\u512a\u52e2\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u53d6\u5f97\u751f\u7269\u5236\u54c1\u8cc7\u683c\u70baASC37\u63d0\u4f9b\u8af8\u591a\u512a\u52e2\uff0c\u5305\u62ec\u8207\u5c0f\u5206\u5b50\u85e5\u7269\u76f8\u6bd4\uff0c\u4eab\u6709\u66f4\u9577\u7684\u6cd5\u5b9a\u5e02\u5834\u7368\u5360\u671f\u4ee5\u53ca\u514d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u5f71\u97ff\u7684\u66f4\u9577\u4fdd\u8b77\u671f\u3002\u300d \u6839\u64da\u300a\u901a\u8139\u524a\u6e1b\u6cd5\u6848\u300b\uff08Inflation Reduction Act\uff09\uff0c\u751f\u7269\u5236\u54c1\u5728FDA\u6279\u51c6\u5f8c\u4eab\u6709\u9577\u905413\u5e74\u7684\u50f9\u683c\u8ac7\u5224\u8c41\u514d\u671f\uff08\u800c\u4e0d\u662f\u5c0f\u5206\u5b50\u85e5\u7269\u76849\u5e74\uff09\uff0c\u800c\u5f8c\u624d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u7d04\u675f\u3002\u6b64\u5916\uff0c\u76e3\u7ba1\u8def\u5f91\u4e0d\u5141\u8a31\u7b2c\u4e09\u65b9\u85e5\u623f\u5c0d\u751f\u7269\u5236\u54c1\u9032\u884c\u4eff\u5236\u914d\u5236\uff08compound\uff09\u3002\u9019\u9650\u5236\u4e86\u914d\u85e5\u623f\uff08compounding pharmacy\uff09\u63d0\u4f9b\u4f4e\u50f9\u7248ASC37\u548cASC35\u7684\u53ef\u80fd\u6027\u3002 \u00a0GLP-1R\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff0cGIPR\uff1a\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u4fc3\u80f0\u5cf6\u7d20\u591a\u80bd\u53d7\u9ad4\uff0cGCGR\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4 \u00a0 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement 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\u6839\u64da\u300a\u901a\u8139\u524a\u6e1b\u6cd5\u6848\u300b\uff08Inflation Reduction Act\uff09\uff0c\u751f\u7269\u5236\u54c1\u5728FDA\u6279\u51c6\u5f8c\u4eab\u6709\u9577\u905413\u5e74\u7684\u50f9\u683c\u8ac7\u5224\u8c41\u514d\u671f\uff08\u800c\u4e0d\u662f\u5c0f\u5206\u5b50\u85e5\u7269\u76849\u5e74\uff09\uff0c\u800c\u5f8c\u624d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u7d04\u675f\u3002\u6b64\u5916\uff0c\u76e3\u7ba1\u8def\u5f91\u4e0d\u5141\u8a31\u7b2c\u4e09\u65b9\u85e5\u623f\u5c0d\u751f\u7269\u5236\u54c1\u9032\u884c\u4eff\u5236\u914d\u5236\uff08compound\uff09\u3002\u9019\u9650\u5236\u4e86\u914d\u85e5\u623f\uff08compounding pharmacy\uff09\u63d0\u4f9b\u4f4e\u50f9\u7248ASC37\u548cASC35\u7684\u53ef\u80fd\u6027\u3002 \u00a0GLP-1R\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff0cGIPR\uff1a\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u4fc3\u80f0\u5cf6\u7d20\u591a\u80bd\u53d7\u9ad4\uff0cGCGR\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4 \u00a0 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u548cASC30_48 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC48\uff08GIP RA\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.com ir@ascletis.com\u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=457068","og_locale":"zh_TW","og_type":"article","og_title":"\u6b4c\u79ae\u5ba3\u5e03\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"-\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002 -ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\uff08SQ\uff09\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u5747\u5c07\u901a\u904e\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u8def\u5f91\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4\u4e0a\u5e02\u7533\u5831\u3002 \u9999\u6e2f2026\u5e747\u670827\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u65b0\u4e00\u4ee3GLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\uff0c\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u4e86\u512a\u65bc\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u4ee51 nmol\/kg\u7684\u76f8\u540c\u5291\u91cf\u7d66\u85e511\u5929\u5f8c\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u5728DIO\u5c0f\u9f20\u4e2d\uff0cASC37\u5be6\u73fe\u4e86\u9ad8\u905441.5%\u7684\u9ad4\u91cd\u4e0b\u964d\uff08\u88681\uff09\uff0c\u4e14\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u3002 \u88681. \u7d66\u85e511\u5929\u5f8c\uff0cASC37\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u6e1b\u91cd\u6548\u679c\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u00a0 \u7d66\u85e5 \u76f8\u8f03\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 1 nmol\/kg \u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -7.5\u00a0% - 1 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -14.1\u00a0% 88%(p = 0.0279 vs \u66ff\u723e\u6cca\u80bd) 10 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -30.1\u00a0% 301%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) 30 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -41.5\u00a0% 453%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) \u00a0 \u6ce8\u91cb\uff1aDIO\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20 \u7d93\u7cbe\u6e96\u5b9a\u5411\u8a2d\u8a08\uff0cASC37\u5305\u542b41\u500b\u03b1-\u6c28\u57fa\u9178\uff0c\u7b26\u5408\u751f\u7269\u5236\u54c1\u8cc7\u683c\u3002ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u905e\u4ea4\u3002ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u7684\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u5c07\u5728III\u671f\u81e8\u5e8a\u5b8c\u6210\u5f8c\u5411FDA\u905e\u4ea4\u3002\u65b0\u4e00\u4ee3GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC35\u540c\u6a23\u542b\u670941\u500b\u03b1-\u6c28\u57fa\u9178\uff0c\u4e5f\u5c07\u901a\u904e\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u7684\u8def\u5f91\u9032\u884c\u4e0a\u5e02\u7533\u5831\u3002 \u8207\u53e6\u4e00\u6b3e\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdretatrutide\u76f8\u6bd4\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHP\uff09\u7814\u7a76\u4e2d\uff0cASC37\u76ae\u4e0b\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\uff08SALD\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba17\u5929\uff0c\u800cretatrutide\u70ba2.5\u5929\u3002ASC37\u9019\u4e00\u7d047\u500d\u65bcretatrutide\u7684\u534a\u8870\u671f\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u6216\u66f4\u4f4e\u7684\u7d66\u85e5\u983b\u7387\u3002 \u300c\u57fa\u65bc\u9019\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u81e8\u5e8a\u524d\u6578\u64da\uff0c\u6211\u5011\u76f8\u4fe1ASC37\u6709\u671b\u6210\u70ba\u7528\u65bc\u91cd\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u4e26\u4e14\u9084\u5177\u6709\u901a\u904eBLA\u6ce8\u518a\u8def\u5f91\u7533\u5831\u7684\u984d\u5916\u512a\u52e2\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u53d6\u5f97\u751f\u7269\u5236\u54c1\u8cc7\u683c\u70baASC37\u63d0\u4f9b\u8af8\u591a\u512a\u52e2\uff0c\u5305\u62ec\u8207\u5c0f\u5206\u5b50\u85e5\u7269\u76f8\u6bd4\uff0c\u4eab\u6709\u66f4\u9577\u7684\u6cd5\u5b9a\u5e02\u5834\u7368\u5360\u671f\u4ee5\u53ca\u514d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u5f71\u97ff\u7684\u66f4\u9577\u4fdd\u8b77\u671f\u3002\u300d \u6839\u64da\u300a\u901a\u8139\u524a\u6e1b\u6cd5\u6848\u300b\uff08Inflation Reduction Act\uff09\uff0c\u751f\u7269\u5236\u54c1\u5728FDA\u6279\u51c6\u5f8c\u4eab\u6709\u9577\u905413\u5e74\u7684\u50f9\u683c\u8ac7\u5224\u8c41\u514d\u671f\uff08\u800c\u4e0d\u662f\u5c0f\u5206\u5b50\u85e5\u7269\u76849\u5e74\uff09\uff0c\u800c\u5f8c\u624d\u53d7\u653f\u5e9c\u50f9\u683c\u8ac7\u5224\u7d04\u675f\u3002\u6b64\u5916\uff0c\u76e3\u7ba1\u8def\u5f91\u4e0d\u5141\u8a31\u7b2c\u4e09\u65b9\u85e5\u623f\u5c0d\u751f\u7269\u5236\u54c1\u9032\u884c\u4eff\u5236\u914d\u5236\uff08compound\uff09\u3002\u9019\u9650\u5236\u4e86\u914d\u85e5\u623f\uff08compounding pharmacy\uff09\u63d0\u4f9b\u4f4e\u50f9\u7248ASC37\u548cASC35\u7684\u53ef\u80fd\u6027\u3002 \u00a0GLP-1R\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff0cGIPR\uff1a\u8461\u8404\u7cd6\u4f9d\u8cf4\u6027\u4fc3\u80f0\u5cf6\u7d20\u591a\u80bd\u53d7\u9ad4\uff0cGCGR\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4 \u00a0 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u548cASC30_48 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC48\uff08GIP RA\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.com ir@ascletis.com\u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=457068","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2026-07-27T10:10:00+00:00","og_image":[{"width":3000,"height":1990,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 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-ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\uff08SQ\uff09\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u5747\u5c07\u901a\u904e\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u8def\u5f91\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4\u4e0a\u5e02\u7533\u5831\u3002 \u9999\u6e2f2026\u5e747\u670827\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u65b0\u4e00\u4ee3GLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC37\uff0c\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u4e86\u512a\u65bc\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u3002\u5728DIO\u5c0f\u9f20\u4e2d\uff0c\u4ee51 nmol\/kg\u7684\u76f8\u540c\u5291\u91cf\u7d66\u85e511\u5929\u5f8c\uff0cASC37\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u534788%\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u5728DIO\u5c0f\u9f20\u4e2d\uff0cASC37\u5be6\u73fe\u4e86\u9ad8\u905441.5%\u7684\u9ad4\u91cd\u4e0b\u964d\uff08\u88681\uff09\uff0c\u4e14\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u3002 \u88681. \u7d66\u85e511\u5929\u5f8c\uff0cASC37\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u6e1b\u91cd\u6548\u679c\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u00a0 \u7d66\u85e5 \u76f8\u8f03\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03\u66ff\u723e\u6cca\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 1 nmol\/kg \u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -7.5\u00a0% - 1 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -14.1\u00a0% 88%(p = 0.0279 vs \u66ff\u723e\u6cca\u80bd) 10 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -30.1\u00a0% 301%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) 30 nmol\/kg ASC37\u76ae\u4e0b\uff0c\u6bcf\u65e5\u4e00\u6b21 -41.5\u00a0% 453%(p < 0.0001 vs \u66ff\u723e\u6cca\u80bd) \u00a0 \u6ce8\u91cb\uff1aDIO\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20 \u7d93\u7cbe\u6e96\u5b9a\u5411\u8a2d\u8a08\uff0cASC37\u5305\u542b41\u500b\u03b1-\u6c28\u57fa\u9178\uff0c\u7b26\u5408\u751f\u7269\u5236\u54c1\u8cc7\u683c\u3002ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u905e\u4ea4\u3002ASC37\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u5236\u5291\u548c\u53e3\u670d\u5236\u5291\u7684\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u5c07\u5728III\u671f\u81e8\u5e8a\u5b8c\u6210\u5f8c\u5411FDA\u905e\u4ea4\u3002\u65b0\u4e00\u4ee3GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC35\u540c\u6a23\u542b\u670941\u500b\u03b1-\u6c28\u57fa\u9178\uff0c\u4e5f\u5c07\u901a\u904e\u751f\u7269\u5236\u54c1\u8a31\u53ef\u7533\u8acb\uff08BLA\uff09\u7684\u8def\u5f91\u9032\u884c\u4e0a\u5e02\u7533\u5831\u3002 \u8207\u53e6\u4e00\u6b3e\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdretatrutide\u76f8\u6bd4\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHP\uff09\u7814\u7a76\u4e2d\uff0cASC37\u76ae\u4e0b\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\uff08SALD\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba17\u5929\uff0c\u800cretatrutide\u70ba2.5\u5929\u3002ASC37\u9019\u4e00\u7d047\u500d\u65bcretatrutide\u7684\u534a\u8870\u671f\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u6216\u66f4\u4f4e\u7684\u7d66\u85e5\u983b\u7387\u3002 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