{"id":447562,"date":"2026-06-23T18:10:00","date_gmt":"2026-06-23T10:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=447562"},"modified":"2026-06-23T18:10:00","modified_gmt":"2026-06-23T10:10:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%85%b6%e6%af%8f%e6%9c%88%e4%b8%80%e6%ac%a1%e7%9a%ae%e4%b8%8b%e6%b3%a8%e5%b0%84glp-1r-gipr%e9%9b%99%e9%9d%b6%e9%bb%9e%e6%bf%80%e5%8b%95%e5%8a%91%e5%a4%9a%e8%82%bd","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=447562","title":{"rendered":"\u6b4c\u79ae\u5ba3\u4f48\u5176\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC35\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u7814\u7a76IND\u7372\u7f8e\u570bFDA\u6279\u51c6"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

–\u00a0 I<\/i>\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002<\/i>A<\/i>\u90e8\u5206\u70ba<\/i>ASC35<\/i>\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08<\/i>Self-Assembling Lipid Depot<\/i>\uff0c<\/i>SALD<\/i>\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08<\/i>SAD<\/i>\uff09\u7814\u7a76\uff1b<\/i>B<\/i>\u90e8\u5206\u70ba<\/i>ASC35 SALD<\/span><\/i>\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/i>FDA<\/i>\uff09\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08<\/i>MAD<\/i>\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002<\/i><\/p>\n

–\u00a0 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0c<\/i>ASC35<\/i>\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08<\/i>observed half-life<\/i>\uff09\u7d04\u6bd4\u66ff\u723e\u6cca\u80bd\u9577<\/i>6<\/i>\u500d\uff0c\u652f\u6301\u5728\u4eba\u9ad4\u4e2d\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\u3002<\/i><\/p>\n

–\u00a0 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08<\/i>DIO<\/i>\uff09\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0c<\/i>ASC35<\/i>\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u5347\u7d04<\/i>71%<\/i>\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2026\u5e746\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u8fd1\u671f\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5c0d\u5176ASC35\u7684I\u671f\u7814\u7a76\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff08IND\uff09\u6279\u51c6\u3002ASC35\u662f\u4e00\u6b3e\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\/GIP\u53d7\u9ad4\uff08GIPR\uff09\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u3002<\/p>\n

\n<\/p><\/div>\n

\u8a72I\u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30ASC35\u572884\u540d\u80a5\u80d6\uff08\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\u226530.0 kg\/m\u00b2\uff09\u6216\u4f34\u6709\u9ad4\u91cd\u76f8\u95dc\u5408\u4f75\u75c7\u7684\u8d85\u91cd\uff08BMI\u226527.0 kg\/m\u00b2\uff09\u53d7\u8a66\u8005\u4e2d\uff0c\u55ae\u5291\u91cf\u548c\u591a\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u52d5\u529b\u5b78\u3002\u8a72I\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002A\u90e8\u5206\u70baASC35\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08SALD\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff1bB\u90e8\u5206\u70baASC35 SALD<\/span>\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570bFDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002<\/p>\n

ASC35\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08AISBDD\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u3002ASC35 SALD<\/span>\u6708\u5236\u5291\u662f\u5229\u7528\u6b4c\u79ae\u7684\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08ULAP\uff09\u6280\u8853\u958b\u767c\u7684\u3002<\/p>\n

SALD\u5236\u5291\u662f\u4e00\u7a2e\u4f4e\u7c98\u5ea6\u6eb6\u6db2\uff0c\u7531\u8102\u8cea\u3001\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u7684\u6709\u6a5f\u6eb6\u5291\u548c\u6d3b\u6027\u85e5\u7269\u6210\u5206\uff08API\uff09\u7d44\u6210\u3002\u9019\u7a2e\u4f4e\u7c98\u5ea6\u6eb6\u6db2\u53ef\u4ee5\u4f7f\u7528\u914d\u6709\u7d30\u81f329G\uff08gauge\uff09\u91dd\u982d\u7684\u6ce8\u5c04\u7b46\u6216\u81ea\u52d5\u6ce8\u5c04\u5668\uff0c\u8f15\u9b06\u6ce8\u5165\u76ae\u4e0b\u7d44\u7e54\u3002\u76ae\u4e0b\u6ce8\u5c04\u5f8c\uff0c\u8a72\u6eb6\u6db2\u5728\u7d44\u7e54\u4e2d\u6703\u8f49\u5316\u70ba\u51dd\u81a0\u72c0\u7684\u5132\u5eab\uff08depot\uff09\u3002\u5728\u76ae\u4e0b\u7d44\u7e54\u7684\u751f\u7269\u9176\u4f5c\u7528\u4e0b\uff0c\u8a72\u5132\u5eab\u6703\u7de9\u6162\u964d\u89e3\uff0c\u5f9e\u800c\u63a7\u5236API\u5728\u4e00\u500b\u6708\u6216\u66f4\u9577\u7684\u6642\u9593\u5167\u6301\u7e8c\u91cb\u653e\u3002<\/p>\n

\u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0c\u76ae\u4e0b\u6ce8\u5c04\u7684ASC35 SALD\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u6bd4FDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\u5236\u5291\u95776\u500d\u3002\u8207\u5176\u5b83\u8178\u4fc3\u80f0\u7d20\u591a\u80bd\u76f8\u6bd4\uff0cASC35\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u53ca\u66f4\u5e73\u7de9\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u9019\u4e9b\u512a\u52e2\u4e5f\u53ef\u80fd\u4f7f\u5176\u5728\u4eba\u9ad4\u4e2d\u5177\u6709\u66f4\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u3002<\/p>\n

\u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC35\u975c\u8108\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u5f8c\u7684\u85e5\u7269\u66b4\u9732\u91cf\u6bd4\u66ff\u723e\u6cca\u80bd\u975c\u8108\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u5206\u5225\u9ad8\u7d0480%\u548c70%\u3002<\/p>\n

\u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC35\u548c\u66ff\u723e\u6cca\u80bd\uff0cASC35\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u5347\u905471%\u3002<\/p>\n

\u9ad4\u5916\u5be6\u9a57\u986f\u793a\uff0cASC35\u5c0dGLP-1R\u548cGIPR\u7684\u6fc0\u52d5\u6d3b\u6027\u6bd4\u66ff\u723e\u6cca\u80bd\u5f37\u7d044\u500d\u3002\u7d50\u5408\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\uff0cASC35\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u7642\u6548\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff08more efficient on a per-milligram peptide basis\uff09\u3002<\/p>\n

\u300c\u5229\u7528\u672c\u516c\u53f8\u5c08\u6709\u7684SALD\u5236\u5291\u6280\u8853\u7814\u767c\u7684ASC35\u6708\u5236\u5291\u7372FDA\u6279\u51c6\u958b\u5c55\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff0c\u662f\u6b4c\u79ae\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u591a\u80bd\u7ba1\u7dda\u7684\u4e00\u9805\u6fc0\u52d5\u4eba\u5fc3\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u7576\u524d\uff0c\u6211\u5011\u6b63\u5728\u63a8\u9032\u591a\u6b3e\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u591a\u80bd\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC35\u5353\u8d8a\u7684\u6e1b\u91cd\u6f5b\u529b\uff0c\u7d50\u5408\u66f4\u9748\u6d3b\u4e14\u5c0d\u60a3\u8005\u53cb\u597d\u7684\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u65b9\u5f0f\uff0c\u5c07\u6709\u671b\u89e3\u6c7a\u5feb\u901f\u589e\u9577\u7684\u80a5\u80d6\u75c7\u5e02\u5834\u4e2d\u672a\u88ab\u6eff\u8db3\u7684\u91cd\u5927\u9700\u6c42\u3002\u300d<\/p>\n

\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/b><\/p>\n

\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u548cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002<\/p>\n

\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com<\/a>\u3002<\/p>\n

\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

Peter Vozzo
ICR Healthcare
443-231-0505 (\u7f8e\u570b)
Peter.vozzo@icrhealthcare.com<\/a>\u00a0<\/p>\n

\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a
+86-181-0650-9129 (\u4e2d\u570b)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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\u9ad4\u5916\u5be6\u9a57\u986f\u793a\uff0cASC35\u5c0dGLP-1R\u548cGIPR\u7684\u6fc0\u52d5\u6d3b\u6027\u6bd4\u66ff\u723e\u6cca\u80bd\u5f37\u7d044\u500d\u3002\u7d50\u5408\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\uff0cASC35\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u7642\u6548\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff08more efficient on a per-milligram peptide basis\uff09\u3002 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\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u548cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=447562\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u5ba3\u4f48\u5176\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC35\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u7814\u7a76IND\u7372\u7f8e\u570bFDA\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"-\u00a0 I\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002A\u90e8\u5206\u70baASC35\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08Self-Assembling Lipid Depot\uff0cSALD\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff1bB\u90e8\u5206\u70baASC35 SALD\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002 -\u00a0 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\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u8fd1\u671f\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5c0d\u5176ASC35\u7684I\u671f\u7814\u7a76\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff08IND\uff09\u6279\u51c6\u3002ASC35\u662f\u4e00\u6b3e\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\/GIP\u53d7\u9ad4\uff08GIPR\uff09\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u8a72I\u671f\u8a66\u9a57\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30ASC35\u572884\u540d\u80a5\u80d6\uff08\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\u226530.0 kg\/m\u00b2\uff09\u6216\u4f34\u6709\u9ad4\u91cd\u76f8\u95dc\u5408\u4f75\u75c7\u7684\u8d85\u91cd\uff08BMI\u226527.0 kg\/m\u00b2\uff09\u53d7\u8a66\u8005\u4e2d\uff0c\u55ae\u5291\u91cf\u548c\u591a\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u52d5\u529b\u5b78\u3002\u8a72I\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002A\u90e8\u5206\u70baASC35\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08SALD\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff1bB\u90e8\u5206\u70baASC35 SALD\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570bFDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002 ASC35\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08AISBDD\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u3002ASC35 SALD\u6708\u5236\u5291\u662f\u5229\u7528\u6b4c\u79ae\u7684\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08ULAP\uff09\u6280\u8853\u958b\u767c\u7684\u3002 SALD\u5236\u5291\u662f\u4e00\u7a2e\u4f4e\u7c98\u5ea6\u6eb6\u6db2\uff0c\u7531\u8102\u8cea\u3001\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u7684\u6709\u6a5f\u6eb6\u5291\u548c\u6d3b\u6027\u85e5\u7269\u6210\u5206\uff08API\uff09\u7d44\u6210\u3002\u9019\u7a2e\u4f4e\u7c98\u5ea6\u6eb6\u6db2\u53ef\u4ee5\u4f7f\u7528\u914d\u6709\u7d30\u81f329G\uff08gauge\uff09\u91dd\u982d\u7684\u6ce8\u5c04\u7b46\u6216\u81ea\u52d5\u6ce8\u5c04\u5668\uff0c\u8f15\u9b06\u6ce8\u5165\u76ae\u4e0b\u7d44\u7e54\u3002\u76ae\u4e0b\u6ce8\u5c04\u5f8c\uff0c\u8a72\u6eb6\u6db2\u5728\u7d44\u7e54\u4e2d\u6703\u8f49\u5316\u70ba\u51dd\u81a0\u72c0\u7684\u5132\u5eab\uff08depot\uff09\u3002\u5728\u76ae\u4e0b\u7d44\u7e54\u7684\u751f\u7269\u9176\u4f5c\u7528\u4e0b\uff0c\u8a72\u5132\u5eab\u6703\u7de9\u6162\u964d\u89e3\uff0c\u5f9e\u800c\u63a7\u5236API\u5728\u4e00\u500b\u6708\u6216\u66f4\u9577\u7684\u6642\u9593\u5167\u6301\u7e8c\u91cb\u653e\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0c\u76ae\u4e0b\u6ce8\u5c04\u7684ASC35 SALD\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u6bd4FDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\u5236\u5291\u95776\u500d\u3002\u8207\u5176\u5b83\u8178\u4fc3\u80f0\u7d20\u591a\u80bd\u76f8\u6bd4\uff0cASC35\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u53ca\u66f4\u5e73\u7de9\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u9019\u4e9b\u512a\u52e2\u4e5f\u53ef\u80fd\u4f7f\u5176\u5728\u4eba\u9ad4\u4e2d\u5177\u6709\u66f4\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC35\u975c\u8108\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u5f8c\u7684\u85e5\u7269\u66b4\u9732\u91cf\u6bd4\u66ff\u723e\u6cca\u80bd\u975c\u8108\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u5206\u5225\u9ad8\u7d0480%\u548c70%\u3002 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC35\u548c\u66ff\u723e\u6cca\u80bd\uff0cASC35\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u5347\u905471%\u3002 \u9ad4\u5916\u5be6\u9a57\u986f\u793a\uff0cASC35\u5c0dGLP-1R\u548cGIPR\u7684\u6fc0\u52d5\u6d3b\u6027\u6bd4\u66ff\u723e\u6cca\u80bd\u5f37\u7d044\u500d\u3002\u7d50\u5408\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\uff0cASC35\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u7642\u6548\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff08more efficient on a per-milligram peptide basis\uff09\u3002 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\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement 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kg\/m\u00b2\uff09\u6216\u4f34\u6709\u9ad4\u91cd\u76f8\u95dc\u5408\u4f75\u75c7\u7684\u8d85\u91cd\uff08BMI\u226527.0 kg\/m\u00b2\uff09\u53d7\u8a66\u8005\u4e2d\uff0c\u55ae\u5291\u91cf\u548c\u591a\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u52d5\u529b\u5b78\u3002\u8a72I\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002A\u90e8\u5206\u70baASC35\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08SALD\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff1bB\u90e8\u5206\u70baASC35 SALD\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570bFDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002 ASC35\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08AISBDD\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u3002ASC35 SALD\u6708\u5236\u5291\u662f\u5229\u7528\u6b4c\u79ae\u7684\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08ULAP\uff09\u6280\u8853\u958b\u767c\u7684\u3002 SALD\u5236\u5291\u662f\u4e00\u7a2e\u4f4e\u7c98\u5ea6\u6eb6\u6db2\uff0c\u7531\u8102\u8cea\u3001\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\u7684\u6709\u6a5f\u6eb6\u5291\u548c\u6d3b\u6027\u85e5\u7269\u6210\u5206\uff08API\uff09\u7d44\u6210\u3002\u9019\u7a2e\u4f4e\u7c98\u5ea6\u6eb6\u6db2\u53ef\u4ee5\u4f7f\u7528\u914d\u6709\u7d30\u81f329G\uff08gauge\uff09\u91dd\u982d\u7684\u6ce8\u5c04\u7b46\u6216\u81ea\u52d5\u6ce8\u5c04\u5668\uff0c\u8f15\u9b06\u6ce8\u5165\u76ae\u4e0b\u7d44\u7e54\u3002\u76ae\u4e0b\u6ce8\u5c04\u5f8c\uff0c\u8a72\u6eb6\u6db2\u5728\u7d44\u7e54\u4e2d\u6703\u8f49\u5316\u70ba\u51dd\u81a0\u72c0\u7684\u5132\u5eab\uff08depot\uff09\u3002\u5728\u76ae\u4e0b\u7d44\u7e54\u7684\u751f\u7269\u9176\u4f5c\u7528\u4e0b\uff0c\u8a72\u5132\u5eab\u6703\u7de9\u6162\u964d\u89e3\uff0c\u5f9e\u800c\u63a7\u5236API\u5728\u4e00\u500b\u6708\u6216\u66f4\u9577\u7684\u6642\u9593\u5167\u6301\u7e8c\u91cb\u653e\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0c\u76ae\u4e0b\u6ce8\u5c04\u7684ASC35 SALD\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u6bd4FDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u76ae\u4e0b\u5236\u5291\u95776\u500d\u3002\u8207\u5176\u5b83\u8178\u4fc3\u80f0\u7d20\u591a\u80bd\u76f8\u6bd4\uff0cASC35\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u53ca\u66f4\u5e73\u7de9\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u9019\u4e9b\u512a\u52e2\u4e5f\u53ef\u80fd\u4f7f\u5176\u5728\u4eba\u9ad4\u4e2d\u5177\u6709\u66f4\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC35\u975c\u8108\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u5f8c\u7684\u85e5\u7269\u66b4\u9732\u91cf\u6bd4\u66ff\u723e\u6cca\u80bd\u975c\u8108\u6ce8\u5c04\u548c\u76ae\u4e0b\u6ce8\u5c04\u5206\u5225\u9ad8\u7d0480%\u548c70%\u3002 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC35\u548c\u66ff\u723e\u6cca\u80bd\uff0cASC35\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u5347\u905471%\u3002 \u9ad4\u5916\u5be6\u9a57\u986f\u793a\uff0cASC35\u5c0dGLP-1R\u548cGIPR\u7684\u6fc0\u52d5\u6d3b\u6027\u6bd4\u66ff\u723e\u6cca\u80bd\u5f37\u7d044\u500d\u3002\u7d50\u5408\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\uff0cASC35\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u7642\u6548\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff08more efficient on a per-milligram peptide basis\uff09\u3002 \u300c\u5229\u7528\u672c\u516c\u53f8\u5c08\u6709\u7684SALD\u5236\u5291\u6280\u8853\u7814\u767c\u7684ASC35\u6708\u5236\u5291\u7372FDA\u6279\u51c6\u958b\u5c55\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff0c\u662f\u6b4c\u79ae\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u591a\u80bd\u7ba1\u7dda\u7684\u4e00\u9805\u6fc0\u52d5\u4eba\u5fc3\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u7576\u524d\uff0c\u6211\u5011\u6b63\u5728\u63a8\u9032\u591a\u6b3e\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u591a\u80bd\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC35\u5353\u8d8a\u7684\u6e1b\u91cd\u6f5b\u529b\uff0c\u7d50\u5408\u66f4\u9748\u6d3b\u4e14\u5c0d\u60a3\u8005\u53cb\u597d\u7684\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u65b9\u5f0f\uff0c\u5c07\u6709\u671b\u89e3\u6c7a\u5feb\u901f\u589e\u9577\u7684\u80a5\u80d6\u75c7\u5e02\u5834\u4e2d\u672a\u88ab\u6eff\u8db3\u7684\u91cd\u5927\u9700\u6c42\u3002\u300d \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u548cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=447562","og_locale":"zh_TW","og_type":"article","og_title":"\u6b4c\u79ae\u5ba3\u4f48\u5176\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bdASC35\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u7814\u7a76IND\u7372\u7f8e\u570bFDA\u6279\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"-\u00a0 I\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002A\u90e8\u5206\u70baASC35\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08Self-Assembling Lipid Depot\uff0cSALD\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff1bB\u90e8\u5206\u70baASC35 SALD\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002 -\u00a0 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC35\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u6bd4\u66ff\u723e\u6cca\u80bd\u95776\u500d\uff0c\u652f\u6301\u5728\u4eba\u9ad4\u4e2d\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\u3002 -\u00a0 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0cASC35\u7684\u6e1b\u91cd\u6548\u679c\u8f03\u66ff\u723e\u6cca\u80bd\u76f8\u5c0d\u63d0\u5347\u7d0471%\u3002 \u9999\u6e2f2026\u5e746\u670823\u65e5 \/\u7f8e\u901a\u793e\/ -- 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kg\/m\u00b2\uff09\u6216\u4f34\u6709\u9ad4\u91cd\u76f8\u95dc\u5408\u4f75\u75c7\u7684\u8d85\u91cd\uff08BMI\u226527.0 kg\/m\u00b2\uff09\u53d7\u8a66\u8005\u4e2d\uff0c\u55ae\u5291\u91cf\u548c\u591a\u5291\u91cf\u905e\u589e\u7d66\u85e5\u5f8c\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u52d5\u529b\u5b78\u3002\u8a72I\u671f\u8a66\u9a57\u5206\u70ba\u5169\u90e8\u5206\u3002A\u90e8\u5206\u70baASC35\u81ea\u7d44\u88dd\u8102\u8cea\u5132\u5eab\u578b\uff08SALD\uff09\u6708\u5236\u5291\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff1bB\u90e8\u5206\u70baASC35 SALD\u6708\u5236\u5291\u5c0d\u6bd4\u7f8e\u570bFDA\u6279\u51c6\u7684\u66ff\u723e\u6cca\u80bd\u5468\u5236\u5291\u7684\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u982d\u5c0d\u982d\u7814\u7a76\u3002 ASC35\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08AISBDD\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u3002ASC35 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\u9ad4\u5916\u5be6\u9a57\u986f\u793a\uff0cASC35\u5c0dGLP-1R\u548cGIPR\u7684\u6fc0\u52d5\u6d3b\u6027\u6bd4\u66ff\u723e\u6cca\u80bd\u5f37\u7d044\u500d\u3002\u7d50\u5408\u6240\u6709\u81e8\u5e8a\u524d\u7814\u7a76\uff0cASC35\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u7642\u6548\u512a\u65bc\u66ff\u723e\u6cca\u80bd\uff08more efficient on a per-milligram peptide basis\uff09\u3002 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\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u548cASC30_39 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