{"id":447327,"date":"2026-06-22T21:06:00","date_gmt":"2026-06-22T13:06:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=447327"},"modified":"2026-06-22T21:06:00","modified_gmt":"2026-06-22T13:06:00","slug":"%e8%98%86%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%96%ae%e6%8a%97%e8%81%af%e5%90%88%e5%a5%a7%e5%b8%8c%e6%9b%bf%e5%b0%bc%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82egfr%e7%aa%81%e8%ae%8ansclc%e8%bd%89%e5%8c%96","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=447327","title":{"rendered":"\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8aNSCLC\u8f49\u5316\u7814\u7a76\u6210\u679c\u520a\u767c\u65bc\u300aCancer Cell\u300b"},"content":{"rendered":"
\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

– \u8a72\u7814\u7a76\u8b49\u5be6\uff0cEGFR-TKI\u53ef\u8a98\u5c0eDTP\u7d30\u80deTROP2\u4e0a\u8abf\uff0c\u70basac-TMT\u8207EGFR-TKI\u806f\u5408\u7528\u85e5\u63d0\u4f9b\u6a5f\u5236\u4f9d\u64da\u3002<\/p>\n

– \u516c\u53f8\u6b63\u5728\u958b\u5c55\u5169\u9805\u81e8\u5e8a\u8a66\u9a57\uff1asac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u665a\u671fEGFR\u7a81\u8b8aNSCLC\u7684III\u671f\u6ce8\u518a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\u53d7\u8a66\u8005\u5165\u7d44\uff0c\u73fe\u8655\u65bc\u96a8\u8a2a\u968e\u6bb5\uff09\uff1b\u4ee5\u53ca\u8a72\u806f\u5408\u65b9\u6848\u7528\u65bc\u53ef\u5207\u9664EGFR\u7a81\u8b8aNSCLC\u65b0\u8f14\u52a9\u6cbb\u7642\u7684II\u671f\u7814\u7a76\u3002<\/p>\n

– sac-TMT\u5df2\u5728\u4e2d\u570b\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93TKI\u55ae\u85e5\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u6216\u7d93TKI\u806f\u5408\u542b\u9251\u5316\u7642\u5f8c\u9032\u5c55\u7684\u665a\u671fEGFR\u7a81\u8b8aNSCLC\uff0c\u4e14\u5728TKI\u8010\u85e5\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u986f\u8457PFS\u8207OS\u7372\u76ca\u3002<\/p>\n

\u6210\u90fd<\/span>2026\u5e746\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d\uff09\u5ba3\u5e03\uff0c\u65d7\u4e0b\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\uff08sac-TMT\uff0c\u7814\u767c\u4ee3\u865f\uff1aSKB264\/MK-2870\uff0c\u5546\u54c1\u540d\uff1a\u4f73\u6cf0\u840a\u00ae<\/sup>\uff09\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(EGFR)\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684\u8f49\u5316\u7814\u7a76\u6210\u679c\u5df2\u5728\u7dda\u767c\u8868\u65bc\u570b\u969b\u5b78\u8853\u671f\u520a\u300a<\/i>Cancer Cell<\/i>\u300b<\/i>\u3002<\/p>\n

\n

\"\"<\/a>
<\/span><\/p>\n<\/p><\/div>\n

\u8a72\u8ad6\u6587\u984c\u70ba\u300cTargeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer\u300d\uff0c\u7531\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f35\u529b\u6559\u6388\u3001\u65b9\u6587\u5cf0\u6559\u6388\u5718\u968a\u727d\u982d\u5b8c\u6210\u3002\u7814\u7a76\u986f\u793a\uff0c\u7d93EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291(TKI)\u6cbb\u7642\u5f8c\uff0c\u6b98\u5b58\u7684\u85e5\u7269\u8010\u53d7\u6301\u4e45\u6027\u7d30\u80de(DTP)\u6703\u51fa\u73fe\u6ecb\u990a\u5c64\u7d30\u80de\u8868\u9762\u6297\u539f2(TROP2)\u8868\u9054\u4e0a\u8abf\uff1b\u81e8\u5e8a\u524d\u6a21\u578b\u8b49\u5be6\uff0csac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u53ef\u6291\u5236DTP\u7d30\u80de\u5f62\u6210\u4e26\u5ef6\u7de9\u816b\u7624\u5fa9\u767c\u3002\u4e0a\u8ff0\u7814\u7a76\u7d50\u679c\u70ba\u9776\u5411TROP2\u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u8207EGFR-TKI\u806f\u5408\u7528\u65bc\u5ef6\u7de9\u8010\u85e5\u63d0\u4f9b\u4e86\u8f49\u5316\u91ab\u5b78\u8b49\u64da\uff0c\u9032\u4e00\u6b65\u51f8\u986fsac-TMT\u4f5c\u70baEGFR-TKI\u6838\u5fc3\u806f\u5408\u7528\u85e5\u642d\u6a94\u7684\u5dee\u7570\u5316\u50f9\u503c\u3002<\/p>\n

\u57fa\u65bc\u4e0a\u8ff0\u7814\u7a76\u6210\u679c\u8207\u81e8\u5e8a\u958b\u767c\u8a08\u5283\uff0c\u516c\u53f8\u6b63\u5728\u63a8\u9032\u4e00\u9805III\u671f\u6ce8\u518a\u7814\u7a76\uff08\u8a66\u9a57\u7de8\u865f\uff1aNCT06670196\uff09\uff0c\u5c07sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u8207\u5967\u5e0c\u66ff\u5c3c\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8a\u975e\u9c57\u72c0NSCLC\u9032\u884c\u5c0d\u6bd4\u3002\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30sac-TMT\uff084 mg\/kg\uff0c\u6bcf\u5169\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u76f8\u8f03\u65bc\u5967\u5e0c\u66ff\u5c3c\u55ae\u85e5\u5728\u6b64\u9069\u61c9\u75c7\u4e0b\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u5df2\u5728\u4e2d\u570b\u5b8c\u6210\u5168\u90e8\u53d7\u8a66\u8005\u5165\u7d44\uff0c\u76ee\u524d\u9032\u5165\u96a8\u8a2a\u8207\u6578\u64da\u6210\u719f\u968e\u6bb5\u3002<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u516c\u53f8\u9084\u5728\u63a8\u9032sac-TMT\u7528\u65bc\u66f4\u65e9\u671fEGFR\u7a81\u8b8aNSCLC\u7684\u81e8\u5e8a\u63a2\u7d22\u3002\u4e00\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\uff08\u8a66\u9a57\u7de8\u865f\uff1aNCT07329322\uff09\u6b63\u5728\u958b\u5c55\uff0c\u8a55\u4f30sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u6216sac-TMT\u55ae\u85e5\u7528\u65bc\u53ef\u5207\u9664EGFR\u7a81\u8b8aNSCLC\u65b0\u8f14\u52a9\u6cbb\u7642\uff0c\u9032\u4e00\u6b65\u6316\u6398sac-TMT\u5728\u570d\u624b\u8853\u671f\u6cbb\u7642\u4e2d\u7684\u6f5b\u5728\u50f9\u503c\u3002<\/p>\n

\u672c\u6b21\u7814\u7a76\u6210\u679c\u520a\u767c\u65bc\u300a<\/i>Cancer Cell<\/i>\u300b<\/i>\u592f\u5be6\u4e86sac-TMT\u806f\u5408EGFR-TKI\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8aNSCLC\u7684\u79d1\u5b78\u7406\u8ad6\u57fa\u790e\u3002\u4f9d\u6258sac-TMT\u5728EGFR\u7a81\u8b8aNSCLC\u9818\u57df\u5df2\u7372\u6279\u7684\u9069\u61c9\u75c7\u53ca\u81e8\u5e8a\u958b\u767c\u8a08\u5283\uff0c\u516c\u53f8\u5c07\u6301\u7e8c\u63a2\u7d22\u8a72\u806f\u5408\u65b9\u6848\u5728\u524d\u7dda\u6cbb\u7642\u3001\u8010\u85e5\u5ef6\u7de9\u3001\u9577\u671f\u751f\u5b58\u7372\u76ca\u7b49\u65b9\u9762\u7684\u61c9\u7528\u6f5b\u529b\u3002\u79d1\u502b\u535a\u6cf0\u5c07\u6301\u7e8c\u6df1\u8015EGFR\u7a81\u8b8aNSCLC\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u7684\u7814\u767c\uff0c\u70ba\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n

\u95dc\u65bc<\/u><\/b>sac-TMT<\/u><\/b>\uff08\u4f73\u6cf0\u840a<\/u><\/b>\u00ae<\/sup><\/u><\/b>\uff09<\/u><\/b><\/p>\n

\u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0csac-TMT\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u65b0\u578b\u4eba\u6e90\u5316TROP2 ADC\uff0c\u9069\u61c9\u75c7\u8986\u84cbNSCLC\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u3001\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7d71\u816b\u7624\u7b49\u591a\u7a2e\u665a\u671f\u5be6\u9ad4\u7624\u3002sac-TMT\u91c7\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u958b\u767c\u800c\u6210\uff1a\u4e00\u7aef\u8207\u6297TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u4e0d\u53ef\u9006\u7d50\u5408\uff0c\u53e6\u4e00\u7aef\u53ef\u5728\u6eb6\u9176\u9ad4\u5167\u767c\u751fpH\u4f9d\u8cf4\u6027\u88c2\u89e3\uff0c\u91cb\u653e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u8f09\u8377\uff0c\u5f9e\u800c\u6700\u5927\u9650\u5ea6\u5730\u5c07\u6bd2\u6027\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u90547.4\u3002sac-TMT\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762TROP2\uff0c\u7d93\u816b\u7624\u7d30\u80de\u5167\u541e\u5f8c\uff0c\u5728\u7d30\u80de\u5167\u91cb\u653e\u6bd2\u6027\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u5468\u671f\u963b\u6eef\u8207\u51cb\u4ea1\u3002\u6b64\u5916\uff0cKL610023\u6703\u88ab\u91cb\u653e\u81f3\u816b\u7624\u5fae\u74b0\u5883\u3002\u7531\u65bcKL610023\u5177\u5099\u7d30\u80de\u819c\u7a7f\u900f\u6027\uff0c\u53ef\u7522\u751f\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u6bba\u50b7\u5468\u908a\u816b\u7624\u7d30\u80de\u3002<\/p>\n

2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771\uff08\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f\uff09\u5728\u5927\u4e2d\u83ef\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u53f0\u7063\uff09\u4ee5\u5916\u7684\u5168\u7403\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u5236\u9020\u53ca\u5546\u696d\u5316sac-TMT\u7684\u7368\u5bb6\u6b0a\u5229\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0csac-TMT\u5728\u4e2d\u570b\u5df2\u7372\u6279\u56db\u9805\u9069\u61c9\u75c7\u4e26\u5be6\u73fe\u5546\u696d\u5316\u4e0a\u5e02\uff1a1)\u65e2\u5f80\u63a5\u53d7\u81f3\u5c11\u5169\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c11\u4e00\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\/\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c(TNBC)\uff1b2)\u7d93EGFR-TKI\u806f\u5408\u542b\u9251\u5316\u7642\u5f8c\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b3)\u7d93EGFR-TKI\u55ae\u85e5\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b4)\u65e2\u5f80\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u665a\u671f\u968e\u6bb5\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027(HR+)\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad42\u9670\u6027\uff08HER2-\uff0c\u514d\u75ab\u7d44\u7e54\u5316\u5b78(IHC) 0\u3001IHC 1+\u6216IHC 2+\/\u539f\u4f4d\u96dc\u4ea4(ISH)-) BC\u3002\u4e0a\u8ff0\u524d\u5169\u9805\u9069\u61c9\u75c7\u5df2\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304(NRDL)\uff0c\u6709\u671b\u70ba\u66f4\u591aBC\u548cNSCLC\u60a3\u8005\u5e36\u4f86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u3002\u540c\u6642\uff0csac-TMT\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6388\u4e88\u516d\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002<\/p>\n

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\u95dc\u65bc\u79d1\u502b\u535a\u6cf0<\/u><\/b><\/p>\n

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\n\n\n\n
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[1]<\/sup>\u53ef\u745e\u9054\u00ae<\/sup>\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u662f\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u65d7\u4e0b\u5b50\u516c\u53f8\u9ed8\u6c99\u6771(MSD)\u7684\u6ce8\u518a\u5546\u6a19\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u00a0<\/p>\n

<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

– \u8a72\u7814\u7a76\u8b49\u5be6\uff0cE…<\/p>\n","protected":false},"author":16,"featured_media":447328,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-447327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8aNSCLC\u8f49\u5316\u7814\u7a76\u6210\u679c\u520a\u767c\u65bc\u300aCancer Cell\u300b - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"- \u8a72\u7814\u7a76\u8b49\u5be6\uff0cEGFR-TKI\u53ef\u8a98\u5c0eDTP\u7d30\u80deTROP2\u4e0a\u8abf\uff0c\u70basac-TMT\u8207EGFR-TKI\u806f\u5408\u7528\u85e5\u63d0\u4f9b\u6a5f\u5236\u4f9d\u64da\u3002 - 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sac-TMT\u5df2\u5728\u4e2d\u570b\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93TKI\u55ae\u85e5\u6cbb\u7642\u5f8c\u9032\u5c55\u3001\u6216\u7d93TKI\u806f\u5408\u542b\u9251\u5316\u7642\u5f8c\u9032\u5c55\u7684\u665a\u671fEGFR\u7a81\u8b8aNSCLC\uff0c\u4e14\u5728TKI\u8010\u85e5\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u986f\u8457PFS\u8207OS\u7372\u76ca\u3002 \u6210\u90fd2026\u5e746\u670822\u65e5 \/\u7f8e\u901a\u793e\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d\uff09\u5ba3\u5e03\uff0c\u65d7\u4e0b\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\uff08sac-TMT\uff0c\u7814\u767c\u4ee3\u865f\uff1aSKB264\/MK-2870\uff0c\u5546\u54c1\u540d\uff1a\u4f73\u6cf0\u840a\u00ae\uff09\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(EGFR)\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684\u8f49\u5316\u7814\u7a76\u6210\u679c\u5df2\u5728\u7dda\u767c\u8868\u65bc\u570b\u969b\u5b78\u8853\u671f\u520a\u300aCancer Cell\u300b\u3002 \u8a72\u8ad6\u6587\u984c\u70ba\u300cTargeting TROP2 in drug-tolerant persister cells delays EGFR tyrosine kinase inhibitor resistance in non-small-cell lung cancer\u300d\uff0c\u7531\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f35\u529b\u6559\u6388\u3001\u65b9\u6587\u5cf0\u6559\u6388\u5718\u968a\u727d\u982d\u5b8c\u6210\u3002\u7814\u7a76\u986f\u793a\uff0c\u7d93EGFR\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291(TKI)\u6cbb\u7642\u5f8c\uff0c\u6b98\u5b58\u7684\u85e5\u7269\u8010\u53d7\u6301\u4e45\u6027\u7d30\u80de(DTP)\u6703\u51fa\u73fe\u6ecb\u990a\u5c64\u7d30\u80de\u8868\u9762\u6297\u539f2(TROP2)\u8868\u9054\u4e0a\u8abf\uff1b\u81e8\u5e8a\u524d\u6a21\u578b\u8b49\u5be6\uff0csac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u53ef\u6291\u5236DTP\u7d30\u80de\u5f62\u6210\u4e26\u5ef6\u7de9\u816b\u7624\u5fa9\u767c\u3002\u4e0a\u8ff0\u7814\u7a76\u7d50\u679c\u70ba\u9776\u5411TROP2\u6297\u9ad4\u85e5\u7269\u5076\u806f\u7269(ADC)\u8207EGFR-TKI\u806f\u5408\u7528\u65bc\u5ef6\u7de9\u8010\u85e5\u63d0\u4f9b\u4e86\u8f49\u5316\u91ab\u5b78\u8b49\u64da\uff0c\u9032\u4e00\u6b65\u51f8\u986fsac-TMT\u4f5c\u70baEGFR-TKI\u6838\u5fc3\u806f\u5408\u7528\u85e5\u642d\u6a94\u7684\u5dee\u7570\u5316\u50f9\u503c\u3002 \u57fa\u65bc\u4e0a\u8ff0\u7814\u7a76\u6210\u679c\u8207\u81e8\u5e8a\u958b\u767c\u8a08\u5283\uff0c\u516c\u53f8\u6b63\u5728\u63a8\u9032\u4e00\u9805III\u671f\u6ce8\u518a\u7814\u7a76\uff08\u8a66\u9a57\u7de8\u865f\uff1aNCT06670196\uff09\uff0c\u5c07sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u8207\u5967\u5e0c\u66ff\u5c3c\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8a\u975e\u9c57\u72c0NSCLC\u9032\u884c\u5c0d\u6bd4\u3002\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30sac-TMT\uff084 mg\/kg\uff0c\u6bcf\u5169\u5468\u7d66\u85e5\u4e00\u6b21\uff09\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u76f8\u8f03\u65bc\u5967\u5e0c\u66ff\u5c3c\u55ae\u85e5\u5728\u6b64\u9069\u61c9\u75c7\u4e0b\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u5df2\u5728\u4e2d\u570b\u5b8c\u6210\u5168\u90e8\u53d7\u8a66\u8005\u5165\u7d44\uff0c\u76ee\u524d\u9032\u5165\u96a8\u8a2a\u8207\u6578\u64da\u6210\u719f\u968e\u6bb5\u3002 \u9664\u6b64\u4e4b\u5916\uff0c\u516c\u53f8\u9084\u5728\u63a8\u9032sac-TMT\u7528\u65bc\u66f4\u65e9\u671fEGFR\u7a81\u8b8aNSCLC\u7684\u81e8\u5e8a\u63a2\u7d22\u3002\u4e00\u9805II\u671f\u81e8\u5e8a\u7814\u7a76\uff08\u8a66\u9a57\u7de8\u865f\uff1aNCT07329322\uff09\u6b63\u5728\u958b\u5c55\uff0c\u8a55\u4f30sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u6216sac-TMT\u55ae\u85e5\u7528\u65bc\u53ef\u5207\u9664EGFR\u7a81\u8b8aNSCLC\u65b0\u8f14\u52a9\u6cbb\u7642\uff0c\u9032\u4e00\u6b65\u6316\u6398sac-TMT\u5728\u570d\u624b\u8853\u671f\u6cbb\u7642\u4e2d\u7684\u6f5b\u5728\u50f9\u503c\u3002 \u672c\u6b21\u7814\u7a76\u6210\u679c\u520a\u767c\u65bc\u300aCancer Cell\u300b\u592f\u5be6\u4e86sac-TMT\u806f\u5408EGFR-TKI\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8aNSCLC\u7684\u79d1\u5b78\u7406\u8ad6\u57fa\u790e\u3002\u4f9d\u6258sac-TMT\u5728EGFR\u7a81\u8b8aNSCLC\u9818\u57df\u5df2\u7372\u6279\u7684\u9069\u61c9\u75c7\u53ca\u81e8\u5e8a\u958b\u767c\u8a08\u5283\uff0c\u516c\u53f8\u5c07\u6301\u7e8c\u63a2\u7d22\u8a72\u806f\u5408\u65b9\u6848\u5728\u524d\u7dda\u6cbb\u7642\u3001\u8010\u85e5\u5ef6\u7de9\u3001\u9577\u671f\u751f\u5b58\u7372\u76ca\u7b49\u65b9\u9762\u7684\u61c9\u7528\u6f5b\u529b\u3002\u79d1\u502b\u535a\u6cf0\u5c07\u6301\u7e8c\u6df1\u8015EGFR\u7a81\u8b8aNSCLC\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u7684\u7814\u767c\uff0c\u70ba\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcsac-TMT\uff08\u4f73\u6cf0\u840a\u00ae\uff09 \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0csac-TMT\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u65b0\u578b\u4eba\u6e90\u5316TROP2 ADC\uff0c\u9069\u61c9\u75c7\u8986\u84cbNSCLC\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u3001\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7d71\u816b\u7624\u7b49\u591a\u7a2e\u665a\u671f\u5be6\u9ad4\u7624\u3002sac-TMT\u91c7\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u958b\u767c\u800c\u6210\uff1a\u4e00\u7aef\u8207\u6297TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u4e0d\u53ef\u9006\u7d50\u5408\uff0c\u53e6\u4e00\u7aef\u53ef\u5728\u6eb6\u9176\u9ad4\u5167\u767c\u751fpH\u4f9d\u8cf4\u6027\u88c2\u89e3\uff0c\u91cb\u653e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u8f09\u8377\uff0c\u5f9e\u800c\u6700\u5927\u9650\u5ea6\u5730\u5c07\u6bd2\u6027\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u90547.4\u3002sac-TMT\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762TROP2\uff0c\u7d93\u816b\u7624\u7d30\u80de\u5167\u541e\u5f8c\uff0c\u5728\u7d30\u80de\u5167\u91cb\u653e\u6bd2\u6027\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u5468\u671f\u963b\u6eef\u8207\u51cb\u4ea1\u3002\u6b64\u5916\uff0cKL610023\u6703\u88ab\u91cb\u653e\u81f3\u816b\u7624\u5fae\u74b0\u5883\u3002\u7531\u65bcKL610023\u5177\u5099\u7d30\u80de\u819c\u7a7f\u900f\u6027\uff0c\u53ef\u7522\u751f\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u6bba\u50b7\u5468\u908a\u816b\u7624\u7d30\u80de\u3002 2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771\uff08\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f\uff09\u5728\u5927\u4e2d\u83ef\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u53f0\u7063\uff09\u4ee5\u5916\u7684\u5168\u7403\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u5236\u9020\u53ca\u5546\u696d\u5316sac-TMT\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0csac-TMT\u5728\u4e2d\u570b\u5df2\u7372\u6279\u56db\u9805\u9069\u61c9\u75c7\u4e26\u5be6\u73fe\u5546\u696d\u5316\u4e0a\u5e02\uff1a1)\u65e2\u5f80\u63a5\u53d7\u81f3\u5c11\u5169\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c11\u4e00\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\/\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c(TNBC)\uff1b2)\u7d93EGFR-TKI\u806f\u5408\u542b\u9251\u5316\u7642\u5f8c\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b3)\u7d93EGFR-TKI\u55ae\u85e5\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b4)\u65e2\u5f80\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u665a\u671f\u968e\u6bb5\u81f3\u5c11\u63a5\u53d7\u904e\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027(HR+)\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad42\u9670\u6027\uff08HER2-\uff0c\u514d\u75ab\u7d44\u7e54\u5316\u5b78(IHC) 0\u3001IHC 1+\u6216IHC 2+\/\u539f\u4f4d\u96dc\u4ea4(ISH)-) BC\u3002\u4e0a\u8ff0\u524d\u5169\u9805\u9069\u61c9\u75c7\u5df2\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304(NRDL)\uff0c\u6709\u671b\u70ba\u66f4\u591aBC\u548cNSCLC\u60a3\u8005\u5e36\u4f86\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u751f\u5b58\u7372\u76ca\u3002\u540c\u6642\uff0csac-TMT\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6388\u4e88\u516d\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 sac-TMT\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u9818\u57df\u7372\u6279\u4e0a\u5e02\u7684TROP2 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