{"id":443080,"date":"2026-06-08T08:10:00","date_gmt":"2026-06-08T00:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=443080"},"modified":"2026-06-08T08:10:00","modified_gmt":"2026-06-08T00:10:00","slug":"%e6%ad%8c%e7%a6%aeasc30%e8%87%a8%e5%ba%8a%e6%95%b8%e6%93%9a%e8%88%87asc37%e3%80%81asc39%e4%bb%a4%e4%ba%ba%e6%8c%af%e5%a5%ae%e7%9a%84%e8%87%a8%e5%ba%8a%e5%89%8d%e7%b5%90%e6%9e%9c%e6%96%bc%e7%be%8e","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=443080","title":{"rendered":"\u6b4c\u79aeASC30\u81e8\u5e8a\u6578\u64da\u8207ASC37\u3001ASC39\u4ee4\u4eba\u632f\u596e\u7684\u81e8\u5e8a\u524d\u7d50\u679c\u65bc\u7f8e\u570b\u7cd6\u5c3f\u75c5\u5354\u6703\uff08ADA\uff092026\u5e74\u5ea6\u79d1\u5b78\u6703\u8b70\u9f4a\u4eae\u76f8\uff0c\u592f\u5be6\u5dee\u7570\u5316\u80a5\u80d6\u7ba1\u7dda"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u9999\u6e2f<\/span>2026\u5e746\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u4e09\u9805\u95dc\u9375\u7814\u7a76\u5728\u7f8e\u570b\u7cd6\u5c3f\u75c5\u5354\u6703\uff08ADA\uff092026\u5e74\u5ea6\u79d1\u5b78\u6703\u8b70\uff082026\u5e746\u67085\u65e5\u81f38\u65e5\uff0c\u65bc\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5967\u723e\u826f\u8209\u884c\uff09\u4e0a\u4eae\u76f8\uff0c\u91cd\u9ede\u5c55\u793a\u4e86\u5176\u5728\u80a5\u80d6\u6cbb\u7642\u9818\u57df\u5dee\u7570\u5316\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u5c0f\u5206\u5b50\u5019\u9078\u85e5\u7269\u3001\u4e00\u6b3e\u591a\u80bd\u85e5\u7269\u4ee5\u53ca\u4e00\u9805\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\u3002\u76f8\u95dc\u6578\u64da\u5f15\u8d77\u4e86\u8207\u6703\u5c08\u5bb6<\/span>\u7684\u6975\u5927\u95dc\u6ce8\uff0c\u4e26\u9032\u4e00\u6b65\u5f70\u986f\u4e86\u6b4c\u79ae\u5728\u4ee3\u8b1d\u6027\u75be\u75c5\u7642\u6cd5\u9818\u57df\u7684\u5275\u65b0\u80fd\u529b\u3002<\/p>\n

<\/div>\n

\u6838\u5fc3\u6578\u64da<\/b><\/p>\n

1. \u5f37\u6548\u53e3\u670d\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff1aASC39<\/b><\/p>\n

\u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0cASC39\u5c0d\u4eba\u80f0\u6fb1\u7d201\u578b\u53d7\u9ad4\uff08hAMY1R\uff09\u7684\u9078\u64c7\u6027\u8207eloralintide\u7684\u76f8\u7576\uff0c\u4e14\u5176\u5c0d\u80f0\u6fb1\u7d20\u53d7\u9ad4\u7684\u89aa\u548c\u529b\uff08affinity\uff09\u986f\u8457\u9ad8\u65bc\u5c0d\u4eba\u964d\u9223\u7d20\u53d7\u9ad4\uff08hCTR\uff09\u7684\u89aa\u548c\u529b\u3002\u9019\u7a2e\u53d7\u9ad4\u9078\u64c7\u6027\u53ef\u80fd\u6709\u52a9\u65bc\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u7531\u964d\u9223\u7d20\u53d7\u9ad4\u4ecb\u5c0e\u7684\u4e2d\u6a1e\u4e0d\u826f\u53cd\u61c9\uff0c\u4f8b\u5982\u5641\u5fc3\u548c\u904e\u5ea6\u98df\u617e\u6291\u5236\u3002<\/p>\n

\u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u6a21\u578b\u4e2d\uff0cASC39\u4ee50.2 mg\/kg\u30011 mg\/kg\u548c5 mg\/kg\u7684\u5291\u91cf\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u3002\u7814\u7a76\u89c0\u5bdf\u5230\u9ad4\u91cd\u4e0b\u964d\u5448\u660e\u986f\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\uff08dose-dependent\uff09\u3002\u5728\u7b2c11\u5929\u6642\uff0c\u63a5\u53d75 mg\/kg ASC39\u6cbb\u7642\u7684\u52d5\u7269\u9ad4\u91cd\u8f03\u57fa\u7dda\u4e0b\u964d\u4e869.9%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u7684\u4e0b\u964d\u4e862.8%\uff08p<\/i> < 0.01\uff09\u3002<\/p>\n

\u5728\u53e6\u4e00\u9805\u982d\u5c0d\u982dDIO\u5927\u9f20\u7814\u7a76\u4e2d\uff0c\u5c07ASC39\uff085 mg\/kg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8207eloralintide\uff083 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u4e09\u5929\u4e00\u6b21\uff09\u9032\u884c\u4e86\u6bd4\u8f03\u3002\u958b\u59cb\u7d66\u85e5\u5f8c\u7684\u7b2c2\u5929\uff0c\u5169\u7a2e\u85e5\u7269\u5747\u958b\u59cb\u5f15\u8d77\u9ad4\u91cd\u4e0b\u964d\u3002\u5230\u7b2c7\u5929\u6642\uff0cASC39\u7d44\u548celoralintide\u7d44\u7684\u9ad4\u91cd\u8f03\u57fa\u7dda\u5206\u5225\u4e0b\u964d\u4e866.0%\uff08p <\/i>< 0.0001\uff09\u548c5.0%\uff08p<\/i> < 0.0001\uff09\uff0c\u800c\u5b89\u6170\u5291\u7d44\u7684\u9ad4\u91cd\u5247\u589e\u52a0\u4e860.6%\u3002<\/p>\n

\u95dc\u9375\u7d50\u8ad6<\/b><\/p>\n

\u9019\u4e9b\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cASC39\u662f\u4e00\u7a2e\u9ad8\u9078\u64c7\u6027\u4e14\u5f37\u6548\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u6709\u671b\u4f5c\u70ba\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5019\u9078\u85e5\u7269\u63a8\u9032\u958b\u767c\u3002<\/p>\n

2. \u53e3\u670d\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\u6fc0\u52d5\u5291\uff1aASC30<\/b><\/p>\n

ASC30\u662f\u4e00\u6b3e\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\u5b8c\u5168\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5176\u5316\u5b78\u9aa8\u67b6\u8207orforglipron\uff08OFG\uff09\u7684\u76f8\u4f3c\u3002\u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0cASC30\u7684\u6d3b\u6027\u7d04\u70baOFG\u76842\u81f33\u500d\u3002\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\uff0c1.5 mg\/kg\u5291\u91cf\u7684ASC30\u6240\u523a\u6fc0\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\u986f\u8457\u9ad8\u65bc6 mg\/kg\u5291\u91cf\u7684OFG\u6240\u523a\u6fc0\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\uff0c\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002\u5728\u4e00\u9805\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC30\u7684\u53e3\u670d\u66b4\u9732\u91cf\u7d04\u70baOFG\u76845\u500d\u3002\u5728\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\uff0cASC30\u57282\u6beb\u514b\u81f360\u6beb\u514b\u5291\u91cf\u7bc4\u570d\u5167\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\uff08dose-proportional\uff09\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff0c\u5cf0\u8c37\u6bd4\u4f4e\u65bc2:1\u3002\u5728\u4e00\u9805\u70ba\u671f4\u5468\u7684I\u671f\u7814\u7a76\u4e2d\uff0cASC30\u5728\u6240\u6709\u5291\u91cf\u7d44\uff0820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\uff09\u4e2d\u5747\u5c55\u73fe\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u6216\u7e3d\u81bd\u7d05\u7d20\uff08TBL\uff09\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002<\/p>\n

\u5728\u4e00\u9805II\u671f\u7814\u7a76\uff08n=125\uff09\u4e2d\uff0c\u6bcf\u65e5\u4e00\u6b21ASC30\u7247\u7684\u9802\u7dda\u7d50\u679c\u986f\u793a\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u5e73\u5747\u9ad4\u91cd\u4e0b\u964d\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\uff0c\u4e26\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u6e1b\u91cd\u5e73\u53f0\u671f\u3002\u5728\u7b2c13\u5468\u6642\uff0c20\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7dad\u6301\u5291\u91cf\u7684\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u9ad4\u91cd\u4e0b\u964d\u5206\u5225\u70ba5.4%\u30017.0%\u548c7.7%\u3002\u57fa\u7dda\u5e73\u5747\u9ad4\u91cd\u70ba107.3 kg\uff0c\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\u70ba38.6 kg\/m\u00b2\u3002\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u6bcf\u9031\u6ef4\u5b9a\uff08titrated weekly\uff09\u76f4\u81f3\u76ee\u6a19\u5291\u91cf\u7684ASC30\u7684\u5614\u5410\u767c\u751f\u7387\u7d04\u70ba\u6bcf\u9031\u6ef4\u5b9a\u7684OFG\u4e2d\u89c0\u5bdf\u5230\u7684\u5614\u5410\u767c\u751f\u7387\u7684\u4e00\u534a\u3002\u6bcf\u9031\u6ef4\u5b9a\u7684ASC30\u7684\u80c3\u8178\u9053\uff08GI\uff09\u8010\u53d7\u6027\u8207\u5df2\u516c\u4f48\u7684OFG\u5728III\u671fATTAIN-1\u7814\u7a76\u4e2d\u6bcf\u56db\u5468\u6ef4\u5b9a\uff08titrated every four weeks\uff09\u7684\u7d50\u679c\u76f8\u7576\u3002\u5728ASC30\u7684\u8a72\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u56b4\u91cd\u7a0b\u5ea6\u5747\u70ba1\u7d1a\uff08\u8f15\u5ea6\uff09\u548c2\u7d1a\uff08\u4e2d\u5ea6\uff09\uff0c\u71213\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u67093\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u7684\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u6709\u85e5\u7269\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u572820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7d44\u4e2d\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u7684\u505c\u85e5\u7387\u5206\u5225\u70ba7.3%\u30017.5%\u548c0.0%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba0.0%\u3002\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0cALT\u3001AST\u6216TBL\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002\u6b64\u5916\uff0c\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u751f\u547d\u9ad4\u5f81\u3001\u5fc3\u96fb\u5716\uff08\u5305\u62ecQTc\u9593\u671f\uff09\u548c\u9ad4\u683c\u6aa2\u67e5\u5747\u672a\u767c\u73fe\u7570\u5e38\u3002<\/p>\n

\u95dc\u9375\u7d50\u8ad6<\/b><\/p>\n

ASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u4e14\u8207OFG\u76f8\u6bd4\u5c55\u73fe\u51fa\u826f\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u7279\u5fb5\uff0c\u9019\u652f\u6301\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u3002\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u672b\u555f\u52d5\u3002\u8a72III\u671f\u81e8\u5e8a\u9805\u76ee\u5c07\u5305\u62ec\u5169\u9805\u70ba\u671f72\u5468\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\uff0c\u5728\u4f34\u6709\u6216\u4e0d\u4f34\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u80a5\u80d6\u6216\u8d85\u91cd\u53d7\u8a66\u8005\u4e2d\uff0c\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u3001\u7dad\u6301\u5291\u91cf\u70ba20\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7684ASC30\uff0c\u5291\u91cf\u6ef4\u5b9a\u671f\u6700\u9577\u70ba20\u5468\u3002<\/p>\n

3. \u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff1aASC37<\/b><\/p>\n

ASC37\u662f\u4e00\u6b3e\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u7684\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08POTENT\uff09\u958b\u767c\u800c\u6210\u7684\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u901a\u904e\u6291\u5236\u9176\u964d\u89e3\u4e26\u589e\u52a0\u80c3\u8178\u9053\u901a\u900f\u6027\uff0cPOTENT\u80fd\u5920\u5c07\u591a\u80bd\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5f9e<1%\u63d0\u9ad8\u81f3\u7d043%\u20135%\u3002\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\uff0c\u63a1\u7528\u6b4c\u79aePOTENT\u5236\u5291\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u662f\u63a1\u7528\u5176\u5546\u696d\u5316SNAC\uff08N-8-(2-\u7fa5\u57fa\u82ef\u7532\u9170\u80fa\u57fa)\u8f9b\u9178\u9209\uff09\u5236\u5291\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd\u76843\u500d\uff1b\u800c\u63a1\u7528\u6b4c\u79aePOTENT\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u7684\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u662f\u63a1\u7528SNAC\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u76849\u500d\u3002<\/p>\n

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\u95dc\u9375\u7d50\u8ad6<\/b><\/p>\n

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\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/b><\/p>\n

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\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

Peter Vozzo
ICR Healthcare
443-231-0505 (\u7f8e\u570b)
Peter.vozzo@icrhealthcare.com<\/a><\/span><\/p>\n

\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a
+86-181-0650-9129 (\u4e2d\u570b)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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weekly\uff09\u76f4\u81f3\u76ee\u6a19\u5291\u91cf\u7684ASC30\u7684\u5614\u5410\u767c\u751f\u7387\u7d04\u70ba\u6bcf\u9031\u6ef4\u5b9a\u7684OFG\u4e2d\u89c0\u5bdf\u5230\u7684\u5614\u5410\u767c\u751f\u7387\u7684\u4e00\u534a\u3002\u6bcf\u9031\u6ef4\u5b9a\u7684ASC30\u7684\u80c3\u8178\u9053\uff08GI\uff09\u8010\u53d7\u6027\u8207\u5df2\u516c\u4f48\u7684OFG\u5728III\u671fATTAIN-1\u7814\u7a76\u4e2d\u6bcf\u56db\u5468\u6ef4\u5b9a\uff08titrated every four weeks\uff09\u7684\u7d50\u679c\u76f8\u7576\u3002\u5728ASC30\u7684\u8a72\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u56b4\u91cd\u7a0b\u5ea6\u5747\u70ba1\u7d1a\uff08\u8f15\u5ea6\uff09\u548c2\u7d1a\uff08\u4e2d\u5ea6\uff09\uff0c\u71213\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u67093\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u7684\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u6709\u85e5\u7269\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u572820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7d44\u4e2d\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u7684\u505c\u85e5\u7387\u5206\u5225\u70ba7.3%\u30017.5%\u548c0.0%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba0.0%\u3002\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0cALT\u3001AST\u6216TBL\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002\u6b64\u5916\uff0c\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u751f\u547d\u9ad4\u5f81\u3001\u5fc3\u96fb\u5716\uff08\u5305\u62ecQTc\u9593\u671f\uff09\u548c\u9ad4\u683c\u6aa2\u67e5\u5747\u672a\u767c\u73fe\u7570\u5e38\u3002 \u95dc\u9375\u7d50\u8ad6 ASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u4e14\u8207OFG\u76f8\u6bd4\u5c55\u73fe\u51fa\u826f\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u7279\u5fb5\uff0c\u9019\u652f\u6301\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u3002\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u672b\u555f\u52d5\u3002\u8a72III\u671f\u81e8\u5e8a\u9805\u76ee\u5c07\u5305\u62ec\u5169\u9805\u70ba\u671f72\u5468\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\uff0c\u5728\u4f34\u6709\u6216\u4e0d\u4f34\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u80a5\u80d6\u6216\u8d85\u91cd\u53d7\u8a66\u8005\u4e2d\uff0c\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u3001\u7dad\u6301\u5291\u91cf\u70ba20\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7684ASC30\uff0c\u5291\u91cf\u6ef4\u5b9a\u671f\u6700\u9577\u70ba20\u5468\u3002 3. \u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff1aASC37 ASC37\u662f\u4e00\u6b3e\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u7684\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08POTENT\uff09\u958b\u767c\u800c\u6210\u7684\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u901a\u904e\u6291\u5236\u9176\u964d\u89e3\u4e26\u589e\u52a0\u80c3\u8178\u9053\u901a\u900f\u6027\uff0cPOTENT\u80fd\u5920\u5c07\u591a\u80bd\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5f9e<1%\u63d0\u9ad8\u81f3\u7d043%\u20135%\u3002\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\uff0c\u63a1\u7528\u6b4c\u79aePOTENT\u5236\u5291\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u662f\u63a1\u7528\u5176\u5546\u696d\u5316SNAC\uff08N-8-(2-\u7fa5\u57fa\u82ef\u7532\u9170\u80fa\u57fa)\u8f9b\u9178\u9209\uff09\u5236\u5291\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd\u76843\u500d\uff1b\u800c\u63a1\u7528\u6b4c\u79aePOTENT\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u7684\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u662f\u63a1\u7528SNAC\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u76849\u500d\u3002 \u5229\u7528POTENT\u5e73\u53f0\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC37\u53e3\u670d\u7247\u7684\u5e73\u5747\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u90544.2%\uff0c\u5206\u5225\u7d04\u70ba\u63a1\u7528SNAC\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u548cretatrutide\u768430\u500d\u548c60\u500d\u3002\u6b64\u5916\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC37\u53e3\u670d\u7247\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba56\u5c0f\u6642\uff0c\u652f\u6301\u6bcf\u65e5\u4e00\u6b21\u6216\u53ef\u80fd\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002 \u95dc\u9375\u7d50\u8ad6 ASC37\u662f\u4e00\u6b3e\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u5177\u6709\u826f\u597d\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u548c\u8f03\u9577\u7684\u534a\u8870\u671f\uff0c\u5728\u80a5\u80d6\u75c7\u548c\u5176\u5b83\u4ee3\u8b1d\u6027\u75be\u75c5\u9818\u57df\u5177\u6709\u5ee3\u95ca\u7684\u81e8\u5e8a\u958b\u767c\u524d\u666f\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u985e\u4f3celoralintide\u3001\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u548cASC30_39 FDC\uff0cASC30\uff08GLP-1RA\uff09\u8207ASC39\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u5236\u5291\uff08FDC\uff09\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=443080\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79aeASC30\u81e8\u5e8a\u6578\u64da\u8207ASC37\u3001ASC39\u4ee4\u4eba\u632f\u596e\u7684\u81e8\u5e8a\u524d\u7d50\u679c\u65bc\u7f8e\u570b\u7cd6\u5c3f\u75c5\u5354\u6703\uff08ADA\uff092026\u5e74\u5ea6\u79d1\u5b78\u6703\u8b70\u9f4a\u4eae\u76f8\uff0c\u592f\u5be6\u5dee\u7570\u5316\u80a5\u80d6\u7ba1\u7dda - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u9999\u6e2f2026\u5e746\u67088\u65e5 \/\u7f8e\u901a\u793e\/ -- 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\u6838\u5fc3\u6578\u64da 1. \u5f37\u6548\u53e3\u670d\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff1aASC39 \u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0cASC39\u5c0d\u4eba\u80f0\u6fb1\u7d201\u578b\u53d7\u9ad4\uff08hAMY1R\uff09\u7684\u9078\u64c7\u6027\u8207eloralintide\u7684\u76f8\u7576\uff0c\u4e14\u5176\u5c0d\u80f0\u6fb1\u7d20\u53d7\u9ad4\u7684\u89aa\u548c\u529b\uff08affinity\uff09\u986f\u8457\u9ad8\u65bc\u5c0d\u4eba\u964d\u9223\u7d20\u53d7\u9ad4\uff08hCTR\uff09\u7684\u89aa\u548c\u529b\u3002\u9019\u7a2e\u53d7\u9ad4\u9078\u64c7\u6027\u53ef\u80fd\u6709\u52a9\u65bc\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u7531\u964d\u9223\u7d20\u53d7\u9ad4\u4ecb\u5c0e\u7684\u4e2d\u6a1e\u4e0d\u826f\u53cd\u61c9\uff0c\u4f8b\u5982\u5641\u5fc3\u548c\u904e\u5ea6\u98df\u617e\u6291\u5236\u3002 \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u6a21\u578b\u4e2d\uff0cASC39\u4ee50.2 mg\/kg\u30011 mg\/kg\u548c5 mg\/kg\u7684\u5291\u91cf\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u3002\u7814\u7a76\u89c0\u5bdf\u5230\u9ad4\u91cd\u4e0b\u964d\u5448\u660e\u986f\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\uff08dose-dependent\uff09\u3002\u5728\u7b2c11\u5929\u6642\uff0c\u63a5\u53d75 mg\/kg ASC39\u6cbb\u7642\u7684\u52d5\u7269\u9ad4\u91cd\u8f03\u57fa\u7dda\u4e0b\u964d\u4e869.9%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u7684\u4e0b\u964d\u4e862.8%\uff08p < 0.01\uff09\u3002 \u5728\u53e6\u4e00\u9805\u982d\u5c0d\u982dDIO\u5927\u9f20\u7814\u7a76\u4e2d\uff0c\u5c07ASC39\uff085 mg\/kg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8207eloralintide\uff083 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ASC30\u662f\u4e00\u6b3e\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\u5b8c\u5168\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5176\u5316\u5b78\u9aa8\u67b6\u8207orforglipron\uff08OFG\uff09\u7684\u76f8\u4f3c\u3002\u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0cASC30\u7684\u6d3b\u6027\u7d04\u70baOFG\u76842\u81f33\u500d\u3002\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\uff0c1.5 mg\/kg\u5291\u91cf\u7684ASC30\u6240\u523a\u6fc0\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\u986f\u8457\u9ad8\u65bc6 mg\/kg\u5291\u91cf\u7684OFG\u6240\u523a\u6fc0\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\uff0c\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002\u5728\u4e00\u9805\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC30\u7684\u53e3\u670d\u66b4\u9732\u91cf\u7d04\u70baOFG\u76845\u500d\u3002\u5728\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\uff0cASC30\u57282\u6beb\u514b\u81f360\u6beb\u514b\u5291\u91cf\u7bc4\u570d\u5167\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\uff08dose-proportional\uff09\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff0c\u5cf0\u8c37\u6bd4\u4f4e\u65bc2:1\u3002\u5728\u4e00\u9805\u70ba\u671f4\u5468\u7684I\u671f\u7814\u7a76\u4e2d\uff0cASC30\u5728\u6240\u6709\u5291\u91cf\u7d44\uff0820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\uff09\u4e2d\u5747\u5c55\u73fe\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u6216\u7e3d\u81bd\u7d05\u7d20\uff08TBL\uff09\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002 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mg\\\/kg\u7684\u5291\u91cf\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u3002\u7814\u7a76\u89c0\u5bdf\u5230\u9ad4\u91cd\u4e0b\u964d\u5448\u660e\u986f\u7684\u5291\u91cf\u4f9d\u8cf4\u6027\uff08dose-dependent\uff09\u3002\u5728\u7b2c11\u5929\u6642\uff0c\u63a5\u53d75 mg\\\/kg ASC39\u6cbb\u7642\u7684\u52d5\u7269\u9ad4\u91cd\u8f03\u57fa\u7dda\u4e0b\u964d\u4e869.9%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u7684\u4e0b\u964d\u4e862.8%\uff08p < 0.01\uff09\u3002 \u5728\u53e6\u4e00\u9805\u982d\u5c0d\u982dDIO\u5927\u9f20\u7814\u7a76\u4e2d\uff0c\u5c07ASC39\uff085 mg\\\/kg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u8207eloralintide\uff083 nmol\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u4e09\u5929\u4e00\u6b21\uff09\u9032\u884c\u4e86\u6bd4\u8f03\u3002\u958b\u59cb\u7d66\u85e5\u5f8c\u7684\u7b2c2\u5929\uff0c\u5169\u7a2e\u85e5\u7269\u5747\u958b\u59cb\u5f15\u8d77\u9ad4\u91cd\u4e0b\u964d\u3002\u5230\u7b2c7\u5929\u6642\uff0cASC39\u7d44\u548celoralintide\u7d44\u7684\u9ad4\u91cd\u8f03\u57fa\u7dda\u5206\u5225\u4e0b\u964d\u4e866.0%\uff08p < 0.0001\uff09\u548c5.0%\uff08p < 0.0001\uff09\uff0c\u800c\u5b89\u6170\u5291\u7d44\u7684\u9ad4\u91cd\u5247\u589e\u52a0\u4e860.6%\u3002 \u95dc\u9375\u7d50\u8ad6 \u9019\u4e9b\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cASC39\u662f\u4e00\u7a2e\u9ad8\u9078\u64c7\u6027\u4e14\u5f37\u6548\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u6709\u671b\u4f5c\u70ba\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5019\u9078\u85e5\u7269\u63a8\u9032\u958b\u767c\u3002 2. \u53e3\u670d\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\u6fc0\u52d5\u5291\uff1aASC30 ASC30\u662f\u4e00\u6b3e\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\u53d7\u9ad4\uff08GLP-1R\uff09\u5b8c\u5168\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5176\u5316\u5b78\u9aa8\u67b6\u8207orforglipron\uff08OFG\uff09\u7684\u76f8\u4f3c\u3002\u9ad4\u5916\u7814\u7a76\u8868\u660e\uff0cASC30\u7684\u6d3b\u6027\u7d04\u70baOFG\u76842\u81f33\u500d\u3002\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\uff0c1.5 mg\\\/kg\u5291\u91cf\u7684ASC30\u6240\u523a\u6fc0\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\u986f\u8457\u9ad8\u65bc6 mg\\\/kg\u5291\u91cf\u7684OFG\u6240\u523a\u6fc0\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc\u91cf\uff0c\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002\u5728\u4e00\u9805\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC30\u7684\u53e3\u670d\u66b4\u9732\u91cf\u7d04\u70baOFG\u76845\u500d\u3002\u5728\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\uff0cASC30\u57282\u6beb\u514b\u81f360\u6beb\u514b\u5291\u91cf\u7bc4\u570d\u5167\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\uff08dose-proportional\uff09\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff0c\u5cf0\u8c37\u6bd4\u4f4e\u65bc2:1\u3002\u5728\u4e00\u9805\u70ba\u671f4\u5468\u7684I\u671f\u7814\u7a76\u4e2d\uff0cASC30\u5728\u6240\u6709\u5291\u91cf\u7d44\uff0820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\uff09\u4e2d\u5747\u5c55\u73fe\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u6216\u7e3d\u81bd\u7d05\u7d20\uff08TBL\uff09\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002 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weekly\uff09\u76f4\u81f3\u76ee\u6a19\u5291\u91cf\u7684ASC30\u7684\u5614\u5410\u767c\u751f\u7387\u7d04\u70ba\u6bcf\u9031\u6ef4\u5b9a\u7684OFG\u4e2d\u89c0\u5bdf\u5230\u7684\u5614\u5410\u767c\u751f\u7387\u7684\u4e00\u534a\u3002\u6bcf\u9031\u6ef4\u5b9a\u7684ASC30\u7684\u80c3\u8178\u9053\uff08GI\uff09\u8010\u53d7\u6027\u8207\u5df2\u516c\u4f48\u7684OFG\u5728III\u671fATTAIN-1\u7814\u7a76\u4e2d\u6bcf\u56db\u5468\u6ef4\u5b9a\uff08titrated every four weeks\uff09\u7684\u7d50\u679c\u76f8\u7576\u3002\u5728ASC30\u7684\u8a72\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u56b4\u91cd\u7a0b\u5ea6\u5747\u70ba1\u7d1a\uff08\u8f15\u5ea6\uff09\u548c2\u7d1a\uff08\u4e2d\u5ea6\uff09\uff0c\u71213\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u67093\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u7684\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u6709\u85e5\u7269\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u572820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7d44\u4e2d\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u7684\u505c\u85e5\u7387\u5206\u5225\u70ba7.3%\u30017.5%\u548c0.0%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba0.0%\u3002\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0cALT\u3001AST\u6216TBL\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002\u6b64\u5916\uff0c\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u751f\u547d\u9ad4\u5f81\u3001\u5fc3\u96fb\u5716\uff08\u5305\u62ecQTc\u9593\u671f\uff09\u548c\u9ad4\u683c\u6aa2\u67e5\u5747\u672a\u767c\u73fe\u7570\u5e38\u3002 \u95dc\u9375\u7d50\u8ad6 ASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u4e14\u8207OFG\u76f8\u6bd4\u5c55\u73fe\u51fa\u826f\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u7279\u5fb5\uff0c\u9019\u652f\u6301\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u3002\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u672b\u555f\u52d5\u3002\u8a72III\u671f\u81e8\u5e8a\u9805\u76ee\u5c07\u5305\u62ec\u5169\u9805\u70ba\u671f72\u5468\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\uff0c\u5728\u4f34\u6709\u6216\u4e0d\u4f34\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u80a5\u80d6\u6216\u8d85\u91cd\u53d7\u8a66\u8005\u4e2d\uff0c\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u3001\u7dad\u6301\u5291\u91cf\u70ba20\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7684ASC30\uff0c\u5291\u91cf\u6ef4\u5b9a\u671f\u6700\u9577\u70ba20\u5468\u3002 3. \u53e3\u670dGLP-1R\\\/GIPR\\\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff1aASC37 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\u5229\u7528POTENT\u5e73\u53f0\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC37\u53e3\u670d\u7247\u7684\u5e73\u5747\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u90544.2%\uff0c\u5206\u5225\u7d04\u70ba\u63a1\u7528SNAC\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u548cretatrutide\u768430\u500d\u548c60\u500d\u3002\u6b64\u5916\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC37\u53e3\u670d\u7247\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba56\u5c0f\u6642\uff0c\u652f\u6301\u6bcf\u65e5\u4e00\u6b21\u6216\u53ef\u80fd\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002 \u95dc\u9375\u7d50\u8ad6 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weeks\uff09\u7684\u7d50\u679c\u76f8\u7576\u3002\u5728ASC30\u7684\u8a72\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u56b4\u91cd\u7a0b\u5ea6\u5747\u70ba1\u7d1a\uff08\u8f15\u5ea6\uff09\u548c2\u7d1a\uff08\u4e2d\u5ea6\uff09\uff0c\u71213\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u67093\u7d1a\uff08\u91cd\u5ea6\uff09\u6216\u4ee5\u4e0a\u7684\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u3002\u6c92\u6709\u85e5\u7269\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u572820\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7d44\u4e2d\uff0c\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u7684\u505c\u85e5\u7387\u5206\u5225\u70ba7.3%\u30017.5%\u548c0.0%\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba0.0%\u3002\u672a\u89c0\u5bdf\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\uff0cALT\u3001AST\u6216TBL\u6c34\u5e73\u4e5f\u672a\u6709\u5347\u9ad8\u3002\u6b64\u5916\uff0c\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u751f\u547d\u9ad4\u5f81\u3001\u5fc3\u96fb\u5716\uff08\u5305\u62ecQTc\u9593\u671f\uff09\u548c\u9ad4\u683c\u6aa2\u67e5\u5747\u672a\u767c\u73fe\u7570\u5e38\u3002 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ASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u4e14\u8207OFG\u76f8\u6bd4\u5c55\u73fe\u51fa\u826f\u597d\u7684\u80c3\u8178\u9053\u8010\u53d7\u6027\u7279\u5fb5\uff0c\u9019\u652f\u6301\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u3002\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5168\u7403III\u671f\u81e8\u5e8a\u8a66\u9a57\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u672b\u555f\u52d5\u3002\u8a72III\u671f\u81e8\u5e8a\u9805\u76ee\u5c07\u5305\u62ec\u5169\u9805\u70ba\u671f72\u5468\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7814\u7a76\uff0c\u5728\u4f34\u6709\u6216\u4e0d\u4f34\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u80a5\u80d6\u6216\u8d85\u91cd\u53d7\u8a66\u8005\u4e2d\uff0c\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u3001\u7dad\u6301\u5291\u91cf\u70ba20\u6beb\u514b\u300140\u6beb\u514b\u548c60\u6beb\u514b\u7684ASC30\uff0c\u5291\u91cf\u6ef4\u5b9a\u671f\u6700\u9577\u70ba20\u5468\u3002 3. \u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff1aASC37 ASC37\u662f\u4e00\u6b3e\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u7684\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08POTENT\uff09\u958b\u767c\u800c\u6210\u7684\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u901a\u904e\u6291\u5236\u9176\u964d\u89e3\u4e26\u589e\u52a0\u80c3\u8178\u9053\u901a\u900f\u6027\uff0cPOTENT\u80fd\u5920\u5c07\u591a\u80bd\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5f9e<1%\u63d0\u9ad8\u81f3\u7d043%\u20135%\u3002\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\uff0c\u63a1\u7528\u6b4c\u79aePOTENT\u5236\u5291\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u662f\u63a1\u7528\u5176\u5546\u696d\u5316SNAC\uff08N-8-(2-\u7fa5\u57fa\u82ef\u7532\u9170\u80fa\u57fa)\u8f9b\u9178\u9209\uff09\u5236\u5291\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd\u76843\u500d\uff1b\u800c\u63a1\u7528\u6b4c\u79aePOTENT\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u7684\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u662f\u63a1\u7528SNAC\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u76849\u500d\u3002 \u5229\u7528POTENT\u5e73\u53f0\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC37\u53e3\u670d\u7247\u7684\u5e73\u5747\u7d55\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u90544.2%\uff0c\u5206\u5225\u7d04\u70ba\u63a1\u7528SNAC\u5236\u5291\u7684\u66ff\u723e\u6cca\u80bd\u548cretatrutide\u768430\u500d\u548c60\u500d\u3002\u6b64\u5916\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC37\u53e3\u670d\u7247\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba56\u5c0f\u6642\uff0c\u652f\u6301\u6bcf\u65e5\u4e00\u6b21\u6216\u53ef\u80fd\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002 \u95dc\u9375\u7d50\u8ad6 ASC37\u662f\u4e00\u6b3e\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u5177\u6709\u826f\u597d\u7684\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u548c\u8f03\u9577\u7684\u534a\u8870\u671f\uff0c\u5728\u80a5\u80d6\u75c7\u548c\u5176\u5b83\u4ee3\u8b1d\u6027\u75be\u75c5\u9818\u57df\u5177\u6709\u5ee3\u95ca\u7684\u81e8\u5e8a\u958b\u767c\u524d\u666f\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement 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