{"id":441261,"date":"2026-06-02T14:55:00","date_gmt":"2026-06-02T06:55:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=441261"},"modified":"2026-06-02T14:55:00","modified_gmt":"2026-06-02T06:55:00","slug":"%e6%99%b6%e6%b3%b0%e7%a7%91%e6%8a%80%e8%b3%a6%e8%83%bd%e5%b8%8c%e6%a0%bc%e7%94%9f%e7%a7%91%e5%86%8d%e7%8d%b2ind%ef%bc%9a%e5%bc%b7%e6%b4%bb%e6%80%a7-pan-tead%e6%8a%91%e5%88%b6%e5%8a%91sigx2649%e8%87%a8","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=441261","title":{"rendered":"\u6676\u6cf0\u79d1\u6280\u8ce6\u80fd\u5e0c\u683c\u751f\u79d1\u518d\u7372IND\uff1a\u5f37\u6d3b\u6027 pan-TEAD\u6291\u5236\u5291SIGX2649\u81e8\u5e8a\u6f5b\u529b\u51f8\u986f\uff0cAI+\u985e\u5668\u5b98\u6a21\u5f0f\u6301\u7e8c\u9a57\u8b49"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td> <\/a> <br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u6b64\u6b21 SIGX2649 \u63d0\u524d IND \u7372\u6279\uff0c\u5145\u5206\u9ad4\u73fe\u4e86\u8a72\u7ba1\u7dda\u7684\u81e8\u5e8a\u6025\u9700\u6027\u3002\u5176\u6838\u5fc3\u81e8\u5e8a\u524d\u7814\u7a76\u6578\u64da\u5c55\u73fe\u51fa\u512a\u7570\u7684\u6210\u85e5\u6027\u3001\u5b89\u5168\u6027\u8207\u5dee\u7570\u5316\u7684\u81e8\u5e8a\u50f9\u503c\u3002\u540c\u6642\uff0c\u5ee3\u6771\u7701\u4eba\u6c11\u91ab\u9662\u9996\u5e2d\u5c08\u5bb6\u3001\u4e2d\u570b\u80ba\u764c\u7cbe\u6e96\u6cbb\u7642\u9818\u8ecd\u4eba\u7269\u5433\u4e00\u9f8d\u6559\u6388\u5c07\u6b63\u5f0f\u64d4\u4efb SIGX2649 \u7684 I \u671f\u81e8\u5e8a\uff0c\u548c SIGX1094 \u806f\u5408 KRAS-G12C \u6291\u5236\u5291 I\/II \u671f\u81e8\u5e8a\u7684\u9996\u5e2d\u7814\u7a76\u8005\uff08Leading PI\uff09\uff0c\u52a0\u901f\u63a8\u9032\u5169\u5927\u6838\u5fc3\u7ba1\u7dda\u7684\u5168\u7403\u958b\u767c\u3002<\/p>\n<p>\u6676\u6cf0\u79d1\u6280\u8207\u5e0c\u683c\u751f\u79d1\u591a\u500b\u5728\u7814\u7ba1\u7dda\u7684\u9023\u7e8c\u6210\u529f\uff0c\u6709\u529b\u5370\u8b49\u4e86\u5176\u5e95\u5c64\u7814\u767c\u5e73\u53f0 \u300c\u5f9e\u7b97\u6cd5\u5230\u81e8\u5e8a\u300d \u7684\u5feb\u901f\u8f49\u5316\u80fd\u529b\uff0c\u4ee5\u53ca \u300cAI+\u985e\u5668\u5b98\u300d \u6a21\u5f0f\u5728\u653b\u5805\u9ad8\u50f9\u503c\u3001\u5275\u65b0\u9776\u9ede\u85e5\u7269\u958b\u767c\u4e2d\u7684\u5de8\u5927\u6f5b\u529b\u3002\u6839\u64da\u96d9\u65b9\u5354\u8b70\uff0c\u6676\u6cf0\u79d1\u6280\u6709\u6b0a\u7372\u5f97 SIGX2649 \u6700\u9ad8\u9054\u5169\u4f4d\u6578\u6bd4\u4f8b\u7684\u5546\u696d\u5316\u6536\u76ca\u5206\u6210\u3002<\/p>\n<p>TEAD \u86cb\u767d\u662f Hippo \u4fe1\u865f\u901a\u8def\u7684\u6838\u5fc3\u7bc0\u9ede\uff0c\u8a72\u901a\u8def\u8207 P53\u3001RAS \u7b49\u4e26\u5217\u70ba\u6838\u5fc3\u816b\u7624\u9a45\u52d5\u901a\u8def\uff0c\u5728\u9593\u76ae\u7624\u3001\u809d\u764c\u3001\u80ba\u764c\u7b49\u5be6\u9ad4\u7624\u6cbb\u7642\u4e2d\u5177\u6709\u5ee3\u95ca\u524d\u666f\uff0c\u4f46\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u85e5\u7269\u3002TEAD \u86cb\u767d\u5bb6\u65cf\u5b58\u5728\u56db\u7a2e\u529f\u80fd\u8207\u8868\u9054\u6a21\u5f0f\u5404\u7570\u7684\u4e9e\u578b\uff0c\u5176\u6291\u5236\u5291\u9700\u5728\u5f37\u6548\u6291\u5236\u5404\u4e9e\u578b\u8207\u5b89\u5168\u6027\u4e4b\u9593\u53d6\u5f97\u5e73\u8861\uff0c\u6975\u5177\u6311\u6230\u6027\u3002\u76ee\u524d\u5168\u7403\u7bc4\u570d\u5167\u5c1a\u7121 TEAD \u6291\u5236\u5291\u7372\u6279\u4e0a\u5e02\uff0c\u6700\u5feb\u5728\u7814\u7522\u54c1\u4ea6\u8655\u65bc I \u671f\u81e8\u5e8a\u968e\u6bb5\u3002<\/p>\n<p>SIGX2649 \u662f\u6676\u6cf0\u79d1\u6280\u8207\u5e0c\u683c\u751f\u79d1\u57fa\u65bc \u300cAI+\u985e\u5668\u5b98\u300d \u6a21\u5f0f\u5408\u4f5c\u7814\u767c\u7684\u6cdb TEAD\uff08TEAD 1-4\uff09\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411 TEAD \u5bb6\u65cf\u5168\u90e8 4 \u7a2e\u4e9e\u578b\uff0c\u5c55\u73fe\u51fa\u5ee3\u95ca\u7684\u81e8\u5e8a\u958b\u767c\u524d\u666f\u3002\u5176\u96d9\u91cd\u4f5c\u7528\u6a5f\u5236\uff0c\u5728\u6291\u5236 TEAD \u68d5\u6ada\u9170\u5316\u7684\u540c\u6642\u589e\u5f37 VGLL4 \u8207 TEAD \u7684\u7d50\u5408\uff0c\u80fd\u9032\u4e00\u6b65\u653e\u5927\u8a72\u85e5\u5c0d YAP\/TEAD \u529f\u80fd\u7684\u6291\u5236\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\uff0cSIGX2649 \u5728\u9ad4\u5916\u591a\u7a2e\u816b\u7624\u6a21\u578b\uff08\u5305\u62ec\u809d\u764c\u985e\u5668\u5b98\u3001\u9593\u76ae\u7624\u7b49\uff09\u4e2d\u8868\u73fe\u51fa\u512a\u7570\u7684\u6297\u589e\u6b96\u6d3b\u6027\uff0c\u9ad4\u5167\u6291\u7624\u6548\u679c\u986f\u8457\uff0c\u85e5\u4ee3\u52d5\u529b\u5b78\u826f\u597d\uff0c\u4e14\u814e\u9776\u5411\u6bd2\u6027\u4f4e\u65bc\u540c\u985e\u5728\u7814\u85e5\u7269\uff0c\u64c1\u6709\u5dee\u7570\u5316\u7684\u81e8\u5e8a\u512a\u52e2\u8207\u540c\u985e\u6700\u4f73\uff08Best-in-class)\u7684\u6cbb\u7642\u6f5b\u529b\u3002<\/p>\n<p>SIGX2649 \u6709\u671b\u5728\u5c0f\u7d30\u80de\u80ba\u764c\uff0c\u9593\u76ae\u7624\u4ee5\u53ca\u809d\u764c\u7b49\u5b58\u5728\u986f\u8457\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u7684\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u767c\u63ee\u5de8\u5927\u7684\u7642\u6548\u6f5b\u80fd\u3002\u6b64\u5916\uff0c\u5b83\u8207 RAS \u901a\u8def\u6291\u5236\u5291\u806f\u7528\uff0c\u5728 KRAS \u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5982\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4ee5\u53ca\u8178\u764c\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u5354\u540c\u6548\u61c9\u3002\u57fa\u65bc\u4e0a\u8ff0\u512a\u7570\u6578\u64da\uff0cSIGX2649 \u7684\u6838\u5fc3\u81e8\u5e8a\u524d\u7814\u7a76\u5df2\u5165\u9078\u5168\u7403\u6700\u5177\u6b0a\u5a01\u548c\u5f71\u97ff\u529b\u7684\u764c\u75c7\u7814\u7a76\u5b78\u8853\u76db\u6703\u2014\u2014\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff092026\u5e74\u5e74\u6703\u5831\u544a\u3002<\/p>\n<p>\u5728 SIGX2649 \u7684\u767c\u73fe\u904e\u7a0b\u4e2d\uff0c\u6676\u6cf0\u79d1\u6280\u57fa\u65bc\u91cf\u5b50\u7269\u7406\u3001AI \u8207\u81ea\u52d5\u5316\u5408\u6210\u5e73\u53f0\uff0c\u5be6\u73fe\u4e86\u865b\u64ec\u7be9\u9078\u8207\u7269\u7406\u5408\u6210\u7684\u5feb\u901f\u9589\u74b0\u3002\u6676\u6cf0\u79d1\u6280\u9996\u5148\u901a\u904e AI 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\u8fed\u4ee3\u512a\u5316\uff0c\u6700\u7d42\u901a\u904e\u9ad4\u5167\u85e5\u6548\u8207\u5b89\u5168\u6027\u9a57\u8b49\uff0c\u78ba\u5b9a SIGX2649 \u70ba\u81e8\u5e8a\u524d\u5019\u9078\u5316\u5408\u7269\uff08PCC\uff09\u3002 \u6b64\u524d\uff0c\u6676\u6cf0\u79d1\u6280\u8207\u5e0c\u683c\u751f\u79d1\u5408\u4f5c\u7814\u767c\u7684\u5168\u7403\u9996\u6b3e \u300cAI+\u985e\u5668\u5b98\u300d \u65b0\u85e5\uff0c\u4e5f\u662f\u9996\u6b3e\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684 FAK\/SRC \u96d9\u9776\u9ede\u6291\u5236\u5291 SIGX1094\uff0c\u5df2\u7372\u7f8e\u570b FDA \u6388\u4e88\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\u8207\u5feb\u901f\u901a\u9053\u8cc7\u683c\uff0c\u4e26\u7372\u5f97 2025 \u5e74\u84cb\u502b\u734e\uff08Prix Galien USA\uff09\u63d0\u540d\uff0c\u76ee\u524d\u6b63\u5728\u5317\u4eac\u5927\u5b78\u816b\u7624\u91ab\u9662\u958b\u5c55\u7030\u6f2b\u6027\u80c3\u764c I \u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u4e26\u5373\u5c07\u555f\u52d5 II \u671f\u3002\u8a72\u5206\u5b50\u5f9e\u767c\u73fe\u5230 IND 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Limited\u300d\uff0c\u80a1\u4efd\u7c21\u7a31\uff1a\u6676\u6cf0\u63a7\u80a1\uff0cXTALPI\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2228.HK\uff09\u7531\u4e09\u4f4d\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u7684\u7269\u7406\u5b78\u5bb6\u65bc 2015 \u5e74\u5275\u7acb\uff0c\u662f\u4e00\u500b\u57fa\u65bc\u91cf\u5b50\u7269\u7406\u3001\u4ee5\u4eba\u5de5\u667a\u80fd\u8ce6\u80fd\u548c\u6a5f\u5668\u4eba\u9a45\u52d5\u7684\u5275\u65b0\u578b\u7814\u767c\u5e73\u53f0\u3002\u516c\u53f8\u63a1\u7528\u57fa\u65bc\u91cf\u5b50\u7269\u7406\u7684\u7b2c\u4e00\u6027\u539f\u7406\u8a08\u7b97\u3001\u4eba\u5de5\u667a\u80fd\u3001\u9ad8\u6027\u80fd\u96f2\u8a08\u7b97\u4ee5\u53ca\u53ef\u64f4\u5c55\u53ca\u6a19\u6e96\u5316\u7684\u6a5f\u5668\u4eba\u81ea\u52d5\u5316\u76f8\u7d50\u5408\u7684\u65b9\u5f0f\uff0c\u70ba\u88fd\u85e5\u53ca\u6750\u6599\u79d1\u5b78\uff08\u5305\u62ec\u8fb2\u696d\u6280\u8853\u3001\u80fd\u6e90\u53ca\u65b0\u578b\u5316\u5b78\u54c1\u4ee5\u53ca\u5316\u599d\u54c1\uff09\u7b49\u7522\u696d\u7684\u5168\u7403\u548c\u570b\u5167\u516c\u53f8\u63d0\u4f9b\u85e5\u7269\u53ca\u6750\u6599\u79d1\u5b78\u7814\u767c\u89e3\u6c7a\u65b9\u6848\u53ca\u670d\u52d9\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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Signet \u7684\u97f3\u8b6f\uff0c\u800c\u4e14\u79c9\u627f \u300c\u5e0c\u5180\u6eff\u61f7\uff0c\u683c\u7269\u81f4\u77e5\u300d \u7684\u9858\u666f\uff0c\u516c\u53f8\u5229\u7528\u63a5\u8fd1\u75c5\u4eba\u57fa\u56e0\u7d44\u5b78\u7279\u5fb5\u7684\u985e\u5668\u5b98\u75be\u75c5\u6a21\u578b\u5728\u85e5\u6548\u8a55\u50f9\u53ca\u65b0\u9776\u9ede\u767c\u73fe\u4e2d\u7684\u95dc\u9375\u4f5c\u7528\uff0c\u7d50\u5408 AI \u4eba\u5de5\u667a\u80fd\u7be9\u9078\u3001\u5408\u6210\u548c\u512a\u5316\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u958b\u767c first-in-class \u5275\u65b0\u9776\u5411\u85e5\u30022025 \u5e74 4 \u6708\uff0c\u7f8e\u570b FDA \u6b63\u5f0f\u767c\u4f48\u8072\u660e\uff0c\u660e\u78ba\u652f\u6301\u985e\u5668\u5b98\u548c AI \u6280\u8853\u9010\u6b65\u66ff\u4ee3\u50b3\u7d71\u52d5\u7269\u5be6\u9a57\uff0c\u5145\u5206\u9a57\u8b49\u4e86\u5176\u6280\u8853\u4f48\u5c40\u7684\u524d\u77bb\u6027\u8207\u79d1\u5b78\u6027\u3002 \u95dc\u65bc\u6676\u6cf0\u79d1\u6280 \u6676\u6cf0\u79d1\u6280\uff08\u300cXtalPi Holdings Limited\u300d\uff0c\u80a1\u4efd\u7c21\u7a31\uff1a\u6676\u6cf0\u63a7\u80a1\uff0cXTALPI\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2228.HK\uff09\u7531\u4e09\u4f4d\u9ebb\u7701\u7406\u5de5\u5b78\u9662\u7684\u7269\u7406\u5b78\u5bb6\u65bc 2015 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