{"id":440726,"date":"2026-06-01T09:41:00","date_gmt":"2026-06-01T01:41:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=440726"},"modified":"2026-06-01T09:41:00","modified_gmt":"2026-06-01T01:41:00","slug":"%e3%80%90%e7%9b%b4%e6%93%8aasco-2026%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5mdm2-p53%e6%8a%91%e5%88%b6%e5%8a%91apg-115%e5%85%92%e7%ab%a5%e5%af%a6%e9%ab%94%e7%98%a4%e6%95%b8%e6%93%9a%e9%a6%96","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=440726","title":{"rendered":"\u3010\u76f4\u64caASCO 2026\u3011\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291APG-115\u5152\u7ae5\u5be6\u9ad4\u7624\u6578\u64da\u9996\u767c\uff0c\u300c\u661f\u5149\u8a08\u5283\u300d\u54c1\u7a2e\u6f5b\u529b\u521d\u986f"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2026\u5e746\u67081\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c62\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u5feb\u901f\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u9996\u6b21\u5c55\u793a\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eMDM2-p53 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id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u4e5d\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u4e09\u500b\u91cd\u9ede\u54c1\u7a2e\u5171\u6709\u516d\u9805\u7814\u7a76\u5165\u9078\uff0c\u5176\u4e2d\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a\u3002<\/p>\n<p>\u6b64\u6b21\u5feb\u901f\u53e3\u982d\u5831\u544a\u7684\u7814\u7a76\u9032\u5c55\u521d\u6b65\u5c55\u73fe\u4e86APG-115\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u3002\u6578\u64da\u986f\u793a\uff1aAPG-115\u55ae\u85e5\u6cbb\u7642\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u521d\u986f\u7642\u6548\uff0c1\u4f8b\u5152\u7ae5\u60a3\u8005\u7372\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\uff1b\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5c55\u73fe\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\uff0c17\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba23.5%\uff0c\u5176\u4e2d1\u4f8b\u5c24\u6587\u8089\u7624\u7372\u5f97\u5b8c\u5168\u7de9\u89e3\uff0c3\u4f8b\u7372\u5f97\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff1b\u800c\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cAPG-115\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5728\u5152\u7ae5\u5be6\u9ad4\u7624\u4eba\u7fa4\u4e2d\u5b89\u5168\u53ef\u63a7\u3002<\/p>\n<p>APG-115\u662f\u4e9e\u76db\u91ab\u85e5\u81ea\u4e3b\u7814\u767c\u7684\u53e3\u670d\u3001\u9ad8\u9078\u64c7\u6027MDM2-p53\u6291\u5236\u5291\uff0c\u70ba\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684\u540c\u985e\u9776\u9ede\u54c1\u7a2e\uff0c\u5177\u6709First-in-class\u6f5b\u529b\u3002\u8a72\u54c1\u7a2e\u901a\u904e\u963b\u65b7MDM2-p53\u76f8\u4e92\u4f5c\u7528\uff0c\u6062\u5fa9p53\u7684\u816b\u7624\u6291\u5236\u6d3b\u6027\uff0c\u5f9e\u800c\u8a98\u5c0e\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u3002\u65e5\u524d\uff0cAPG-115\u5df2\u88ab\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6b63\u5f0f\u7d0d\u5165<span>\u300c<\/span>\u5152\u7ae5\u6297\u816b\u7624\u85e5\u7269\u7814\u767c\u9f13\u52f5\u8a66\u9ede\u8a08\u5283<span>\u300d<\/span>\uff08\u661f\u5149\u8a08\u5283\uff09\u8a66\u9ede\u9805\u76ee\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u3001\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u7b49\u5152\u7ae5\u5be6\u9ad4\u7624\u3002<\/p>\n<p><b>\u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\u5f35\u7ffc\u9ddf\u6559\u6388<\/b>\u8868\u793a\uff1a<span>\u300c<\/span>\u5fa9\u767c\/\u96e3\u6cbb\u6027\u5152\u7ae5\u8089\u7624\u9810\u5f8c\u6975\u5dee\uff0c\u81e8\u5e8a\u9700\u6c42\u8feb\u5207\u3002\u6b64\u6b21\u5728ASCO \u5c55\u793a\u7684\u6578\u64da\u8b49\u5be6\uff0cAPG-115 \u55ae\u85e5\u53ca\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5c55\u73fe\u51fa\u826f\u597d\u8010\u53d7\u6027\u8207\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5c24\u5176\u662fCR \u75c5\u4f8b\u4ee4\u4eba\u9f13\u821e\u3002\u4f5c\u70ba\u661f\u5149\u8a08\u5283\u91cd\u9ede\u54c1\u7a2e\uff0c\u5176First-in-class\u6f5b\u529b\u6709\u671b\u586b\u88dc\u6cbb\u7642\u7a7a\u767d\uff0c\u70ba\u60a3\u5152\u5e36\u4f86\u9577\u671f\u751f\u5b58\u65b0\u5e0c\u671b\u3002<span>\u300d<\/span><\/p>\n<p><b>\u8a72\u9805\u7814\u7a76\u7684\u7814\u7a76\u8005\u3001\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u540c\u4ec1\u91ab\u9662\u5152\u79d1\u5f35\u8abc\u6559\u6388\u8868\u793a<\/b>\uff1a<span>\u300c<\/span>\u5152\u7ae5\u5be6\u9ad4\u7624\u5c24\u5176\u662f\u665a\u671f\u8edf\u7d44\u7e54\u8089\u7624\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u6b64\u6b21 APG-115 \u806f\u5408\u65b9\u6848\u4ea4\u51fa\u7684\u81e8\u5e8a\u6578\u64da\u610f\u7fa9\u91cd\u5927\u3002\u8a72\u51cb\u4ea1\u901a\u8def\u9776\u5411\u85e5\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\u8868\u73fe\u53ef\u89c0\uff0c\u5145\u5206\u5370\u8b49\u4e86\u96d9\u9776\u9ede\u806f\u5408\u6cbb\u7642\u5728\u5152\u7ae5\u96e3\u6cbb\u6027\u816b\u7624\u4e2d\u7684\u61c9\u7528\u50f9\u503c\uff0c\u4e5f\u70ba\u5f8c\u7e8c\u5152\u7ae5\u816b\u7624\u7cbe\u51c6\u65b0\u85e5\u7814\u767c\u6307\u660e\u4e86\u512a\u8cea\u65b9\u5411\u3002<span>\u300d<\/span><\/p>\n<p><b>\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a<\/b><span>\u300c<\/span>\u5152\u7ae5\u5be6\u9ad4\u7624\u9818\u57df\u9577\u671f\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u6b64\u6b21\u5728ASCO\u5c55\u793a\u7684\u7814\u7a76\u70baAPG-115\u6cbb\u7642\u5152\u7ae5\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u6578\u64da\u9996\u6b21\u4eae\u76f8\uff0c\u521d\u6b65\u5c55\u73fe\u7684\u7642\u6548\u548c\u8010\u53d7\u6027\u4ee4\u4eba\u9f13\u821e\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-115\u6b64\u524d\u5df2\u7372CDE\u7d0d\u5165\u300e\u661f\u5149\u8a08\u5283\u300f\uff0c\u64ec\u958b\u767c\u7528\u65bc\u591a\u7a2e\u5152\u7ae5\u5be6\u9ad4\u7624\u3002\u6b64\u6b21\u5c55\u793a\u7684\u6578\u64da\u70ba\u9019\u4e00\u65b9\u5411\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u5faa\u8b49\u652f\u6301\u3002\u6211\u5011\u5c07\u52a0\u5feb\u63a8\u9032\u76f8\u95dc\u7814\u7a76\uff0c\u671f\u5f85\u65e9\u65e5\u70ba\u9019\u4e9b\u4e9f\u9700\u65b0\u7642\u6cd5\u7684\u5152\u7ae5\u60a3\u8005\u5e36\u4f86\u5e0c\u671b\u3002<span>\u300d<\/span><\/p>\n<p>\u6b64\u9805\u7814\u7a76\u57282026 ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n<p><b>Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)<br \/><\/b><b>Alrizomadlin<\/b><b>\uff08<\/b><b>APG-115<\/b><b>\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08<\/b><b>APG-2575<\/b><b>\uff09\u6cbb\u7642\u5fa9\u767c<\/b><b>\/<\/b><b>\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08<\/b><b>RMS<\/b><b>\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08<\/b><b>STSs<\/b><b>\uff09\u5152\u7ae5\u60a3\u8005<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>10012<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u5feb\u901f\u53e3\u982d\u5831\u544a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09<br 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content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u64caASCO 2026\u3011\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291APG-115\u5152\u7ae5\u5be6\u9ad4\u7624\u6578\u64da\u9996\u767c\uff0c\u300c\u661f\u5149\u8a08\u5283\u300d\u54c1\u7a2e\u6f5b\u529b\u521d\u986f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e746\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c62\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u5feb\u901f\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u9996\u6b21\u5c55\u793a\u4e86\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eMDM2-p53 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\u6b64\u6b21\u5feb\u901f\u53e3\u982d\u5831\u544a\u7684\u7814\u7a76\u9032\u5c55\u521d\u6b65\u5c55\u73fe\u4e86APG-115\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u6297\u816b\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u3002\u6578\u64da\u986f\u793a\uff1aAPG-115\u55ae\u85e5\u6cbb\u7642\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u521d\u986f\u7642\u6548\uff0c1\u4f8b\u5152\u7ae5\u60a3\u8005\u7372\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\uff1b\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5c55\u73fe\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\uff0c17\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba23.5%\uff0c\u5176\u4e2d1\u4f8b\u5c24\u6587\u8089\u7624\u7372\u5f97\u5b8c\u5168\u7de9\u89e3\uff0c3\u4f8b\u7372\u5f97\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff1b\u800c\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cAPG-115\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5728\u5152\u7ae5\u5be6\u9ad4\u7624\u4eba\u7fa4\u4e2d\u5b89\u5168\u53ef\u63a7\u3002 APG-115\u662f\u4e9e\u76db\u91ab\u85e5\u81ea\u4e3b\u7814\u767c\u7684\u53e3\u670d\u3001\u9ad8\u9078\u64c7\u6027MDM2-p53\u6291\u5236\u5291\uff0c\u70ba\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684\u540c\u985e\u9776\u9ede\u54c1\u7a2e\uff0c\u5177\u6709First-in-class\u6f5b\u529b\u3002\u8a72\u54c1\u7a2e\u901a\u904e\u963b\u65b7MDM2-p53\u76f8\u4e92\u4f5c\u7528\uff0c\u6062\u5fa9p53\u7684\u816b\u7624\u6291\u5236\u6d3b\u6027\uff0c\u5f9e\u800c\u8a98\u5c0e\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u3002\u65e5\u524d\uff0cAPG-115\u5df2\u88ab\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6b63\u5f0f\u7d0d\u5165\u300c\u5152\u7ae5\u6297\u816b\u7624\u85e5\u7269\u7814\u767c\u9f13\u52f5\u8a66\u9ede\u8a08\u5283\u300d\uff08\u661f\u5149\u8a08\u5283\uff09\u8a66\u9ede\u9805\u76ee\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u3001\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u7b49\u5152\u7ae5\u5be6\u9ad4\u7624\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\u5f35\u7ffc\u9ddf\u6559\u6388\u8868\u793a\uff1a\u300c\u5fa9\u767c\/\u96e3\u6cbb\u6027\u5152\u7ae5\u8089\u7624\u9810\u5f8c\u6975\u5dee\uff0c\u81e8\u5e8a\u9700\u6c42\u8feb\u5207\u3002\u6b64\u6b21\u5728ASCO \u5c55\u793a\u7684\u6578\u64da\u8b49\u5be6\uff0cAPG-115 \u55ae\u85e5\u53ca\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5c55\u73fe\u51fa\u826f\u597d\u8010\u53d7\u6027\u8207\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5c24\u5176\u662fCR \u75c5\u4f8b\u4ee4\u4eba\u9f13\u821e\u3002\u4f5c\u70ba\u661f\u5149\u8a08\u5283\u91cd\u9ede\u54c1\u7a2e\uff0c\u5176First-in-class\u6f5b\u529b\u6709\u671b\u586b\u88dc\u6cbb\u7642\u7a7a\u767d\uff0c\u70ba\u60a3\u5152\u5e36\u4f86\u9577\u671f\u751f\u5b58\u65b0\u5e0c\u671b\u3002\u300d \u8a72\u9805\u7814\u7a76\u7684\u7814\u7a76\u8005\u3001\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u540c\u4ec1\u91ab\u9662\u5152\u79d1\u5f35\u8abc\u6559\u6388\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u5c24\u5176\u662f\u665a\u671f\u8edf\u7d44\u7e54\u8089\u7624\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u6b64\u6b21 APG-115 \u806f\u5408\u65b9\u6848\u4ea4\u51fa\u7684\u81e8\u5e8a\u6578\u64da\u610f\u7fa9\u91cd\u5927\u3002\u8a72\u51cb\u4ea1\u901a\u8def\u9776\u5411\u85e5\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\u8868\u73fe\u53ef\u89c0\uff0c\u5145\u5206\u5370\u8b49\u4e86\u96d9\u9776\u9ede\u806f\u5408\u6cbb\u7642\u5728\u5152\u7ae5\u96e3\u6cbb\u6027\u816b\u7624\u4e2d\u7684\u61c9\u7528\u50f9\u503c\uff0c\u4e5f\u70ba\u5f8c\u7e8c\u5152\u7ae5\u816b\u7624\u7cbe\u51c6\u65b0\u85e5\u7814\u767c\u6307\u660e\u4e86\u512a\u8cea\u65b9\u5411\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u9818\u57df\u9577\u671f\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u6b64\u6b21\u5728ASCO\u5c55\u793a\u7684\u7814\u7a76\u70baAPG-115\u6cbb\u7642\u5152\u7ae5\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u6578\u64da\u9996\u6b21\u4eae\u76f8\uff0c\u521d\u6b65\u5c55\u73fe\u7684\u7642\u6548\u548c\u8010\u53d7\u6027\u4ee4\u4eba\u9f13\u821e\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-115\u6b64\u524d\u5df2\u7372CDE\u7d0d\u5165\u300e\u661f\u5149\u8a08\u5283\u300f\uff0c\u64ec\u958b\u767c\u7528\u65bc\u591a\u7a2e\u5152\u7ae5\u5be6\u9ad4\u7624\u3002\u6b64\u6b21\u5c55\u793a\u7684\u6578\u64da\u70ba\u9019\u4e00\u65b9\u5411\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u5faa\u8b49\u652f\u6301\u3002\u6211\u5011\u5c07\u52a0\u5feb\u63a8\u9032\u76f8\u95dc\u7814\u7a76\uff0c\u671f\u5f85\u65e9\u65e5\u70ba\u9019\u4e9b\u4e9f\u9700\u65b0\u7642\u6cd5\u7684\u5152\u7ae5\u60a3\u8005\u5e36\u4f86\u5e0c\u671b\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282026 ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology 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\u8a72\u9805\u7814\u7a76\u7684\u7814\u7a76\u8005\u3001\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u540c\u4ec1\u91ab\u9662\u5152\u79d1\u5f35\u8abc\u6559\u6388\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u5c24\u5176\u662f\u665a\u671f\u8edf\u7d44\u7e54\u8089\u7624\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u6b64\u6b21 APG-115 \u806f\u5408\u65b9\u6848\u4ea4\u51fa\u7684\u81e8\u5e8a\u6578\u64da\u610f\u7fa9\u91cd\u5927\u3002\u8a72\u51cb\u4ea1\u901a\u8def\u9776\u5411\u85e5\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\u8868\u73fe\u53ef\u89c0\uff0c\u5145\u5206\u5370\u8b49\u4e86\u96d9\u9776\u9ede\u806f\u5408\u6cbb\u7642\u5728\u5152\u7ae5\u96e3\u6cbb\u6027\u816b\u7624\u4e2d\u7684\u61c9\u7528\u50f9\u503c\uff0c\u4e5f\u70ba\u5f8c\u7e8c\u5152\u7ae5\u816b\u7624\u7cbe\u51c6\u65b0\u85e5\u7814\u767c\u6307\u660e\u4e86\u512a\u8cea\u65b9\u5411\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u9818\u57df\u9577\u671f\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u6b64\u6b21\u5728ASCO\u5c55\u793a\u7684\u7814\u7a76\u70baAPG-115\u6cbb\u7642\u5152\u7ae5\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u6578\u64da\u9996\u6b21\u4eae\u76f8\uff0c\u521d\u6b65\u5c55\u73fe\u7684\u7642\u6548\u548c\u8010\u53d7\u6027\u4ee4\u4eba\u9f13\u821e\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-115\u6b64\u524d\u5df2\u7372CDE\u7d0d\u5165\u300e\u661f\u5149\u8a08\u5283\u300f\uff0c\u64ec\u958b\u767c\u7528\u65bc\u591a\u7a2e\u5152\u7ae5\u5be6\u9ad4\u7624\u3002\u6b64\u6b21\u5c55\u793a\u7684\u6578\u64da\u70ba\u9019\u4e00\u65b9\u5411\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u5faa\u8b49\u652f\u6301\u3002\u6211\u5011\u5c07\u52a0\u5feb\u63a8\u9032\u76f8\u95dc\u7814\u7a76\uff0c\u671f\u5f85\u65e9\u65e5\u70ba\u9019\u4e9b\u4e9f\u9700\u65b0\u7642\u6cd5\u7684\u5152\u7ae5\u60a3\u8005\u5e36\u4f86\u5e0c\u671b\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282026 ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u7814\u7a76\u80cc\u666f\uff1a\u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u5be6\u9ad4\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002  \u7642\u6548\u6578\u64da\uff1a\u55ae\u85e5\u7d44 1 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\u8a72\u9805\u7814\u7a76\u7684\u7814\u7a76\u8005\u3001\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u540c\u4ec1\u91ab\u9662\u5152\u79d1\u5f35\u8abc\u6559\u6388\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u5c24\u5176\u662f\u665a\u671f\u8edf\u7d44\u7e54\u8089\u7624\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u6b64\u6b21 APG-115 \u806f\u5408\u65b9\u6848\u4ea4\u51fa\u7684\u81e8\u5e8a\u6578\u64da\u610f\u7fa9\u91cd\u5927\u3002\u8a72\u51cb\u4ea1\u901a\u8def\u9776\u5411\u85e5\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\u8868\u73fe\u53ef\u89c0\uff0c\u5145\u5206\u5370\u8b49\u4e86\u96d9\u9776\u9ede\u806f\u5408\u6cbb\u7642\u5728\u5152\u7ae5\u96e3\u6cbb\u6027\u816b\u7624\u4e2d\u7684\u61c9\u7528\u50f9\u503c\uff0c\u4e5f\u70ba\u5f8c\u7e8c\u5152\u7ae5\u816b\u7624\u7cbe\u51c6\u65b0\u85e5\u7814\u767c\u6307\u660e\u4e86\u512a\u8cea\u65b9\u5411\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u9818\u57df\u9577\u671f\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u6b64\u6b21\u5728ASCO\u5c55\u793a\u7684\u7814\u7a76\u70baAPG-115\u6cbb\u7642\u5152\u7ae5\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u6578\u64da\u9996\u6b21\u4eae\u76f8\uff0c\u521d\u6b65\u5c55\u73fe\u7684\u7642\u6548\u548c\u8010\u53d7\u6027\u4ee4\u4eba\u9f13\u821e\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-115\u6b64\u524d\u5df2\u7372CDE\u7d0d\u5165\u300e\u661f\u5149\u8a08\u5283\u300f\uff0c\u64ec\u958b\u767c\u7528\u65bc\u591a\u7a2e\u5152\u7ae5\u5be6\u9ad4\u7624\u3002\u6b64\u6b21\u5c55\u793a\u7684\u6578\u64da\u70ba\u9019\u4e00\u65b9\u5411\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u5faa\u8b49\u652f\u6301\u3002\u6211\u5011\u5c07\u52a0\u5feb\u63a8\u9032\u76f8\u95dc\u7814\u7a76\uff0c\u671f\u5f85\u65e9\u65e5\u70ba\u9019\u4e9b\u4e9f\u9700\u65b0\u7642\u6cd5\u7684\u5152\u7ae5\u60a3\u8005\u5e36\u4f86\u5e0c\u671b\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282026 ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u7814\u7a76\u80cc\u666f\uff1a\u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u5be6\u9ad4\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002  \u7642\u6548\u6578\u64da\uff1a\u55ae\u85e5\u7d44 1 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APG-115\u662f\u4e9e\u76db\u91ab\u85e5\u81ea\u4e3b\u7814\u767c\u7684\u53e3\u670d\u3001\u9ad8\u9078\u64c7\u6027MDM2-p53\u6291\u5236\u5291\uff0c\u70ba\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684\u540c\u985e\u9776\u9ede\u54c1\u7a2e\uff0c\u5177\u6709First-in-class\u6f5b\u529b\u3002\u8a72\u54c1\u7a2e\u901a\u904e\u963b\u65b7MDM2-p53\u76f8\u4e92\u4f5c\u7528\uff0c\u6062\u5fa9p53\u7684\u816b\u7624\u6291\u5236\u6d3b\u6027\uff0c\u5f9e\u800c\u8a98\u5c0e\u816b\u7624\u7d30\u80de\u51cb\u4ea1\u3002\u65e5\u524d\uff0cAPG-115\u5df2\u88ab\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6b63\u5f0f\u7d0d\u5165\u300c\u5152\u7ae5\u6297\u816b\u7624\u85e5\u7269\u7814\u767c\u9f13\u52f5\u8a66\u9ede\u8a08\u5283\u300d\uff08\u661f\u5149\u8a08\u5283\uff09\u8a66\u9ede\u9805\u76ee\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u3001\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u7b49\u5152\u7ae5\u5be6\u9ad4\u7624\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\u5f35\u7ffc\u9ddf\u6559\u6388\u8868\u793a\uff1a\u300c\u5fa9\u767c\/\u96e3\u6cbb\u6027\u5152\u7ae5\u8089\u7624\u9810\u5f8c\u6975\u5dee\uff0c\u81e8\u5e8a\u9700\u6c42\u8feb\u5207\u3002\u6b64\u6b21\u5728ASCO \u5c55\u793a\u7684\u6578\u64da\u8b49\u5be6\uff0cAPG-115 \u55ae\u85e5\u53ca\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\u5c55\u73fe\u51fa\u826f\u597d\u8010\u53d7\u6027\u8207\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5c24\u5176\u662fCR \u75c5\u4f8b\u4ee4\u4eba\u9f13\u821e\u3002\u4f5c\u70ba\u661f\u5149\u8a08\u5283\u91cd\u9ede\u54c1\u7a2e\uff0c\u5176First-in-class\u6f5b\u529b\u6709\u671b\u586b\u88dc\u6cbb\u7642\u7a7a\u767d\uff0c\u70ba\u60a3\u5152\u5e36\u4f86\u9577\u671f\u751f\u5b58\u65b0\u5e0c\u671b\u3002\u300d \u8a72\u9805\u7814\u7a76\u7684\u7814\u7a76\u8005\u3001\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u540c\u4ec1\u91ab\u9662\u5152\u79d1\u5f35\u8abc\u6559\u6388\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u5c24\u5176\u662f\u665a\u671f\u8edf\u7d44\u7e54\u8089\u7624\u81e8\u5e8a\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u6b64\u6b21 APG-115 \u806f\u5408\u65b9\u6848\u4ea4\u51fa\u7684\u81e8\u5e8a\u6578\u64da\u610f\u7fa9\u91cd\u5927\u3002\u8a72\u51cb\u4ea1\u901a\u8def\u9776\u5411\u85e5\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u5ba2\u89c0\u7de9\u89e3\u7387\u8868\u73fe\u53ef\u89c0\uff0c\u5145\u5206\u5370\u8b49\u4e86\u96d9\u9776\u9ede\u806f\u5408\u6cbb\u7642\u5728\u5152\u7ae5\u96e3\u6cbb\u6027\u816b\u7624\u4e2d\u7684\u61c9\u7528\u50f9\u503c\uff0c\u4e5f\u70ba\u5f8c\u7e8c\u5152\u7ae5\u816b\u7624\u7cbe\u51c6\u65b0\u85e5\u7814\u767c\u6307\u660e\u4e86\u512a\u8cea\u65b9\u5411\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u5152\u7ae5\u5be6\u9ad4\u7624\u9818\u57df\u9577\u671f\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u6b64\u6b21\u5728ASCO\u5c55\u793a\u7684\u7814\u7a76\u70baAPG-115\u6cbb\u7642\u5152\u7ae5\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u6578\u64da\u9996\u6b21\u4eae\u76f8\uff0c\u521d\u6b65\u5c55\u73fe\u7684\u7642\u6548\u548c\u8010\u53d7\u6027\u4ee4\u4eba\u9f13\u821e\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-115\u6b64\u524d\u5df2\u7372CDE\u7d0d\u5165\u300e\u661f\u5149\u8a08\u5283\u300f\uff0c\u64ec\u958b\u767c\u7528\u65bc\u591a\u7a2e\u5152\u7ae5\u5be6\u9ad4\u7624\u3002\u6b64\u6b21\u5c55\u793a\u7684\u6578\u64da\u70ba\u9019\u4e00\u65b9\u5411\u63d0\u4f9b\u4e86\u521d\u6b65\u7684\u5faa\u8b49\u652f\u6301\u3002\u6211\u5011\u5c07\u52a0\u5feb\u63a8\u9032\u76f8\u95dc\u7814\u7a76\uff0c\u671f\u5f85\u65e9\u65e5\u70ba\u9019\u4e9b\u4e9f\u9700\u65b0\u7642\u6cd5\u7684\u5152\u7ae5\u60a3\u8005\u5e36\u4f86\u5e0c\u671b\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282026 ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a\u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u5be6\u9ad4\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002 \u7642\u6548\u6578\u64da\uff1a\u55ae\u85e5\u7d44 1 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