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ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n<p><b>Updated efficacy and safety of Olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)<br \/><\/b><b>\u5967\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>HQP1351<\/b><b>\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08<\/b><b>CP-CML<\/b><b>\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>6510<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u5feb\u901f\u53e3\u982d\u5831\u544a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a <\/b><\/p>\n<ul type=\"disc\">\n<li><b>\u7814\u7a76\u80cc\u666f\uff1a<\/b>\u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002<\/li>\n<li><b>\u7642\u6548\u6578\u64da\uff1a<\/b>\u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u986f\u793a\u51fa\u986f\u8457\u4e14\u6301\u7e8c\u589e\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\u671f\uff0c\u6700\u4f73CCyR\u7387\u905476.2%\uff0c\u6700\u4f73MMR\u7387\u905447.6%\uff0c\u4e14\u7642\u6548\u96a8\u6cbb\u7642\u5468\u671f\u5ef6\u9577\u9010\u6b65\u63d0\u9ad8\uff0c\u5728\u7b2c24\u5468\u671f\u5206\u5225\u9054\u523091.3%\u548c60.9%\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u4e8c\u4ee3TKI\u6cbb\u7642\u7684\u60a3\u8005\u4e2d\u4ecd\u4fdd\u6301\u8f03\u9ad8\u7642\u6548\u3002<\/li>\n<li><b>\u5b89\u5168\u6027\u6578\u64da\uff1a<\/b>\u5b89\u5168\u6027\u65b9\u9762\uff0c\u7e3d\u9ad4\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u767c\u751f\u7387\u70ba89.4%\uff0c\u4f46\u591a\u70ba\u53ef\u63a7\u7684\u4f4e\u7b49\u7d1a\u53cd\u61c9\uff0c\u4e3b\u8981\u8868\u73fe\u70ba\u8272\u7d20\u6c89\u8457\u3001\u9ad8\u5c3f\u9178\u8840\u75c7\u548c\u808c\u9178\u6fc0\u9176\u5347\u9ad8\u7b49\uff1b\u96d6\u6709\u90e8\u5206\u22653\u7d1a\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u4f46\u5747\u5728\u652f\u6301\u6cbb\u7642\u5f8c\u6062\u5fa9\u3002<\/li>\n<li><b>\u7d50\u8ad6\uff1a<\/b>\u6574\u9ad4\u800c\u8a00\uff0c\u8a72\u85e5\u7269\u5728\u4fdd\u8b49\u53ef\u63a7\u5b89\u5168\u6027\u7684\u540c\u6642\uff0c\u5be6\u73fe\u4e86\u6301\u4e45\u4e14\u9010\u6b65\u589e\u5f37\u7684\u7642\u6548\uff0c\u5c55\u73fe\u51fa\u826f\u597d\u7684\u81e8\u5e8a\u61c9\u7528\u524d\u666f\u3002<\/li>\n<\/ul>\n<p><b>\u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/b><\/p>\n<p>\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\u3001\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u4ee5\u53ca\u86cb\u767d\u964d\u89e3\u5291\u3002<\/p>\n<p>\u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b<sup>\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u6cbb\u7642\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u548c\u52a0\u901f\u671f\uff08CML-AP\uff09\u60a3\u8005\uff0c\u4ee5\u53ca\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8a72\u85e5\u7269\u6240\u6709\u7372\u6279\u9069\u61c9\u75c7\u5747\u5df2\u88ab\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff08NRDL\uff09\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b<sup>\u00ae<\/sup>\u4e09\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\uff1a\u7372\u7f8e\u570bFDA\u548c\u6b50\u6d32EMA\u8a31\u53ef\u7684\u8a55\u4f30\u8010\u7acb\u514b<sup>\u00ae<\/sup>\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ 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