{"id":440710,"date":"2026-06-01T08:00:00","date_gmt":"2026-06-01T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=440710"},"modified":"2026-06-01T08:00:00","modified_gmt":"2026-06-01T00:00:00","slug":"%e5%be%b7%e6%98%87%e6%bf%9f%e9%86%ab%e8%97%a5%e5%9c%a8asco-2026%e5%85%ac%e5%b8%83elisrasib%ef%bc%88d3s-001%ef%bc%89%e4%b8%80%e7%b7%9a%e6%b2%bb%e7%99%82%e6%95%b8%e6%93%9a%ef%bc%9b%e6%96%b0%e4%b8%80","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=440710","title":{"rendered":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li>Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4<\/li>\n<li>Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7%<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2026\u5e746\u67081\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002<\/p>\n<p><b>Elisrasib<\/b><b>\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642<\/b><b>KRAS G12C<\/b><b>\u7a81\u8b8a<\/b><b>NSCLC<\/b><\/p>\n<p>Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002<\/p>\n<p>\u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002<\/p>\n<p>\u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002<\/p>\n<p><b>Elisrasib<\/b><b>\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642<\/b><b>KRAS G12C<\/b><b>\u7a81\u8b8a<\/b><b>NSCLC<\/b><\/p>\n<p>\u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002<\/p>\n<p>elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002<\/p>\n<p>\u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002<\/p>\n<p>\u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n<p><b>\u5c08\u5bb6\u9ede\u8a55<\/b><\/p>\n<p>\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d<\/p>\n<p>\u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d<\/p>\n<p><b>\u95dc\u65bc<\/b><b>Elisrasib<\/b><b>\uff08<\/b><b>D3S-001<\/b><b>\uff09<\/b><br \/>Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09<\/p>\n<p><b>\u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5<\/b><\/p>\n<p>\u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002<\/p>\n<p>\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a<a href=\"http:\/\/www.d3bio.com\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.d3bio.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Elisrasib\u55ae\u85e5\u5728KRA&#8230;<\/p>\n","protected":false},"author":16,"featured_media":440711,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-440710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4  Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7%  \u4e0a\u6d772026\u5e746\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002     \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002 Elisrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002 \u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC \u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002 elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002 \u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002 \u5c08\u5bb6\u9ede\u8a55 \u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09 \u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5 \u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1awww.d3bio.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=440710\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4  Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7%  \u4e0a\u6d772026\u5e746\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002     \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002 Elisrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002 \u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC \u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002 elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002 \u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002 \u5c08\u5bb6\u9ede\u8a55 \u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09 \u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5 \u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1awww.d3bio.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=440710\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-01T00:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n\t<meta property=\"og:image:width\" content=\"3000\" \/>\n\t<meta property=\"og:image:height\" content=\"1990\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548\",\"datePublished\":\"2026-06-01T00:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710\"},\"wordCount\":156,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/D3_BIO_DeShengJi_Logo.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710\",\"name\":\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/D3_BIO_DeShengJi_Logo.jpg\",\"datePublished\":\"2026-06-01T00:00:00+00:00\",\"description\":\"Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7% \u4e0a\u6d772026\u5e746\u67081\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\\\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002 Elisrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002 \u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC \u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002 elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002 \u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002 \u5c08\u5bb6\u9ede\u8a55 \u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09 \u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5 \u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1awww.d3bio.com\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/D3_BIO_DeShengJi_Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/06\\\/D3_BIO_DeShengJi_Logo.jpg\",\"width\":400,\"height\":225},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=440710#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4  Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7%  \u4e0a\u6d772026\u5e746\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002     \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002 Elisrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002 \u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC \u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002 elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002 \u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002 \u5c08\u5bb6\u9ede\u8a55 \u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09 \u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5 \u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1awww.d3bio.com","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=440710","og_locale":"zh_TW","og_type":"article","og_title":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4  Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7%  \u4e0a\u6d772026\u5e746\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002     \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002 Elisrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002 \u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC \u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002 elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002 \u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002 \u5c08\u5bb6\u9ede\u8a55 \u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09 \u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5 \u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1awww.d3bio.com","og_url":"https:\/\/pingtungtimes.com.tw\/?p=440710","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2026-06-01T00:00:00+00:00","og_image":[{"width":3000,"height":1990,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=440710"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548","datePublished":"2026-06-01T00:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=440710"},"wordCount":156,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/06\/D3_BIO_DeShengJi_Logo.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=440710","url":"https:\/\/pingtungtimes.com.tw\/?p=440710","name":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/06\/D3_BIO_DeShengJi_Logo.jpg","datePublished":"2026-06-01T00:00:00+00:00","description":"Elisrasib\u55ae\u85e5\u5728KRAS G12C\u7a81\u8b8a\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe78.0%\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u70ba12.4\u500b\u6708\uff08n=41\uff09\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u7642\u6548\u4e00\u81f4 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u5be6\u73fe81.3%\u7684ORR\uff08n=48\uff09\uff0c12\u500b\u6708PFS\u7387\u905453.7% \u4e0a\u6d772026\u5e746\u67081\u65e5 \/\u7f8e\u901a\u793e\/ -- \u5fb7\u6607\u6fdf\u91ab\u85e5\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u5275\u65b0\u816b\u7624\u7642\u6cd5\u958b\u767c\u7684\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u5176\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291elisrasib\uff08D3S-001\uff09\u5728\u4e00\u9805\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u7684\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u3002\u8a72\u7814\u7a76\u8a55\u4f30\u4e86elisrasib\u55ae\u85e5\u53ca\u5176\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u6cbb\u7642KRAS G12C\u7a81\u8b8a\uff08G12Cmut\uff09\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u76f8\u95dc\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u81e8\u5e8a\u79d1\u5b78\u5c08\u984c\u6703\u8b70\u4e0a\u516c\u5e03\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7121\u8ad6\u55ae\u85e5\u9084\u662f\u806f\u5408\u6cbb\u7642\u65b9\u6848\uff0celisrasib\u5728\u4e00\u7ddaG12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e26\u5728\u4e0d\u540cPD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5c55\u73fe\u51fa\u4ee4\u4eba\u632f\u596e\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u652f\u6301\u5176\u5728\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u9032\u4e00\u6b65\u958b\u767c\u3002 Elisrasib\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC Elisrasib\u55ae\u85e5\u7642\u6cd5\u5c55\u73fe\u51fa\u6975\u5177\u524d\u666f\u7684\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u8a72\u968a\u5217\u4e2d\uff0c\u5171\u670943\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\uff0821\u5929\u70ba\u4e00\u500b\u5468\u671f\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba8.5\u500b\u6708\u3002\u572841\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba78.0%\uff0c\u4e14\u5728\u4e0d\u540cPD-L1\u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba76.2%\uff08n=21\uff09\uff0cTPS \u22651%\u4eba\u7fa4\u70ba80.0%\uff08n=20\uff09\u3002\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba95.1%\u3002 \u4e2d\u4f4dPFS\u70ba12.4\u500b\u6708\uff0895% CI\uff1a6.8\uff0c\u672a\u9054\u5230\uff09\uff0c12\u500b\u6708PFS\u7387\u70ba50.8%\u3002\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba90.0%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c60.5%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0celisrasib\u55ae\u85e5\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u70ba7.0%\uff0c\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba2.3%\u3002\u672a\u767c\u751f\u56e0TRAE\u5c0e\u81f4\u7684\u505c\u85e5\u6216\u5291\u91cf\u4e0b\u8abf\u3002 Elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642KRAS G12C\u7a81\u8b8aNSCLC \u5728\u806f\u5408\u6cbb\u7642\u968a\u5217\u4e2d\uff0c\u5171\u670952\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u63a5\u53d7elisrasib 600 mg\u6bcf\u65e5\u4e00\u6b21\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297200 mg\u6bcf3\u5468\u4e00\u6b21\uff08Q3W\uff09\u6cbb\u7642\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba5.7\u500b\u6708\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u806f\u5408\u65b9\u6848\u4e2delisrasib\u7684\u7d66\u85e5\u5291\u91cf\u5373\u70ba\u5176RP2D\uff08600 mg QD\uff09\uff0c\u53ef\u5be6\u73fe\u5c0dKRAS G12C\u9776\u9ede\u7684\u5b8c\u5168\u8986\u84cb\u3002 elisrasib\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5728\u65e2\u5f80\u672a\u63a5\u53d7\u6cbb\u7642\u7684G12C\u7a81\u8b8aNSCLC\u60a3\u8005\u4e2d\u5c55\u73fe\u51fa\u6975\u5177\u8aaa\u670d\u529b\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u572848\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0cORR\u70ba81.3%\uff0c\u4e14\u5728\u5404PD-L1\u8868\u9054\u6c34\u5e73\u4eba\u7fa4\u4e2d\u5747\u89c0\u5bdf\u5230\u7642\u6548\uff1aPD-L1 TPS &lt;1%\u4eba\u7fa4ORR\u70ba70.6%\uff08n=17\uff09\uff0cTPS 1%\u201349%\u4eba\u7fa4\u70ba72.7%\uff08n=11\uff09\uff0cTPS \u226550%\u4eba\u7fa4\u70ba95.0%\uff08n=20\uff09\u3002DCR\u70ba97.9%\u3002 \u4e2d\u4f4dPFS\u5c1a\u672a\u9054\u5230\uff0895% CI\uff1a8.4\uff0c\u672a\u9054\u5230\uff09\uff0c6\u500b\u6708\u548c12\u500b\u6708PFS\u7387\u5206\u5225\u70ba74.6%\u548c53.7%\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c12\u500b\u6708OS\u7387\u70ba88.8%\u3002\u622a\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff0c82.7%\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7642\u3002 \u806f\u5408\u6cbb\u7642\u65b9\u6848\u7684\u5b89\u5168\u6027\u8207\u5404\u55ae\u85e5\u65e2\u5f80\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002\u22653\u7d1aTRAE\u767c\u751f\u7387\u70ba32.7%\uff0c\u5176\u4e2d\u5927\u591a\u6578\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u76f8\u95dc\uff1b\u56b4\u91cdTRAE\u767c\u751f\u7387\u70ba17.3%\u3002\u672a\u89c0\u5bdf\u5230elisrasib\u65b0\u7684\u6216\u975e\u9810\u671f\u5b89\u5168\u6027\u4fe1\u865f\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u512a\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u5316\u7642\u9019\u4e00\u7576\u524d\u6a19\u51c6\u6cbb\u7642\u65b9\u6848\u3002 \u5c08\u5bb6\u9ede\u8a55 \u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u6559\u6388\u3001\u672c\u6b21\u7814\u7a76\u5831\u544a\u4eba\u9678\u821c\u6559\u6388\u8868\u793a\uff1a\u300celisrasib\u4e00\u7dda\u6cbb\u7642\u6578\u64da\u4ee4\u4eba\u9f13\u821e\uff0c\u7121\u8ad6\u4f5c\u70ba\u55ae\u85e5\u9084\u662f\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u806f\u5408\u61c9\u7528\uff0c\u5728\u4e0d\u540c PD-L1 \u8868\u9054\u4e9e\u7d44\u4e2d\u5747\u5c55\u73fe\u51fa\u7a69\u5b9a\u5f37\u6548\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5176\u8010\u53d7\u6027\u826f\u597d\u4e14\u8d77\u6548\u8fc5\u901f\uff0c\u5145\u5206\u5f70\u986f\u4e86\u9019\u6b3e\u85e5\u7269\u7528\u65bc KRAS G12C \u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u300d \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u4e00\u7ddaNSCLC\u4e2d\u7684\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u5747\u5c55\u73fe\u51fa\u6975\u5177\u6f5b\u529b\u7684\u7642\u6548\u4fe1\u865f\uff0c\u70ba\u9019\u4e00\u9577\u671f\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u9078\u64c7\u7684\u4eba\u7fa4\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002\u6211\u5011\u76f8\u4fe1\uff0c\u9019\u4e9b\u7d50\u679c\u652f\u6301elisrasib\u5728III\u671f\u96a8\u6a5f\u7814\u7a76\u4e2d\u7684\u6301\u7e8c\u63a8\u9032\u548c\u52a0\u901f\u958b\u767c\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u5360\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u8303\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\u3002\uff09 \u95dc\u65bc\u5fb7\u6607\u6fdf\u91ab\u85e5 \u5fb7\u6607\u6fdf\u91ab\u85e5\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u6ce8\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u5fd7\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1awww.d3bio.com","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=440710"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/06\/D3_BIO_DeShengJi_Logo.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/06\/D3_BIO_DeShengJi_Logo.jpg","width":400,"height":225},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=440710#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728ASCO 2026\u516c\u5e03Elisrasib\uff08D3S-001\uff09\u4e00\u7dda\u6cbb\u7642\u6578\u64da\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u5728\u521d\u6cbbNSCLC\u4e2d\u5c55\u73fe\u88e1\u7a0b\u7891\u5f0f\u7642\u6548"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/440710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=440710"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/440710\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/440711"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=440710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=440710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=440710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}