{"id":440477,"date":"2026-05-31T08:00:00","date_gmt":"2026-05-31T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=440477"},"modified":"2026-05-31T08:00:00","modified_gmt":"2026-05-31T00:00:00","slug":"%e6%a6%ae%e7%99%bb%e3%80%8a%e6%9f%b3%e8%91%89%e5%88%80%e3%80%8b%e4%b8%bb%e5%88%8a%ef%bc%81%e8%98%86%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%96%ae%e6%8a%97sac-tmt%e8%81%af%e5%90%88%e5%b8%95%e5%8d%9a","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=440477","title":{"rendered":"\u69ae\u767b\u300a\u67f3\u8449\u5200\u300b\u4e3b\u520a\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642 PD-L1 \u967d\u6027 NSCLC III\u671f\u91cd\u78c5\u7d50\u679c\u767c\u8868"},"content":{"rendered":"
\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6210\u90fd<\/span>2026\u5e745\u670831\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2026\u5e745\u670831\u65e5\uff0c\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u4e0b\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d6990.HK)\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u9776\u5411\u4eba\u6ecb\u990a\u7d30\u80de\u8868\u9762\u6297\u539f2(TROP2)\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269(ADC)\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae<\/sup>)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae<\/sup>[1]<\/sup>\uff0c\u9ed8\u6c99\u6771\u7684\u6297\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d-1(PD-1)\u55ae\u6297)\u4e00\u7dda\u6cbb\u7642\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41(PD-L1)\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76(OptiTROP-Lung05)\u7d50\u679c\u69ae\u767b\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet<\/i>, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\u4e3b\u520a[2]<\/sup>\uff0c\u7531\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u53ca\u751f\u7269\u9776\u5411\u85e5\u7269\u570b\u5bb6\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u845b\u5747\u53cb\u535a\u58eb\u70ba\u5171\u540c\u8cc7\u6df1\u4f5c\u8005\uff1b\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u718a\u5b89\u7a69\u6559\u6388\u3001\u56db\u5ddd\u7701\u816b\u7624\u91ab\u9662\u59da\u6587\u79c0\u6559\u6388\u3001\u4e2d\u570b\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u76db\u4eac\u91ab\u9662\u912d\u5049\u6559\u6388\u3001\u54c8\u723e\u6ff1\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u65bc\u96c1\u6559\u6388\u3001\u5929\u6d25\u91ab\u79d1\u5927\u5b78\u816b\u7624\u91ab\u9662\u9673\u9d6c\u6559\u6388\u3001\u4e0a\u6d77\u5e02\u80f8\u79d1\u91ab\u9662\u937e\u83ef\u6559\u6388\u53ca\u751f\u7269\u9776\u5411\u85e5\u7269\u570b\u5bb6\u5de5\u7a0b\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u845b\u5747\u53cb\u535a\u58eb\u70ba\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u3002\u6b64\u7814\u7a76\u6210\u679c\u4ea6\u5165\u90782026 \u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u53e3\u982d\u532f\u5831\u74b0\u7bc0(\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c-\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)\u3002<\/p>\n

\n

\uff08Published online May 29, 2026; DOI:10.1016\/S0140-6736(26)00968-2\uff09<\/span><\/p>\n<\/p><\/div>\n

OptiTROP-Lung05\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u6027\u3001\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642PD-L1 TPS\u22651%\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/p>\n

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\u9019\u662f\u9996\u500bADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u5728NSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u9996\u6b21\u8b49\u660e\u4e86\u300cADC+IO\u300d\u65b9\u6848(sac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u4f5c\u70baNSCLC\u4e00\u7dda\u6cbb\u7642\u5177\u6709\u5be6\u73fe\u751f\u5b58\u7372\u76ca\u7684\u6f5b\u529b\u3002\u8a72\u6210\u679c\u554f\u9f0e\u300a\u67f3\u8449\u5200\u300b\u4e3b\u520a\uff0c\u8868\u660e\u9019\u4e00\u7642\u6cd5\u7684\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u6b0a\u5a01\u8a8d\u53ef\u3002<\/p>\n

\u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297<\/u><\/b>(sac-TMT)(<\/u><\/b>\u4f73\u6cf0\u840a<\/u><\/b>\u00ae<\/sup><\/u><\/b>)<\/u><\/b><\/p>\n

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\u95dc\u65bc\u79d1\u502b\u535a\u6cf0<\/u><\/b><\/p>\n

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[1]<\/sup> \u53ef\u745e\u9054\u00ae<\/sup>(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2]<\/sup> https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(26)00968-2\/fulltext<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u00a0<\/p>\n

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\u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19 https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(26)00968-2\/fulltext \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=440477\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u69ae\u767b\u300a\u67f3\u8449\u5200\u300b\u4e3b\u520a\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642 PD-L1 \u967d\u6027 NSCLC III\u671f\u91cd\u78c5\u7d50\u679c\u767c\u8868 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" 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2026\u5e745\u670831\u65e5\uff0c\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u4e0b\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d6990.HK)\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u9776\u5411\u4eba\u6ecb\u990a\u7d30\u80de\u8868\u9762\u6297\u539f2(TROP2)\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269(ADC)\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae\uff0c\u9ed8\u6c99\u6771\u7684\u6297\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d-1(PD-1)\u55ae\u6297)\u4e00\u7dda\u6cbb\u7642\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41(PD-L1)\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76(OptiTROP-Lung05)\u7d50\u679c\u69ae\u767b\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet, 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\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u53e3\u982d\u532f\u5831\u74b0\u7bc0(\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c-\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)\u3002 \uff08Published online May 29, 2026; DOI:10.1016\/S0140-6736(26)00968-2\uff09 OptiTROP-Lung05\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u958b\u653e\u6027\u3001\u591a\u4e2d\u5fc3III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u4e00\u7dda\u6cbb\u7642PD-L1 TPS\u22651%\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002 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