{"id":440262,"date":"2026-05-30T12:30:00","date_gmt":"2026-05-30T04:30:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=440262"},"modified":"2026-05-30T12:30:00","modified_gmt":"2026-05-30T04:30:00","slug":"2026-asco-%e8%98%86%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%96%ae%e6%8a%97sac-tmt-iii%e6%9c%9foptitrop-lung05%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e6%96%bcasco%e5%8f%a3%e9%a0%ad%e5%a0%b1%e5%91%8a","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=440262","title":{"rendered":"2026 ASCO | \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) III\u671fOptiTROP-Lung05\u7814\u7a76\u6210\u679c\u65bcASCO\u53e3\u982d\u5831\u544a\u548c\u300a\u67f3\u8449\u5200\u300b\u540c\u6b65\u767c\u4f48"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2650617\/logo_kelun_Biotech_Logo.jpg?p=medium600\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\">\u6210\u90fd<\/span><span class=\"legendSpanClass\">2026\u5e745\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 2026\u5e745\u670830\u65e5\uff0c\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u4e0b\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d\u00a06990.HK)\u5ba3\u4f48\uff0c\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u884c\u76842026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u4e0a\uff0c\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\u4e86TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a<sup>\u00ae<\/sup>)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054<sup>\u00ae<\/sup><sup>[1]<\/sup>\uff0c\u9ed8\u6c99\u6771\u7684\u6297\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d-1(PD-1)\u55ae\u6297)\u4e00\u7dda\u6cbb\u7642\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41(PD-L1)\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684III\u671fOptiTROP-Lung05\u7814\u7a76\u7d50\u679c(\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c-\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder3291\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><span><\/span><\/p>\n<\/p><\/div>\n<p>\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u4ee5\u53ca\u57fa\u65bc\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u7684\u5dee\u7570\u5316\u6709\u6548\u8f09\u8377\u8a2d\u8a08\u3002\u5176\u9023\u63a5\u5b50\u901a\u904e\u534a\u80f1\u6c28\u9178\u5076\u806f\uff0c\u4e00\u65b9\u9762\u8207\u5177\u6709\u9ad8\u89aa\u548c\u529b\u53ca\u9776\u5411\u6548\u61c9\u7684TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u4e2d\u7b49\u6bd2\u6027\u65b0\u578b\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder5567\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991304\/image2.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991304\/image2.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u5728OptiTROP-Lung05\u7814\u7a76\u4e2d\uff0c\u5171\u6709413\u4f8b\u60a3\u8005\u88ab\u96a8\u6a5f(1:1)\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder5629\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991305\/image3.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991305\/image3.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u65bc\u6578\u64da\u622a\u6b62\u6642\u9593(2025\u5e749\u670829\u65e5)\uff0c\u4e2d\u4f4d\u96a8\u8a2a10.5\u500b\u6708\uff0c\u7814\u7a76\u6578\u64da\u986f\u793a\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u986f\u793a\u51fa\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u986f\u8457\u6539\u5584\u3002\u7531\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9(BICR)\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(HR=0.35; 95% CI: 0.26-0.47; p&lt;0.0001)\uff0c12\u500b\u6708PFS\u7387\u70ba62.4% vs 29.0%\u3002<\/li>\n<\/ul>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder5331\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991306\/image4.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991306\/image4.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<ul type=\"disc\">\n<li>\u9810\u8a2d\u5404\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS\u226550%\u53caTPS 1-49%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.47 (95% CI: 0.29-0.77)\u548c0.28 (95% CI: 0.19-0.41)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002<\/li>\n<\/ul>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2870\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991307\/image5.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991307\/image5.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u00a0<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder3461\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991308\/image6.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991308\/image6.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<ul type=\"disc\">\n<li>\u7e3d\u751f\u5b58\u671f(OS)\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\uff1a\u4e2d\u4f4dOS\u5206\u5225\u70baNR vs 14.5\u500b\u6708(HR=0.55\uff1b95% CI: 0.36-0.85)\uff1b12\u500b\u6708OS\u7387\u70ba80.4% vs 68.9%\u3002<\/li>\n<li>\u806f\u5408\u6cbb\u7642\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u63d0\u9ad8\u4e86\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)(70.2% vs 42.0%)\u3001\u6df1\u5ea6\u7de9\u89e3\u7387(49.0% vs 25.9%) \u53ca12\u500b\u6708\u6301\u7e8c\u7de9\u89e3\u7387(77.7% vs 59.4%)\u3002<\/li>\n<\/ul>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder5915\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991309\/image7.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991309\/image7.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br \/><span><\/span><\/p>\n<\/p><\/div>\n<p>\u806f\u5408\u6cbb\u7642\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u66f4\u9ad8\uff0c\u4e3b\u8981\u662f\u7531\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u9810\u671f\u767c\u751f\u7684\u8840\u6db2\u5b78\u4e0d\u826f\u4e8b\u4ef6\u6240\u81f4\uff1b\u5169\u7d44\u56e0TEAEs\u5c0e\u81f4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u767c\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u767c\u751f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u76f8\u95dc\u7684\u6b7b\u4ea1\uff1b\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6(AEOSIs)\u8207\u5404\u8a66\u9a57\u85e5\u7269\u5df2\u77e5\u7684\u4e0d\u826f\u53cd\u61c9\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/p>\n<p>\u671f\u4e2d\u5206\u6790\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u5ef6\u9577PFS\u4e26\u964d\u4f4e\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff0c\u4e14\u9810\u8a2d\u7684\u5404\u4e9e\u7d44\u4e2d(\u5305\u62ecPD-L1\u8868\u9054\u6c34\u5e73\u3001\u7d44\u7e54\u5b78\u985e\u578b)\u5747\u8868\u73fe\u51fa\u4e00\u81f4\u7684PFS\u7372\u76ca\uff1b\u540c\u6642\u5df2\u89c0\u5bdf\u5230OS\u7684\u7372\u76ca\u8da8\u52e2\u3002\u806f\u5408\u6cbb\u7642\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u8207\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u5df2\u5efa\u7acb\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002<\/p>\n<p>\u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0cOptiTROP\u2011Lung05\u7814\u7a76\u6210\u679c\u5df2\u540c\u6b65\u520a\u767b\u570b\u969b\u9802\u520a\u300a\u67f3\u8449\u5200\u300b\uff08<i>The Lancet<\/i>, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\uff0c\u8aaa\u660e\u5176\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u4e00\u6d41\u5b78\u6703\u53ca\u6b0a\u5a01\u671f\u520a\u7684\u96d9\u91cd\u8a8d\u53ef\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder7978\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><a href=\"https:\/\/mma.prnasia.com\/media2\/2991310\/image8.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\"><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2991310\/image8.jpg?p=medium600\" title=\"\" alt=\"\"><\/a><br 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III\u671fOptiTROP-Lung05\u7814\u7a76\u6210\u679c\u65bcASCO\u53e3\u982d\u5831\u544a\u548c\u300a\u67f3\u8449\u5200\u300b\u540c\u6b65\u767c\u4f48 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u6210\u90fd2026\u5e745\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- 2026\u5e745\u670830\u65e5\uff0c\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u4e0b\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d\u00a06990.HK)\u5ba3\u4f48\uff0c\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u884c\u76842026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u4e0a\uff0c\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\u4e86TROP2 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\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u4ee5\u53ca\u57fa\u65bc\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u7684\u5dee\u7570\u5316\u6709\u6548\u8f09\u8377\u8a2d\u8a08\u3002\u5176\u9023\u63a5\u5b50\u901a\u904e\u534a\u80f1\u6c28\u9178\u5076\u806f\uff0c\u4e00\u65b9\u9762\u8207\u5177\u6709\u9ad8\u89aa\u548c\u529b\u53ca\u9776\u5411\u6548\u61c9\u7684TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u4e2d\u7b49\u6bd2\u6027\u65b0\u578b\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002     \u5728OptiTROP-Lung05\u7814\u7a76\u4e2d\uff0c\u5171\u6709413\u4f8b\u60a3\u8005\u88ab\u96a8\u6a5f(1:1)\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u3002     \u65bc\u6578\u64da\u622a\u6b62\u6642\u9593(2025\u5e749\u670829\u65e5)\uff0c\u4e2d\u4f4d\u96a8\u8a2a10.5\u500b\u6708\uff0c\u7814\u7a76\u6578\u64da\u986f\u793a\uff1a   \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u986f\u793a\u51fa\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u986f\u8457\u6539\u5584\u3002\u7531\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9(BICR)\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(HR=0.35; 95% CI: 0.26-0.47; p&lt;0.0001)\uff0c12\u500b\u6708PFS\u7387\u70ba62.4% vs 29.0%\u3002       \u9810\u8a2d\u5404\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS\u226550%\u53caTPS 1-49%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.47 (95% CI: 0.29-0.77)\u548c0.28 (95% CI: 0.19-0.41)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002      \u00a0      \u7e3d\u751f\u5b58\u671f(OS)\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\uff1a\u4e2d\u4f4dOS\u5206\u5225\u70baNR vs 14.5\u500b\u6708(HR=0.55\uff1b95% CI: 0.36-0.85)\uff1b12\u500b\u6708OS\u7387\u70ba80.4% vs 68.9%\u3002  \u806f\u5408\u6cbb\u7642\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u63d0\u9ad8\u4e86\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)(70.2% vs 42.0%)\u3001\u6df1\u5ea6\u7de9\u89e3\u7387(49.0% vs 25.9%) \u53ca12\u500b\u6708\u6301\u7e8c\u7de9\u89e3\u7387(77.7% vs 59.4%)\u3002      \u806f\u5408\u6cbb\u7642\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u66f4\u9ad8\uff0c\u4e3b\u8981\u662f\u7531\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u9810\u671f\u767c\u751f\u7684\u8840\u6db2\u5b78\u4e0d\u826f\u4e8b\u4ef6\u6240\u81f4\uff1b\u5169\u7d44\u56e0TEAEs\u5c0e\u81f4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u767c\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u767c\u751f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u76f8\u95dc\u7684\u6b7b\u4ea1\uff1b\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6(AEOSIs)\u8207\u5404\u8a66\u9a57\u85e5\u7269\u5df2\u77e5\u7684\u4e0d\u826f\u53cd\u61c9\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u671f\u4e2d\u5206\u6790\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u5ef6\u9577PFS\u4e26\u964d\u4f4e\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff0c\u4e14\u9810\u8a2d\u7684\u5404\u4e9e\u7d44\u4e2d(\u5305\u62ecPD-L1\u8868\u9054\u6c34\u5e73\u3001\u7d44\u7e54\u5b78\u985e\u578b)\u5747\u8868\u73fe\u51fa\u4e00\u81f4\u7684PFS\u7372\u76ca\uff1b\u540c\u6642\u5df2\u89c0\u5bdf\u5230OS\u7684\u7372\u76ca\u8da8\u52e2\u3002\u806f\u5408\u6cbb\u7642\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u8207\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u5df2\u5efa\u7acb\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002 \u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0cOptiTROP\u2011Lung05\u7814\u7a76\u6210\u679c\u5df2\u540c\u6b65\u520a\u767b\u570b\u969b\u9802\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\uff0c\u8aaa\u660e\u5176\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u4e00\u6d41\u5b78\u6703\u53ca\u6b0a\u5a01\u671f\u520a\u7684\u96d9\u91cd\u8a8d\u53ef\u3002     \u5168\u570b\u727d\u982d\u4e3b\u8981\u7814\u7a76\u8005\u3001\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u8868\u793a\uff1a\u300cOptiTROP-Lung05\u7814\u7a76\u53d6\u5f97\u7684\u7a4d\u6975\u7d50\u679c\u4ee4\u4eba\u632f\u596e\u3002\u4e0d\u50c5\u70ba\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u5728\u80ba\u764c\u6cbb\u7642\u4e2d\u7684\u300e\u61c9\u7528\u524d\u79fb\u300f\u63d0\u4f9b\u4e86\u5faa\u8b49\u8b49\u64da\uff0c\u66f4\u7387\u5148\u9a57\u8b49\u4e86\u300eADC+IO\u300f\u5354\u540c\u7b56\u7565\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u53ef\u884c\u6027\uff0c\u6709\u671b\u70ba\u5ee3\u5927\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u5168\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u300d           \u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp &amp; Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u8a3b\u518a\u5546\u6a19        \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u65b0\u578bTROP2 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\/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=440262\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2026 ASCO | \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) III\u671fOptiTROP-Lung05\u7814\u7a76\u6210\u679c\u65bcASCO\u53e3\u982d\u5831\u544a\u548c\u300a\u67f3\u8449\u5200\u300b\u540c\u6b65\u767c\u4f48 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u6210\u90fd2026\u5e745\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- 2026\u5e745\u670830\u65e5\uff0c\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u4e0b\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d\u00a06990.HK)\u5ba3\u4f48\uff0c\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u884c\u76842026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u4e0a\uff0c\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\u4e86TROP2 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\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u4ee5\u53ca\u57fa\u65bc\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u7684\u5dee\u7570\u5316\u6709\u6548\u8f09\u8377\u8a2d\u8a08\u3002\u5176\u9023\u63a5\u5b50\u901a\u904e\u534a\u80f1\u6c28\u9178\u5076\u806f\uff0c\u4e00\u65b9\u9762\u8207\u5177\u6709\u9ad8\u89aa\u548c\u529b\u53ca\u9776\u5411\u6548\u61c9\u7684TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u4e2d\u7b49\u6bd2\u6027\u65b0\u578b\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002     \u5728OptiTROP-Lung05\u7814\u7a76\u4e2d\uff0c\u5171\u6709413\u4f8b\u60a3\u8005\u88ab\u96a8\u6a5f(1:1)\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u3002     \u65bc\u6578\u64da\u622a\u6b62\u6642\u9593(2025\u5e749\u670829\u65e5)\uff0c\u4e2d\u4f4d\u96a8\u8a2a10.5\u500b\u6708\uff0c\u7814\u7a76\u6578\u64da\u986f\u793a\uff1a   \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u986f\u793a\u51fa\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u986f\u8457\u6539\u5584\u3002\u7531\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9(BICR)\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(HR=0.35; 95% CI: 0.26-0.47; p&lt;0.0001)\uff0c12\u500b\u6708PFS\u7387\u70ba62.4% vs 29.0%\u3002       \u9810\u8a2d\u5404\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS\u226550%\u53caTPS 1-49%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.47 (95% CI: 0.29-0.77)\u548c0.28 (95% CI: 0.19-0.41)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002      \u00a0      \u7e3d\u751f\u5b58\u671f(OS)\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\uff1a\u4e2d\u4f4dOS\u5206\u5225\u70baNR vs 14.5\u500b\u6708(HR=0.55\uff1b95% CI: 0.36-0.85)\uff1b12\u500b\u6708OS\u7387\u70ba80.4% vs 68.9%\u3002  \u806f\u5408\u6cbb\u7642\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u63d0\u9ad8\u4e86\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)(70.2% vs 42.0%)\u3001\u6df1\u5ea6\u7de9\u89e3\u7387(49.0% vs 25.9%) \u53ca12\u500b\u6708\u6301\u7e8c\u7de9\u89e3\u7387(77.7% vs 59.4%)\u3002      \u806f\u5408\u6cbb\u7642\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u66f4\u9ad8\uff0c\u4e3b\u8981\u662f\u7531\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u9810\u671f\u767c\u751f\u7684\u8840\u6db2\u5b78\u4e0d\u826f\u4e8b\u4ef6\u6240\u81f4\uff1b\u5169\u7d44\u56e0TEAEs\u5c0e\u81f4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u767c\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u767c\u751f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u76f8\u95dc\u7684\u6b7b\u4ea1\uff1b\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6(AEOSIs)\u8207\u5404\u8a66\u9a57\u85e5\u7269\u5df2\u77e5\u7684\u4e0d\u826f\u53cd\u61c9\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u671f\u4e2d\u5206\u6790\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u5ef6\u9577PFS\u4e26\u964d\u4f4e\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff0c\u4e14\u9810\u8a2d\u7684\u5404\u4e9e\u7d44\u4e2d(\u5305\u62ecPD-L1\u8868\u9054\u6c34\u5e73\u3001\u7d44\u7e54\u5b78\u985e\u578b)\u5747\u8868\u73fe\u51fa\u4e00\u81f4\u7684PFS\u7372\u76ca\uff1b\u540c\u6642\u5df2\u89c0\u5bdf\u5230OS\u7684\u7372\u76ca\u8da8\u52e2\u3002\u806f\u5408\u6cbb\u7642\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u8207\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u5df2\u5efa\u7acb\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002 \u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0cOptiTROP\u2011Lung05\u7814\u7a76\u6210\u679c\u5df2\u540c\u6b65\u520a\u767b\u570b\u969b\u9802\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\uff0c\u8aaa\u660e\u5176\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u4e00\u6d41\u5b78\u6703\u53ca\u6b0a\u5a01\u671f\u520a\u7684\u96d9\u91cd\u8a8d\u53ef\u3002     \u5168\u570b\u727d\u982d\u4e3b\u8981\u7814\u7a76\u8005\u3001\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u8868\u793a\uff1a\u300cOptiTROP-Lung05\u7814\u7a76\u53d6\u5f97\u7684\u7a4d\u6975\u7d50\u679c\u4ee4\u4eba\u632f\u596e\u3002\u4e0d\u50c5\u70ba\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u5728\u80ba\u764c\u6cbb\u7642\u4e2d\u7684\u300e\u61c9\u7528\u524d\u79fb\u300f\u63d0\u4f9b\u4e86\u5faa\u8b49\u8b49\u64da\uff0c\u66f4\u7387\u5148\u9a57\u8b49\u4e86\u300eADC+IO\u300f\u5354\u540c\u7b56\u7565\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u53ef\u884c\u6027\uff0c\u6709\u671b\u70ba\u5ee3\u5927\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u5168\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u300d           \u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp &amp; Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u8a3b\u518a\u5546\u6a19        \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0dNSCLC\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u53ca\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7d71\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u958b\u767c\u800c\u6210\u3002\u8a72\u9023\u63a5\u5b50\u4e00\u65b9\u9762\u901a\u904e\u8207\u6297TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u5f62\u6210\u4e0d\u53ef\u9006\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u5f9e\u800c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u53f0\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a1)\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c(TNBC)\uff1b2)\u7d93\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4-\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291(EGFR-TKI)\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(EGFR)\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b3)\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b4)\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027(HR+)\u4e14\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad42\u9670\u6027(HER2-) (\u514d\u75ab\u7d44\u7e54\u5316\u5b78(IHC) 0\u3001IHC 1+\u6216IHC 2+\/\u539f\u4f4d\u96dc\u4ea4(ISH)-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 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p&lt;0.0001)\uff0c12\u500b\u6708PFS\u7387\u70ba62.4% vs 29.0%\u3002 \u9810\u8a2d\u5404\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS\u226550%\u53caTPS 1-49%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.47 (95% CI: 0.29-0.77)\u548c0.28 (95% CI: 0.19-0.41)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002 \u00a0 \u7e3d\u751f\u5b58\u671f(OS)\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\uff1a\u4e2d\u4f4dOS\u5206\u5225\u70baNR vs 14.5\u500b\u6708(HR=0.55\uff1b95% CI: 0.36-0.85)\uff1b12\u500b\u6708OS\u7387\u70ba80.4% vs 68.9%\u3002 \u806f\u5408\u6cbb\u7642\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u63d0\u9ad8\u4e86\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)(70.2% vs 42.0%)\u3001\u6df1\u5ea6\u7de9\u89e3\u7387(49.0% vs 25.9%) \u53ca12\u500b\u6708\u6301\u7e8c\u7de9\u89e3\u7387(77.7% vs 59.4%)\u3002 \u806f\u5408\u6cbb\u7642\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u66f4\u9ad8\uff0c\u4e3b\u8981\u662f\u7531\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u9810\u671f\u767c\u751f\u7684\u8840\u6db2\u5b78\u4e0d\u826f\u4e8b\u4ef6\u6240\u81f4\uff1b\u5169\u7d44\u56e0TEAEs\u5c0e\u81f4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u767c\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u767c\u751f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u76f8\u95dc\u7684\u6b7b\u4ea1\uff1b\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6(AEOSIs)\u8207\u5404\u8a66\u9a57\u85e5\u7269\u5df2\u77e5\u7684\u4e0d\u826f\u53cd\u61c9\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u671f\u4e2d\u5206\u6790\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u5ef6\u9577PFS\u4e26\u964d\u4f4e\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff0c\u4e14\u9810\u8a2d\u7684\u5404\u4e9e\u7d44\u4e2d(\u5305\u62ecPD-L1\u8868\u9054\u6c34\u5e73\u3001\u7d44\u7e54\u5b78\u985e\u578b)\u5747\u8868\u73fe\u51fa\u4e00\u81f4\u7684PFS\u7372\u76ca\uff1b\u540c\u6642\u5df2\u89c0\u5bdf\u5230OS\u7684\u7372\u76ca\u8da8\u52e2\u3002\u806f\u5408\u6cbb\u7642\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u8207\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u5df2\u5efa\u7acb\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002 \u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0cOptiTROP\u2011Lung05\u7814\u7a76\u6210\u679c\u5df2\u540c\u6b65\u520a\u767b\u570b\u969b\u9802\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\uff0c\u8aaa\u660e\u5176\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u4e00\u6d41\u5b78\u6703\u53ca\u6b0a\u5a01\u671f\u520a\u7684\u96d9\u91cd\u8a8d\u53ef\u3002 \u5168\u570b\u727d\u982d\u4e3b\u8981\u7814\u7a76\u8005\u3001\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u8868\u793a\uff1a\u300cOptiTROP-Lung05\u7814\u7a76\u53d6\u5f97\u7684\u7a4d\u6975\u7d50\u679c\u4ee4\u4eba\u632f\u596e\u3002\u4e0d\u50c5\u70ba\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u5728\u80ba\u764c\u6cbb\u7642\u4e2d\u7684\u300e\u61c9\u7528\u524d\u79fb\u300f\u63d0\u4f9b\u4e86\u5faa\u8b49\u8b49\u64da\uff0c\u66f4\u7387\u5148\u9a57\u8b49\u4e86\u300eADC+IO\u300f\u5354\u540c\u7b56\u7565\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u53ef\u884c\u6027\uff0c\u6709\u671b\u70ba\u5ee3\u5927\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u5168\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u300d \u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp &amp; Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u8a3b\u518a\u5546\u6a19 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0dNSCLC\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u53ca\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7d71\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u958b\u767c\u800c\u6210\u3002\u8a72\u9023\u63a5\u5b50\u4e00\u65b9\u9762\u901a\u904e\u8207\u6297TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u5f62\u6210\u4e0d\u53ef\u9006\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u5f9e\u800c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u53f0\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a1)\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c(TNBC)\uff1b2)\u7d93\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4-\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291(EGFR-TKI)\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(EGFR)\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b3)\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b4)\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4\u967d\u6027(HR+)\u4e14\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad42\u9670\u6027(HER2-) (\u514d\u75ab\u7d44\u7e54\u5316\u5b78(IHC) 0\u3001IHC 1+\u6216IHC 2+\\\/\u539f\u4f4d\u96dc\u4ea4(ISH)-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 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ASCO | \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) III\u671fOptiTROP-Lung05\u7814\u7a76\u6210\u679c\u65bcASCO\u53e3\u982d\u5831\u544a\u548c\u300a\u67f3\u8449\u5200\u300b\u540c\u6b65\u767c\u4f48 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u6210\u90fd2026\u5e745\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- 2026\u5e745\u670830\u65e5\uff0c\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u4e0b\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u516c\u53f8\u300d\u00a06990.HK)\u5ba3\u4f48\uff0c\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u884c\u76842026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u4e0a\uff0c\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\u4e86TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae\uff0c\u9ed8\u6c99\u6771\u7684\u6297\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d-1(PD-1)\u55ae\u6297)\u4e00\u7dda\u6cbb\u7642\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41(PD-L1)\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684III\u671fOptiTROP-Lung05\u7814\u7a76\u7d50\u679c(\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c-\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)\u3002     \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u4ee5\u53ca\u57fa\u65bc\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u7684\u5dee\u7570\u5316\u6709\u6548\u8f09\u8377\u8a2d\u8a08\u3002\u5176\u9023\u63a5\u5b50\u901a\u904e\u534a\u80f1\u6c28\u9178\u5076\u806f\uff0c\u4e00\u65b9\u9762\u8207\u5177\u6709\u9ad8\u89aa\u548c\u529b\u53ca\u9776\u5411\u6548\u61c9\u7684TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u4e2d\u7b49\u6bd2\u6027\u65b0\u578b\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002     \u5728OptiTROP-Lung05\u7814\u7a76\u4e2d\uff0c\u5171\u6709413\u4f8b\u60a3\u8005\u88ab\u96a8\u6a5f(1:1)\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u3002     \u65bc\u6578\u64da\u622a\u6b62\u6642\u9593(2025\u5e749\u670829\u65e5)\uff0c\u4e2d\u4f4d\u96a8\u8a2a10.5\u500b\u6708\uff0c\u7814\u7a76\u6578\u64da\u986f\u793a\uff1a   \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u986f\u793a\u51fa\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u986f\u8457\u6539\u5584\u3002\u7531\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9(BICR)\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(HR=0.35; 95% CI: 0.26-0.47; p&lt;0.0001)\uff0c12\u500b\u6708PFS\u7387\u70ba62.4% vs 29.0%\u3002       \u9810\u8a2d\u5404\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS\u226550%\u53caTPS 1-49%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.47 (95% CI: 0.29-0.77)\u548c0.28 (95% CI: 0.19-0.41)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002      \u00a0      \u7e3d\u751f\u5b58\u671f(OS)\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\uff1a\u4e2d\u4f4dOS\u5206\u5225\u70baNR vs 14.5\u500b\u6708(HR=0.55\uff1b95% CI: 0.36-0.85)\uff1b12\u500b\u6708OS\u7387\u70ba80.4% vs 68.9%\u3002  \u806f\u5408\u6cbb\u7642\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u63d0\u9ad8\u4e86\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)(70.2% vs 42.0%)\u3001\u6df1\u5ea6\u7de9\u89e3\u7387(49.0% vs 25.9%) \u53ca12\u500b\u6708\u6301\u7e8c\u7de9\u89e3\u7387(77.7% vs 59.4%)\u3002      \u806f\u5408\u6cbb\u7642\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u66f4\u9ad8\uff0c\u4e3b\u8981\u662f\u7531\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u9810\u671f\u767c\u751f\u7684\u8840\u6db2\u5b78\u4e0d\u826f\u4e8b\u4ef6\u6240\u81f4\uff1b\u5169\u7d44\u56e0TEAEs\u5c0e\u81f4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u767c\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u767c\u751f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u76f8\u95dc\u7684\u6b7b\u4ea1\uff1b\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6(AEOSIs)\u8207\u5404\u8a66\u9a57\u85e5\u7269\u5df2\u77e5\u7684\u4e0d\u826f\u53cd\u61c9\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u671f\u4e2d\u5206\u6790\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u5ef6\u9577PFS\u4e26\u964d\u4f4e\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff0c\u4e14\u9810\u8a2d\u7684\u5404\u4e9e\u7d44\u4e2d(\u5305\u62ecPD-L1\u8868\u9054\u6c34\u5e73\u3001\u7d44\u7e54\u5b78\u985e\u578b)\u5747\u8868\u73fe\u51fa\u4e00\u81f4\u7684PFS\u7372\u76ca\uff1b\u540c\u6642\u5df2\u89c0\u5bdf\u5230OS\u7684\u7372\u76ca\u8da8\u52e2\u3002\u806f\u5408\u6cbb\u7642\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u8207\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u5df2\u5efa\u7acb\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002 \u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0cOptiTROP\u2011Lung05\u7814\u7a76\u6210\u679c\u5df2\u540c\u6b65\u520a\u767b\u570b\u969b\u9802\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\uff0c\u8aaa\u660e\u5176\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u4e00\u6d41\u5b78\u6703\u53ca\u6b0a\u5a01\u671f\u520a\u7684\u96d9\u91cd\u8a8d\u53ef\u3002     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ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae\uff0c\u9ed8\u6c99\u6771\u7684\u6297\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u86cb\u767d-1(PD-1)\u55ae\u6297)\u4e00\u7dda\u6cbb\u7642\u7a0b\u5e8f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41(PD-L1)\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u7684III\u671fOptiTROP-Lung05\u7814\u7a76\u7d50\u679c(\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c-\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u7368\u7279\u96d9\u529f\u80fd\u9023\u63a5\u5b50\u4ee5\u53ca\u57fa\u65bc\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u7684\u5dee\u7570\u5316\u6709\u6548\u8f09\u8377\u8a2d\u8a08\u3002\u5176\u9023\u63a5\u5b50\u901a\u904e\u534a\u80f1\u6c28\u9178\u5076\u806f\uff0c\u4e00\u65b9\u9762\u8207\u5177\u6709\u9ad8\u89aa\u548c\u529b\u53ca\u9776\u5411\u6548\u61c9\u7684TROP2\u55ae\u6297\u6c99\u59a5\u73e0\u55ae\u6297\u7d50\u5408\uff0c\u53e6\u4e00\u65b9\u9762\u5728\u6eb6\u9176\u9ad4\u4e2d\u53ef\u5f9e\u4e2d\u7b49\u6bd2\u6027\u65b0\u578b\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u6709\u6548\u8f09\u8377pH\u654f\u611f\u88c2\u89e3\uff0c\u6700\u5927\u9650\u5ea6\u5c07\u6709\u6548\u8f09\u8377\u905e\u9001\u81f3\u816b\u7624\u7d30\u80de\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002 \u5728OptiTROP-Lung05\u7814\u7a76\u4e2d\uff0c\u5171\u6709413\u4f8b\u60a3\u8005\u88ab\u96a8\u6a5f(1:1)\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u6cbb\u7642\u3002 \u65bc\u6578\u64da\u622a\u6b62\u6642\u9593(2025\u5e749\u670829\u65e5)\uff0c\u4e2d\u4f4d\u96a8\u8a2a10.5\u500b\u6708\uff0c\u7814\u7a76\u6578\u64da\u986f\u793a\uff1a \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u986f\u793a\u51fa\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u986f\u8457\u6539\u5584\u3002\u7531\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u5be9(BICR)\u8a55\u4f30\u7684\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(HR=0.35; 95% CI: 0.26-0.47; p&lt;0.0001)\uff0c12\u500b\u6708PFS\u7387\u70ba62.4% vs 29.0%\u3002 \u9810\u8a2d\u5404\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS\u226550%\u53caTPS 1-49%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.47 (95% CI: 0.29-0.77)\u548c0.28 (95% CI: 0.19-0.41)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002 \u00a0 \u7e3d\u751f\u5b58\u671f(OS)\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\uff1a\u4e2d\u4f4dOS\u5206\u5225\u70baNR vs 14.5\u500b\u6708(HR=0.55\uff1b95% CI: 0.36-0.85)\uff1b12\u500b\u6708OS\u7387\u70ba80.4% vs 68.9%\u3002 \u806f\u5408\u6cbb\u7642\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u7d44\u63d0\u9ad8\u4e86\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)(70.2% vs 42.0%)\u3001\u6df1\u5ea6\u7de9\u89e3\u7387(49.0% vs 25.9%) \u53ca12\u500b\u6708\u6301\u7e8c\u7de9\u89e3\u7387(77.7% vs 59.4%)\u3002 \u806f\u5408\u6cbb\u7642\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u66f4\u9ad8\uff0c\u4e3b\u8981\u662f\u7531\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u9810\u671f\u767c\u751f\u7684\u8840\u6db2\u5b78\u4e0d\u826f\u4e8b\u4ef6\u6240\u81f4\uff1b\u5169\u7d44\u56e0TEAEs\u5c0e\u81f4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u767c\u751f\u7387\u76f8\u4f3c\uff0c\u672a\u767c\u751f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u76f8\u95dc\u7684\u6b7b\u4ea1\uff1b\u7279\u5225\u95dc\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6(AEOSIs)\u8207\u5404\u8a66\u9a57\u85e5\u7269\u5df2\u77e5\u7684\u4e0d\u826f\u53cd\u61c9\u8b5c\u4e00\u81f4\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u671f\u4e2d\u5206\u6790\u7d50\u679c\u8868\u660e\uff0c\u76f8\u8f03\u65bc\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u5ef6\u9577PFS\u4e26\u964d\u4f4e\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\uff0c\u4e14\u9810\u8a2d\u7684\u5404\u4e9e\u7d44\u4e2d(\u5305\u62ecPD-L1\u8868\u9054\u6c34\u5e73\u3001\u7d44\u7e54\u5b78\u985e\u578b)\u5747\u8868\u73fe\u51fa\u4e00\u81f4\u7684PFS\u7372\u76ca\uff1b\u540c\u6642\u5df2\u89c0\u5bdf\u5230OS\u7684\u7372\u76ca\u8da8\u52e2\u3002\u806f\u5408\u6cbb\u7642\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u8207\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5\u5df2\u5efa\u7acb\u7684\u5b89\u5168\u6027\u7279\u5fb5\u4e00\u81f4\u3002 \u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0cOptiTROP\u2011Lung05\u7814\u7a76\u6210\u679c\u5df2\u540c\u6b65\u520a\u767b\u570b\u969b\u9802\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet, \u5f71\u97ff\u56e0\u5b50IF=88.5\uff09\uff0c\u8aaa\u660e\u5176\u81e8\u5e8a\u50f9\u503c\u8207\u5b78\u8853\u50f9\u503c\u5df2\u7372\u5f97\u570b\u969b\u4e00\u6d41\u5b78\u6703\u53ca\u6b0a\u5a01\u671f\u520a\u7684\u96d9\u91cd\u8a8d\u53ef\u3002 \u5168\u570b\u727d\u982d\u4e3b\u8981\u7814\u7a76\u8005\u3001\u540c\u6fdf\u5927\u5b78\u9644\u5c6c\u6771\u65b9\u91ab\u9662\u5468\u5f69\u5b58\u6559\u6388\u8868\u793a\uff1a\u300cOptiTROP-Lung05\u7814\u7a76\u53d6\u5f97\u7684\u7a4d\u6975\u7d50\u679c\u4ee4\u4eba\u632f\u596e\u3002\u4e0d\u50c5\u70ba\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\u5728\u80ba\u764c\u6cbb\u7642\u4e2d\u7684\u300e\u61c9\u7528\u524d\u79fb\u300f\u63d0\u4f9b\u4e86\u5faa\u8b49\u8b49\u64da\uff0c\u66f4\u7387\u5148\u9a57\u8b49\u4e86\u300eADC+IO\u300f\u5354\u540c\u7b56\u7565\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\u7684\u53ef\u884c\u6027\uff0c\u6709\u671b\u70ba\u5ee3\u5927\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u5168\u65b0\u7684\u751f\u5b58\u5e0c\u671b\u3002\u300d \u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp &amp; Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u8a3b\u518a\u5546\u6a19 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u77e5\u8b58\u7522\u6b0a\u7684\u65b0\u578bTROP2 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