{"id":439575,"date":"2026-05-27T19:00:00","date_gmt":"2026-05-27T11:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=439575"},"modified":"2026-05-27T19:00:00","modified_gmt":"2026-05-27T11:00:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a8easl-2026%e7%99%bc%e5%b8%83ensure-ii%e6%9c%9f%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e7%aa%81%e7%a0%b4%e6%80%a7%e6%95%b8%e6%93%9a%ef%bc%8c%e9%80%b2%e4%b8%80","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=439575","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u5728EASL 2026\u767c\u5e03ENSURE II\u671f\u7814\u7a76\u6700\u65b0\u7a81\u7834\u6027\u6578\u64da\uff0c\u9032\u4e00\u6b65\u652f\u6301BRII\u2011179\u5c0d\u5be6\u73fe\u4e59\u809d\u75c5\u6bd2\u6301\u4e45\u514d\u75ab\u5b78\u63a7\u5236\u7684\u6f5b\u5728\u4f5c\u7528"},"content":{"rendered":"<div>\n<ul type=\"disc\">\n<li><i>ENSURE\u7814\u7a76\u7684\u6700\u7d42\u7d50\u679c\u986f\u793a\uff0c\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG<\/i><i>\u2011<\/i><i>IFN\u03b1\uff09\u806f\u5408elebsiran\u6cbb\u7642\u76f8\u8f03\u65bc\u55ae\u7528PEG<\/i><i>\u2011<\/i><i>IFN\u03b1\u53ef\u5be6\u73fe\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387<\/i><\/li>\n<li><i>\u968a\u52174\u6578\u64da\u986f\u793a\uff0c\u65e2\u5f80\u5c0dBRII<\/i><i>\u2011<\/i><i>179\u6cbb\u7642\u7522\u751f\u61c9\u7b54\u7684\u53c3\u8207\u8005\u53d6\u5f97\u4e86\u6700\u70ba\u986f\u8457\u7684\u529f\u80fd\u6027\u6cbb\u6108\u6548\u679c\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5176\u6f5b\u5728\u7684\u81e8\u5e8a\u7372\u76ca<\/i><\/li>\n<li><i>\u4e00\u9805ENSURE\u8f49\u5316\u7814\u7a76\u7684\u6578\u64da\u8868\u660e\uff0cBRII<\/i><i>\u2011<\/i><i>179\u8a98\u5c0e\u7684\u8868\u4f4d\u932f\u914d\u7684CD4+ T\u7d30\u80de\u53ca\u5176\u4fc3\u6210\u7684HBs\u7279\u7570\u6027B\u7d30\u80de\u7684\u6210\u719f\uff0c\u8207\u6cbb\u6108\u6027\u7642\u6cd5\u5f8cHBsAg\u6e05\u9664\u7387\u7684\u63d0\u9ad8\u6709\u95dc\uff0c\u70ba\u5176\u6f5b\u5728\u4f5c\u7528\u6a5f\u5236\u63d0\u4f9b\u4e86\u65b0\u7684\u898b\u89e3<\/i><\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e02<\/span><span class=\"legendSpanClass\">2026\u5e745\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">\u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5728\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a3\u8209\u884c\u7684\u6b50\u6d32\u809d\u9ad2\u7814\u7a76\u5b78\u6703\uff08EASL\uff092026\u5e74\u5927\u6703\u4e0a\uff0c\u516c\u5e03\u4e86\u5176ENSURE II\u671f\u7814\u7a76\u968a\u52171-4\u7684\u6700\u7d42\u7814\u7a76\u7d50\u679c\u3002<\/p>\n<p>ENSURE\u7814\u7a76\uff08NCT05970289\uff09\u662f\u4e00\u9805\u5728\u4e9e\u592a\u5730\u5340\u958b\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3dII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u968a\u52171-3\u65e8\u5728\u8a55\u4f30\u7814\u7a76\u6027\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u85e5\u7269elebsiran\u5728\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\u4e2d\uff0c\u8207PEG\u2011IFN\u03b1\u806f\u5408\u6cbb\u7642\u6642\u7684\u7642\u6548\u8ca2\u737b\uff0c\u5165\u7d44\u53c3\u8207\u8005\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u57fa\u7dda\u6c34\u5e73\u70ba100\u20133,000 IU\/mL\u3002<\/p>\n<p>ENSURE\u7814\u7a76\u7684\u968a\u52174\u8a55\u4f30\u4e86\u4e00\u7a2e\u7528\u65bc\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u65b0\u578b\u5e8f\u8cab\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5229\u7528\u9a30\u76db\u535a\u85e5\u7684\u6cbb\u7642\u6027\u75ab\u82d7BRII\u2011179\u5c0d\u53c3\u8207\u8005\u9032\u884c\u514d\u75ab\u6fc0\u6d3b\u548c\u7be9\u9078\uff0c\u65e8\u5728\u63d0\u9ad8\u5176\u5c0d\u6cbb\u6108\u6027\u6cbb\u7642\u7684\u61c9\u7b54\u80fd\u529b\u3002\u8a72\u968a\u5217\u7d0d\u5165\u4e86\u5728\u65e2\u5f802\u671f\u7814\u7a76BRII\u2011179\u2011835\u2011001\uff08NCT04749368\uff09\u4e2d\u5b8c\u62109\u5291BRII\u2011179\u548celebsiran\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff0c\u4e26\u63a5\u53d7\u70ba\u671f48\u5468\u7684elebsiran\u8207PEG\u2011IFN\u03b1\u806f\u5408\u6cbb\u7642\u3002\u6839\u64da\u65e2\u5f80\u7814\u7a76\u4e2d\u4e59\u809d\u8868\u9762\u6297\u9ad4\uff08\u6297-HBs\uff09\u5cf0\u503c\u662f\u5426\u8d85\u904e10 IU\/L\uff0c\u53c3\u8207\u8005\u88ab\u5206\u70baBRII\u2011179\u6297\u2011HBs\u61c9\u7b54\u8005\u548c\u7121\u61c9\u7b54\u8005\u3002<\/p>\n<p>\u6240\u6709\u53c3\u8207\u8005\u5728\u5b8c\u6210PEG\u2011IFN\u03b1\u806f\u5408elebsiran\u6cbb\u7642\u5f8c\uff0c\u5747\u7e7c\u7e8c\u63a5\u53d7\u6838\u7518\uff08\u9178\uff09\u985e\u4f3c\u7269\uff08NA\uff09\u978f\u56fa\u6cbb\u764224\u5468\u3002\u672c\u6b21\u767c\u5e03\u4e86ENSURE\u7814\u7a76\u7d50\u675f\u6642\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u5176\u5b9a\u7fa9\u70ba\u5728\u505c\u6b62\u5305\u62ecNA\u5728\u5167\u7684\u6240\u6709\u6cbb\u7642\u5f8c\u81f3\u5c1124\u5468\uff0c\u5be6\u73fe\u6301\u7e8c\u7684HBsAg\u6e05\u9664\u4e14HBV DNA\u672a\u6aa2\u51fa\u3002\u6700\u7d42\u7d50\u679c\u986f\u793a\uff0c\u5728elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u6cbb\u7642\u968a\u5217\u4e2d\u89c0\u5bdf\u5230\u7684HBsAg\u6e05\u9664\u7372\u76ca\uff0c\u8f49\u5316\u70ba\u8f03PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002\u65e2\u5f80\u63a5\u53d7BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff0c\u5c24\u5176\u662f\u6297\u2011HBs\u61c9\u7b54\u8005\uff0c\u53d6\u5f97\u4e86\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u63d0\u793aBRII\u2011179\u53ef\u80fd\u5728\u5be6\u73fe\u5c0dHBV\u6301\u4e45\u514d\u75ab\u5b78\u63a7\u5236\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p>\u9a30\u76db\u535a\u85e5\u6b63\u5728\u958b\u5c55\u53e6\u5916\u5169\u98052b\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u4ee5\u9032\u4e00\u6b65\u660e\u78baBRII\u2011179\u5728\u6162\u6027\u4e59\u578b\u809d\u708e\u6cbb\u7642\u4e2d\u7684\u4f5c\u7528\uff0c\u4e26\u70ba\u95dc\u9375\u6027\u7814\u7a76\u512a\u5316\u806f\u5408\u6cbb\u7642\u65b9\u6848\u3002\u5176\u4e2d\uff0cENRICH\u7814\u7a76\u65e8\u5728\u8a55\u4f30BRII\u2011179\u5728\u6fc0\u6d3bHBV\u7279\u7570\u6027\u514d\u75ab\u53cd\u61c9\u4e2d\u7684\u4f5c\u7528\uff0c\u4e26\u8b58\u5225\u66f4\u6709\u53ef\u80fd\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u6108\u7684\u514d\u75ab\u61c9\u7b54\u4eba\u7fa4\u3002ENHANCE\u7814\u7a76\u5305\u62ec\u5169\u500b\u90e8\u5206\uff1a\u4e00\u90e8\u5206\u8a55\u4f30BRII\u2011179\u3001elebsiran\u8207PEG\u2011IFN\u03b1\u70ba\u671f48\u5468\u7684\u540c\u6b65\u4e09\u806f\u6cbb\u7642\u65b9\u6848\uff1b\u53e6\u4e00\u90e8\u5206\u8a55\u4f30\u5148\u884c24\u5468BRII\u2011179\u806f\u5408elebsiran\u6cbb\u7642\uff0c\u96a8\u5f8c\u518d\u9032\u884c24\u5468\u4e09\u806f\u6cbb\u7642\u7684\u5e8f\u8cab\u65b9\u6848\u3002\u5169\u9805\u7814\u7a76\u7684\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u6578\u64da\u9810\u8a08\u5c07\u65bc2026\u5e74\u516c\u5e03\u3002<\/p>\n<p>\u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5c0dENSURE\u7814\u7a76\u4e2d\u6301\u7e8c\u89c0\u5bdf\u5230\u4e00\u81f4\u6027\u7684\u7814\u7a76\u7d50\u679c\u611f\u5230\u9f13\u821e\uff0c\u76f8\u4fe1\u672c\u6b21\u767c\u5e03\u7684\u6700\u7d42\u7d50\u679c\u51f8\u986f\u4e86BRII\u2011179\u548celebsiran\u5728\u63d0\u5347\u529f\u80fd\u6027\u6cbb\u6108\u7d50\u5c40\u65b9\u9762\u7684\u6f5b\u529b\u3002ENSURE\u7684\u7814\u7a76\u7d50\u679c\uff0c\u7d50\u5408\u6211\u5011\u5f8c\u7e8c\u5373\u5c07\u62ab\u9732\u7684\u5728\u7814\u8a66\u9a57\u6578\u64da\uff0c\u5c07\u70ba\u516c\u53f8\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\u9805\u76ee\u7684\u672a\u4f86\u958b\u767c\u8a08\u5283\u63d0\u4f9b\u95dc\u9375\u4f9d\u64da\u3002\u300d<\/p>\n<p>\u6700\u65b0\u7a81\u7834\u6027\u58c1\u5831\u5c55\u793a\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a<br \/><b>\u6a19\u984c\uff1a<\/b>\u63a5\u53d7elebsiran\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u7684\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u53c3\u8207\u8005\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff1aENSURE II\u671f\u7814\u7a76\u6700\u7d42\u7d50\u679c<br \/><b>\u6703\u8b70\/\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u6700\u65b0\u7a81\u7834\u6027\u58c1\u5831\uff08Late\u2011Breaker Poster\uff09<br \/><b>\u5c55\u793a\u65e5\u671f\u548c\u6642\u9593\uff1a<\/b>5\u670827\u65e58:30\u81f35\u670830\u65e5 16:00\uff08UTC+2\uff09<br \/><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>LB26\u20115012 \/ LBP\u2011040<br \/><b>\u5831\u544a\u4eba\uff1a<\/b>\u9ec3\u9e97\u8679\u6559\u6388\uff0cMBChB (CUHK), MD (CUHK), FRCP (Lond, Edin), FHKCP, FHKAM (Medicine)\uff0c\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u6578\u64da\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u5167\u79d1\u5b78\u8207\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u80c3\u8178\u75c5\u5b78\u53ca\u809d\u75c5\u5b78\u6559\u6388<\/p>\n<ul type=\"disc\">\n<li>\u5728\u7b2c72\u5468\uff08\u6cbb\u7642\u7d50\u675fEOT\u5f8c24\u5468\uff09\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u768420\u4f8b\u53c3\u8207\u8005\u4e2d\u670919\u4f8b\u7b26\u5408NA\u505c\u85e5\u6a19\u51c6\uff0c\u4e26\u9032\u5165\u984d\u5916\u768424\u5468\u96a8\u8a2a\u671f\uff1b\u53e61\u4f8b\u53c3\u8207\u8005\u4ecd\u70baHBeAg\u967d\u6027\u3002<\/li>\n<li>\u5728\u968a\u52171-3\u4e2d\uff0celebsiran 200 mg\u6216100 mg\u806f\u5408PEG\u2011IFN\u03b1\u6cbb\u7642\u968a\u5217\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u5206\u5225\u70ba2\/19\uff0810.5%\uff09\u548c3\/18\uff0816.7%\uff09\uff0c\u9ad8\u65bcPEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u968a\u5217\u76841\/18\uff085.6%\uff09\u3002\u5728\u968a\u52174\u4e2d\uff0c8\/31\uff0825.8%\uff09\u4f8b\u53c3\u8207\u8005\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u6108\uff0c\u5176\u4e2d\u6297\u2011HBs\u61c9\u7b54\u8005\u70ba7\/19\uff0836.8%\uff09\uff0c\u660e\u986f\u9ad8\u65bc\u975e\u61c9\u7b54\u8005\u76841\/12\uff088.3%\uff09\u3002<\/li>\n<li>\u76e1\u7ba1\u6240\u6709\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u6108\u7684\u53c3\u8207\u8005\u5728ENSURE\u7814\u7a76\u4e2d\u7684HBsAg\u57fa\u7dda\u6c34\u5e73\u5747\u4f4e\u65bc1,000 IU\/mL\uff0c\u4f467\u4f8b\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u6108\u7684\u6297\u2011HBs\u61c9\u7b54\u8005\u4e2d\u67094\u4f8b\uff0857.1%\uff09\u5728\u53c3\u52a0\u65e2\u5f80BRII-179-835-001\u7814\u7a76\u524d\u7684HBsAg\u57fa\u7dda\u6c34\u5e73\u4ecb\u65bc1,154-3,086 IU\/mL\u4e4b\u9593\u3002<\/li>\n<li>\u5728\u505c\u7528NA\u6cbb\u7642\u5f8c\uff0c\u672a\u5831\u544a\u65b0\u7684\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u4e14\u5927\u591a\u6578TRAE\u5728EOT\u5f8c\u96a8\u8a2a\u671f\u9593\u7de9\u89e3\u3002<\/li>\n<li>\u901a\u904e\u806f\u5408\u6cbb\u7642\u5be6\u73fe\u6301\u7e8cHBsAg\u6e05\u9664\u7684\u53c3\u8207\u8005\uff0c\u5728\u505c\u7528NA\u5f8c\u8868\u73fe\u51fa\u826f\u597d\u7684\u81e8\u5e8a\u7d50\u5c40\uff0c\u5305\u62ecHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8c37\u4e19\u8f49\u6c28\u9176\uff08ALT\uff09\u5347\u9ad8\u3002<\/li>\n<\/ul>\n<p>\u5728\u53e6\u4e00\u9805\u53e3\u982d\u5831\u544a\u4e2d\uff0cNina Le Bert\u535a\u58eb\u5c07\u532f\u5831\u4e00\u9805\u8f49\u5316\u7814\u7a76\u7684\u7d50\u679c\u3002\u8a72\u7814\u7a76\u5229\u7528\u4f86\u81eaENSURE\u53ca\u6b64\u524dBRII-179-835-001\u8a66\u9a57\u7684\u6a23\u672c\uff0c\u8a55\u4f30\u4e86\u8207BRII-179\u76f8\u95dc\u7684\u514d\u75ab\u53cd\u61c9\u3002\u8a72\u7814\u7a76\u767c\u73fe\u4e86\u4e00\u7a2e\u65b0\u578b\u6a5f\u5236\uff1aBRII-179\u53ef\u8a98\u5c0e\u91dd\u5c0dPre-S1\u5340\u57df\u4e2d\u8207\u5faa\u74b0\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u57fa\u56e0\u578b\u4e0d\u5339\u914d\u7684\u8868\u4f4d\u5e8f\u5217\u7684CD4+ T\u7d30\u80de\u61c9\u7b54\u3002\u9019\u4e9b\u75ab\u82d7\u8a98\u5c0e\u7684T\u7d30\u80de\u5728\u5169\u5e74\u591a\u6642\u9593\u5167\u4fdd\u6301\u529f\u80fd\u7a69\u5b9a\uff0c\u4e26\u5728\u96a8\u5f8c\u7684PEG-IFN\u03b1\u548csiRNA\u6cbb\u7642\u671f\u9593\u6301\u7e8c\u5b58\u5728\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u9019\u4e9bT\u7d30\u80de\u61c9\u7b54\u8207\u6cbb\u7642\u671f\u9593HBs\u7279\u7570\u6027B\u7d30\u80de\u7684\u6f38\u9032\u6027\u6210\u719f\u76f8\u95dc\uff0c\u9019\u4e00\u6548\u61c9\u8207HBsAg\u6e05\u9664\u7387\u7684\u63d0\u9ad8\u76f8\u95dc\u3002\u9019\u4e9b\u767c\u73fe\u70baBRII-179\u4ecb\u5c0e\u7684\u529f\u80fd\u6027\u6cbb\u6108\u6f5b\u5728\u6a5f\u5236\u63d0\u4f9b\u4e86\u65b0\u7684\u898b\u89e3\u3002<\/p>\n<p>\u6709\u95dc\u9a30\u76db\u535a\u85e5\u4e59\u809d\u5019\u9078\u85e5\u7269\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\uff1a<a href=\"http:\/\/www.briibio.com\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.briibio.com<\/a>\u3002<\/p>\n<p><b>\u95dc\u65bc\u4e59\u578b\u809d\u708e<\/b><\/p>\n<p>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002<sup>[1]<\/sup>\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u9ad2\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4e26\u767c\u75c7\u3002<sup>1<\/sup>\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002<sup>[2]<\/sup><\/p>\n<p><b>\u95dc\u65bcBRII-179<\/b><\/p>\n<p>BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bcElebsiran<\/b><\/p>\n<p>Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV 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\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bc\u9a30\u76db\u535a\u85e5<\/b><\/p>\n<p>\u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.briibio.com<\/a>\u3002<\/p>\n<p><sup>[1]<\/sup> World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from <a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789240091672\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/a><\/p>\n<p><sup>[2]<\/sup> World Health Organization. Hepatitis. World Health Organization. Retrieved from <a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a><a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">.<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>ENSURE\u7814\u7a76\u7684\u6700\u7d42\u7d50\u679c\u986f\u793a&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-439575","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u9a30\u76db\u535a\u85e5\u5728EASL 2026\u767c\u5e03ENSURE II\u671f\u7814\u7a76\u6700\u65b0\u7a81\u7834\u6027\u6578\u64da\uff0c\u9032\u4e00\u6b65\u652f\u6301BRII\u2011179\u5c0d\u5be6\u73fe\u4e59\u809d\u75c5\u6bd2\u6301\u4e45\u514d\u75ab\u5b78\u63a7\u5236\u7684\u6f5b\u5728\u4f5c\u7528 - 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ENSURE\u7814\u7a76\uff08NCT05970289\uff09\u662f\u4e00\u9805\u5728\u4e9e\u592a\u5730\u5340\u958b\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3dII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u968a\u52171-3\u65e8\u5728\u8a55\u4f30\u7814\u7a76\u6027\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u85e5\u7269elebsiran\u5728\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\u4e2d\uff0c\u8207PEG\u2011IFN\u03b1\u806f\u5408\u6cbb\u7642\u6642\u7684\u7642\u6548\u8ca2\u737b\uff0c\u5165\u7d44\u53c3\u8207\u8005\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u57fa\u7dda\u6c34\u5e73\u70ba100\u20133,000 IU\/mL\u3002 ENSURE\u7814\u7a76\u7684\u968a\u52174\u8a55\u4f30\u4e86\u4e00\u7a2e\u7528\u65bc\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u65b0\u578b\u5e8f\u8cab\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5229\u7528\u9a30\u76db\u535a\u85e5\u7684\u6cbb\u7642\u6027\u75ab\u82d7BRII\u2011179\u5c0d\u53c3\u8207\u8005\u9032\u884c\u514d\u75ab\u6fc0\u6d3b\u548c\u7be9\u9078\uff0c\u65e8\u5728\u63d0\u9ad8\u5176\u5c0d\u6cbb\u6108\u6027\u6cbb\u7642\u7684\u61c9\u7b54\u80fd\u529b\u3002\u8a72\u968a\u5217\u7d0d\u5165\u4e86\u5728\u65e2\u5f802\u671f\u7814\u7a76BRII\u2011179\u2011835\u2011001\uff08NCT04749368\uff09\u4e2d\u5b8c\u62109\u5291BRII\u2011179\u548celebsiran\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff0c\u4e26\u63a5\u53d7\u70ba\u671f48\u5468\u7684elebsiran\u8207PEG\u2011IFN\u03b1\u806f\u5408\u6cbb\u7642\u3002\u6839\u64da\u65e2\u5f80\u7814\u7a76\u4e2d\u4e59\u809d\u8868\u9762\u6297\u9ad4\uff08\u6297-HBs\uff09\u5cf0\u503c\u662f\u5426\u8d85\u904e10 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DNA\u672a\u6aa2\u51fa\u3002\u6700\u7d42\u7d50\u679c\u986f\u793a\uff0c\u5728elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u6cbb\u7642\u968a\u5217\u4e2d\u89c0\u5bdf\u5230\u7684HBsAg\u6e05\u9664\u7372\u76ca\uff0c\u8f49\u5316\u70ba\u8f03PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002\u65e2\u5f80\u63a5\u53d7BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff0c\u5c24\u5176\u662f\u6297\u2011HBs\u61c9\u7b54\u8005\uff0c\u53d6\u5f97\u4e86\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u63d0\u793aBRII\u2011179\u53ef\u80fd\u5728\u5be6\u73fe\u5c0dHBV\u6301\u4e45\u514d\u75ab\u5b78\u63a7\u5236\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002 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\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002  World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672  World Health Organization. Hepatitis. World Health Organization. Retrieved from https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=439575\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9a30\u76db\u535a\u85e5\u5728EASL 2026\u767c\u5e03ENSURE II\u671f\u7814\u7a76\u6700\u65b0\u7a81\u7834\u6027\u6578\u64da\uff0c\u9032\u4e00\u6b65\u652f\u6301BRII\u2011179\u5c0d\u5be6\u73fe\u4e59\u809d\u75c5\u6bd2\u6301\u4e45\u514d\u75ab\u5b78\u63a7\u5236\u7684\u6f5b\u5728\u4f5c\u7528 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" 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\u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002  World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672  World Health Organization. Hepatitis. World Health Organization. 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(April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672  World Health Organization. Hepatitis. World Health Organization. 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ENSURE\u7814\u7a76\u7684\u968a\u52174\u8a55\u4f30\u4e86\u4e00\u7a2e\u7528\u65bc\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u65b0\u578b\u5e8f\u8cab\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5229\u7528\u9a30\u76db\u535a\u85e5\u7684\u6cbb\u7642\u6027\u75ab\u82d7BRII\u2011179\u5c0d\u53c3\u8207\u8005\u9032\u884c\u514d\u75ab\u6fc0\u6d3b\u548c\u7be9\u9078\uff0c\u65e8\u5728\u63d0\u9ad8\u5176\u5c0d\u6cbb\u6108\u6027\u6cbb\u7642\u7684\u61c9\u7b54\u80fd\u529b\u3002\u8a72\u968a\u5217\u7d0d\u5165\u4e86\u5728\u65e2\u5f802\u671f\u7814\u7a76BRII\u2011179\u2011835\u2011001\uff08NCT04749368\uff09\u4e2d\u5b8c\u62109\u5291BRII\u2011179\u548celebsiran\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff0c\u4e26\u63a5\u53d7\u70ba\u671f48\u5468\u7684elebsiran\u8207PEG\u2011IFN\u03b1\u806f\u5408\u6cbb\u7642\u3002\u6839\u64da\u65e2\u5f80\u7814\u7a76\u4e2d\u4e59\u809d\u8868\u9762\u6297\u9ad4\uff08\u6297-HBs\uff09\u5cf0\u503c\u662f\u5426\u8d85\u904e10 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DNA\u672a\u6aa2\u51fa\u3002\u6700\u7d42\u7d50\u679c\u986f\u793a\uff0c\u5728elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u6cbb\u7642\u968a\u5217\u4e2d\u89c0\u5bdf\u5230\u7684HBsAg\u6e05\u9664\u7372\u76ca\uff0c\u8f49\u5316\u70ba\u8f03PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\u3002\u65e2\u5f80\u63a5\u53d7BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff0c\u5c24\u5176\u662f\u6297\u2011HBs\u61c9\u7b54\u8005\uff0c\u53d6\u5f97\u4e86\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u6108\u7387\uff0c\u63d0\u793aBRII\u2011179\u53ef\u80fd\u5728\u5be6\u73fe\u5c0dHBV\u6301\u4e45\u514d\u75ab\u5b78\u63a7\u5236\u4e2d\u767c\u63ee\u91cd\u8981\u4f5c\u7528\u3002 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(April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672  World Health Organization. Hepatitis. World Health Organization. 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(April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from https:\/\/www.who.int\/publications\/i\/item\/9789240091672 World Health Organization. Hepatitis. World Health Organization. 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