{"id":437820,"date":"2026-05-22T10:40:00","date_gmt":"2026-05-22T02:40:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=437820"},"modified":"2026-05-22T10:40:00","modified_gmt":"2026-05-22T02:40:00","slug":"%e3%80%902026-asco%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5%e5%85%ac%e4%bd%88%e5%a4%9a%e9%a0%85%e8%87%a8%e5%ba%8a%e9%80%b2%e5%b1%95%ef%bc%8c%e4%b8%89%e9%a0%85%e7%8d%b2%e5%bf%ab%e9%80%9f%e5%8f%a3","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=437820","title":{"rendered":"\u30102026 ASCO\u3011\u4e9e\u76db\u91ab\u85e5\u516c\u4f48\u591a\u9805\u81e8\u5e8a\u9032\u5c55\uff0c\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2026\u5e745\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u516d\u9805\u5165\u90782026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u6458\u8981\u5df2\u65bcASCO\u5b98\u7db2\u516c\u4f48\u3002\u6b64\u6b21\u5165\u9078\u7684\u7814\u7a76\u4e2d\uff0c\u6709\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a\u3001\u4e09\u9805\u7372\u58c1\u5831\u5c55\u793a\uff0c\u6d89\u53ca\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\u3001\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5<sup>\u00ae<\/sup>\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u4e09\u500b\u91cd\u9ede\u54c1\u7a2e\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u672c\u5c46ASCO\u5e74\u6703\u5c07\u65bc5\u670829\u65e5\u81f36\u67082\u65e5\uff08\u7f8e\u570b\u7576\u5730\u6642\u9593\uff09\u5728\u829d\u52a0\u54e5McCormick\u6703\u8b70\u4e2d\u5fc3\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u7d50\u5408\u7684\u5f62\u5f0f\u8209\u8fa6\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u3001\u6700\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002<\/p>\n<p>\u4e9e\u76db\u91ab\u85e5\u5165\u90782026ASCO\u5e74\u6703\u7684\u6458\u8981\u6838\u5fc3\u4fe1\u606f\u5982\u4e0b\uff1a<br \/><b><u>\u5feb\u901f\u53e3\u982d\u5831\u544a<br \/><\/u><\/b><b>Olverembatinib (HQP1351) combined with blinatumomab in patients with lymphoid blast phase chronic myeloid leukemia (CML-LBP) or Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL)<br \/><\/b><b>\u5967\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>HQP1351<\/b><b>\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08<\/b><b>CML-LBP<\/b><b>\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027<\/b><b>B<\/b><b>\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08<\/b><b>Ph+ BCP-ALL<\/b><b>\uff09\u60a3\u8005<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>6513<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u5feb\u901f\u53e3\u982d\u5831\u544a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09<br \/><b>\u5831\u544a\u6642\u9593\uff1a<\/b><br \/>2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff09<br \/>2026\u5e745\u670831\u65e5 \u51cc\u66682:51 &#8211; 2:57\uff08\u5317\u4eac\u6642\u9593\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>Elias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a <\/b><\/p>\n<ul type=\"disc\">\n<li>\u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002<\/li>\n<li>\u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002<\/li>\n<li>\u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002<\/li>\n<\/ul>\n<p><b>Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)<br \/><\/b><b>\u5967\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>HQP1351<\/b><b>\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08<\/b><b>CP-CML<\/b><b>\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>6510<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u5feb\u901f\u53e3\u982d\u5831\u544a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09<br \/><b>\u5831\u544a\u6642\u9593\uff1a<\/b><br \/>2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff09<br \/>2026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a <\/b><\/p>\n<ul type=\"disc\">\n<li>\u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002<\/li>\n<li>\u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002<\/li>\n<li>\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002<\/li>\n<\/ul>\n<p><b>Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)<br \/><\/b><b>Alrizomadlin<\/b><b>\uff08<\/b><b>APG-115<\/b><b>\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08<\/b><b>APG-2575<\/b><b>\uff09\u6cbb\u7642\u5fa9\u767c<\/b><b>\/<\/b><b>\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08<\/b><b>RMS<\/b><b>\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08<\/b><b>STSs<\/b><b>\uff09\u5152\u7ae5\u60a3\u8005<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>10012<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u5feb\u901f\u53e3\u982d\u5831\u544a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09<br \/><b>\u5831\u544a\u6642\u9593\uff1a<\/b><br \/>2026\u5e745\u670830\u65e5 8:00 &#8211; 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff09<br \/>2026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a <\/b><\/p>\n<ul type=\"disc\">\n<li>\u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002<\/li>\n<li>\u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002<\/li>\n<li>\u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b><u>\u58c1\u5831\u5c55\u793a<br \/><\/u><\/b><b>Updated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors<br \/><\/b><b>\u5967\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>HQP1351<\/b><b>\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08<\/b><b>SDH-<\/b><b>\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>11539<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u5831\u5c55\u793a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u8089\u7624\uff08Sarcoma\uff09<br \/><b>\u5831\u544a\u6642\u9593\uff1a<\/b><br \/>2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff09<br \/>2026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a <\/b><\/p>\n<ul type=\"disc\">\n<li>\u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002<\/li>\n<li>\u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002<\/li>\n<li>\u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002<\/li>\n<\/ul>\n<p><b>A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress<br \/><\/b><b>\u5967\u96f7\u5df4\u66ff\u5c3c\uff08<\/b><b>HQP1351<\/b><b>\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684<\/b><b>III<\/b><b>\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684<\/b><b>POLARIS-2<\/b><b>\u8a66\u9a57<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>TPS6608<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u5831\u5c55\u793a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09<br \/><b>\u5831\u544a\u6642\u9593\uff1a<\/b><br \/>2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff09<br \/>2026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>Elias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a <\/b><\/p>\n<ul type=\"disc\">\n<li>POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002<\/li>\n<li>\u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002<\/li>\n<\/ul>\n<p><b>A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): GLORA trial in progress<br \/><\/b><b>\u5229\u6c99\u6258\u514b\u62c9\uff08<\/b><b>APG-2575<\/b><b>\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5<\/b><b>\/<\/b><b>\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08<\/b><b>CLL\/SLL<\/b><b>\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001<\/b><b>III<\/b><b>\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684<\/b><b>GLORA<\/b><b>\u8a66\u9a57<br \/><\/b><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>TPS7101<br \/><b>\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u5831\u5c55\u793a<br \/><b>\u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09<br \/><b>\u5831\u544a\u6642\u9593\uff1a<\/b><br \/>2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff09<br \/>2026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09<br \/><b>\u7b2c\u4e00\u4f5c\u8005\uff1a<\/b>Matthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662<br \/><b>\u6838\u5fc3\u8981\u9ede\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002<\/li>\n<li>\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 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\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u516d\u9805\u5165\u90782026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u6458\u8981\u5df2\u65bcASCO\u5b98\u7db2\u516c\u4f48\u3002\u6b64\u6b21\u5165\u9078\u7684\u7814\u7a76\u4e2d\uff0c\u6709\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a\u3001\u4e09\u9805\u7372\u58c1\u5831\u5c55\u793a\uff0c\u6d89\u53ca\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5\u00ae\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u4e09\u500b\u91cd\u9ede\u54c1\u7a2e\u3002     \u672c\u5c46ASCO\u5e74\u6703\u5c07\u65bc5\u670829\u65e5\u81f36\u67082\u65e5\uff08\u7f8e\u570b\u7576\u5730\u6642\u9593\uff09\u5728\u829d\u52a0\u54e5McCormick\u6703\u8b70\u4e2d\u5fc3\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u7d50\u5408\u7684\u5f62\u5f0f\u8209\u8fa6\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u3001\u6700\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002 \u4e9e\u76db\u91ab\u85e5\u5165\u90782026ASCO\u5e74\u6703\u7684\u6458\u8981\u6838\u5fc3\u4fe1\u606f\u5982\u4e0b\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544aOlverembatinib (HQP1351) combined with blinatumomab in patients with lymphoid blast phase chronic myeloid leukemia (CML-LBP) or Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML-LBP\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027B\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ BCP-ALL\uff09\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a6513\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:51 - 2:57\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002  \u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002  \u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002  Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP-CML\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u6458\u8981\u7de8\u865f\uff1a6510\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002  \u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002  \u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002  Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 8:00 - 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002  \u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002  \u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002  \u58c1\u5831\u5c55\u793aUpdated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c\u6458\u8981\u7de8\u865f\uff1a11539\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8089\u7624\uff08Sarcoma\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002  \u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002  \u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002  A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684POLARIS-2\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS6608\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002  A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): GLORA trial in progress\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684GLORA\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS7101\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMatthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u6838\u5fc3\u8981\u9ede\uff1a   GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 \u500b\u570b\u5bb6 126 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ALL\uff09\u60a3\u8005POLARIS-1\u7814\u7a76\uff1b\u7372\u7f8e\u570bFDA\u548c\u6b50\u6d32EMA\u8a31\u53ef\u7684\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u7d93\u6cbbCML-CP\u6210\u5e74\u60a3\u8005\u7684POLARIS-2\u7814\u7a76\uff1b\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH-\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684POLARIS-3\u7814\u7a76\u3002 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\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u963f\u65af\u5229\u5eb7\u3001\u9ed8\u6c99\u6771\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u773e\u591a\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u9054\u6210\u5168\u7403\u5408\u4f5c\uff0c\u540c\u6642\u8207\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u3001\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u5efa\u7acb\u7814\u767c\u5408\u4f5c\u95dc\u4fc2\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f https:\/\/ascentage.com\/ \u524d\u77bb\u6027\u8072\u660e\u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 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content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u30102026 ASCO\u3011\u4e9e\u76db\u91ab\u85e5\u516c\u4f48\u591a\u9805\u81e8\u5e8a\u9032\u5c55\uff0c\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e745\u670822\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u516d\u9805\u5165\u90782026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u6458\u8981\u5df2\u65bcASCO\u5b98\u7db2\u516c\u4f48\u3002\u6b64\u6b21\u5165\u9078\u7684\u7814\u7a76\u4e2d\uff0c\u6709\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a\u3001\u4e09\u9805\u7372\u58c1\u5831\u5c55\u793a\uff0c\u6d89\u53ca\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5\u00ae\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u4e09\u500b\u91cd\u9ede\u54c1\u7a2e\u3002     \u672c\u5c46ASCO\u5e74\u6703\u5c07\u65bc5\u670829\u65e5\u81f36\u67082\u65e5\uff08\u7f8e\u570b\u7576\u5730\u6642\u9593\uff09\u5728\u829d\u52a0\u54e5McCormick\u6703\u8b70\u4e2d\u5fc3\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u7d50\u5408\u7684\u5f62\u5f0f\u8209\u8fa6\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u3001\u6700\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002 \u4e9e\u76db\u91ab\u85e5\u5165\u90782026ASCO\u5e74\u6703\u7684\u6458\u8981\u6838\u5fc3\u4fe1\u606f\u5982\u4e0b\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544aOlverembatinib (HQP1351) combined with blinatumomab in patients with lymphoid blast phase chronic myeloid leukemia (CML-LBP) or Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML-LBP\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027B\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ BCP-ALL\uff09\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a6513\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:51 - 2:57\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002  \u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002  \u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002  Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP-CML\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u6458\u8981\u7de8\u865f\uff1a6510\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002  \u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002  \u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002  Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 8:00 - 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002  \u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002  \u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002  \u58c1\u5831\u5c55\u793aUpdated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c\u6458\u8981\u7de8\u865f\uff1a11539\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8089\u7624\uff08Sarcoma\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002  \u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002  \u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002  A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684POLARIS-2\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS6608\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002  A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): GLORA trial in progress\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684GLORA\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS7101\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMatthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u6838\u5fc3\u8981\u9ede\uff1a   GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 \u500b\u570b\u5bb6 126 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BCP-ALL)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML-LBP\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027B\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ BCP-ALL\uff09\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a6513\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:51 - 2:57\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\\\/\u96e3\u6cbb\uff08R\\\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002 \u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002 \u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\\\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP-CML\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u6458\u8981\u7de8\u865f\uff1a6510\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002 \u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002 \u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\\\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002 Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\\\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\\\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 8:00 - 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\\\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002 \u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002 \u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002 \u58c1\u5831\u5c55\u793aUpdated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c\u6458\u8981\u7de8\u865f\uff1a11539\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8089\u7624\uff08Sarcoma\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002 \u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002 A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684POLARIS-2\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS6608\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002 \u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002 A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\\\/small lymphocytic lymphoma (CLL\\\/SLL): GLORA trial in progress\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684GLORA\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS7101\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMatthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u6838\u5fc3\u8981\u9ede\uff1a GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002 \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\\\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 \u500b\u570b\u5bb6 126 \u500b\u4e2d\u5fc3\u958b\u5c55\uff0c\u76ee\u524d\u6b63\u5728\u62db\u52df\u4e2d\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u516c\u53f8\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\u3001\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u4ee5\u53ca\u86cb\u767d\u964d\u89e3\u5291\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u6cbb\u7642\u4f34\u6709T315I\u7a81\u8b8a\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u548c\u52a0\u901f\u671f\uff08CML-AP\uff09\u60a3\u8005\uff0c\u4ee5\u53ca\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\\\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\u3002\u8a72\u85e5\u7269\u6240\u6709\u7372\u6279\u9069\u61c9\u75c7\u5747\u5df2\u88ab\u7d0d\u5165\u4e2d\u570b\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff08NRDL\uff09\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e09\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\uff1a\u7372\u7f8e\u570bFDA\u548c\u6b50\u6d32EMA\u8a31\u53ef\u7684\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ 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\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u516d\u9805\u5165\u90782026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u6458\u8981\u5df2\u65bcASCO\u5b98\u7db2\u516c\u4f48\u3002\u6b64\u6b21\u5165\u9078\u7684\u7814\u7a76\u4e2d\uff0c\u6709\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a\u3001\u4e09\u9805\u7372\u58c1\u5831\u5c55\u793a\uff0c\u6d89\u53ca\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5\u00ae\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u4e09\u500b\u91cd\u9ede\u54c1\u7a2e\u3002     \u672c\u5c46ASCO\u5e74\u6703\u5c07\u65bc5\u670829\u65e5\u81f36\u67082\u65e5\uff08\u7f8e\u570b\u7576\u5730\u6642\u9593\uff09\u5728\u829d\u52a0\u54e5McCormick\u6703\u8b70\u4e2d\u5fc3\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u7d50\u5408\u7684\u5f62\u5f0f\u8209\u8fa6\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u3001\u6700\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002 \u4e9e\u76db\u91ab\u85e5\u5165\u90782026ASCO\u5e74\u6703\u7684\u6458\u8981\u6838\u5fc3\u4fe1\u606f\u5982\u4e0b\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544aOlverembatinib (HQP1351) combined with blinatumomab in patients with lymphoid blast phase chronic myeloid leukemia (CML-LBP) or Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML-LBP\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027B\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ BCP-ALL\uff09\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a6513\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:51 - 2:57\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002  \u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002  \u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002  Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP-CML\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u6458\u8981\u7de8\u865f\uff1a6510\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002  \u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002  \u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002  Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 8:00 - 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002  \u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002  \u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002  \u58c1\u5831\u5c55\u793aUpdated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c\u6458\u8981\u7de8\u865f\uff1a11539\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8089\u7624\uff08Sarcoma\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002  \u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002  \u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002  A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684POLARIS-2\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS6608\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002  A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): GLORA trial in progress\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684GLORA\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS7101\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMatthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u6838\u5fc3\u8981\u9ede\uff1a   GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 \u500b\u570b\u5bb6 126 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ALL\uff09\u60a3\u8005POLARIS-1\u7814\u7a76\uff1b\u7372\u7f8e\u570bFDA\u548c\u6b50\u6d32EMA\u8a31\u53ef\u7684\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u7d93\u6cbbCML-CP\u6210\u5e74\u60a3\u8005\u7684POLARIS-2\u7814\u7a76\uff1b\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH-\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684POLARIS-3\u7814\u7a76\u3002 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ASCO\u3011\u4e9e\u76db\u91ab\u85e5\u516c\u4f48\u591a\u9805\u81e8\u5e8a\u9032\u5c55\uff0c\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e745\u670822\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u516d\u9805\u5165\u90782026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u6458\u8981\u5df2\u65bcASCO\u5b98\u7db2\u516c\u4f48\u3002\u6b64\u6b21\u5165\u9078\u7684\u7814\u7a76\u4e2d\uff0c\u6709\u4e09\u9805\u7372\u5feb\u901f\u53e3\u982d\u5831\u544a\u3001\u4e09\u9805\u7372\u58c1\u5831\u5c55\u793a\uff0c\u6d89\u53ca\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u3001\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5\u00ae\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u4e09\u500b\u91cd\u9ede\u54c1\u7a2e\u3002     \u672c\u5c46ASCO\u5e74\u6703\u5c07\u65bc5\u670829\u65e5\u81f36\u67082\u65e5\uff08\u7f8e\u570b\u7576\u5730\u6642\u9593\uff09\u5728\u829d\u52a0\u54e5McCormick\u6703\u8b70\u4e2d\u5fc3\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u7d50\u5408\u7684\u5f62\u5f0f\u8209\u8fa6\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u3001\u6700\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002 \u4e9e\u76db\u91ab\u85e5\u5165\u90782026ASCO\u5e74\u6703\u7684\u6458\u8981\u6838\u5fc3\u4fe1\u606f\u5982\u4e0b\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544aOlverembatinib (HQP1351) combined with blinatumomab in patients with lymphoid blast phase chronic myeloid leukemia (CML-LBP) or Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML-LBP\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027B\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ BCP-ALL\uff09\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a6513\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:51 - 2:57\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002  \u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002  \u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002  Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP-CML\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u6458\u8981\u7de8\u865f\uff1a6510\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002  \u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002  \u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002  Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 8:00 - 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002  \u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002  \u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002  \u58c1\u5831\u5c55\u793aUpdated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c\u6458\u8981\u7de8\u865f\uff1a11539\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8089\u7624\uff08Sarcoma\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a   \u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002  \u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002  \u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002  A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684POLARIS-2\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS6608\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a   POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002  A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): GLORA trial in progress\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684GLORA\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS7101\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMatthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u6838\u5fc3\u8981\u9ede\uff1a   GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002  \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 \u500b\u570b\u5bb6 126 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\u672c\u5c46ASCO\u5e74\u6703\u5c07\u65bc5\u670829\u65e5\u81f36\u67082\u65e5\uff08\u7f8e\u570b\u7576\u5730\u6642\u9593\uff09\u5728\u829d\u52a0\u54e5McCormick\u6703\u8b70\u4e2d\u5fc3\u4ee5\u7dda\u4e0a\u7dda\u4e0b\u7d50\u5408\u7684\u5f62\u5f0f\u8209\u8fa6\u3002\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u3001\u6700\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002 \u4e9e\u76db\u91ab\u85e5\u5165\u90782026ASCO\u5e74\u6703\u7684\u6458\u8981\u6838\u5fc3\u4fe1\u606f\u5982\u4e0b\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544aOlverembatinib (HQP1351) combined with blinatumomab in patients with lymphoid blast phase chronic myeloid leukemia (CML-LBP) or Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ BCP-ALL)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u806f\u5408\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u6cbb\u7642\u6dcb\u7cfb\u6025\u8b8a\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML-LBP\uff09\u6216\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027B\u7d30\u80de\u524d\u9ad4\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ BCP-ALL\uff09\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a6513\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:51\u201313:57\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:51 - 2:57\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684Ib\u671f\u7814\u7a76\u63a2\u7d22\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u8c9d\u6797\u59a5\u6b50\u55ae\u6297\u806f\u5408\u65b9\u6848\u5728\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09Ph+ BCP-ALL\u6216CML-LBP\u60a3\u8005\u4e2d\u7684\u61c9\u7528\u3002 \u5165\u7d44\u6642\u5b58\u5728\u967d\u6027\u53ef\u6e2c\u91cf\u7684\u6b98\u7559\u75be\u75c5\uff08MRD\uff09\u4e14\u975e\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u76845\u4f8b\u60a3\u8005\u7d44\u4e2d\uff0c4\u4f8b\u9054\u5230CR\uff0c2\u4f8b\u5be6\u73feMRD\u8f49\u9670\uff0c\u6574\u9ad4\u5b89\u5168\u6027\u53ef\u63a7\u3002 \u9019\u9805\u7814\u7a76\u9996\u6b21\u5728\u570b\u969b\u60a3\u8005\u7fa4\u9ad4\u4e2d\u9a57\u8b49\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u514d\u75ab\u7642\u6cd5\u5728CML-LBP\u8207R\/R Ph+ BCP- ALL\u4e2d\u7684\u53ef\u884c\u6027\u3002 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic-phase chronic myeloid leukemia (CP-CML)\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u4e8c\u7dda\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CP-CML\uff09\u60a3\u8005\u7684\u6700\u65b0\u7642\u6548\u548c\u5b89\u5168\u6027\u6578\u64da\u6458\u8981\u7de8\u865f\uff1a6510\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 13:21\u201313:27\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670831\u65e5 \u51cc\u66682:21 \u2013 2:27\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u9ece\u7def\u660e\u6559\u6388\uff0c\u83ef\u4e2d\u79d1\u6280\u5927\u5b78\u540c\u6fdf\u91ab\u5b78\u9662\u9644\u5c6c\u5354\u548c\u91ab\u9662\u8840\u6db2\u79d1\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u662f\u4e00\u9805\u5728\u4e2d\u570b\u958b\u5c55\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u4f5c\u70ba\u4e8c\u7dda\u6cbb\u7642\u65b9\u6848\u7684\u6709\u6548\u6027\u8207\u5b89\u5168\u6027\u3002 \u572842\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7b2c24\u5468\u671f\u6642\uff0c\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\u7387\u905491.3%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u905460.9%\u3002\u572832\u4f8b\u4e00\u7dda\u4f7f\u7528\u4e8c\u4ee3TKI\u5931\u6557\u7684\u60a3\u8005\u4e2d\uff0c\u4ecd\u670981.3%\u7372\u5f97\u4e86CCyR\uff0c50%\u9054\u5230MMR\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002 \u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u7ddaTKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u4e14\u7121T315I\u7a81\u8b8a\u7684CP-CML\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e26\u5e36\u4f86\u8f03\u9ad8\u7684MMR\u548cCCyR\u7387\u3002 Alrizomadlin (APG-115) alone or in combination with Lisaftoclax (APG-2575) for the treatment of pediatric patients with relapsed\/metastatic rhabdomyosarcoma (RMS) or other soft-tissue sarcomas (STSs)Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u5fa9\u767c\/\u8f49\u79fb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\uff08RMS\uff09\u6216\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\uff08STSs\uff09\u5152\u7ae5\u60a3\u8005\u6458\u8981\u7de8\u865f\uff1a10012\u5c55\u793a\u5f62\u5f0f\uff1a\u5feb\u901f\u53e3\u982d\u5831\u544a\u5206\u6703\u5834\u6a19\u984c\uff1a\u5152\u7ae5\u816b\u7624II\uff08Pediatric Oncology II\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e745\u670830\u65e5 8:00 - 8:06\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e745\u670830\u65e5 21:00\u201321:06\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5f35\u7ffc\u9ddf\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5152\u7ae5\u816b\u7624\u79d1\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u662f\u4e00\u9805\u570b\u5167\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30\u4e86Alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408\u5229\u6c99\u6258\u514b\u62c9\uff0c\u7528\u65bc\u7d93\u591a\u7dda\u91cd\u5ea6\u6cbb\u7642\u7684\u5fa9\u767c\/\u8f49\u79fb\u6027\u5152\u7ae5\u6a6b\u7d0b\u808c\u8089\u7624\u3001\u5c24\u6587\u8089\u7624\u3001\u795e\u7d93\u6bcd\u7d30\u80de\u7624\u53ca\u5176\u4ed6\u8edf\u7d44\u7e54\u8089\u7624\u7684\u5b89\u5168\u6027\u8207\u521d\u6b65\u7642\u6548\u3002 \u7d50\u679c\u986f\u793a\u55ae\u85e5\u53ca\u806f\u5408\u7d44\u5747\u7121\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u4e0d\u826f\u53cd\u61c9\u4ee5\u80c3\u8178\u9053\u3001\u8840\u6db2\u5b78\u6bd2\u6027\u70ba\u4e3b\uff0c\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u5c11\u898b\uff0c\u7121\u6cbb\u7642\u76f8\u95dc\u6b7b\u4ea1\u53ca\u505c\u85e5\u3002\u7642\u6548\u65b9\u9762\uff0c\u55ae\u85e5\u7d44 1 \u4f8b\u96e3\u6cbb\u6027\u6a6b\u7d0b\u808c\u8089\u7624\u9054CR\uff1b\u806f\u5408\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u9054 30%\u3001\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u9054 80%\u3002 \u8a72\u65b9\u6848\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5728\u5152\u7ae5\u76f8\u95dc\u5be6\u9ad4\u7624\u4e2d\u521d\u6b65\u5c55\u73fe\u6297\u816b\u7624\u6d3b\u6027\uff0c\u503c\u5f97\u9032\u4e00\u6b65\u7814\u7a76\u3002 \u58c1\u5831\u5c55\u793aUpdated clinical and translational results of olverembatinib (HQP1351) in patients with succinate dehydrogenase (SDH)-deficient tumors\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\u7f3a\u9677\u578b\uff08SDH-\uff09\u816b\u7624\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u548c\u8f49\u5316\u7814\u7a76\u7d50\u679c\u6458\u8981\u7de8\u865f\uff1a11539\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8089\u7624\uff08Sarcoma\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 13:30\u201316:30\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67082\u65e5 \u51cc\u66682:30\u20135:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u90b1\u6d77\u6ce2\u6559\u6388\uff0c\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u83ef\u5357\u816b\u7624\u5b78\u570b\u5bb6\u91cd\u9ede\u5be6\u9a57\u5ba4\uff0c\u816b\u7624\u91ab\u5b78\u5354\u540c\u5275\u65b0\u4e2d\u5fc3\u6838\u5fc3\u8981\u9ede\uff1a \u9019\u662f\u4e00\u9805\u5728SDH\u7f3a\u9677\u578b\u816b\u7624\u4e2d\u7684\u7814\u7a76\uff0c\u8a55\u4f30\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u5728SDH\u7f3a\u9677\u578bGIST\u548c\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002 \u572826\u4f8bSDH\u7f3a\u9677\u578bGIST\u60a3\u8005\u4e2d\uff0c6\u4f8b\uff0823.1%\uff09\u60a3\u8005\u7684\u6700\u4f73\u7642\u6548\u70baPR\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9577\u905425.7\u500b\u6708\uff1b\u57286\u4f8bSDH\u7f3a\u9677\u578b\u526f\u795e\u7d93\u7bc0\u7624\u60a3\u8005\u4e2d\uff0c4\u4f8b\u60a3\u8005\u89c0\u5bdf\u5230\u6700\u4f73\u7642\u6548\uff0cSD\u6301\u7e8c\u22654\u500b\u5468\u671f\uff08CBR\uff0c66.7%\uff09\uff0c\u4e2d\u4f4dPFS\u70ba8.25\u500b\u6708\u3002 \u8a72\u7814\u7a76\u9996\u6b21\u95e1\u660e\u4e86\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904ep38-CD36\u901a\u8def\u6291\u5236\u8102\u80aa\u9178\u4fc3\u9032\u7684\u816b\u7624\u7d30\u80de\u9077\u79fb\u7684\u65b0\u6a5f\u5236\uff0c\u70baSDH\u7f3a\u9677\u578b\u816b\u7624\u7684\u6cbb\u7642\u63d0\u4f9b\u4e86\u5168\u65b0\u601d\u8def\u3002 A phase 3 study of olverembatinib (HQP1351) in patients with chronic-phase chronic myeloid leukemia: POLARIS-2 trial in progress\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u6cbb\u7642\u6162\u6027\u671f\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u60a3\u8005\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684POLARIS-2\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS6608\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u767d\u8840\u75c5\u3001\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\u53ca\u540c\u7a2e\u7570\u9ad4\u79fb\u690d\uff08Hematologic Malignancies\u2014Leukemia, Myelodysplastic Syndromes, and Allotransplant\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aElias Jabbour, MD\uff0c\u7f8e\u570b\u5fb7\u514b\u85a9\u65af\u5927\u5b78MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u767d\u8840\u75c5\u79d1\u6838\u5fc3\u8981\u9ede\uff1a POLARIS-2\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002 \u8a72\u7814\u7a76\u5305\u542b\u5169\u500b\u7368\u7acb\u968a\u5217\u3002Part A\u5c07\u81f3\u5c11\u63a5\u53d7\u904e\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u671fCML\u60a3\u8005\u63092:1\u96a8\u6a5f\u5206\u914d\u81f3\u5967\u96f7\u5df4\u66ff\u5c3c\u7d44\u6216\u535a\u8212\u66ff\u5c3c\u7d44\uff1bPart B\u70ba\u55ae\u81c2\u7814\u7a76\uff0c\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u651c\u5e36T315I\u7a81\u8b8a\u7684\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u4e3b\u8981\u7d42\u9ede\u5747\u70ba24\u5468\u7684\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\u7387\u3002 A global multicenter, open-label, randomized, phase 3 registrational study of lisaftoclax (APG-2575) in previously treated chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL): GLORA trial in progress\u5229\u6c99\u6258\u514b\u62c9\uff08APG-2575\uff09\u6cbb\u7642\u65e2\u5f80\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u96a8\u6a5f\u3001III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff1a\u6b63\u5728\u9032\u884c\u4e2d\u7684GLORA\u8a66\u9a57\u6458\u8981\u7de8\u865f\uff1aTPS7101\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u5206\u6703\u5834\u6a19\u984c\uff1a\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u2014\u2014\u6dcb\u5df4\u7624\u548c\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Hematologic Malignancies\u2014Lymphoma and Chronic Lymphocytic Leukemia\uff09\u5831\u544a\u6642\u9593\uff1a2026\u5e746\u67081\u65e5 9:00\u201312:00\uff08\u7f8e\u570b\u4e2d\u90e8\u6642\u9593\uff092026\u5e746\u67081\u65e5 22:00\u2013\u6b21\u65e5\u51cc\u66681:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMatthew Steven Davids, MD\uff0c\u7f8e\u570b\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\u6838\u5fc3\u8981\u9ede\uff1a GLORA\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c3d\u7684III\u671f\u8a3b\u518a\u7814\u7a76\u3002 \u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u7d93\u226512 \u500b\u6708 BTK \u6291\u5236\u5291\u55ae\u85e5\u6cbb\u7642\u5f8c\u672a\u9054\u5b8c\u5168\u7de9\u89e3\u4e14\u7121\u75be\u75c5\u9032\u5c55\u7684CLL\/SLL\u60a3\u8005\uff0c\u5728\u63a5\u53d7\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408BTK\u6291\u5236\u5291\u6cbb\u7642\u5f8c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u7814\u7a76\u8a08\u5283\u7d0d\u5165\u7d04 440 \u4f8b\u60a3\u8005\uff0c\u5728 18 \u500b\u570b\u5bb6 126 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ALL\uff09\u60a3\u8005POLARIS-1\u7814\u7a76\uff1b\u7372\u7f8e\u570bFDA\u548c\u6b50\u6d32EMA\u8a31\u53ef\u7684\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u7d93\u6cbbCML-CP\u6210\u5e74\u60a3\u8005\u7684POLARIS-2\u7814\u7a76\uff1b\u8a55\u4f30\u8010\u7acb\u514b\u00ae\u6cbb\u7642SDH-\u7f3a\u9677\u578bGIST\u60a3\u8005\u7684POLARIS-3\u7814\u7a76\u3002 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