{"id":437793,"date":"2026-05-22T08:00:00","date_gmt":"2026-05-22T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=437793"},"modified":"2026-05-22T08:00:00","modified_gmt":"2026-05-22T00:00:00","slug":"2026-asco-%e7%a7%91%e5%80%ab%e5%8d%9a%e6%b3%b02%e9%a0%85-%e8%a8%bb%e5%86%8a%e7%a0%94%e7%a9%b6%e5%85%a5%e9%81%b82026-asco%e9%9d%9e%e5%b0%8f%e7%b4%b0%e8%83%9e%e8%82%ba%e7%99%8c%e5%8f%a3%e9%a0%ad","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=437793","title":{"rendered":"2026 ASCO | \u79d1\u502b\u535a\u6cf02\u9805 \u8a3b\u518a\u7814\u7a76\u5165\u90782026 ASCO\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u53e3\u982d\u5831\u544a\u5c08\u5834"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae<\/sup>)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(K\u85e5)\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642PD-L1\u967d\u6027\u665a\u671fNSCLC\uff1a\u96a8\u6a5f\u3001\u5c0d\u7167III\u671f\u8a3b\u518a\u7814\u7a76(OptiTROP-Lung05) (\u6458\u8981\u7de8\u865f#8506)<\/li>\n
  • \u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031\uff0c\u5be7\u6cf0\u840a\u00ae<\/sup>[1]<\/sup>)\u6cbb\u7642RET\u878d\u5408\u967d\u6027NSCLC\u95dc\u9375\u8a3b\u518a\u7814\u7a76 (\u6458\u8981\u7de8\u865f#8505)<\/li>\n<\/ul>\n

    \u6210\u90fd<\/span>2026\u5e745\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u5c07\u65bc\u7576\u5730\u6642\u95935\u670829\u65e5\u81f36\u67082\u65e5\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u884c\u3002\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(“\u79d1\u502b\u535a\u6cf0”\u6216”\u516c\u53f8”\uff0c6990.HK) \u9776\u5411\u4eba\u6ecb\u990a\u7d30\u80de\u8868\u9762\u6297\u539f2 (TROP2)\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269(ADC)\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae<\/sup>)\u3001\u65b0\u4e00\u4ee3\u9078\u64c7\u6027\u8f49\u67d3\u904e\u7a0b\u4e2d\u91cd\u6392(RET)\u6291\u5236\u5291\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031\uff0c\u5be7\u6cf0\u840a\u00ae<\/sup>)\u5169\u9805\u8a3b\u518a\u7814\u7a76\u5165\u9078\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u53e3\u982d\u5831\u544a\u5c08\u5834<\/b>\uff0c\u76f8\u95dc\u7814\u7a76\u6458\u8981\u5168\u6587\u5df2\u65bc\u7576\u5730\u6642\u95932026\u5e745\u670821\u65e5\u767c\u4f48\u5728ASCO\u5b98\u65b9\u7db2\u7ad9[2]<\/sup>\u3002\u6838\u5fc3\u5167\u5bb9\u6982\u8ff0\u5982\u4e0b\uff1a<\/p>\n

    \n<\/p><\/div>\n

    \u7814\u7a76<\/u><\/b>1<\/u><\/b><\/p>\n

    \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297<\/b>(<\/b>sac-TMT<\/b>)<\/b>\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642<\/b>PD-L1<\/b>\u967d\u6027\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c<\/b>(<\/b>NSCLC<\/b>)<\/b>\uff1a\u96a8\u6a5f\u3001\u5c0d\u7167\u2162\u671f\u7814\u7a76<\/b>(<\/b>OptiTROP-Lung05<\/b>) <\/b><\/p>\n

    \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e515:12-15:24 (\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)<\/p>\n

    \u7814\u7a76\u5171\u7d0d\u5165413\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u7cfb\u7d71\u6cbb\u7642\u7684\u7121\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4(EGFR)\/\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u7a81\u8b8a\u4e14\u7a0b\u5f0f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41 (PD-L1)\u8868\u9054\u967d\u6027(\u5b9a\u7fa9\u70ba\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%)\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u8986\u84cb\u9c57\u72c0\u548c\u975e\u9c57\u72c0\u7d44\u7e54\u5b78\u985e\u578b\uff0c\u63091:1\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) (4 mg\/kg\uff0cQ2W)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(400 mg\uff0cQ6W)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5(400 mg, Q6W)\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7d93\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u4f30(BICR) \u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\uff0c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u70ba\u7e3d\u751f\u5b58\u671f(OS)\u3002\u622a\u81f32025\u5e749\u670829\u65e5\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba10.5\u500b\u6708\u3002<\/p>\n

    \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a<\/p>\n

      \n
    • PFS<\/b>\u986f\u8457\u6539\u5584<\/b>\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u986f\u8457\u5ef6\u9577PFS\uff0c\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(\u98a8\u96aa\u6bd4(HR)=0.35\uff1b95%\u7f6e\u4fe1\u5340\u9593(CI)\uff1a0.26-0.47\uff1bp<0.0001)\u3002<\/li>\n
    • \u7de9\u89e3\u7387\u660e\u986f\u63d0\u9ad8<\/b>\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u70ba70.2%\uff0c\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u70ba42.0%\u3002<\/li>\n
    • OS<\/b>\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2<\/b> (HR=0.55\uff1b95% CI\uff1a0.36-0.85)\u3002<\/li>\n
    • \u9810\u8a2d\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4<\/b>\uff1a\u5728PD-L1 TPS 1-49%\u53caTPS\u226550%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.19-0.41)\u548c0.47 (95% CI: 0.29-0.77)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0c PFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002<\/li>\n<\/ul>\n

      \u5b89\u5168\u6027\u65b9\u9762\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u5206\u5225\u70ba55.3%\u548c31.4%\u3002\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u5206\u5225\u70ba3.8%\u548c5.3%\uff1b\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u4e2d\u56e0\u4e0d\u826f\u4e8b\u4ef6\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u70ba4.9%\u3002<\/p>\n

      OptiTROP-Lung05<\/b>\u662f\u9996\u500b\u5728<\/b>PD-L1<\/b>\u967d\u6027\u665a\u671f<\/b>NSCLC<\/b>\u4e00\u7dda\u6cbb\u7642\u4e2d\uff0c\u8b49\u660e<\/b>ADC<\/b>\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u6539\u5584<\/b>PFS<\/b>\u7684<\/b>III<\/b>\u671f\u81e8\u5e8a\u7814\u7a76<\/b>\uff0c\u540c\u6642<\/b>OS<\/b>\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2<\/b>\u3002\u57fa\u65bc\u6b64\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e00\u806f\u5408\u7642\u6cd5\u7684\u88dc\u5145\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(sNDA)\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u548c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5f0f\u3002<\/p>\n

      \u7814\u7a76<\/u><\/b>2<\/u><\/b><\/p>\n

      \u65b0\u4e00\u4ee3\u9078\u64c7\u6027<\/b>RET<\/b>\u6291\u5236\u5291<\/b>(SRI)<\/b>\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c<\/b>(A400\/EP0031)<\/b>\u7528\u65bc\u6cbb\u7642\u665a\u671f<\/b>RET<\/b>\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c<\/b>(NSCLC)<\/b>\u60a3\u8005\u7684\u95dc\u9375<\/b>II<\/b>\u671f\u7814\u7a76\u7684\u7642\u6548\u8207\u5b89\u5168\u6027<\/b><\/p>\n

      \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e514:36-14:48 (\u6458\u8981\u7de8\u865f#8505\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de)<\/p>\n

      \u622a\u81f32025\u5e7410\u670829\u65e5\uff0c\u7814\u7a76\u5171\u7d0d\u516571\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u542b\u9251\u5316\u7642\u53ca\u514d\u75ab\u6cbb\u7642\u7684\u60a3\u8005(\u7d93\u6cbb\u60a3\u8005)\u53ca92\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u60a3\u8005(\u521d\u6cbb\u60a3\u8005)\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba22.6\u500b\u6708\u548c20.7\u500b\u6708\u3002<\/p>\n

      \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a<\/p>\n

        \n
      • \u7d93\u7368\u7acb\u5be9\u67e5\u59d4\u54e1\u6703(IRC)\u78ba\u8a8d\u7684ORR\u5728\u7d93\u6cbb\u60a3\u8005\u4e2d\u70ba87.1%(95% CI: 77.0-93.9)\uff0c\u5728\u521d\u6cbb\u60a3\u8005\u4e2d\u70ba81.3%(95% CI: 71.8-88.7)\uff1b<\/li>\n
      • \u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u8005\u7684mPFS\u5206\u5225\u70ba27.5\u500b\u6708(\u672a\u6210\u719f)\u548cNR\uff0c24\u500b\u6708PFS\u7387\u5206\u5225\u70ba52.1%\u548c59.9%\uff1b<\/li>\n
      • mOS\u5747\u672a\u9054\u5230\uff0c\u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u800524\u500b\u6708OS\u7387\u5206\u5225\u70ba65.7%\u53ca74.1%\u3002<\/li>\n
      • \u5728\u57fa\u7dda\u5b58\u5728\u8166\u8f49\u79fb\u7684\u60a3\u8005\u4e2d(\u7d93\u6cbb\u7d4423\u4f8b\uff0c\u521d\u6cbb\u7d4416\u4f8b)\uff0cORR\u5206\u5225\u70ba82.6%\u548c75.0%\uff0c\u4e14\u5169\u500b\u4f47\u5217\u4e2d\u5747\u67096\u4f8b\u60a3\u8005\u7372\u5f97\u9871\u5167\u5b8c\u5168\u7de9\u89e3\u3002<\/li>\n<\/ul>\n

        \u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u767c\u751f\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u3002\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(TRAEs)\u767c\u751f\u7387\u70ba40.5%\uff0c\u50c51.2%\u7684\u60a3\u8005(2\u4f8b)\u56e0TRAEs\u6c38\u4e45\u505c\u85e5\uff0c\u672a\u767c\u751f\u81f4\u547d\u6027TRAEs\u3002<\/p>\n

        \u57fa\u65bc\u6b64\u9805\u7814\u7a76\u7d50\u679c\uff0c\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(NDA)\u5df2\u7372NMPA\u53d7\u7406\u3002<\/p>\n

        \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297<\/u><\/b>(sac-TMT)(<\/u><\/b>\u4f73\u6cf0\u840a<\/u><\/b>\u00ae<\/sup><\/u>)<\/u><\/b><\/p>\n

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        \u95dc\u65bc\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c<\/u><\/b>(A400\/EP0031)(<\/u><\/b>\u5be7\u6cf0\u840a<\/u><\/b>\u00ae<\/sup><\/u><\/b> )<\/u><\/b><\/p>\n

        \u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u662f\u4e00\u6b3e\u65b0\u578b\u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291\uff0c\u958b\u767c\u7528\u65bc\u6cbb\u7642NSCLC\u3001\u7532\u72c0\u817a\u9ad3\u6a23\u7624(MTC)\u4ee5\u53ca\u5176\u4ed6RET\u8b8a\u7570\u7684\u5be6\u9ad4\u7624\u3002\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u7684NDA\u5df2\u7372NMPA\u53d7\u7406\u3002\u516c\u53f8\u4ea6\u5728\u4e2d\u570b\u9032\u884c\u4e00\u9805\u5176\u7528\u65bc\u6cbb\u7642RET+\u5be6\u9ad4\u7624\u7684Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

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        \u95dc\u65bc\u79d1\u502b\u535a\u6cf0<\/u><\/b><\/p>\n

        \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31”\u79d1\u502b\u535a\u6cf0”\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee8\u500b\u9069\u61c9\u75c7\u5df2\u7372\u6279\u4e0a\u5e02\uff0c1\u500b\u5c08\u6848\u8655\u65bcNDA\u968e\u6bb5\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM<\/sup>\uff0c\u5df2\u67092\u500bADC\u9805\u76ee5\u500b\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002<\/p>\n

        \n\n\n\n\n\n
        \n

        [1]<\/sup> \u5546\u54c1\u540d\u5f85NMPA\u6279\u51c6<\/span><\/p>\n<\/td>\n<\/tr>\n

        \n

        [2]<\/sup>\u00a0\u00a0 https:\/\/meetings.asco.org\/meetings\/2026-asco-annual-meeting\/335\/program-guide\/scheduled-sessions<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n

        \n

        [3]<\/sup> \u53ef\u745e\u9054\u00ae<\/sup>(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC(\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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\u5546\u54c1\u540d\u5f85NMPA\u6279\u51c6 \u00a0\u00a0 https:\/\/meetings.asco.org\/meetings\/2026-asco-annual-meeting\/335\/program-guide\/scheduled-sessions \u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC(\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=437793\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2026 ASCO | \u79d1\u502b\u535a\u6cf02\u9805 \u8a3b\u518a\u7814\u7a76\u5165\u90782026 ASCO\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u53e3\u982d\u5831\u544a\u5c08\u5834 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(K\u85e5)\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642PD-L1\u967d\u6027\u665a\u671fNSCLC\uff1a\u96a8\u6a5f\u3001\u5c0d\u7167III\u671f\u8a3b\u518a\u7814\u7a76(OptiTROP-Lung05) (\u6458\u8981\u7de8\u865f#8506) \u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031\uff0c\u5be7\u6cf0\u840a\u00ae)\u6cbb\u7642RET\u878d\u5408\u967d\u6027NSCLC\u95dc\u9375\u8a3b\u518a\u7814\u7a76 (\u6458\u8981\u7de8\u865f#8505) \u6210\u90fd2026\u5e745\u670822\u65e5 \/\u7f8e\u901a\u793e\/ -- 2026\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703(ASCO)\u5e74\u6703\u5c07\u65bc\u7576\u5730\u6642\u95935\u670829\u65e5\u81f36\u67082\u65e5\u5728\u7f8e\u570b\u829d\u52a0\u54e5\u8209\u884c\u3002\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8("\u79d1\u502b\u535a\u6cf0"\u6216"\u516c\u53f8"\uff0c6990.HK) \u9776\u5411\u4eba\u6ecb\u990a\u7d30\u80de\u8868\u9762\u6297\u539f2 (TROP2)\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269(ADC)\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae)\u3001\u65b0\u4e00\u4ee3\u9078\u64c7\u6027\u8f49\u67d3\u904e\u7a0b\u4e2d\u91cd\u6392(RET)\u6291\u5236\u5291\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031\uff0c\u5be7\u6cf0\u840a\u00ae)\u5169\u9805\u8a3b\u518a\u7814\u7a76\u5165\u9078\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u53e3\u982d\u5831\u544a\u5c08\u5834\uff0c\u76f8\u95dc\u7814\u7a76\u6458\u8981\u5168\u6587\u5df2\u65bc\u7576\u5730\u6642\u95932026\u5e745\u670821\u65e5\u767c\u4f48\u5728ASCO\u5b98\u65b9\u7db2\u7ad9\u3002\u6838\u5fc3\u5167\u5bb9\u6982\u8ff0\u5982\u4e0b\uff1a \u7814\u7a761 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642PD-L1\u967d\u6027\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\uff1a\u96a8\u6a5f\u3001\u5c0d\u7167\u2162\u671f\u7814\u7a76(OptiTROP-Lung05) \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e515:12-15:24 (\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de) \u7814\u7a76\u5171\u7d0d\u5165413\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u7cfb\u7d71\u6cbb\u7642\u7684\u7121\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4(EGFR)\/\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u7a81\u8b8a\u4e14\u7a0b\u5f0f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41 (PD-L1)\u8868\u9054\u967d\u6027(\u5b9a\u7fa9\u70ba\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%)\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u8986\u84cb\u9c57\u72c0\u548c\u975e\u9c57\u72c0\u7d44\u7e54\u5b78\u985e\u578b\uff0c\u63091:1\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) (4 mg\/kg\uff0cQ2W)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(400 mg\uff0cQ6W)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5(400 mg, Q6W)\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7d93\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u4f30(BICR) \u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\uff0c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u70ba\u7e3d\u751f\u5b58\u671f(OS)\u3002\u622a\u81f32025\u5e749\u670829\u65e5\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba10.5\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a PFS\u986f\u8457\u6539\u5584\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u986f\u8457\u5ef6\u9577PFS\uff0c\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(\u98a8\u96aa\u6bd4(HR)=0.35\uff1b95%\u7f6e\u4fe1\u5340\u9593(CI)\uff1a0.26-0.47\uff1bp<0.0001)\u3002 \u7de9\u89e3\u7387\u660e\u986f\u63d0\u9ad8\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u70ba70.2%\uff0c\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u70ba42.0%\u3002 OS\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2 (HR=0.55\uff1b95% CI\uff1a0.36-0.85)\u3002 \u9810\u8a2d\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS 1-49%\u53caTPS\u226550%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.19-0.41)\u548c0.47 (95% CI: 0.29-0.77)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0c PFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u5206\u5225\u70ba55.3%\u548c31.4%\u3002\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u5206\u5225\u70ba3.8%\u548c5.3%\uff1b\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u4e2d\u56e0\u4e0d\u826f\u4e8b\u4ef6\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u70ba4.9%\u3002 OptiTROP-Lung05\u662f\u9996\u500b\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\uff0c\u8b49\u660eADC\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u6539\u5584PFS\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u540c\u6642OS\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\u3002\u57fa\u65bc\u6b64\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e00\u806f\u5408\u7642\u6cd5\u7684\u88dc\u5145\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(sNDA)\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u548c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5f0f\u3002 \u7814\u7a762 \u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291(SRI)\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031)\u7528\u65bc\u6cbb\u7642\u665a\u671fRET\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u7684\u95dc\u9375II\u671f\u7814\u7a76\u7684\u7642\u6548\u8207\u5b89\u5168\u6027 \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e514:36-14:48 (\u6458\u8981\u7de8\u865f#8505\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de) \u622a\u81f32025\u5e7410\u670829\u65e5\uff0c\u7814\u7a76\u5171\u7d0d\u516571\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u542b\u9251\u5316\u7642\u53ca\u514d\u75ab\u6cbb\u7642\u7684\u60a3\u8005(\u7d93\u6cbb\u60a3\u8005)\u53ca92\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u60a3\u8005(\u521d\u6cbb\u60a3\u8005)\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba22.6\u500b\u6708\u548c20.7\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a 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0.19-0.41)\u548c0.47 (95% CI: 0.29-0.77)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0c PFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u5206\u5225\u70ba55.3%\u548c31.4%\u3002\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u5206\u5225\u70ba3.8%\u548c5.3%\uff1b\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u4e2d\u56e0\u4e0d\u826f\u4e8b\u4ef6\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u70ba4.9%\u3002 OptiTROP-Lung05\u662f\u9996\u500b\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\uff0c\u8b49\u660eADC\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u6539\u5584PFS\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u540c\u6642OS\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\u3002\u57fa\u65bc\u6b64\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e00\u806f\u5408\u7642\u6cd5\u7684\u88dc\u5145\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(sNDA)\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u548c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5f0f\u3002 \u7814\u7a762 \u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291(SRI)\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031)\u7528\u65bc\u6cbb\u7642\u665a\u671fRET\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u7684\u95dc\u9375II\u671f\u7814\u7a76\u7684\u7642\u6548\u8207\u5b89\u5168\u6027 \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e514:36-14:48 (\u6458\u8981\u7de8\u865f#8505\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de) \u622a\u81f32025\u5e7410\u670829\u65e5\uff0c\u7814\u7a76\u5171\u7d0d\u516571\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u542b\u9251\u5316\u7642\u53ca\u514d\u75ab\u6cbb\u7642\u7684\u60a3\u8005(\u7d93\u6cbb\u60a3\u8005)\u53ca92\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u60a3\u8005(\u521d\u6cbb\u60a3\u8005)\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba22.6\u500b\u6708\u548c20.7\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a \u7d93\u7368\u7acb\u5be9\u67e5\u59d4\u54e1\u6703(IRC)\u78ba\u8a8d\u7684ORR\u5728\u7d93\u6cbb\u60a3\u8005\u4e2d\u70ba87.1%(95% CI: 77.0-93.9)\uff0c\u5728\u521d\u6cbb\u60a3\u8005\u4e2d\u70ba81.3%(95% CI: 71.8-88.7)\uff1b \u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u8005\u7684mPFS\u5206\u5225\u70ba27.5\u500b\u6708(\u672a\u6210\u719f)\u548cNR\uff0c24\u500b\u6708PFS\u7387\u5206\u5225\u70ba52.1%\u548c59.9%\uff1b mOS\u5747\u672a\u9054\u5230\uff0c\u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u800524\u500b\u6708OS\u7387\u5206\u5225\u70ba65.7%\u53ca74.1%\u3002 \u5728\u57fa\u7dda\u5b58\u5728\u8166\u8f49\u79fb\u7684\u60a3\u8005\u4e2d(\u7d93\u6cbb\u7d4423\u4f8b\uff0c\u521d\u6cbb\u7d4416\u4f8b)\uff0cORR\u5206\u5225\u70ba82.6%\u548c75.0%\uff0c\u4e14\u5169\u500b\u4f47\u5217\u4e2d\u5747\u67096\u4f8b\u60a3\u8005\u7372\u5f97\u9871\u5167\u5b8c\u5168\u7de9\u89e3\u3002 \u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u767c\u751f\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u3002\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(TRAEs)\u767c\u751f\u7387\u70ba40.5%\uff0c\u50c51.2%\u7684\u60a3\u8005(2\u4f8b)\u56e0TRAEs\u6c38\u4e45\u505c\u85e5\uff0c\u672a\u767c\u751f\u81f4\u547d\u6027TRAEs\u3002 \u57fa\u65bc\u6b64\u9805\u7814\u7a76\u7d50\u679c\uff0c\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(NDA)\u5df2\u7372NMPA\u53d7\u7406\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 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\u5546\u54c1\u540d\u5f85NMPA\u6279\u51c6 \u00a0\u00a0 https:\/\/meetings.asco.org\/meetings\/2026-asco-annual-meeting\/335\/program-guide\/scheduled-sessions \u53ef\u745e\u9054\u00ae(\u5e15\u535a\u5229\u73e0\u55ae\u6297)\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC(\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=437793","og_locale":"zh_TW","og_type":"article","og_title":"2026 ASCO | \u79d1\u502b\u535a\u6cf02\u9805 \u8a3b\u518a\u7814\u7a76\u5165\u90782026 ASCO\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u53e3\u982d\u5831\u544a\u5c08\u5834 - 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(TROP2)\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269(ADC)\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae)\u3001\u65b0\u4e00\u4ee3\u9078\u64c7\u6027\u8f49\u67d3\u904e\u7a0b\u4e2d\u91cd\u6392(RET)\u6291\u5236\u5291\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031\uff0c\u5be7\u6cf0\u840a\u00ae)\u5169\u9805\u8a3b\u518a\u7814\u7a76\u5165\u9078\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u53e3\u982d\u5831\u544a\u5c08\u5834\uff0c\u76f8\u95dc\u7814\u7a76\u6458\u8981\u5168\u6587\u5df2\u65bc\u7576\u5730\u6642\u95932026\u5e745\u670821\u65e5\u767c\u4f48\u5728ASCO\u5b98\u65b9\u7db2\u7ad9\u3002\u6838\u5fc3\u5167\u5bb9\u6982\u8ff0\u5982\u4e0b\uff1a \u7814\u7a761 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(PD-L1)\u8868\u9054\u967d\u6027(\u5b9a\u7fa9\u70ba\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%)\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u8986\u84cb\u9c57\u72c0\u548c\u975e\u9c57\u72c0\u7d44\u7e54\u5b78\u985e\u578b\uff0c\u63091:1\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) (4 mg\/kg\uff0cQ2W)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(400 mg\uff0cQ6W)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5(400 mg, Q6W)\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7d93\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u4f30(BICR) \u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\uff0c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u70ba\u7e3d\u751f\u5b58\u671f(OS)\u3002\u622a\u81f32025\u5e749\u670829\u65e5\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba10.5\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a PFS\u986f\u8457\u6539\u5584\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u986f\u8457\u5ef6\u9577PFS\uff0c\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(\u98a8\u96aa\u6bd4(HR)=0.35\uff1b95%\u7f6e\u4fe1\u5340\u9593(CI)\uff1a0.26-0.47\uff1bp<0.0001)\u3002 \u7de9\u89e3\u7387\u660e\u986f\u63d0\u9ad8\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u70ba70.2%\uff0c\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u70ba42.0%\u3002 OS\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2 (HR=0.55\uff1b95% CI\uff1a0.36-0.85)\u3002 \u9810\u8a2d\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS 1-49%\u53caTPS\u226550%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.19-0.41)\u548c0.47 (95% CI: 0.29-0.77)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0c PFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u5206\u5225\u70ba55.3%\u548c31.4%\u3002\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u5206\u5225\u70ba3.8%\u548c5.3%\uff1b\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u4e2d\u56e0\u4e0d\u826f\u4e8b\u4ef6\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u70ba4.9%\u3002 OptiTROP-Lung05\u662f\u9996\u500b\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\uff0c\u8b49\u660eADC\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u6539\u5584PFS\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u540c\u6642OS\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\u3002\u57fa\u65bc\u6b64\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e00\u806f\u5408\u7642\u6cd5\u7684\u88dc\u5145\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(sNDA)\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u548c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5f0f\u3002 \u7814\u7a762 \u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291(SRI)\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031)\u7528\u65bc\u6cbb\u7642\u665a\u671fRET\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u7684\u95dc\u9375II\u671f\u7814\u7a76\u7684\u7642\u6548\u8207\u5b89\u5168\u6027 \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e514:36-14:48 (\u6458\u8981\u7de8\u865f#8505\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de) \u622a\u81f32025\u5e7410\u670829\u65e5\uff0c\u7814\u7a76\u5171\u7d0d\u516571\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u542b\u9251\u5316\u7642\u53ca\u514d\u75ab\u6cbb\u7642\u7684\u60a3\u8005(\u7d93\u6cbb\u60a3\u8005)\u53ca92\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u60a3\u8005(\u521d\u6cbb\u60a3\u8005)\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba22.6\u500b\u6708\u548c20.7\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a \u7d93\u7368\u7acb\u5be9\u67e5\u59d4\u54e1\u6703(IRC)\u78ba\u8a8d\u7684ORR\u5728\u7d93\u6cbb\u60a3\u8005\u4e2d\u70ba87.1%(95% CI: 77.0-93.9)\uff0c\u5728\u521d\u6cbb\u60a3\u8005\u4e2d\u70ba81.3%(95% CI: 71.8-88.7)\uff1b \u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u8005\u7684mPFS\u5206\u5225\u70ba27.5\u500b\u6708(\u672a\u6210\u719f)\u548cNR\uff0c24\u500b\u6708PFS\u7387\u5206\u5225\u70ba52.1%\u548c59.9%\uff1b mOS\u5747\u672a\u9054\u5230\uff0c\u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u800524\u500b\u6708OS\u7387\u5206\u5225\u70ba65.7%\u53ca74.1%\u3002 \u5728\u57fa\u7dda\u5b58\u5728\u8166\u8f49\u79fb\u7684\u60a3\u8005\u4e2d(\u7d93\u6cbb\u7d4423\u4f8b\uff0c\u521d\u6cbb\u7d4416\u4f8b)\uff0cORR\u5206\u5225\u70ba82.6%\u548c75.0%\uff0c\u4e14\u5169\u500b\u4f47\u5217\u4e2d\u5747\u67096\u4f8b\u60a3\u8005\u7372\u5f97\u9871\u5167\u5b8c\u5168\u7de9\u89e3\u3002 \u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u767c\u751f\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u3002\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(TRAEs)\u767c\u751f\u7387\u70ba40.5%\uff0c\u50c51.2%\u7684\u60a3\u8005(2\u4f8b)\u56e0TRAEs\u6c38\u4e45\u505c\u85e5\uff0c\u672a\u767c\u751f\u81f4\u547d\u6027TRAEs\u3002 \u57fa\u65bc\u6b64\u9805\u7814\u7a76\u7d50\u679c\uff0c\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(NDA)\u5df2\u7372NMPA\u53d7\u7406\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 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\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u4e00\u7dda\u6cbb\u7642PD-L1\u967d\u6027\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\uff1a\u96a8\u6a5f\u3001\u5c0d\u7167\u2162\u671f\u7814\u7a76(OptiTROP-Lung05) \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e515:12-15:24 (\u6458\u8981\u7de8\u865f#8506\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de) \u7814\u7a76\u5171\u7d0d\u5165413\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u7cfb\u7d71\u6cbb\u7642\u7684\u7121\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad4(EGFR)\/\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u7a81\u8b8a\u4e14\u7a0b\u5f0f\u6027\u7d30\u80de\u6b7b\u4ea1\u914d\u9ad41 (PD-L1)\u8868\u9054\u967d\u6027(\u5b9a\u7fa9\u70ba\u816b\u7624\u7d30\u80de\u967d\u6027\u6bd4\u4f8b\u5206\u6578(TPS)\u22651%)\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u60a3\u8005\uff0c\u8986\u84cb\u9c57\u72c0\u548c\u975e\u9c57\u72c0\u7d44\u7e54\u5b78\u985e\u578b\uff0c\u63091:1\u96a8\u6a5f\u5206\u914d\u63a5\u53d7\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT) (4 mg\/kg\uff0cQ2W)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(400 mg\uff0cQ6W)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u55ae\u85e5(400 mg, Q6W)\u6cbb\u7642\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7d93\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u8a55\u4f30(BICR) \u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\uff0c\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u70ba\u7e3d\u751f\u5b58\u671f(OS)\u3002\u622a\u81f32025\u5e749\u670829\u65e5\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba10.5\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a PFS\u986f\u8457\u6539\u5584\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8f03\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u986f\u8457\u5ef6\u9577PFS\uff0c\u4e2d\u4f4dPFS\u70ba\u5c1a\u672a\u9054\u5230(NR) vs 5.7\u500b\u6708(\u98a8\u96aa\u6bd4(HR)=0.35\uff1b95%\u7f6e\u4fe1\u5340\u9593(CI)\uff1a0.26-0.47\uff1bp<0.0001)\u3002 \u7de9\u89e3\u7387\u660e\u986f\u63d0\u9ad8\uff1a\u7d93BICR\u8a55\u4f30\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u70ba70.2%\uff0c\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u70ba42.0%\u3002 OS\u5c1a\u672a\u6210\u719f\u4f46\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2 (HR=0.55\uff1b95% CI\uff1a0.36-0.85)\u3002 \u9810\u8a2d\u4e9e\u7d44\u7372\u76ca\u4e00\u81f4\uff1a\u5728PD-L1 TPS 1-49%\u53caTPS\u226550%\u60a3\u8005\u4e2d\uff0cPFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.19-0.41)\u548c0.47 (95% CI: 0.29-0.77)\uff1b\u5728\u975e\u9c57\u72c0\u548c\u9c57\u72c0NSCLC\u60a3\u8005\u4e2d\uff0c PFS HR\u5206\u5225\u70ba0.28 (95% CI: 0.18-0.43)\u548c0.44 (95% CI: 0.29-0.66)\u3002 \u5b89\u5168\u6027\u65b9\u9762\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u22653\u7d1a\u6cbb\u7642\u671f\u9593\u4e0d\u826f\u4e8b\u4ef6(TEAEs)\u767c\u751f\u7387\u5206\u5225\u70ba55.3%\u548c31.4%\u3002\u56e0\u4e0d\u826f\u4e8b\u4ef6\u5c0e\u81f4\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u6216\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u5206\u5225\u70ba3.8%\u548c5.3%\uff1b\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7d44\u4e2d\u56e0\u4e0d\u826f\u4e8b\u4ef6\u6c38\u4e45\u505c\u85e5\u7684\u6bd4\u4f8b\u70ba4.9%\u3002 OptiTROP-Lung05\u662f\u9996\u500b\u5728PD-L1\u967d\u6027\u665a\u671fNSCLC\u4e00\u7dda\u6cbb\u7642\u4e2d\uff0c\u8b49\u660eADC\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u53ef\u986f\u8457\u6539\u5584PFS\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u540c\u6642OS\u986f\u793a\u7a4d\u6975\u7372\u76ca\u8da8\u52e2\u3002\u57fa\u65bc\u6b64\u7814\u7a76\u7d50\u679c\uff0c\u9019\u4e00\u806f\u5408\u7642\u6cd5\u7684\u88dc\u5145\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(sNDA)\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u53d7\u7406\u548c\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u5be9\u6279\u7a0b\u5f0f\u3002 \u7814\u7a762 \u65b0\u4e00\u4ee3\u9078\u64c7\u6027RET\u6291\u5236\u5291(SRI)\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c(A400\/EP0031)\u7528\u65bc\u6cbb\u7642\u665a\u671fRET\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u60a3\u8005\u7684\u95dc\u9375II\u671f\u7814\u7a76\u7684\u7642\u6548\u8207\u5b89\u5168\u6027 \u53e3\u982d\u5831\u544a\uff1a\u7576\u5730\u6642\u95935\u670829\u65e514:36-14:48 (\u6458\u8981\u7de8\u865f#8505\uff0c\u80ba\u764c\u2014\u8f49\u79fb\u6027\u975e\u5c0f\u7d30\u80de) \u622a\u81f32025\u5e7410\u670829\u65e5\uff0c\u7814\u7a76\u5171\u7d0d\u516571\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u542b\u9251\u5316\u7642\u53ca\u514d\u75ab\u6cbb\u7642\u7684\u60a3\u8005(\u7d93\u6cbb\u60a3\u8005)\u53ca92\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u60a3\u8005(\u521d\u6cbb\u60a3\u8005)\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u9593\u70ba22.6\u500b\u6708\u548c20.7\u500b\u6708\u3002 \u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a \u7d93\u7368\u7acb\u5be9\u67e5\u59d4\u54e1\u6703(IRC)\u78ba\u8a8d\u7684ORR\u5728\u7d93\u6cbb\u60a3\u8005\u4e2d\u70ba87.1%(95% CI: 77.0-93.9)\uff0c\u5728\u521d\u6cbb\u60a3\u8005\u4e2d\u70ba81.3%(95% CI: 71.8-88.7)\uff1b \u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u8005\u7684mPFS\u5206\u5225\u70ba27.5\u500b\u6708(\u672a\u6210\u719f)\u548cNR\uff0c24\u500b\u6708PFS\u7387\u5206\u5225\u70ba52.1%\u548c59.9%\uff1b mOS\u5747\u672a\u9054\u5230\uff0c\u7d93\u6cbb\u60a3\u8005\u8207\u521d\u6cbb\u60a3\u800524\u500b\u6708OS\u7387\u5206\u5225\u70ba65.7%\u53ca74.1%\u3002 \u5728\u57fa\u7dda\u5b58\u5728\u8166\u8f49\u79fb\u7684\u60a3\u8005\u4e2d(\u7d93\u6cbb\u7d4423\u4f8b\uff0c\u521d\u6cbb\u7d4416\u4f8b)\uff0cORR\u5206\u5225\u70ba82.6%\u548c75.0%\uff0c\u4e14\u5169\u500b\u4f47\u5217\u4e2d\u5747\u67096\u4f8b\u60a3\u8005\u7372\u5f97\u9871\u5167\u5b8c\u5168\u7de9\u89e3\u3002 \u5b89\u5168\u6027\u53ef\u63a7\uff0c\u4e14\u672a\u767c\u751f\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u3002\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(TRAEs)\u767c\u751f\u7387\u70ba40.5%\uff0c\u50c51.2%\u7684\u60a3\u8005(2\u4f8b)\u56e0TRAEs\u6c38\u4e45\u505c\u85e5\uff0c\u672a\u767c\u751f\u81f4\u547d\u6027TRAEs\u3002 \u57fa\u65bc\u6b64\u9805\u7814\u7a76\u7d50\u679c\uff0c\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u7528\u65bc\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027NSCLC\u6210\u4eba\u60a3\u8005\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb(NDA)\u5df2\u7372NMPA\u53d7\u7406\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 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