{"id":431447,"date":"2026-04-30T11:31:00","date_gmt":"2026-04-30T03:31:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=431447"},"modified":"2026-04-30T11:31:00","modified_gmt":"2026-04-30T03:31:00","slug":"%e5%be%b7%e6%98%87%e6%bf%9f%e9%86%ab%e8%97%a5%e5%9c%a8aacr-2026%e5%a4%a7%e6%9c%83%e5%85%ac%e4%bd%88kras%e7%ae%a1%e7%b7%9a%e6%9c%80%e6%96%b0%e9%80%b2%e5%b1%95%ef%bc%9b%e6%96%b0%e4%b8%80%e4%bb%a3kras-g1","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=431447","title":{"rendered":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>\u5728\u63a8\u85a6<\/b><b>II<\/b><b>\u671f\u5291\u91cf\uff08<\/b><b>RP2D<\/b><b>\uff0c<\/b><b>600 mg<\/b><b>\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0c<\/b><b>elisrasib<\/b><b>\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002<\/b><\/p>\n<ul type=\"disc\">\n<li><b><i>\u4e8c\u7dda\u53ca\u4ee5\u4e0a<\/i><\/b><b><i>KRAS G12C<\/i><\/b><b><i>\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08<\/i><\/b><b><i>NSCLC<\/i><\/b><b><i>\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08<\/i><\/b><b><i>ORR<\/i><\/b><b><i>\uff09<\/i><\/b><b><i>58.8%<\/i><\/b><b><i>\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08<\/i><\/b><b><i>mPFS<\/i><\/b><b><i>\uff09<\/i><\/b><b><i>12.2<\/i><\/b><b><i>\u500b\u6708<\/i><\/b><\/li>\n<li><b><i>\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08<\/i><\/b><b><i>CRC<\/i><\/b><b><i>\uff09\uff1a<\/i><\/b><b><i>ORR 46.9%<\/i><\/b><b><i>\uff0c<\/i><\/b><b><i>mPFS 9.5<\/i><\/b><b><i>\u500b\u6708<\/i><\/b><\/li>\n<li><b><i>\u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08<\/i><\/b><b><i>PDAC<\/i><\/b><b><i>\uff09\uff1a<\/i><\/b><b><i>ORR 65.0%<\/i><\/b><b><i>\uff0c<\/i><\/b><b><i>mPFS 13.5<\/i><\/b><b><i>\u500b\u6708<\/i><\/b><\/li>\n<\/ul>\n<p><b>\u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904e<\/b><b>KRAS G12C<\/b><b>\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684<\/b><b>NSCLC<\/b><b>\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08<\/b><b>ORR 32.3%<\/b><b>\uff0c<\/b><b>mPFS 8.1<\/b><b>\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002<\/b><\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2026\u5e744\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002<\/p>\n<p><b>\u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027<\/b><\/p>\n<p><span id=\"spanHghltcdf9\">\u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002<\/span><\/p>\n<p>\u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08<span id=\"spanHghltea4c\">n=31<\/span>\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002<\/p>\n<p><span id=\"spanHghlt4ac5\">\u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002<\/span><\/p>\n<p><b>\u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5<\/b><\/p>\n<p>elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002<\/p>\n<p>\u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002<\/p>\n<p><b>\u5c08\u5bb6\u89c0\u9ede<\/b><\/p>\n<p>\u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d<\/p>\n<p>\u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d<\/p>\n<p><b>AACR 2026<\/b><b>\u5927\u6703\u5176\u4ed6\u5c55\u793a<\/b><\/p>\n<p>\u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>First in human phase 1 study of D3S-002, a purposely designed ERK1\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09<\/li>\n<li>First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09<\/li>\n<li>D3S-003: an allele-specific KRAS G12D (OFF\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09<\/li>\n<\/ul>\n<p>\u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d<\/p>\n<p><b>\u95dc\u65bc<\/b><b>Elisrasib<\/b><b>\uff08<\/b><b>D3S-001<\/b><b>\uff09<br \/><\/b>Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002<\/p>\n<p>\u4ee3\u8868\u6027\u8ad6\u6587\uff1a<br \/>\u2022 Cancer Discovery (2024) 14(9):1675\u20131698<br \/>\u2022 Nature Medicine (2025) 31(8):2768\u20132777<\/p>\n<p><b>\u95dc\u65bc<\/b><b>D3S-002<\/b><br \/>D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002<\/p>\n<p>\u4ee3\u8868\u6027\u8ad6\u6587\uff1a<br \/>\u2022 Cancer Research, 2023<\/p>\n<p><b>\u95dc\u65bc<\/b><b>D3S-003<\/b><br \/>D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>D3 Bio<\/b><br \/>D3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002<\/p>\n<p>\u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1a<a href=\"http:\/\/www.d3bio.com\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.d3bio.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c6&#8230;<\/p>\n","protected":false},"author":16,"featured_media":431448,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-431447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0celisrasib\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002   \u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff0958.8%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff0912.2\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1aORR 46.9%\uff0cmPFS 9.5\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\uff1aORR 65.0%\uff0cmPFS 13.5\u500b\u6708  \u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904eKRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684NSCLC\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08ORR 32.3%\uff0cmPFS 8.1\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002 \u4e0a\u6d772026\u5e744\u670830\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002     \u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002 \u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027 \u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002 \u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08n=31\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002 \u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002 \u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5 elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002 \u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002 \u5c08\u5bb6\u89c0\u9ede \u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d \u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d AACR 2026\u5927\u6703\u5176\u4ed6\u5c55\u793a \u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a   First in human phase 1 study of D3S-002, a purposely designed ERK1\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09  First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09  D3S-003: an allele-specific KRAS G12D (OFF\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09  \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Discovery (2024) 14(9):1675\u20131698\u2022 Nature Medicine (2025) 31(8):2768\u20132777 \u95dc\u65bcD3S-002D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Research, 2023 \u95dc\u65bcD3S-003D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcD3 BioD3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1awww.d3bio.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=431447\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0celisrasib\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002   \u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff0958.8%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff0912.2\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1aORR 46.9%\uff0cmPFS 9.5\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\uff1aORR 65.0%\uff0cmPFS 13.5\u500b\u6708  \u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904eKRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684NSCLC\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08ORR 32.3%\uff0cmPFS 8.1\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002 \u4e0a\u6d772026\u5e744\u670830\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002     \u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002 \u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027 \u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002 \u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08n=31\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002 \u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002 \u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5 elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002 \u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002 \u5c08\u5bb6\u89c0\u9ede \u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d \u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d AACR 2026\u5927\u6703\u5176\u4ed6\u5c55\u793a \u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a   First in human phase 1 study of D3S-002, a purposely designed ERK1\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09  First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09  D3S-003: an allele-specific KRAS G12D (OFF\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09  \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Discovery (2024) 14(9):1675\u20131698\u2022 Nature Medicine (2025) 31(8):2768\u20132777 \u95dc\u65bcD3S-002D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Research, 2023 \u95dc\u65bcD3S-003D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcD3 BioD3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1awww.d3bio.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=431447\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-30T03:31:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n\t<meta property=\"og:image:width\" content=\"3000\" \/>\n\t<meta property=\"og:image:height\" content=\"1990\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548\",\"datePublished\":\"2026-04-30T03:31:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447\"},\"wordCount\":233,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/D3_BIO_DeShengJi_Logo.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447\",\"name\":\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/D3_BIO_DeShengJi_Logo.jpg\",\"datePublished\":\"2026-04-30T03:31:00+00:00\",\"description\":\"\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0celisrasib\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002 \u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff0958.8%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff0912.2\u500b\u6708 \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1aORR 46.9%\uff0cmPFS 9.5\u500b\u6708 \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\uff1aORR 65.0%\uff0cmPFS 13.5\u500b\u6708 \u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904eKRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684NSCLC\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08ORR 32.3%\uff0cmPFS 8.1\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002 \u4e0a\u6d772026\u5e744\u670830\u65e5 \\\/\u7f8e\u901a\u793e\\\/ --\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002 \u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002 \u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027 \u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002 \u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08n=31\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002 \u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002 \u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5 elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002 \u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002 \u5c08\u5bb6\u89c0\u9ede \u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d \u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d AACR 2026\u5927\u6703\u5176\u4ed6\u5c55\u793a \u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a First in human phase 1 study of D3S-002, a purposely designed ERK1\\\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09 First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09 D3S-003: an allele-specific KRAS G12D (OFF\\\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09 \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Discovery (2024) 14(9):1675\u20131698\u2022 Nature Medicine (2025) 31(8):2768\u20132777 \u95dc\u65bcD3S-002D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\\\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Research, 2023 \u95dc\u65bcD3S-003D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcD3 BioD3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1awww.d3bio.com\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/D3_BIO_DeShengJi_Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/04\\\/D3_BIO_DeShengJi_Logo.jpg\",\"width\":400,\"height\":225},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=431447#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0celisrasib\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002   \u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff0958.8%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff0912.2\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1aORR 46.9%\uff0cmPFS 9.5\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\uff1aORR 65.0%\uff0cmPFS 13.5\u500b\u6708  \u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904eKRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684NSCLC\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08ORR 32.3%\uff0cmPFS 8.1\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002 \u4e0a\u6d772026\u5e744\u670830\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002     \u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002 \u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027 \u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002 \u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08n=31\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002 \u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002 \u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5 elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002 \u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002 \u5c08\u5bb6\u89c0\u9ede \u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d \u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d AACR 2026\u5927\u6703\u5176\u4ed6\u5c55\u793a \u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a   First in human phase 1 study of D3S-002, a purposely designed ERK1\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09  First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09  D3S-003: an allele-specific KRAS G12D (OFF\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09  \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Discovery (2024) 14(9):1675\u20131698\u2022 Nature Medicine (2025) 31(8):2768\u20132777 \u95dc\u65bcD3S-002D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Research, 2023 \u95dc\u65bcD3S-003D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcD3 BioD3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1awww.d3bio.com","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=431447","og_locale":"zh_TW","og_type":"article","og_title":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0celisrasib\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002   \u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff0958.8%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff0912.2\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1aORR 46.9%\uff0cmPFS 9.5\u500b\u6708  \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\uff1aORR 65.0%\uff0cmPFS 13.5\u500b\u6708  \u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904eKRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684NSCLC\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08ORR 32.3%\uff0cmPFS 8.1\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002 \u4e0a\u6d772026\u5e744\u670830\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002     \u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002 \u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027 \u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002 \u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08n=31\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002 \u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002 \u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5 elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002 \u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002 \u5c08\u5bb6\u89c0\u9ede \u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d \u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d AACR 2026\u5927\u6703\u5176\u4ed6\u5c55\u793a \u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a   First in human phase 1 study of D3S-002, a purposely designed ERK1\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09  First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09  D3S-003: an allele-specific KRAS G12D (OFF\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09  \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Discovery (2024) 14(9):1675\u20131698\u2022 Nature Medicine (2025) 31(8):2768\u20132777 \u95dc\u65bcD3S-002D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Research, 2023 \u95dc\u65bcD3S-003D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcD3 BioD3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1awww.d3bio.com","og_url":"https:\/\/pingtungtimes.com.tw\/?p=431447","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2026-04-30T03:31:00+00:00","og_image":[{"width":3000,"height":1990,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=431447"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548","datePublished":"2026-04-30T03:31:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=431447"},"wordCount":233,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/04\/D3_BIO_DeShengJi_Logo.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=431447","url":"https:\/\/pingtungtimes.com.tw\/?p=431447","name":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/04\/D3_BIO_DeShengJi_Logo.jpg","datePublished":"2026-04-30T03:31:00+00:00","description":"\u5728\u63a8\u85a6II\u671f\u5291\u91cf\uff08RP2D\uff0c600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\uff0celisrasib\u55ae\u85e5\u5728\u4e09\u5927\u4e3b\u8981\u816b\u7624\u985e\u578b\u4e2d\u5c55\u73fe\u51fa\u986f\u8457\u7642\u6548\u3002 \u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff0958.8%\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff0912.2\u500b\u6708 \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\uff1aORR 46.9%\uff0cmPFS 9.5\u500b\u6708 \u4e8c\u7dda\u53ca\u4ee5\u4e0a\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\uff1aORR 65.0%\uff0cmPFS 13.5\u500b\u6708 \u6b64\u5916\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904eKRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u8010\u85e5\u7684NSCLC\u60a3\u8005\u4e2d\u4ea6\u89c0\u5bdf\u5230\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7642\u6548\uff08ORR 32.3%\uff0cmPFS 8.1\u500b\u6708\uff09\uff0c\u4e26\u5728\u4f34\u6709\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u8f49\u79fb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u986f\u8457\u6297\u816b\u7624\u6d3b\u6027\u3002 \u4e0a\u6d772026\u5e744\u670830\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u5168\u7403\u81e8\u5e8a\u968e\u6bb5\u751f\u7269\u6280\u8853\u516c\u53f8\u5fb7\u6607\u6fdf\u91ab\u85e5\u4eca\u65e5\u5ba3\u4f48\uff0c\u5176\u6838\u5fc3\u5728\u7814\u8cc7\u7522elisrasib\uff08D3S-001\uff09\u7684\u6700\u65b0II\u671f\u81e8\u5e8a\u6578\u64da\uff0c\u4ee5\u53caKRAS\u9776\u5411\u7ba1\u7dda\u7684\u5176\u4ed6\u81e8\u5e8a\u8207\u81e8\u5e8a\u524d\u7814\u7a76\u9032\u5c55\u3002Elisrasib\u4f5c\u70ba\u4e00\u6b3e\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u5be6\u9ad4\u7624\u4e2d\u5c55\u73fe\u51fa\u5ee3\u6cdb\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u548c\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\uff08PDAC\uff09\u3002 \u76f8\u95dcII\u671f\u6578\u64da\u5df2\u57282026\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\uff08AACR\uff09\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u767c\u4f48\uff0c\u5305\u62ec\u81e8\u5e8a\u5168\u9ad4\u5927\u6703\uff08\u6458\u8981\u7de8\u865fCT020\uff09\u4ee5\u53ca\u81e8\u5e8a\u8a66\u9a57\u5c08\u984c\u7814\u8a0e\u6703\uff08\u6458\u8981\u7de8\u865fCT303\uff09\uff0c\u6703\u8b70\u65bc\u7f8e\u570b\u52a0\u5229\u798f\u5c3c\u4e9e\u5dde\u8056\u5730\u4e9e\u54e5\u8209\u884c\u3002 \u591a\u9069\u61c9\u75c7\u4e2d\u5c55\u73fe\u5ee3\u6cdb\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u6d3b\u6027 \u5728\u4e8c\u7dda\u53ca\u4ee5\u4e0aKRAS G12C\u6291\u5236\u5291\u672a\u7d93\u6cbb\u7642\u7684NSCLC\u60a3\u8005\uff08n=68\uff09\u4e2d\uff0celisrasib\u5728RP2D\u5291\u91cf\uff08600 mg\u6bcf\u65e5\u4e00\u6b21\uff09\u4e0b\u8868\u73fe\u51fa\u5f37\u52c1\u7642\u6548\uff0cORR\u70ba58.8%\uff0c\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08mDoR\uff09\u70ba16.5\u500b\u6708\uff0cmPFS\u70ba12.2\u500b\u6708\u3002 \u5728\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u4e14\u51fa\u73fe\u8010\u85e5\u7684\u665a\u671fNSCLC\u60a3\u8005\uff08n=31\uff09\u4e2d\uff0cORR\u70ba32.3%\uff0cmDoR\u70ba15.6\u500b\u6708\uff0cmPFS\u70ba8.1\u500b\u6708\u3002\u5728\u65e2\u5f80\u63a5\u53d7\u6cbb\u7642\u7684\u7d50\u76f4\u8178\u764c\u60a3\u8005\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=32\uff09\u53ca\u806f\u5408\u897f\u59a5\u6614\u55ae\u6297\uff08n=29\uff09\u5747\u986f\u793a\u51fa\u986f\u8457\u7642\u6548\uff1a\u55ae\u85e5\u6cbb\u7642ORR\u70ba46.9%\uff0cmDoR\u70ba13.1\u500b\u6708\uff0cmPFS\u70ba9.5\u500b\u6708\uff1b\u806f\u5408\u6cbb\u7642ORR\u70ba62.1%\uff0cmDoR\u70ba7.0\u500b\u6708\uff0cmPFS\u70ba8.2\u500b\u6708\u3002\u516c\u53f8\u8a08\u5283\u9032\u4e00\u6b65\u958b\u5c55\u7814\u7a76\uff0c\u4ee5\u8a55\u4f30\u512a\u5316\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5f9e\u800c\u63d0\u5347\u7d50\u76f4\u8178\u764c\u4e2d\u7684\u7de9\u89e3\u6301\u7e8c\u6027\u3002 \u5728\u665a\u671f\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u4e2d\uff0celisrasib\u55ae\u85e5\uff08n=20\uff09\u6cbb\u7642\u5be6\u73feORR 65.0%\uff0cmDoR 10.8\u500b\u6708\uff0cmPFS 13.5\u500b\u6708\u3002 \u826f\u597d\u7684\u5b89\u5168\u6027\u7279\u5fb5 elisrasib\u5728NSCLC\u3001CRC\u53caPDAC\u60a3\u8005\u4e2d\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u30023\u7d1a\u53ca\u4ee5\u4e0a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u767c\u751f\u7387\u5728\u5404\u7624\u7a2e\u4e2d\u70ba8.7%\u81f315.6%\u3002 \u8207\u897f\u59a5\u6614\u55ae\u6297\u806f\u5408\u6cbb\u7642\u6642\uff0c3\u7d1aTRAE\u767c\u751f\u7387\u6709\u6240\u589e\u52a0\uff0c\u4f46\u7e3d\u9ad4\u53ef\u63a7\uff0c\u4e14\u4e3b\u8981\u8207\u897f\u59a5\u6614\u55ae\u6297\u5df2\u77e5\u5b89\u5168\u6027\u7279\u5fb5\u76f8\u95dc\u3002\u50c5\u5831\u544a1\u4f8b\u77ed\u66ab\u4e14\u7121\u75c7\u72c0\u76844\u7d1a\u4f4e\u9240\u8840\u75c7\u4e8b\u4ef6\uff0c\u672a\u89c0\u5bdf\u5230\u5176\u4ed64\u7d1a\u62165\u7d1aTRAE\u3002 \u5c08\u5bb6\u89c0\u9ede \u97d3\u570b\u5ef6\u4e16\u5927\u5b78\u91ab\u5b78\u9662\u5ef6\u4e16\u764c\u75c7\u4e2d\u5fc3\u816b\u7624\u5167\u79d1\u6559\u6388\u3001\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005Byoung Chul Cho\uff08MD,\u00a0 PhD\uff09\u8868\u793a\uff1a\u300c\u5373\u4f7f\u5728\u7b2c\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u7684\u60c5\u6cc1\u4e0b\uff0celisrasib\u4ecd\u80fd\u5920\u5e36\u4f86\u66f4\u6df1\u4e14\u66f4\u6301\u4e45\u7684\u816b\u7624\u7de9\u89e3\u3002\u9019\u4e9b\u7d50\u679c\u8868\u660e\uff0celisrasib\u6709\u671b\u986f\u8457\u6539\u5584KRAS G12C\u7a81\u8b8a\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\u6548\u679c\u3002\u300d \u4ed6\u88dc\u5145\u9053\uff1a\u300c\u5728\u65e2\u5f80\u4e00\u4ee3\u6291\u5236\u5291\u9032\u5c55\u7684\u60a3\u8005\u4e2d\uff0c\u6211\u5011\u767c\u73fe5\u4f8b\u5b58\u5728KRAS\u57fa\u56e0\u64f4\u589e\uff0c\u9019\u662fKRAS G12C\u6291\u5236\u5291\u8010\u85e5\u7684\u91cd\u8981\u6a5f\u5236\u3002\u5728\u90195\u4f8b\u60a3\u8005\u4e2d\uff0c4\u4f8b\u51fa\u73fe\u816b\u7624\u7e2e\u5c0f\uff0c3\u4f8b\u9054\u5230\u5ba2\u89c0\u7de9\u89e3\uff0c\u75be\u75c5\u63a7\u5236\u7387\u70ba100%\uff0c\u9032\u4e00\u6b65\u652f\u6301elisrasib\u5728\u9019\u4e00\u7279\u5b9a\u751f\u7269\u6a19\u8a8c\u7269\u4eba\u7fa4\u4e2d\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u300d AACR 2026\u5927\u6703\u5176\u4ed6\u5c55\u793a \u5fb7\u6607\u6fdf\u91ab\u85e5\u9084\u5c55\u793a\u4e86\u5176KRAS\u7ba1\u7dda\u7684\u5176\u4ed6\u91cd\u8981\u9032\u5c55\uff0c\u5305\u62ec\uff1a First in human phase 1 study of D3S-002, a purposely designed ERK1\/2 inhibitor, in advanced solid tumors with MAPK pathway mutations\u202f\u202f\u2014 \u58c1\u5831\uff08\u6458\u8981CT060\uff09 First-in-human clinical pharmacokinetic prediction of D3S-003, an orally bioavailable dual-state KRAS G12D Inhibitor\u202f\u2014 \u58c1\u5831\uff08\u6458\u89811831\uff09 D3S-003: an allele-specific KRAS G12D (OFF\/ON) orally available inhibitor with best-in-class potential \u2014\u00a0\u58c1\u5831\uff08\u6458\u89814569\uff09 \u5fb7\u6607\u6fdf\u91ab\u85e5\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9673\u4e4b\u9375\u535a\u58eb\u8868\u793a\uff1a\u300celisrasib\u5728\u591a\u7a2eKRAS G12C\u7a81\u8b8a\u816b\u7624\u4e2d\u5c55\u73fe\u51fa\u4e00\u81f4\u4e14\u5f37\u52c1\u7684\u81e8\u5e8a\u6d3b\u6027\uff0c\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u516c\u53f8KRAS\u7ba1\u7dda\u7684\u6574\u9ad4\u5be6\u529b\u8207\u767c\u5c55\u52d5\u80fd\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0celisrasib\u6709\u671b\u6210\u70baKRAS G12C\u7a81\u8b8a\u816b\u7624\u7684\u91cd\u8981\u57fa\u790e\u6cbb\u7642\u65b9\u6848\u3002\u300d \u95dc\u65bcElisrasib\uff08D3S-001\uff09Elisrasib \u662f\u4e00\u6b3e\u65b0\u4e00\u4ee3 KRAS G12C \u6291\u5236\u5291\uff0c\u65e8\u5728\u5be6\u73fe\u5feb\u901f\u3001\u5145\u5206\u4e14\u9078\u64c7\u6027\u7684\u9776\u9ede\u7d50\u5408\u3002\u8a72\u85e5\u7269\u53ef\u8207 KRAS G12C \u7684 GDP \u7d50\u5408\uff08OFF\uff09\u69cb\u8c61\u767c\u751f\u5171\u50f9\u7d50\u5408\uff0c\u5f9e\u800c\u6709\u6548\u963b\u65b7\u6838\u7518\u9178\u5faa\u74b0\u4e26\u6291\u5236\u81f4\u764c\u4fe1\u865f\u901a\u8def\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u986f\u793a\u5176\u5177\u6709\u5f37\u6548\u6d3b\u6027\uff0c\u5728\u81e8\u5e8a\u76f8\u95dc\u66b4\u9732\u6c34\u5e73\u4e0b\u53ef\u5be6\u73fe\u5b8c\u5168\u7684 KRAS G12C \u9776\u9ede\u4f54\u9818\uff0c\u4e26\u5177\u5099\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff09\u6ef2\u900f\u80fd\u529b\u3002Elisrasib \u76ee\u524d\u6b63\u5728\u5168\u7403\u7bc4\u570d\u5167\u958b\u5c55 II \u671f\u55ae\u85e5\u53ca\u806f\u5408\u6cbb\u7642\u7814\u7a76\uff0c\u8986\u84cb KRAS G12C \u7a81\u8b8a\u5be6\u9ad4\u7624\uff08\u5305\u62ec NSCLC\u3001\u7d50\u76f4\u8178\u764c\uff08CRC) \u3001\u80f0\u817a\u764c\uff08PDAC) \u7b49\uff09\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Discovery (2024) 14(9):1675\u20131698\u2022 Nature Medicine (2025) 31(8):2768\u20132777 \u95dc\u65bcD3S-002D3S-002\u662f\u4e00\u7a2e\u9078\u64c7\u6027ERK1\/2\u6291\u5236\u5291\uff0c\u5c08\u70ba\u806f\u5408\u6cbb\u7642\u7b56\u7565\u8a2d\u8a08\uff0c\u901a\u904e\u5c0dMAPK\u901a\u8def\u9032\u884c\u7e31\u5411\u6291\u5236\u4ee5\u589e\u5f37\u7642\u6548\u4e26\u514b\u670d\u7372\u5f97\u6027\u8010\u85e5\uff0c\u5c24\u5176\u9069\u7528\u65bc\u65e2\u5f80\u63a5\u53d7KRAS G12C\u6291\u5236\u5291\u6cbb\u7642\u7684\u816b\u7624\u60a3\u8005\u3002 \u4ee3\u8868\u6027\u8ad6\u6587\uff1a\u2022 Cancer Research, 2023 \u95dc\u65bcD3S-003D3S-003\u662f\u4e00\u7a2e\u5177\u6709\u5dee\u7570\u5316\u512a\u52e2\u7684KRAS G12D\u6291\u5236\u5291\uff0c\u53ef\u540c\u6642\u9776\u5411\u6d3b\u6027\uff08ON\uff09\u548c\u975e\u6d3b\u6027\uff08OFF\uff09\u69cb\u8c61\uff0c\u91dd\u5c0d\u6700\u5e38\u898b\u7684KRAS\u7a81\u8b8a\u4e4b\u4e00\u3002\u8a72\u9805\u76ee\u65e8\u5728\u62d3\u5c55\u516c\u53f8\u591a\u7b49\u4f4d\u57fa\u56e0KRAS\u7522\u54c1\u7ba1\u7dda\uff0c\u70ba\u8907\u96dc\u4e14\u4e0d\u65b7\u6f14\u8b8a\u7684KRAS\u9a45\u52d5\u816b\u7624\u63d0\u4f9b\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002 \u95dc\u65bcD3 BioD3 Bio\u662f\u4e00\u5bb6\u5168\u7403\u6027\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u5177\u6709\u300c\u540c\u985e\u9996\u5275\u300d\u6216\u300c\u540c\u985e\u6700\u4f73\u300d\u6f5b\u529b\u7684\u816b\u7624\u53ca\u514d\u75ab\u75be\u75c5\u5275\u65b0\u7642\u6cd5\u7684\u767c\u73fe\u3001\u958b\u767c\u53ca\u8a3b\u518a\u3002\u516c\u53f8\u4f9d\u6258\u6df1\u539a\u7684\u81e8\u5e8a\u6d1e\u5bdf\u8207\u751f\u7269\u6a19\u8a8c\u7269\u9a45\u52d5\u7b56\u7565\uff0c\u6301\u7e8c\u63a8\u9032\u91dd\u5c0d\u95dc\u9375\u81f4\u764c\u9a45\u52d5\u56e0\u5b50\u53ca\u514d\u75ab\u901a\u8def\u7684\u7522\u54c1\u7ba1\u7dda\u4f48\u5c40\uff0c\u4e26\u64c1\u6709\u6240\u6709\u5728\u7814\u9805\u76ee\u7684\u5168\u7403\u6b0a\u76ca\u3002 \u66f4\u591a\u4fe1\u606f\u8acb\u8a2a\u554f\uff1awww.d3bio.com","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=431447"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/04\/D3_BIO_DeShengJi_Logo.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/04\/D3_BIO_DeShengJi_Logo.jpg","width":400,"height":225},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=431447#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u5fb7\u6607\u6fdf\u91ab\u85e5\u5728AACR 2026\u5927\u6703\u516c\u4f48KRAS\u7ba1\u7dda\u6700\u65b0\u9032\u5c55\uff1b\u65b0\u4e00\u4ee3KRAS G12C\u6291\u5236\u5291Elisrasib\uff08D3S-001\uff09\u5728\u591a\u7624\u7a2e\u4e2d\u5c55\u73fe\u51fa\u5f37\u52c1II\u671f\u7642\u6548"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/431447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=431447"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/431447\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/431448"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=431447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=431447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=431447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}