{"id":430310,"date":"2026-04-27T09:50:00","date_gmt":"2026-04-27T01:50:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=430310"},"modified":"2026-04-27T09:50:00","modified_gmt":"2026-04-27T01:50:00","slug":"%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91%e5%88%a9%e7%94%9f%e5%a6%a5%e7%8d%b2-2026-%e7%89%88-csco%e7%b3%bb%e5%88%97%e6%8c%87%e5%8d%97%e5%a4%9a%e9%a0%85%e9%87%8d","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=430310","title":{"rendered":"\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291\u5229\u751f\u59a5\u00ae\u7372 2026 \u7248 CSCO\u7cfb\u5217\u6307\u5357\u591a\u9805\u91cd\u78c5\u63a8\u85a6"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2026\u5e744\u670827\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u76841\u985e\u65b0\u85e5\u3001\u4e2d\u570b\u9996\u500b\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\u5229\u751f\u59a5<sup>\u00ae<\/sup>\uff08\u5229\u6c99\u6258\u514b\u62c9\uff09\uff0c\u7372\u7d0d\u5165\u6700\u65b0\u767c\u4f48\u76842026\u5e74\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u7cfb\u5217\u6307\u5357\u3002\u57282026 \u7248\u300aCSCO \u6dcb\u5df4\u7624\u8a3a\u7642\u6307\u5357\u300b\u8207\u300aCSCO \u60e1\u6027\u8840\u6db2\u75c5\u8a3a\u7642\u6307\u5357\u300b\u4e2d\uff0c\u5229\u6c99\u6258\u514b\u62c9\u6191\u501f\u5728\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5353\u8d8a\u8868\u73fe\uff0c\u6b63\u5f0f\u78ba\u7acb\u4e86\u5728\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u764c\uff08CLL\/SLL\uff09\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u548c\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u9818\u57df\u7684\u6b0a\u5a01\u63a8\u85a6\u5730\u4f4d \u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>\u4e00\u3001 <b>CLL\/SLL <\/b><b>\u9818\u57df\uff1a\u5be6\u73fe\u5f9e\u55ae\u85e5\u5230\u806f\u5408\u7684\u5168\u8986\u84cb<\/b><\/p>\n<p>\u57282026\u7248\u300aCSCO \u6dcb\u5df4\u7624\u8a3a\u7642\u6307\u5357\u300b\u4e2d\uff0c\u5229\u6c99\u6258\u514b\u62c9\u5f62\u6210\u4e86\u968e\u68af\u5f0f\u7684\u7cbe\u6e96\u5316\u4f48\u5c40\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>I <\/b><b>\u7d1a\u63a8\u85a6\uff08\u55ae\u85e5<\/b><b>\/<\/b><b>\u5fa9\u767c\u96e3\u6cbb\uff09\uff1a<\/b>\u57fa\u65bcAPG2575CC201\u7814\u7a76\u5728\u9ad8\u5371\u3001BTKi\u7d93\u6cbb\u4eba\u7fa4\u4e2d\u7684\u986f\u8457\u7372\u76ca\uff08ORR\u905462.5%\uff09\uff0c\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u7372<b>I<\/b><b>\u7d1a\u63a8\u85a6<\/b>\uff08\u9ad8\u8b49\u64da\u7d1a\u5225\uff09\uff0c\u6210\u70ba\u5fa9\u767c\u96e3\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7684\u6a19\u6e96\u6cbb\u7642\u65b9\u6848 \u3002<\/li>\n<li><b>II <\/b><b>\u7d1a\u63a8\u85a6\uff08\u806f\u5408\u65b9\u6848<\/b><b>\/<\/b><b>\u5fa9\u767c\u96e3\u6cbb\uff09\uff1a<\/b>\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u5229\u59a5\u6614\u55ae\u6297\u5728\u5fa9\u767c\/\u96e3\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7372 <b>II <\/b><b>\u7d1a\u63a8\u85a6<\/b> \u3002<\/li>\n<li><b>III <\/b><b>\u7d1a\u63a8\u85a6\uff08\u524d\u6cbf\u63a2\u7d22\uff09\uff1a<\/b>\u91dd\u5c0dBTK\u6291\u5236\u5291\u548c\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u5f8c\u5fa9\u767c\/\u96e3\u6cbbCLL\/SLL \u60a3\u8005\uff0c\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u53ef\u66ff\u5c3c\u5c55\u73fe\u51fa\u5de8\u5927\u6cbb\u7642\u6f5b\u529b\uff0cORR\u905496.9%\uff0c<b>\u7372<\/b><b>III<\/b><b>\u7d1a\u63a8\u85a6\uff0c\u662f\u6b64\u985e\u63a8\u85a6\u4e2d\u552f\u4e00\u5217\u5165\u7684<\/b><b>Bcl-2<\/b><b>\u6291\u5236\u5291\u6cbb\u7642\u65b9\u6848<\/b>\u3002<\/li>\n<\/ul>\n<p><b>\u4e8c\u3001 <\/b><b>AML <\/b><b>\u9818\u57df\uff1a\u7cbe\u6e96\u5206\u5c64\u4e0b\u7684\u6838\u5fc3\u4e00\u7dda\u8207\u8010\u85e5\u66ff\u4ee3\u65b9\u6848<\/b><\/p>\n<p>\u57282026\u7248\u300aCSCO \u60e1\u6027\u8840\u6db2\u75c5\u8a3a\u7642\u6307\u5357\u300b\u4e2d\uff0c\u5229\u6c99\u6258\u514b\u62c9\u901a\u904e\u6a5f\u5236\u985e\u5225\u7684\u66f4\u65b0\uff0c\u9032\u4e00\u6b65\u978f\u56fa\u4e86\u5176\u5728\u9ad3\u7cfb\u816b\u7624\u4e2d\u7684\u57fa\u77f3\u5730\u4f4d\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>\u4e00\u7dda\u6838\u5fc3\u63a8\u85a6\uff1a<\/b> \u91dd\u5c0d\u8001\u5e74\/\u4e0d\u9069\u5408\u5f37\u5316\u5316\u7642\uff08Older\/Unfit\uff09\u60a3\u8005\uff0c\u6307\u5357\u5c07\u300cBCL-2 \u6291\u5236\u5291\uff08\u5305\u542b\u5229\u6c99\u6258\u514b\u62c9\uff09\u300d\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\uff08AZA\/DAC\uff09\u6216\u4f4e\u5291\u91cf\u963f\u7cd6\u80de\u7518\uff08LDAC\uff09\u5217\u70ba\u4e00\u7dda\u65b9\u6848\u7684\u6838\u5fc3\u63a8\u85a6 \u3002<\/li>\n<li><b>\u8010\u85e5\u60a3\u8005\u7a81\u7834\uff1a<\/b> \u7279\u5225\u662f\u91dd\u5c0d\u65e2\u5f80\u6709 HMA \u66b4\u9732\u7684 Unfit \u60a3\u8005\uff0c\u6307\u5357\u65b0\u589e\u4e86\u300cLDAC+ Bcl-2\u6291\u5236\u5291\u300d\u65b9\u6848\u3002\u5229\u6c99\u6258\u514b\u62c9\u6191\u501f\u5176\u7368\u7279\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u512a\u52e2\uff0c\u6210\u70ba\u6b64\u985e\u7d93\u6cbb\/\u8010\u85e5\u60a3\u8005\u7684\u91cd\u8981\u66ff\u4ee3\u9078\u64c7 \u3002<\/li>\n<li><b>\u96e3\u6cbb<\/b><b>\/<\/b><b>\u5fa9\u767c\u633d\u6551<\/b>\uff1a\u5c0d\u65e9\u671f\u5fa9\u767c\u60a3\u8005\u9776\u5411\u6cbb\u7642\u6216\u9776\u5411\u806f\u5408\u5316\u7642\u6642\uff0c\u6307\u5357\u65b0\u589e\u4e86\u5229\u6c99\u6258\u514b\u62c9\u540c\u6a23\u53ef\u4f5c\u70baBcl-2\u6291\u5236\u5291\u7684\u53ef\u9078\u85e5\u7269\u3002<\/li>\n<\/ul>\n<p>\u4e09\u3001 MDS \u9818\u57df\uff1a\u5ef6\u7e8c\u4e86 Bcl-2\u6291\u5236\u5291 \u806f\u5408 HMA \u5728\u8f03\u9ad8\u5371MDS\u4e2d\u7684\u6cbb\u7642\u50f9\u503c<\/p>\n<p>\u57282026\u7248\u300aCSCO \u60e1\u6027\u8840\u6db2\u75c5\u8a3a\u7642\u6307\u5357\u300b\u4e2d\uff0c\u5c0d\u65bc\u521d\u6cbb\u8f03\u9ad8\u5371MDS\u53ca\u5fa9\u767c\u3001\u9032\u5c55\u6216\u7121\u53cd\u61c9\u8005\u63a8\u85a6\u4e86\u53bb\u7532\u57fa\u5316\u85e5\u7269HMA\u806f\u5408Bcl-2\u6291\u5236\u5291\u7684\u6cbb\u7642\u65b9\u6848\u3002\u6307\u5357\u4e2d\u4e5f\u63d0\u5230\u65b0\u578bBcl-2\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408AZA\u7528\u65bc\u65b0\u8a3a\u65b7HR-MDS\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u8a66\u9a57\uff08GLORA-4\uff09\u5df2\u7372\u6279\u958b\u5c55\uff0c\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\u3002\u5229\u6c99\u6258\u514b\u62c9\u4f5c\u70ba\u6211\u570b\u9996\u500b\u539f\u5275\u5168\u65b0\u4e00\u4ee3 Bcl-2 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