{"id":430159,"date":"2026-04-26T19:00:00","date_gmt":"2026-04-26T11:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=430159"},"modified":"2026-04-26T19:00:00","modified_gmt":"2026-04-26T11:00:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a8apasl-2026%e7%99%bc%e8%a1%a8%e6%b2%bb%e7%99%82%e7%b5%90%e6%9d%9f%e5%be%8chbsag%e5%8f%8d%e5%bd%88%e7%9a%84%e8%b7%a8%e7%a0%94%e7%a9%b6%e5%88%86%e6%9e%90","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=430159","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c"},"content":{"rendered":"<div>\n<p><i>&#8211; \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG<\/i><i>\u2011<\/i><i>IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII<\/i><i>\u2011<\/i><i>179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG<\/i><i>\u2011<\/i><i>IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002<\/i><\/p>\n<p><i>&#8211; \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e02<\/span><span class=\"legendSpanClass\">2026\u5e744\u670826\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">\u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002<\/p>\n<p>\u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002<\/p>\n<p>\u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002<\/p>\n<p>\u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d<\/p>\n<p>\u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a<\/p>\n<p><b>\u6a19\u984c:<\/b>\u00a0Elebsiran\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790<\/p>\n<p><b>\u6703\u8b70\/\u5831\u544a\u5f62\u5f0f\uff1a<\/b>\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09<\/p>\n<p><b>\u65e5\u671f\u6642\u9593\uff1a<\/b>2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3)<\/p>\n<p><b>\u6f14\u8b1b\u4eba\uff1a<\/b>\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3<\/p>\n<ul type=\"disc\">\n<li>\u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002<\/li>\n<li>\u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002<\/li>\n<li>HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d75.0%\uff0818\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<p><b>\u95dc\u65bc\u4e59\u578b\u809d\u708e<\/b><\/p>\n<p>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002<sup><span id=\"spanHghlta5dd\">[1]<\/span><\/sup>\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002<sup><span id=\"spanHghltf459\">[1]<\/span><\/sup>\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002<sup><span id=\"spanHghlt50d9\">[2]<\/span><\/sup><\/p>\n<p><b>\u95dc\u65bcBRII-179<\/b><\/p>\n<p>BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bcElebsiran<\/b><\/p>\n<p>Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bc\u9a30\u76db\u535a\u85e5<\/b><\/p>\n<p>\u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.briibio.com<\/a>\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[1]<\/sup>\u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0<a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789240091672\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow\" style=\"color: #0000FF\">https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[2]<\/sup>\u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0<a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow\" style=\"color: #0000FF\">https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a><a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow\" style=\"color: #0000FF\">.<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-430159","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"- \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG\u2011IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG\u2011IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002 - \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002 \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022026\u5e744\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002 \u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002 \u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002 \u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d \u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c:\u00a0Elebsiran\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790 \u6703\u8b70\/\u5831\u544a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09 \u65e5\u671f\u6642\u9593\uff1a2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3) \u6f14\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3   \u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002  \u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002  HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d75.0%\uff0818\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002  \u95dc\u65bc\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002 \u95dc\u65bcBRII-179 BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002          \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672        \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.        \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=430159\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"- \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG\u2011IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG\u2011IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002 - \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002 \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022026\u5e744\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002 \u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002 \u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002 \u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d \u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c:\u00a0Elebsiran\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790 \u6703\u8b70\/\u5831\u544a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09 \u65e5\u671f\u6642\u9593\uff1a2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3) \u6f14\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3   \u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002  \u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002  HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d75.0%\uff0818\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002  \u95dc\u65bc\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002 \u95dc\u65bcBRII-179 BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002          \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672        \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.        \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=430159\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-26T11:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c\",\"datePublished\":\"2026-04-26T11:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159\"},\"wordCount\":189,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159\",\"name\":\"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"datePublished\":\"2026-04-26T11:00:00+00:00\",\"description\":\"- \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG\u2011IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\\\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG\u2011IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002 - \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002 \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022026\u5e744\u670826\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002 \u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002 \u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\\\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\\\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002 \u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d \u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c:\u00a0Elebsiran\\\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790 \u6703\u8b70\\\/\u5831\u544a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09 \u65e5\u671f\u6642\u9593\uff1a2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3) \u6f14\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3 \u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\\\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\\\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002 \u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\\\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\\\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002 HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\\\/mL\uff0c\u5176\u4e2d75.0%\uff0818\\\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\\\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\\\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002 \u95dc\u65bc\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002 \u95dc\u65bcBRII-179 BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002 \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\\\/\\\/www.who.int\\\/publications\\\/i\\\/item\\\/9789240091672 \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\\\/\\\/www.who.int\\\/china\\\/health-topics\\\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C. \u00a0\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":\"3000\",\"height\":\"1990\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=430159#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"- \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG\u2011IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG\u2011IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002 - \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002 \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022026\u5e744\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002 \u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002 \u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002 \u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d \u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c:\u00a0Elebsiran\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790 \u6703\u8b70\/\u5831\u544a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09 \u65e5\u671f\u6642\u9593\uff1a2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3) \u6f14\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3   \u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002  \u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002  HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d75.0%\uff0818\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002  \u95dc\u65bc\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002 \u95dc\u65bcBRII-179 BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002          \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672        \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.        \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=430159","og_locale":"zh_TW","og_type":"article","og_title":"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"- \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG\u2011IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG\u2011IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002 - \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002 \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022026\u5e744\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002 \u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002 \u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002 \u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d \u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c:\u00a0Elebsiran\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790 \u6703\u8b70\/\u5831\u544a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09 \u65e5\u671f\u6642\u9593\uff1a2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3) \u6f14\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3   \u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002  \u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002  HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d75.0%\uff0818\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002  \u95dc\u65bc\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002 \u95dc\u65bcBRII-179 BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002          \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672        \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.        \u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=430159","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2026-04-26T11:00:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"","width":"","height":""}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_image":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=430159"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c","datePublished":"2026-04-26T11:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=430159"},"wordCount":189,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=430159","url":"https:\/\/pingtungtimes.com.tw\/?p=430159","name":"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","datePublished":"2026-04-26T11:00:00+00:00","description":"- \u63a5\u53d7\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG\u2011IFN\u03b1\uff09\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u4e26\u5be6\u73fe\u4e86\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u6e05\u9664\u7684\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u6c34\u5e73\u5927\u591a\u4f4e\u65bc10 IU\/mL\uff0cHBV DNA\u53cd\u5f48\u8f03\u70ba\u7f55\u898b\uff0c\u4e14\u672a\u51fa\u73fe\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0c\u63d0\u793a\u6cbb\u7642\u5f8c\u53ef\u7372\u5f97\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u70ba\u5728\u806f\u5408PEG\u2011IFN\u03b1\u8207\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\u5b89\u5168\u505c\u7528\u6838\u7518\uff08\u9178\uff09\u985e\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NRTI\uff09\u63d0\u4f9b\u4e86\u652f\u6301\u3002 - \u7e2e\u77edNRTI\u978f\u56fa\u6cbb\u7642\u671f\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u8aaa\u660e\u5728\u6b64\u985e\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u5177\u6709\u53ef\u884c\u6027\u3002 \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022026\u5e744\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u91ab\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u57282026\u5e744\u670822\u81f325\u65e5\u65bc\u571f\u8033\u5176\u4f0a\u65af\u5766\u5e03\u723e\u8209\u884c\u7684\u7b2c35\u5c46\u4e9e\u592a\u809d\u75c5\u5b78\u6703\u5e74\u6703\uff08APASL\uff09\u4e0a\uff0c\u767c\u8868\u4e86\u4e00\u9805\u95dc\u65bc\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7279\u5fb5\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790\u7d50\u679c\u3002 \u672c\u6b21\u5206\u6790\u8a55\u4f30\u4e86\u5728ENSURE\u548cBRII\u2011179\u2011002\u5169\u9805II\u671f\u7814\u7a76\u4e2d\uff0c\u5be6\u73feHBsAg\u6e05\u9664\u7684NRTI\u7d93\u6cbb\u6162\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u53c3\u8207\u8005\uff0c\u65bc\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u51fa\u73fe\u7684HBsAg\u53cd\u5f48\u60c5\u6cc1\u3002ENSURE\u70ba\u4e00\u9805II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u806f\u5408\u6cbb\u7642\u7b56\u7565\u5728\u6539\u5584\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\u5176\u4e2d\uff0c\u7b2c1\u20133\u968a\u5217\u6bd4\u8f03\u4e86elebsiran\u806f\u5408PEG\u2011IFN\u03b1\u8207PEG\u2011IFN\u03b1\u55ae\u85e5\u6cbb\u7642\u7684\u6cbb\u7642\u6548\u679c\uff1b\u7b2c4\u968a\u5217\u5247\u8a55\u4f30BRII\u2011179\u5728\u7be9\u9078\u514d\u75ab\u5b78\u61c9\u7b54\u512a\u52e2\u4eba\u7fa4\u53ca\u63d0\u5347HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u6f5b\u5728\u4f5c\u7528\u3002BRII\u2011179\u2011002\u70ba\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u7684II\u671f\u6982\u5ff5\u9a57\u8b49\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5728PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u52a0\u7528BRII-179\u7684\u806f\u5408\u65b9\u6848\u3002 \u672c\u6b21\u5206\u6790\u5c0d\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9032\u884c\u4e86\u532f\u7e3d\uff0c\u4ee5\u8a55\u4f30\u63a5\u53d7PEG\u2011IFN\u03b1\u55ae\u85e5\u6216\u806f\u5408elebsiran\u6216BRII\u2011179\u6cbb\u7642\u7684\u53c3\u8207\u8005\u5728EOT\u5f8cHBsAg\u53cd\u5f48\u7684\u767c\u751f\u7387\u3001\u53cd\u5f48\u5e45\u5ea6\u4ee5\u53ca\u5176\u81e8\u5e8a\u76f8\u95dc\u6027\u3002\u7d9c\u5408\u5206\u6790\u986f\u793a\uff0c\u53c3\u8207\u8005\u505c\u85e5\u5f8c\u7e3d\u9ad4\u81e8\u5e8a\u7d50\u5c40\u826f\u597d\uff1aHBsAg\u53cd\u5f48\u8005\u7684\u53cd\u5f48\u6c34\u5e73\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d\u5927\u591a\u6578\u53cd\u5f48\u4f4e\u65bc10 IU\/mL\u3002\u5728\u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u767c\u751f\u7387\u8f03\u4f4e\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u8207\u505c\u7528NRTI\u76f8\u95dc\u7684\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u5347\u9ad8\u3002\u7e3d\u9ad4\u800c\u8a00\uff0c\u9019\u4e9b\u7d50\u679c\u8868\u660e\u53c3\u8207\u8005\u5728\u6cbb\u7642\u7d50\u675f\u5f8c\u7372\u5f97\u4e86\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\uff0c\u9032\u4e00\u6b65\u652f\u6301\u5728\u4ee5 PEG\u2011IFN\u03b1\u70ba\u57fa\u790e\u3001\u806f\u5408\u65b0\u578b\u6cbb\u7642\u624b\u6bb5\u7684\u65b9\u6848\u4e2d\uff0c\u5b89\u5168\u505c\u7528NRTI\u5177\u6709\u53ef\u884c\u6027\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u820724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u671f\u76f8\u6bd4\uff0c\u8f03\u77ed\u7684NRTI\u978f\u56fa\u671f\uff0812\u201320\u5468\uff09\u4e26\u672a\u589e\u52a0HBsAg\u53cd\u5f48\u767c\u751f\u7387\uff0c\u63d0\u793a\u5728\u672a\u4f86\u7684\u6cbb\u7642\u7b56\u7565\u4e2d\uff0c\u7e2e\u77ed\u751a\u81f3\u7701\u7565NRTI\u978f\u56fa\u6cbb\u7642\u671f\u662f\u53ef\u884c\u7684\u3002 \u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u9019\u4e9b\u4e0d\u65b7\u7a4d\u7d2f\u7684\u8b49\u64da\u4f7f\u6211\u5011\u5099\u53d7\u9f13\u821e\uff0c\u8868\u660e\u6211\u5011\u7684\u65b0\u578b\u806f\u5408\u6cbb\u7642\u65b9\u6848\u4e0d\u50c5\u53ef\u4ee5\u5be6\u73fe\u5feb\u901f\u7684HBsAg\u6e05\u9664\uff0c\u9084\u80fd\u5920\u5728\u505c\u85e5\u5f8c\u7dad\u6301\u6301\u4e45\u7684\u514d\u75ab\u5b78\u63a7\u5236\u3002\u9019\u4e9b\u767c\u73fe\u9032\u4e00\u6b65\u589e\u5f37\u4e86\u6211\u5011\u5c0dBRII\u2011179\u548celebsiran\u4f5c\u70ba\u4e0b\u4e00\u4ee3\u4e59\u809d\u6cbb\u7652\u7b56\u7565\u95dc\u9375\u7d44\u6210\u90e8\u5206\u7684\u4fe1\u5fc3\u3002\u6211\u5011\u671f\u5f85\u57282026\u5e74\u6301\u7e8c\u7372\u5f97\u6b63\u5728\u9032\u884c\u7684\u7814\u7a76\u7684\u66f4\u591a\u6578\u64da\u3002\u300d \u53e3\u982d\u5831\u544a\u7684\u5176\u4ed6\u8a73\u7d30\u4fe1\u606f\u5982\u4e0b\uff1a \u6a19\u984c:\u00a0Elebsiran\/BRII\u2011179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u532f\u7e3d\u5206\u6790 \u6703\u8b70\/\u5831\u544a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\uff08\u7b2c58\u5834\uff09 \u65e5\u671f\u6642\u9593\uff1a2026\u5e744\u670825\u65e513:40\u201315:10 (UTC+3) \u6f14\u8b1b\u4eba\uff1a\u8cc8\u7e7c\u6771\u6559\u6388\uff0c\u91ab\u5b78\u535a\u58eb\u3001\u535a\u58eb\u751f\u5c0e\u5e2b\uff0c\u5317\u4eac\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u53cb\u8abc\u91ab\u9662\u809d\u75c5\u7814\u7a76\u4e2d\u5fc3 \u572855\u4f8b\u53c3\u8207\u8005\u4e2d\uff0c\u670924\u4f8b\uff0843.6%\uff09\u89c0\u5bdf\u5230EOT\u5f8cHBsAg\u53cd\u5f48\uff1bNRTI\u978f\u56fa\u6cbb\u7642\u671f\u9593\u53cd\u5f48\u7387\u70ba23.6%\uff0813\/55\uff09\uff0c\u505c\u7528NRTI\u5f8c\u70ba26.8%\uff0811\/41\uff09\uff0c\u5169\u8005\u76f8\u7576\u3002 \u81f3NRTI\u505c\u85e5\u5f8c24\u5468\uff0c\u63a5\u53d712\u201320\u5468\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738715.0%\u30143\/20\u3015\uff09\u8207\u63a5\u53d724\u5468NRTI\u978f\u56fa\u6cbb\u7642\u7684\u53c3\u8207\u8005\uff08\u53cd\u5f48\u738723.8%\u30145\/21\u3015\uff09\u76f8\u6bd4\uff0cHBsAg\u53cd\u5f48\u767c\u751f\u7387\u4e26\u672a\u589e\u52a0\u3002 HBsAg\u53cd\u5f48\u5e45\u5ea6\u7e3d\u9ad4\u6709\u9650\uff0c\u6240\u6709\u53cd\u5f48\u5747\u4f4e\u65bc100 IU\/mL\uff0c\u5176\u4e2d75.0%\uff0818\/24\uff09\u53c3\u8207\u8005\u4ecd\u7dad\u6301\u572810 IU\/mL\u4ee5\u4e0b\u3002 \u505c\u7528NRTI\u5f8c\uff0cHBV DNA\u53cd\u5f48\u7f55\u898b\uff0c\u8d85\u904e90%\uff0838\/41\uff09\u7684\u53c3\u8207\u8005\u5728\u6700\u5f8c\u4e00\u6b21\u53ef\u8a55\u4f30\u96a8\u8a2a\u4e2dHBV DNA\u4ecd\u4f4e\u65bc\u5b9a\u91cf\u4e0b\u9650\uff08LLOQ\uff09\u3002\u672a\u89c0\u5bdf\u5230ALT\u5feb\u901f\u5347\u9ad8\uff1b\u50c5\u67091\u540d\u53c3\u8207\u8005ALT\u8d85\u51fa\u6b63\u5e38\u7bc4\u570d\uff0c\u7814\u7a76\u8005\u57fa\u65bc\u81e8\u5e8a\u5224\u65b7\u70ba\u5176\u91cd\u65b0\u555f\u52d5NRTI\u6cbb\u7642\u3002 \u95dc\u65bc\u4e59\u578b\u809d\u708e \u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002 \u95dc\u65bcBRII-179 BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u30022023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 \u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u91cd\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u548c\u6cbb\u7642\u9078\u64c7\u6709\u9650\u7684\u9818\u57df\u958b\u767c\u7642\u6cd5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u3002\u516c\u53f8\u6b63\u63a8\u9032\u4e00\u7cfb\u5217\u7368\u7279\u7684\u5019\u9078\u85e5\u7269\u7814\u767c\u7ba1\u7dda\uff0c\u5305\u62ec\u9032\u5c55\u6700\u9818\u5148\u7684\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u5728\u4e2d\u570b\u548c\u7f8e\u570b\u5747\u8a2d\u6709\u904b\u71df\u6a5f\u69cb\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0www.briibio.com\u3002 \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672 \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C. \u00a0","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=430159"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":"3000","height":"1990"},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=430159#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u9a30\u76db\u535a\u85e5\u5728APASL 2026\u767c\u8868\u6cbb\u7642\u7d50\u675f\u5f8cHBsAg\u53cd\u5f48\u7684\u8de8\u7814\u7a76\u5206\u6790\u7d50\u679c"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/430159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=430159"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/430159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/199219"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=430159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=430159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=430159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}