{"id":428754,"date":"2026-04-22T10:00:00","date_gmt":"2026-04-22T02:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=428754"},"modified":"2026-04-22T10:00:00","modified_gmt":"2026-04-22T02:00:00","slug":"%e9%82%81%e5%a8%81%e7%94%9f%e7%89%a9%e9%9d%b6%e5%90%91nectin-4-adc%ef%bc%889mw2821%ef%bc%89%e6%b2%bb%e7%99%82%e5%ae%ae%e9%a0%b8%e7%99%8c%e7%9a%84%e7%97%85%e4%be%8b%e5%a0%b1%e5%91%8a%e7%99%bb%e4%b8%8a","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=428754","title":{"rendered":"\u9081\u5a01\u751f\u7269\u9776\u5411Nectin-4 ADC\uff089MW2821\uff09\u6cbb\u7642\u5bae\u9838\u764c\u7684\u75c5\u4f8b\u5831\u544a\u767b\u4e0a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b"},"content":{"rendered":"
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\u4e0a\u6d77<\/span>2026\u5e744\u670822\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u9081\u5a01\u751f\u7269\uff08688062.SH\uff09\uff0c\u4e00\u5bb6\u5168\u7522\u696d\u93c8\u4f48\u5c40\u7684\u5275\u65b0\u578b\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81ea\u4e3b\u7814\u767c\u7684\u9776\u5411<\/span>Nectin-4 ADC\u5275\u65b0\u85e5\uff08bulumtatug fuvedotin\uff0c\u7814\u767c\u4ee3\u865f\uff1a9MW2821\uff09\u6cbb\u7642\u5bae\u9838\u764c\u7684\u6700\u65b0\u81e8\u5e8a\u75c5\u4f8b\u5831\u9053\u8fd1\u65e5\u767b\u4e0a\u570b\u969b\u9802\u5c16\u91ab\u5b78\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08NEJM\uff0c\u5f71\u97ff\u56e0\u5b50\uff1a78.5\uff09\u3002<\/p>\n

\u8a72\u6587\u7ae0\u7531\u5b9c\u8cd3\u5e02\u7b2c\u4e8c\u4eba\u6c11\u91ab\u9662\u816b\u7624\u4e2d\u5fc3\u6c6a\u5584\u5175\u4e3b\u4efb\u5718\u968a\u767c\u8868\uff0c\u9996\u6b21\u5411\u5168\u7403\u63ed\u793a\u4e86\u665a\u671f\u5bae\u9838\u764c\u60a3\u8005\u5728\u63a5\u53d7\u65b0\u578bNectin-4 ADC\uff089MW2821\uff09\u6cbb\u7642\u5f8c\uff0c\u51fa\u73fe\u7684\u7f55\u898b\u809d\u81df\u300c\u5047\u6027\u9032\u5c55\u300d\u73fe\u8c61\u3002\u300c\u5047\u6027\u9032\u5c55\uff08pseudoprogression\uff09\u300d\u4e00\u822c\u6307\u5728\u514d\u75ab\u6cbb\u7642\u521d\u671f\u816b\u7624\u539f\u6709\u75c5\u7076\u77ed\u671f\u5167\u589e\u5927\u6216\u51fa\u73fe\u65b0\u75c5\u7076\uff0c\u4e0d\u4f34\u6709\u75be\u75c5\u60e1\u5316\uff0c\u5f8c\u671f\u75c5\u7076\u8868\u73fe\u70ba\u7a69\u5b9a\u6216\u7e2e\u5c0f\u7684\u73fe\u8c61\uff0c\u901a\u5e38\u4e26\u975e\u771f\u6b63\u7684\u816b\u7624\u9032\u5c55\u3002<\/p>\n

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ADC\u85e5\u7269\u88ab\u8b7d\u70ba\u7cbe\u6e96\u6253\u64ca\u816b\u7624\u7684\u300c\u9b54\u6cd5\u5b50\u5f48\u300d\u3002\u6b64\u524d\uff0c\u300c\u5047\u6027\u9032\u5c55\u300d\u591a\u898b\u65bcPD-1\/PD-L1\u7b49\u514d\u75ab\u7642\u6cd5\u4e2d\uff0c\u5728\u5be6\u9ad4\u7624\u7684ADC\u6cbb\u7642\u4e2d\u582a\u7a31\u300c\u6975\u70ba\u7f55\u898b\u300d\u3002\u6c6a\u5584\u5175\u4e3b\u4efb\u5718\u968a\u7684\u9019\u4e00\u767c\u73fe\u5c0d\u665a\u671f\u5bae\u9838\u764c\u81e8\u5e8a\u6cbb\u7642\u5177\u6709\u91cd\u8981\u6307\u5c0e\u610f\u7fa9\u3002\u6587\u7ae0\u5f37\u6709\u529b\u5730\u6307\u51fa\uff0c\u5207\u52ff\u76f2\u76ee\u56e0\u5f71\u50cf\u5b78\u300c\u5047\u8c61\u300d\u800c\u904e\u65e9\u505c\u6b62\u53ef\u80fd\u5ef6\u9577\u751f\u547d\u7684\u6cbb\u7642\uff0c<\/span>\u70baADC\u85e5\u7269\u7684\u81e8\u5e8a\u61c9\u7528\u63d0\u4f9b\u4e86\u53c3\u8003\u4f9d\u64da\uff0c\u5207\u5be6\u5b88\u8b77\u816b\u7624\u60a3\u8005\u6700\u4f73\u6cbb\u7642\u7372\u76ca\u3002<\/p>\n

9MW2821 \u662f\u5168\u7403\u9996\u6b3e\u91dd\u5c0d\u5bae\u9838\u764c\u9069\u61c9\u75c7\u9032\u5165III\u671f\u81e8\u5e8a\u7684Nectin-4 ADC\u5275\u65b0\u85e5\u3002\u76ee\u524d\uff0c\u55ae\u85e5\u6cbb\u7642III\u671f\u81e8\u5e8a\u5df2\u5b8c\u6210\u5165\u7d44\uff0c\u8a08\u5283\u65bc2026\u5e74\u4e0b\u534a\u5e74\u9032\u884c\u671f\u4e2d\u5206\u6790\uff0c\u4e26\u6839\u64da\u671f\u4e2d\u5206\u6790\u7d50\u679c\u5411 NMPA CDE \u63d0\u4ea4\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u524d\u6703\u8b70\uff1b\u4e00\u7dda\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u8655\u65bcII\u671f\u81e8\u5e8a\u968e\u6bb5\u3002<\/p>\n

\u95dc\u65bc\u9081\u5a01\u751f\u7269<\/p>\n

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