{"id":420723,"date":"2026-03-25T01:38:00","date_gmt":"2026-03-24T17:38:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=420723"},"modified":"2026-03-25T01:38:00","modified_gmt":"2026-03-24T17:38:00","slug":"%e7%a7%91%e5%80%ab%e5%8d%9a%e6%b3%b0%e5%85%ac%e4%bd%882025%e5%b9%b4%e6%a5%ad%e7%b8%be%ef%bc%9a%e5%a4%9a%e6%ac%be%e7%94%a2%e5%93%81%e6%88%90%e5%8a%9f%e4%b8%8a%e5%b8%82%ef%bc%8c%e9%9a%8e%e6%a2%af","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=420723","title":{"rendered":"\u79d1\u502b\u535a\u6cf0\u516c\u4f482025\u5e74\u696d\u7e3e\uff1a\u591a\u6b3e\u7522\u54c1\u6210\u529f\u4e0a\u5e02\uff0c\u968e\u68af\u5f0f\u7814\u767c\u7ba1\u7dda\u84c4\u52e2\u5f85\u767c"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li>\u71df\u6536\u7d0420.5792\u5104\u5143\uff0c\u6bdb\u5229\u7d0414.7878\u5104\u5143\uff0c\u5be6\u73fe\u540c\u6bd4\u589e\u9577\u3002<\/li>\n<li>\u7814\u767c\u958b\u652f\u7d0413.1968\u5104\u5143\u3002<\/li>\n<li>\u671f\u5167\u8667\u640d3.8197\u5104\u5143\uff0c\u8abf\u6574\u5f8c\u5e74\u5ea6\u8667\u640d<sup>[1]<\/sup>\u7d042.1128\u5104\u5143\u3002<\/li>\n<li>\u73fe\u91d1\u53ca\u91d1\u878d\u8cc7\u7522<sup>[2]<\/sup>\u7d0445.5936\u5104\u5143\uff0c\u73fe\u91d1\u5132\u5099\u5145\u8db3\u3002<\/li>\n<li>\u8cc7\u7522\u8ca0\u50b5\u7387<sup>[3]<\/sup>\u9032\u4e00\u6b65\u964d\u81f318.7%\u3002<\/li>\n<\/ul>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen3\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">1. <\/span><\/i><i><span class=\"prnews_span\">\u901a\u904e\u5f9e\u671f\u5167\u5229\u6f64\u2571\u8667\u640d\u4e2d\u6263\u9664\u4ee5\u6b0a\u76ca\u7d50\u7b97\u7684\u80a1\u4efd\u652f\u4ed8\u8a08\u7b97\u5f97\u51fa\u3002<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen3\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">2. <\/span><\/i><i><span class=\"prnews_span\">\u5305\u62ec\u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269\u3001\u53d7\u9650\u5b58\u6b3e\u3001\u6309\u516c\u5141\u50f9\u503c\u8a08\u91cf\u4e14\u5176\u8b8a\u52d5\u8a08\u5165\u7576\u671f\u640d\u76ca\u7684\u91d1\u878d\u8cc7\u7522\u4ee5\u53ca\u6309\u6524\u4f59\u6210\u672c\u8a08\u91cf\u7684\u91d1\u878d\u8cc7\u7522\u3002<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prngen3\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">3. <\/span><\/i><i><span class=\"prnews_span\">\u6309\u7e3d\u8ca0\u50b5\u9664\u4ee5\u7e3d\u8cc7\u7522\u8a08\u7b97<\/span><\/i><i><span class=\"prnews_span\">\u5f97\u51fa<\/span><\/i><i><span class=\"prnews_span\">\u3002<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p id=\"temp_ReleaseStart\"><span class=\"legendSpanClass\">\u6210\u90fd<\/span><span class=\"legendSpanClass\">2026\u5e743\u670825\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u79d1\u502b\u535a\u6cf0\u300d\u6216\u300c\u8a72\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK\uff09\u516c\u4f48\u5176\u622a\u81f32025\u5e7412\u670831\u65e5\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u5831\u544a\u671f\u300d\uff09\u7684\u5e74\u5ea6\u7d93\u5be9\u6838\u5408\u4f75\u696d\u7e3e\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p class=\"prntaj\">\u79d1\u502b\u535a\u6cf0\u6b63\u6191\u501f\u5176\u6838\u5fc3\u512a\u52e2\u548c\u5c08\u6709\u7684OptiDC\u2122\u6280\u8853\u5e73\u53f0\uff0c\u6301\u7e8c\u6df1\u8015\u6297\u9ad4\u5076\u806f\u85e5\u7269(ADC)\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269(DC)\u9818\u57df\u3002\u516c\u53f8\u7a4d\u6975\u63a8\u9032\u5305\u62ec\u96d9\u7279\u7570\u6027ADC\u3001\u653e\u5c04\u6027\u6838\u7d20\u5076\u806f\u85e5\u7269(RDC)\u3001\u514d\u75ab\u523a\u6fc0ADC (iADC)\u53ca\u964d\u89e3\u6297\u9ad4\u5076\u806f\u85e5\u7269(DAC)\u7b49\u524d\u6cbf\u85e5\u7269\u5f62\u5f0f\uff0c\u8457\u529b\u69cb\u5efa\u5177\u6709\u5f37\u5927\u5168\u7403\u7af6\u722d\u529b\u7684\u5dee\u7570\u5316\u7814\u767c\u7ba1\u7dda\u3002\u540c\u6642\uff0c\u79d1\u502b\u535a\u6cf0\u7a69\u6b65\u63a8\u9032\u7522\u54c1\u5546\u696d\u5316\u9032\u7a0b\uff0c\u5be6\u73fe\u696d\u52d9\u8f49\u578b\u589e\u9577\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5df2\u6709\u56db\u6b3e\u7522\u54c1\uff08\u5171\u8986\u84cb8\u500b\u9069\u61c9\u75c7\uff09\u5728\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5305\u62ec\u6ce8\u5c04\u7528\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\uff08\u4f73\u6cf0\u840aR\uff09\u3001\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\uff08\u8212\u6cf0\u840aR\uff09\u3001\u5854\u6208\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u79d1\u6cf0\u840aR\uff09\u548c\u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\uff08\u9054\u6cf0\u840aR\uff09\u3002\u5176\u4e2d\uff0c\u4e09\u6b3e\u7522\u54c1\uff08\u5171\u8986\u84cb5\u500b\u9069\u61c9\u75c7\uff09\u5df2\u88ab\u7d0d\u51652025\u5e74\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u69cb\u5efa\u8d77\u8986\u84cb\u7814\u767c\u81f3\u5546\u696d\u5316\u7684\u5168\u93c8\u689d\u85e5\u7269\u958b\u767c\u751f\u614b\u7cfb\u7d71\u3002<\/p>\n<p class=\"prntaj\">\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5df2\u69cb\u5efa\u8d77\u5305\u542b30\u9918\u6b3e\u5728\u7814\u85e5\u7269\u7684\u5f37\u5927\u7814\u767c\u7ba1\u7dda\uff0c\u5176\u4e2d10\u9918\u6b3e\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\uff0c\u4e26\u9010\u6b65\u62d3\u5c55\u81f3\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u4ee3\u8b1d\u6027\u75be\u75c5\u7b49\u66f4\u5ee3\u6cdb\u7684\u975e\u816b\u7624\u6cbb\u7642\u9818\u57df\u3002\u5c55\u671b\u672a\u4f86\uff0c\u516c\u53f8\u5c07\u4f9d\u6258\u5176\u5275\u65b0\u4e14\u5dee\u7570\u5316\u7684\u7814\u767c\u7ba1\u7dda\uff0c\u70ba\u5168\u7403\u5c1a\u672a\u6eff\u8db3\u7684\u91cd\u5927\u91ab\u7642\u9700\u6c42\u63d0\u4f9b\u9ad8\u8cea\u91cf\u7684\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n<p class=\"prntaj\"><b>\u6838\u5fc3<\/b><b>ADC<\/b><b>\u7522\u54c1\u5546\u696d\u5316\u843d\u5730\uff0c\u592f\u5be6\u9577\u671f\u696d\u7e3e\u57fa\u790e<\/b><\/p>\n<p class=\"prntaj\"><b>\u6ce8\u5c04\u7528\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\uff08<\/b>s<b>ac-TMT<\/b><b>\uff0c<\/b><b>TROP2 ADC<\/b><b>\uff09\uff08\u4ea6\u7a31<\/b><b>SKB264\/MK-2870<\/b><b>\uff09\uff08<\/b><b>\u5546\u54c1\u540d\uff1a<\/b><b>\u4f73\u6cf0\u840a<\/b><b><sup>R<\/sup><\/b><b>\uff09<\/b><\/p>\n<p class=\"prntaj\"><b>\u4e09\u9670\u6027\u4e73\u817a\u764c\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6\uff0c\u5728\u4e2d\u570b\u4f7f\u7528sac-TMT\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c112\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002<\/li>\n<li>\u516c\u53f8\u5df2\u555f\u52d5\u4e00\u9805\u91dd\u5c0dsac-TMT\u55ae\u85e5\u5c0d\u6bd4ICC\uff08\u7814\u7a76\u8005\u9078\u64c7\u7684\u5316\u7642\uff09\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u4e09\u9670\u6027\u4e73\u817a\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>HR+\/HER2-<\/b><b>\u4e73\u817a\u764c\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>2026\u5e742\u6708\uff0csac-TMT\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u65b9\u6848\u7684HR+\/HER2-\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002<\/li>\n<li>\u4e00\u9805\u91dd\u5c0dsac-TMT\u5c0d\u6bd4ICC\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>EGFR<\/b><b>\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>2025\u5e743\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u548c\u9251\u985e\u5316\u7642\u5931\u6557\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u7528\u65bc\u80ba\u764c\u6cbb\u7642\u7684TROP2 ADC\u85e5\u7269\u3002<\/li>\n<li>2025\u5e7410\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u76f8\u6bd4\u542b\u9251\u96d9\u85e5\u5316\u7642\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f\u7372\u76ca\uff0c\u4e14\u7372\u6279\u7528\u65bc\u50c5\u63a5\u53d7TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08\u4e8c\u7dda\u6cbb\u7642\uff09\u7684ADC\u85e5\u7269\u3002<\/li>\n<li>\u4e00\u9805sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9805sac-TMT\u55ae\u85e5\u6216\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4f5c\u70baEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u65b0\u8f14\u52a9\u6cbb\u7642\u76842\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>EGFR<\/b><b>\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u4e00\u9805sac-TMT\u806f\u5408KEYTRUDAR<sup>[1]<\/sup>\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u5df2\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\u3002\u9019\u662f\u9996\u500b\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684ADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u76843\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/li>\n<li>2026\u5e741\u6708\uff0csac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/li>\n<li>\u4e00\u9805sac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u9670\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>\u5176\u4ed6\u9069\u61c9\u75c7\uff1a<\/b>\u516c\u53f8\u6b63\u7a4d\u6975\u63a2\u7d22sac-TMT\u55ae\u85e5\u53ca\u806f\u5408\u5176\u4ed6\u7642\u6cd5\u5728\u6cbb\u7642\u5176\u4ed6\u5be6\u9ad4\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u5bae\u9838\u764c\u3001\u5375\u5de2\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u53bb\u52e2\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u3001\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u3001\u7532\u72c0\u817a\u764c\u7b49\uff09\u65b9\u9762\u7684\u6f5b\u529b\u3002<\/p>\n<p class=\"prntaj\"><b>\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297<\/b><b>(HER2 ADC)<\/b><b>\uff08\u4ea6\u7a31<\/b><b>A166<\/b><b>\uff09\uff08<\/b><b>\u5546\u54c1\u540d\uff1a<\/b><b>\u8212\u6cf0\u840a<\/b><b>R<\/b><b>\uff09<\/b><\/p>\n<ul type=\"disc\">\n<li>2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002<\/li>\n<li>\u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>\u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a<\/b><\/p>\n<ul type=\"disc\">\n<li>sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002<\/li>\n<li>sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002<\/li>\n<li>sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002<\/li>\n<li>\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>\u5728\u7814<\/b><b>ADC<\/b><b>\u85e5\u7269<\/b><b>\u6301\u7e8c\u91cb\u653e\u50f9\u503c\uff0c\u5275\u65b0<\/b><b>\u7814\u767c<\/b><b>\u7ba1\u7dda\u968e\u68af\u63a8\u9032<\/b><\/p>\n<p class=\"prntaj\"><b><i><u>2<\/u><\/i><\/b><b><i><u>\u671f\u81e8\u5e8a\u968e\u6bb5<\/u><\/i><\/b><\/p>\n<p class=\"prntaj\"><b>SKB315 (CLDN18.2 ADC)<\/b><b>\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>SKB315\u76841b\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u7528\u65bc\u6cbb\u7642\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\/\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u7b49\u3002<\/li>\n<li>SKB315\u6cbb\u7642\u5305\u62ec\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u76841\u671f\u7814\u7a76\u7d50\u679c\u65bc2025\u5e7410\u6708\u57282025\u5e74ESMO\u5927\u6703\u4e0a\u767c\u5e03\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>SKB410\/MK-3120 (Nectin-4 ADC)<\/b><b>\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5408\u4f5c\u5925\u4f34\u9ed8\u6c99\u6771(MSD)\u5df2\u555f\u52d5\u4e864\u9805SKB410\/MK-3120\u9776\u5411\u8180\u80f1\u764c\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u7684\u5168\u74031\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>SKB571\/MK-2750<\/b><b>\uff08\u65b0\u578b\u96d9\u6297<\/b><b>ADC<\/b><b>\uff09\uff1a<\/b>2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002<\/p>\n<p class=\"prntaj\"><b>SKB518<\/b><b>\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578b<\/b><b>ADC<\/b><b>\uff09\uff1a<\/b>2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002<\/p>\n<p class=\"prntaj\"><b>SKB500<\/b><b>\uff08\u65b0\u578b<\/b><b>ADC<\/b><b>\uff09\uff1a<\/b>2\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002<\/p>\n<p class=\"prntaj\"><b><i><u>1<\/u><\/i><\/b><b><i><u>\u671f\u81e8\u5e8a\u968e\u6bb5<\/u><\/i><\/b><\/p>\n<p class=\"prntaj\"><b>SKB107 (RDC)<\/b>\u00a0<b><sup>[2]<\/sup><\/b><b>\uff1a<\/b>1\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002<\/p>\n<p class=\"prntaj\"><b>SKB535\/MK-6204<\/b><b>\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578b<\/b><b>ADC<\/b><b>\uff09\uff1a<\/b>SKB535\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002<\/p>\n<p class=\"prntaj\"><b>SKB445<\/b><b>\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578b<\/b><b>ADC<\/b><b>\uff09\uff1a<\/b>SKB445\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002<\/p>\n<p class=\"prntaj\"><b>SKB105\/CR-003 (ITGB6 ADC)<\/b><b>\uff1a<\/b>2026\u5e741\u6708\uff0c\u8a72\u85e5\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u6279\u51c6\u3002\u4e00\u98051\/2\u671f\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002<\/p>\n<p class=\"prntaj\"><b>\u975e<\/b><b>ADC<\/b><b>\u8cc7\u7522\u6230\u7565\u4f48\u5c40\uff0c\u805a\u7126\u806f\u5408\u7642\u6cd5\u8207\u9069\u61c9\u75c7\u62d3\u5c55<\/b><\/p>\n<p class=\"prntaj\"><b><i><u>\u816b\u7624\u9818\u57df\u5019\u9078\u85e5\u7269<\/u><\/i><\/b><\/p>\n<ul type=\"disc\">\n<li><b>\u5854\u6208\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08<\/b><b>PD-L1<\/b><b>\u55ae\u6297\uff0c\u4ea6\u7a31<\/b><b>A167<\/b><b>\uff09\uff08<\/b><b>\u5546\u54c1\u540d\uff1a<\/b><b>\u79d1\u6cf0\u840a<\/b><b>R<\/b><b>\uff09\uff1a<\/b>2025\u5e741\u6708\uff0c\u8a72\u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\uff0c\u5c07\u5854\u6208\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u3002\u5854\u6208\u5229\u55ae\u6297\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u7684PD-L1\u55ae\u6297\u3002<\/li>\n<li>2025\u5e745\u6708\uff0c\u5854\u6208\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5728ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>\u897f\u59a5\u6614\u55ae\u6297<\/b><b>N01<\/b><b>\u6ce8\u5c04\u6db2\uff08<\/b><b>EGFR<\/b><b>\u55ae\u6297\uff0c\u4ea6\u7a31<\/b><b>A140<\/b><b>\uff09\uff08\u5546\u54c1\u540d\uff1a\u9054\u6cf0\u840a<\/b><b>R<\/b><b>\uff09\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>2025\u5e742\u6708\uff0c\u8a72\u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\uff0c\u5c07\u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\u806f\u5408FOLFOX\u6216FOLFIRI\u65b9\u6848\u7528\u65bcRAS\u57fa\u56e0\u91ce\u751f\u578b\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u81a0\u56ca\uff08<\/b><b>RET<\/b><b>\u6291\u5236\u5291\uff0c\u4ea6\u7a31<\/b><b>A400\/EP0031<\/b><b>\uff09\uff08\u5546\u54c1\u540d\uff1a\u5be7\u6cf0\u840a<\/b><b>R<\/b><b>\uff09<\/b><b><sup>[3]<\/sup><\/b><b>\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u7528\u65bc\u4e00\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u53d7\u7406\u3002<\/li>\n<li>\u8a72\u516c\u53f8\u9084\u5728\u4e2d\u570b\u958b\u5c55\u91dd\u5c0dRET\u967d\u6027\u7532\u72c0\u817a\u9ad3\u6a23\u764c\u53ca\u5be6\u9ad4\u7624\u76841b\/2\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/li>\n<li>Ellipses Pharma\u6b63\u5728\u4e2d\u570b\u4ee5\u5916\u7684\u5730\u5340\u63a8\u9032\u51762\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/li>\n<li>2025\u5e745\u6708\uff0c\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u81a0\u56ca\u6cbb\u7642\u665a\u671fRET\u7a81\u8b8a\u578b\u7532\u72c0\u817a\u9ad3\u6a23\u764c\u76841\u671f\u7814\u7a76\u7d50\u679c\u5728ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>SKB118\/CR-001<\/b><b>\uff08<\/b><b>PD-1\/VEGF<\/b><b>\u96d9\u6297\uff09\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>2026\u5e741\u6708\uff0cCrescent Biopharma\u5ba3\u4f48\u5176\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684SKB118\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372FDA\u6279\u51c6\uff0c\u555f\u52d5\u5168\u7403ASCEND 1\/2\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u9996\u4f8b\u60a3\u8005\u5df2\u65bc2026\u5e742\u6708\u7d66\u85e5\u3002<\/li>\n<li>\u516c\u53f8\u8a08\u5283\u65bc2026\u5e74\u4e0a\u534a\u5e74\u5728\u4e2d\u570b\u555f\u52d5SKB118\u76841\/2\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b><i><u>\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u9818\u57df\u5019\u9078\u85e5\u7269<\/u><\/i><\/b><\/p>\n<p class=\"prntaj\"><b>SKB378\/WIN378<\/b><b>\uff08<\/b><b>TSLP<\/b><b>\u55ae\u6297\uff09\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>2025\u5e741\u6708\uff0cSKB378\u7528\u65bc\u6cbb\u7642\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002<\/li>\n<li>\u5408\u4f5c\u5925\u4f34Windward Bio\u5df2\u555f\u52d5\u91dd\u5c0d\u54ee\u5598\u60a3\u8005\u76842\u671fPOLARIS\u5168\u7403\u8a66\u9a57\u3002<\/li>\n<\/ul>\n<p class=\"prntaj\"><b>SKB575<\/b><b>\uff08<\/b><b>TSLP\/<\/b><b>\u672a\u62ab\u9732\u9776\u9ede\u96d9\u6297\uff09\uff1a<\/b>2026\u5e743\u6708\uff0cSKB575\u7528\u65bc\u6cbb\u7642\u7279\u61c9\u6027\u76ae\u708e\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002<\/p>\n<p class=\"prntaj\"><b><i><u>\u5176\u4ed6\u975e\u816b\u7624\u75be\u75c5\u9818\u57df\u5019\u9078\u85e5\u7269<\/u><\/i><\/b><\/p>\n<p class=\"prntaj\"><b>SKB336<\/b><b>\uff08<\/b><b>FXI\/FXIa<\/b><b>\u55ae\u6297\uff09\uff1a<\/b>\u516c\u53f8\u5df2\u5b8c\u6210\u5728\u4e2d\u570b\u958b\u5c55\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n<p class=\"prntaj\"><b>\u591a\u6b3e\u7522\u54c1\u9996\u6b21\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff0c\u5e02\u5834\u8986\u84cb\u52a0\u901f<\/b><\/p>\n<p class=\"prntaj\">2025\u5e74\uff0c\u516c\u53f8\u5275\u65b0\u6210\u679c\u5546\u696d\u5316\u5448\u73fe\u7206\u767c\u5f0f\u589e\u9577\u3002\u516c\u53f8\u9084\u63d0\u4ea4\u4e86\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u81a0\u56ca\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff0c\u9810\u8a08\u57282026\u5e74\u4e0b\u534a\u5e74\u62162027\u5e74\u4e0a\u534a\u5e74\u555f\u52d5\u5546\u696d\u5316\uff0c\u5177\u9ad4\u53d6\u6c7a\u65bc\u76e3\u7ba1\u6e9d\u901a\u548c\u4e0a\u5e02\u6279\u51c6\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u7531\u4e94\u6b3e\u7522\u54c1\u7d44\u6210\u7684\u521d\u671f\u5546\u696d\u5316\u7522\u54c1\u7d44\u5408\u5df2\u521d\u5177\u898f\u6a21\u3002<\/p>\n<p class=\"prntaj\">\u5728\u570b\u5bb6\u5275\u65b0\u653f\u7b56\u652f\u6301\u4e0b\uff0c\u8a72\u516c\u53f8\u6210\u529f\u63a8\u52d5\u4e09\u6b3e\u5546\u696d\u5316\u7522\u54c1\u4f73\u6cf0\u840aR\u3001\u79d1\u6cf0\u840aR\u53ca\u9054\u6cf0\u840aR\u9996\u6b21\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u4e26\u65bc2026\u5e741\u67081\u65e5\u6b63\u5f0f\u751f\u6548\uff0c\u6709\u671b\u66f4\u5feb\u66f4\u597d\u5730\u60e0\u53ca\u66f4\u591a\u60a3\u8005\u3002<\/p>\n<p class=\"prntaj\"><b>\u5168\u7403\u5408\u4f5c\u7a69\u6b65\u63a8\u9032\uff0c\u7d9c\u5408\u5be6\u529b\u7372\u6b0a\u5a01\u8a8d\u53ef<\/b><\/p>\n<p class=\"prntaj\"><b>\u8207\u9ed8\u6c99\u6771\u5408\u4f5c\uff1a<\/b>\u622a\u81f3\u672c\u516c\u544a\u65e5\u671f\uff0c\u9ed8\u6c99\u6771\u6b63\u5728\u8a55\u4f30\u5df2\u555f\u52d5\u768417\u9805sac-TMT\u4f5c\u70ba\u55ae\u85e5\u6216\u8207\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u85e5\u7269\u806f\u5408\u7528\u85e5\uff0c\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u764c\u75c7\uff08\u5305\u62ec\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u5a66\u79d1\u816b\u7624\u3001\u6d88\u5316\u9053\u816b\u7624\u53ca\u6ccc\u5c3f\u7cfb\u7d71\u816b\u7624\uff09\u76843\u671f\u5168\u7403\u81e8\u5e8a\u7814\u7a76\u3002\u9664sac-TMT\u5916\uff0c\u8a72\u516c\u53f8\u4ea6\u8207\u9ed8\u6c99\u6771\u5c31\u90e8\u5206ADC\u8cc7\u7522\u5c55\u958b\u5408\u4f5c\uff0c\u6301\u7e8c\u63a2\u7d22\u6709\u512a\u52e2\u7684ADC\u7ba1\u7dda\u7d44\u5408\u3002<\/p>\n<p class=\"prntaj\"><b>\u8207<\/b><b>Ellipses Pharma<\/b><b>\u5408\u4f5c\uff1a<\/b>\u516c\u53f8\u6df1\u5316\u4e86\u8207Ellipses Pharma\u5728A400\/EP0031\u4e0a\u7684\u5408\u4f5c\uff0c\u8a72\u85e5\u5df2\u7372FDA\u6279\u51c6\u9032\u51652\u671f\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\u3002\u622a\u81f32025\u5e7412\u670831\u65e5\uff0c\u5df2\u5728\u7f8e\u570b\u3001\u6b50\u6d32\u53ca\u963f\u806f\u914b\u70ba\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u81a0\u56ca\u8a2d\u7acb\u4e8639\u500b\u81e8\u5e8a\u7814\u7a76\u4e2d\u5fc3\u3002<\/p>\n<p class=\"prntaj\"><b>\u8207<\/b><b>Windward Bio<\/b><b>\u5408\u4f5c\uff1a<\/b>2025\u5e741\u6708\uff0c\u8a72\u516c\u53f8\u53ca\u548c\u9251\u91ab\u85e5\u8207Windward Bio\u7c3d\u8a02\u7368\u5bb6\u8a31\u53ef\u5354\u8b70\uff0c\u64da\u6b64\uff0c\u8a72\u516c\u53f8\u8207\u548c\u9251\u91ab\u85e5\u6388\u4e88Windward Bio\u5728\u5168\u7403\u7bc4\u570d\u5167\uff08\u4e0d\u5305\u62ec\u5927\u4e2d\u83ef\u5340\u53ca\u90e8\u5206\u6771\u5357\u4e9e\u548c\u897f\u4e9e\u570b\u5bb6\uff09\u7814\u7a76\u3001\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316SKB378\/WIN378\u7684\u7368\u5bb6\u8a31\u53ef\u3002Windward Bio\u5df2\u555f\u52d5\u91dd\u5c0d\u54ee\u5598\u60a3\u8005\u76842\u671fPOLARIS\u5168\u7403\u8a66\u9a57\u3002<\/p>\n<p class=\"prntaj\"><b>\u8207<\/b><b>Crescent Biopharma<\/b><b>\u5408\u4f5c\uff1a<\/b>2025\u5e7412\u6708\uff0c\u8a72\u516c\u53f8\u8207Crescent Biopharma\u5c31SKB105\/CR-003\u53caSKB118\uff08\u4e00\u7a2ePD1 x VEGF\u96d9\u6297\uff0c\u4ea6\u7a31CR-001\uff09\u9054\u6210\u6230\u7565\u5408\u4f5c\u3002\u6839\u64da\u5408\u4f5c\uff0c\u8a72\u516c\u53f8\u6388\u4e88Crescent Biopharma\u5728\u7f8e\u570b\u3001\u6b50\u6d32\u53ca\u5927\u4e2d\u83ef\u5340\u4ee5\u5916\u7684\u6240\u6709\u5176\u4ed6\u5e02\u5834\u7814\u7a76\u3001\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316SKB105\/CR-003\u7684\u7368\u5bb6\u6b0a\u5229\u3002\u4f5c\u70ba\u56de\u5831\uff0c\u516c\u53f8\u5f9eCrescent Biopharma\u7372\u5f97\u5728\u5927\u4e2d\u83ef\u5340\u7814\u7a76\u3001\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316SKB118\/CR-001\u7684\u7368\u5bb6\u6b0a\u5229\u3002<\/p>\n<p class=\"prntaj\">2026\u5e741\u6708\uff0cCrescent Biopharma\u5ba3\u4f48\u5176\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684SKB118\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372FDA\u6279\u51c6\uff0c\u555f\u52d5\u5168\u7403ASCEND 1\/2\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u9996\u4f8b\u60a3\u8005\u5df2\u65bc2026\u5e742\u6708\u7d66\u85e5\u3002<\/p>\n<p class=\"prntaj\"><b>ESG<\/b><b>\u80fd\u529b\u6301\u7e8c\u63d0\u5347\uff0c\u7bc9\u7262\u53ef\u6301\u7e8c\u767c\u5c55\u6839\u57fa<\/b><\/p>\n<p class=\"prntaj\">\u8a72\u516c\u53f8\u901a\u904e\u5efa\u7acb\u4e26\u4e0d\u65b7\u5b8c\u5584ESG\u6cbb\u7406\u7d50\u69cb\uff0c\u5168\u9762\u63d0\u5347ESG\u7e3e\u6548\u80fd\u529b\uff0c\u78ba\u4fdd\u516c\u53f8\u53ef\u6301\u7e8c\u767c\u5c55\u30022025\u5e745\u6708\uff0c\u8a72\u516c\u53f8\u69ae\u7372Extel\u300c\u6700\u4f73ESG\u300d\u734e\u30022026\u5e743\u6708\uff0c\u516c\u53f8\u5728MSCI ESG\u8a55\u7d1a\u8a55\u4f30\u4e2d\u7372\u5f97\u300cAA\u300d\u8a55\u7d1a\u3002<\/p>\n<p class=\"prntaj\"><b>\u5c55\u671b<\/b><\/p>\n<p class=\"prntaj\">2026\u5e74\uff0c\u79d1\u502b\u535a\u6cf0\u5c07\u7e7c\u7e8c\u63a8\u52d5\u5275\u65b0\uff0c\u5f37\u5316\u904b\u71df\u80fd\u529b\uff0c\u671d\u8457\u4e16\u754c\u4e00\u6d41\u751f\u7269\u88fd\u85e5\u516c\u53f8\u7684\u76ee\u6a19\u7a69\u6b65\u9081\u9032\u3002\u5177\u9ad4\u800c\u8a00\uff0c\u516c\u53f8\u5c07\u5be6\u65bd\u4ee5\u4e0b\u767c\u5c55\u6230\u7565\uff1a\u63a8\u9032\u91dd\u5c0d\u5177\u6709\u91cd\u5927\u91ab\u7642\u9700\u6c42\u9069\u61c9\u75c7\u7684\u5dee\u7570\u5316\u7814\u767c\u7ba1\u7dda\uff1b\u5275\u65b0\u548c\u512a\u5316\u6bd2\u7d20-\u9023\u63a5\u5b50\u7b56\u7565\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u8a2d\u8a08\u8207\u7d50\u69cb\uff0c\u540c\u6642\u62d3\u5c55\u975e\u816b\u7624\u75be\u75c5\u9818\u57df\u7684\u61c9\u7528\uff1b\u589e\u5f37\u7aef\u5230\u7aef\u7684\u85e5\u7269\u958b\u767c\u548c\u5546\u696d\u5316\u80fd\u529b\uff1b\u62d3\u5c55\u696d\u52d9\u7248\u5716\u53ca\u6230\u7565\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\uff0c\u63d0\u5347\u516c\u53f8\u5728\u6d77\u5916\u5e02\u5834\u7684\u958b\u767c\u3001\u8a3b\u518a\u53ca\u5546\u696d\u5316\u80fd\u529b\uff1b\u512a\u5316\u904b\u71df\u9ad4\u7cfb\uff0c\u81f4\u529b\u6210\u70ba\u5168\u7403\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\u3002<\/p>\n<p class=\"prntaj\"><b><u>\u95dc\u65bc\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/u><\/b><\/p>\n<p 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2026\u5e742\u6708\uff0csac-TMT\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u65b9\u6848\u7684HR+\/HER2-\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002  \u4e00\u9805\u91dd\u5c0dsac-TMT\u5c0d\u6bd4ICC\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   2025\u5e743\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u548c\u9251\u985e\u5316\u7642\u5931\u6557\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u7528\u65bc\u80ba\u764c\u6cbb\u7642\u7684TROP2 ADC\u85e5\u7269\u3002  2025\u5e7410\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u76f8\u6bd4\u542b\u9251\u96d9\u85e5\u5316\u7642\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f\u7372\u76ca\uff0c\u4e14\u7372\u6279\u7528\u65bc\u50c5\u63a5\u53d7TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08\u4e8c\u7dda\u6cbb\u7642\uff09\u7684ADC\u85e5\u7269\u3002  \u4e00\u9805sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9805sac-TMT\u55ae\u85e5\u6216\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4f5c\u70baEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u65b0\u8f14\u52a9\u6cbb\u7642\u76842\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   \u4e00\u9805sac-TMT\u806f\u5408KEYTRUDAR\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u5df2\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\u3002\u9019\u662f\u9996\u500b\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684ADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u76843\u671f\u81e8\u5e8a\u8a66\u9a57\u3002  2026\u5e741\u6708\uff0csac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002  \u4e00\u9805sac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u9670\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  \u5176\u4ed6\u9069\u61c9\u75c7\uff1a\u516c\u53f8\u6b63\u7a4d\u6975\u63a2\u7d22sac-TMT\u55ae\u85e5\u53ca\u806f\u5408\u5176\u4ed6\u7642\u6cd5\u5728\u6cbb\u7642\u5176\u4ed6\u5be6\u9ad4\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u5bae\u9838\u764c\u3001\u5375\u5de2\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u53bb\u52e2\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u3001\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u3001\u7532\u72c0\u817a\u764c\u7b49\uff09\u65b9\u9762\u7684\u6f5b\u529b\u3002 \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297(HER2 ADC)\uff08\u4ea6\u7a31A166\uff09\uff08\u5546\u54c1\u540d\uff1a\u8212\u6cf0\u840aR\uff09   2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002  \u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  \u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a   sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  \u5728\u7814ADC\u85e5\u7269\u6301\u7e8c\u91cb\u653e\u50f9\u503c\uff0c\u5275\u65b0\u7814\u767c\u7ba1\u7dda\u968e\u68af\u63a8\u9032 2\u671f\u81e8\u5e8a\u968e\u6bb5 SKB315 (CLDN18.2 ADC)\uff1a   SKB315\u76841b\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u7528\u65bc\u6cbb\u7642\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\/\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u7b49\u3002  SKB315\u6cbb\u7642\u5305\u62ec\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u76841\u671f\u7814\u7a76\u7d50\u679c\u65bc2025\u5e7410\u6708\u57282025\u5e74ESMO\u5927\u6703\u4e0a\u767c\u5e03\u3002  SKB410\/MK-3120 (Nectin-4 ADC)\uff1a   \u5408\u4f5c\u5925\u4f34\u9ed8\u6c99\u6771(MSD)\u5df2\u555f\u52d5\u4e864\u9805SKB410\/MK-3120\u9776\u5411\u8180\u80f1\u764c\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u7684\u5168\u74031\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u3002  SKB571\/MK-2750\uff08\u65b0\u578b\u96d9\u6297ADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB518\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB500\uff08\u65b0\u578bADC\uff09\uff1a2\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 1\u671f\u81e8\u5e8a\u968e\u6bb5 SKB107 (RDC)\u00a0\uff1a1\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 SKB535\/MK-6204\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB535\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB445\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB445\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB105\/CR-003 (ITGB6 ADC)\uff1a2026\u5e741\u6708\uff0c\u8a72\u85e5\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u6279\u51c6\u3002\u4e00\u98051\/2\u671f\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 \u975eADC\u8cc7\u7522\u6230\u7565\u4f48\u5c40\uff0c\u805a\u7126\u806f\u5408\u7642\u6cd5\u8207\u9069\u61c9\u75c7\u62d3\u5c55 \u816b\u7624\u9818\u57df\u5019\u9078\u85e5\u7269   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content=\"\u79d1\u502b\u535a\u6cf0\u516c\u4f482025\u5e74\u696d\u7e3e\uff1a\u591a\u6b3e\u7522\u54c1\u6210\u529f\u4e0a\u5e02\uff0c\u968e\u68af\u5f0f\u7814\u767c\u7ba1\u7dda\u84c4\u52e2\u5f85\u767c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u71df\u6536\u7d0420.5792\u5104\u5143\uff0c\u6bdb\u5229\u7d0414.7878\u5104\u5143\uff0c\u5be6\u73fe\u540c\u6bd4\u589e\u9577\u3002  \u7814\u767c\u958b\u652f\u7d0413.1968\u5104\u5143\u3002  \u671f\u5167\u8667\u640d3.8197\u5104\u5143\uff0c\u8abf\u6574\u5f8c\u5e74\u5ea6\u8667\u640d\u7d042.1128\u5104\u5143\u3002  \u73fe\u91d1\u53ca\u91d1\u878d\u8cc7\u7522\u7d0445.5936\u5104\u5143\uff0c\u73fe\u91d1\u5132\u5099\u5145\u8db3\u3002  \u8cc7\u7522\u8ca0\u50b5\u7387\u9032\u4e00\u6b65\u964d\u81f318.7%\u3002           1. \u901a\u904e\u5f9e\u671f\u5167\u5229\u6f64\u2571\u8667\u640d\u4e2d\u6263\u9664\u4ee5\u6b0a\u76ca\u7d50\u7b97\u7684\u80a1\u4efd\u652f\u4ed8\u8a08\u7b97\u5f97\u51fa\u3002        2. 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(iADC)\u53ca\u964d\u89e3\u6297\u9ad4\u5076\u806f\u85e5\u7269(DAC)\u7b49\u524d\u6cbf\u85e5\u7269\u5f62\u5f0f\uff0c\u8457\u529b\u69cb\u5efa\u5177\u6709\u5f37\u5927\u5168\u7403\u7af6\u722d\u529b\u7684\u5dee\u7570\u5316\u7814\u767c\u7ba1\u7dda\u3002\u540c\u6642\uff0c\u79d1\u502b\u535a\u6cf0\u7a69\u6b65\u63a8\u9032\u7522\u54c1\u5546\u696d\u5316\u9032\u7a0b\uff0c\u5be6\u73fe\u696d\u52d9\u8f49\u578b\u589e\u9577\u3002\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f8\u5df2\u6709\u56db\u6b3e\u7522\u54c1\uff08\u5171\u8986\u84cb8\u500b\u9069\u61c9\u75c7\uff09\u5728\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5305\u62ec\u6ce8\u5c04\u7528\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297\uff08\u4f73\u6cf0\u840aR\uff09\u3001\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\uff08\u8212\u6cf0\u840aR\uff09\u3001\u5854\u6208\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u79d1\u6cf0\u840aR\uff09\u548c\u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\uff08\u9054\u6cf0\u840aR\uff09\u3002\u5176\u4e2d\uff0c\u4e09\u6b3e\u7522\u54c1\uff08\u5171\u8986\u84cb5\u500b\u9069\u61c9\u75c7\uff09\u5df2\u88ab\u7d0d\u51652025\u5e74\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u69cb\u5efa\u8d77\u8986\u84cb\u7814\u767c\u81f3\u5546\u696d\u5316\u7684\u5168\u93c8\u689d\u85e5\u7269\u958b\u767c\u751f\u614b\u7cfb\u7d71\u3002 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2025\u5e743\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u548c\u9251\u985e\u5316\u7642\u5931\u6557\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u7528\u65bc\u80ba\u764c\u6cbb\u7642\u7684TROP2 ADC\u85e5\u7269\u3002  2025\u5e7410\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u76f8\u6bd4\u542b\u9251\u96d9\u85e5\u5316\u7642\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f\u7372\u76ca\uff0c\u4e14\u7372\u6279\u7528\u65bc\u50c5\u63a5\u53d7TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08\u4e8c\u7dda\u6cbb\u7642\uff09\u7684ADC\u85e5\u7269\u3002  \u4e00\u9805sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9805sac-TMT\u55ae\u85e5\u6216\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4f5c\u70baEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u65b0\u8f14\u52a9\u6cbb\u7642\u76842\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   \u4e00\u9805sac-TMT\u806f\u5408KEYTRUDAR\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u5df2\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\u3002\u9019\u662f\u9996\u500b\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684ADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u76843\u671f\u81e8\u5e8a\u8a66\u9a57\u3002  2026\u5e741\u6708\uff0csac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002  \u4e00\u9805sac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u9670\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  \u5176\u4ed6\u9069\u61c9\u75c7\uff1a\u516c\u53f8\u6b63\u7a4d\u6975\u63a2\u7d22sac-TMT\u55ae\u85e5\u53ca\u806f\u5408\u5176\u4ed6\u7642\u6cd5\u5728\u6cbb\u7642\u5176\u4ed6\u5be6\u9ad4\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u5bae\u9838\u764c\u3001\u5375\u5de2\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u53bb\u52e2\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u3001\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u3001\u7532\u72c0\u817a\u764c\u7b49\uff09\u65b9\u9762\u7684\u6f5b\u529b\u3002 \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297(HER2 ADC)\uff08\u4ea6\u7a31A166\uff09\uff08\u5546\u54c1\u540d\uff1a\u8212\u6cf0\u840aR\uff09   2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002  \u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  \u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a   sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  \u5728\u7814ADC\u85e5\u7269\u6301\u7e8c\u91cb\u653e\u50f9\u503c\uff0c\u5275\u65b0\u7814\u767c\u7ba1\u7dda\u968e\u68af\u63a8\u9032 2\u671f\u81e8\u5e8a\u968e\u6bb5 SKB315 (CLDN18.2 ADC)\uff1a   SKB315\u76841b\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u7528\u65bc\u6cbb\u7642\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\/\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u7b49\u3002  SKB315\u6cbb\u7642\u5305\u62ec\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u76841\u671f\u7814\u7a76\u7d50\u679c\u65bc2025\u5e7410\u6708\u57282025\u5e74ESMO\u5927\u6703\u4e0a\u767c\u5e03\u3002  SKB410\/MK-3120 (Nectin-4 ADC)\uff1a   \u5408\u4f5c\u5925\u4f34\u9ed8\u6c99\u6771(MSD)\u5df2\u555f\u52d5\u4e864\u9805SKB410\/MK-3120\u9776\u5411\u8180\u80f1\u764c\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u7684\u5168\u74031\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u3002  SKB571\/MK-2750\uff08\u65b0\u578b\u96d9\u6297ADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB518\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB500\uff08\u65b0\u578bADC\uff09\uff1a2\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 1\u671f\u81e8\u5e8a\u968e\u6bb5 SKB107 (RDC)\u00a0\uff1a1\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 SKB535\/MK-6204\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB535\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB445\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB445\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB105\/CR-003 (ITGB6 ADC)\uff1a2026\u5e741\u6708\uff0c\u8a72\u85e5\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u6279\u51c6\u3002\u4e00\u98051\/2\u671f\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 \u975eADC\u8cc7\u7522\u6230\u7565\u4f48\u5c40\uff0c\u805a\u7126\u806f\u5408\u7642\u6cd5\u8207\u9069\u61c9\u75c7\u62d3\u5c55 \u816b\u7624\u9818\u57df\u5019\u9078\u85e5\u7269   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2026\u5e742\u6708\uff0csac-TMT\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u65b9\u6848\u7684HR+\\\/HER2-\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002 \u4e00\u9805\u91dd\u5c0dsac-TMT\u5c0d\u6bd4ICC\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u7684HR+\\\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a 2025\u5e743\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u548c\u9251\u985e\u5316\u7642\u5931\u6557\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u7528\u65bc\u80ba\u764c\u6cbb\u7642\u7684TROP2 ADC\u85e5\u7269\u3002 2025\u5e7410\u6708\uff0c\u8a72\u516c\u53f8\u5f9e\u570b\u5bb6\u85e5\u76e3\u5c40\u7372\u5f97sac-TMT\u5728\u4e2d\u570b\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904eEGFR-TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684EGFR\u7a81\u8b8a\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u6210\u4eba\u60a3\u8005\u7684\u4e0a\u5e02\u6279\u51c6\u3002\u9019\u662f\u5168\u7403\u9996\u500b\u76f8\u6bd4\u542b\u9251\u96d9\u85e5\u5316\u7642\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f\u7372\u76ca\uff0c\u4e14\u7372\u6279\u7528\u65bc\u50c5\u63a5\u53d7TKI\u6cbb\u7642\u5f8c\u75be\u75c5\u9032\u5c55\u7684\u665a\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08\u4e8c\u7dda\u6cbb\u7642\uff09\u7684ADC\u85e5\u7269\u3002 \u4e00\u9805sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9805sac-TMT\u55ae\u85e5\u6216\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4f5c\u70baEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u65b0\u8f14\u52a9\u6cbb\u7642\u76842\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 EGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a \u4e00\u9805sac-TMT\u806f\u5408KEYTRUDAR\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u5df2\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\u3002\u9019\u662f\u9996\u500b\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684ADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u76843\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 2026\u5e741\u6708\uff0csac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u4e00\u9805sac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u9670\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 \u5176\u4ed6\u9069\u61c9\u75c7\uff1a\u516c\u53f8\u6b63\u7a4d\u6975\u63a2\u7d22sac-TMT\u55ae\u85e5\u53ca\u806f\u5408\u5176\u4ed6\u7642\u6cd5\u5728\u6cbb\u7642\u5176\u4ed6\u5be6\u9ad4\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u5bae\u9838\u764c\u3001\u5375\u5de2\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u53bb\u52e2\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u3001\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u3001\u7532\u72c0\u817a\u764c\u7b49\uff09\u65b9\u9762\u7684\u6f5b\u529b\u3002 \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297(HER2 ADC)\uff08\u4ea6\u7a31A166\uff09\uff08\u5546\u54c1\u540d\uff1a\u8212\u6cf0\u840aR\uff09 2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002 \u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 \u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002 sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002 sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\\\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002 \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002 \u5728\u7814ADC\u85e5\u7269\u6301\u7e8c\u91cb\u653e\u50f9\u503c\uff0c\u5275\u65b0\u7814\u767c\u7ba1\u7dda\u968e\u68af\u63a8\u9032 2\u671f\u81e8\u5e8a\u968e\u6bb5 SKB315 (CLDN18.2 ADC)\uff1a SKB315\u76841b\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u7528\u65bc\u6cbb\u7642\u80c3\u764c\\\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\\\/\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u7b49\u3002 SKB315\u6cbb\u7642\u5305\u62ec\u80c3\u764c\\\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u76841\u671f\u7814\u7a76\u7d50\u679c\u65bc2025\u5e7410\u6708\u57282025\u5e74ESMO\u5927\u6703\u4e0a\u767c\u5e03\u3002 SKB410\\\/MK-3120 (Nectin-4 ADC)\uff1a \u5408\u4f5c\u5925\u4f34\u9ed8\u6c99\u6771(MSD)\u5df2\u555f\u52d5\u4e864\u9805SKB410\\\/MK-3120\u9776\u5411\u8180\u80f1\u764c\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u7684\u5168\u74031\\\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 SKB571\\\/MK-2750\uff08\u65b0\u578b\u96d9\u6297ADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB518\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB500\uff08\u65b0\u578bADC\uff09\uff1a2\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 1\u671f\u81e8\u5e8a\u968e\u6bb5 SKB107 (RDC)\u00a0\uff1a1\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 SKB535\\\/MK-6204\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB535\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 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SKB378\\\/WIN378\uff08TSLP\u55ae\u6297\uff09\uff1a 2025\u5e741\u6708\uff0cSKB378\u7528\u65bc\u6cbb\u7642\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002 \u5408\u4f5c\u5925\u4f34Windward Bio\u5df2\u555f\u52d5\u91dd\u5c0d\u54ee\u5598\u60a3\u8005\u76842\u671fPOLARIS\u5168\u7403\u8a66\u9a57\u3002 SKB575\uff08TSLP\\\/\u672a\u62ab\u9732\u9776\u9ede\u96d9\u6297\uff09\uff1a2026\u5e743\u6708\uff0cSKB575\u7528\u65bc\u6cbb\u7642\u7279\u61c9\u6027\u76ae\u708e\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002 \u5176\u4ed6\u975e\u816b\u7624\u75be\u75c5\u9818\u57df\u5019\u9078\u85e5\u7269 SKB336\uff08FXI\\\/FXIa\u55ae\u6297\uff09\uff1a\u516c\u53f8\u5df2\u5b8c\u6210\u5728\u4e2d\u570b\u958b\u5c55\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 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ADC\uff09\uff08\u4ea6\u7a31SKB264\/MK-2870\uff09\uff08\u5546\u54c1\u540d\uff1a\u4f73\u6cf0\u840aR\uff09 \u4e09\u9670\u6027\u4e73\u817a\u764c\uff1a   \u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6\uff0c\u5728\u4e2d\u570b\u4f7f\u7528sac-TMT\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c112\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002  \u516c\u53f8\u5df2\u555f\u52d5\u4e00\u9805\u91dd\u5c0dsac-TMT\u55ae\u85e5\u5c0d\u6bd4ICC\uff08\u7814\u7a76\u8005\u9078\u64c7\u7684\u5316\u7642\uff09\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u4e09\u9670\u6027\u4e73\u817a\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u3002  HR+\/HER2-\u4e73\u817a\u764c\uff1a   2026\u5e742\u6708\uff0csac-TMT\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u65b9\u6848\u7684HR+\/HER2-\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002  \u4e00\u9805\u91dd\u5c0dsac-TMT\u5c0d\u6bd4ICC\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   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\u4e00\u9805sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9805sac-TMT\u55ae\u85e5\u6216\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4f5c\u70baEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u65b0\u8f14\u52a9\u6cbb\u7642\u76842\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   \u4e00\u9805sac-TMT\u806f\u5408KEYTRUDAR\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u5df2\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\u3002\u9019\u662f\u9996\u500b\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684ADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u76843\u671f\u81e8\u5e8a\u8a66\u9a57\u3002  2026\u5e741\u6708\uff0csac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002  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2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002  \u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  \u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a   sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  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ADC\uff09\uff08\u4ea6\u7a31SKB264\/MK-2870\uff09\uff08\u5546\u54c1\u540d\uff1a\u4f73\u6cf0\u840aR\uff09 \u4e09\u9670\u6027\u4e73\u817a\u764c\uff1a   \u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u4e0a\u5e02\u6279\u51c6\uff0c\u5728\u4e2d\u570b\u4f7f\u7528sac-TMT\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c112\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u4e09\u9670\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002  \u516c\u53f8\u5df2\u555f\u52d5\u4e00\u9805\u91dd\u5c0dsac-TMT\u55ae\u85e5\u5c0d\u6bd4ICC\uff08\u7814\u7a76\u8005\u9078\u64c7\u7684\u5316\u7642\uff09\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u665a\u671f\u4e09\u9670\u6027\u4e73\u817a\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u3002  HR+\/HER2-\u4e73\u817a\u764c\uff1a   2026\u5e742\u6708\uff0csac-TMT\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u65b9\u6848\u7684HR+\/HER2-\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002  \u4e00\u9805\u91dd\u5c0dsac-TMT\u5c0d\u6bd4ICC\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   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\u4e00\u9805sac-TMT\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4e00\u7dda\u6cbb\u7642EGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\uff0c\u4ee5\u53ca\u4e00\u9805sac-TMT\u55ae\u85e5\u6216\u806f\u5408\u5967\u5e0c\u66ff\u5c3c\u4f5c\u70baEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u65b0\u8f14\u52a9\u6cbb\u7642\u76842\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  EGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff1a   \u4e00\u9805sac-TMT\u806f\u5408KEYTRUDAR\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u5c0d\u6bd4\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u5df2\u9054\u5230\u5176\u4e3b\u8981\u7d42\u9ede\u3002\u9019\u662f\u9996\u500b\u5728\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u4e2d\u9054\u5230\u4e3b\u8981\u7d42\u9ede\u7684ADC\u806f\u5408\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u76843\u671f\u81e8\u5e8a\u8a66\u9a57\u3002  2026\u5e741\u6708\uff0csac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002  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2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002  \u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002  \u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a   sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002  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\u4e00\u9805sac-TMT\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u7528\u65bcPD-L1\u9670\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u8a3b\u518a\u6027\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 \u5176\u4ed6\u9069\u61c9\u75c7\uff1a\u516c\u53f8\u6b63\u7a4d\u6975\u63a2\u7d22sac-TMT\u55ae\u85e5\u53ca\u806f\u5408\u5176\u4ed6\u7642\u6cd5\u5728\u6cbb\u7642\u5176\u4ed6\u5be6\u9ad4\u7624\uff08\u5305\u62ec\u80c3\u764c\u3001\u98df\u7ba1\u764c\u3001\u5bae\u9838\u764c\u3001\u5375\u5de2\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u53bb\u52e2\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u3001\u982d\u9838\u90e8\u9c57\u72c0\u7d30\u80de\u764c\u3001\u7532\u72c0\u817a\u764c\u7b49\uff09\u65b9\u9762\u7684\u6f5b\u529b\u3002 \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297(HER2 ADC)\uff08\u4ea6\u7a31A166\uff09\uff08\u5546\u54c1\u540d\uff1a\u8212\u6cf0\u840aR\uff09 2025\u5e7410\u6708\uff0c\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7a2e\u6297HER2\u6cbb\u7642\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u9019\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u7528\u65bc\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u7684\u570b\u7522HER2 ADC\u85e5\u7269\u3002 \u4e00\u9805\u91dd\u5c0d\u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u62d3\u64b2\u7570\u69cb\u9176\u6291\u5236\u5291ADC\u7684HER2\u967d\u6027\u4e73\u817a\u764c\u7684\u958b\u653e\u3001\u591a\u4e2d\u5fc32\u671f\u81e8\u5e8a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 \u95dc\u9375\u81e8\u5e8a\u6578\u64da\u4eae\u76f8\u570b\u969b\u5b78\u8853\u5927\u6703\u53ca\u9802\u7d1a\u671f\u520a sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5927\u6703(2025 ESMO Congress) LBA\uff08\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981\uff09\uff0c\u4e26\u5728\u4e3b\u5e2d\u7814\u8a0e\u6703\u74b0\u7bc0\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002\u8207\u5316\u7642\u76f8\u6bd4\uff0csac-TMT\u5728\u5ba2\u89c0\u7de9\u89e3\u7387\u3001\u7121\u9032\u5c55\u751f\u5b58\u671f\u548c\u7e3d\u751f\u5b58\u671f\u65b9\u9762\u5747\u53d6\u5f97\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584\u3002\u8a72\u7814\u7a76\u7d50\u679c\u540c\u6642\u5728\u7dda\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b(New England Journal of Medicine)\u53ca2026\u5e74\u9996\u671f\u671f\u520a\u3002 sac-TMT\u7528\u65bc\u6cbb\u7642\u4e09\u7ddaEGFR\u7a81\u8b8a\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u7814\u7a76\u7d50\u679c\u5728\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\u5e74\u6703(ASCO Annual Meeting)\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\uff0c\u4e26\u767c\u8868\u65bc\u300a\u82f1\u570b\u91ab\u5b78\u96dc\u8a8c\u300b(British Medical Journal)\u3002\u8a72\u7814\u7a76\u7684\u6700\u7d42\u7e3d\u751f\u5b58\u671f\u5206\u6790\u7d50\u679c\u5c07\u5165\u90782026\u5e74\u6b50\u6d32\u80ba\u764c\u5927\u6703(ELCC)LBA\uff0c\u4e26\u4ee5\u8ff7\u4f60\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002 sac-TMT\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHR+\/HER2-\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002 \u6ce8\u5c04\u7528\u535a\u5ea6\u66f2\u59a5\u73e0\u55ae\u6297\u7528\u65bc\u6cbb\u7642\u4e8c\u7dda\u53ca\u4ee5\u4e0aHER2\u967d\u6027\u4e73\u817a\u764c\u76843\u671f\u7814\u7a76\u7d50\u679c\u5165\u90782025\u5e74ESMO\u5927\u6703LBA\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u5448\u73fe\u3002 \u5728\u7814ADC\u85e5\u7269\u6301\u7e8c\u91cb\u653e\u50f9\u503c\uff0c\u5275\u65b0\u7814\u767c\u7ba1\u7dda\u968e\u68af\u63a8\u9032 2\u671f\u81e8\u5e8a\u968e\u6bb5 SKB315 (CLDN18.2 ADC)\uff1a SKB315\u76841b\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u7528\u65bc\u6cbb\u7642\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\/\u80f0\u817a\u5c0e\u7ba1\u817a\u764c\u7b49\u3002 SKB315\u6cbb\u7642\u5305\u62ec\u80c3\u764c\/\u80c3\u98df\u7ba1\u7d50\u5408\u90e8\u764c\u5728\u5167\u7684\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u76841\u671f\u7814\u7a76\u7d50\u679c\u65bc2025\u5e7410\u6708\u57282025\u5e74ESMO\u5927\u6703\u4e0a\u767c\u5e03\u3002 SKB410\/MK-3120 (Nectin-4 ADC)\uff1a \u5408\u4f5c\u5925\u4f34\u9ed8\u6c99\u6771(MSD)\u5df2\u555f\u52d5\u4e864\u9805SKB410\/MK-3120\u9776\u5411\u8180\u80f1\u764c\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u7684\u5168\u74031\/2\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 SKB571\/MK-2750\uff08\u65b0\u578b\u96d9\u6297ADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB518\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1a2\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB500\uff08\u65b0\u578bADC\uff09\uff1a2\u671f\u7814\u7a76\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 1\u671f\u81e8\u5e8a\u968e\u6bb5 SKB107 (RDC)\u00a0\uff1a1\u671f\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\u3002 SKB535\/MK-6204\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB535\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB445\uff08\u6f5b\u5728\u540c\u985e\u9996\u5275\u9776\u9ede\u65b0\u578bADC\uff09\uff1aSKB445\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 SKB105\/CR-003 (ITGB6 ADC)\uff1a2026\u5e741\u6708\uff0c\u8a72\u85e5\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u6279\u51c6\u3002\u4e00\u98051\/2\u671f\u8a66\u9a57\u6b63\u5728\u4e2d\u570b\u9032\u884c\u3002 \u975eADC\u8cc7\u7522\u6230\u7565\u4f48\u5c40\uff0c\u805a\u7126\u806f\u5408\u7642\u6cd5\u8207\u9069\u61c9\u75c7\u62d3\u5c55 \u816b\u7624\u9818\u57df\u5019\u9078\u85e5\u7269 \u5854\u6208\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08PD-L1\u55ae\u6297\uff0c\u4ea6\u7a31A167\uff09\uff08\u5546\u54c1\u540d\uff1a\u79d1\u6cf0\u840aR\uff09\uff1a2025\u5e741\u6708\uff0c\u8a72\u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\uff0c\u5c07\u5854\u6208\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u3002\u5854\u6208\u5229\u55ae\u6297\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u7684PD-L1\u55ae\u6297\u3002 2025\u5e745\u6708\uff0c\u5854\u6208\u5229\u55ae\u6297\u806f\u5408\u9806\u9251\u548c\u5409\u897f\u4ed6\u6ff1\u7528\u65bc\u9f3b\u54bd\u764c\u4e00\u7dda\u6cbb\u7642\u76843\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5728ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u3002 \u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\uff08EGFR\u55ae\u6297\uff0c\u4ea6\u7a31A140\uff09\uff08\u5546\u54c1\u540d\uff1a\u9054\u6cf0\u840aR\uff09\uff1a 2025\u5e742\u6708\uff0c\u8a72\u516c\u53f8\u7372\u5f97\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\uff0c\u5c07\u897f\u59a5\u6614\u55ae\u6297N01\u6ce8\u5c04\u6db2\u806f\u5408FOLFOX\u6216FOLFIRI\u65b9\u6848\u7528\u65bcRAS\u57fa\u56e0\u91ce\u751f\u578b\u8f49\u79fb\u6027\u7d50\u76f4\u8178\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u3002 \u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u81a0\u56ca\uff08RET\u6291\u5236\u5291\uff0c\u4ea6\u7a31A400\/EP0031\uff09\uff08\u5546\u54c1\u540d\uff1a\u5be7\u6cf0\u840aR\uff09\uff1a \u7528\u65bc\u4e00\u7dda\u53ca\u4ee5\u4e0a\u6cbb\u7642RET\u878d\u5408\u967d\u6027\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\u53d7\u7406\u3002 \u8a72\u516c\u53f8\u9084\u5728\u4e2d\u570b\u958b\u5c55\u91dd\u5c0dRET\u967d\u6027\u7532\u72c0\u817a\u9ad3\u6a23\u764c\u53ca\u5be6\u9ad4\u7624\u76841b\/2\u671f\u81e8\u5e8a\u7814\u7a76\u3002 Ellipses Pharma\u6b63\u5728\u4e2d\u570b\u4ee5\u5916\u7684\u5730\u5340\u63a8\u9032\u51762\u671f\u81e8\u5e8a\u7814\u7a76\u3002 2025\u5e745\u6708\uff0c\u5bcc\u99ac\u9178\u4f96\u535a\u66ff\u5c3c\u81a0\u56ca\u6cbb\u7642\u665a\u671fRET\u7a81\u8b8a\u578b\u7532\u72c0\u817a\u9ad3\u6a23\u764c\u76841\u671f\u7814\u7a76\u7d50\u679c\u5728ASCO\u5e74\u6703\u4e0a\u516c\u4f48\u3002 SKB118\/CR-001\uff08PD-1\/VEGF\u96d9\u6297\uff09\uff1a 2026\u5e741\u6708\uff0cCrescent Biopharma\u5ba3\u4f48\u5176\u7528\u65bc\u6cbb\u7642\u665a\u671f\u5be6\u9ad4\u7624\u7684SKB118\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u5df2\u7372FDA\u6279\u51c6\uff0c\u555f\u52d5\u5168\u7403ASCEND 1\/2\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u9996\u4f8b\u60a3\u8005\u5df2\u65bc2026\u5e742\u6708\u7d66\u85e5\u3002 \u516c\u53f8\u8a08\u5283\u65bc2026\u5e74\u4e0a\u534a\u5e74\u5728\u4e2d\u570b\u555f\u52d5SKB118\u76841\/2\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u9818\u57df\u5019\u9078\u85e5\u7269 SKB378\/WIN378\uff08TSLP\u55ae\u6297\uff09\uff1a 2025\u5e741\u6708\uff0cSKB378\u7528\u65bc\u6cbb\u7642\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002 \u5408\u4f5c\u5925\u4f34Windward Bio\u5df2\u555f\u52d5\u91dd\u5c0d\u54ee\u5598\u60a3\u8005\u76842\u671fPOLARIS\u5168\u7403\u8a66\u9a57\u3002 SKB575\uff08TSLP\/\u672a\u62ab\u9732\u9776\u9ede\u96d9\u6297\uff09\uff1a2026\u5e743\u6708\uff0cSKB575\u7528\u65bc\u6cbb\u7642\u7279\u61c9\u6027\u76ae\u708e\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\u7372\u570b\u5bb6\u85e5\u76e3\u5c40\u6279\u51c6\u3002 \u5176\u4ed6\u975e\u816b\u7624\u75be\u75c5\u9818\u57df\u5019\u9078\u85e5\u7269 SKB336\uff08FXI\/FXIa\u55ae\u6297\uff09\uff1a\u516c\u53f8\u5df2\u5b8c\u6210\u5728\u4e2d\u570b\u958b\u5c55\u76841\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 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