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IU\/mL\u4e4b\u9593\uff0c\u8868\u660eBRII-179\u53ef\u80fd\u5728\u66f4\u5ee3\u6cdb\u7684HBsAg\u57fa\u7dda\u6c34\u5e73\u7bc4\u570d\u5167\u8a98\u5c0e\u6297-HBs\u61c9\u7b54\u3002<\/p>\n<p class=\"prnml40\">ENSURE\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u6578\u64da\u9810\u8a08\u5c07\u65bc2026\u5e74\u4e0a\u534a\u5e74\u516c\u4f48\uff0c\u4e26\u5c07\u5728\u5f8c\u7e8c\u7684\u79d1\u5b78\u6703\u8b70\u4e0a\u532f\u5831\u3002<\/p>\n<ul type=\"disc\">\n<li>\u70ba\u9032\u4e00\u6b65\u660e\u78baBRII-179\u5728HBV\u6cbb\u7642\u4e2d\u7684\u4f5c\u7528\uff0c\u4e26\u78ba\u5b9a\u6f5b\u5728\u8a3b\u518a\u6027\u958b\u767c\u6240\u9700\u7684\u6700\u4f73\u806f\u5408\u7528\u85e5\u65b9\u6848\uff0c\u516c\u53f8\u6b63\u5728\u5169\u9805\u984d\u5916\u9032\u884c\u4e2d\u7684IIb\u671f\u7814\u7a76\u4e2d\u8a55\u4f30BRII-179\u3002<\/li>\n<\/ul>\n<p class=\"prnml40\">&#8211; ENRICH\u7814\u7a76\uff1a\u8a55\u4f30BRII-179\u5728\u6fc0\u6d3bHBV\u7279\u7570\u6027\u514d\u75ab\u548c\/\u6216\u8b58\u5225\u514d\u75ab\u61c9\u7b54\u53cd\u61c9\u826f\u597d\u3001\u66f4\u53ef\u80fd\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u7652\u7684\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<p class=\"prnml40\">&#8211; ENHANCE\u7814\u7a76\uff1a\u8a55\u4f30BRII-179\u806f\u5408elebsiran\u8207PEG-IFN\u03b1\u7684\u4e09\u806f\u6cbb\u7642\u65b9\u6848\uff0c\u65e8\u5728\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u7652\u7387\u3002\u57fa\u65bcENSURE\u968a\u52174\u7814\u7a76\u7684\u767c\u73fe\uff0c\u7814\u7a76\u65b9\u6848\u7d93\u4fee\u8a02\u5f8c\u5c07\u8a55\u4f30\u7c21\u5316\u7248\u4e09\u806f\u6cbb\u7642\u65b9\u6848\uff0c\u8a72\u65b9\u6848\u65e8\u5728\u5c07PEG-IFN\u03b1\u6cbb\u7642\u9031\u671f\u7e2e\u77ed\u81f324\u5468\u3002<\/p>\n<p>\u6240\u6709\u7814\u7a76\u76ee\u524d\u5747\u5df2\u5b8c\u6210\u53d7\u8a66\u8005\u5165\u7d44\uff0cENRICH\u548cENHANCE\u5169\u9805\u7814\u7a76\u7684\u6578\u64da\u9810\u8a08\u5c07\u65bc2026\u5e74\u4e0b\u534a\u5e74\u516c\u4f48\u3002<\/p>\n<ul type=\"disc\">\n<li>\u8207\u6b64\u540c\u6642\uff0c\u516c\u53f8\u5df2\u8207\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u5c55\u958b\u6e9d\u901a\uff0c\u5171\u540c\u63a2\u8a0e\u6f5b\u5728\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\u8a2d\u8a08\u53ca\u4e3b\u8981\u7d42\u9ede\u6307\u6a19\u3002\u6b63\u5728\u9032\u884c\u7684ENRICH\u548cENHANCE\u7814\u7a76\u7d50\u679c\u5c07\u70ba\u672a\u4f86\u7684\u8a3b\u518a\u6027\u81e8\u5e8a\u958b\u767c\u6c7a\u7b56\u63d0\u4f9b\u4f9d\u64da\u3002<\/li>\n<\/ul>\n<p><b>\u5176\u4ed6\u81e8\u5e8a\u9805\u76ee<\/b>\u00a0<\/p>\n<ul type=\"disc\">\n<li>2025\u5e747\u6708\uff0c\u9a30\u76db\u535a\u85e5\u5ba3\u4f48\u8207\u5065\u5eb7\u5143\u96c6\u5718\u9054\u6210\u6230\u7565\u6388\u6b0a\u5354\u8b70\uff0c\u6388\u6b0a\u5f8c\u8005\u5728\u5927\u4e2d\u83ef\u5340\u958b\u5c55soralimixin\u7684\u7814\u767c\u53ca\u5546\u696d\u5316\u5de5\u4f5c\u3002\u6b64\u6b21\u5408\u4f5c\u5c07\u4f9d\u6258\u5065\u5eb7\u5143\u96c6\u5718\u5728\u6297\u611f\u67d3\u6cbb\u7642\u9818\u57df\u7684\u6210\u719f\u80fd\u529b\uff0c\u52a0\u901fsoralimixin\u7684\u7814\u767c\u9032\u7a0b\u4e26\u6700\u5927\u5316\u5176\u5546\u696d\u6f5b\u529b\u3002\u516c\u53f8\u4fdd\u7559\u5927\u4e2d\u83ef\u5340\u4ee5\u5916\u7684\u6b0a\u76ca\uff0c\u4e26\u5c07\u6301\u7e8c\u5c0b\u6c42\u975e\u7a00\u91cb\u6027\u878d\u8cc7\u53ca\u62d3\u5c55\u5408\u4f5c\u7684\u6a5f\u6703\u3002<\/li>\n<li>\u9a30\u76db\u535a\u85e5\u6b63\u7a4d\u6975\u5c0b\u6c42\u5916\u90e8\u5408\u4f5c\uff0c\u4ee5\u63a8\u9032\u5176\u7528\u65bc\u6cbb\u7642\u548c\u9810\u9632\u4eba\u985e\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u611f\u67d3\uff08HIV\uff09\u7684\u9577\u6548\u5019\u9078\u85e5\u7269\u7684\u958b\u767c\u8207\u5546\u696d\u5316\u9032\u7a0b\u3002<\/li>\n<\/ul>\n<p><b><u>\u65e9\u671f\u7814\u767c\u9805\u76ee\u9032\u5c55<\/u><\/b><\/p>\n<ul type=\"disc\">\n<li>\u622a\u81f32025\u5e74\u5e95\uff0c\u9a30\u76db\u535a\u85e5\u5728\u5317\u4eac\u904b\u71df\u4e86\u8f49\u5316\u7814\u7a76\u5be6\u9a57\u5ba4\uff0c\u5728\u4e0a\u6d77\u8a2d\u7acb\u4e86\u914d\u5099\u5c16\u7aef\u8a2d\u5099\u7684\u5168\u6d41\u7a0b\u6574\u5408\u65e9\u7814\u5be6\u9a57\u5ba4\uff0c\u4e26\u7d44\u5efa\u4e86\u884c\u696d\u7d93\u9a57\u8c50\u5bcc\u7684\u65e9\u7814\u5718\u968a\u3002\u4f9d\u6258\u8986\u84cb\u4e2d\u7f8e\u5169\u570b\u7684\u5168\u7403\u7814\u767c\u7db2\u7d61\uff0c\u9a30\u76db\u535a\u85e5\u65e8\u5728\u878d\u5408\u4e2d\u570b\u672c\u571f\u7814\u767c\u7684\u5275\u65b0\u80fd\u529b\u8207\u57f7\u884c\u6548\u7387\uff0c\u4ee5\u53ca\u5168\u7403\u85e5\u7269\u767c\u73fe\u8207\u958b\u767c\u9818\u57df\u7684\u6df1\u539a\u5c08\u696d\u7a4d\u6fb1\u3002\u9019\u7a2e\u904b\u71df\u6a21\u5f0f\u80fd\u5920\u5feb\u901f\u5c07\u79d1\u5b78\u767c\u73fe\u8f49\u5316\u70ba\u53ef\u9a57\u8b49\u7684\u6cbb\u7642\u5047\u8a2d\uff0c\u9ad8\u6548\u7be9\u9078\u9776\u9ede\uff0c\u4e26\u63a8\u52d5\u65e9\u671f\u9805\u76ee\u7a69\u6b65\u8de8\u8d8a\u95dc\u9375\u958b\u767c\u91cc\u7a0b\u7891\u3002<\/li>\n<li>12\u6708\uff0c\u9a30\u76db\u535a\u85e5\u5ba3\u4f48\u8207OpenBench\u5efa\u7acb\u5408\u4f5c\u95dc\u4fc2\uff0c\u501f\u52a9\u5176\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u5e73\u53f0\u52a0\u901f\u516c\u53f8\u7684\u85e5\u7269\u767c\u73fe\u9032\u7a0b\u3002<\/li>\n<li>\u96a8\u8457\u6211\u5011\u6301\u7e8c\u63a8\u9032\u76f8\u95dc\u9805\u76ee\u9081\u5411\u81e8\u5e8a\u968e\u6bb5\uff0c\u9810\u8a08\u5c07\u57282026\u5e74\u5168\u5e74\u9678\u7e8c\u516c\u4f48\u9a30\u76db\u535a\u85e5\u65e9\u671f\u7814\u767c\u9805\u76ee\u7684\u66f4\u591a\u9032\u5c55\u3002<\/li>\n<\/ul>\n<p><b><u>\u5176\u4ed6\u4f01\u696d\u66f4\u65b0<\/u><\/b><\/p>\n<p>\u70ba\u9032\u4e00\u6b65\u5f37\u5316\u7ba1\u7406\u5c64\u6fc0\u52f5\u8207\u516c\u53f8\u9577\u671f\u80a1\u6771\u5229\u76ca\u4e4b\u9593\u7684\u4e00\u81f4\u6027\uff0c\u8463\u4e8b\u6703\u6279\u51c6\u4e86\u5c0d2025\u5e74\u548c2026\u5e74\u9ad8\u7d1a\u7ba1\u7406\u5c64\u5e74\u5ea6\u734e\u91d1\u5b89\u6392\u7684\u8abf\u6574\u65b9\u6848\u3002\u6839\u64da\u8a72\u65b9\u6848\uff0c\u5728\u4e0a\u8ff0\u5404\u5e74\uff0c\u516c\u53f8\u56e0\u9ad8\u7ba1\u5e74\u5ea6\u734e\u91d1\u7522\u751f\u7684\u85aa\u916c\u7e3d\u652f\u51fa\u5c07\u5927\u5e45\u6e1b\u5c11\uff0c\u964d\u81f3\u539f\u6c34\u5e73\u7684\u7d04\u56db\u5206\u4e4b\u4e00\u3002\u6b64\u8209\u9ad4\u73fe\u4e86\u516c\u53f8\u5728\u8ca1\u52d9\u7ba1\u7406\u4e0a\u7684\u5be9\u614e\u6027\uff0c\u4e26\u4f7f\u7ba1\u7406\u5c64\u85aa\u916c\u66f4\u7dca\u5bc6\u5730\u8207\u696d\u52d9\u8868\u73fe\u3001\u8cc7\u672c\u5e02\u5834\u7d50\u679c\u4ee5\u53ca\u9577\u671f\u80a1\u6771\u50f9\u503c\u5275\u9020\u76f8\u5339\u914d\u3002<\/p>\n<p><b><u>\u5c55\u671b<\/u><\/b><\/p>\n<p>\u5c55\u671b\u672a\u4f86\uff0c\u516c\u53f8\u5c07\u7e7c\u7e8c\u5c08\u6ce8\u65bc\u7a69\u5065\u57f7\u884c\u8207\u6301\u7e8c\u5275\u65b0\uff0c\u63a8\u52d5\u5176\u81e8\u5e8a\u5f8c\u671f\u7684HBV\u9805\u76ee\u53ca\u65e9\u7814\u9805\u76ee\u3002\u9810\u8a08\u65bc2026\u5e74\u516c\u4f48\u7684ENRICH\u548cENHANCE\u5169\u9805 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type=\"disc\">\n<li>\u622a\u81f32025\u5e7412\u670831\u65e5\uff0c\u6211\u5011\u7684\u9280\u884c\u5b58\u6b3e\u3001\u73fe\u91d1\u53ca\u73fe\u91d1\u7b49\u50f9\u7269\u70ba\u4eba\u6c11\u5e6319.41\u5104\u5143\uff0c\u8207\u622a\u81f32024\u5e7412\u670831\u65e5\u7684\u4eba\u6c11\u5e6324.134\u5104\u5143\u76f8\u6bd4\uff0c\u6e1b\u5c11\u4e86\u4eba\u6c11\u5e63<span 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2025\u5e74\uff0cBRII-179\u5728\u968a\u52174\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5c55\u73fe\u51fa\u7a4d\u6975\u7684\u7d50\u679c\u3002\u95dc\u9375\u6578\u64da\u5df2\u5728\u4e9e\u592a\u809d\u75c5\u5b78\u6703\uff08APASL\uff09\u5e74\u6703\u3001\u6b50\u6d32\u809d\u75c5\u5b78\u6703\uff08EASL\uff09\u5e74\u6703\u53ca\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\uff08AASLD\uff09\u809d\u75c5\u6703\u8b70\u00ae\u7b49\u570b\u969b\u809d\u75c5\u9818\u57df\u91cd\u8981\u5b78\u8853\u6703\u8b70\u4e0a\u767c\u4f48\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u4e86BRII-179\u5728\u63d0\u5347\u6162\u6027\u4e59\u578b\u809d\u708e\u529f\u80fd\u6027\u6cbb\u7652\u7387\u65b9\u9762\u7684\u6f5b\u529b\u3002 \u95dc\u9375\u767c\u73fe\u5305\u62ec\uff1a - BRII-179\u8a98\u5c0e\u7684\u6297-HBs\u61c9\u7b54\u8005\uff08520 IU\/mL\uff09\u7684HBsAg\u57fa\u7dda\u4e2d\u4f4d\u6578\u6578\u503c\u9ad8\u65bc\u7121\u61c9\u7b54\u8005\uff08185 IU\/mL\uff09\u3002 - \u5728\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c\u7b2c24\u5468\uff0c\u572842.1%\uff088\/19\uff09\u7684BRII-179\u8a98\u5c0e\u7684\u6297-HBs\u61c9\u7b54\u8005\u4e2d\u89c0\u5bdf\u5230HBsAg\u6e05\u9664\uff0c\u800c\u7121\u61c9\u7b54\u8005\u4e2d\u8a72\u6bd4\u4f8b\u70ba8.3%\uff081\/12\uff09\u3002 - \u5118\u7ba1\u5728ENSURE\u7814\u7a76\u4e2d\uff0c\u6240\u6709\u5be6\u73fe\u6301\u7e8cHBsAg\u6e05\u9664\u7684\u53c3\u8207\u8005HBsAg\u57fa\u7dda\u6c34\u5e73\u5747\u4f4e\u65bc1,500 IU\/mL\uff0c \u5176\u4e2d50%\uff084\/8\u4f8b\uff09\u6297-HBs\u61c9\u7b54\u8005\u5728\u5148\u524d\u7814\u7a76\u5165\u7d44\u6642\u7684HBsAg\u57fa\u7dda\u6c34\u5e73\u4ecb\u65bc1,514\u81f33,086 IU\/mL\u4e4b\u9593\uff0c\u8868\u660eBRII-179\u53ef\u80fd\u5728\u66f4\u5ee3\u6cdb\u7684HBsAg\u57fa\u7dda\u6c34\u5e73\u7bc4\u570d\u5167\u8a98\u5c0e\u6297-HBs\u61c9\u7b54\u3002 ENSURE\u7814\u7a76\u7684\u9577\u671f\u96a8\u8a2a\u6578\u64da\u9810\u8a08\u5c07\u65bc2026\u5e74\u4e0a\u534a\u5e74\u516c\u4f48\uff0c\u4e26\u5c07\u5728\u5f8c\u7e8c\u7684\u79d1\u5b78\u6703\u8b70\u4e0a\u532f\u5831\u3002   \u70ba\u9032\u4e00\u6b65\u660e\u78baBRII-179\u5728HBV\u6cbb\u7642\u4e2d\u7684\u4f5c\u7528\uff0c\u4e26\u78ba\u5b9a\u6f5b\u5728\u8a3b\u518a\u6027\u958b\u767c\u6240\u9700\u7684\u6700\u4f73\u806f\u5408\u7528\u85e5\u65b9\u6848\uff0c\u516c\u53f8\u6b63\u5728\u5169\u9805\u984d\u5916\u9032\u884c\u4e2d\u7684IIb\u671f\u7814\u7a76\u4e2d\u8a55\u4f30BRII-179\u3002  - ENRICH\u7814\u7a76\uff1a\u8a55\u4f30BRII-179\u5728\u6fc0\u6d3bHBV\u7279\u7570\u6027\u514d\u75ab\u548c\/\u6216\u8b58\u5225\u514d\u75ab\u61c9\u7b54\u53cd\u61c9\u826f\u597d\u3001\u66f4\u53ef\u80fd\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u7652\u7684\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002 - 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