{"id":418519,"date":"2026-03-17T18:00:00","date_gmt":"2026-03-17T10:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=418519"},"modified":"2026-03-17T18:00:00","modified_gmt":"2026-03-17T10:00:00","slug":"%e5%8f%a3%e6%9c%8d%e5%b0%8f%e5%88%86%e5%ad%90%e8%83%b0%e6%be%b1%e7%b4%a0%e5%8f%97%e9%ab%94%e6%bf%80%e5%8b%95%e5%8a%91asc39%e5%9c%a8%e8%87%a8%e5%ba%8a%e5%89%8d%e6%a8%a1%e5%9e%8b%e4%b8%ad%e9%a1%af","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=418519","title":{"rendered":"\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291ASC39\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u985e\u4f3celoralintide\u7684\u80f0\u6fb1\u7d20\u9078\u64c7\u6027\u8207\u7642\u6548"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

–<\/i>\u5728\u8207<\/i>eloralintide<\/i>\u7684\u982d\u5c0d\u982d\u74b0\u78f7\u9178\u817a\u7518\uff08<\/i>cAMP<\/i>\uff09\u6fc0\u6d3b\u5be6\u9a57\u4e2d\uff0c\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291<\/i>ASC39<\/i>\u986f\u793a\u51fa\u8207<\/i>eloralintide<\/i>\u76f8\u4f3c\u7684\u9078\u64c7\u6027\u8207\u6d3b\u6027\u3002<\/i>ASC39<\/i>\u8207<\/i>eloralintide<\/i>\u5c0d\u4eba\u80f0\u6fb1\u7d20<\/i>1<\/i>\u578b\u53d7\u9ad4\uff08<\/i>hAMY1R<\/i>\uff09\u7684<\/i>EC<\/i>50<\/sub><\/i>\u5206\u5225\u70ba<\/i>21.4 pM<\/i>\u548c<\/i>21.2 pM<\/i>\u3002<\/i>ASC39<\/i>\u8207<\/i>eloralintide<\/i>\u5c0d\u4eba\u964d\u9223\u7d20\u53d7\u9ad4\uff08<\/i>hCTR<\/i>\uff09\u7684<\/i>EC<\/i>50<\/sub><\/i>\u5206\u5225\u70ba<\/i>846.1 pM<\/i>\u548c<\/i>1,350.8 pM<\/i>\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0c\u76f8\u8f03\u65bc<\/i>hCTR<\/i>\uff0c<\/i>ASC39<\/i>\u8207<\/i>eloralintide<\/i>\u90fd\u5c0d<\/i>hAMY1R<\/i>\u66f4\u5177\u6709\u9078\u64c7\u6027\uff0c\u4e14\u9078\u64c7\u6027\u76f8\u7576\u3002<\/i><\/p>\n

–<\/i>\u5728\u8207<\/i>eloralintide<\/i>\u7684\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08<\/i>DIO<\/i>\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff0c<\/i>ASC39<\/i>\u7684\u53e3\u670d\u7d66\u85e5\u7642\u6548\u8207<\/i>eloralintide<\/i>\u7684\u76f8\u7576\uff0c\u986f\u793a\u51fa\u986f\u8457\u7684\u3001\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u9ad4\u91cd\u4e0b\u964d\uff0c<\/i>ASC39<\/i>\u70ba<\/i>6.6%<\/i>\uff0c<\/i>eloralintide<\/i>\u70ba<\/i>5.6%<\/i>\u3002<\/i><\/p>\n

–<\/i>\u9810\u8a08\u5c07\u65bc<\/i>2026<\/i>\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/i>FDA<\/i>\uff09\u905e\u4ea4<\/i>ASC39<\/i>\u53e3\u670d\u7247\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08<\/i>IND<\/i>\uff09\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2026\u5e743\u670817\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\u5df2\u9078\u5b9a\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291ASC39\u4f5c\u70ba\u81e8\u5e8a\u958b\u767c\u5019\u9078\u85e5\u7269\u3002\u6b4c\u79ae\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e09\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC39\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002<\/p>\n

\n<\/p><\/div>\n

ASC39\u5177\u6709\u7368\u7279\u7684\u5316\u5b78\u9aa8\u67b6\uff0c\u8a72\u5316\u5b78\u9aa8\u67b6\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u6280\u8853\u81ea\u4e3b\u767c\u73fe\u7684\u3002\u5728ASC39\u8207eloralintide\u7684\u982d\u5c0d\u982d\u74b0\u78f7\u9178\u817a\u7518\uff08cAMP\uff09\u6fc0\u6d3b\u5be6\u9a57\u4e2d\uff0cASC39\u8207eloralintide\uff08\u80f0\u6fb1\u7d20\u591a\u80bd\u985e\u4f3c\u7269\uff09\u5c0d\u4eba\u80f0\u6fb1\u7d201\u578b\u53d7\u9ad4\uff08hAMY1R\uff09\u7684EC50<\/sub>\uff08\u534a\u6578\u6700\u5927\u6709\u6548\u6fc3\u5ea6\uff09\u5206\u5225\u70ba21.4 pM\u548c21.2 pM\u3002ASC39\u8207eloralintide\u5c0d\u4eba\u964d\u9223\u7d20\u53d7\u9ad4\uff08hCTR\uff09\u7684EC50<\/sub>\u5206\u5225\u70ba846.1 pM\u548c1,350.8 pM\u3002\u9019\u4e9b\u6578\u64da\u8868\u660e\uff0c\u76f8\u8f03\u65bchCTR\uff0cASC39\u5c0dhAMY1R\u5177\u6709\u9ad8\u5ea6\u9078\u64c7\u6027\uff0c\u4e14ASC39\u5c0dhAMY1R\u7684\u9078\u64c7\u6027\u8207eloralintide\u76f8\u7576\u3002ASC39\u8207eloralintide\u5c0dhAMY1R\u7684\u9078\u64c7\u6027\u6bd4\u5c0dhCTR\u7684\u5206\u5225\u9ad840\u500d\u548c64\u500d\u3002<\/p>\n

\u5728\u4e00\u9805\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff0c\u8207\u63a5\u53d7\u5b89\u6170\u5291\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20\u76f8\u6bd4\uff0cASC39\u6bcf\u65e5\u53e3\u670d\u7d66\u85e5\u986f\u793a\u51fa\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u7684\u9ad4\u91cd\u4e0b\u964d\uff0c\u8207eloralintide\u76f8\u7576\uff08\u898b\u88681\uff09\u3002\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e55 mg\/kg\u7684ASC39\uff0c\u9023\u7e8c\u7d66\u85e56\u5929\uff0c\u7522\u751f\u4e86\u986f\u8457\u7684\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u9ad4\u91cd\u4e0b\u964d6.6%\u3002\u6bcf\u4e09\u5929\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c043 nmol\/kg\u7684eloralintide\uff0c\u9023\u7e8c6\u5929\uff0c\u7522\u751f\u4e86\u986f\u8457\u7684\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u9ad4\u91cd\u4e0b\u964d5.6%\uff0c\u8207\u6587\u737b\u6578\u64da\u4e00\u81f4[1]<\/sup>\u3002<\/p>\n

\u88681. ASC39\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u9023\u7e8c6\u5929\u7522\u751f\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u7684\u9ad4\u91cd\u4e0b\u964d\uff0c\u5176\u7642\u6548\u8207eloralintide\u7684\u76f8\u7576\u3002<\/p>\n

\n\n\n\n\n\n\n
\n

\u7d44\u5225<\/span><\/p>\n<\/td>\n

\n

\u7d66\u85e5<\/span><\/p>\n<\/td>\n

\n

\u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u63a5\u53d7\u5b89\u6170\u5291\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291\uff0c<\/span><\/p>\n

\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

0.6\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u63a5\u53d7eloralintide\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20<\/span><\/p>\n<\/td>\n

\n

3 nmol\/kg\uff0c<\/span><\/p>\n

\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u4e09\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

-5.0%<\/span><\/p>\n

(p<\/i><0.0001\u5c0d\u6bd4\u63a5\u53d7\u5b89\u6170\u5291
\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u63a5\u53d7ASC39\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20<\/span><\/p>\n<\/td>\n

\n

5 mg\/kg\uff0c<\/span><\/p>\n

\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/p>\n<\/td>\n

\n

-6.0%<\/span><\/p>\n

(p<\/i><0.0001\u5c0d\u6bd4\u63a5\u53d7\u5b89\u6170\u5291
\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u8a3b\u91cb\uff1a
<\/i>a. \u7b2c1\u5929\u9ad4\u91cd\u88ab\u8a2d\u70ba\u57fa\u7dda\u3002
b. \u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\u3002<\/p>\n

ASC39\u5728\u5927\u9f20\u8207\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u5c55\u793a\u4e86\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u652f\u6301\u5176\u5728\u4eba\u9ad4\u4e2d\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u3002<\/p>\n

\u300c\u6b4c\u79ae\u81f4\u529b\u65bc\u70ba\u80a5\u80d6\u60a3\u8005\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u70ba\u6b64\uff0c\u6211\u5011\u5f88\u9ad8\u8208\u5c07\u5728\u4eca\u5e74\u665a\u4e9b\u6642\u5019\u63a8\u9032\u9996\u500b\u985e\u4f3celoralintide\u7684\u9078\u64c7\u6027\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u53e3\u670d\u5c0f\u5206\u5b50\u9032\u5165\u81e8\u5e8a\u3002\u6211\u5011\u76f8\u4fe1\uff0cASC39\u53ef\u80fd\u63d0\u4f9b\u8207\u79ae\u4f86\uff08Eli Lilly\uff09\u7684eloralintide\u76f8\u4f3c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff0c\u540c\u6642\u5177\u5099\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u5c0f\u5206\u5b50\u5c0d\u60a3\u8005\u7684\u4fbf\u5229\u6027\uff0c\u4ee5\u53ca\u5546\u696d\u898f\u6a21\u5316\u6f5b\u529b<\/span>\u3002\u300d<\/p>\n

ASC39\u662f\u4e00\u7a2e\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u6b63\u5728\u65e2\u4f5c\u70ba\u55ae\u85e5\u958b\u767c\uff0c\u4e5f\u4f5c\u70ba\u8207ASC30\u806f\u7528\uff08ASC30\u70ba\u6b4c\u79ae\u53e3\u670d\u5c0f\u5206\u5b50\u3001\u5df2\u5177\u5099III\u671f\u689d\u4ef6\u7684GLP-1\u5019\u9078\u85e5\u7269\uff09\u958b\u767c\uff0c\u4ee5\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7<\/span>\u5728\u5167\u7684\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u8a72\u65b0\u578b\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u9805\u76ee\u5f37\u5316\u4e86\u6b4c\u79ae\u73fe\u6709\u7684\u80f0\u6fb1\u7d20\u591a\u80bd\u5019\u9078\u85e5\u7269\u7d44\u5408\uff0c\u5305\u62ecASC36\uff08\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u80f0\u6fb1\u7d20\u591a\u80bd\u55ae\u85e5\u7642\u6cd5\uff09\uff0c\u4ee5\u53caASC36\u8207\u6bcf\u6708\u4e00\u6b21ASC35\uff08GLP-1\/GIP\u76ae\u4e0b\u6ce8\u5c04\u591a\u80bd\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u7d44\u5408\u3002<\/p>\n

[1] Briere DA, Qu H, Lansu K, et al. Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. Mol Metab. 2025;102:102271. doi:10.1016\/j.molmet.2025.102271<\/p>\n

\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/b><\/p>\n

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ICR Healthcare
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Peter.vozzo@icrhealthcare.com<\/a>\u00a0<\/p>\n

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Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. Mol Metab. 2025;102:102271. doi:10.1016\/j.molmet.2025.102271 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3eGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC39\uff0c\u4e00\u6b3e\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com\u00a0 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.com ir@ascletis.com\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=418519\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291ASC39\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u985e\u4f3celoralintide\u7684\u80f0\u6fb1\u7d20\u9078\u64c7\u6027\u8207\u7642\u6548 - 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ASC39\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u9023\u7e8c6\u5929\u7522\u751f\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u7684\u9ad4\u91cd\u4e0b\u964d\uff0c\u5176\u7642\u6548\u8207eloralintide\u7684\u76f8\u7576\u3002 \u7d44\u5225 \u7d66\u85e5 \u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u63a5\u53d7\u5b89\u6170\u5291\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20 \u5b89\u6170\u5291\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21 0.6\u00a0% \u63a5\u53d7eloralintide\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20 3 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u4e09\u65e5\u4e00\u6b21 -5.0%(p<0.0001\u5c0d\u6bd4\u63a5\u53d7\u5b89\u6170\u5291\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20) \u63a5\u53d7ASC39\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20 5 mg\/kg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21 -6.0%(p<0.0001\u5c0d\u6bd4\u63a5\u53d7\u5b89\u6170\u5291\u7d66\u85e5\u7684\u80a5\u80d6\u5927\u9f20) \u8a3b\u91cb\uff1aa. \u7b2c1\u5929\u9ad4\u91cd\u88ab\u8a2d\u70ba\u57fa\u7dda\u3002b. \u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\u3002 ASC39\u5728\u5927\u9f20\u8207\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u5c55\u793a\u4e86\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u652f\u6301\u5176\u5728\u4eba\u9ad4\u4e2d\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u3002 \u300c\u6b4c\u79ae\u81f4\u529b\u65bc\u70ba\u80a5\u80d6\u60a3\u8005\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u70ba\u6b64\uff0c\u6211\u5011\u5f88\u9ad8\u8208\u5c07\u5728\u4eca\u5e74\u665a\u4e9b\u6642\u5019\u63a8\u9032\u9996\u500b\u985e\u4f3celoralintide\u7684\u9078\u64c7\u6027\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u53e3\u670d\u5c0f\u5206\u5b50\u9032\u5165\u81e8\u5e8a\u3002\u6211\u5011\u76f8\u4fe1\uff0cASC39\u53ef\u80fd\u63d0\u4f9b\u8207\u79ae\u4f86\uff08Eli Lilly\uff09\u7684eloralintide\u76f8\u4f3c\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff0c\u540c\u6642\u5177\u5099\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u5c0f\u5206\u5b50\u5c0d\u60a3\u8005\u7684\u4fbf\u5229\u6027\uff0c\u4ee5\u53ca\u5546\u696d\u898f\u6a21\u5316\u6f5b\u529b\u3002\u300d ASC39\u662f\u4e00\u7a2e\u5c0d\u80f0\u6fb1\u7d20\u5177\u6709\u9078\u64c7\u6027\u7684\u5f37\u6548\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u6b63\u5728\u65e2\u4f5c\u70ba\u55ae\u85e5\u958b\u767c\uff0c\u4e5f\u4f5c\u70ba\u8207ASC30\u806f\u7528\uff08ASC30\u70ba\u6b4c\u79ae\u53e3\u670d\u5c0f\u5206\u5b50\u3001\u5df2\u5177\u5099III\u671f\u689d\u4ef6\u7684GLP-1\u5019\u9078\u85e5\u7269\uff09\u958b\u767c\uff0c\u4ee5\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u8a72\u65b0\u578b\u53e3\u670d\u5c0f\u5206\u5b50\u80f0\u6fb1\u7d20\u9805\u76ee\u5f37\u5316\u4e86\u6b4c\u79ae\u73fe\u6709\u7684\u80f0\u6fb1\u7d20\u591a\u80bd\u5019\u9078\u85e5\u7269\u7d44\u5408\uff0c\u5305\u62ecASC36\uff08\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u80f0\u6fb1\u7d20\u591a\u80bd\u55ae\u85e5\u7642\u6cd5\uff09\uff0c\u4ee5\u53caASC36\u8207\u6bcf\u6708\u4e00\u6b21ASC35\uff08GLP-1\/GIP\u76ae\u4e0b\u6ce8\u5c04\u591a\u80bd\uff09\u7684\u56fa\u5b9a\u5291\u91cf\u5fa9\u65b9\u7d44\u5408\u3002 Briere DA, Qu H, Lansu K, et al. Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. Mol Metab. 2025;102:102271. doi:10.1016\/j.molmet.2025.102271 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement 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Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. 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Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. 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Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. 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Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept. Mol Metab. 2025;102:102271. doi:10.1016\/j.molmet.2025.102271 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement 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