{"id":415033,"date":"2026-03-05T20:35:00","date_gmt":"2026-03-05T12:35:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=415033"},"modified":"2026-03-05T20:35:00","modified_gmt":"2026-03-05T12:35:00","slug":"%e8%8f%af%e4%b8%8a%e7%94%9f%e9%86%ab%e8%87%aa%e4%b8%bb%e9%96%8b%e7%99%bc%e6%8a%97%e7%99%8c%e6%96%b0%e8%97%a5gntbm-38%e7%8d%b2%e5%be%97%e7%be%8e%e5%9c%8bfda%e8%87%a8%e5%ba%8a%e4%b8%80%e6%9c%9f%e8%a9%a6","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=415033","title":{"rendered":"\u83ef\u4e0a\u751f\u91ab\u81ea\u4e3b\u958b\u767c\u6297\u764c\u65b0\u85e5GNTbm-38\u7372\u5f97\u7f8e\u570bFDA\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\u7684IND\u6838\u51c6"},"content":{"rendered":"
\n

\u53f0\u5317<\/span>2026\u5e743\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u83ef\u4e0a\u751f\u91ab\u7c21\u7a31GNTbm \uff08\u80a1\u7968\u4ee3\u78bc\uff1a7427\uff09\u5ba3\u5e03\u5176\u81ea\u4e3b\u958b\u767c\uff0c\u64c1\u6709\u5168\u7403\u958b\u767c\u6b0a\u5229\uff0c\u7528\u65bc\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u5168\u65b0\u8868\u89c0\u907a\u50b3\u514d\u75ab\u6d3b\u5316\u5291GNTbm-38\u7684\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\uff0c\u905e\u4ea4\u7f8e\u570bFDA\u7684IND\u7533\u8acb\u7372\u5f97\u6838\u51c6\uff0c\u5c07\u5728\u7f8e\u570b\u9032\u884c\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\u7684\u6536\u6848\u3002<\/p>\n

\u81e8\u5e8a\u8a66\u9a57\u984c\u76ee: A Phase 1a\/1b, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of GNTbm<\/i>\u2011<\/i>38<\/i>\u00a0in<\/i>\u00a0Adult<\/i>\u00a0Patients<\/i>\u00a0with <\/i>Advanced<\/i>\u00a0Solid<\/i>\u00a0Tumors<\/i>\u00a0and <\/i>Relapsed\/Refractory <\/i>Peripheral<\/i>\u00a0T-Cell <\/i>Lymphoma.<\/i><\/p>\n

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\u83ef\u4e0a\u751f\u91ab\u7684\u7814\u767c\u5718\u968a\u4ee5\u300c\u53f0\u7063\u5275\u65b0\u7814\u767c \u9020\u798f\u5168\u7403\u665a\u671f\u764c\u75c7\u75c5\u60a3\u300d\u7684\u65b0\u85e5\u7814\u767c\u4fe1\u5ff5\uff0c\u4e0d\u65b7\u7684\u7cbe\u76ca\u6c42\u7cbe\uff0c\u5275\u65b0\u7814\u767c\u300c\u65b0\u4e00\u4ee3\u7684\u8868\u89c0\u907a\u50b3\u514d\u75ab\u6d3b\u5316\u96d9\u529f\u80fd\u6027\u85e5\u7269\u300d—GNTbm-38\u3002GNTbm-38\u5df2\u7d93\u7533\u8acb\u5168\u7403\u591a\u570b\u767c\u660e\u5c08\u5229\uff0c\u4e26\u5df2\u7372\u5f9740\u500b\u570b\u5bb6\u6838\u51c6\u5c08\u5229\u3002GNTbm-38\u5177\u6709\u975e\u5e38\u512a\u8d8a\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u4e3b\u8981\u4f86\u81ea\u5176\u7368\u7279\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u6a5f\u5236\uff0c\u53ef\u4ee5\u986f\u8457\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7d71\uff0c\u7372\u5f97\u975e\u5e38\u512a\u8d8a\u7684\u6297\u816b\u7624\u514d\u75ab\u6d3b\u6027\u3002\u57282025\u5e74\uff0cGNTbm-38\u5df2\u5728ASCO\u767c\u8868\u7814\u7a76\u5831\u544a\uff1b\u4e26\u5728\u540c\u5e74\u7372\u5f97\u7b2c22\u5c46\u53f0\u7063\u570b\u5bb6\u65b0\u5275\u734e\u80af\u5b9a\uff0c\u672c\u6b21\u518d\u7372\u5f97\u7f8e\u570bFDA\u7684IND\u6838\u51c6\uff0c\u5c0d\u83ef\u4e0a\u751f\u91ab\u7684\u7814\u767c\u5718\u968a\u5177\u6709\u83ab\u5927\u9f13\u821e\u4f5c\u7528\u3002\u83ef\u4e0a\u751f\u91ab\u5c07\u651c\u624b\u570b\u969b\u4e0a\u6709\u8c50\u5bcc\u7d93\u9a57\u7684CRO\u516c\u53f8\u5408\u4f5c\uff0c\u63a8\u9032GNTbm-38\u9032\u5165\u4ee5\u7f8e\u570b\u3001\u4e2d\u570b\u53ca\u53f0\u7063\u70ba\u4e3b\u7684\u5168\u7403\u591a\u570b\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6536\u6848\uff0c\u5e0c\u671b\u80fd\u63d0\u4f9b\u665a\u671f\u764c\u75c7\u75c5\u60a3\u7684\u65b0\u6cbb\u7642\u9078\u64c7\u3002<\/p>\n

\u83ef\u4e0a\u751f\u91ab\u8463\u4e8b\u9577\u9673\u5609\u5357\u535a\u58eb\u8868\u793a: \u300cGNTbm-38\u662f\u83ef\u4e0a\u751f\u91ab\u7814\u767c\u5718\u968a\u5728\u524b\u5fc5\u9054\u65b0\u85e5\u958b\u767c\u591a\u5e74\u5f8c\uff0c\u81ea\u4e3b\u958b\u767c\u7684\u65b0\u4e00\u4ee3\u6297\u816b\u7624\u514d\u75ab\u6cbb\u7642\u7684\u65b0\u85e5\u300d\u3002GNTbm-38\u662f\u53f0\u7063\u81ea\u4e3b\u958b\u767c\u7684\u5168\u65b0\u7d50\u69cb\u3001\u53e3\u670d\u3001\u65b0\u6210\u5206\u65b0\u85e5\u3002GNTbm-38\u5177\u6709\u975e\u5e38\u512a\u7570\u7684\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u53ca\u514d\u75ab\u6d3b\u5316\u6a5f\u5236\uff0c\u53ef\u63a7\u5236\u57fa\u56e0\u7684\u8868\u9054\u958b\u95dc\uff0c\u66f4\u6df1\u5c64\u5f71\u97ff\u57fa\u56e0\u8207\u86cb\u767d\u8cea\u7684\u8868\u73fe\u3002\u83ef\u4e0a\u751f\u91ab\u7684\u7814\u767c\u5718\u968a\u5df2\u7d93\u898f\u5283GNTbm-38\u7684\u81e8\u5e8a\u591a\u500b\u9069\u61c9\u75c7\u958b\u767c\u7b56\u7565\uff0c\u5c07\u512a\u5148\u958b\u767c\u5fa9\u767c\u6216\u96e3\u6cbb\u7684\u5916\u5468T\u7d30\u80de\u6dcb\u5df4\u764c\uff0c\u53d6\u5f97\u5b64\u5152\u85e5\u6388\u4e88\u8cc7\u683c\uff1b\u518d\u64f4\u589e\u65b0\u9069\u61c9\u75c7\u3002GNTbm-38\u662f\u5c6c\u65bc\u4e00\u500b\u5ee3\u666e\u6027\u3001\u53e3\u670d\u3001\u6297\u764c\u65b0\u85e5\uff0c\u958b\u767c\u6f5b\u529b\u5de8\u5927\uff0c\u53ef\u4ee5\u8207\u591a\u7a2e\u4e0d\u540c\u6a5f\u5236\u85e5\u7269\u806f\u5408\u4f7f\u7528\uff0c\u53ef\u806f\u5408\u7684\u7528\u85e5\u5305\u62ec\u7368\u7279\u7684\u591a\u91cd\u6fc0\u9176\u6291\u5236\u5291\u3001\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u6216anti-PD-1\/VEGF\u96d9\u7279\u7570\u6027\u6297\u9ad4\u7b49\u85e5\u7269\uff0c\u7522\u751f\u66f4\u5f37\u5927\u7684\u5354\u540c\u6027\u6297\u764c\u7642\u6548\uff0c\u63d0\u4f9b\u75c5\u60a3\u66f4\u597d\u7684\u6cbb\u7642\u6548\u76ca\u3002<\/p>\n

\u95dc\u65bc<\/b>GNTbm-38<\/b><\/p>\n

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\u95dc\u65bc\u83ef\u4e0a\u751f\u91ab<\/b><\/p>\n

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\u65b0\u805e\u767c\u8a00\u4eba\uff1a\u83ef\u4e0a\u751f\u6280\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8d99\u6708\u79c0\u8cc7\u6df1\u526f\u7e3d\u7d93\u7406E mail: yesu.chao@gntbm.com.tw\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=415033\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u83ef\u4e0a\u751f\u91ab\u81ea\u4e3b\u958b\u767c\u6297\u764c\u65b0\u85e5GNTbm-38\u7372\u5f97\u7f8e\u570bFDA\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\u7684IND\u6838\u51c6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u53f0\u53172026\u5e743\u67085\u65e5 \/\u7f8e\u901a\u793e\/ -- \u83ef\u4e0a\u751f\u91ab\u7c21\u7a31GNTbm \uff08\u80a1\u7968\u4ee3\u78bc\uff1a7427\uff09\u5ba3\u5e03\u5176\u81ea\u4e3b\u958b\u767c\uff0c\u64c1\u6709\u5168\u7403\u958b\u767c\u6b0a\u5229\uff0c\u7528\u65bc\u764c\u75c7\u514d\u75ab\u7642\u6cd5\u7684\u5168\u65b0\u8868\u89c0\u907a\u50b3\u514d\u75ab\u6d3b\u5316\u5291GNTbm-38\u7684\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\uff0c\u905e\u4ea4\u7f8e\u570bFDA\u7684IND\u7533\u8acb\u7372\u5f97\u6838\u51c6\uff0c\u5c07\u5728\u7f8e\u570b\u9032\u884c\u81e8\u5e8a\u4e00\u671f\u8a66\u9a57\u7684\u6536\u6848\u3002 \u81e8\u5e8a\u8a66\u9a57\u984c\u76ee: A Phase 1a\/1b, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of GNTbm\u201138\u00a0in\u00a0Adult\u00a0Patients\u00a0with Advanced\u00a0Solid\u00a0Tumors\u00a0and Relapsed\/Refractory Peripheral\u00a0T-Cell Lymphoma. 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GNTbm-38\u662f\u83ef\u4e0a\u751f\u91ab\u7814\u767c\u5718\u968a\u5728\u8868\u89c0\u907a\u50b3\u53ca\u816b\u7624\u514d\u75ab\u6cbb\u7642\u9818\u57df\u591a\u5e74\u7684\u7814\u7a76\u5fc3\u8840\u7d50\u6676\uff0c\u5df2\u7d93\u7d2f\u7a4d\u8d85\u904e1\u842c\u9801\u7684\u7814\u7a76\u5831\u544a\uff0c\u4e26\u9806\u5229\u7372\u5f97\u7f8e\u570bFDA\u7684IND\u6838\u51c6\uff0c\u662f\u83ef\u4e0a\u751f\u91ab\u7e7c\u5728\u53f0\u7063\u958b\u767c\u6210\u529f\u4e26\u570b\u7522\u88fd\u9020\u4e4b\u5df2\u4e0a\u5e02\u6297\u764c\u65b0\u85e5\u300c\u524b\u5fc5\u9054\u300d\u4e4b\u5f8c\uff0c\u53e6\u4e00\u500b\u975e\u5e38\u6709\u50f9\u503c\u8207\u610f\u7fa9\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \u83ef\u4e0a\u751f\u91ab\u7684\u7814\u767c\u5718\u968a\u4ee5\u300c\u53f0\u7063\u5275\u65b0\u7814\u767c 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