{"id":410182,"date":"2026-02-11T22:11:00","date_gmt":"2026-02-11T14:11:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=410182"},"modified":"2026-02-11T22:11:00","modified_gmt":"2026-02-11T14:11:00","slug":"irbm-%e5%85%ac%e5%b8%83%e5%af%a8%e5%8d%a1%e7%97%85%e6%af%92%e8%97%a5%e7%89%a9%e7%a0%94%e7%99%bc%e5%8f%96%e5%be%97%e7%aa%81%e7%a0%b4","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=410182","title":{"rendered":"IRBM \u516c\u5e03\u5be8\u5361\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u53d6\u5f97\u7a81\u7834"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mma.prnasia.com\/media2\/2656507\/IRBM_Logo.jpg?p=medium600\" border=\"0\" alt=\"\" title=\"logo\" hspace=\"0\" vspace=\"0\" width=\"118\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legendSpanClass\">\u7f85\u99ac<\/span><span class=\"legendSpanClass\">2026\u5e742\u670811\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u65e9\u671f\u85e5\u7269\u7814\u767c\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u8005 IRBM \u5ba3\u4f48\u4e00\u9805\u91cd\u5927\u79d1\u5b78\u7a81\u7834\uff0c\u6210\u529f\u767c\u73fe\u4e00\u7a2e\u5168\u65b0\u4e14\u5177\u9ad8\u6548\u529b\u7684\u8b8a\u69cb\u578b\u6291\u5236\u5291\uff0c\u4ee5\u6a19\u9776\u5f62\u5f0f\u91dd\u5c0d\u5be8\u5361\u75c5\u6bd2 (Zika virus\uff0cZIKV) \u7684\u86cb\u767d\u9176 (NS2B-NS3)\u3002 \u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u00a0<i>Nature Communications<\/i> \uff08doi\uff1a10.1038\/s41467-026-68943-x\uff09\uff0c\u7d50\u679c\u986f\u793a\u8a72\u5206\u5b50\u65bc\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u5177\u5099\u986f\u8457\u7642\u6548\uff0c\u70ba\u5c0d\u6297\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6975\u5177\u524d\u666f\u7684\u65b0\u7b56\u7565\u3002<\/p>\n<div id=\"prni_dvprnejpgc0d7left\" dir=\"ltr\" style=\"TEXT-ALIGN: center; WIDTH: 100%\">   <span>Visualization of how IRBM-Z-2 binds to a newly discovered pocket on the Zika virus protease, revealing key interactions that may help block the virus\u2019s activity.<\/span>  <\/div>\n<p>\u7d93\u868a\u5b50\u50b3\u64ad\u7684\u5be8\u5361\u75c5\u6bd2\u00a0(ZIKV) \u56e0\u8207\u56b4\u91cd\u795e\u7d93\u7cfb\u7d71\u4f75\u767c\u75c7\u76f8\u95dc\uff0c\u5c0d\u516c\u5171\u885e\u751f\u69cb\u6210\u91cd\u5927\u5a01\u8105\u3002 \u76ee\u524d\u5c1a\u7121\u7372\u6279\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u6216\u75ab\u82d7\uff0c\u5c0d\u5168\u65b0\u7684\u6cbb\u7642\u65b9\u6848\u5b58\u5728\u8feb\u5207\u9700\u6c42\u3002<\/p>\n<p>IRBM \u79d1\u5b78\u5bb6\u767c\u73fe\u4e00\u7a2e\u5c0f\u5206\u5b50\uff0c\u80fd\u8207\u00a0<b>NS2B-NS3 <\/b><b>\u86cb\u767d<\/b><b>\u9176\u4e0a\u4e00\u500b\u6b64\u524d<\/b><b>\u5c1a\u672a\u88ab\u8868\u5fb5\u7684\u8b8a\u69cb\u4f4d\u9ede\u7d50\u5408\uff0c<\/b>\u800c\u8a72\u86cb\u767d\u9176\u662f\u75c5\u6bd2\u8907\u88fd\u6240\u9700\u7684\u95dc\u9375\u9176\u3002 \u8a72\u6291\u5236\u5291\u5728\u751f\u5316\u53ca\u7d30\u80de\u5be6\u9a57\u4e2d\u80fd\u6709\u6548\u6291\u5236\u86cb\u767d\u9176\u6d3b\u6027\uff0c\u4e26\u5728\u00a0<b>\u52d5\u7269\u6a21\u578b\u4e2d\u5c55\u73fe\u986f\u8457\u7684\u6297\u75c5\u6bd2\u6d3b\u6027<\/b>\u3002 \u6b64\u5916\uff0c\u5b83\u4ea6\u5448\u73fe\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\uff0c\u652f\u6301\u5176\u9032\u4e00\u6b65\u9032\u884c\u81e8\u5e8a\u958b\u767c\u7684\u6f5b\u529b\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8a72\u4f5c\u7528\u6a5f\u5236\u6216\u53ef\u5ef6\u4f38\u81f3\u00a0<b>\u5176\u4ed6\u9ec3\u75c5\u6bd2\u5c6c<\/b>\u00a0(Flaviviruses)\uff0c\u5305\u62ec\u767b\u9769\u71b1\u3001\u9ec3\u71b1\u75c5\u53ca\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\uff0c\u986f\u793a\u51fa\u00a0<b>\u66f4\u5ee3\u6cdb\u7684\u6cbb\u7642\u6f5b\u529b<\/b>\u3002<\/p>\n<p>IRBM \u63a1\u7528\u7684\u00a0<b>\u6574\u5408\u5f0f\u7814\u767c\u65b9\u6cd5<\/b>\uff0c\u7d50\u5408\u4e86\u9ad8\u5167\u6db5\u8868\u578b\u7be9\u9078\u3001\u904b\u7b97\u5efa\u6a21\u3001\u6a5f\u5236\u9175\u7d20\u5b78\u3001\u8fed\u4ee3\u85e5\u7269\u5316\u5b78\u53ca\u00a0ADME \u7279\u6027\u5206\u6790\uff0c\u4f7f\u7814\u767c\u5718\u968a\u80fd\u8fc5\u901f\u5f9e\u521d\u6b65\u7be9\u9078\u51fa\u7684\u82d7\u982d\u5316\u5408\u7269\u00a0(hit)\uff0c\u9032\u5c55\u81f3\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u9078\u5b9a\u3002<\/p>\n<p>IRBM \u79d1\u5b78\u7e3d\u76e3\u3001\u91ab\u5b78\u535a\u58eb\u53ca\u54f2\u5b78\u535a\u58eb\u00a0Carlo Toniatti \u900f\u9732\uff1a<i>\u300c\u9019\u9805\u767c\u73fe\u6a19\u8a8c\u7740\u6297\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c<\/i>\u00a0<i>\u900f\u904e\u904b\u7528\u5c16\u7aef\u85e5\u7269\u5316\u5b78\u53ca\u6574\u5408\u5f0f\u7be9\u9078\u6280\u8853\uff0c\u6211\u5011\u7684\u5718\u968a\u6210\u529f\u7814\u767c\u51fa\u4e00\u7a2e\u5177\u5099\u5f37\u52c1\u81e8\u5e8a\u524d\u6d3b\u6027\u7684\u5168\u65b0\u5be8\u5361\u75c5\u6bd2\u86cb\u767d<\/i><i>\u9176\u6291\u5236\u5291\u3002\u300d<\/i><\/p>\n<p>\u9019\u9805\u7531\u62c9\u9f4a\u5967\u5927\u5340\u00a0(Region of Lazio) \u64a5\u6b3e\u8cc7\u52a9\u7684\u6210\u679c\uff0c\u6e90\u81ea\u00a0CNCCS \u767c\u8d77\u7684\u5408\u4f5c\u7814\u7a76\u8a08\u5283\uff0c\u70ba\u958b\u767c\u5177\u91dd\u5c0d\u6027\u7684\u6297\u75c5\u6bd2\u7642\u6cd5\u958b\u555f\u4e86\u6975\u5177\u524d\u666f\u7684\u9053\u8def\uff0c\u6709\u671b\u586b\u88dc\u5168\u7403\u516c\u5171\u885e\u751f\u9632\u79a6\u65b9\u9762\u7684\u95dc\u9375\u7f3a\u53e3\u3002 \u6b64\u9805\u6210\u679c\u4ea6\u9032\u4e00\u6b65\u978f\u56fa\u00a0CNCCS \u8207\u00a0IRBM \u4ee5\u5275\u65b0\u79d1\u5b78\u61c9\u5c0d\u00a0<b>\u7f55\u898b\u548c\u88ab\u5ffd\u8996\u75be\u75c5<\/b>\u00a0\u7684\u5171\u540c\u627f\u8afe\u3002<\/p>\n<p>IRBM \u884c\u653f\u7e3d\u88c1\u517c\u5275\u8fa6\u4eba\u00a0Matteo Liguori \u88dc\u5145\u9053\uff1a<i>\u300c\u85e5\u7269\u7814\u767c\u7684\u5275\u65b0\u5f9e\u4f86\u4e0d\u662f\u5b64\u8ecd\u4f5c\u6230\u3002<\/i>\u00a0<i>\u5728 IRBM<\/i><i>\uff0c\u6211\u5011\u81f4\u529b\u6210\u70ba\u9023\u63a5\u5b78\u8853\u7814\u7a76\u6210\u679c\u8207\u81e8\u5e8a\u61c9\u7528\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u800c\u6b64\u9805\u76ee\u7684\u6210\u529f\uff0c\u6b63\u6b63\u5c55\u793a\u4e86\u6709\u6548\u7684\u516c\u79c1\u71df\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\u5728\u63a8\u52d5\u65b0\u7642\u6cd5\u767c\u5c55\u65b9\u9762\u6240\u80fd\u5e36\u4f86\u7684\u5f71\u97ff\u3002\u300d<\/i><\/p>\n<p><b>\u95dc\u65bc\u00a0IRBM\u00a0<\/b>IRBM \u662f\u4e00\u5bb6\u9818\u5148\u7684\u7814\u7a76\u6a5f\u69cb\uff0c\u5c08\u6ce8\u65bc\u65e9\u671f\u85e5\u7269\u7814\u767c\u3002 \u6191\u85c9\u6578\u5341\u5e74\u7684\u5c08\u696d\u7d93\u9a57\u53ca\u6210\u529f\u4ea4\u4ed8\u5275\u65b0\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u826f\u597d\u5f80\u7e3e\uff0cIRBM \u4ee5\u5176\u56b4\u8b39\u3001\u591a\u5b78\u79d1\u6574\u5408\u7684\u7814\u7a76\u65b9\u6cd5\u800c\u805e\u540d\uff0c\u80fd\u5920\u8a2d\u8a08\u4e26\u57f7\u884c\u8907\u96dc\u5be6\u9a57\uff0c\u4ee5\u61c9\u5c0d\u6700\u5177\u6311\u6230\u6027\u7684\u85e5\u7269\u7814\u767c\u96e3\u984c\u3002\u00a0IRBM \u5728\u591a\u5143\u6280\u8853\u5e73\u53f0\u53ca\u6cbb\u7642\u9818\u57df\u63a8\u9032\u591a\u9805\u7814\u767c\u8a08\u5283\uff0c\u6db5\u84cb\u6297\u75c5\u6bd2\u3001\u816b\u7624\u5b78\u3001\u795e\u7d93\u79d1\u5b78\u3001\u7f55\u898b\u75be\u75c5\u7b49\u7bc4\u7587\uff0c\u4e26\u6301\u7e8c\u62d3\u5c55\u81f3\u66f4\u591a\u9818\u57df\u3002<\/p>\n<p><b>\u95dc\u65bc\u00a0CNCCS\u00a0<\/b>CNCCS \u662f\u4e00\u500b\u7531\u00a0IRBM\u3001CNR\u3001ISS \u53ca\u7f85\u99ac\u5927\u5b78\u00a0(University of La Sapienza) \u7d44\u6210\u7684\u516c\u79c1\u5408\u71df\u806f\u76df\uff0c\u4f5c\u70ba\u85e5\u7269\u7814\u767c\u8a08\u5283\u7684\u6838\u5fc3\u63a8\u52d5\u5e73\u53f0\uff0c\u6574\u5408\u5316\u5b78\u5316\u5408\u7269\u8cc7\u6e90\u5eab\u8207\u9ad8\u541e\u5410\u91cf\u7be9\u9078\u00a0(HTS) \u5e73\u53f0\u3002 \u5176\u4f7f\u547d\u662f\u6210\u70ba\u9023\u63a5\u5b78\u8853\u7814\u7a76\u8207\u88fd\u85e5\u958b\u767c\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u7279\u5225\u5c08\u6ce8\u65bc\u91dd\u5c0d\u7f55\u898b\u3001\u88ab\u5ffd\u8996\u53ca\u8207\u8ca7\u56f0\u76f8\u95dc\u7684\u75be\u75c5\u3002\u00a0<\/p>\n<p>\u7db2\u7ad9\uff1a<a href=\"https:\/\/www.irbm.com\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.irbm.com<\/a>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f85\u99ac2026\u5e742\u670811\u65e5 \/\u7f8e&#8230;<\/p>\n","protected":false},"author":16,"featured_media":410183,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-410182","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>IRBM \u516c\u5e03\u5be8\u5361\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u53d6\u5f97\u7a81\u7834 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f85\u99ac2026\u5e742\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u65e9\u671f\u85e5\u7269\u7814\u767c\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u8005 IRBM \u5ba3\u4f48\u4e00\u9805\u91cd\u5927\u79d1\u5b78\u7a81\u7834\uff0c\u6210\u529f\u767c\u73fe\u4e00\u7a2e\u5168\u65b0\u4e14\u5177\u9ad8\u6548\u529b\u7684\u8b8a\u69cb\u578b\u6291\u5236\u5291\uff0c\u4ee5\u6a19\u9776\u5f62\u5f0f\u91dd\u5c0d\u5be8\u5361\u75c5\u6bd2 (Zika virus\uff0cZIKV) \u7684\u86cb\u767d\u9176 (NS2B-NS3)\u3002 \u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u00a0Nature Communications \uff08doi\uff1a10.1038\/s41467-026-68943-x\uff09\uff0c\u7d50\u679c\u986f\u793a\u8a72\u5206\u5b50\u65bc\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u5177\u5099\u986f\u8457\u7642\u6548\uff0c\u70ba\u5c0d\u6297\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6975\u5177\u524d\u666f\u7684\u65b0\u7b56\u7565\u3002      Visualization of how IRBM-Z-2 binds to a newly discovered pocket on the Zika virus protease, revealing key interactions that may help block the virus\u2019s activity.  \u7d93\u868a\u5b50\u50b3\u64ad\u7684\u5be8\u5361\u75c5\u6bd2\u00a0(ZIKV) \u56e0\u8207\u56b4\u91cd\u795e\u7d93\u7cfb\u7d71\u4f75\u767c\u75c7\u76f8\u95dc\uff0c\u5c0d\u516c\u5171\u885e\u751f\u69cb\u6210\u91cd\u5927\u5a01\u8105\u3002 \u76ee\u524d\u5c1a\u7121\u7372\u6279\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u6216\u75ab\u82d7\uff0c\u5c0d\u5168\u65b0\u7684\u6cbb\u7642\u65b9\u6848\u5b58\u5728\u8feb\u5207\u9700\u6c42\u3002 IRBM \u79d1\u5b78\u5bb6\u767c\u73fe\u4e00\u7a2e\u5c0f\u5206\u5b50\uff0c\u80fd\u8207\u00a0NS2B-NS3 \u86cb\u767d\u9176\u4e0a\u4e00\u500b\u6b64\u524d\u5c1a\u672a\u88ab\u8868\u5fb5\u7684\u8b8a\u69cb\u4f4d\u9ede\u7d50\u5408\uff0c\u800c\u8a72\u86cb\u767d\u9176\u662f\u75c5\u6bd2\u8907\u88fd\u6240\u9700\u7684\u95dc\u9375\u9176\u3002 \u8a72\u6291\u5236\u5291\u5728\u751f\u5316\u53ca\u7d30\u80de\u5be6\u9a57\u4e2d\u80fd\u6709\u6548\u6291\u5236\u86cb\u767d\u9176\u6d3b\u6027\uff0c\u4e26\u5728\u00a0\u52d5\u7269\u6a21\u578b\u4e2d\u5c55\u73fe\u986f\u8457\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 \u6b64\u5916\uff0c\u5b83\u4ea6\u5448\u73fe\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\uff0c\u652f\u6301\u5176\u9032\u4e00\u6b65\u9032\u884c\u81e8\u5e8a\u958b\u767c\u7684\u6f5b\u529b\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8a72\u4f5c\u7528\u6a5f\u5236\u6216\u53ef\u5ef6\u4f38\u81f3\u00a0\u5176\u4ed6\u9ec3\u75c5\u6bd2\u5c6c\u00a0(Flaviviruses)\uff0c\u5305\u62ec\u767b\u9769\u71b1\u3001\u9ec3\u71b1\u75c5\u53ca\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\uff0c\u986f\u793a\u51fa\u00a0\u66f4\u5ee3\u6cdb\u7684\u6cbb\u7642\u6f5b\u529b\u3002 IRBM \u63a1\u7528\u7684\u00a0\u6574\u5408\u5f0f\u7814\u767c\u65b9\u6cd5\uff0c\u7d50\u5408\u4e86\u9ad8\u5167\u6db5\u8868\u578b\u7be9\u9078\u3001\u904b\u7b97\u5efa\u6a21\u3001\u6a5f\u5236\u9175\u7d20\u5b78\u3001\u8fed\u4ee3\u85e5\u7269\u5316\u5b78\u53ca\u00a0ADME \u7279\u6027\u5206\u6790\uff0c\u4f7f\u7814\u767c\u5718\u968a\u80fd\u8fc5\u901f\u5f9e\u521d\u6b65\u7be9\u9078\u51fa\u7684\u82d7\u982d\u5316\u5408\u7269\u00a0(hit)\uff0c\u9032\u5c55\u81f3\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u9078\u5b9a\u3002 IRBM \u79d1\u5b78\u7e3d\u76e3\u3001\u91ab\u5b78\u535a\u58eb\u53ca\u54f2\u5b78\u535a\u58eb\u00a0Carlo Toniatti \u900f\u9732\uff1a\u300c\u9019\u9805\u767c\u73fe\u6a19\u8a8c\u7740\u6297\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u00a0\u900f\u904e\u904b\u7528\u5c16\u7aef\u85e5\u7269\u5316\u5b78\u53ca\u6574\u5408\u5f0f\u7be9\u9078\u6280\u8853\uff0c\u6211\u5011\u7684\u5718\u968a\u6210\u529f\u7814\u767c\u51fa\u4e00\u7a2e\u5177\u5099\u5f37\u52c1\u81e8\u5e8a\u524d\u6d3b\u6027\u7684\u5168\u65b0\u5be8\u5361\u75c5\u6bd2\u86cb\u767d\u9176\u6291\u5236\u5291\u3002\u300d \u9019\u9805\u7531\u62c9\u9f4a\u5967\u5927\u5340\u00a0(Region of Lazio) \u64a5\u6b3e\u8cc7\u52a9\u7684\u6210\u679c\uff0c\u6e90\u81ea\u00a0CNCCS \u767c\u8d77\u7684\u5408\u4f5c\u7814\u7a76\u8a08\u5283\uff0c\u70ba\u958b\u767c\u5177\u91dd\u5c0d\u6027\u7684\u6297\u75c5\u6bd2\u7642\u6cd5\u958b\u555f\u4e86\u6975\u5177\u524d\u666f\u7684\u9053\u8def\uff0c\u6709\u671b\u586b\u88dc\u5168\u7403\u516c\u5171\u885e\u751f\u9632\u79a6\u65b9\u9762\u7684\u95dc\u9375\u7f3a\u53e3\u3002 \u6b64\u9805\u6210\u679c\u4ea6\u9032\u4e00\u6b65\u978f\u56fa\u00a0CNCCS \u8207\u00a0IRBM \u4ee5\u5275\u65b0\u79d1\u5b78\u61c9\u5c0d\u00a0\u7f55\u898b\u548c\u88ab\u5ffd\u8996\u75be\u75c5\u00a0\u7684\u5171\u540c\u627f\u8afe\u3002 IRBM \u884c\u653f\u7e3d\u88c1\u517c\u5275\u8fa6\u4eba\u00a0Matteo Liguori \u88dc\u5145\u9053\uff1a\u300c\u85e5\u7269\u7814\u767c\u7684\u5275\u65b0\u5f9e\u4f86\u4e0d\u662f\u5b64\u8ecd\u4f5c\u6230\u3002\u00a0\u5728 IRBM\uff0c\u6211\u5011\u81f4\u529b\u6210\u70ba\u9023\u63a5\u5b78\u8853\u7814\u7a76\u6210\u679c\u8207\u81e8\u5e8a\u61c9\u7528\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u800c\u6b64\u9805\u76ee\u7684\u6210\u529f\uff0c\u6b63\u6b63\u5c55\u793a\u4e86\u6709\u6548\u7684\u516c\u79c1\u71df\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\u5728\u63a8\u52d5\u65b0\u7642\u6cd5\u767c\u5c55\u65b9\u9762\u6240\u80fd\u5e36\u4f86\u7684\u5f71\u97ff\u3002\u300d \u95dc\u65bc\u00a0IRBM\u00a0IRBM \u662f\u4e00\u5bb6\u9818\u5148\u7684\u7814\u7a76\u6a5f\u69cb\uff0c\u5c08\u6ce8\u65bc\u65e9\u671f\u85e5\u7269\u7814\u767c\u3002 \u6191\u85c9\u6578\u5341\u5e74\u7684\u5c08\u696d\u7d93\u9a57\u53ca\u6210\u529f\u4ea4\u4ed8\u5275\u65b0\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u826f\u597d\u5f80\u7e3e\uff0cIRBM \u4ee5\u5176\u56b4\u8b39\u3001\u591a\u5b78\u79d1\u6574\u5408\u7684\u7814\u7a76\u65b9\u6cd5\u800c\u805e\u540d\uff0c\u80fd\u5920\u8a2d\u8a08\u4e26\u57f7\u884c\u8907\u96dc\u5be6\u9a57\uff0c\u4ee5\u61c9\u5c0d\u6700\u5177\u6311\u6230\u6027\u7684\u85e5\u7269\u7814\u767c\u96e3\u984c\u3002\u00a0IRBM \u5728\u591a\u5143\u6280\u8853\u5e73\u53f0\u53ca\u6cbb\u7642\u9818\u57df\u63a8\u9032\u591a\u9805\u7814\u767c\u8a08\u5283\uff0c\u6db5\u84cb\u6297\u75c5\u6bd2\u3001\u816b\u7624\u5b78\u3001\u795e\u7d93\u79d1\u5b78\u3001\u7f55\u898b\u75be\u75c5\u7b49\u7bc4\u7587\uff0c\u4e26\u6301\u7e8c\u62d3\u5c55\u81f3\u66f4\u591a\u9818\u57df\u3002 \u95dc\u65bc\u00a0CNCCS\u00a0CNCCS \u662f\u4e00\u500b\u7531\u00a0IRBM\u3001CNR\u3001ISS \u53ca\u7f85\u99ac\u5927\u5b78\u00a0(University of La Sapienza) \u7d44\u6210\u7684\u516c\u79c1\u5408\u71df\u806f\u76df\uff0c\u4f5c\u70ba\u85e5\u7269\u7814\u767c\u8a08\u5283\u7684\u6838\u5fc3\u63a8\u52d5\u5e73\u53f0\uff0c\u6574\u5408\u5316\u5b78\u5316\u5408\u7269\u8cc7\u6e90\u5eab\u8207\u9ad8\u541e\u5410\u91cf\u7be9\u9078\u00a0(HTS) \u5e73\u53f0\u3002 \u5176\u4f7f\u547d\u662f\u6210\u70ba\u9023\u63a5\u5b78\u8853\u7814\u7a76\u8207\u88fd\u85e5\u958b\u767c\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u7279\u5225\u5c08\u6ce8\u65bc\u91dd\u5c0d\u7f55\u898b\u3001\u88ab\u5ffd\u8996\u53ca\u8207\u8ca7\u56f0\u76f8\u95dc\u7684\u75be\u75c5\u3002\u00a0 \u7db2\u7ad9\uff1awww.irbm.com\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=410182\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"IRBM \u516c\u5e03\u5be8\u5361\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u53d6\u5f97\u7a81\u7834 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f85\u99ac2026\u5e742\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u65e9\u671f\u85e5\u7269\u7814\u767c\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u8005 IRBM \u5ba3\u4f48\u4e00\u9805\u91cd\u5927\u79d1\u5b78\u7a81\u7834\uff0c\u6210\u529f\u767c\u73fe\u4e00\u7a2e\u5168\u65b0\u4e14\u5177\u9ad8\u6548\u529b\u7684\u8b8a\u69cb\u578b\u6291\u5236\u5291\uff0c\u4ee5\u6a19\u9776\u5f62\u5f0f\u91dd\u5c0d\u5be8\u5361\u75c5\u6bd2 (Zika virus\uff0cZIKV) \u7684\u86cb\u767d\u9176 (NS2B-NS3)\u3002 \u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u00a0Nature Communications \uff08doi\uff1a10.1038\/s41467-026-68943-x\uff09\uff0c\u7d50\u679c\u986f\u793a\u8a72\u5206\u5b50\u65bc\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u5177\u5099\u986f\u8457\u7642\u6548\uff0c\u70ba\u5c0d\u6297\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6975\u5177\u524d\u666f\u7684\u65b0\u7b56\u7565\u3002      Visualization of how IRBM-Z-2 binds to a newly discovered pocket on the Zika virus protease, revealing key interactions that may help block the virus\u2019s activity.  \u7d93\u868a\u5b50\u50b3\u64ad\u7684\u5be8\u5361\u75c5\u6bd2\u00a0(ZIKV) \u56e0\u8207\u56b4\u91cd\u795e\u7d93\u7cfb\u7d71\u4f75\u767c\u75c7\u76f8\u95dc\uff0c\u5c0d\u516c\u5171\u885e\u751f\u69cb\u6210\u91cd\u5927\u5a01\u8105\u3002 \u76ee\u524d\u5c1a\u7121\u7372\u6279\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u6216\u75ab\u82d7\uff0c\u5c0d\u5168\u65b0\u7684\u6cbb\u7642\u65b9\u6848\u5b58\u5728\u8feb\u5207\u9700\u6c42\u3002 IRBM \u79d1\u5b78\u5bb6\u767c\u73fe\u4e00\u7a2e\u5c0f\u5206\u5b50\uff0c\u80fd\u8207\u00a0NS2B-NS3 \u86cb\u767d\u9176\u4e0a\u4e00\u500b\u6b64\u524d\u5c1a\u672a\u88ab\u8868\u5fb5\u7684\u8b8a\u69cb\u4f4d\u9ede\u7d50\u5408\uff0c\u800c\u8a72\u86cb\u767d\u9176\u662f\u75c5\u6bd2\u8907\u88fd\u6240\u9700\u7684\u95dc\u9375\u9176\u3002 \u8a72\u6291\u5236\u5291\u5728\u751f\u5316\u53ca\u7d30\u80de\u5be6\u9a57\u4e2d\u80fd\u6709\u6548\u6291\u5236\u86cb\u767d\u9176\u6d3b\u6027\uff0c\u4e26\u5728\u00a0\u52d5\u7269\u6a21\u578b\u4e2d\u5c55\u73fe\u986f\u8457\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 \u6b64\u5916\uff0c\u5b83\u4ea6\u5448\u73fe\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\uff0c\u652f\u6301\u5176\u9032\u4e00\u6b65\u9032\u884c\u81e8\u5e8a\u958b\u767c\u7684\u6f5b\u529b\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8a72\u4f5c\u7528\u6a5f\u5236\u6216\u53ef\u5ef6\u4f38\u81f3\u00a0\u5176\u4ed6\u9ec3\u75c5\u6bd2\u5c6c\u00a0(Flaviviruses)\uff0c\u5305\u62ec\u767b\u9769\u71b1\u3001\u9ec3\u71b1\u75c5\u53ca\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\uff0c\u986f\u793a\u51fa\u00a0\u66f4\u5ee3\u6cdb\u7684\u6cbb\u7642\u6f5b\u529b\u3002 IRBM \u63a1\u7528\u7684\u00a0\u6574\u5408\u5f0f\u7814\u767c\u65b9\u6cd5\uff0c\u7d50\u5408\u4e86\u9ad8\u5167\u6db5\u8868\u578b\u7be9\u9078\u3001\u904b\u7b97\u5efa\u6a21\u3001\u6a5f\u5236\u9175\u7d20\u5b78\u3001\u8fed\u4ee3\u85e5\u7269\u5316\u5b78\u53ca\u00a0ADME \u7279\u6027\u5206\u6790\uff0c\u4f7f\u7814\u767c\u5718\u968a\u80fd\u8fc5\u901f\u5f9e\u521d\u6b65\u7be9\u9078\u51fa\u7684\u82d7\u982d\u5316\u5408\u7269\u00a0(hit)\uff0c\u9032\u5c55\u81f3\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u9078\u5b9a\u3002 IRBM \u79d1\u5b78\u7e3d\u76e3\u3001\u91ab\u5b78\u535a\u58eb\u53ca\u54f2\u5b78\u535a\u58eb\u00a0Carlo Toniatti \u900f\u9732\uff1a\u300c\u9019\u9805\u767c\u73fe\u6a19\u8a8c\u7740\u6297\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u00a0\u900f\u904e\u904b\u7528\u5c16\u7aef\u85e5\u7269\u5316\u5b78\u53ca\u6574\u5408\u5f0f\u7be9\u9078\u6280\u8853\uff0c\u6211\u5011\u7684\u5718\u968a\u6210\u529f\u7814\u767c\u51fa\u4e00\u7a2e\u5177\u5099\u5f37\u52c1\u81e8\u5e8a\u524d\u6d3b\u6027\u7684\u5168\u65b0\u5be8\u5361\u75c5\u6bd2\u86cb\u767d\u9176\u6291\u5236\u5291\u3002\u300d \u9019\u9805\u7531\u62c9\u9f4a\u5967\u5927\u5340\u00a0(Region of Lazio) \u64a5\u6b3e\u8cc7\u52a9\u7684\u6210\u679c\uff0c\u6e90\u81ea\u00a0CNCCS \u767c\u8d77\u7684\u5408\u4f5c\u7814\u7a76\u8a08\u5283\uff0c\u70ba\u958b\u767c\u5177\u91dd\u5c0d\u6027\u7684\u6297\u75c5\u6bd2\u7642\u6cd5\u958b\u555f\u4e86\u6975\u5177\u524d\u666f\u7684\u9053\u8def\uff0c\u6709\u671b\u586b\u88dc\u5168\u7403\u516c\u5171\u885e\u751f\u9632\u79a6\u65b9\u9762\u7684\u95dc\u9375\u7f3a\u53e3\u3002 \u6b64\u9805\u6210\u679c\u4ea6\u9032\u4e00\u6b65\u978f\u56fa\u00a0CNCCS \u8207\u00a0IRBM \u4ee5\u5275\u65b0\u79d1\u5b78\u61c9\u5c0d\u00a0\u7f55\u898b\u548c\u88ab\u5ffd\u8996\u75be\u75c5\u00a0\u7684\u5171\u540c\u627f\u8afe\u3002 IRBM \u884c\u653f\u7e3d\u88c1\u517c\u5275\u8fa6\u4eba\u00a0Matteo Liguori \u88dc\u5145\u9053\uff1a\u300c\u85e5\u7269\u7814\u767c\u7684\u5275\u65b0\u5f9e\u4f86\u4e0d\u662f\u5b64\u8ecd\u4f5c\u6230\u3002\u00a0\u5728 IRBM\uff0c\u6211\u5011\u81f4\u529b\u6210\u70ba\u9023\u63a5\u5b78\u8853\u7814\u7a76\u6210\u679c\u8207\u81e8\u5e8a\u61c9\u7528\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u800c\u6b64\u9805\u76ee\u7684\u6210\u529f\uff0c\u6b63\u6b63\u5c55\u793a\u4e86\u6709\u6548\u7684\u516c\u79c1\u71df\u5408\u4f5c\u5925\u4f34\u95dc\u4fc2\u5728\u63a8\u52d5\u65b0\u7642\u6cd5\u767c\u5c55\u65b9\u9762\u6240\u80fd\u5e36\u4f86\u7684\u5f71\u97ff\u3002\u300d \u95dc\u65bc\u00a0IRBM\u00a0IRBM \u662f\u4e00\u5bb6\u9818\u5148\u7684\u7814\u7a76\u6a5f\u69cb\uff0c\u5c08\u6ce8\u65bc\u65e9\u671f\u85e5\u7269\u7814\u767c\u3002 \u6191\u85c9\u6578\u5341\u5e74\u7684\u5c08\u696d\u7d93\u9a57\u53ca\u6210\u529f\u4ea4\u4ed8\u5275\u65b0\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u826f\u597d\u5f80\u7e3e\uff0cIRBM \u4ee5\u5176\u56b4\u8b39\u3001\u591a\u5b78\u79d1\u6574\u5408\u7684\u7814\u7a76\u65b9\u6cd5\u800c\u805e\u540d\uff0c\u80fd\u5920\u8a2d\u8a08\u4e26\u57f7\u884c\u8907\u96dc\u5be6\u9a57\uff0c\u4ee5\u61c9\u5c0d\u6700\u5177\u6311\u6230\u6027\u7684\u85e5\u7269\u7814\u767c\u96e3\u984c\u3002\u00a0IRBM \u5728\u591a\u5143\u6280\u8853\u5e73\u53f0\u53ca\u6cbb\u7642\u9818\u57df\u63a8\u9032\u591a\u9805\u7814\u767c\u8a08\u5283\uff0c\u6db5\u84cb\u6297\u75c5\u6bd2\u3001\u816b\u7624\u5b78\u3001\u795e\u7d93\u79d1\u5b78\u3001\u7f55\u898b\u75be\u75c5\u7b49\u7bc4\u7587\uff0c\u4e26\u6301\u7e8c\u62d3\u5c55\u81f3\u66f4\u591a\u9818\u57df\u3002 \u95dc\u65bc\u00a0CNCCS\u00a0CNCCS \u662f\u4e00\u500b\u7531\u00a0IRBM\u3001CNR\u3001ISS \u53ca\u7f85\u99ac\u5927\u5b78\u00a0(University of La Sapienza) \u7d44\u6210\u7684\u516c\u79c1\u5408\u71df\u806f\u76df\uff0c\u4f5c\u70ba\u85e5\u7269\u7814\u767c\u8a08\u5283\u7684\u6838\u5fc3\u63a8\u52d5\u5e73\u53f0\uff0c\u6574\u5408\u5316\u5b78\u5316\u5408\u7269\u8cc7\u6e90\u5eab\u8207\u9ad8\u541e\u5410\u91cf\u7be9\u9078\u00a0(HTS) \u5e73\u53f0\u3002 \u5176\u4f7f\u547d\u662f\u6210\u70ba\u9023\u63a5\u5b78\u8853\u7814\u7a76\u8207\u88fd\u85e5\u958b\u767c\u4e4b\u9593\u7684\u6a4b\u6a11\uff0c\u7279\u5225\u5c08\u6ce8\u65bc\u91dd\u5c0d\u7f55\u898b\u3001\u88ab\u5ffd\u8996\u53ca\u8207\u8ca7\u56f0\u76f8\u95dc\u7684\u75be\u75c5\u3002\u00a0 \u7db2\u7ad9\uff1awww.irbm.com\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=410182\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-11T14:11:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnasia.com\/media2\/2656507\/IRBM_Logo.jpg?p=medium600\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=410182#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=410182\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"IRBM 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\u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u00a0Nature Communications \uff08doi\uff1a10.1038\\\/s41467-026-68943-x\uff09\uff0c\u7d50\u679c\u986f\u793a\u8a72\u5206\u5b50\u65bc\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u5177\u5099\u986f\u8457\u7642\u6548\uff0c\u70ba\u5c0d\u6297\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6975\u5177\u524d\u666f\u7684\u65b0\u7b56\u7565\u3002 Visualization of how IRBM-Z-2 binds to a newly discovered pocket on the Zika virus protease, revealing key interactions that may help block the virus\u2019s activity. \u7d93\u868a\u5b50\u50b3\u64ad\u7684\u5be8\u5361\u75c5\u6bd2\u00a0(ZIKV) \u56e0\u8207\u56b4\u91cd\u795e\u7d93\u7cfb\u7d71\u4f75\u767c\u75c7\u76f8\u95dc\uff0c\u5c0d\u516c\u5171\u885e\u751f\u69cb\u6210\u91cd\u5927\u5a01\u8105\u3002 \u76ee\u524d\u5c1a\u7121\u7372\u6279\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u6216\u75ab\u82d7\uff0c\u5c0d\u5168\u65b0\u7684\u6cbb\u7642\u65b9\u6848\u5b58\u5728\u8feb\u5207\u9700\u6c42\u3002 IRBM \u79d1\u5b78\u5bb6\u767c\u73fe\u4e00\u7a2e\u5c0f\u5206\u5b50\uff0c\u80fd\u8207\u00a0NS2B-NS3 \u86cb\u767d\u9176\u4e0a\u4e00\u500b\u6b64\u524d\u5c1a\u672a\u88ab\u8868\u5fb5\u7684\u8b8a\u69cb\u4f4d\u9ede\u7d50\u5408\uff0c\u800c\u8a72\u86cb\u767d\u9176\u662f\u75c5\u6bd2\u8907\u88fd\u6240\u9700\u7684\u95dc\u9375\u9176\u3002 \u8a72\u6291\u5236\u5291\u5728\u751f\u5316\u53ca\u7d30\u80de\u5be6\u9a57\u4e2d\u80fd\u6709\u6548\u6291\u5236\u86cb\u767d\u9176\u6d3b\u6027\uff0c\u4e26\u5728\u00a0\u52d5\u7269\u6a21\u578b\u4e2d\u5c55\u73fe\u986f\u8457\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u3002 \u6b64\u5916\uff0c\u5b83\u4ea6\u5448\u73fe\u826f\u597d\u7684\u5b89\u5168\u6027\u53ca\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\uff0c\u652f\u6301\u5176\u9032\u4e00\u6b65\u9032\u884c\u81e8\u5e8a\u958b\u767c\u7684\u6f5b\u529b\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8a72\u4f5c\u7528\u6a5f\u5236\u6216\u53ef\u5ef6\u4f38\u81f3\u00a0\u5176\u4ed6\u9ec3\u75c5\u6bd2\u5c6c\u00a0(Flaviviruses)\uff0c\u5305\u62ec\u767b\u9769\u71b1\u3001\u9ec3\u71b1\u75c5\u53ca\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\uff0c\u986f\u793a\u51fa\u00a0\u66f4\u5ee3\u6cdb\u7684\u6cbb\u7642\u6f5b\u529b\u3002 IRBM \u63a1\u7528\u7684\u00a0\u6574\u5408\u5f0f\u7814\u767c\u65b9\u6cd5\uff0c\u7d50\u5408\u4e86\u9ad8\u5167\u6db5\u8868\u578b\u7be9\u9078\u3001\u904b\u7b97\u5efa\u6a21\u3001\u6a5f\u5236\u9175\u7d20\u5b78\u3001\u8fed\u4ee3\u85e5\u7269\u5316\u5b78\u53ca\u00a0ADME \u7279\u6027\u5206\u6790\uff0c\u4f7f\u7814\u767c\u5718\u968a\u80fd\u8fc5\u901f\u5f9e\u521d\u6b65\u7be9\u9078\u51fa\u7684\u82d7\u982d\u5316\u5408\u7269\u00a0(hit)\uff0c\u9032\u5c55\u81f3\u81e8\u5e8a\u524d\u5019\u9078\u85e5\u7269\u7684\u9078\u5b9a\u3002 IRBM \u79d1\u5b78\u7e3d\u76e3\u3001\u91ab\u5b78\u535a\u58eb\u53ca\u54f2\u5b78\u535a\u58eb\u00a0Carlo Toniatti \u900f\u9732\uff1a\u300c\u9019\u9805\u767c\u73fe\u6a19\u8a8c\u7740\u6297\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u00a0\u900f\u904e\u904b\u7528\u5c16\u7aef\u85e5\u7269\u5316\u5b78\u53ca\u6574\u5408\u5f0f\u7be9\u9078\u6280\u8853\uff0c\u6211\u5011\u7684\u5718\u968a\u6210\u529f\u7814\u767c\u51fa\u4e00\u7a2e\u5177\u5099\u5f37\u52c1\u81e8\u5e8a\u524d\u6d3b\u6027\u7684\u5168\u65b0\u5be8\u5361\u75c5\u6bd2\u86cb\u767d\u9176\u6291\u5236\u5291\u3002\u300d \u9019\u9805\u7531\u62c9\u9f4a\u5967\u5927\u5340\u00a0(Region of Lazio) \u64a5\u6b3e\u8cc7\u52a9\u7684\u6210\u679c\uff0c\u6e90\u81ea\u00a0CNCCS \u767c\u8d77\u7684\u5408\u4f5c\u7814\u7a76\u8a08\u5283\uff0c\u70ba\u958b\u767c\u5177\u91dd\u5c0d\u6027\u7684\u6297\u75c5\u6bd2\u7642\u6cd5\u958b\u555f\u4e86\u6975\u5177\u524d\u666f\u7684\u9053\u8def\uff0c\u6709\u671b\u586b\u88dc\u5168\u7403\u516c\u5171\u885e\u751f\u9632\u79a6\u65b9\u9762\u7684\u95dc\u9375\u7f3a\u53e3\u3002 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\u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=410182","og_locale":"zh_TW","og_type":"article","og_title":"IRBM \u516c\u5e03\u5be8\u5361\u75c5\u6bd2\u85e5\u7269\u7814\u767c\u53d6\u5f97\u7a81\u7834 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f85\u99ac2026\u5e742\u670811\u65e5 \/\u7f8e\u901a\u793e\/ -- \u65e9\u671f\u85e5\u7269\u7814\u767c\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u8005 IRBM \u5ba3\u4f48\u4e00\u9805\u91cd\u5927\u79d1\u5b78\u7a81\u7834\uff0c\u6210\u529f\u767c\u73fe\u4e00\u7a2e\u5168\u65b0\u4e14\u5177\u9ad8\u6548\u529b\u7684\u8b8a\u69cb\u578b\u6291\u5236\u5291\uff0c\u4ee5\u6a19\u9776\u5f62\u5f0f\u91dd\u5c0d\u5be8\u5361\u75c5\u6bd2 (Zika virus\uff0cZIKV) \u7684\u86cb\u767d\u9176 (NS2B-NS3)\u3002 \u76f8\u95dc\u7814\u7a76\u6210\u679c\u5df2\u767c\u8868\u65bc\u00a0Nature Communications 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