{"id":408410,"date":"2026-02-06T17:00:00","date_gmt":"2026-02-06T09:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=408410"},"modified":"2026-02-06T17:00:00","modified_gmt":"2026-02-06T09:00:00","slug":"%e7%a0%b4%e5%b1%80hr-her2-%e4%b9%b3%e8%85%ba%e7%99%8c%ef%bc%81%e8%98%86%e5%ba%b7%e6%b2%99%e5%a6%a5%e7%8f%a0%e5%96%ae%e6%8a%97sac-tmt%e7%8d%b2%e6%89%b9%e7%ac%ac%e5%9b%9b%e9%a0%85%e9%81%a9%e6%87%89","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=408410","title":{"rendered":"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u6210\u90fd<\/span>2026\u5e742\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u56db\u5ddd\u79d1\u502b\u535a\u6cf0<\/span>\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(“\u79d1\u502b\u535a\u6cf0”\u6216”\u516c\u53f8”\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae<\/sup>)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002<\/p>\n

\n<\/p><\/div>\n

\u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078<\/span>\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002<\/p>\n

OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002<\/p>\n

\u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f<\/b>(PFS)<\/b>\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584<\/b>(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684<\/b>PFS<\/b>\u7372\u76ca<\/b>\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)<\/span><\/b>\u3002[1]<\/sup><\/p>\n

\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae[2]<\/sup>)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002<\/p>\n

\u95dc\u65bc<\/u><\/b>HR+\/HER2-<\/u><\/b>\u4e73\u817a\u764c<\/u><\/b><\/p>\n

\u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002<\/p>\n

\u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297<\/u><\/b>(sac-TMT)(<\/u><\/b>\u4f73\u6cf0\u840a<\/u><\/b>\u00ae<\/sup><\/u>)<\/u><\/b><\/p>\n

\u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002<\/p>\n

\u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002<\/p>\n

\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002<\/p>\n

\u95dc\u65bc\u79d1\u502b\u535a\u6cf0<\/u><\/b><\/p>\n

\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31”\u79d1\u502b\u535a\u6cf0”\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM<\/sup>\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002<\/p>\n

\n\n\n\n\n\n
\n

[1] Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2] \u53ef\u745e\u9054\u00ae<\/sup>\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6210\u90fd2026\u5e742\u67086\u65e5 \/\u7f8e\u901a…<\/p>\n","protected":false},"author":16,"featured_media":408411,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-408410","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u6210\u90fd2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8("\u79d1\u502b\u535a\u6cf0"\u6216"\u516c\u53f8"\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002 \u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002 OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002 \u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684PFS\u7372\u76ca\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)\u3002 \u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002 \u95dc\u65bcHR+\/HER2-\u4e73\u817a\u764c \u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002 \u95dc\u65bc\u79d1\u502b\u535a\u6cf0 \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31"\u79d1\u502b\u535a\u6cf0"\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002 Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23. \u53ef\u745e\u9054\u00ae\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=408410\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u6210\u90fd2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8("\u79d1\u502b\u535a\u6cf0"\u6216"\u516c\u53f8"\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002 \u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002 OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002 \u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684PFS\u7372\u76ca\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)\u3002 \u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002 \u95dc\u65bcHR+\/HER2-\u4e73\u817a\u764c \u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002 \u95dc\u65bc\u79d1\u502b\u535a\u6cf0 \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31"\u79d1\u502b\u535a\u6cf0"\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002 Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23. \u53ef\u745e\u9054\u00ae\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=408410\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-06T09:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1706\" \/>\n\t<meta property=\"og:image:height\" content=\"960\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u7834\u5c40HR+\\\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7\",\"datePublished\":\"2026-02-06T09:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410\"},\"wordCount\":153,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/logo_kelun_Biotech_Logo.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410\",\"name\":\"\u7834\u5c40HR+\\\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/logo_kelun_Biotech_Logo.jpg\",\"datePublished\":\"2026-02-06T09:00:00+00:00\",\"description\":\"\u6210\u90fd2026\u5e742\u67086\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\\\"\u79d1\u502b\u535a\u6cf0\\\"\u6216\\\"\u516c\u53f8\\\"\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\\\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\\\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\\\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002 \u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002 OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\\\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\\\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\\\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002 \u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684PFS\u7372\u76ca\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\\\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\\\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)\u3002 \u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\\\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\\\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002 \u95dc\u65bcHR+\\\/HER2-\u4e73\u817a\u764c \u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\\\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\\\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\\\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\\\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\\\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002 \u95dc\u65bc\u79d1\u502b\u535a\u6cf0 \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31\\\"\u79d1\u502b\u535a\u6cf0\\\"\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002 Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23. \u53ef\u745e\u9054\u00ae\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/logo_kelun_Biotech_Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/logo_kelun_Biotech_Logo.jpg\",\"width\":400,\"height\":116},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408410#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u7834\u5c40HR+\\\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u6210\u90fd2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\"\u79d1\u502b\u535a\u6cf0\"\u6216\"\u516c\u53f8\"\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002 \u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002 OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002 \u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684PFS\u7372\u76ca\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)\u3002 \u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002 \u95dc\u65bcHR+\/HER2-\u4e73\u817a\u764c \u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002 \u95dc\u65bc\u79d1\u502b\u535a\u6cf0 \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31\"\u79d1\u502b\u535a\u6cf0\"\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002 Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23. \u53ef\u745e\u9054\u00ae\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=408410","og_locale":"zh_TW","og_type":"article","og_title":"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u6210\u90fd2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\"\u79d1\u502b\u535a\u6cf0\"\u6216\"\u516c\u53f8\"\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002 \u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002 OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002 \u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684PFS\u7372\u76ca\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)\u3002 \u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002 \u95dc\u65bcHR+\/HER2-\u4e73\u817a\u764c \u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002 \u95dc\u65bc\u79d1\u502b\u535a\u6cf0 \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31\"\u79d1\u502b\u535a\u6cf0\"\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002 Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23. \u53ef\u745e\u9054\u00ae\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=408410","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2026-02-06T09:00:00+00:00","og_image":[{"width":1706,"height":960,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408410"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7","datePublished":"2026-02-06T09:00:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408410"},"wordCount":153,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/logo_kelun_Biotech_Logo.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=408410","url":"https:\/\/pingtungtimes.com.tw\/?p=408410","name":"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/logo_kelun_Biotech_Logo.jpg","datePublished":"2026-02-06T09:00:00+00:00","description":"\u6210\u90fd2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\"\u79d1\u502b\u535a\u6cf0\"\u6216\"\u516c\u53f8\"\uff0c6990.HK)\u5ba3\u4f48\uff0c\u516c\u53f8\u7684TROP2 ADC\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT\uff0c\u4ea6\u7a31SKB264\/MK-2870)(\u4f73\u6cf0\u840a\u00ae)\u7684\u4e00\u9805\u65b0\u589e\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5df2\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u6279\u51c6\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684\u6fc0\u7d20\u53d7\u9ad4(HR)\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u6578\u53d7\u9ad42(HER2)\u9670\u6027(IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-)\u4e73\u817a\u764c\u6210\u4eba\u60a3\u8005\u3002\u6b64\u6b21\u7372\u6279\u7684\u81f3\u5c11\u7d93\u4e00\u7dda\u5316\u7642\u6cbb\u7642HR+\/HER2-\u4e73\u817a\u764c\uff0c\u662f\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5728\u4e2d\u570b\u4e0a\u5e02\u7684\u7b2c\u56db\u9805\u9069\u61c9\u75c7\u3002 \u672c\u6b21\u7372\u6279\u57fa\u65bcOptiTROP-Breast02 III\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u7a4d\u6975\u7d50\u679c\uff0c\u8a72\u7814\u7a76\u5df2\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703(ESMO)\u5927\u6703\u5165\u9078\u6700\u65b0\u7a81\u7834\u6027\u6458\u8981(LBA)\uff0c\u4e26\u4ee5\u53e3\u982d\u5831\u544a\u7684\u5f62\u5f0f\u767c\u4f48\u3002 OptiTROP-Breast02\u7814\u7a76\u8a55\u4f30\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u55ae\u85e5\u5c0d\u6bd4\u7814\u7a76\u8005\u9078\u64c7\u5316\u7642\u7528\u65bc\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u672c\u9805III\u671f\u7814\u7a76\u5165\u7d44\u60a3\u8005\u4e2d\uff0c95.7%\u7684\u60a3\u8005\u5165\u7d44\u6642\u5b58\u5728\u5167\u81df\u8f49\u79fb\uff0c75.9%\u7684\u60a3\u8005\u5b58\u5728\u809d\u8f49\u79fb; 52.9%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u8868\u9054\u70ba0(IHC 0)\uff0c47.1%\u7684\u60a3\u8005\u5165\u7d44\u6642HER2\u70ba\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-); \u6240\u6709\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904eCDK 4\/6\u6291\u5236\u5291\u548c\u7d2b\u6749\u70f7\u985e\u85e5\u7269\u6cbb\u7642\u3002\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff0c56.6%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u904e\u22652\u7dda\u5316\u7642\u65b9\u6848\u6cbb\u7642\u3002 \u7d50\u679c\u986f\u793a\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u76f2\u614b\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703(BIRC)\u8a55\u4f30\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f(PFS)\u76f8\u8f03\u65bc\u5316\u7642\u7d44\u986f\u793a\u51fa\u5177\u6709\u986f\u8457\u7d71\u8a08\u5b78\u610f\u7fa9\u548c\u81e8\u5e8a\u610f\u7fa9\u7684\u6539\u5584(8.3\u500b\u6708vs. 4.1\u500b\u6708\uff1bHR, 0.35\uff1b95% CI: 0.26-0.48\uff1bp<0.0001)\uff1b\u5728\u9810\u5148\u8a2d\u5b9a\u7684\u5404\u4e9e\u7d44\u4e2d\u5747\u89c0\u5bdf\u5230\u4e00\u81f4\u7684PFS\u7372\u76ca\uff0c\u5305\u62ecHER2\u8868\u9054\u70ba0\u53caHER2\u4f4e\u8868\u9054\u3001\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\u63a5\u53d7\u5316\u7642\u7dda\u6578\u3001\u57fa\u7dda\u6709\u7121\u5167\u81df\u8f49\u79fb\u3001\u57fa\u7dda\u809d\u8f49\u79fb\u3001\u65e2\u5f80CDK4\/6\u6291\u5236\u5291\u6cbb\u7642\u6642\u9577\u3002 BIRC\u8a55\u4f30\u7684PFS\u7d50\u679c\u986f\u793a\uff0c\u5728HER2\u8868\u9054\u70ba0\u548cHER2\u4f4e\u8868\u9054(IHC 1+\u6216IHC 2+\/ISH-)\u4e9e\u7d44\u4e2d\uff0c\u98a8\u96aa\u6bd4(HR)\u5206\u5225\u70ba0.39(95% CI\uff1a0.26-0.57)\u548c0.31(95% CI\uff1a0.20-0.48)\u3002\u540c\u6642\uff0c\u76f8\u8f03\u65bc\u5316\u7642\u7d44\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7d44\u986f\u793a\u51fa\u7e3d\u751f\u5b58\u671f(OS)\u7684\u7372\u76ca\u8da8\u52e2\u4ee5\u53ca\u5ba2\u89c0\u7de9\u89e3\u7387(ORR)\u7684\u660e\u986f\u63d0\u5347\uff0841.5% vs 24.1%)\u3002 \u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u806f\u5408\/\u4e0d\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297(\u53ef\u745e\u9054\u00ae)\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4f46\u672a\u63a5\u53d7\u904e\u5316\u7642\u7684HR+\/HER2-\u4e73\u817a\u764c\u60a3\u8005\u7684\u5168\u7403(NCT06312176)\u548c\u4e2d\u570b(NCT07071337)\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u5747\u5df2\u555f\u52d5\u3002 \u95dc\u65bcHR+\/HER2-\u4e73\u817a\u764c \u4e73\u817a\u764c\u662f\u56b4\u91cd\u5a01\u8105\u5168\u4e16\u754c\u5973\u6027\u5065\u5eb7\u7684\u6700\u5e38\u898b\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u30022022\u5e74\uff0c\u5168\u7403\u65b0\u767c\u4e73\u817a\u764c\u75c5\u4f8b\u7d04229.7\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u7d0466.6\u842c\u3002\u5176\u4e2d\uff0cHR+\/HER2-\u4e73\u817a\u764c\u662f\u6700\u5e38\u898b\u7684\u4e9e\u578b\uff0c\u7d04\u5360\u5168\u90e8\u4e73\u817a\u764c\u75c5\u4f8b\u768470%\uff0c\u4f46\u665a\u671f\u60a3\u8005\u9810\u5f8c\u8f03\u5dee\u3002\u8a72\u4e9e\u578b\u4e73\u817a\u764c\u901a\u5e38\u5c0d\u6fc0\u7d20\u6cbb\u7642\u654f\u611f\uff0c\u56e0\u6b64\uff0c\u5167\u5206\u6ccc\u6cbb\u7642\u806f\u5408CDK4\/6\u6291\u5236\u5291\u662f\u5176\u6a19\u6e96\u6cbb\u7642\u65b9\u6848\u3002\u7136\u800c\uff0c\u5c0d\u65bc\u5167\u5206\u6ccc\u6cbb\u7642\u5931\u6557\u7684HR+\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\uff0c\u5316\u7642\u65b9\u6848\u662f\u76ee\u524d\u81e8\u5e8a\u4e0a\u5ee3\u6cdb\u61c9\u7528\u7684\u65b9\u6848\uff0c\u4f46\u5176\u53d6\u5f97\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\u8f03\u4f4e(\u7d0414-22.9%)\uff0c\u4e14\u751f\u5b58\u7372\u76ca\u6709\u9650\uff0c\u4e2d\u4f4dPFS\u50c5\u70ba4.0-4.9\u500b\u6708\u5de6\u53f3\u3002 \u95dc\u65bc\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)(\u4f73\u6cf0\u840a\u00ae) \u4f5c\u70ba\u516c\u53f8\u7684\u6838\u5fc3\u7522\u54c1\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u4e00\u6b3e\u516c\u53f8\u64c1\u6709\u81ea\u4e3b\u667a\u6167\u8ca1\u7522\u6b0a\u7684\u65b0\u578bTROP2 ADC\uff0c\u91dd\u5c0d\u975e\u5c0f\u7d30\u80de\u80ba\u764c(NSCLC)\u3001\u4e73\u817a\u764c(BC)\u3001\u80c3\u764c(GC)\u3001\u5a66\u79d1\u816b\u7624\u7b49\u665a\u671f\u5be6\u9ad4\u7624\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u63a1\u7528\u65b0\u578b\u9023\u63a5\u5b50\u9032\u884c\u958b\u767c\uff0c\u5176\u901a\u904e\u5076\u806f\u4e00\u7a2e\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7684\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\u4f5c\u70ba\u6709\u6548\u8f09\u8377\uff0c\u85e5\u7269\u6297\u9ad4\u6bd4(DAR)\u9054\u52307.4\u3002\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u901a\u904e\u91cd\u7d44\u6297TROP2\u4eba\u6e90\u5316\u55ae\u514b\u9686\u6297\u9ad4\u7279\u7570\u6027\u8b58\u5225\u816b\u7624\u7d30\u80de\u8868\u9762\u7684TROP2\uff0c\u5176\u5f8c\u88ab\u816b\u7624\u7d30\u80de\u5167\u541e\u4f75\u65bc\u7d30\u80de\u5167\u91cb\u653e\u6709\u6548\u8f09\u8377KL610023\u3002KL610023\u4f5c\u70ba\u62d3\u64b2\u7570\u69cb\u9176I\u6291\u5236\u5291\uff0c\u53ef\u8a98\u5c0e\u816b\u7624\u7d30\u80deDNA\u640d\u50b7\uff0c\u9032\u800c\u5c0e\u81f4\u7d30\u80de\u9031\u671f\u963b\u6eef\u53ca\u7d30\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5176\u4ea6\u65bc\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u91cb\u653eKL610023\u3002\u9452\u65bcKL610023\u5177\u6709\u7d30\u80de\u819c\u6ef2\u900f\u6027\uff0c\u5176\u53ef\u5be6\u73fe\u65c1\u89c0\u8005\u6548\u61c9\uff0c\u5373\u6bba\u6b7b\u9130\u8fd1\u7684\u816b\u7624\u7d30\u80de\u3002 \u65bc2022\u5e745\u6708\uff0c\u516c\u53f8\u6388\u4e88\u9ed8\u6c99\u6771(\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u5546\u865f)\u5728\u5927\u4e2d\u83ef\u5340(\u5305\u62ec\u4e2d\u570b\u5167\u5730\u3001\u9999\u6e2f\u3001\u6fb3\u9580\u53ca\u81fa\u7063)\u4ee5\u5916\u7684\u6240\u6709\u5730\u5340\u958b\u767c\u3001\u4f7f\u7528\u3001\u88fd\u9020\u53ca\u5546\u696d\u5316\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7684\u7368\u5bb6\u6b0a\u5229\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u76844\u9805\u9069\u61c9\u75c7\u5df2\u65bc\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u5206\u5225\u7528\u65bc\uff1a\u7d93EGFR-TKI\u548c\u542b\u9251\u5316\u7642\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u904e2\u7a2e\u7cfb\u7d71\u6cbb\u7642\uff08\u5176\u4e2d\u81f3\u5c111\u7a2e\u6cbb\u7642\u91dd\u5c0d\u665a\u671f\u6216\u8f49\u79fb\u6027\u968e\u6bb5\uff09\u7684\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027TNBC\uff1b\u7d93EGFR-TKI\u6cbb\u7642\u5f8c\u9032\u5c55\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0NSCLC\uff1b\u65e2\u5f80\u63a5\u53d7\u904e\u5167\u5206\u6ccc\u6cbb\u7642\u4e14\u5728\u665a\u671f\u75be\u75c5\u968e\u6bb5\u63a5\u53d7\u904e\u81f3\u5c11\u4e00\u7dda\u5316\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u7684HR+\/HER2- (IHC 0\u3001IHC 1+\u6216IHC 2+\/ISH-) BC\uff1b\u5176\u4e2d\u524d2\u9805\u9069\u61c9\u75c7\u5df2\u7d93\u88ab\u7d0d\u5165\u91ab\u4fdd\u7bc4\u570d\uff0c\u5c07\u70ba\u66f4\u591a\u4e73\u817a\u764c\u548c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u5e36\u4f86\u81e8\u5e8a\u7372\u76ca\u3002\u6b64\u5916\uff0c\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u5df2\u7372NMPA\u6388\u4e886\u9805\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a(BTD)\u3002 \u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u662f\u5168\u7403\u9996\u500b\u5728\u80ba\u764c\u9069\u61c9\u75c7\u7372\u6279\u4e0a\u5e02\u7684TROP2 ADC\u85e5\u7269\u3002\u76ee\u524d\uff0c\u79d1\u502b\u535a\u6cf0\u5df2\u5728\u4e2d\u570b\u958b\u5c559\u9805\u8a3b\u518a\u6027\u81e8\u5e8a\u7814\u7a76\u3002\u9ed8\u6c99\u6771\u5df2\u4f48\u5c4016\u9805\u6b63\u5728\u9032\u884c\u7684\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u4f5c\u70ba\u55ae\u85e5\u7642\u6cd5\u6216\u806f\u5408\u5e15\u535a\u5229\u73e0\u55ae\u6297\u6216\u5176\u4ed6\u6297\u764c\u85e5\u7269\u7528\u65bc\u591a\u7a2e\u985e\u578b\u764c\u75c7\u7684\u5168\u7403\u6027III\u671f\u81e8\u5e8a\u7814\u7a76(\u9019\u4e9b\u7814\u7a76\u7531\u9ed8\u6c99\u6771\u7533\u8fa6\u4e26\u4e3b\u5c0e)\u3002 \u95dc\u65bc\u79d1\u502b\u535a\u6cf0 \u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(\u7c21\u7a31\"\u79d1\u502b\u535a\u6cf0\"\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6990.HK)\u662f\u79d1\u502b\u85e5\u696d\u63a7\u80a1\u5b50\u516c\u53f8\uff0c\u5c08\u6ce8\u4e8e\u5275\u65b0\u751f\u7269\u6280\u8853\u85e5\u7269\u53ca\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u7814\u767c\u3001\u751f\u7522\u3001\u5546\u696d\u5316\u53ca\u570b\u969b\u5408\u4f5c\u3002\u516c\u53f8\u570d\u7e5e\u5168\u7403\u548c\u4e2d\u570b\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u91cd\u9ede\u4f48\u5c40\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u4ee3\u8b1d\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\uff0c\u5efa\u8a2d\u570b\u969b\u5316\u85e5\u7269\u7814\u767c\u8207\u7522\u696d\u5316\u5e73\u81fa\uff0c\u81f4\u529b\u65bc\u6210\u70ba\u5728\u5275\u65b0\u85e5\u7269\u9818\u57df\u570b\u969b\u9818\u5148\u7684\u4f01\u696d\u3002\u516c\u53f8\u76ee\u524d\u64c1\u670930\u4f59\u500b\u91cd\u9ede\u5275\u65b0\u85e5\u9805\u76ee\uff0c\u5176\u4e2d4\u500b\u9805\u76ee\u5df2\u7372\u6279\u4e0a\u5e02\uff0c10\u9918\u500b\u5c08\u6848\u6b63\u8655\u65bc\u81e8\u5e8a\u968e\u6bb5\u3002\u516c\u53f8\u6210\u529f\u69cb\u5efa\u4e86\u4eab\u8b7d\u570b\u969b\u7684\u5c08\u6709ADC\u53ca\u65b0\u578b\u5076\u806f\u85e5\u7269\u5e73\u81faOptiDCTM\uff0c\u5df2\u67092\u500bADC\u9805\u76ee\u7372\u6279\u4e0a\u5e02\uff0c\u591a\u500bADC\u6216\u65b0\u578b\u5076\u806f\u85e5\u7269\u7522\u54c1\u8655\u65bc\u81e8\u5e8a\u6216\u81e8\u5e8a\u524d\u7814\u7a76\u968e\u6bb5\u3002 Fan Y, Li H, Wang H, et al. ESMO Congress 2025, LBA23. \u53ef\u745e\u9054\u00ae\uff08\u5e15\u535a\u5229\u73e0\u55ae\u6297\uff09\u70ba\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7f85\u5a01\u5e02\u9ed8\u514b\u516c\u53f8\u7684\u9644\u5c6c\u516c\u53f8Merck Sharp & Dohme LLC (\u9ed8\u6c99\u6771)\u7684\u6ce8\u518a\u5546\u6a19\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=408410"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/logo_kelun_Biotech_Logo.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/logo_kelun_Biotech_Logo.jpg","width":400,"height":116},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=408410#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u7834\u5c40HR+\/HER2-\u4e73\u817a\u764c\uff01\u8606\u5eb7\u6c99\u59a5\u73e0\u55ae\u6297(sac-TMT)\u7372\u6279\u7b2c\u56db\u9805\u9069\u61c9\u75c7"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/408410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=408410"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/408410\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/408411"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=408410"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=408410"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=408410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}