{"id":408275,"date":"2026-02-06T13:10:00","date_gmt":"2026-02-06T05:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=408275"},"modified":"2026-02-06T13:10:00","modified_gmt":"2026-02-06T05:10:00","slug":"%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e5%ae%a3%e4%bd%88%e4%b8%ad%e5%9c%8b%e5%9c%8b%e5%ae%b6%e8%97%a5%e5%93%81%e7%9b%a3%e7%9d%a3%e7%ae%a1%e7%90%86%e5%b1%80%e6%89%b9%e5%87%86%e7%b6%ad%e9%81%a9%e5%b9%b3","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=408275","title":{"rendered":"\u96f2\u9802\u65b0\u8000\u5ba3\u4f48\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7dad\u9069\u5e73\u00ae\u7528\u65bc\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb"},"content":{"rendered":"
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\u96f2\u9802\u65b0\u8000\u9996\u5e2d\u57f7\u884c\u5b98\u7f85\u6c38\u6176<\/b>\u8868\u793a: \u300c\u5728\u4e2d\u570b\uff0c\u4e2d\u91cd\u5ea6\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6578\u91cf\u9f90\u5927\uff0c\u9577\u671f\u4ee5\u4f86\u4ecd\u9762\u81e8\u986f\u8457\u7684\u672a\u6eff\u8db3\u91ab\u7642\u9700\u6c42\u3002\u7dad\u9069\u5e73\u00ae<\/sup>\u70ba\u6210\u4eba\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u63d0\u4f9b\u4e86\u4e00\u7a2e\u6709\u671b\u5be6\u73fe\u7121\u6fc0\u7d20\u7de9\u89e3\u7684\u53e3\u670d\u6cbb\u7642\u9078\u64c7\uff0c\u6bcf\u65e5\u4e00\u6b21\u7d66\u85e5\uff0c\u4e14\u5177\u6709\u826f\u597d\u7684\u7372\u76ca\u2013\u98a8\u96aa\u7279\u5fb5\u3002\u6b64\u6b21\u7dad\u9069\u5e73\u00ae<\/sup>\u5728\u4e2d\u570b\u7684\u7372\u6279\uff0c\u586b\u88dc\u4e86\u4e2d\u91cd\u5ea6\u6f70\u760d\u6027\u7d50\u8178\u708e\u6cbb\u7642\u9818\u57df\u7684\u91cd\u8981\u7a7a\u767d\uff0c\u4e26\u70ba\u4ee5\u6df1\u5ea6\u9ecf\u819c\u7652\u5408\u70ba\u76ee\u6a19\u7684\u5275\u65b0\u53e3\u670d\u6cbb\u7642\u63d0\u4f9b\u4e86\u65b0\u7684\u9078\u64c7\u3002\u516c\u53f8\u5c07\u52a0\u5feb\u63a8\u9032\u7dad\u9069\u5e73\u00ae<\/sup>\u7684\u5546\u696d\u5316\u9032\u7a0b\uff0c\u4e26\u7a4d\u6975\u63a8\u52d5\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff0c\u6301\u7e8c\u63d0\u5347\u5275\u65b0\u7642\u6cd5\u5728\u4e2d\u570b\u7684\u53ef\u53ca\u6027\u548c\u53ef\u8ca0\u64d4\u6027\uff0c\u8b93\u66f4\u591a\u60a3\u8005\u53d7\u76ca\u3002\u300d<\/p>\n

\u7dad\u9069\u5e73\u00ae<\/sup>\u7684\u81e8\u5e8a\u50f9\u503c\u5df2\u7372\u5f97\u591a\u9805\u570b\u969b\u6b0a\u5a01\u6307\u5357\u7684\u5145\u5206\u8a8d\u53ef\u3002\u8a72\u85e5\u7269\u88ab\u7d0d\u51652024\u5e74\u7f8e\u570b\u80c3\u8178\u75c5\u5b78\u5354\u6703\uff08AGA\uff09\u81e8\u5e8a\u5be6\u8e10\u6307\u5357\uff0c\u63a8\u85a6\u4f5c\u70ba\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u4e00\u7dda\u6cbb\u7642\uff1b\u4e26\u65bc2025\u5e746\u6708\u88ab\u7d0d\u5165\u300a2025 ACG \u81e8\u5e8a\u6307\u5357\uff1a\u6210\u4eba\u6f70\u760d\u6027\u7d50\u8178\u708e\u300b\uff0c\u7372\u5f37\u70c8\u63a8\u85a6\u7528\u65bc\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u8a98\u5c0e\u548c\u7dad\u6301\u6cbb\u7642\uff0c\u5145\u5206\u9ad4\u73fe\u4e86\u570b\u969b\u6b0a\u5a01\u5b78\u8853\u6a5f\u69cb\u5c0d\u5176\u7642\u6548\u8207\u5b89\u5168\u6027\u7684\u9ad8\u5ea6\u8a8d\u53ef\u3002<\/p>\n

\u7dad\u9069\u5e73\u00ae<\/sup>\u65bc2024\u5e74\u548c2025\u5e74\u88ab\u7d0d\u5165\u7cb5\u6e2f\u6fb3\u5927\u7063\u5340\u5167\u57309\u5e02\u81e8\u5e8a\u6025\u9700\u9032\u53e3\u6e2f\u6fb3\u85e5\u54c1\u91ab\u7642\u5668\u68b0\u76ee\u9304\uff08\u6587\u4ef6\u4e2d\u540d\u7a31\u70ba\u300c\u4f0a\u66f2\u83ab\u5fb7\u300d\uff09\uff0c\u5728\u5927\u7063\u5340\u7387\u5148\u5be6\u73fe\u81e8\u5e8a\u61c9\u7528\u3002\u76ee\u524d\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u5df2\u5728\u7f8e\u570b\u3001\u6b50\u76df\u4ee5\u53ca\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u3001\u4e2d\u570b\u6fb3\u9580\u3001\u65b0\u52a0\u5761\u7b49\u591a\u500b\u570b\u5bb6\u548c\u5730\u5340\u7372\u5f97\u65b0\u85e5\u4e0a\u5e02\u6279\u51c6\u30022025\u5e743\u6708\uff0c\u96f2\u9802\u65b0\u8000\u555f\u52d5\u7dad\u9069\u5e73\u00ae<\/sup>\u5609\u5584\u5de5\u5ee0\u5efa\u8a2d\u9805\u76ee\uff0c\u70ba\u672c\u5730\u5316\u751f\u7522\u53ca\u9577\u671f\u53ef\u53ca\u6027\u63d0\u4f9b\u6709\u529b\u652f\u6301\u3002<\/p>\n

\u95dc\u65bc\u7dad\u9069\u5e73\u00ae<\/sup>\uff08\u7cbe\u6c28\u9178\u827e\u66f2\u83ab\u5fb7\u7247, VELSIPITY\u00ae<\/sup>\uff09<\/b><\/p>\n

\u7dad\u9069\u5e73\u00ae<\/sup>\u662f\u4e00\u7a2e\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7684\u9ad8\u9078\u64c7\u6027\u9798\u6c28\u9187-1-\u78f7\u9178\uff08S1P\uff09\u53d7\u9ad4\u8abf\u7bc0\u5291\uff0c\u63a1\u7528\u512a\u5316\u7684\u85e5\u7406\u5b78\u8a2d\u8a08\uff0c\u8207S1P\u53d7\u9ad41\u30014\u548c5\u7d50\u5408\u3002\u7dad\u9069\u5e73\u00ae<\/sup>\u76ee\u524d\u5df2\u5728\u7f8e\u570b\u3001\u6b50\u76df\u3001\u52a0\u62ff\u5927\u3001\u65e5\u672c\u3001\u6fb3\u5927\u5229\u4e9e\u3001\u82f1\u570b\u3001\u745e\u58eb\u3001\u4ee5\u8272\u5217\u3001\u571f\u8033\u5176\u3001\u5370\u5ea6\u4ee5\u53ca\u4e2d\u570b\u6fb3\u9580\u3001\u65b0\u52a0\u5761\u3001\u4e2d\u570b\u9999\u6e2f\u548c\u4e2d\u570b\u5927\u9678\u7372\u5f97\u65b0\u85e5\u4e0a\u5e02\u6279\u51c6\u3002<\/p>\n

\u95dc\u65bc\u4e9e\u6d32\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC<\/b> \u7814\u7a76\uff08ES101002\uff09<\/b><\/p>\n

ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u662f\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u53f0\u7063\u548c\u97d3\u570b\uff09\u958b\u5c55\u7684\u7dad\u9069\u5e73\u00ae<\/sup>\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167III\u671f\u7814\u7a76\uff0c\u4ea6\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6UC\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u61c9\u7b54\u4e0d\u5145\u5206\u3001\u4e0d\u61c9\u7b54\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027UC\u60a3\u8005\u9032\u5165\u8a98\u5c0e\u671f\uff0c\u4e14\u4ee52:1 \u96a8\u6a5f\u5206\u7d44\u5206\u5225\u63a5\u53d7\u7dad\u9069\u5e73\u00ae<\/sup>\u6216\u5b89\u6170\u5291\u6cbb\u764212\u5468\u3002\u5b8c\u621012\u5468\u8a98\u5c0e\u6cbb\u7642\u4e26\u9054\u5230\u81e8\u5e8a\u61c9\u7b54\u7684\u60a3\u8005\u9032\u5165\u7dad\u6301\u671f\uff0c\u518d\u6b21\u4ee51:1 \u96a8\u6a5f\u5206\u7d44\u63a5\u53d7\u70ba\u671f40\u5468\u7dad\u9069\u5e73\u00ae<\/sup>\u6216\u5b89\u6170\u5291\u7684\u6cbb\u7642\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u5206\u5225\u70ba\u60a3\u8005\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\u548c\u7dad\u6301\u671f\u7b2c40\u5468\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u6bd4\u4f8b\u3002\u7814\u7a76\u7684\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u5247\u70ba\u60a3\u8005\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\u548c\u7dad\u6301\u671f\u7b2c40\u5468\u9054\u5230\u5167\u93e1\u6539\u5584\u548c\u81e8\u5e8a\u61c9\u7b54\u7684\u6bd4\u4f8b\u3002<\/p>\n

\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u572812\u5468\u8a98\u5c0e\u53ca40\u5468\u7dad\u6301\u6cbb\u7642\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u6cbb\u7642\u7d44\u5728\u6240\u6709\u4e3b\u8981\u548c\u6b21\u8981\u7642\u6548\u7d42\u9ede\u4e0a\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u8207\u81e8\u5e8a\u610f\u7fa9\u3002<\/p>\n

\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u65b9\u9762\uff0c\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u7d44\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba25.0%\uff0c\u5b89\u6170\u5291\u7d445.4%\uff1b\u8abf\u6574\u5f8c\u5dee\u503c\u70ba20.4%\uff0c95% CI 13.4\u201327.4\uff0cp<0.0001\u3002\u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u7d44\u81e8\u5e8a\u7de9\u89e3\u7387\u70ba48.1%\uff0c\u5b89\u6170\u5291\u7d44\u70ba12.5%\uff1b\u8abf\u6574\u5dee\u503c35.9%\uff0c95% CI 22.5\u201349.2\uff0cp<0.0001\u3002<\/p>\n

\u6b21\u8981\u7642\u6548\u7d42\u9ede\u65b9\u9762\uff0c\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u7d44\u5167\u93e1\u6539\u5584\u7387\u70ba37.3%\uff0c\u5b89\u6170\u5291\u7d44\u70ba9.8%\uff1b\u8abf\u6574\u5f8c\u5dee\u503c28.6%\uff0c95% CI 20.5\u201336.7\uff0cp<0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u7387\u65b9\u9762\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u7d44\u70ba58.3%\uff0c\u5b89\u6170\u5291\u7d4427.7%\uff1b\u8abf\u6574\u5f8c\u5dee\u503c32.0%\uff0c95% CI 21.8\u201342.2\uff0cp<0.0001\u3002\u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u7d44\u5167\u93e1\u6539\u5584\u7387\u70ba61.0%\uff0c\u5b89\u6170\u5291\u7d44\u70ba15.0%\uff1b\u8abf\u6574\u5f8c\u5dee\u503c46.6%\uff0c95% CI 33.2\u201360.1\uff0cp<0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u7387\u65b9\u9762\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\u7d44\u70ba79.2%\uff0c\u5b89\u6170\u5291\u7d44\u70ba35.0%\uff1b\u8abf\u6574\u5f8c\u5dee\u503c45.6%\uff0c95% CI 31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae<\/sup>\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 [\u6392\u9664\u6613\u8106] \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae<\/sup>\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002<\/p>\n

\u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09<\/b><\/p>\n

ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76[4]<\/sup>\u3002<\/p>\n

ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002<\/p>\n

ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 12\u4e2d\uff0c25.0%\u63a5\u53d7\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c15%\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u8abf\u6574\u5f8c\u5dee\u503c9.7%\uff0cP=0.026\uff09\u3002\u7b2c12\u5468\u6642\u9054\u5230\u4e86\u8a66\u9a57\u7684\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u3002<\/p>\n

\u5728ELEVATE UC 12\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09 \u7d44\u548c\u5b89\u6170\u5291\u6cbb\u7642\u7d44\u767c\u751f\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\uff0c\u800c\u5728ELEVATE UC 52\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u7684\u9019\u4e00\u6bd4\u4f8b\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0c\u4f46\u5169\u9805\u8a66\u9a57\u4e2d\u5404\u6cbb\u7642\u7d44\u4e4b\u9593\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u5728\u5169\u9805\u8a66\u9a57\u4e2d\uff0c\u622a\u81f3\u7b2c52\u5468\uff0c\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u6cbb\u7642\u7d44\u4e2d\u767c\u751f\u7387\u22653%\u4e14\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u7684\u6700\u5e38\u898b\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u982d\u75db\u3001UC\u52a0\u91cd\u3001COVID-19\u611f\u67d3\u3001\u982d\u6688\u3001\u767c\u71b1\u3001\u95dc\u7bc0\u75db\u3001\u8179\u75db\u548c\u5641\u5fc3\u3002\u6c92\u6709\u5831\u544a\u5fc3\u52d5\u904e\u7de9\u6216\u623f\u5ba4\u963b\u6eef\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u8a66\u9a57\u6578\u64da\u8868\u660e\uff0c\u555f\u52d5\u7dad\u9069\u5e73\u00ae<\/sup>\uff08VELSIPITY\u00ae<\/sup>\uff09\u6cbb\u7642\u4e0d\u9700\u8981\u8907\u96dc\u7684\u6ef4\u5b9a\u65b9\u6848\u3002<\/p>\n

\u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/p>\n

[1] <\/sup>K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0.
[2]<\/sup> Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0
[3] <\/sup>Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727.
[4]<\/sup> Sandborn WJ, et al. Lancet. 2023 Apr 8;401(10383):1159-1171.<\/p>\n

\u95dc\u65bc\u96f2\u9802\u65b0\u8000<\/b><\/p>\n

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\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n

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31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002 \u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09 ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76\u3002 ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002 ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 12\u4e2d\uff0c25.0%\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c15%\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u8abf\u6574\u5f8c\u5dee\u503c9.7%\uff0cP=0.026\uff09\u3002\u7b2c12\u5468\u6642\u9054\u5230\u4e86\u8a66\u9a57\u7684\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u3002 \u5728ELEVATE UC 12\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09 \u7d44\u548c\u5b89\u6170\u5291\u6cbb\u7642\u7d44\u767c\u751f\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\uff0c\u800c\u5728ELEVATE UC 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\u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002 \u53c3\u8003\u6587\u737b\uff1a K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0. Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0 Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727. Sandborn WJ, et al. Lancet. 2023 Apr 8;401(10383):1159-1171. \u95dc\u65bc\u96f2\u9802\u65b0\u8000 \u96f2\u9802\u65b0\u8000\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u5168\u7403\u5e02\u5834\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u96f2\u9802\u65b0\u8000\u7684\u7ba1\u7406\u5718\u968a\u5728\u4e2d\u570b\u53ca\u5168\u7403\u9818\u5148\u88fd\u85e5\u4f01\u696d\u64c1\u6709\u6df1\u539a\u7684\u5c08\u9577\u548c\u8c50\u5bcc\u7684\u7d93\u9a57\u3002\u516c\u53f8\u5728\u6d59\u6c5f\u5609\u5584\u64c1\u6709\u5177\u5099\u5546\u696d\u5316\u898f\u6a21\u7684\u5168\u7403\u751f\u7522\u57fa\u5730\uff0c\u4e26\u56b4\u683c\u6309\u7167\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684 GMP 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31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002 \u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09 ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76\u3002 ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002 ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 12\u4e2d\uff0c25.0%\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c15%\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u8abf\u6574\u5f8c\u5dee\u503c9.7%\uff0cP=0.026\uff09\u3002\u7b2c12\u5468\u6642\u9054\u5230\u4e86\u8a66\u9a57\u7684\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u3002 \u5728ELEVATE UC 12\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09 \u7d44\u548c\u5b89\u6170\u5291\u6cbb\u7642\u7d44\u767c\u751f\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\uff0c\u800c\u5728ELEVATE UC 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\u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002 \u53c3\u8003\u6587\u737b\uff1a K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0. Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0 Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727. Sandborn WJ, et al. 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UC\u7814\u7a76\uff08ES101002\uff09\u662f\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u53f0\u7063\u548c\u97d3\u570b\uff09\u958b\u5c55\u7684\u7dad\u9069\u5e73\u00ae\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167III\u671f\u7814\u7a76\uff0c\u4ea6\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6UC\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u61c9\u7b54\u4e0d\u5145\u5206\u3001\u4e0d\u61c9\u7b54\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027UC\u60a3\u8005\u9032\u5165\u8a98\u5c0e\u671f\uff0c\u4e14\u4ee52:1 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31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002 \u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09 ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76\u3002 ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002 ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 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52\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u9019\u4e00\u6bd4\u4f8b\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0c\u4f46\u5169\u9805\u8a66\u9a57\u4e2d\u5404\u6cbb\u7642\u7d44\u4e4b\u9593\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u5728\u5169\u9805\u8a66\u9a57\u4e2d\uff0c\u622a\u81f3\u7b2c52\u5468\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7d44\u4e2d\u767c\u751f\u7387\u22653%\u4e14\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u7684\u6700\u5e38\u898b\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u982d\u75db\u3001UC\u52a0\u91cd\u3001COVID-19\u611f\u67d3\u3001\u982d\u6688\u3001\u767c\u71b1\u3001\u95dc\u7bc0\u75db\u3001\u8179\u75db\u548c\u5641\u5fc3\u3002\u6c92\u6709\u5831\u544a\u5fc3\u52d5\u904e\u7de9\u6216\u623f\u5ba4\u963b\u6eef\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u8a66\u9a57\u6578\u64da\u8868\u660e\uff0c\u555f\u52d5\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u4e0d\u9700\u8981\u8907\u96dc\u7684\u6ef4\u5b9a\u65b9\u6848\u3002 \u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002 \u53c3\u8003\u6587\u737b\uff1a K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0. Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0 Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727. Sandborn WJ, et al. 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31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002 \u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09 ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76\u3002 ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002 ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 12\u4e2d\uff0c25.0%\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c15%\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u8abf\u6574\u5f8c\u5dee\u503c9.7%\uff0cP=0.026\uff09\u3002\u7b2c12\u5468\u6642\u9054\u5230\u4e86\u8a66\u9a57\u7684\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u3002 \u5728ELEVATE UC 12\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09 \u7d44\u548c\u5b89\u6170\u5291\u6cbb\u7642\u7d44\u767c\u751f\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\uff0c\u800c\u5728ELEVATE UC 52\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u9019\u4e00\u6bd4\u4f8b\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\uff0c\u4f46\u5169\u9805\u8a66\u9a57\u4e2d\u5404\u6cbb\u7642\u7d44\u4e4b\u9593\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\u3002\u5728\u5169\u9805\u8a66\u9a57\u4e2d\uff0c\u622a\u81f3\u7b2c52\u5468\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7d44\u4e2d\u767c\u751f\u7387\u22653%\u4e14\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u7684\u6700\u5e38\u898b\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\u70ba\u982d\u75db\u3001UC\u52a0\u91cd\u3001COVID-19\u611f\u67d3\u3001\u982d\u6688\u3001\u767c\u71b1\u3001\u95dc\u7bc0\u75db\u3001\u8179\u75db\u548c\u5641\u5fc3\u3002\u6c92\u6709\u5831\u544a\u5fc3\u52d5\u904e\u7de9\u6216\u623f\u5ba4\u963b\u6eef\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002\u8a66\u9a57\u6578\u64da\u8868\u660e\uff0c\u555f\u52d5\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u4e0d\u9700\u8981\u8907\u96dc\u7684\u6ef4\u5b9a\u65b9\u6848\u3002 \u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002 \u53c3\u8003\u6587\u737b\uff1a K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0. Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0 Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727. Sandborn WJ, et al. Lancet. 2023 Apr 8;401(10383):1159-1171. \u95dc\u65bc\u96f2\u9802\u65b0\u8000 \u96f2\u9802\u65b0\u8000\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u6eff\u8db3\u5168\u7403\u5e02\u5834\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\u3002\u96f2\u9802\u65b0\u8000\u7684\u7ba1\u7406\u5718\u968a\u5728\u4e2d\u570b\u53ca\u5168\u7403\u9818\u5148\u88fd\u85e5\u4f01\u696d\u64c1\u6709\u6df1\u539a\u7684\u5c08\u9577\u548c\u8c50\u5bcc\u7684\u7d93\u9a57\u3002\u516c\u53f8\u5728\u6d59\u6c5f\u5609\u5584\u64c1\u6709\u5177\u5099\u5546\u696d\u5316\u898f\u6a21\u7684\u5168\u7403\u751f\u7522\u57fa\u5730\uff0c\u4e26\u56b4\u683c\u6309\u7167\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u6b50\u6d32\u85e5\u54c1\u7ba1\u7406\u5c40\uff08EMA\uff09\u7684 GMP 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31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002 \u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09 ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76\u3002 ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002 ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 12\u4e2d\uff0c25.0%\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c15%\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u8abf\u6574\u5f8c\u5dee\u503c9.7%\uff0cP=0.026\uff09\u3002\u7b2c12\u5468\u6642\u9054\u5230\u4e86\u8a66\u9a57\u7684\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u3002 \u5728ELEVATE UC 12\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09 \u7d44\u548c\u5b89\u6170\u5291\u6cbb\u7642\u7d44\u767c\u751f\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\uff0c\u800c\u5728ELEVATE UC 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\u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002 \u53c3\u8003\u6587\u737b\uff1a K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0. Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0 Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727. Sandborn WJ, et al. 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31.9\u201359.3\uff0cp<0.0001\u3002\u5176\u4ed6\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\uff0c\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p<0.0001\uff09\u7684\u6539\u5584\u3002\u7dad\u9069\u5e73\u00ae\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.80%\uff08p\uff1c0.0001\uff09\u3002\u6b64\u5916\uff0cENLIGHT UC\u7814\u7a76\u4e5f\u8b49\u5be6\u4e86\u7dad\u9069\u5e73\u00ae\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u8207\u5df2\u77e5\u7279\u5fb5\u548c\u5168\u7403\u2162\u671f\u4e00\u81f4\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u4fe1\u865f\u4e8b\u4ef6\u3002 \u95dc\u65bcELEVATE UC III\u671f\u8a3b\u518a\u7814\u7a76\uff08ELEVATE UC 52\u548cELEVATE UC 12\uff09 ELEVATE UC \u2162\u671f\u81e8\u5e8a\u8a66\u9a57\u5305\u62ecELEVATE UC 52\u548cELEVATE UC 12\u7814\u7a76\u3002 ELEVATE UC 52\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5305\u62ec12\u5468\u7684\u8a98\u5c0e\u671f\u548c40\u5468\u7684\u7dad\u6301\u671f\u3002\u5f9e\u7b2c12\u5468\u958b\u59cb\uff0c\u6240\u6709\u60a3\u8005\u5747\u53ef\u7e7c\u7e8c\u63a5\u53d7\u5176\u96a8\u6a5f\u6cbb\u7642\uff1b\u8207\u57fa\u7dda\u6642\u76f8\u6bd4\uff0c\u75be\u75c5\u7121\u6539\u5584\u6216\u75be\u75c5\u60e1\u5316\u7684\u60a3\u8005\u53ef\u4ee5\u505c\u6b62\u6cbb\u7642\uff0c\u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u53ef\u5165\u7d44\u958b\u653e\u64f4\u5c55\u7814\u7a76\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u548c52\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\u6027\u3002\u4e3b\u8981\u7d42\u9ede\u662f\u81e8\u5e8a\u7de9\u89e3\uff0c\u5b9a\u7fa9\u70ba\u57fa\u65bc\u6885\u5967\u8a55\u5206\u4e2d3\u500b\u5b50\u9805\u7684\u6539\u5584\uff0c\u5305\u62ec\u6392\u4fbf\u6b21\u6578\u55ae\u9805\u8a55\u5206\u70ba0\uff08\u6216\u70ba1\u4e14\u8f03\u57fa\u7dda\u964d\u4f4e\u81f3\u5c11\u70ba1\u5206\uff0c\u4fbf\u8840\u55ae\u9805\u8a55\u5206\u70ba0\uff0c\u5167\u93e1\u55ae\u9805\u8a55\u5206<=1 (\u6392\u9664\u6613\u8106\uff09\u3002\u5728ELEVATE UC 52\u4e2d\uff0c\u7b2c12\u5468\u6642\uff0c\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u7684\u81e8\u5e8a\u7de9\u89e3\u7387\u5206\u5225\u70ba27.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c19.8%\uff0cP\u02c20.0001\uff09\uff0c\u7b2c52\u5468\u6642\u5206\u5225\u70ba32.0%\u548c7.0%\uff08\u8abf\u6574\u5f8c\u5dee\u503c25.4%\uff0cP\u02c20.0001\uff09\u3002\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08\u5305\u62ec\u7b2c12\u5468\u548c\u7b2c\u00a052\u00a0\u5468\u6642\u7684\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u60c5\u6cc1\u4ee5\u53ca\u7b2c52\u5468\u6642\u7684\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6301\u7e8c\u81e8\u5e8a\u7de9\u89e3\uff09\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u6539\u5584\u3002 ELEVATE UC 12\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u670d\u75282mg\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u572812\u5468\u6cbb\u7642\u5f8c\u7684\u5b89\u5168\u6027\u548c\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u7642\u6548\uff0c\u8a55\u4f30\u57fa\u65bc3\u500b\u5b50\u9805\u7684\u6539\u826f\u6885\u5967\u8a55\u5206\u3002\u5728ELEVATE UC 12\u4e2d\uff0c25.0%\u63a5\u53d7\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09\u6cbb\u7642\u7684\u60a3\u8005\u548c15%\u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff08\u8abf\u6574\u5f8c\u5dee\u503c9.7%\uff0cP=0.026\uff09\u3002\u7b2c12\u5468\u6642\u9054\u5230\u4e86\u8a66\u9a57\u7684\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0c\u5305\u62ec\u5167\u93e1\u6539\u5584\u548c\u9ecf\u819c\u7652\u5408\u3002 \u5728ELEVATE UC 12\u4e2d\uff0c\u7dad\u9069\u5e73\u00ae\uff08VELSIPITY\u00ae\uff09 \u7d44\u548c\u5b89\u6170\u5291\u6cbb\u7642\u7d44\u767c\u751f\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u76f8\u4f3c\uff0c\u800c\u5728ELEVATE UC 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\u5728ELEVATE UC 52\u548cELEVATE UC 12\u4e2d\uff0c\u5206\u5225\u6709\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u65e2\u5f80\u5f9e\u672a\u63a5\u53d7\u904e\u751f\u7269\u5236\u5291\u6216JAK\u6291\u5236\u5291\u6cbb\u7642\u3002 \u53c3\u8003\u6587\u737b\uff1a K. Wu, et al. Lancet Gastroenterol Hepatol. 2025 Sep 30:S2468-1253(25)00198-0. Shao B, et al. Front Public Health. 2022 Oct 25;10:1032679.\u00a0\u00a0\u00a0 Kaplan GG. Nat Rev Gastroenterol Hepatol. 2015;12(12):720-727. Sandborn WJ, et al. 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