{"id":408221,"date":"2026-02-06T10:04:00","date_gmt":"2026-02-06T02:04:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=408221"},"modified":"2026-02-06T10:04:00","modified_gmt":"2026-02-06T02:04:00","slug":"%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5btk%e9%99%8d%e8%a7%a3%e5%8a%91apg-3288%e6%96%b0%e8%97%a5%e8%87%a8%e5%ba%8a%e7%94%b3%e8%ab%8b%ef%bc%88ind%ef%bc%89%e7%8d%b2cde%e8%a8%b1%e5%8f%af%ef%bc%8c%e5%85%a8","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=408221","title":{"rendered":"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2026\u5e742\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002<\/p>\n

\n<\/p><\/div>\n

\u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002<\/p>\n

BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49[1]<\/span><\/sup>\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42[2]<\/span><\/sup>\u3002<\/p>\n

APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848[3]<\/span><\/sup>\u3002<\/p>\n

\u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae<\/sup>\u3001\u5229\u751f\u59a5\u00ae<\/sup>\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a<\/b>\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d<\/p>\n

\u53c3\u8003\u6587\u737b\uff1a<\/p>\n

[1]. Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton’s tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).
[2]. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.
[3]. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596.<\/p>\n

\u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/b><\/p>\n

\u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002<\/p>\n

\u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae<\/sup>\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae<\/sup>\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002<\/p>\n

\u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae<\/sup>\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002<\/p>\n

\u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607…<\/p>\n","protected":false},"author":16,"featured_media":408222,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-408221","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002 BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42\u3002 APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848\u3002 \u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a . Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton's tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=408221\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002 BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42\u3002 APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848\u3002 \u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a . Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton's tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=408221\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-06T02:04:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1706\" \/>\n\t<meta property=\"og:image:height\" content=\"960\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f\",\"datePublished\":\"2026-02-06T02:04:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221\"},\"wordCount\":156,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/Ascentage_APAC_Logo.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221\",\"name\":\"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/Ascentage_APAC_Logo.jpg\",\"datePublished\":\"2026-02-06T02:04:00+00:00\",\"description\":\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e742\u67086\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002 BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42\u3002 APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848\u3002 \u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a . Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton's tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\\\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\\\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u00a0\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/Ascentage_APAC_Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/Ascentage_APAC_Logo.jpg\",\"width\":400,\"height\":150},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=408221#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002 BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42\u3002 APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848\u3002 \u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a . Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton's tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=408221","og_locale":"zh_TW","og_type":"article","og_title":"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002 BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42\u3002 APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848\u3002 \u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a . Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton's tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=408221","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2026-02-06T02:04:00+00:00","og_image":[{"width":1706,"height":960,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408221"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f","datePublished":"2026-02-06T02:04:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408221"},"wordCount":156,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/Ascentage_APAC_Logo.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=408221","url":"https:\/\/pingtungtimes.com.tw\/?p=408221","name":"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/Ascentage_APAC_Logo.jpg","datePublished":"2026-02-06T02:04:00+00:00","description":"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2026\u5e742\u67086\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u539f\u5275\u65b0\u4e00\u4ee3\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u9776\u5411\u86cb\u767d\u964d\u89e3\u5291APG-3288\u7684\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u65e5\u524d\u5df2\u7372\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u8a31\u53ef\uff0c\u64ec\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u3002\u6b64\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u7372\u7f8e\u570bFDA\u8a31\u53ef\u958b\u5c55\u81e8\u5e8a\u8a66\u9a57\u3002\u6b64\u6b21\u570b\u5167\u81e8\u5e8a\u7372\u6279\uff0c\u6a19\u5fd7\u8457APG-3288\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u958b\u767c\u9081\u5165\u5168\u65b0\u968e\u6bb5\uff0c\u4e5f\u5f70\u986f\u4e86\u4e9e\u76db\u91ab\u85e5\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u5168\u7403\u7814\u767c\u5be6\u529b\u3002 \u8a72\u7814\u7a76\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30APG-3288\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\u8840\u6db2\u7cfb\u7d71\u60e1\u6027\u816b\u7624\u60a3\u8005\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5f81\u53ca\u521d\u6b65\u7642\u6548\u3002 BTK\u662fB\u7d30\u80de\u53d7\u9ad4\uff08BCR\uff09\u4fe1\u865f\u901a\u8def\u4e2d\u7684\u95dc\u9375\u6fc0\u9176\uff0c\u5728B\u7d30\u80de\u7684\u6d3b\u5316\u3001\u589e\u6b96\u548c\u5b58\u6d3b\u4e2d\u767c\u63ee\u6838\u5fc3\u4f5c\u7528\u3002BTK\u7570\u5e38\u6fc0\u6d3b\u88ab\u8a8d\u70ba\u8207\u591a\u7a2eB\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u5305\u62ec\u591a\u7a2eB\u7d30\u80de\u6dcb\u5df4\u7624\uff08\u5f4c\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u3001\u6ffe\u6ce1\u6027\u6dcb\u5df4\u7624\u7b49\uff09\u3001\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u3001\u4ee5\u53ca\u83ef\u6c0f\u5de8\u7403\u86cb\u767d\u8840\u75c7\uff08WM\uff09\u7b49\u3002\u5728B\u7d30\u80de\u60e1\u6027\u816b\u7624\u7684\u6cbb\u7642\u4e2d\uff0c\u76e1\u7ba1BTK\u6291\u5236\u5291\u5df2\u986f\u8457\u6539\u5584\u60a3\u8005\u9810\u5f8c\uff0c\u4f46\u96a8\u8457\u6cbb\u7642\u6642\u9593\u5ef6\u9577\uff0c\u7531BTK\u7a81\u8b8a\u6216\u4fe1\u865f\u901a\u8def\u91cd\u5851\u5c0e\u81f4\u7684\u8010\u85e5\u554f\u984c\u9010\u6f38\u986f\u73fe\uff0c\u81e8\u5e8a\u4e0a\u4ecd\u5b58\u5728\u5c0d\u5168\u65b0\u4f5c\u7528\u6a5f\u5236\u85e5\u7269\u7684\u8feb\u5207\u9700\u6c42\u3002 APG-3288\u662f\u4e9e\u76db\u91ab\u85e5\u57fa\u65bc\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u9ad4\uff08PROTAC\uff09\u6280\u8853\u5e73\u53f0\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9ad8\u6548\u3001\u9ad8\u9078\u64c7\u6027BTK\u964d\u89e3\u5291\uff0c\u901a\u904e\u5f62\u6210\u4e09\u5143\u5fa9\u5408\u7269BTK-PROTAC-Cereblon E3\u6cdb\u7d20\u9023\u63a5\u9176\uff0c\u96a8\u4e4b\u7d93\u86cb\u767d\u9176\u9ad4\u964d\u89e3BTK\u3002\u8207\u50b3\u7d71BTK\u6291\u5236\u5291\u4e0d\u540c\uff0cAPG-3288\u65e8\u5728\u901a\u904e\u964d\u89e3\u800c\u975e\u6291\u5236\u7684\u5275\u65b0\u4f5c\u7528\u6a5f\u5236\uff0c\u53ef\u8a98\u5c0e\u91ce\u751f\u578b\u53ca\u591a\u7a2e\u5c0d\u73fe\u6709BTK\u6291\u5236\u5291\u8010\u85e5\u7684\u7a81\u8b8a\u578bBTK\u767c\u751f\u5feb\u901f\u3001\u5f37\u6548\u3001\u9ad8\u9078\u64c7\u6027\u548c\u6301\u7e8c\u6027\u7684\u964d\u89e3\uff0c\u5728\u6e90\u982d\u963b\u65b7BCR\u2013BTK\u4fe1\u865f\u901a\u8def\uff0c\u5f9e\u800c\u514b\u670d\u50b3\u7d71BTK\u6291\u5236\u5291\u8010\u85e5\u96e3\u984c\uff0c\u70baBTK\u9776\u5411\u6cbb\u7642\u63d0\u4f9b\u5dee\u7570\u5316\u7684\u5168\u65b0\u89e3\u6c7a\u65b9\u6848\u3002 \u4f5c\u70ba\u805a\u7126\u816b\u7624\u9818\u57df\u5275\u65b0\u85e5\u7814\u767c\u7684\u4f01\u696d\uff0c\u4e9e\u76db\u91ab\u85e5\u6df1\u8015\u8840\u6db2\u816b\u7624\u6cbb\u7642\u9818\u57df\u591a\u5e74\uff0c\u5df2\u64c1\u6709\u8010\u7acb\u514b\u00ae\u3001\u5229\u751f\u59a5\u00ae\u5169\u6b3e\u7372\u6279\u4e0a\u5e02\u76841\u985e\u5275\u65b0\u85e5\u3002\u6b64\u6b21APG-3288\u5728\u4e2d\u570b\u7372\u81e8\u5e8a\u8a66\u9a57\u8a31\u53ef\uff0c\u5c07\u9032\u4e00\u6b65\u8c50\u5bcc\u516c\u53f8\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e5f\u70ba\u63a2\u7d22\u5176\u8207\u516c\u53f8\u73fe\u6709\u6838\u5fc3\u54c1\u7a2e\u7684\u806f\u5408\u6cbb\u7642\u6f5b\u529b\u5960\u5b9a\u57fa\u790e\u3002 \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300cAPG-3288\u63a5\u9023\u7372FDA\u548cCDE\u7684\u81e8\u5e8a\u8a31\u53ef\uff0c\u662f\u516c\u53f8\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u9818\u57df\u7684\u91cd\u8981\u88e1\u7a0b\u7891\uff0c\u4e5f\u662f\u516c\u53f8\u300e\u5168\u7403\u5275\u65b0\u300f\u6230\u7565\u7684\u53c8\u4e00\u91cd\u8981\u6210\u679c\u3002\u8840\u6db2\u816b\u7624\u9818\u57df\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\uff0c\u5c24\u5176\u662f\u8010\u85e5\u5f8c\u7684\u6cbb\u7642\u9078\u64c7\u5331\u4e4f\u3002\u6211\u5011\u5c07\u52a0\u901f\u63a8\u9032APG-3288\u7684\u5168\u7403\u81e8\u5e8a\u958b\u767c\u9032\u7a0b\uff0c\u540c\u6642\u7a4d\u6975\u63a2\u7d22\u5176\u806f\u5408\u6cbb\u7642\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u5e0c\u671b\u9019\u6b3e\u5275\u65b0\u85e5\u7269\u80fd\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u3002\u300d \u53c3\u8003\u6587\u737b\uff1a . Pal Singh, S., F. Dammeijer, and R.W. Hendriks, Role of Bruton's tyrosine kinase in B cells and malignancies. Molecular Cancer, 2018. 17(1).. Wang, E., et al., Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. New England Journal of Medicine, 2022. 386(8): p. 735-743.. Zhang, D., et al., NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts. Blood, 2023. 141(13): p. 1584-1596. \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\uff1b\u86cb\u767d\u964d\u89e3\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u00a0","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=408221"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/Ascentage_APAC_Logo.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2026\/02\/Ascentage_APAC_Logo.jpg","width":400,"height":150},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=408221#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u4e9e\u76db\u91ab\u85e5BTK\u964d\u89e3\u5291APG-3288\u65b0\u85e5\u81e8\u5e8a\u7533\u8acb\uff08IND\uff09\u7372CDE\u8a31\u53ef\uff0c\u5168\u7403\u81e8\u5e8a\u958b\u767c\u518d\u63d0\u901f"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/408221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=408221"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/408221\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/408222"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=408221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=408221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=408221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}