{"id":405894,"date":"2026-01-29T21:05:00","date_gmt":"2026-01-29T13:05:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=405894"},"modified":"2026-01-29T21:05:00","modified_gmt":"2026-01-29T13:05:00","slug":"skyhawk-therapeutics-%e5%85%ac%e4%bd%88%e5%85%b6%e7%94%a8%e6%96%bc%e6%b2%bb%e7%99%82-huntington-%e7%96%be%e7%97%85%e7%9a%84%e8%97%a5%e7%89%a9-sky-0515-%e6%96%bc%e7%ac%ac-1-%e6%9c%9f%e8%87%a8%e5%ba%8a","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=405894","title":{"rendered":"Skyhawk Therapeutics \u516c\u4f48\u5176\u7528\u65bc\u6cbb\u7642 Huntington \u75be\u75c5\u7684\u85e5\u7269 SKY-0515 \u65bc\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d \u53d7\u8a66\u60a3\u8005\u7684\u4e5d\u500b\u6708\u4e2d\u671f\u7d50\u679c\u3002"},"content":{"rendered":"
\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e5d\u500b\u6708\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u8a55\u5206\u8f03\u57fa\u7dda\u5e73\u5747\u6539\u5584 +0.64 \u5206\u3002<\/b>\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6839\u64da\u50be\u5411\u8a55\u5206\u52a0\u6b0a\uff0c\u6709\u75c7\u72c0\u60a3\u8005\u7684\u4e5d\u500b\u6708\u81ea\u7136\u60e1\u5316 cUHDRS \u8a55\u5206\u70ba -0.73 \u5206\u3002<\/i><\/p>\n

Skyhawk \u4ea6\u5ba3\u4f48 SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u81f3\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90 \u540d\u60a3\u8005\u670d\u7528\u8a72\u85e5\u7269\u3002<\/i><\/p>\n

\u6ce2\u58eb\u9813<\/span>2026\u5e741\u670829\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —
Skyhawk Therapeutics, Inc.<\/span> <\/div>\n

SKY-0515 \u53ef\u4f7f\u8840\u6db2\u4e2d\u7684 mHTT \u86cb\u767d\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e\uff0c\u5728 9 \u6beb\u514b\u5291\u91cf\u4e0b\u6e1b\u5e45\u9054 62%\uff0c\u540c\u6642 PMS1 mRNA \u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e 26%\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u5f35\u548c HD \u75c5\u7406\u7684\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\u3002 SKY-0515 \u4ea6\u8868\u73fe\u51fa\u512a\u7570\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u85e5\u7269\u66b4\u9732\u5ea6\uff0c\u6574\u9ad4\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n

\u5728 SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57 C \u90e8\u5206\u60a3\u8005\u7fa4\u7d44\u4e2d\uff0c\u63a5\u53d7 SKY-0515 \u6cbb\u7642\u7684\u60a3\u8005\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u6642\uff0c\u5176\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u5e73\u5747\u8a55\u5206\u8f03\u57fa\u7dda\u6709\u6240\u6539\u5584\u3002 \u5728\u4e5d\u500b\u6708\u6642\u7684\u5408\u4f75\u5206\u6790\u4e2d\uff0c\u6839\u64da\u4f7f\u7528 Enroll-HD \u53ca TRACK-HD \u7684\u50be\u5411\u8a55\u5206\u52a0\u6b0a\u7d50\u679c\uff0c\u8207\u6709\u75c7\u72c0\u60a3\u8005\u4e5d\u500b\u6708\u60e1\u5316\u7684 -0.73 cUHDRS \u8a55\u5206\u76f8\u6bd4\uff0c\u5728\u4e5d\u500b\u6708\u7684\u6539\u5584\u70ba +0.64 \u5206\u3002<\/p>\n

\u502b\u6566\u5927\u5b78\u5b78\u9662\u795e\u7d93\u75c5\u5b78\u6559\u6388 Ed Wild \u8868\u793a\uff1a\u300c\u6211\u5c0d\u5728 SKY-0515 \u7b2c 1 \u671f C \u90e8\u5206\u8a66\u9a57\u60a3\u8005\u4e2d\u7372\u5f97\u7684\u5b89\u5168\u6027\u548c\u65e9\u671f\u7642\u6548\u6578\u64da\u611f\u5230\u975e\u5e38\u9f13\u821e\u3002\u6578\u64da\u986f\u793a\uff0c\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u7684\u9810\u8a2d\u5206\u6790\u4e2d\uff0ccUHDRS \u8a55\u5206\u8207\u9810\u671f\u7684\u81ea\u7136\u75c5\u7a0b\u60e1\u5316\u8da8\u52e2\u76f8\u6096\u3002 SKY-0515 \u6301\u7e8c\u964d\u4f4e mHTT \u86cb\u767d\u6c34\u5e73\uff0c\u5728\u60a3\u8005\u8eab\u4e0a\u6e2c\u8a66\u7684\u4efb\u4f55\u7642\u6cd5\u4e2d\uff0c\u5176\u6548\u679c\u8fc4\u4eca\u70ba\u6b62\u6700\u986f\u8457\u3002\u800c\u81e8\u5e8a\u548c\u751f\u7269\u6a19\u8a18\u6578\u64da\u8868\u660e\uff0c\u8a72\u85e5\u7269\u5728\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 SKY-0515 \u80fd\u5920\u540c\u6642\u964d\u4f4e mHTT \u548c PMS1 \u7684\u6c34\u5e73\uff0c\u5f9e\u800c\u70ba\u900f\u904e Huntington \u75be\u75c5\u7684\u5169\u500b\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u6cbb\u7642\u8a72\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u4e00\u7a2e\u6709\u6548\u7684\u7d44\u5408\u3002 \u9019\u4e9b\u958b\u653e\u6a19\u7c64\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u6b63\u5728\u9032\u884c\u7684\u5b89\u6170\u5291\u5c0d\u7167 FALCON-HD \u8a66\u9a57\u4e2d\u9a57\u8b49\uff0c\u9810\u8a08\u5c07\u5c0d\u5168\u4e16\u754c\u7684 HD \u60a3\u8005\u7522\u751f\u6709\u610f\u7fa9\u7684\u5f71\u97ff\u3002\u5c0d\u65bc\u4ed6\u5011\u4f86\u8aaa\uff0c\u50cf SKY-0515 \u9019\u6a23\u7684\u53e3\u670d Huntington \u964d\u4f4e\u6cbb\u7642\u5c07\u771f\u6b63\u5177\u6709\u8b8a\u9769\u6027\u610f\u7fa9\u3002\u300d<\/p>\n

Skyhawk Therapeutics \u7814\u767c\u4e3b\u7ba1 Sergey Paushkin \u8868\u793a\uff1a\u300c\u6211\u5011\u9032\u884c\u7b2c I \u671f\u7814\u7a76\u7684\u76ee\u6a19\u662f\u78ba\u5b9a SKY-0515 \u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u6a19\u8a18\u6d3b\u6027\u3002\u800c\u5176\u751f\u7269\u6a19\u8a18\u53cd\u61c9\u5728\u6211\u5011\u4e5d\u500b\u6708\u7684\u4e2d\u671f\u6578\u64da\u5206\u6790\u4e2d\u6301\u7e8c\u5f37\u52c1\uff0c\u4e26\u4e14\u8207\u60a3\u8005\u81ea\u7136\u75c5\u7a0b\u6578\u64da\u4e2d cUHDRS \u8a55\u5206\u7684\u60e1\u5316\u76f8\u6bd4\uff0c\u6f5b\u5728\u7d42\u9ede cUHDRS \u6709\u6240\u6539\u5584\uff0c\u9019\u5f70\u986f\u4e86 SKY-0515 \u4f5c\u70ba HD \u6700\u4f73\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6f5b\u529b\u3002 \u9019\u4e9b\u4e2d\u671f\u6578\u64da\u4ee3\u8868 SKY-0515 \u7684\u4e00\u500b\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u4e26\u7a81\u986f\u4e86 Skyhawk \u5e73\u53f0\u5728\u70ba\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6bc0\u6ec5\u6027\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u9996\u5275\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u5f37\u5927\u80fd\u529b\u3002\u300d<\/p>\n

Huntington \u75be\u75c5\u662f\u4e00\u7a2e\u7f55\u898b\u3001\u907a\u50b3\u6027\u3001\u6700\u7d42\u81f4\u547d\u7684\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u5728\u7f8e\u570b\u6709\u8d85\u904e 40,000 \u540d\u6709\u75c7\u72c0\u7684\u60a3\u8005\uff0c\u64da\u4f30\u8a08\u5168\u4e16\u754c\u6709\u6578\u5341\u842c\u4eba\u53d7\u5230\u5f71\u97ff\u3002 \u76ee\u524d\u5c1a\u7121\u6838\u51c6\u7684\u6cbb\u7642\u65b9\u6cd5\u53ef\u4ee5\u6e1b\u7de9\u6216\u963b\u6b62\u75be\u75c5\u60e1\u5316\u3002 SKY-0515 \u662f\u4e00\u7a2e\u53e3\u670d\u7684\u8a66\u9a57\u6027\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u5291\uff0c\u7531\u8a72\u516c\u53f8\u7684\u65b0\u578b RNA \u8abf\u7bc0\u5e73\u53f0 SKYSTAR\u00ae<\/sup> \u958b\u767c\u800c\u6210\u3002 SKY-0515 \u53ef\u5728\u6cbb\u7642\u5c64\u9762\u540c\u6642<\/i>\u964d\u4f4e HTT \u86cb\u767d\u548c PMS1 \u86cb\u767d\u7684\u6c34\u5e73\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u589e\u548c HD \u75c5\u7406\u7684\u53e6\u4e00\u500b\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\uff0c\u5176\u4f5c\u7528\u6709\u671b\u8207\u964d\u4f4e\u7a81\u8b8a HTT \u6240\u5e36\u4f86\u7684\u76ca\u8655\u76f8\u8f14\u76f8\u6210\u3002<\/p>\n

Skyhawk \u4eca\u5929\u4e5f\u5ba3\u4f48\uff0c\u5176\u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d\u7684 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u958b\u5c55\u7684 SKY-0515 \u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u5230\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90\u540d\u60a3\u8005\u670d\u7528 SKY-0515\u3002<\/i>\u00a0<\/p>\n

SKY-0515 \u662f Skyhawk \u9996\u7a2e\u63a5\u53d7\u81e8\u5e8a\u8a66\u9a57\u7684\u85e5\u7269\u3002<\/p>\n

Skyhawk \u9810\u8a08\u5230 2027 \u5e74\u5e95\uff0c\u5c07\u63a8\u52d5\u66f4\u591a\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u7528\u65bc\u6cbb\u7642\u76ee\u524d\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u6539\u5584\u7642\u6cd5\u7684\u7f55\u898b\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002<\/p>\n

\u95dc\u65bc SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u7814\u7a76\u00a0
<\/b>SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u548c\u65e9\u671fHuntington \u75be\u75c5 (HD) \u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u7269\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002 \u8a66\u9a57\u5206\u70ba\u4e09\u90e8\u5206\u3002 A \u90e8\u5206\u548c B \u90e8\u5206\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684\u8868\u73fe\u3002 C \u90e8\u5206\u662f\u4e00\u9805\u96d9\u76f2\u5b89\u6170\u5291\u5c0d\u7167\u5e73\u884c\u8a2d\u8a08\u7814\u7a76\uff0c\u7814\u7a76 SKY-0515 \u7684\u5169\u7a2e\u5291\u91cf\u6c34\u5e73\u548c\u5b89\u6170\u5291\u5c0d\u65e9\u671f HD\uff08HD-ISS 1 \u671f\u30012 \u671f\u6216\u8f15\u5ea6 3 \u671f\uff09\u60a3\u8005\u9032\u884c 84 \u5929\u7684\u6cbb\u7642\uff0c\u96a8\u5f8c\u9032\u884c 12 \u500b\u6708\u7684\u6d3b\u6027\u6cbb\u7642\u5ef6\u9577\uff0c\u6240\u6709\u53c3\u8207\u8005\u5c07\u4ee5\u76f2\u6cd5\u63a5\u53d7\u4f4e\u5291\u91cf\u6216\u9ad8\u5291\u91cf\u7684 SKY-0515\u3002 \u7814\u7a76\u7684\u76ee\u6a19\u5305\u62ec\u8a55\u4f30\u7a81\u8b8a\u578b HTT \u86cb\u767d\u548c PMS1 mRNA\u3002 SKY-0515 C \u90e8\u5206\u7684\u9996\u6279\u60a3\u8005\u65bc 2025 \u5e74 1 \u6708\u63a5\u53d7\u85e5\u7269\u3002 \u73fe\u5df2\u5b8c\u6210\u62db\u52df SKY-0515 \u8a66\u9a57\u7b2c 1C \u671f\u53d7\u8a66\u8005\u3002<\/p>\n

\u95dc\u65bc SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u81e8\u5e8a\u7814\u7a76\u00a0
<\/b> FALCON-HD<\/b>\u00a0(NCT06873334<\/a>) \u662f\u4e00\u9805\u7b2c 2\/3 \u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u5291\u91cf\u7bc4\u570d\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u7684 120 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\uff0c\u4ee5\u53ca\u5168\u7403 40 \u591a\u500b\u7814\u7a76\u4e2d\u5fc3\u7684 400 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\u4e2d\u7684\u85e5\u6548\u5b78\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u5c07\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d SKY-0515\uff08\u4e09\u7a2e\u5291\u91cf\u6c34\u5e73\u4e4b\u4e00\uff09\u6216\u5b89\u6170\u5291\uff0c\u6cbb\u7642\u671f\u81f3\u5c11\u70ba 12 \u500b\u6708\u3002 \u8a66\u9a57\u65e8\u5728\u8a55\u4f30 SKY-0515 \u8abf\u7bc0 RNA \u62fc\u63a5\u548c\u6e1b\u5c11 mHTT \u548c PMS1 \u86cb\u767d\u7684\u6f5b\u529b\uff0c\u9019\u4e9b\u86cb\u767d\u8207 Huntington \u75be\u75c5\u7684\u75c5\u7406\u6709\u95dc\u3002 \u6709\u95dc FALCON-HD \u7684\u66f4\u591a\u8cc7\u8a0a\uff0c\u5305\u62ec\u53c3\u8207\u7684\u7814\u7a76\u4e2d\u5fc3\u548c\u8cc7\u683c\u6a19\u6e96\uff0c\u8acb\u700f\u89bd\uff1aClinicalTrials.gov<\/a>\u00a0\u548c\u00a0www.FALCON-HD.com<\/a>\u3002<\/p>\n

\u95dc\u65bc Skyhawk Therapeutics
<\/b>Skyhawk Therapeutics \u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5229\u7528\u5176\u5c08\u6709\u7684\u5e73\u53f0 SKYSTAR\u00ae<\/sup> \u767c\u73fe\u548c\u958b\u767c\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u7642\u6cd5\uff0c\u4ee5\u7528\u65bc\u6cbb\u7642\u4e16\u754c\u4e0a\u6700\u96e3\u6cbb\u7684\u75be\u75c5\u3002 \u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.skyhawktx.com<\/a>\u3002<\/p>\n

Skyhawk \u806f\u7d61\u4eba
<\/b>Maura McCarthy
\u4f01\u696d\u767c\u5c55\u4e3b\u7ba1
maura@skyhawktx.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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\u86cb\u767d\u6c34\u5e73\uff0c\u5728\u60a3\u8005\u8eab\u4e0a\u6e2c\u8a66\u7684\u4efb\u4f55\u7642\u6cd5\u4e2d\uff0c\u5176\u6548\u679c\u8fc4\u4eca\u70ba\u6b62\u6700\u986f\u8457\u3002\u800c\u81e8\u5e8a\u548c\u751f\u7269\u6a19\u8a18\u6578\u64da\u8868\u660e\uff0c\u8a72\u85e5\u7269\u5728\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 SKY-0515 \u80fd\u5920\u540c\u6642\u964d\u4f4e mHTT \u548c PMS1 \u7684\u6c34\u5e73\uff0c\u5f9e\u800c\u70ba\u900f\u904e Huntington \u75be\u75c5\u7684\u5169\u500b\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u6cbb\u7642\u8a72\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u4e00\u7a2e\u6709\u6548\u7684\u7d44\u5408\u3002 \u9019\u4e9b\u958b\u653e\u6a19\u7c64\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u6b63\u5728\u9032\u884c\u7684\u5b89\u6170\u5291\u5c0d\u7167 FALCON-HD \u8a66\u9a57\u4e2d\u9a57\u8b49\uff0c\u9810\u8a08\u5c07\u5c0d\u5168\u4e16\u754c\u7684 HD 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FALCON-HD\u00a0(NCT06873334) \u662f\u4e00\u9805\u7b2c 2\/3 \u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u5291\u91cf\u7bc4\u570d\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u7684 120 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\uff0c\u4ee5\u53ca\u5168\u7403 40 \u591a\u500b\u7814\u7a76\u4e2d\u5fc3\u7684 400 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\u4e2d\u7684\u85e5\u6548\u5b78\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u5c07\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d SKY-0515\uff08\u4e09\u7a2e\u5291\u91cf\u6c34\u5e73\u4e4b\u4e00\uff09\u6216\u5b89\u6170\u5291\uff0c\u6cbb\u7642\u671f\u81f3\u5c11\u70ba 12 \u500b\u6708\u3002 \u8a66\u9a57\u65e8\u5728\u8a55\u4f30 SKY-0515 \u8abf\u7bc0 RNA \u62fc\u63a5\u548c\u6e1b\u5c11 mHTT \u548c PMS1 \u86cb\u767d\u7684\u6f5b\u529b\uff0c\u9019\u4e9b\u86cb\u767d\u8207 Huntington \u75be\u75c5\u7684\u75c5\u7406\u6709\u95dc\u3002 \u6709\u95dc FALCON-HD \u7684\u66f4\u591a\u8cc7\u8a0a\uff0c\u5305\u62ec\u53c3\u8207\u7684\u7814\u7a76\u4e2d\u5fc3\u548c\u8cc7\u683c\u6a19\u6e96\uff0c\u8acb\u700f\u89bd\uff1aClinicalTrials.gov\u00a0\u548c\u00a0www.FALCON-HD.com\u3002 \u95dc\u65bc Skyhawk TherapeuticsSkyhawk Therapeutics \u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5229\u7528\u5176\u5c08\u6709\u7684\u5e73\u53f0 SKYSTAR\u00ae \u767c\u73fe\u548c\u958b\u767c\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u7642\u6cd5\uff0c\u4ee5\u7528\u65bc\u6cbb\u7642\u4e16\u754c\u4e0a\u6700\u96e3\u6cbb\u7684\u75be\u75c5\u3002 \u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.skyhawktx.com\u3002 Skyhawk \u806f\u7d61\u4ebaMaura McCarthy\u4f01\u696d\u767c\u5c55\u4e3b\u7ba1maura@skyhawktx.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=405894\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Skyhawk Therapeutics \u516c\u4f48\u5176\u7528\u65bc\u6cbb\u7642 Huntington \u75be\u75c5\u7684\u85e5\u7269 SKY-0515 \u65bc\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d \u53d7\u8a66\u60a3\u8005\u7684\u4e5d\u500b\u6708\u4e2d\u671f\u7d50\u679c\u3002 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u4e5d\u500b\u6708\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u8a55\u5206\u8f03\u57fa\u7dda\u5e73\u5747\u6539\u5584 +0.64 \u5206\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6839\u64da\u50be\u5411\u8a55\u5206\u52a0\u6b0a\uff0c\u6709\u75c7\u72c0\u60a3\u8005\u7684\u4e5d\u500b\u6708\u81ea\u7136\u60e1\u5316 cUHDRS \u8a55\u5206\u70ba -0.73 \u5206\u3002 Skyhawk \u4ea6\u5ba3\u4f48 SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u81f3\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90 \u540d\u60a3\u8005\u670d\u7528\u8a72\u85e5\u7269\u3002 \u6ce2\u58eb\u98132026\u5e741\u670829\u65e5 \/\u7f8e\u901a\u793e\/ -- Skyhawk Therapeutics, Inc. SKY-0515 \u53ef\u4f7f\u8840\u6db2\u4e2d\u7684 mHTT \u86cb\u767d\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e\uff0c\u5728 9 \u6beb\u514b\u5291\u91cf\u4e0b\u6e1b\u5e45\u9054 62%\uff0c\u540c\u6642 PMS1 mRNA \u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e 26%\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u5f35\u548c HD \u75c5\u7406\u7684\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\u3002 SKY-0515 \u4ea6\u8868\u73fe\u51fa\u512a\u7570\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u85e5\u7269\u66b4\u9732\u5ea6\uff0c\u6574\u9ad4\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u5728 SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57 C \u90e8\u5206\u60a3\u8005\u7fa4\u7d44\u4e2d\uff0c\u63a5\u53d7 SKY-0515 \u6cbb\u7642\u7684\u60a3\u8005\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u6642\uff0c\u5176\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u5e73\u5747\u8a55\u5206\u8f03\u57fa\u7dda\u6709\u6240\u6539\u5584\u3002 \u5728\u4e5d\u500b\u6708\u6642\u7684\u5408\u4f75\u5206\u6790\u4e2d\uff0c\u6839\u64da\u4f7f\u7528 Enroll-HD \u53ca TRACK-HD \u7684\u50be\u5411\u8a55\u5206\u52a0\u6b0a\u7d50\u679c\uff0c\u8207\u6709\u75c7\u72c0\u60a3\u8005\u4e5d\u500b\u6708\u60e1\u5316\u7684 -0.73 cUHDRS \u8a55\u5206\u76f8\u6bd4\uff0c\u5728\u4e5d\u500b\u6708\u7684\u6539\u5584\u70ba +0.64 \u5206\u3002 \u502b\u6566\u5927\u5b78\u5b78\u9662\u795e\u7d93\u75c5\u5b78\u6559\u6388 Ed Wild \u8868\u793a\uff1a\u300c\u6211\u5c0d\u5728 SKY-0515 \u7b2c 1 \u671f C \u90e8\u5206\u8a66\u9a57\u60a3\u8005\u4e2d\u7372\u5f97\u7684\u5b89\u5168\u6027\u548c\u65e9\u671f\u7642\u6548\u6578\u64da\u611f\u5230\u975e\u5e38\u9f13\u821e\u3002\u6578\u64da\u986f\u793a\uff0c\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u7684\u9810\u8a2d\u5206\u6790\u4e2d\uff0ccUHDRS \u8a55\u5206\u8207\u9810\u671f\u7684\u81ea\u7136\u75c5\u7a0b\u60e1\u5316\u8da8\u52e2\u76f8\u6096\u3002 SKY-0515 \u6301\u7e8c\u964d\u4f4e mHTT \u86cb\u767d\u6c34\u5e73\uff0c\u5728\u60a3\u8005\u8eab\u4e0a\u6e2c\u8a66\u7684\u4efb\u4f55\u7642\u6cd5\u4e2d\uff0c\u5176\u6548\u679c\u8fc4\u4eca\u70ba\u6b62\u6700\u986f\u8457\u3002\u800c\u81e8\u5e8a\u548c\u751f\u7269\u6a19\u8a18\u6578\u64da\u8868\u660e\uff0c\u8a72\u85e5\u7269\u5728\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 SKY-0515 \u80fd\u5920\u540c\u6642\u964d\u4f4e mHTT \u548c PMS1 \u7684\u6c34\u5e73\uff0c\u5f9e\u800c\u70ba\u900f\u904e Huntington \u75be\u75c5\u7684\u5169\u500b\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u6cbb\u7642\u8a72\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u4e00\u7a2e\u6709\u6548\u7684\u7d44\u5408\u3002 \u9019\u4e9b\u958b\u653e\u6a19\u7c64\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u6b63\u5728\u9032\u884c\u7684\u5b89\u6170\u5291\u5c0d\u7167 FALCON-HD \u8a66\u9a57\u4e2d\u9a57\u8b49\uff0c\u9810\u8a08\u5c07\u5c0d\u5168\u4e16\u754c\u7684 HD \u60a3\u8005\u7522\u751f\u6709\u610f\u7fa9\u7684\u5f71\u97ff\u3002\u5c0d\u65bc\u4ed6\u5011\u4f86\u8aaa\uff0c\u50cf SKY-0515 \u9019\u6a23\u7684\u53e3\u670d Huntington \u964d\u4f4e\u6cbb\u7642\u5c07\u771f\u6b63\u5177\u6709\u8b8a\u9769\u6027\u610f\u7fa9\u3002\u300d Skyhawk Therapeutics \u7814\u767c\u4e3b\u7ba1 Sergey Paushkin \u8868\u793a\uff1a\u300c\u6211\u5011\u9032\u884c\u7b2c I \u671f\u7814\u7a76\u7684\u76ee\u6a19\u662f\u78ba\u5b9a SKY-0515 \u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u6a19\u8a18\u6d3b\u6027\u3002\u800c\u5176\u751f\u7269\u6a19\u8a18\u53cd\u61c9\u5728\u6211\u5011\u4e5d\u500b\u6708\u7684\u4e2d\u671f\u6578\u64da\u5206\u6790\u4e2d\u6301\u7e8c\u5f37\u52c1\uff0c\u4e26\u4e14\u8207\u60a3\u8005\u81ea\u7136\u75c5\u7a0b\u6578\u64da\u4e2d cUHDRS \u8a55\u5206\u7684\u60e1\u5316\u76f8\u6bd4\uff0c\u6f5b\u5728\u7d42\u9ede cUHDRS \u6709\u6240\u6539\u5584\uff0c\u9019\u5f70\u986f\u4e86 SKY-0515 \u4f5c\u70ba HD \u6700\u4f73\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6f5b\u529b\u3002 \u9019\u4e9b\u4e2d\u671f\u6578\u64da\u4ee3\u8868 SKY-0515 \u7684\u4e00\u500b\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u4e26\u7a81\u986f\u4e86 Skyhawk \u5e73\u53f0\u5728\u70ba\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6bc0\u6ec5\u6027\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u9996\u5275\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u5f37\u5927\u80fd\u529b\u3002\u300d Huntington \u75be\u75c5\u662f\u4e00\u7a2e\u7f55\u898b\u3001\u907a\u50b3\u6027\u3001\u6700\u7d42\u81f4\u547d\u7684\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u5728\u7f8e\u570b\u6709\u8d85\u904e 40,000 \u540d\u6709\u75c7\u72c0\u7684\u60a3\u8005\uff0c\u64da\u4f30\u8a08\u5168\u4e16\u754c\u6709\u6578\u5341\u842c\u4eba\u53d7\u5230\u5f71\u97ff\u3002 \u76ee\u524d\u5c1a\u7121\u6838\u51c6\u7684\u6cbb\u7642\u65b9\u6cd5\u53ef\u4ee5\u6e1b\u7de9\u6216\u963b\u6b62\u75be\u75c5\u60e1\u5316\u3002 SKY-0515 \u662f\u4e00\u7a2e\u53e3\u670d\u7684\u8a66\u9a57\u6027\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u5291\uff0c\u7531\u8a72\u516c\u53f8\u7684\u65b0\u578b RNA \u8abf\u7bc0\u5e73\u53f0 SKYSTAR\u00ae \u958b\u767c\u800c\u6210\u3002 SKY-0515 \u53ef\u5728\u6cbb\u7642\u5c64\u9762\u540c\u6642\u964d\u4f4e HTT \u86cb\u767d\u548c PMS1 \u86cb\u767d\u7684\u6c34\u5e73\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u589e\u548c HD \u75c5\u7406\u7684\u53e6\u4e00\u500b\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\uff0c\u5176\u4f5c\u7528\u6709\u671b\u8207\u964d\u4f4e\u7a81\u8b8a HTT \u6240\u5e36\u4f86\u7684\u76ca\u8655\u76f8\u8f14\u76f8\u6210\u3002 Skyhawk \u4eca\u5929\u4e5f\u5ba3\u4f48\uff0c\u5176\u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d\u7684 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u958b\u5c55\u7684 SKY-0515 \u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u5230\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90\u540d\u60a3\u8005\u670d\u7528 SKY-0515\u3002\u00a0 SKY-0515 \u662f Skyhawk \u9996\u7a2e\u63a5\u53d7\u81e8\u5e8a\u8a66\u9a57\u7684\u85e5\u7269\u3002 Skyhawk \u9810\u8a08\u5230 2027 \u5e74\u5e95\uff0c\u5c07\u63a8\u52d5\u66f4\u591a\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u7528\u65bc\u6cbb\u7642\u76ee\u524d\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u6539\u5584\u7642\u6cd5\u7684\u7f55\u898b\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002 \u95dc\u65bc SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u7814\u7a76\u00a0SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u548c\u65e9\u671fHuntington \u75be\u75c5 (HD) \u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u7269\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002 \u8a66\u9a57\u5206\u70ba\u4e09\u90e8\u5206\u3002 A \u90e8\u5206\u548c B \u90e8\u5206\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684\u8868\u73fe\u3002 C \u90e8\u5206\u662f\u4e00\u9805\u96d9\u76f2\u5b89\u6170\u5291\u5c0d\u7167\u5e73\u884c\u8a2d\u8a08\u7814\u7a76\uff0c\u7814\u7a76 SKY-0515 \u7684\u5169\u7a2e\u5291\u91cf\u6c34\u5e73\u548c\u5b89\u6170\u5291\u5c0d\u65e9\u671f HD\uff08HD-ISS 1 \u671f\u30012 \u671f\u6216\u8f15\u5ea6 3 \u671f\uff09\u60a3\u8005\u9032\u884c 84 \u5929\u7684\u6cbb\u7642\uff0c\u96a8\u5f8c\u9032\u884c 12 \u500b\u6708\u7684\u6d3b\u6027\u6cbb\u7642\u5ef6\u9577\uff0c\u6240\u6709\u53c3\u8207\u8005\u5c07\u4ee5\u76f2\u6cd5\u63a5\u53d7\u4f4e\u5291\u91cf\u6216\u9ad8\u5291\u91cf\u7684 SKY-0515\u3002 \u7814\u7a76\u7684\u76ee\u6a19\u5305\u62ec\u8a55\u4f30\u7a81\u8b8a\u578b HTT \u86cb\u767d\u548c PMS1 mRNA\u3002 SKY-0515 C \u90e8\u5206\u7684\u9996\u6279\u60a3\u8005\u65bc 2025 \u5e74 1 \u6708\u63a5\u53d7\u85e5\u7269\u3002 \u73fe\u5df2\u5b8c\u6210\u62db\u52df SKY-0515 \u8a66\u9a57\u7b2c 1C \u671f\u53d7\u8a66\u8005\u3002 \u95dc\u65bc SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u81e8\u5e8a\u7814\u7a76\u00a0 FALCON-HD\u00a0(NCT06873334) \u662f\u4e00\u9805\u7b2c 2\/3 \u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u5291\u91cf\u7bc4\u570d\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u7684 120 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\uff0c\u4ee5\u53ca\u5168\u7403 40 \u591a\u500b\u7814\u7a76\u4e2d\u5fc3\u7684 400 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\u4e2d\u7684\u85e5\u6548\u5b78\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u5c07\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d SKY-0515\uff08\u4e09\u7a2e\u5291\u91cf\u6c34\u5e73\u4e4b\u4e00\uff09\u6216\u5b89\u6170\u5291\uff0c\u6cbb\u7642\u671f\u81f3\u5c11\u70ba 12 \u500b\u6708\u3002 \u8a66\u9a57\u65e8\u5728\u8a55\u4f30 SKY-0515 \u8abf\u7bc0 RNA \u62fc\u63a5\u548c\u6e1b\u5c11 mHTT \u548c PMS1 \u86cb\u767d\u7684\u6f5b\u529b\uff0c\u9019\u4e9b\u86cb\u767d\u8207 Huntington \u75be\u75c5\u7684\u75c5\u7406\u6709\u95dc\u3002 \u6709\u95dc FALCON-HD \u7684\u66f4\u591a\u8cc7\u8a0a\uff0c\u5305\u62ec\u53c3\u8207\u7684\u7814\u7a76\u4e2d\u5fc3\u548c\u8cc7\u683c\u6a19\u6e96\uff0c\u8acb\u700f\u89bd\uff1aClinicalTrials.gov\u00a0\u548c\u00a0www.FALCON-HD.com\u3002 \u95dc\u65bc Skyhawk TherapeuticsSkyhawk Therapeutics \u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5229\u7528\u5176\u5c08\u6709\u7684\u5e73\u53f0 SKYSTAR\u00ae \u767c\u73fe\u548c\u958b\u767c\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u7642\u6cd5\uff0c\u4ee5\u7528\u65bc\u6cbb\u7642\u4e16\u754c\u4e0a\u6700\u96e3\u6cbb\u7684\u75be\u75c5\u3002 \u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.skyhawktx.com\u3002 Skyhawk \u806f\u7d61\u4ebaMaura McCarthy\u4f01\u696d\u767c\u5c55\u4e3b\u7ba1maura@skyhawktx.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=405894\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-29T13:05:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnasia.com\/media2\/710814\/Skyhawk_Therapeutics_Logo.jpg?p=medium600\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=405894#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=405894\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"Skyhawk Therapeutics \u516c\u4f48\u5176\u7528\u65bc\u6cbb\u7642 Huntington \u75be\u75c5\u7684\u85e5\u7269 SKY-0515 \u65bc\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d 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\u53d7\u8a66\u60a3\u8005\u7684\u4e5d\u500b\u6708\u4e2d\u671f\u7d50\u679c\u3002 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=405894#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=405894#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2026\\\/01\\\/Skyhawk_Therapeutics_9_MONTH_DATA_Graph.jpg\",\"datePublished\":\"2026-01-29T13:05:00+00:00\",\"description\":\"\u4e5d\u500b\u6708\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u8a55\u5206\u8f03\u57fa\u7dda\u5e73\u5747\u6539\u5584 +0.64 \u5206\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6839\u64da\u50be\u5411\u8a55\u5206\u52a0\u6b0a\uff0c\u6709\u75c7\u72c0\u60a3\u8005\u7684\u4e5d\u500b\u6708\u81ea\u7136\u60e1\u5316 cUHDRS \u8a55\u5206\u70ba -0.73 \u5206\u3002 Skyhawk \u4ea6\u5ba3\u4f48 SKY-0515 \u7684\u7b2c 2\\\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u81f3\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90 \u540d\u60a3\u8005\u670d\u7528\u8a72\u85e5\u7269\u3002 \u6ce2\u58eb\u98132026\u5e741\u670829\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- Skyhawk Therapeutics, Inc. SKY-0515 \u53ef\u4f7f\u8840\u6db2\u4e2d\u7684 mHTT \u86cb\u767d\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e\uff0c\u5728 9 \u6beb\u514b\u5291\u91cf\u4e0b\u6e1b\u5e45\u9054 62%\uff0c\u540c\u6642 PMS1 mRNA \u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e 26%\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u5f35\u548c HD \u75c5\u7406\u7684\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\u3002 SKY-0515 \u4ea6\u8868\u73fe\u51fa\u512a\u7570\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u85e5\u7269\u66b4\u9732\u5ea6\uff0c\u6574\u9ad4\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u5728 SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57 C \u90e8\u5206\u60a3\u8005\u7fa4\u7d44\u4e2d\uff0c\u63a5\u53d7 SKY-0515 \u6cbb\u7642\u7684\u60a3\u8005\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u6642\uff0c\u5176\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u5e73\u5747\u8a55\u5206\u8f03\u57fa\u7dda\u6709\u6240\u6539\u5584\u3002 \u5728\u4e5d\u500b\u6708\u6642\u7684\u5408\u4f75\u5206\u6790\u4e2d\uff0c\u6839\u64da\u4f7f\u7528 Enroll-HD \u53ca TRACK-HD \u7684\u50be\u5411\u8a55\u5206\u52a0\u6b0a\u7d50\u679c\uff0c\u8207\u6709\u75c7\u72c0\u60a3\u8005\u4e5d\u500b\u6708\u60e1\u5316\u7684 -0.73 cUHDRS \u8a55\u5206\u76f8\u6bd4\uff0c\u5728\u4e5d\u500b\u6708\u7684\u6539\u5584\u70ba +0.64 \u5206\u3002 \u502b\u6566\u5927\u5b78\u5b78\u9662\u795e\u7d93\u75c5\u5b78\u6559\u6388 Ed Wild \u8868\u793a\uff1a\u300c\u6211\u5c0d\u5728 SKY-0515 \u7b2c 1 \u671f C \u90e8\u5206\u8a66\u9a57\u60a3\u8005\u4e2d\u7372\u5f97\u7684\u5b89\u5168\u6027\u548c\u65e9\u671f\u7642\u6548\u6578\u64da\u611f\u5230\u975e\u5e38\u9f13\u821e\u3002\u6578\u64da\u986f\u793a\uff0c\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u7684\u9810\u8a2d\u5206\u6790\u4e2d\uff0ccUHDRS \u8a55\u5206\u8207\u9810\u671f\u7684\u81ea\u7136\u75c5\u7a0b\u60e1\u5316\u8da8\u52e2\u76f8\u6096\u3002 SKY-0515 \u6301\u7e8c\u964d\u4f4e mHTT \u86cb\u767d\u6c34\u5e73\uff0c\u5728\u60a3\u8005\u8eab\u4e0a\u6e2c\u8a66\u7684\u4efb\u4f55\u7642\u6cd5\u4e2d\uff0c\u5176\u6548\u679c\u8fc4\u4eca\u70ba\u6b62\u6700\u986f\u8457\u3002\u800c\u81e8\u5e8a\u548c\u751f\u7269\u6a19\u8a18\u6578\u64da\u8868\u660e\uff0c\u8a72\u85e5\u7269\u5728\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 SKY-0515 \u80fd\u5920\u540c\u6642\u964d\u4f4e mHTT \u548c PMS1 \u7684\u6c34\u5e73\uff0c\u5f9e\u800c\u70ba\u900f\u904e Huntington \u75be\u75c5\u7684\u5169\u500b\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u6cbb\u7642\u8a72\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u4e00\u7a2e\u6709\u6548\u7684\u7d44\u5408\u3002 \u9019\u4e9b\u958b\u653e\u6a19\u7c64\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u6b63\u5728\u9032\u884c\u7684\u5b89\u6170\u5291\u5c0d\u7167 FALCON-HD \u8a66\u9a57\u4e2d\u9a57\u8b49\uff0c\u9810\u8a08\u5c07\u5c0d\u5168\u4e16\u754c\u7684 HD 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\u540d\u60a3\u8005\u670d\u7528\u8a72\u85e5\u7269\u3002 \u6ce2\u58eb\u98132026\u5e741\u670829\u65e5 \/\u7f8e\u901a\u793e\/ -- Skyhawk Therapeutics, Inc. SKY-0515 \u53ef\u4f7f\u8840\u6db2\u4e2d\u7684 mHTT \u86cb\u767d\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e\uff0c\u5728 9 \u6beb\u514b\u5291\u91cf\u4e0b\u6e1b\u5e45\u9054 62%\uff0c\u540c\u6642 PMS1 mRNA \u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e 26%\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u5f35\u548c HD \u75c5\u7406\u7684\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\u3002 SKY-0515 \u4ea6\u8868\u73fe\u51fa\u512a\u7570\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u85e5\u7269\u66b4\u9732\u5ea6\uff0c\u6574\u9ad4\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u5728 SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57 C \u90e8\u5206\u60a3\u8005\u7fa4\u7d44\u4e2d\uff0c\u63a5\u53d7 SKY-0515 \u6cbb\u7642\u7684\u60a3\u8005\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u6642\uff0c\u5176\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u5e73\u5747\u8a55\u5206\u8f03\u57fa\u7dda\u6709\u6240\u6539\u5584\u3002 \u5728\u4e5d\u500b\u6708\u6642\u7684\u5408\u4f75\u5206\u6790\u4e2d\uff0c\u6839\u64da\u4f7f\u7528 Enroll-HD \u53ca TRACK-HD \u7684\u50be\u5411\u8a55\u5206\u52a0\u6b0a\u7d50\u679c\uff0c\u8207\u6709\u75c7\u72c0\u60a3\u8005\u4e5d\u500b\u6708\u60e1\u5316\u7684 -0.73 cUHDRS \u8a55\u5206\u76f8\u6bd4\uff0c\u5728\u4e5d\u500b\u6708\u7684\u6539\u5584\u70ba +0.64 \u5206\u3002 \u502b\u6566\u5927\u5b78\u5b78\u9662\u795e\u7d93\u75c5\u5b78\u6559\u6388 Ed Wild \u8868\u793a\uff1a\u300c\u6211\u5c0d\u5728 SKY-0515 \u7b2c 1 \u671f C \u90e8\u5206\u8a66\u9a57\u60a3\u8005\u4e2d\u7372\u5f97\u7684\u5b89\u5168\u6027\u548c\u65e9\u671f\u7642\u6548\u6578\u64da\u611f\u5230\u975e\u5e38\u9f13\u821e\u3002\u6578\u64da\u986f\u793a\uff0c\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u7684\u9810\u8a2d\u5206\u6790\u4e2d\uff0ccUHDRS \u8a55\u5206\u8207\u9810\u671f\u7684\u81ea\u7136\u75c5\u7a0b\u60e1\u5316\u8da8\u52e2\u76f8\u6096\u3002 SKY-0515 \u6301\u7e8c\u964d\u4f4e mHTT \u86cb\u767d\u6c34\u5e73\uff0c\u5728\u60a3\u8005\u8eab\u4e0a\u6e2c\u8a66\u7684\u4efb\u4f55\u7642\u6cd5\u4e2d\uff0c\u5176\u6548\u679c\u8fc4\u4eca\u70ba\u6b62\u6700\u986f\u8457\u3002\u800c\u81e8\u5e8a\u548c\u751f\u7269\u6a19\u8a18\u6578\u64da\u8868\u660e\uff0c\u8a72\u85e5\u7269\u5728\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 SKY-0515 \u80fd\u5920\u540c\u6642\u964d\u4f4e mHTT \u548c PMS1 \u7684\u6c34\u5e73\uff0c\u5f9e\u800c\u70ba\u900f\u904e Huntington \u75be\u75c5\u7684\u5169\u500b\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u6cbb\u7642\u8a72\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u4e00\u7a2e\u6709\u6548\u7684\u7d44\u5408\u3002 \u9019\u4e9b\u958b\u653e\u6a19\u7c64\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u6b63\u5728\u9032\u884c\u7684\u5b89\u6170\u5291\u5c0d\u7167 FALCON-HD \u8a66\u9a57\u4e2d\u9a57\u8b49\uff0c\u9810\u8a08\u5c07\u5c0d\u5168\u4e16\u754c\u7684 HD \u60a3\u8005\u7522\u751f\u6709\u610f\u7fa9\u7684\u5f71\u97ff\u3002\u5c0d\u65bc\u4ed6\u5011\u4f86\u8aaa\uff0c\u50cf SKY-0515 \u9019\u6a23\u7684\u53e3\u670d Huntington \u964d\u4f4e\u6cbb\u7642\u5c07\u771f\u6b63\u5177\u6709\u8b8a\u9769\u6027\u610f\u7fa9\u3002\u300d Skyhawk Therapeutics \u7814\u767c\u4e3b\u7ba1 Sergey Paushkin \u8868\u793a\uff1a\u300c\u6211\u5011\u9032\u884c\u7b2c I \u671f\u7814\u7a76\u7684\u76ee\u6a19\u662f\u78ba\u5b9a SKY-0515 \u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u6a19\u8a18\u6d3b\u6027\u3002\u800c\u5176\u751f\u7269\u6a19\u8a18\u53cd\u61c9\u5728\u6211\u5011\u4e5d\u500b\u6708\u7684\u4e2d\u671f\u6578\u64da\u5206\u6790\u4e2d\u6301\u7e8c\u5f37\u52c1\uff0c\u4e26\u4e14\u8207\u60a3\u8005\u81ea\u7136\u75c5\u7a0b\u6578\u64da\u4e2d cUHDRS \u8a55\u5206\u7684\u60e1\u5316\u76f8\u6bd4\uff0c\u6f5b\u5728\u7d42\u9ede cUHDRS \u6709\u6240\u6539\u5584\uff0c\u9019\u5f70\u986f\u4e86 SKY-0515 \u4f5c\u70ba HD \u6700\u4f73\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6f5b\u529b\u3002 \u9019\u4e9b\u4e2d\u671f\u6578\u64da\u4ee3\u8868 SKY-0515 \u7684\u4e00\u500b\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u4e26\u7a81\u986f\u4e86 Skyhawk \u5e73\u53f0\u5728\u70ba\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6bc0\u6ec5\u6027\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u9996\u5275\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u7684\u5f37\u5927\u80fd\u529b\u3002\u300d Huntington \u75be\u75c5\u662f\u4e00\u7a2e\u7f55\u898b\u3001\u907a\u50b3\u6027\u3001\u6700\u7d42\u81f4\u547d\u7684\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u5728\u7f8e\u570b\u6709\u8d85\u904e 40,000 \u540d\u6709\u75c7\u72c0\u7684\u60a3\u8005\uff0c\u64da\u4f30\u8a08\u5168\u4e16\u754c\u6709\u6578\u5341\u842c\u4eba\u53d7\u5230\u5f71\u97ff\u3002 \u76ee\u524d\u5c1a\u7121\u6838\u51c6\u7684\u6cbb\u7642\u65b9\u6cd5\u53ef\u4ee5\u6e1b\u7de9\u6216\u963b\u6b62\u75be\u75c5\u60e1\u5316\u3002 SKY-0515 \u662f\u4e00\u7a2e\u53e3\u670d\u7684\u8a66\u9a57\u6027\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u5291\uff0c\u7531\u8a72\u516c\u53f8\u7684\u65b0\u578b RNA \u8abf\u7bc0\u5e73\u53f0 SKYSTAR\u00ae \u958b\u767c\u800c\u6210\u3002 SKY-0515 \u53ef\u5728\u6cbb\u7642\u5c64\u9762\u540c\u6642\u964d\u4f4e HTT \u86cb\u767d\u548c PMS1 \u86cb\u767d\u7684\u6c34\u5e73\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u589e\u548c HD \u75c5\u7406\u7684\u53e6\u4e00\u500b\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\uff0c\u5176\u4f5c\u7528\u6709\u671b\u8207\u964d\u4f4e\u7a81\u8b8a HTT \u6240\u5e36\u4f86\u7684\u76ca\u8655\u76f8\u8f14\u76f8\u6210\u3002 Skyhawk \u4eca\u5929\u4e5f\u5ba3\u4f48\uff0c\u5176\u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d\u7684 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u958b\u5c55\u7684 SKY-0515 \u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u5230\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90\u540d\u60a3\u8005\u670d\u7528 SKY-0515\u3002\u00a0 SKY-0515 \u662f Skyhawk \u9996\u7a2e\u63a5\u53d7\u81e8\u5e8a\u8a66\u9a57\u7684\u85e5\u7269\u3002 Skyhawk \u9810\u8a08\u5230 2027 \u5e74\u5e95\uff0c\u5c07\u63a8\u52d5\u66f4\u591a\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u7528\u65bc\u6cbb\u7642\u76ee\u524d\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u6539\u5584\u7642\u6cd5\u7684\u7f55\u898b\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002 \u95dc\u65bc SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u7814\u7a76\u00a0SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u548c\u65e9\u671fHuntington \u75be\u75c5 (HD) \u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u7269\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002 \u8a66\u9a57\u5206\u70ba\u4e09\u90e8\u5206\u3002 A \u90e8\u5206\u548c B \u90e8\u5206\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684\u8868\u73fe\u3002 C \u90e8\u5206\u662f\u4e00\u9805\u96d9\u76f2\u5b89\u6170\u5291\u5c0d\u7167\u5e73\u884c\u8a2d\u8a08\u7814\u7a76\uff0c\u7814\u7a76 SKY-0515 \u7684\u5169\u7a2e\u5291\u91cf\u6c34\u5e73\u548c\u5b89\u6170\u5291\u5c0d\u65e9\u671f HD\uff08HD-ISS 1 \u671f\u30012 \u671f\u6216\u8f15\u5ea6 3 \u671f\uff09\u60a3\u8005\u9032\u884c 84 \u5929\u7684\u6cbb\u7642\uff0c\u96a8\u5f8c\u9032\u884c 12 \u500b\u6708\u7684\u6d3b\u6027\u6cbb\u7642\u5ef6\u9577\uff0c\u6240\u6709\u53c3\u8207\u8005\u5c07\u4ee5\u76f2\u6cd5\u63a5\u53d7\u4f4e\u5291\u91cf\u6216\u9ad8\u5291\u91cf\u7684 SKY-0515\u3002 \u7814\u7a76\u7684\u76ee\u6a19\u5305\u62ec\u8a55\u4f30\u7a81\u8b8a\u578b HTT \u86cb\u767d\u548c PMS1 mRNA\u3002 SKY-0515 C \u90e8\u5206\u7684\u9996\u6279\u60a3\u8005\u65bc 2025 \u5e74 1 \u6708\u63a5\u53d7\u85e5\u7269\u3002 \u73fe\u5df2\u5b8c\u6210\u62db\u52df SKY-0515 \u8a66\u9a57\u7b2c 1C \u671f\u53d7\u8a66\u8005\u3002 \u95dc\u65bc SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u81e8\u5e8a\u7814\u7a76\u00a0 FALCON-HD\u00a0(NCT06873334) \u662f\u4e00\u9805\u7b2c 2\/3 \u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u5291\u91cf\u7bc4\u570d\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u7684 120 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\uff0c\u4ee5\u53ca\u5168\u7403 40 \u591a\u500b\u7814\u7a76\u4e2d\u5fc3\u7684 400 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\u4e2d\u7684\u85e5\u6548\u5b78\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u5c07\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d SKY-0515\uff08\u4e09\u7a2e\u5291\u91cf\u6c34\u5e73\u4e4b\u4e00\uff09\u6216\u5b89\u6170\u5291\uff0c\u6cbb\u7642\u671f\u81f3\u5c11\u70ba 12 \u500b\u6708\u3002 \u8a66\u9a57\u65e8\u5728\u8a55\u4f30 SKY-0515 \u8abf\u7bc0 RNA \u62fc\u63a5\u548c\u6e1b\u5c11 mHTT \u548c PMS1 \u86cb\u767d\u7684\u6f5b\u529b\uff0c\u9019\u4e9b\u86cb\u767d\u8207 Huntington \u75be\u75c5\u7684\u75c5\u7406\u6709\u95dc\u3002 \u6709\u95dc FALCON-HD \u7684\u66f4\u591a\u8cc7\u8a0a\uff0c\u5305\u62ec\u53c3\u8207\u7684\u7814\u7a76\u4e2d\u5fc3\u548c\u8cc7\u683c\u6a19\u6e96\uff0c\u8acb\u700f\u89bd\uff1aClinicalTrials.gov\u00a0\u548c\u00a0www.FALCON-HD.com\u3002 \u95dc\u65bc Skyhawk TherapeuticsSkyhawk Therapeutics \u662f\u4e00\u5bb6\u81e8\u5e8a\u968e\u6bb5\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5229\u7528\u5176\u5c08\u6709\u7684\u5e73\u53f0 SKYSTAR\u00ae \u767c\u73fe\u548c\u958b\u767c\u5c0f\u5206\u5b50 RNA \u8abf\u7bc0\u7642\u6cd5\uff0c\u4ee5\u7528\u65bc\u6cbb\u7642\u4e16\u754c\u4e0a\u6700\u96e3\u6cbb\u7684\u75be\u75c5\u3002 \u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.skyhawktx.com\u3002 Skyhawk \u806f\u7d61\u4ebaMaura McCarthy\u4f01\u696d\u767c\u5c55\u4e3b\u7ba1maura@skyhawktx.com","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=405894","og_locale":"zh_TW","og_type":"article","og_title":"Skyhawk Therapeutics \u516c\u4f48\u5176\u7528\u65bc\u6cbb\u7642 Huntington \u75be\u75c5\u7684\u85e5\u7269 SKY-0515 \u65bc\u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d \u53d7\u8a66\u60a3\u8005\u7684\u4e5d\u500b\u6708\u4e2d\u671f\u7d50\u679c\u3002 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u4e5d\u500b\u6708\u7684\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u8a55\u5206\u8f03\u57fa\u7dda\u5e73\u5747\u6539\u5584 +0.64 \u5206\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6839\u64da\u50be\u5411\u8a55\u5206\u52a0\u6b0a\uff0c\u6709\u75c7\u72c0\u60a3\u8005\u7684\u4e5d\u500b\u6708\u81ea\u7136\u60e1\u5316 cUHDRS \u8a55\u5206\u70ba -0.73 \u5206\u3002 Skyhawk \u4ea6\u5ba3\u4f48 SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u81f3\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90 \u540d\u60a3\u8005\u670d\u7528\u8a72\u85e5\u7269\u3002 \u6ce2\u58eb\u98132026\u5e741\u670829\u65e5 \/\u7f8e\u901a\u793e\/ -- Skyhawk Therapeutics, Inc. SKY-0515 \u53ef\u4f7f\u8840\u6db2\u4e2d\u7684 mHTT \u86cb\u767d\u5448\u73fe\u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e\uff0c\u5728 9 \u6beb\u514b\u5291\u91cf\u4e0b\u6e1b\u5e45\u9054 62%\uff0c\u540c\u6642 PMS1 mRNA \u5291\u91cf\u4f9d\u8cf4\u6027\u964d\u4f4e 26%\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u5f35\u548c HD \u75c5\u7406\u7684\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\u3002 SKY-0515 \u4ea6\u8868\u73fe\u51fa\u512a\u7570\u7684\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u85e5\u7269\u66b4\u9732\u5ea6\uff0c\u6574\u9ad4\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u5728 SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57 C \u90e8\u5206\u60a3\u8005\u7fa4\u7d44\u4e2d\uff0c\u63a5\u53d7 SKY-0515 \u6cbb\u7642\u7684\u60a3\u8005\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u6642\uff0c\u5176\u7d9c\u5408\u7d71\u4e00 Huntington \u75be\u75c5\u8a55\u5206\u8868 (cUHDRS) \u7684\u5e73\u5747\u8a55\u5206\u8f03\u57fa\u7dda\u6709\u6240\u6539\u5584\u3002 \u5728\u4e5d\u500b\u6708\u6642\u7684\u5408\u4f75\u5206\u6790\u4e2d\uff0c\u6839\u64da\u4f7f\u7528 Enroll-HD \u53ca TRACK-HD \u7684\u50be\u5411\u8a55\u5206\u52a0\u6b0a\u7d50\u679c\uff0c\u8207\u6709\u75c7\u72c0\u60a3\u8005\u4e5d\u500b\u6708\u60e1\u5316\u7684 -0.73 cUHDRS \u8a55\u5206\u76f8\u6bd4\uff0c\u5728\u4e5d\u500b\u6708\u7684\u6539\u5584\u70ba +0.64 \u5206\u3002 \u502b\u6566\u5927\u5b78\u5b78\u9662\u795e\u7d93\u75c5\u5b78\u6559\u6388 Ed Wild \u8868\u793a\uff1a\u300c\u6211\u5c0d\u5728 SKY-0515 \u7b2c 1 \u671f C \u90e8\u5206\u8a66\u9a57\u60a3\u8005\u4e2d\u7372\u5f97\u7684\u5b89\u5168\u6027\u548c\u65e9\u671f\u7642\u6548\u6578\u64da\u611f\u5230\u975e\u5e38\u9f13\u821e\u3002\u6578\u64da\u986f\u793a\uff0c\u5728 3 \u500b\u6708\u30016 \u500b\u6708\u548c 9 \u500b\u6708\u7684\u9810\u8a2d\u5206\u6790\u4e2d\uff0ccUHDRS \u8a55\u5206\u8207\u9810\u671f\u7684\u81ea\u7136\u75c5\u7a0b\u60e1\u5316\u8da8\u52e2\u76f8\u6096\u3002 SKY-0515 \u6301\u7e8c\u964d\u4f4e mHTT \u86cb\u767d\u6c34\u5e73\uff0c\u5728\u60a3\u8005\u8eab\u4e0a\u6e2c\u8a66\u7684\u4efb\u4f55\u7642\u6cd5\u4e2d\uff0c\u5176\u6548\u679c\u8fc4\u4eca\u70ba\u6b62\u6700\u986f\u8457\u3002\u800c\u81e8\u5e8a\u548c\u751f\u7269\u6a19\u8a18\u6578\u64da\u8868\u660e\uff0c\u8a72\u85e5\u7269\u5728\u6240\u6709\u6e2c\u8a66\u5291\u91cf\u4e0b\u5747\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002 SKY-0515 \u80fd\u5920\u540c\u6642\u964d\u4f4e mHTT \u548c PMS1 \u7684\u6c34\u5e73\uff0c\u5f9e\u800c\u70ba\u900f\u904e Huntington \u75be\u75c5\u7684\u5169\u500b\u6838\u5fc3\u81f4\u75c5\u6a5f\u5236\u6cbb\u7642\u8a72\u75be\u75c5\u65b9\u9762\uff0c\u63d0\u4f9b\u4e00\u7a2e\u6709\u6548\u7684\u7d44\u5408\u3002 \u9019\u4e9b\u958b\u653e\u6a19\u7c64\u8a66\u9a57\u7d50\u679c\u5c07\u65bc\u6b63\u5728\u9032\u884c\u7684\u5b89\u6170\u5291\u5c0d\u7167 FALCON-HD \u8a66\u9a57\u4e2d\u9a57\u8b49\uff0c\u9810\u8a08\u5c07\u5c0d\u5168\u4e16\u754c\u7684 HD \u60a3\u8005\u7522\u751f\u6709\u610f\u7fa9\u7684\u5f71\u97ff\u3002\u5c0d\u65bc\u4ed6\u5011\u4f86\u8aaa\uff0c\u50cf SKY-0515 \u9019\u6a23\u7684\u53e3\u670d Huntington \u964d\u4f4e\u6cbb\u7642\u5c07\u771f\u6b63\u5177\u6709\u8b8a\u9769\u6027\u610f\u7fa9\u3002\u300d Skyhawk Therapeutics \u7814\u767c\u4e3b\u7ba1 Sergey Paushkin \u8868\u793a\uff1a\u300c\u6211\u5011\u9032\u884c\u7b2c I \u671f\u7814\u7a76\u7684\u76ee\u6a19\u662f\u78ba\u5b9a SKY-0515 \u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u6a19\u8a18\u6d3b\u6027\u3002\u800c\u5176\u751f\u7269\u6a19\u8a18\u53cd\u61c9\u5728\u6211\u5011\u4e5d\u500b\u6708\u7684\u4e2d\u671f\u6578\u64da\u5206\u6790\u4e2d\u6301\u7e8c\u5f37\u52c1\uff0c\u4e26\u4e14\u8207\u60a3\u8005\u81ea\u7136\u75c5\u7a0b\u6578\u64da\u4e2d cUHDRS \u8a55\u5206\u7684\u60e1\u5316\u76f8\u6bd4\uff0c\u6f5b\u5728\u7d42\u9ede cUHDRS \u6709\u6240\u6539\u5584\uff0c\u9019\u5f70\u986f\u4e86 SKY-0515 \u4f5c\u70ba HD \u6700\u4f73\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6f5b\u529b\u3002 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\u8abf\u7bc0\u5291\uff0c\u7531\u8a72\u516c\u53f8\u7684\u65b0\u578b RNA \u8abf\u7bc0\u5e73\u53f0 SKYSTAR\u00ae \u958b\u767c\u800c\u6210\u3002 SKY-0515 \u53ef\u5728\u6cbb\u7642\u5c64\u9762\u540c\u6642\u964d\u4f4e HTT \u86cb\u767d\u548c PMS1 \u86cb\u767d\u7684\u6c34\u5e73\u3002 PMS1 \u662f\u9ad4\u7d30\u80de CAG \u91cd\u8907\u5e8f\u5217\u64f4\u589e\u548c HD \u75c5\u7406\u7684\u53e6\u4e00\u500b\u95dc\u9375\u9a45\u52d5\u56e0\u7d20\uff0c\u5176\u4f5c\u7528\u6709\u671b\u8207\u964d\u4f4e\u7a81\u8b8a HTT \u6240\u5e36\u4f86\u7684\u76ca\u8655\u76f8\u8f14\u76f8\u6210\u3002 Skyhawk \u4eca\u5929\u4e5f\u5ba3\u4f48\uff0c\u5176\u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d\u7684 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u958b\u5c55\u7684 SKY-0515 \u7b2c 2\/3 \u671f FALCON-HD \u8a66\u9a57\u5df2\u64f4\u5c55\u5230\u5168\u7403\u3002 Skyhawk \u76ee\u524d\u5df2\u8b93\u8d85\u904e 90\u540d\u60a3\u8005\u670d\u7528 SKY-0515\u3002\u00a0 SKY-0515 \u662f Skyhawk \u9996\u7a2e\u63a5\u53d7\u81e8\u5e8a\u8a66\u9a57\u7684\u85e5\u7269\u3002 Skyhawk \u9810\u8a08\u5230 2027 \u5e74\u5e95\uff0c\u5c07\u63a8\u52d5\u66f4\u591a\u7684\u5c0f\u5206\u5b50\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u8a66\u9a57\u968e\u6bb5\uff0c\u7528\u65bc\u6cbb\u7642\u76ee\u524d\u5c1a\u7121\u6838\u51c6\u75be\u75c5\u6539\u5584\u7642\u6cd5\u7684\u7f55\u898b\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002 \u95dc\u65bc SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u7814\u7a76\u00a0SKY-0515 \u7b2c 1 \u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u548c\u65e9\u671fHuntington \u75be\u75c5 (HD) \u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u7269\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002 \u8a66\u9a57\u5206\u70ba\u4e09\u90e8\u5206\u3002 A \u90e8\u5206\u548c B \u90e8\u5206\u8a55\u4f30 SKY-0515 \u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684\u8868\u73fe\u3002 C \u90e8\u5206\u662f\u4e00\u9805\u96d9\u76f2\u5b89\u6170\u5291\u5c0d\u7167\u5e73\u884c\u8a2d\u8a08\u7814\u7a76\uff0c\u7814\u7a76 SKY-0515 \u7684\u5169\u7a2e\u5291\u91cf\u6c34\u5e73\u548c\u5b89\u6170\u5291\u5c0d\u65e9\u671f HD\uff08HD-ISS 1 \u671f\u30012 \u671f\u6216\u8f15\u5ea6 3 \u671f\uff09\u60a3\u8005\u9032\u884c 84 \u5929\u7684\u6cbb\u7642\uff0c\u96a8\u5f8c\u9032\u884c 12 \u500b\u6708\u7684\u6d3b\u6027\u6cbb\u7642\u5ef6\u9577\uff0c\u6240\u6709\u53c3\u8207\u8005\u5c07\u4ee5\u76f2\u6cd5\u63a5\u53d7\u4f4e\u5291\u91cf\u6216\u9ad8\u5291\u91cf\u7684 SKY-0515\u3002 \u7814\u7a76\u7684\u76ee\u6a19\u5305\u62ec\u8a55\u4f30\u7a81\u8b8a\u578b HTT \u86cb\u767d\u548c PMS1 mRNA\u3002 SKY-0515 C \u90e8\u5206\u7684\u9996\u6279\u60a3\u8005\u65bc 2025 \u5e74 1 \u6708\u63a5\u53d7\u85e5\u7269\u3002 \u73fe\u5df2\u5b8c\u6210\u62db\u52df SKY-0515 \u8a66\u9a57\u7b2c 1C \u671f\u53d7\u8a66\u8005\u3002 \u95dc\u65bc SKY-0515 \u7684\u7b2c 2\/3 \u671f FALCON-HD \u81e8\u5e8a\u7814\u7a76\u00a0 FALCON-HD\u00a0(NCT06873334) \u662f\u4e00\u9805\u7b2c 2\/3 \u671f\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u5291\u91cf\u7bc4\u570d\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30 SKY-0515 \u5728\u6fb3\u6d32\u548c\u7d10\u897f\u862d 12 \u500b\u7814\u7a76\u4e2d\u5fc3\u7684 120 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\uff0c\u4ee5\u53ca\u5168\u7403 40 \u591a\u500b\u7814\u7a76\u4e2d\u5fc3\u7684 400 \u540d 2 \u671f\u548c\u65e9\u671f 3 \u671f HD \u60a3\u8005\u4e2d\u7684\u85e5\u6548\u5b78\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u5c07\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d SKY-0515\uff08\u4e09\u7a2e\u5291\u91cf\u6c34\u5e73\u4e4b\u4e00\uff09\u6216\u5b89\u6170\u5291\uff0c\u6cbb\u7642\u671f\u81f3\u5c11\u70ba 12 \u500b\u6708\u3002 \u8a66\u9a57\u65e8\u5728\u8a55\u4f30 SKY-0515 \u8abf\u7bc0 RNA \u62fc\u63a5\u548c\u6e1b\u5c11 mHTT \u548c PMS1 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\u60a3\u8005\u7522\u751f\u6709\u610f\u7fa9\u7684\u5f71\u97ff\u3002\u5c0d\u65bc\u4ed6\u5011\u4f86\u8aaa\uff0c\u50cf SKY-0515 \u9019\u6a23\u7684\u53e3\u670d Huntington \u964d\u4f4e\u6cbb\u7642\u5c07\u771f\u6b63\u5177\u6709\u8b8a\u9769\u6027\u610f\u7fa9\u3002\u300d Skyhawk Therapeutics \u7814\u767c\u4e3b\u7ba1 Sergey Paushkin \u8868\u793a\uff1a\u300c\u6211\u5011\u9032\u884c\u7b2c I \u671f\u7814\u7a76\u7684\u76ee\u6a19\u662f\u78ba\u5b9a SKY-0515 \u7684\u5b89\u5168\u6027\u548c\u751f\u7269\u6a19\u8a18\u6d3b\u6027\u3002\u800c\u5176\u751f\u7269\u6a19\u8a18\u53cd\u61c9\u5728\u6211\u5011\u4e5d\u500b\u6708\u7684\u4e2d\u671f\u6578\u64da\u5206\u6790\u4e2d\u6301\u7e8c\u5f37\u52c1\uff0c\u4e26\u4e14\u8207\u60a3\u8005\u81ea\u7136\u75c5\u7a0b\u6578\u64da\u4e2d cUHDRS \u8a55\u5206\u7684\u60e1\u5316\u76f8\u6bd4\uff0c\u6f5b\u5728\u7d42\u9ede cUHDRS \u6709\u6240\u6539\u5584\uff0c\u9019\u5f70\u986f\u4e86 SKY-0515 \u4f5c\u70ba HD \u6700\u4f73\u75be\u75c5\u4fee\u98fe\u7642\u6cd5\u7684\u6f5b\u529b\u3002 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