{"id":391294,"date":"2025-12-10T17:15:00","date_gmt":"2025-12-10T09:15:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=391294"},"modified":"2025-12-10T17:15:00","modified_gmt":"2025-12-10T09:15:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%90%8c%e9%a1%9e%e9%a6%96%e5%89%b5fasn%e6%8a%91%e5%88%b6%e5%8a%91%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%88asc40%ef%bc%89%e6%b2%bb%e7%99%82%e7%97%a4","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=391294","title":{"rendered":"\u6b4c\u79ae\u5ba3\u4f48\u540c\u985e\u9996\u5275FASN\u6291\u5236\u5291\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u6cbb\u7642\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u53d7\u7406"},"content":{"rendered":"
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–<\/i>\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684<\/i>III<\/i>\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08<\/i>ASC40<\/i>\uff09\u9054\u5230\u6240\u6709\u4e3b\u8981\u3001\u95dc\u9375\u6b21\u8981\u53ca\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff08\u610f\u5411\u6cbb\u7642\u96c6\uff08<\/i>ITT<\/i>\uff09\u5206\u6790\uff09\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\u986f\u8457\u6539\u5584\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2025\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u3001\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u5c0f\u5206\u5b50\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u6cbb\u7642\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08\u570b\u5bb6\u85e5\u76e3\u5c40\uff09\u53d7\u7406\u3002<\/p>\n

\u300c\u6b64NDA\u7372\u53d7\u7406\u662f\u6211\u5011\u5728\u70ba\u4e2d\u91cd\u5ea6\u75e4\u7621\u6cbb\u7642\u63d0\u4f9b\u6f5b\u5728\u958b\u5275\u6027\u7642\u6cd5\u7684\u9053\u8def\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u96e2\u5546\u696d\u5316\u50c5\u4e00\u6b65\u4e4b\u9059\uff0c\u9019\u4ee4\u6211\u5011\u611f\u5230\u632f\u596e\u3002\u300d<\/p>\n

\u6b4c\u79ae\u5df2\u5b8c\u6210\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u6cbb\u7642\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684II\u671f\uff08NCT05104125<\/a>\uff09\u548cIII\u671f\uff08NCT06192264<\/a>\uff09\u7814\u7a76\u3002<\/p>\n

\u5728\u8a72III\u671f\u7814\u7a76\u4e2d\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u9054\u5230\u6240\u6709\u4e3b\u8981\u3001\u95dc\u9375\u6b21\u8981\u53ca\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff08\u610f\u5411\u6cbb\u7642\u96c6\uff08ITT\uff09\u5206\u6790\uff09\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\u986f\u8457\u6539\u5584\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u3002\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u7279\u5fb5\u3002\u6240\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u6cbb\u7642\u671f\u9593\u767c\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08treatment-emergent adverse events\uff0cTEAE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\u3002\u6c92\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u76843\u7d1a\u62164\u7d1aTEAE\uff0c\u4e14\u6c92\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u672a\u6709\u89c0\u5bdf\u5230\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u6c38\u4e45\u6027\u7d42\u6b62\u6cbb\u7642\u6216\u9000\u51fa\u8a66\u9a57\u7684\u60c5\u6cc1\u3002<\/p>\n

2025\u5e749\u670817\u65e5\uff0c\u5728\u6cd5\u570b\u5df4\u9ece\u8209\u8fa6\u76842025\u5e74\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff09\u5e74\u6703\u4e0a\uff0c\u6b4c\u79ae\u53e3\u982d\u5831\u544a\u4e86\u8a72\u9805III\u671f\u7814\u7a76\u7d50\u679c\uff08\u93c8\u63a5<\/a>\uff09\u3002<\/p>\n

\u672c\u516c\u53f8\u5df2\u65bc\u8fd1\u671f\u5b8c\u6210\u8207\u4e2d\u570b\u570b\u5bb6\u85e5\u76e3\u5c40\u5c31\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08denifanstat\uff0cASC40\uff09\u6cbb\u7642\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u524d\uff08Pre-NDA\uff09\u6e9d\u901a\u4e26\u6536\u5230\u570b\u5bb6\u85e5\u76e3\u5c40\u7684\u7a4d\u6975\u53cd\u994b\u3002<\/span><\/p>\n

\u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aSGMT\uff09\u7372\u5f97\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u7684\u5927\u4e2d\u83ef\u5340\u7368\u5bb6\u6388\u6b0a\u3002<\/p>\n

\u95dc<\/b>\u65bc\u6b4c<\/b>\u79ae<\/b>\u5236<\/b>\u85e5<\/b>\u6709\u9650\u516c\u53f8<\/b><\/p>\n

\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3e\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002<\/p>\n

\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com<\/a>\u3002<\/p>\n

\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

Peter Vozzo<\/span>
ICR Healthcare
443-231-0505 (\u7f8e\u570b)
Peter.vozzo@icrhealthcare.com<\/a><\/p>\n

\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a
+86-181-0650-9129 (\u4e2d\u570b)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

–\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2…<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-391294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u6b4c\u79ae\u5ba3\u4f48\u540c\u985e\u9996\u5275FASN\u6291\u5236\u5291\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u6cbb\u7642\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u53d7\u7406 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" 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events\uff0cTEAE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\u3002\u6c92\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u76843\u7d1a\u62164\u7d1aTEAE\uff0c\u4e14\u6c92\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u672a\u6709\u89c0\u5bdf\u5230\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u6c38\u4e45\u6027\u7d42\u6b62\u6cbb\u7642\u6216\u9000\u51fa\u8a66\u9a57\u7684\u60c5\u6cc1\u3002 2025\u5e749\u670817\u65e5\uff0c\u5728\u6cd5\u570b\u5df4\u9ece\u8209\u8fa6\u76842025\u5e74\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff09\u5e74\u6703\u4e0a\uff0c\u6b4c\u79ae\u53e3\u982d\u5831\u544a\u4e86\u8a72\u9805III\u671f\u7814\u7a76\u7d50\u679c\uff08\u93c8\u63a5\uff09\u3002 \u672c\u516c\u53f8\u5df2\u65bc\u8fd1\u671f\u5b8c\u6210\u8207\u4e2d\u570b\u570b\u5bb6\u85e5\u76e3\u5c40\u5c31\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08denifanstat\uff0cASC40\uff09\u6cbb\u7642\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u524d\uff08Pre-NDA\uff09\u6e9d\u901a\u4e26\u6536\u5230\u570b\u5bb6\u85e5\u76e3\u5c40\u7684\u7a4d\u6975\u53cd\u994b\u3002 \u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aSGMT\uff09\u7372\u5f97\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u7684\u5927\u4e2d\u83ef\u5340\u7368\u5bb6\u6388\u6b0a\u3002 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement Technology\uff0cPOTENT\uff09\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5c0f\u5206\u5b50\u548c\u591a\u80bd\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76eeASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\uff1bASC36\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC35\uff0c\u4e00\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0cASC37\uff0c\u4e00\u6b3e\u53e3\u670dGLP-1R\/GIPR\/GCGR\u4e09\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=391294\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u5ba3\u4f48\u540c\u985e\u9996\u5275FASN\u6291\u5236\u5291\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u6cbb\u7642\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u53d7\u7406 - 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\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u3001\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u5c0f\u5206\u5b50\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5291\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u6cbb\u7642\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08\u570b\u5bb6\u85e5\u76e3\u5c40\uff09\u53d7\u7406\u3002 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\u5728\u8a72III\u671f\u7814\u7a76\u4e2d\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u9054\u5230\u6240\u6709\u4e3b\u8981\u3001\u95dc\u9375\u6b21\u8981\u53ca\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff08\u610f\u5411\u6cbb\u7642\u96c6\uff08ITT\uff09\u5206\u6790\uff09\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\u986f\u8457\u6539\u5584\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u3002\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u7279\u5fb5\u3002\u6240\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u6cbb\u7642\u671f\u9593\u767c\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08treatment-emergent adverse events\uff0cTEAE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\u3002\u6c92\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u76843\u7d1a\u62164\u7d1aTEAE\uff0c\u4e14\u6c92\u6709\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u672a\u6709\u89c0\u5bdf\u5230\u8207\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u76f8\u95dc\u7684\u6c38\u4e45\u6027\u7d42\u6b62\u6cbb\u7642\u6216\u9000\u51fa\u8a66\u9a57\u7684\u60c5\u6cc1\u3002 2025\u5e749\u670817\u65e5\uff0c\u5728\u6cd5\u570b\u5df4\u9ece\u8209\u8fa6\u76842025\u5e74\u6b50\u6d32\u76ae\u819a\u75c5\u8207\u6027\u75c5\u5b78\u6703\uff08EADV\uff09\u5e74\u6703\u4e0a\uff0c\u6b4c\u79ae\u53e3\u982d\u5831\u544a\u4e86\u8a72\u9805III\u671f\u7814\u7a76\u7d50\u679c\uff08\u93c8\u63a5\uff09\u3002 \u672c\u516c\u53f8\u5df2\u65bc\u8fd1\u671f\u5b8c\u6210\u8207\u4e2d\u570b\u570b\u5bb6\u85e5\u76e3\u5c40\u5c31\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08denifanstat\uff0cASC40\uff09\u6cbb\u7642\u4e2d\u91cd\u5ea6\u5c0b\u5e38\u6027\u75e4\u7621\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u524d\uff08Pre-NDA\uff09\u6e9d\u901a\u4e26\u6536\u5230\u570b\u5bb6\u85e5\u76e3\u5c40\u7684\u7a4d\u6975\u53cd\u994b\u3002 \u6b4c\u79ae\u5df2\u5f9eSagimet Biosciences Inc.\uff08\u7d0d\u65af\u9054\u514b\u80a1\u7968\u4ee3\u78bc\uff1aSGMT\uff09\u7372\u5f97\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff08ASC40\uff09\u7684\u5927\u4e2d\u83ef\u5340\u7368\u5bb6\u6388\u6b0a\u3002 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u3001\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u4ee5\u53ca\u53e3\u670d\u591a\u80bd\u905e\u9001\u589e\u5f37\u6280\u8853\uff08Peptide Oral Transport ENhancement 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