{"id":390740,"date":"2025-12-09T09:59:00","date_gmt":"2025-12-09T01:59:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=390740"},"modified":"2025-12-09T09:59:00","modified_gmt":"2025-12-09T01:59:00","slug":"%e3%80%90%e7%9b%b4%e6%93%8a2025-ash%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5%e8%80%90%e7%ab%8b%e5%85%8b%e6%b2%bb%e7%99%82tki%e8%80%90%e8%97%a5-%e4%b8%8d%e8%80%90%e5%8f%97cml-cp%e6%82%a3","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=390740","title":{"rendered":"\u3010\u76f4\u64ca2025 ASH\u3011\u4e9e\u76db\u91ab\u85e5\u8010\u7acb\u514b\u00ae\u6cbb\u7642TKI\u8010\u85e5\/\u4e0d\u8010\u53d7CML-CP\u60a3\u8005\u7684\u8a3b\u518aII\u671f\u7814\u7a764\u5e74\u96a8\u8a2a\u6578\u64da\u4eae\u76f8\uff0c\u9577\u671f\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\u518d\u7372\u8b49\u5be6"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • \u8010\u7acb\u514b<\/i>\u00ae<\/sup><\/i>\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4d\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08<\/i>EFS<\/i>\uff09\u70ba<\/i>21.2<\/i>\u500b\u6708\uff0c\u660e\u986f\u512a\u65bc\u5c0d\u7167\u7d44\u7684<\/i>2.9<\/i>\u500b\u6708<\/i><\/li>\n
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    \n<\/p><\/div>\n

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    Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations
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    \u6838\u5fc3\u8981\u9ede<\/b>\uff1a<\/span>
    \u7814\u7a76\u80cc\u666f<\/u>\uff1a
    CML\u00a0\u662f\u4e00\u7a2e\u7372\u5f97\u6027\u9020\u8840\u5e72\u7d30\u80de\u60e1\u6027\u514b\u9686\u6027\u75be\u75c5\uff0cTKI\u7684\u51fa\u73fe\u4f7fCML\u60a3\u8005\u7684\u6cbb\u7642\u5fb9\u5e95\u6539\u89c0\u4f46\u4ecd\u6709\u76f8\u7576\u6bd4\u4f8b\u7684\u60a3\u8005\u5728\u6cbb\u7642\u4e2d\u51fa\u73fe\u8010\u85e5\u6216\u56e0\u5b89\u5168\u6027\u4e0d\u8010\u53d7\u505c\u85e5\uff0c\u9032\u800c\u9762\u81e8\u66f4\u70ba\u56b4\u91cd\u7684\u5f8c\u679c\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u5c0d\u4e00\u4ee3\u4e8c\u4ee3TKI\u00a0\u5747\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CML\u00a0\u60a3\u8005\uff0c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u4e14\u8a72\u985e\u60a3\u8005\u6709\u8457\u660e\u78ba\u75c5\u60c5\u9032\u5c55\u7684\u98a8\u96aa\u3002\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u7a2e\u5f37\u6548\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5c0d\u651c\u5e36\u91ce\u751f\u578bBCR-ABL\u7684CML\u548c\u651c\u5e36BCR-ABL-T315I\u7a81\u8b8a\uff08\u53ef\u5c0e\u81f4\u5c0d\u65bc\u4f0a\u99ac\u66ff\u5c3c\u548c\u7b2c\u4e8c\u4ee3TKI\u8010\u85e5\uff09\u7684CML\u60a3\u8005\u5747\u6709\u8f03\u5f37\u7642\u6548\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002<\/p>\n

    \u7814\u7a76\u4ecb\u7d39<\/u>\uff1a<\/p>\n

      \n
    • \u8a72\u7814\u7a76\uff08NCT04126681\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u95dc\u9375\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u5747\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u672c\u5831\u544a\u70ba\u4e00\u98052023ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u7684\u7814\u7a76\u66f4\u65b0\u6578\u64da\u3002\u622a\u81f32025\u5e741\u670813\u65e5\uff0c\u5171\u6709144\u4f8bCML-CP\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d105\u4f8b\u70ba\u4e0d\u4f34T315I\u7a81\u8b8a\u60a3\u8005\u3002<\/li>\n
    • \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u88ab\u6309\u71672:1 \u6bd4\u4f8b\u96a8\u6a5f\u5206\u7d44\u9032\u5165\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548c\u7814\u7a76\u8005\u6c7a\u5b9a\u7684BAT\u5c0d\u7167\u7d44\u3002<\/li>\n
    • \u4e3b\u8981\u7d42\u9ede\u70ba\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u3002\u4e8b\u4ef6\u7684\u5b9a\u7fa9\u70ba\uff1a\u75be\u75c5\u9032\u5c55\u3001\u9054\u5230\u53c8\u6d88\u5931\u7684\u5b8c\u5168\u8840\u6db2\u5b78\u7de9\u89e3\uff08CHR\uff09\u3001\u4e3b\u8981\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\u3001\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\uff1b\u6cbb\u7642\u5931\u6557\uff1b3\u500b\u6cbb\u7642\u9031\u671f\u5167\u672a\u9054CHR\uff1b\u4efb\u4f55\u539f\u56e0\u5c0e\u81f4\u7684\u6b7b\u4ea1\uff1b\u4e0d\u53ef\u63a5\u53d7\u7684\u85e5\u7269\u6bd2\u6027\u3002<\/li>\n<\/ul>\n

      \u7642\u6548\u6578\u64da<\/u>\uff1a<\/p>\n

        \n
      • \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u986f\u8457\u9577\u65bcBAT\u6cbb\u7642\u7d44\uff1a\u5728\u6240\u6709CMP-CP\u60a3\u8005\u4e2d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548cBAT\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u5206\u5225\u70ba21.2\u500b\u6708\u548c2.9\u500b\u6708\uff08P <\/i>< 0.0001\uff09\uff1b\u5728\u4e0d\u4f34T315I\u7a81\u8b8aCML-CP\u60a3\u8005\u4e2d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548cBAT\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u5206\u5225\u70ba11.9 \u548c3.1\u500b\u6708\uff08P<\/i> = 0.0159\uff09\u3002<\/li>\n
      • \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u7684\u5176\u4ed6\u7642\u6548\u6307\u6a19\u986f\u8457\u9ad8\u65bcBAT\u6cbb\u7642\u7d44\uff1a\u5728\u6240\u6709CML-CP\u60a3\u8005\u4e2d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548cBAT\u6cbb\u7642\u7d44\u7684CHR\u7387\u5206\u5225\u70ba85% \u548c35%\uff0c CCyR\u7387\u5206\u5225\u70ba38%\u548c19%\uff0c\u4e3b\u8981\u5206\u5b50\u5b78\u53cd\u61c9\uff08MMR\uff09\u7387\u5206\u5225\u70ba30%\u548c8%\uff1b\u5728\u4e0d\u4f34T315I\u7a81\u8b8aCML-CP\u60a3\u8005\u4e2d\uff0cCHR\u7387\u5206\u5225\u70ba82% \u548c50%\uff0cCCyR\u7387\u5206\u5225\u70ba26%\u548c21%\uff0cMMR\u7387\u5206\u5225\u70ba16%\u548c10%\u3002<\/li>\n<\/ul>\n

        \u5b89\u5168\u6027\u6578\u64da<\/u>\uff1a\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u5728\u4f34\u6216\u4e0d\u4f34T315I\u7a81\u8b8a\u7684CML-CP\u60a3\u8005\u4e2d\u5747\u5c55\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4e14\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u22653\u7d1a\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u70ba\u8840\u6db2\u6bd2\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u7684\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7%\u3002<\/p>\n

        \u7d50\u8ad6<\/u>\uff1a\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u5747\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u53d7\u8a66\u8005\uff0c\u5305\u62ec\u4e0d\u4f34T315I\u7a81\u8b8aCML-CP\u60a3\u8005\u6642\uff0c\u8f03BAT\u6cbb\u7642\u7d44\u5c55\u793a\u51fa\u660e\u986f\u6cbb\u7642\u512a\u52e2\u3002<\/p>\n

        \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/b><\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002<\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002<\/p>\n

        \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae<\/sup><\/i>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae<\/sup><\/i>\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae<\/sup><\/i>\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002<\/p>\n

        \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae<\/sup><\/i>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae<\/sup><\/i>\u56db\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002<\/p>\n

        \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002<\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

        \u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n

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\u6b64\u9805\u7814\u7a76\u7684\u5831\u544a\u4eba\u3001\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u6c5f\u5029\u6559\u6388\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6578\u64da\uff0c\u518d\u6b21\u9a57\u8b49\u4e86\u8010\u7acb\u514b\u00ae\u5728TKI\u8010\u85e5\/\u4e0d\u8010\u53d7CML-CP\u60a3\u8005\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u4eba\u7fa4\u4e2d\u7684\u5353\u8d8a\u7642\u6548\uff0c\u8868\u73fe\u51fa\u7684\u9577\u671f\u5b89\u5168\u6027\u7279\u5fb5\u2014\u2014\u7279\u5225\u662f\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7%\uff0c\u70ba\u81e8\u5e8a\u91ab\u751f\u8207\u60a3\u8005\u63d0\u4f9b\u4e86\u81f3\u95dc\u91cd\u8981\u7684\u9577\u671f\u7528\u85e5\u4fe1\u5fc3\u3002\u9019\u4e9b\u6578\u64da\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u8a72\u85e5\u5728\u81e8\u5e8a\u5be6\u8e10\u4e2d\u7684\u91cd\u8981\u5730\u4f4d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u95dc\u9375\u7814\u7a76\u7d93\u904e4\u5e74\u96a8\u8a2a\uff0c\u5176\u6578\u64da\u7684\u6301\u7e8c\u6210\u719f\u8b93\u6211\u5011\u500d\u611f\u9f13\u821e\u3002\u5b83\u4e0d\u50c5\u8b49\u5be6\u4e86\u85e5\u7269\u7684\u6301\u4e45\u7642\u6548\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5c55\u73fe\u4e86\u51fa\u8272\u7684\u9577\u671f\u5b89\u5168\u6027\uff0c\u9019\u76f4\u63a5\u95dc\u4e4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\u8207\u9577\u671f\u7372\u76ca\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u8a3b\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a3788\u5206\u6703\u5834\uff1a632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0b\u534818:00 \u2013 20:00\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67088\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0a\u53487:00 \u2013 9:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\uff0c\u6c5f\u5029\u6559\u6388\u5831\u544a\u4eba\uff1a\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\uff0c\u6c5f\u5029\u6559\u6388\u00a0\u6838\u5fc3\u8981\u9ede\uff1a\u7814\u7a76\u80cc\u666f\uff1aCML\u00a0\u662f\u4e00\u7a2e\u7372\u5f97\u6027\u9020\u8840\u5e72\u7d30\u80de\u60e1\u6027\u514b\u9686\u6027\u75be\u75c5\uff0cTKI\u7684\u51fa\u73fe\u4f7fCML\u60a3\u8005\u7684\u6cbb\u7642\u5fb9\u5e95\u6539\u89c0\u4f46\u4ecd\u6709\u76f8\u7576\u6bd4\u4f8b\u7684\u60a3\u8005\u5728\u6cbb\u7642\u4e2d\u51fa\u73fe\u8010\u85e5\u6216\u56e0\u5b89\u5168\u6027\u4e0d\u8010\u53d7\u505c\u85e5\uff0c\u9032\u800c\u9762\u81e8\u66f4\u70ba\u56b4\u91cd\u7684\u5f8c\u679c\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u5c0d\u4e00\u4ee3\u4e8c\u4ee3TKI\u00a0\u5747\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CML\u00a0\u60a3\u8005\uff0c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u4e14\u8a72\u985e\u60a3\u8005\u6709\u8457\u660e\u78ba\u75c5\u60c5\u9032\u5c55\u7684\u98a8\u96aa\u3002\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u7a2e\u5f37\u6548\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5c0d\u651c\u5e36\u91ce\u751f\u578bBCR-ABL\u7684CML\u548c\u651c\u5e36BCR-ABL-T315I\u7a81\u8b8a\uff08\u53ef\u5c0e\u81f4\u5c0d\u65bc\u4f0a\u99ac\u66ff\u5c3c\u548c\u7b2c\u4e8c\u4ee3TKI\u8010\u85e5\uff09\u7684CML\u60a3\u8005\u5747\u6709\u8f03\u5f37\u7642\u6548\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a \u8a72\u7814\u7a76\uff08NCT04126681\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u95dc\u9375\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u5747\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u672c\u5831\u544a\u70ba\u4e00\u98052023ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u7684\u7814\u7a76\u66f4\u65b0\u6578\u64da\u3002\u622a\u81f32025\u5e741\u670813\u65e5\uff0c\u5171\u6709144\u4f8bCML-CP\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d105\u4f8b\u70ba\u4e0d\u4f34T315I\u7a81\u8b8a\u60a3\u8005\u3002 \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u88ab\u6309\u71672:1 \u6bd4\u4f8b\u96a8\u6a5f\u5206\u7d44\u9032\u5165\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548c\u7814\u7a76\u8005\u6c7a\u5b9a\u7684BAT\u5c0d\u7167\u7d44\u3002 \u4e3b\u8981\u7d42\u9ede\u70ba\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u3002\u4e8b\u4ef6\u7684\u5b9a\u7fa9\u70ba\uff1a\u75be\u75c5\u9032\u5c55\u3001\u9054\u5230\u53c8\u6d88\u5931\u7684\u5b8c\u5168\u8840\u6db2\u5b78\u7de9\u89e3\uff08CHR\uff09\u3001\u4e3b\u8981\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\u3001\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\uff1b\u6cbb\u7642\u5931\u6557\uff1b3\u500b\u6cbb\u7642\u9031\u671f\u5167\u672a\u9054CHR\uff1b\u4efb\u4f55\u539f\u56e0\u5c0e\u81f4\u7684\u6b7b\u4ea1\uff1b\u4e0d\u53ef\u63a5\u53d7\u7684\u85e5\u7269\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u986f\u8457\u9577\u65bcBAT\u6cbb\u7642\u7d44\uff1a\u5728\u6240\u6709CMP-CP\u60a3\u8005\u4e2d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548cBAT\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u5206\u5225\u70ba21.2\u500b\u6708\u548c2.9\u500b\u6708\uff08P < 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content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u64ca2025 ASH\u3011\u4e9e\u76db\u91ab\u85e5\u8010\u7acb\u514b\u00ae\u6cbb\u7642TKI\u8010\u85e5\/\u4e0d\u8010\u53d7CML-CP\u60a3\u8005\u7684\u8a3b\u518aII\u671f\u7814\u7a764\u5e74\u96a8\u8a2a\u6578\u64da\u4eae\u76f8\uff0c\u9577\u671f\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\u518d\u7372\u8b49\u5be6 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4d\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u70ba21.2\u500b\u6708\uff0c\u660e\u986f\u512a\u65bc\u5c0d\u7167\u7d44\u76842.9\u500b\u6708 \u8010\u7acb\u514b\u00ae\u986f\u793a\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7% 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Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u5176\u6838\u5fc3\u7522\u54c1\u5967\u96f7\u5df4\u66ff\u5c3c\uff08\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u6cbb\u7642\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\/\u4e0d\u8010\u53d7\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff08CML\uff09-\u6162\u6027\u671f\uff08CP\uff09\u60a3\u8005\u7684\u96a8\u6a5f\u5c0d\u7167\u8a3b\u518aII\u671f\u7814\u7a76\u76844\u5e74\u96a8\u8a2a\u6578\u64da\u3002\u9019\u662f\u5c0d\u8a72\u7814\u7a76\u57282023ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u7814\u7a76\u7d50\u679c\u7684\u6301\u7e8c\u66f4\u65b0\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u4e86\u8010\u7acb\u514b\u00ae\u7684\u9577\u671f\u7642\u6548\u8207\u5b89\u5168\u6027\u512a\u52e2\u3002 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ALL\uff09\u3001\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u5e7e\u5927\u9069\u61c9\u75c7\u3002\u6b64\u5916\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u7d93\u8207\u8de8\u570b\u88fd\u85e5\u4f01\u696d\u6b66\u7530\u5c31\u8010\u7acb\u514b\u00ae\u7c3d\u7f72\u4e86\u4e00\u9805\u7368\u5bb6\u9078\u64c7\u6b0a\u4e8b\u5b9c\u3002\u4e00\u65e6\u884c\u4f7f\u9078\u64c7\u6b0a\uff0c\u6b66\u7530\u5c07\u7372\u5f97\u958b\u767c\u53ca\u5546\u696d\u5316\u8010\u7acb\u514b\u00ae\u7684\u5168\u7403\u6b0a\u5229\u8a31\u53ef\uff0c\u60df\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u53f0\u7063\u7b49\u5730\u5340\u9664\u5916\u3002 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\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u95dc\u9375\u7814\u7a76\u7d93\u904e4\u5e74\u96a8\u8a2a\uff0c\u5176\u6578\u64da\u7684\u6301\u7e8c\u6210\u719f\u8b93\u6211\u5011\u500d\u611f\u9f13\u821e\u3002\u5b83\u4e0d\u50c5\u8b49\u5be6\u4e86\u85e5\u7269\u7684\u6301\u4e45\u7642\u6548\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5c55\u73fe\u4e86\u51fa\u8272\u7684\u9577\u671f\u5b89\u5168\u6027\uff0c\u9019\u76f4\u63a5\u95dc\u4e4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\u8207\u9577\u671f\u7372\u76ca\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u8a3b\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a3788\u5206\u6703\u5834\uff1a632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0b\u534818:00 \u2013 20:00\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67088\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0a\u53487:00 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\u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u8a3b\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a3788\u5206\u6703\u5834\uff1a632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0b\u534818:00 \u2013 20:00\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67088\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0a\u53487:00 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\u6b64\u6b21\u5c55\u793a\u76844\u5e74\u96a8\u8a2a\u6578\u64da\u986f\u793a\uff0c\u8010\u7acb\u514b\u00ae\u5728TKI\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CML-CP\uff08\u5305\u62ec\u4e0d\u4f34T315I\u7a81\u8b8a\uff09\u60a3\u8005\u4e2d\uff0c\u6301\u7e8c\u5c55\u73fe\u51fa\u512a\u65bc\u7814\u7a76\u8005\u6c7a\u5b9a\u7684\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\u7684\u986f\u8457\u7642\u6548\u3002\u5728\u6240\u6709CML-CP\u60a3\u8005\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4d\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u9054\u523021.2\u500b\u6708\uff0c\u986f\u8457\u512a\u65bcBAT\u7d44\u76842.9\u500b\u6708\uff1b\u5728\u4e0d\u4f34T315I\u7a81\u8b8aCML-CP\u60a3\u8005\u4e2d\uff0c\u8010\u7acb\u514b\u00ae\u6cbb\u7642\u7d44\u7684EFS\u70ba11.9\u500b\u6708\uff0c\u986f\u8457\u512a\u65bcBAT\u7d44\u76843.1\u500b\u6708\u3002\u503c\u5f97\u95dc\u6ce8\u7684\u662f\uff0c\u9577\u671f\u96a8\u8a2a\u6578\u64da\u8b49\u5be6\u5176\u5b89\u5168\u6027\u826f\u597d\uff0c\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7%\u3002 \u8010\u7acb\u514b\u00ae\u662f\u4e9e\u76db\u91ab\u85e5\u539f\u52751\u985e\u65b0\u85e5\uff0c\u70ba\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\u3002\u5176\u5728\u4e2d\u570b\u7684\u5546\u696d\u5316\u63a8\u5ee3\u7531\u4e9e\u76db\u91ab\u85e5\u548c\u4fe1\u9054\u751f\u7269\u5171\u540c\u8ca0\u8cac\u3002\u76ee\u524d\uff0c\u8010\u7acb\u514b\u00ae\u5df2\u5728\u4e2d\u570b\u7372\u6279\u7684\u9069\u61c9\u75c7\u70ba\uff1a\u6cbb\u7642\u4efb\u4f55TKI\u8010\u85e5\u3001\u4e26\u4f34\u6709T315I\u7a81\u8b8a\u7684CML-CP\u548c\u52a0\u901f\u671f\uff08-AP\uff09\u7684\u6210\u5e74\u60a3\u8005\uff1b\u4ee5\u53ca\u6cbb\u7642\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u6210\u5e74\u60a3\u8005\uff0c\u4e14\u6240\u6709\u7372\u6279\u9069\u61c9\u75c7\u5747\u5df2\u88ab\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e09\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u6d89\u53caCML-CP\u3001\u65b0\u8a3a\u65b7\u7684\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u3001\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u5e7e\u5927\u9069\u61c9\u75c7\u3002\u6b64\u5916\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u7d93\u8207\u8de8\u570b\u88fd\u85e5\u4f01\u696d\u6b66\u7530\u5c31\u8010\u7acb\u514b\u00ae\u7c3d\u7f72\u4e86\u4e00\u9805\u7368\u5bb6\u9078\u64c7\u6b0a\u4e8b\u5b9c\u3002\u4e00\u65e6\u884c\u4f7f\u9078\u64c7\u6b0a\uff0c\u6b66\u7530\u5c07\u7372\u5f97\u958b\u767c\u53ca\u5546\u696d\u5316\u8010\u7acb\u514b\u00ae\u7684\u5168\u7403\u6b0a\u5229\u8a31\u53ef\uff0c\u60df\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u53f0\u7063\u7b49\u5730\u5340\u9664\u5916\u3002 \u6b64\u9805\u7814\u7a76\u7684\u5831\u544a\u4eba\u3001\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u6c5f\u5029\u6559\u6388\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6578\u64da\uff0c\u518d\u6b21\u9a57\u8b49\u4e86\u8010\u7acb\u514b\u00ae\u5728TKI\u8010\u85e5\/\u4e0d\u8010\u53d7CML-CP\u60a3\u8005\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u4eba\u7fa4\u4e2d\u7684\u5353\u8d8a\u7642\u6548\uff0c\u8868\u73fe\u51fa\u7684\u9577\u671f\u5b89\u5168\u6027\u7279\u5fb5\u2014\u2014\u7279\u5225\u662f\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7%\uff0c\u70ba\u81e8\u5e8a\u91ab\u751f\u8207\u60a3\u8005\u63d0\u4f9b\u4e86\u81f3\u95dc\u91cd\u8981\u7684\u9577\u671f\u7528\u85e5\u4fe1\u5fc3\u3002\u9019\u4e9b\u6578\u64da\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u8a72\u85e5\u5728\u81e8\u5e8a\u5be6\u8e10\u4e2d\u7684\u91cd\u8981\u5730\u4f4d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u95dc\u9375\u7814\u7a76\u7d93\u904e4\u5e74\u96a8\u8a2a\uff0c\u5176\u6578\u64da\u7684\u6301\u7e8c\u6210\u719f\u8b93\u6211\u5011\u500d\u611f\u9f13\u821e\u3002\u5b83\u4e0d\u50c5\u8b49\u5be6\u4e86\u85e5\u7269\u7684\u6301\u4e45\u7642\u6548\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5c55\u73fe\u4e86\u51fa\u8272\u7684\u9577\u671f\u5b89\u5168\u6027\uff0c\u9019\u76f4\u63a5\u95dc\u4e4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\u8207\u9577\u671f\u7372\u76ca\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u8a3b\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a3788\u5206\u6703\u5834\uff1a632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0b\u534818:00 \u2013 20:00\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67088\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0a\u53487:00 \u2013 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ALL\uff09\u3001\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u5e7e\u5927\u9069\u61c9\u75c7\u3002\u6b64\u5916\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u7d93\u8207\u8de8\u570b\u88fd\u85e5\u4f01\u696d\u6b66\u7530\u5c31\u8010\u7acb\u514b\u00ae\u7c3d\u7f72\u4e86\u4e00\u9805\u7368\u5bb6\u9078\u64c7\u6b0a\u4e8b\u5b9c\u3002\u4e00\u65e6\u884c\u4f7f\u9078\u64c7\u6b0a\uff0c\u6b66\u7530\u5c07\u7372\u5f97\u958b\u767c\u53ca\u5546\u696d\u5316\u8010\u7acb\u514b\u00ae\u7684\u5168\u7403\u6b0a\u5229\u8a31\u53ef\uff0c\u60df\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u6fb3\u9580\u7279\u5225\u884c\u653f\u5340\u3001\u4e2d\u570b\u53f0\u7063\u7b49\u5730\u5340\u9664\u5916\u3002 \u6b64\u9805\u7814\u7a76\u7684\u5831\u544a\u4eba\u3001\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u6c5f\u5029\u6559\u6388\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6578\u64da\uff0c\u518d\u6b21\u9a57\u8b49\u4e86\u8010\u7acb\u514b\u00ae\u5728TKI\u8010\u85e5\/\u4e0d\u8010\u53d7CML-CP\u60a3\u8005\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u4eba\u7fa4\u4e2d\u7684\u5353\u8d8a\u7642\u6548\uff0c\u8868\u73fe\u51fa\u7684\u9577\u671f\u5b89\u5168\u6027\u7279\u5fb5\u2014\u2014\u7279\u5225\u662f\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7%\uff0c\u70ba\u81e8\u5e8a\u91ab\u751f\u8207\u60a3\u8005\u63d0\u4f9b\u4e86\u81f3\u95dc\u91cd\u8981\u7684\u9577\u671f\u7528\u85e5\u4fe1\u5fc3\u3002\u9019\u4e9b\u6578\u64da\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u8a72\u85e5\u5728\u81e8\u5e8a\u5be6\u8e10\u4e2d\u7684\u91cd\u8981\u5730\u4f4d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u95dc\u9375\u7814\u7a76\u7d93\u904e4\u5e74\u96a8\u8a2a\uff0c\u5176\u6578\u64da\u7684\u6301\u7e8c\u6210\u719f\u8b93\u6211\u5011\u500d\u611f\u9f13\u821e\u3002\u5b83\u4e0d\u50c5\u8b49\u5be6\u4e86\u85e5\u7269\u7684\u6301\u4e45\u7642\u6548\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5c55\u73fe\u4e86\u51fa\u8272\u7684\u9577\u671f\u5b89\u5168\u6027\uff0c\u9019\u76f4\u63a5\u95dc\u4e4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\u8207\u9577\u671f\u7372\u76ca\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u8a3b\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a3788\u5206\u6703\u5834\uff1a632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0b\u534818:00 \u2013 20:00\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67088\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0a\u53487:00 \u2013 9:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\uff0c\u6c5f\u5029\u6559\u6388\u5831\u544a\u4eba\uff1a\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\uff0c\u6c5f\u5029\u6559\u6388\u00a0\u6838\u5fc3\u8981\u9ede\uff1a\u7814\u7a76\u80cc\u666f\uff1aCML\u00a0\u662f\u4e00\u7a2e\u7372\u5f97\u6027\u9020\u8840\u5e72\u7d30\u80de\u60e1\u6027\u514b\u9686\u6027\u75be\u75c5\uff0cTKI\u7684\u51fa\u73fe\u4f7fCML\u60a3\u8005\u7684\u6cbb\u7642\u5fb9\u5e95\u6539\u89c0\u4f46\u4ecd\u6709\u76f8\u7576\u6bd4\u4f8b\u7684\u60a3\u8005\u5728\u6cbb\u7642\u4e2d\u51fa\u73fe\u8010\u85e5\u6216\u56e0\u5b89\u5168\u6027\u4e0d\u8010\u53d7\u505c\u85e5\uff0c\u9032\u800c\u9762\u81e8\u66f4\u70ba\u56b4\u91cd\u7684\u5f8c\u679c\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u5c0d\u4e00\u4ee3\u4e8c\u4ee3TKI\u00a0\u5747\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CML\u00a0\u60a3\u8005\uff0c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u4e14\u8a72\u985e\u60a3\u8005\u6709\u8457\u660e\u78ba\u75c5\u60c5\u9032\u5c55\u7684\u98a8\u96aa\u3002\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u7a2e\u5f37\u6548\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5c0d\u651c\u5e36\u91ce\u751f\u578bBCR-ABL\u7684CML\u548c\u651c\u5e36BCR-ABL-T315I\u7a81\u8b8a\uff08\u53ef\u5c0e\u81f4\u5c0d\u65bc\u4f0a\u99ac\u66ff\u5c3c\u548c\u7b2c\u4e8c\u4ee3TKI\u8010\u85e5\uff09\u7684CML\u60a3\u8005\u5747\u6709\u8f03\u5f37\u7642\u6548\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a \u8a72\u7814\u7a76\uff08NCT04126681\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u95dc\u9375\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u5747\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u672c\u5831\u544a\u70ba\u4e00\u98052023ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u7684\u7814\u7a76\u66f4\u65b0\u6578\u64da\u3002\u622a\u81f32025\u5e741\u670813\u65e5\uff0c\u5171\u6709144\u4f8bCML-CP\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d105\u4f8b\u70ba\u4e0d\u4f34T315I\u7a81\u8b8a\u60a3\u8005\u3002 \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u88ab\u6309\u71672:1 \u6bd4\u4f8b\u96a8\u6a5f\u5206\u7d44\u9032\u5165\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548c\u7814\u7a76\u8005\u6c7a\u5b9a\u7684BAT\u5c0d\u7167\u7d44\u3002 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\u6b64\u9805\u7814\u7a76\u7684\u5831\u544a\u4eba\u3001\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u6c5f\u5029\u6559\u6388\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6578\u64da\uff0c\u518d\u6b21\u9a57\u8b49\u4e86\u8010\u7acb\u514b\u00ae\u5728TKI\u8010\u85e5\/\u4e0d\u8010\u53d7CML-CP\u60a3\u8005\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u4eba\u7fa4\u4e2d\u7684\u5353\u8d8a\u7642\u6548\uff0c\u8868\u73fe\u51fa\u7684\u9577\u671f\u5b89\u5168\u6027\u7279\u5fb5\u2014\u2014\u7279\u5225\u662f\u8840\u7ba1\u9589\u585e\u4e8b\u4ef6\u767c\u751f\u7387\u70ba7%\uff0c\u70ba\u81e8\u5e8a\u91ab\u751f\u8207\u60a3\u8005\u63d0\u4f9b\u4e86\u81f3\u95dc\u91cd\u8981\u7684\u9577\u671f\u7528\u85e5\u4fe1\u5fc3\u3002\u9019\u4e9b\u6578\u64da\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u8a72\u85e5\u5728\u81e8\u5e8a\u5be6\u8e10\u4e2d\u7684\u91cd\u8981\u5730\u4f4d\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u00a0\u300c\u9019\u9805\u95dc\u9375\u7814\u7a76\u7d93\u904e4\u5e74\u96a8\u8a2a\uff0c\u5176\u6578\u64da\u7684\u6301\u7e8c\u6210\u719f\u8b93\u6211\u5011\u500d\u611f\u9f13\u821e\u3002\u5b83\u4e0d\u50c5\u8b49\u5be6\u4e86\u85e5\u7269\u7684\u6301\u4e45\u7642\u6548\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5c55\u73fe\u4e86\u51fa\u8272\u7684\u9577\u671f\u5b89\u5168\u6027\uff0c\u9019\u76f4\u63a5\u95dc\u4e4e\u60a3\u8005\u7684\u751f\u6d3b\u8cea\u91cf\u8207\u9577\u671f\u7372\u76ca\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u8a3b\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u53ef\u7528\u7642\u6cd5\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a3788\u5206\u6703\u5834\uff1a632. \u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u58c1\u5831\u5c55\u793aII\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0b\u534818:00 \u2013 20:00\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67088\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0a\u53487:00 \u2013 9:00\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\uff0c\u6c5f\u5029\u6559\u6388\u5831\u544a\u4eba\uff1a\u5317\u4eac\u5927\u5b78\u8840\u6db2\u75c5\u7814\u7a76\u6240\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\uff0c\u6c5f\u5029\u6559\u6388\u00a0\u6838\u5fc3\u8981\u9ede\uff1a\u7814\u7a76\u80cc\u666f\uff1aCML\u00a0\u662f\u4e00\u7a2e\u7372\u5f97\u6027\u9020\u8840\u5e72\u7d30\u80de\u60e1\u6027\u514b\u9686\u6027\u75be\u75c5\uff0cTKI\u7684\u51fa\u73fe\u4f7fCML\u60a3\u8005\u7684\u6cbb\u7642\u5fb9\u5e95\u6539\u89c0\u4f46\u4ecd\u6709\u76f8\u7576\u6bd4\u4f8b\u7684\u60a3\u8005\u5728\u6cbb\u7642\u4e2d\u51fa\u73fe\u8010\u85e5\u6216\u56e0\u5b89\u5168\u6027\u4e0d\u8010\u53d7\u505c\u85e5\uff0c\u9032\u800c\u9762\u81e8\u66f4\u70ba\u56b4\u91cd\u7684\u5f8c\u679c\u3002\u56e0\u6b64\uff0c\u8a31\u591a\u5c0d\u4e00\u4ee3\u4e8c\u4ee3TKI\u00a0\u5747\u8010\u85e5\/\u4e0d\u8010\u53d7\u7684CML\u00a0\u60a3\u8005\uff0c\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u4e14\u8a72\u985e\u60a3\u8005\u6709\u8457\u660e\u78ba\u75c5\u60c5\u9032\u5c55\u7684\u98a8\u96aa\u3002\u5967\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u7a2e\u5f37\u6548\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff0c\u5c0d\u651c\u5e36\u91ce\u751f\u578bBCR-ABL\u7684CML\u548c\u651c\u5e36BCR-ABL-T315I\u7a81\u8b8a\uff08\u53ef\u5c0e\u81f4\u5c0d\u65bc\u4f0a\u99ac\u66ff\u5c3c\u548c\u7b2c\u4e8c\u4ee3TKI\u8010\u85e5\uff09\u7684CML\u60a3\u8005\u5747\u6709\u8f03\u5f37\u7642\u6548\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a \u8a72\u7814\u7a76\uff08NCT04126681\uff09\u662f\u4e00\u9805\u958b\u653e\u6027\u3001\u96a8\u6a5f\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u95dc\u9375\u8a3b\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u5c0d\u4e00\u4ee3\u548c\u4e8c\u4ee3TKI\u5747\u8010\u85e5\u548c\/\u6216\u4e0d\u8010\u53d7\u7684CML-CP\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u672c\u5831\u544a\u70ba\u4e00\u98052023ASH\u5e74\u6703\u53e3\u982d\u5831\u544a\u7684\u7814\u7a76\u66f4\u65b0\u6578\u64da\u3002\u622a\u81f32025\u5e741\u670813\u65e5\uff0c\u5171\u6709144\u4f8bCML-CP\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d105\u4f8b\u70ba\u4e0d\u4f34T315I\u7a81\u8b8a\u60a3\u8005\u3002 \u5728\u672c\u7814\u7a76\u4e2d\uff0c\u60a3\u8005\u88ab\u6309\u71672:1 \u6bd4\u4f8b\u96a8\u6a5f\u5206\u7d44\u9032\u5165\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548c\u7814\u7a76\u8005\u6c7a\u5b9a\u7684BAT\u5c0d\u7167\u7d44\u3002 \u4e3b\u8981\u7d42\u9ede\u70ba\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u3002\u4e8b\u4ef6\u7684\u5b9a\u7fa9\u70ba\uff1a\u75be\u75c5\u9032\u5c55\u3001\u9054\u5230\u53c8\u6d88\u5931\u7684\u5b8c\u5168\u8840\u6db2\u5b78\u7de9\u89e3\uff08CHR\uff09\u3001\u4e3b\u8981\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\u3001\u5b8c\u5168\u7d30\u80de\u907a\u50b3\u5b78\u53cd\u61c9\uff08CCyR\uff09\uff1b\u6cbb\u7642\u5931\u6557\uff1b3\u500b\u6cbb\u7642\u9031\u671f\u5167\u672a\u9054CHR\uff1b\u4efb\u4f55\u539f\u56e0\u5c0e\u81f4\u7684\u6b7b\u4ea1\uff1b\u4e0d\u53ef\u63a5\u53d7\u7684\u85e5\u7269\u6bd2\u6027\u3002 \u7642\u6548\u6578\u64da\uff1a \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u986f\u8457\u9577\u65bcBAT\u6cbb\u7642\u7d44\uff1a\u5728\u6240\u6709CMP-CP\u60a3\u8005\u4e2d\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u7d44\u548cBAT\u6cbb\u7642\u7d44\u7684\u4e2d\u4f4dEFS\u5206\u5225\u70ba21.2\u500b\u6708\u548c2.9\u500b\u6708\uff08P < 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