{"id":390472,"date":"2025-12-08T11:54:00","date_gmt":"2025-12-08T03:54:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=390472"},"modified":"2025-12-08T11:54:00","modified_gmt":"2025-12-08T03:54:00","slug":"%e3%80%90%e7%9b%b4%e6%93%8a2025-ash%e3%80%91%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91%e5%88%a9%e7%94%9f%e5%a6%a5%e6%b2%bb%e7%99%82%e7%b6%ad%e5%a5%88%e5%85%8b%e6%8b%89","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=390472","title":{"rendered":"\u3010\u76f4\u64ca2025 ASH\u3011\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291\u5229\u751f\u59a5\u00ae\u6cbb\u7642\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u9ad3\u7cfb\u816b\u7624\u60a3\u8005\u7684Ib\/II\u671f\u7814\u7a76\u6578\u64da\u7a4d\u6975\uff0c\u5168\u7403\u7af6\u722d\u529b\u6301\u7e8c\u986f\u73fe"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n
  • \u81e8\u5e8a\u8b49\u64da\u986f\u793a\uff0c\u5229\u751f\u59a5<\/i>\u00ae<\/sup><\/i>\u53ef\u6709\u6548\u514b\u670d\u9ad3\u7cfb\u816b\u7624\u60a3\u8005\u5c0d\u7dad\u5948\u514b\u62c9\u7684\u8010\u85e5\uff0c\u8a72\u985e\u60a3\u8005\u7684\u7e3d\u9ad4\u7de9\u89e3\u7387<\/i>(ORR)<\/i>\u9054<\/i>31.8%<\/i><\/li>\n
  • \u65b0\u8a3a\u65b7\u7684\u4e2d\u9ad8\u5371\uff08<\/i>HR<\/i>\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08<\/i>MDS<\/i>\uff09<\/i>\/<\/i>\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08<\/i>CMML<\/i>\uff09\u60a3\u8005\u7684<\/i>ORR<\/i>\u9054<\/i>80%<\/i><\/li>\n
  • \u5229\u751f\u59a5<\/i>\u00ae<\/sup><\/i>\u806f\u5408\u7642\u6cd5\u986f\u793a\u4e86\u512a\u7570\u7684\u5b89\u5168\u6027\uff0c\u5168\u90e8<\/i>103<\/i>\u540d\u53d7\u8a66\u60a3\u8005\u4e2d\u672a\u767c\u751f\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027<\/i><\/li>\n<\/ul>\n

    \u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2025\u5e7412\u67088\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u570b\u4f5b\u7f85\u91cc\u9054\u5dde\u5967\u862d\u591a\u5e02\u8209\u8fa6\u7684\u7b2c67\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u4f48\u4e86\u6838\u5fc3\u7522\u54c1\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5\u00ae<\/sup>\uff1b\u7814\u767c\u4ee3\u865f\uff1aAPG-2575\uff09 \u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u9ad3\u7cfb\u816b\u7624\u60a3\u8005\u7684Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u6578\u64da\u3002<\/p>\n

    \n<\/p><\/div>\n

    ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u5728\u6b64\u6b21\u6703\u8b70\u4e0a\uff0c\u4e9e\u76db\u91ab\u85e5\u7684\u591a\u500b\u5275\u65b0\u6210\u679c\u518d\u5ea6\u7372\u5f97\u570b\u969b\u5b78\u8853\u754c\u7684\u95dc\u6ce8\uff0c\u00a0\u4e09\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u00ae<\/sup>\u3001\u5229\u751f\u59a5\u00ae<\/sup>\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5229\u751f\u59a5\u00ae<\/sup>\u4e00\u9805\u81e8\u5e8a\u7814\u7a76\u7372\u53e3\u982d\u5831\u544a\u3002<\/p>\n

    \u6b64\u6b21\u6578\u64da\u9032\u4e00\u6b65\u9a57\u8b49\u4e86\u5229\u751f\u59a5\u00ae<\/sup>\u5728\u60e1\u6027\u9ad3\u7cfb\u816b\u7624\u9818\u57df\u6240\u5177\u5099\u7684\u7a69\u5065\u7642\u6548\u8207\u826f\u597d\u5b89\u5168\u6027\u3002\u8a72\u85e5\u7269\u5728\u5c0d\u7dad\u5948\u514b\u62c9\u8010\u85e5\u7684\u60a3\u8005\u4e2d\u4f9d\u7136\u8868\u73fe\u51fa\u6cbb\u7642\u61c9\u7b54\uff0c\u63d0\u793a\u5229\u751f\u59a5\u00ae<\/sup>\u5177\u5099\u5340\u5225\u65bc\u540c\u985e\u7522\u54c1\u7684\u660e\u986f\u7684\u81e8\u5e8a\u6cbb\u7642\u512a\u52e2\u3002<\/p>\n

    \u5229\u751f\u59a5\u00ae<\/sup>\u662f\u4e9e\u76db\u91ab\u85e5\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u53e3\u670dBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\uff0c\u901a\u904e\u9078\u64c7\u6027\u6291\u5236Bcl-2\u86cb\u767d\uff0c\u6062\u5fa9\u764c\u7d30\u80de\u7684\u6b63\u5e38\u51cb\u4ea1\u904e\u7a0b\uff0c\u5f9e\u800c\u9054\u5230\u6cbb\u7642\u816b\u7624\u7684\u76ee\u7684\u3002\u76ee\u524d\uff0c\u8a72\u85e5\u7269\u5df2\u5728\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8a72\u85e5\u7269\u56db\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u6d89\u53caCLL\/SLL\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u548c\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u5e7e\u5927\u9069\u61c9\u75c7\u3002<\/p>\n

    \u6b64\u9805\u7814\u7a76\u7684\u5831\u544a\u4eba\u3001<\/b>MD<\/b>\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3<\/b>Tapan Kadia<\/span><\/b>\u535a\u58eb\u8868\u793a\uff1a<\/b> \u300c \u5728\u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\u4e2d\uff0c\u5229\u751f\u59a5\u00ae<\/sup>\u8207\u963f\u624e\u80de\u7518\u7684\u5354\u540c\u4f5c\u7528\u6301\u7e8c\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u767d\u8840\u75c5\u7642\u6548\u3002\u5c24\u70ba\u91cd\u8981\u7684\u662f\uff0c\u6211\u5011\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u5931\u6557\u7684\u60a3\u8005\u968a\u5217\u4e2d\u89c0\u5bdf\u5230\u4e86\u986f\u8457\u7684\u6cbb\u7642\u53cd\u61c9\uff0c\u9019\u70ba\u5229\u751f\u59a5\u00ae<\/sup>\u53ef\u4ee5\u514b\u670d\u5176\u5b83Bcl-2\u6291\u5236\u5291\u63d0\u4f9b\u4e86\u81e8\u5e8a\u4f9d\u64da\u3002\u672a\u4f86\u6578\u64da\u7684\u4e0d\u65b7\u7a4d\u7d2f\uff0c\u5c07\u6709\u52a9\u65bc\u6df1\u5316\u5c0d\u5176\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u8207\u7bc4\u570d\u7684\u8a8d\u77e5\u3002\u300d<\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a<\/b>\u300c\u6211\u5011\u5f88\u9ad8\u8208\u5728ASH\u5e74\u6703\u4e0a\u5c55\u793a\u5229\u751f\u59a5\u00ae<\/sup>\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u816b\u7624\u9818\u57df\u7684\u6301\u7e8c\u9032\u5c55\uff0c\u9019\u4e9b\u6578\u64da\u9032\u4e00\u6b65\u8868\u660e\u4e86\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u5728\u521d\u6cbb\u548c\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7684\u5de8\u5927\u6cbb\u7642\u6f5b\u529b\u3002\u671f\u5f85\u5229\u751f\u59a5\u00ae<\/sup>\u5728\u672a\u4f86\uff0c\u80fd\u70ba\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u6cbb\u7642\u9818\u57df\u5e36\u4f86\u65b0\u7684\u7a81\u7834\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d<\/p>\n

    \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n

    Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies<\/b><\/p>\n

    \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08<\/b>APG2575AU101<\/b>\uff09\u7d50\u679c<\/b><\/p>\n

    \u5c55\u793a\u5f62\u5f0f<\/b>\uff1a\u58c1\u5831\u5c55\u793a<\/p>\n

    \u6458\u8981\u7de8\u865f<\/b>\uff1a1641<\/p>\n

    \u5206\u6703\u5834<\/b>\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI<\/p>\n

    \u5831\u544a\u6642\u9593<\/b>\uff1a<\/p>\n

    2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff09<\/p>\n

    2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09<\/p>\n

    \u7b2c\u4e00\u4f5c\u8005<\/b>\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb<\/p>\n

    \u5831\u544a\u4eba<\/b>\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb<\/p>\n

    \u6838\u5fc3\u8981\u9ede<\/b>\uff1a<\/p>\n

    \u7814\u7a76\u80cc\u666f<\/u>\uff1a<\/p>\n

      \n
    • AML\u548cMDS\u81e8\u5e8a\u9810\u5f8c\u5dee\u3002\u7dad\u5948\u514b\u62c9\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\u963f\u624e\u80de\u7518(AZA)\u65b9\u6848\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u67d0\u4e9bAML\u60a3\u8005\uff0c\u4f46\u5c0d\u6cbb\u7642\u7121\u53cd\u61c9\u6216\u4e0d\u80fd\u8010\u53d7\u6cbb\u7642\u526f\u4f5c\u7528\u662f\u81e8\u5e8a\u5e38\u898b\u7684\u60a3\u8005\u4e0d\u80fd\u9577\u671f\u7372\u76ca\u7684\u539f\u56e0\u3002\u5373\u4f7f\u5728\u521d\u671f\u7684\u6cbb\u7642\u4e2d\u7372\u5f97\u5b8c\u5168\u7de9\u89e3(CR)\u7684\u60a3\u8005\u6700\u7d42\u4e5f\u96e3\u514d\u6703\u5fa9\u767c\u3002<\/li>\n
    • \u5229\u6c99\u6258\u514b\u62c9\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5728\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u7814\u7a76\u4e2d\u8207AZA\u806f\u5408\u4f7f\u7528\u6642\u986f\u793a\u51fa\u4e86\u589e\u5f37\u7642\u6548\u7684\u5354\u540c\u4f5c\u7528\u3002<\/li>\n<\/ul>\n

      \u7814\u7a76\u4ecb\u7d39<\/u>\uff1a<\/p>\n

        \n
      • \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002<\/li>\n
      • \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002<\/li>\n<\/ul>\n

        \u7642\u6548\u6578\u64da<\/u>\uff1a<\/p>\n

          \n
        • 44\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005ORR\u70ba43.2%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba31.8%\uff0814\/44\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768422\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba31.8% (7\/22)\uff0cCR\u7387\u70ba22.7%\uff085\/22\uff09\uff1b<\/li>\n
        • 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b<\/li>\n
        • R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b<\/li>\n
        • \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002<\/li>\n<\/ul>\n

          \u5b89\u5168\u6027\u6578\u64da<\/u>\uff1a\u7b2c1\u90e8\u5206\u5291\u91cf\u905e\u589e\u968e\u6bb5\u53ca\u7b2c2\u90e8\u5206\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u5747\u672a\u767c\u751f\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u904e\u7a0b\u4e2d\u767c\u751f\u7684\u4e0d\u826f\u53cd\u61c9\uff08TEAEs\uff09\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0841.7%\uff09\u3001\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0835.0%\uff09\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\uff0826.2%\uff09\u3001\u8ca7\u8840\uff0817.5%\uff09\u3002<\/p>\n

          \u7d50\u8ad6<\/u>\uff1a\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u986f\u793a\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u7684\u6cbb\u7642\u65b9\u6848\u6709\u53ef\u80fd\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\uff0c\u70baAML\/HR MDS\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u5e0c\u671b\u3002<\/p>\n

          \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/b><\/p>\n

          \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002<\/p>\n

          \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002<\/p>\n

          \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae<\/sup>\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae<\/sup>\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002<\/p>\n

          \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\u5229\u751f\u59a5\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u570b\u7522\u539f\u5275Bcl-2\u6291\u5236\u5291\uff0c\u5df2\u7372\u6279\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u5229\u751f\u59a5\u00ae<\/sup>\u56db\u9805\u5168\u7403\u8a3b\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA\u7814\u7a76\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684GLORA-2\u7814\u7a76\uff1b\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684GLORA-3\u7814\u7a76\uff1b\u4ee5\u53ca\u7372\u7f8e\u570bFDA\u3001\u6b50\u6d32EMA\u8207\u4e2d\u570bCDE\u540c\u6b65\u6279\u51c6\u958b\u5c55\u7684\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684GLORA-4\u7814\u7a76\u3002<\/p>\n

          \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u7bc4\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u4f48\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002<\/p>\n

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          \u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n

          \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002<\/p>\n

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2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09 \u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a AML\u548cMDS\u81e8\u5e8a\u9810\u5f8c\u5dee\u3002\u7dad\u5948\u514b\u62c9\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\u963f\u624e\u80de\u7518(AZA)\u65b9\u6848\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u67d0\u4e9bAML\u60a3\u8005\uff0c\u4f46\u5c0d\u6cbb\u7642\u7121\u53cd\u61c9\u6216\u4e0d\u80fd\u8010\u53d7\u6cbb\u7642\u526f\u4f5c\u7528\u662f\u81e8\u5e8a\u5e38\u898b\u7684\u60a3\u8005\u4e0d\u80fd\u9577\u671f\u7372\u76ca\u7684\u539f\u56e0\u3002\u5373\u4f7f\u5728\u521d\u671f\u7684\u6cbb\u7642\u4e2d\u7372\u5f97\u5b8c\u5168\u7de9\u89e3(CR)\u7684\u60a3\u8005\u6700\u7d42\u4e5f\u96e3\u514d\u6703\u5fa9\u767c\u3002 \u5229\u6c99\u6258\u514b\u62c9\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5728\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u7814\u7a76\u4e2d\u8207AZA\u806f\u5408\u4f7f\u7528\u6642\u986f\u793a\u51fa\u4e86\u589e\u5f37\u7642\u6548\u7684\u5354\u540c\u4f5c\u7528\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a 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\u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a 44\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005ORR\u70ba43.2%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba31.8%\uff0814\/44\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768422\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba31.8% (7\/22)\uff0cCR\u7387\u70ba22.7%\uff085\/22\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR 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ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u8a3b\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 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\u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u6458\u8981\u7de8\u865f\uff1a1641 \u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI \u5831\u544a\u6642\u9593\uff1a 2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff09 2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09 \u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a AML\u548cMDS\u81e8\u5e8a\u9810\u5f8c\u5dee\u3002\u7dad\u5948\u514b\u62c9\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\u963f\u624e\u80de\u7518(AZA)\u65b9\u6848\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u67d0\u4e9bAML\u60a3\u8005\uff0c\u4f46\u5c0d\u6cbb\u7642\u7121\u53cd\u61c9\u6216\u4e0d\u80fd\u8010\u53d7\u6cbb\u7642\u526f\u4f5c\u7528\u662f\u81e8\u5e8a\u5e38\u898b\u7684\u60a3\u8005\u4e0d\u80fd\u9577\u671f\u7372\u76ca\u7684\u539f\u56e0\u3002\u5373\u4f7f\u5728\u521d\u671f\u7684\u6cbb\u7642\u4e2d\u7372\u5f97\u5b8c\u5168\u7de9\u89e3(CR)\u7684\u60a3\u8005\u6700\u7d42\u4e5f\u96e3\u514d\u6703\u5fa9\u767c\u3002 \u5229\u6c99\u6258\u514b\u62c9\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5728\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u7814\u7a76\u4e2d\u8207AZA\u806f\u5408\u4f7f\u7528\u6642\u986f\u793a\u51fa\u4e86\u589e\u5f37\u7642\u6548\u7684\u5354\u540c\u4f5c\u7528\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a 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\u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a 44\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005ORR\u70ba43.2%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba31.8%\uff0814\/44\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768422\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba31.8% (7\/22)\uff0cCR\u7387\u70ba22.7%\uff085\/22\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR 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\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u5728ASH\u5e74\u6703\u4e0a\u5c55\u793a\u5229\u751f\u59a5\u00ae\u5728AML\u3001MDS\u7b49\u9ad3\u7cfb\u816b\u7624\u9818\u57df\u7684\u6301\u7e8c\u9032\u5c55\uff0c\u9019\u4e9b\u6578\u64da\u9032\u4e00\u6b65\u8868\u660e\u4e86\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u5728\u521d\u6cbb\u548c\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u60a3\u8005\u4e2d\u7684\u5de8\u5927\u6cbb\u7642\u6f5b\u529b\u3002\u671f\u5f85\u5229\u751f\u59a5\u00ae\u5728\u672a\u4f86\uff0c\u80fd\u70ba\u9ad3\u7cfb\u60e1\u6027\u816b\u7624\u6cbb\u7642\u9818\u57df\u5e36\u4f86\u65b0\u7684\u7a81\u7834\u3002\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88\u300e\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300f\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u6458\u8981\u7de8\u865f\uff1a1641 \u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI \u5831\u544a\u6642\u9593\uff1a 2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff09 2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09 \u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a AML\u548cMDS\u81e8\u5e8a\u9810\u5f8c\u5dee\u3002\u7dad\u5948\u514b\u62c9\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\u963f\u624e\u80de\u7518(AZA)\u65b9\u6848\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u67d0\u4e9bAML\u60a3\u8005\uff0c\u4f46\u5c0d\u6cbb\u7642\u7121\u53cd\u61c9\u6216\u4e0d\u80fd\u8010\u53d7\u6cbb\u7642\u526f\u4f5c\u7528\u662f\u81e8\u5e8a\u5e38\u898b\u7684\u60a3\u8005\u4e0d\u80fd\u9577\u671f\u7372\u76ca\u7684\u539f\u56e0\u3002\u5373\u4f7f\u5728\u521d\u671f\u7684\u6cbb\u7642\u4e2d\u7372\u5f97\u5b8c\u5168\u7de9\u89e3(CR)\u7684\u60a3\u8005\u6700\u7d42\u4e5f\u96e3\u514d\u6703\u5fa9\u767c\u3002 \u5229\u6c99\u6258\u514b\u62c9\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5728\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u7814\u7a76\u4e2d\u8207AZA\u806f\u5408\u4f7f\u7528\u6642\u986f\u793a\u51fa\u4e86\u589e\u5f37\u7642\u6548\u7684\u5354\u540c\u4f5c\u7528\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002 \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a 44\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005ORR\u70ba43.2%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba31.8%\uff0814\/44\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768422\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba31.8% (7\/22)\uff0cCR\u7387\u70ba22.7%\uff085\/22\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u7b2c1\u90e8\u5206\u5291\u91cf\u905e\u589e\u968e\u6bb5\u53ca\u7b2c2\u90e8\u5206\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u5747\u672a\u767c\u751f\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u904e\u7a0b\u4e2d\u767c\u751f\u7684\u4e0d\u826f\u53cd\u61c9\uff08TEAEs\uff09\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0841.7%\uff09\u3001\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0835.0%\uff09\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\uff0826.2%\uff09\u3001\u8ca7\u8840\uff0817.5%\uff09\u3002 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\u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 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\u6b64\u9805\u7814\u7a76\u7684\u5831\u544a\u4eba\u3001MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3Tapan Kadia\u535a\u58eb\u8868\u793a\uff1a \u300c \u5728\u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\u4e2d\uff0c\u5229\u751f\u59a5\u00ae\u8207\u963f\u624e\u80de\u7518\u7684\u5354\u540c\u4f5c\u7528\u6301\u7e8c\u5c55\u73fe\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u767d\u8840\u75c5\u7642\u6548\u3002\u5c24\u70ba\u91cd\u8981\u7684\u662f\uff0c\u6211\u5011\u5728\u7dad\u5948\u514b\u62c9\u7d93\u6cbb\u5931\u6557\u7684\u60a3\u8005\u968a\u5217\u4e2d\u89c0\u5bdf\u5230\u4e86\u986f\u8457\u7684\u6cbb\u7642\u53cd\u61c9\uff0c\u9019\u70ba\u5229\u751f\u59a5\u00ae\u53ef\u4ee5\u514b\u670d\u5176\u5b83Bcl-2\u6291\u5236\u5291\u63d0\u4f9b\u4e86\u81e8\u5e8a\u4f9d\u64da\u3002\u672a\u4f86\u6578\u64da\u7684\u4e0d\u65b7\u7a4d\u7d2f\uff0c\u5c07\u6709\u52a9\u65bc\u6df1\u5316\u5c0d\u5176\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u8207\u7bc4\u570d\u7684\u8a8d\u77e5\u3002\u300d 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\u6b64\u9805\u7814\u7a76\u57282025 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u6458\u8981\u7de8\u865f\uff1a1641 \u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI \u5831\u544a\u6642\u9593\uff1a 2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff09 2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09 \u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a AML\u548cMDS\u81e8\u5e8a\u9810\u5f8c\u5dee\u3002\u7dad\u5948\u514b\u62c9\u806f\u5408\u53bb\u7532\u57fa\u5316\u85e5\u7269\u963f\u624e\u80de\u7518(AZA)\u65b9\u6848\u5df2\u88ab\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u67d0\u4e9bAML\u60a3\u8005\uff0c\u4f46\u5c0d\u6cbb\u7642\u7121\u53cd\u61c9\u6216\u4e0d\u80fd\u8010\u53d7\u6cbb\u7642\u526f\u4f5c\u7528\u662f\u81e8\u5e8a\u5e38\u898b\u7684\u60a3\u8005\u4e0d\u80fd\u9577\u671f\u7372\u76ca\u7684\u539f\u56e0\u3002\u5373\u4f7f\u5728\u521d\u671f\u7684\u6cbb\u7642\u4e2d\u7372\u5f97\u5b8c\u5168\u7de9\u89e3(CR)\u7684\u60a3\u8005\u6700\u7d42\u4e5f\u96e3\u514d\u6703\u5fa9\u767c\u3002 \u5229\u6c99\u6258\u514b\u62c9\u662f\u4e00\u7a2e\u65b0\u578b\u7684\u53e3\u670d\u5c0f\u5206\u5b50Bcl-2\u6291\u5236\u5291\uff0c\u5728\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u7814\u7a76\u4e2d\u8207AZA\u806f\u5408\u4f7f\u7528\u6642\u986f\u793a\u51fa\u4e86\u589e\u5f37\u7642\u6548\u7684\u5354\u540c\u4f5c\u7528\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805Ib\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002 \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a 44\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005ORR\u70ba43.2%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba31.8%\uff0814\/44\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768422\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba31.8% (7\/22)\uff0cCR\u7387\u70ba22.7%\uff085\/22\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u7b2c1\u90e8\u5206\u5291\u91cf\u905e\u589e\u968e\u6bb5\u53ca\u7b2c2\u90e8\u5206\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u5747\u672a\u767c\u751f\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u904e\u7a0b\u4e2d\u767c\u751f\u7684\u4e0d\u826f\u53cd\u61c9\uff08TEAEs\uff09\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0841.7%\uff09\u3001\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0835.0%\uff09\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\uff0826.2%\uff09\u3001\u8ca7\u8840\uff0817.5%\uff09\u3002 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2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09 \u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a 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