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content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e9e\u76db\u91ab\u85e5\u8010\u7acb\u514b\u00ae\u80c3\u8178\u9053\u9593\u8cea\u7624\u9818\u57df\u7814\u7a76\u9032\u5c55\u5728\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300aSignal Transduction and Targeted Therapy\u300b\u767c\u8868 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u9019\u662f\u8fc4\u4eca\u70ba\u6b62\u91dd\u5c0d\u4e00\u500bGIST\u7f55\u898b\u5206\u578b\u7684\u6700\u5927\u898f\u6a21\u524d\u77bb\u6027\u81e8\u5e8a\u7814\u7a76 \u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2025\u5e7411\u670825\u65e5 \/\u7f8e\u901a\u793e\/ -- 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Therapy\uff0c\u5f71\u97ff\u56e0\u5b5052.7\uff09\u6210\u529f\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u8868\u660e\u5967\u96f7\u5df4\u66ff\u5c3c\u5728\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578bGIST\u4e2d\u5177\u6709\u826f\u597d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff0c\u4e26\u9996\u6b21\u63ed\u793a\u5967\u96f7\u5df4\u66ff\u5c3c\u901a\u904e\u8abf\u63a7\u8102\u8cea\u4ee3\u8b1d\u767c\u63ee\u6297\u816b\u7624\u4f5c\u7528\u7684\u5168\u65b0\u6a5f\u5236\u3002     \u300a\u4fe1\u865f\u8f49\u5c0e\u8207\u9776\u5411\u6cbb\u7642\u300b\uff08Signal Transduction and Targeted Therapy\uff09\u662f\u570b\u969b\u77e5\u540d\u6b0a\u5a01\u671f\u520a\uff0c\u96b8\u5c6c\u65bc\u300a\u81ea\u7136\u300b\uff08Nature\uff09\u51fa\u7248\u96c6\u5718\u3002\u8a72\u671f\u520a\u4e3b\u8981\u767c\u8868\u95dc\u65bc\u764c\u75c7\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u53ca\u5176\u4ed6\u75be\u75c5\u4e2d\u300c\u4fe1\u865f\u8f49\u5c0e\u9776\u5411\u6cbb\u7642\u300d\u9818\u57df\u524d\u6cbf\u57fa\u790e\u5be6\u9a57\u8207\u81e8\u5e8a\u7814\u7a76\u9032\u5c55\u7684\u539f\u5275\u6027\u6210\u679c\uff0c\u5176\u5f71\u97ff\u56e0\u5b50\u9ad8\u905452.7\u3002 \u6b64\u6b21\u767c\u8868\u5728\u8a72\u671f\u520a\u4e0a\u7684\u7814\u7a76\u984c\u70ba\u300cOlverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational 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