{"id":380797,"date":"2025-11-10T21:30:00","date_gmt":"2025-11-10T13:30:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=380797"},"modified":"2025-11-10T21:30:00","modified_gmt":"2025-11-10T13:30:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82025%e5%b9%b4aasld%e5%a4%a7%e6%9c%83%e4%b8%8a%e7%99%bc%e4%bd%88ensure-ii%e6%9c%9f%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e7%aa%81%e7%a0%b4%e6%80%a7%e6%95%b8","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=380797","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u57282025\u5e74AASLD\u5927\u6703\u4e0a\u767c\u4f48ENSURE II\u671f\u7814\u7a76\u6700\u65b0\u7a81\u7834\u6027\u6578\u64da\uff0c\u9032\u4e00\u6b65\u5f37\u8abfBRII-179\u4f5c\u70ba\u6162\u4e59\u809d\u6cbb\u7652\u6027\u7642\u6cd5\u7684\u6f5b\u529b"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li><i>\u968a\u5217<\/i><i>4<\/i><i>\u96a8\u8a2a\u6578\u64da\u986f\u793a\uff0c\u63a5\u53d7<\/i><i>elebsiran<\/i><i>\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20<\/i><i>\u03b1<\/i><i>\uff08<\/i><i>PEG-IFN\u03b1<\/i><i>\uff09\u6cbb\u7642\u7684<\/i><i>BRII-179<\/i><i>\u6297<\/i><i>-HBs<\/i><i>\u61c9\u7b54\u8005\uff0c\u5728\u6cbb\u7642\u7d50\u675f\uff08<\/i><i>EOT<\/i><i>\uff09\u5f8c<\/i><i>24<\/i><i>\u5468\u4ecd\u7dad\u6301<\/i><i>HBsAg<\/i><i>\u6e05\u9664\u72c0\u614b\u3002<\/i><\/li>\n<li><i>\u6578\u64da\u8868\u660e\uff0c<\/i><i>BRII-179<\/i><i>\u6297<\/i><i>-HBs<\/i><i>\u61c9\u7b54\u8005<\/i><i>HBsAg<\/i><i>\u4e0b\u964d\u901f\u5ea6\u66f4\u5feb\u3001\u5e45\u5ea6\u66f4\u5927\uff0c\u9019\u70ba\u7e2e\u77ed<\/i><i>PEG-IFN<\/i><i>\u03b1\u6cbb\u7642\u9031\u671f\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002<\/i><\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e02<\/span><span class=\"legendSpanClass\">2025\u5e7411\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; <a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">\u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u75be\u75c5\u958b\u767c\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u5065\u5eb7\u72c0\u6cc1\u548c\u6cbb\u7642\u9078\u64c7\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u4e86\u5176\u6b63\u5728\u9032\u884c\u7684ENSURE II\u671f\u7814\u7a76\u968a\u52174\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c24\u5468\u7684\u96a8\u8a2a\u7d50\u679c\u3002\u9019\u4e9b\u6700\u65b0\u6578\u64da\u65bc2025\u5e7411\u67087\u65e5\u81f311\u65e5\u5728\u83ef\u76db\u9813\u7279\u5340\u8209\u884c\u7684\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\uff08AASLD\uff09\u809d\u75c5\u6703\u8b70<sup>\u00ae<\/sup>\u4e0a\u516c\u4f48\uff0c\u4e26\u5df2\u540c\u6b65\u767c\u8868\u65bc\u300a\u81ea\u7136-\u91ab\u5b78\u300b\u96dc\u8a8c\uff08<a href=\"https:\/\/www.nature.com\/articles\/s41591-025-04049-z\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">\u93c8\u63a5<\/a>\uff09\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/p><\/div>\n<p>ENSURE\uff08NCT05970289\uff09\u662f\u4e00\u9805\u5728\u4e9e\u592a\u5730\u5340\u958b\u5c55\u7684\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6a19\u7c64II\u671f\u7814\u7a76\u3002\u968a\u52174\u8a55\u4f30\u4e86\u4e00\u7a2e\u5275\u65b0\u7684\u4e59\u578b\u809d\u708e\uff08HBV\uff09\u5e8f\u8cab\u806f\u5408\u6cbb\u7642\u7b56\u7565\uff0c\u5229\u7528\u9a30\u76db\u535a\u85e5\u7684\u6cbb\u7642\u6027\u75ab\u82d7BRII-179\u9032\u884c\u60a3\u8005\u514d\u75ab\u6fc0\u6d3b\u548c\u5bcc\u96c6\uff0c\u4ee5\u63d0\u9ad8\u5176\u5c0d\u6f5b\u5728\u529f\u80fd\u6027\u6cbb\u7652\u7642\u6cd5\u7684\u61c9\u7b54\u3002\u8a72\u968a\u5217\u7d0d\u5165\u4e86\u6b64\u524d\u5728BRII-179-835-001 II\u671f\u7814\u7a76\uff08NCT04749368\uff09\u4e2d\u63a5\u53d7\u904e9\u5291elebsiran\u806f\u5408BRII-179\u7d66\u85e5\u7684\u53c3\u8207\u8005\uff0c\u4f7f\u5176\u63a5\u53d7\u70ba\u671f48\u5468\u7684elebsiran\u8207PEG-IFN\u03b1\u806f\u5408\u6cbb\u7642\u3002\u6839\u64da\u5148\u524d\u7814\u7a76\u4e2d\u6297-HBs\u6ef4\u5ea6\u5cf0\u503c\u6c34\u5e73\uff08\u226510 IU\/L\u6216&lt;10 IU\/L\uff09\uff0c\u53c3\u8207\u8005\u88ab\u5b9a\u7fa9\u70baBRII-179\u6297-HBs\u61c9\u7b54\u8005\u6216\u7121\u61c9\u7b54\u8005\u3002<\/p>\n<p>\u968a\u52174\u7684EOT\u6578\u64da\u6b64\u524d\u5df2\u5728<a href=\"https:\/\/www.briibio.com\/en\/media\/press-release\/20250508\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">2025\u5e74\u6b50\u6d32\u809d\u75c5\u7814\u7a76\u5354\u6703\uff08EASL\uff09\u6703\u8b70\u4e0a\u516c\u4f48<\/a>\u3002\u6700\u65b0\u516c\u4f48\u7684\u6578\u64da\u8868\u660e\uff0c\u5728BRII-179\u61c9\u7b54\u8005\u7d44\u4e2dHBsAg\u6e05\u9664\u7684\u7372\u76ca\u6548\u679c\u5728\u96a8\u8a2a\u671f\u9593\u5f97\u4ee5\u6301\u7e8c\u7dad\u6301\u3002\u5728EOT\u6642\uff0cBRII-179\u6297-HBs\u61c9\u7b54\u8005\u4e2d\u89c0\u5bdf\u523058%\uff0811\/19\uff09\u5be6\u73fe\u4e86HBsAg\u6e05\u9664\u3002\u5728\u6297-HBs\u7121\u61c9\u7b54\u8005\u4e2d\uff0c\u50c517%\uff082\/12\uff09\u5be6\u73fe\u4e86HBsAg\u6e05\u9664\u3002\u6cbb\u7642\u7d50\u675f24\u5468\u5f8c\uff0c42%\uff088\/19\uff09\u7684\u6297-HBs\u61c9\u7b54\u8005\u7dad\u6301HBsAg\u6e05\u9664\u72c0\u614b\uff0c\u800c\u6297-HBs\u7121\u61c9\u7b54\u8005\u4e2d\u50c58%\uff081\/12\uff09\u7dad\u6301\u8a72\u72c0\u614b\u3002\u5728\u5148\u524dBRII-179-835-001\u7814\u7a76\u4e2d\uff0c50%\uff084\/8\uff09\u65bcEOT\u5f8c24\u5468\u5f8c\u6301\u7e8cHBsAg\u6e05\u9664\u7684\u6297-HBs\u61c9\u7b54\u8005\uff0c\u5176HBsAg\u57fa\u7dda\u6c34\u5e73\u4ecb\u65bc1,514-3,086 IU\/mL\u4e4b\u9593\uff0c\u9019\u8868\u660eBRII-179\u5373\u4f7f\u5728HBsAg\u57fa\u7dda\u6c34\u5e73\u8f03\u9ad8\u7684\u60a3\u8005\u4e2d\u4e5f\u80fd\u8a98\u5c0e\u6297-HBs\u61c9\u7b54\u3002\u9019\u652f\u6301\u4e86BRII-179\u5728\u6539\u5584\u529f\u80fd\u6027\u6cbb\u7652\u7d50\u679c\u65b9\u9762\u7684\u6f5b\u529b\uff0c\u4e26\u6709\u671b\u62d3\u5bec\u5176\u5728\u4e0d\u540c\u60a3\u8005\u7fa4\u9ad4\u4e2d\u7684\u9069\u7528\u7bc4\u570d\u3002<\/p>\n<p>\u70ba\u9032\u4e00\u6b65\u660e\u78baBRII-179\u5728HBV\u611f\u67d3\u6cbb\u7642\u4e2d\u7684\u4f5c\u7528\u4e26\u512a\u5316\u95dc\u9375\u6027\u7814\u7a76\u7684\u806f\u5408\u7642\u6cd5\uff0c\u9a30\u76db\u535a\u85e5\u6b63\u5728\u958b\u5c55\u5169\u9805\u984d\u5916\u7684IIb\u671f\u7814\u7a76\u3002ENRICH\u7814\u7a76\u65e8\u5728\u8a55\u4f30BRII-179\u5728\u8a98\u5c0eHBV\u7279\u7570\u6027\u514d\u75ab\u53ca\/\u6216\u8b58\u5225\u66f4\u53ef\u80fd\u5be6\u73fe\u529f\u80fd\u6027\u6cbb\u7652\u7684\u514d\u75ab\u61c9\u7b54\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002ENHANCE\u7814\u7a76\u5305\u542b\u5169\u90e8\u5206\uff1a\u5176\u4e00\u662f\u8a55\u4f30BRII-179\u3001elebsiran\u8207PEG-IFN\u03b1\u4e09\u806f\u65b9\u6848\u540c\u671f\u7d66\u85e548\u5468\u7684\u6548\u679c\uff1b\u5176\u4e8c\u662f\u63a2\u7d22\u5e8f\u8cab\u65b9\u5f0f\u2014\u2014\u5148\u7528BRII-179\u548celebsiran\u6cbb\u764224\u5468\uff0c\u518d\u9032\u884c24\u9031\u4e09\u806f\u6cbb\u7642\uff0c\u5c0d\u7167\u7d44\u5247\u63a5\u53d748\u5468PEG-IFN\u03b1\u6cbb\u7642\u3002\u5169\u9805\u7814\u7a76\u5747\u5df2\u5b8c\u6210\u60a3\u8005\u62db\u52df\uff0c\u9810\u8a08\u5c07\u57282026\u5e74\u516c\u4f48EOT\u6578\u64da\u3002<\/p>\n<p>\u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u6b23\u559c\u5730\u770b\u5230\u5728EOT\u6642HBsAg\u6e05\u9664\u7387\u7684\u5dee\u7570\u572824\u5468\u96a8\u8a2a\u4e2d\u5f97\u4ee5\u4fdd\u6301\u3002\u9019\u4e9b\u7d50\u679c\u652f\u6301BRII-179\u5728\u5be6\u73fe\u66f4\u5feb\u901f\u3001\u66f4\u6301\u4e45HBsAg\u6e05\u9664\u53ca\u6f5b\u5728\u7e2e\u77edPEG-IFN\u03b1\u6cbb\u7642\u9031\u671f\u65b9\u9762\u7684\u6f5b\u529b\u3002\u6211\u5011\u671f\u5f85\u5728\u6b63\u5728\u9032\u884c\u7684\u9a57\u8b49\u6027\u7814\u7a76\u4e2d\u78ba\u8a8d\u9019\u4e9b\u767c\u73fe\u3002\u300d<\/p>\n<p><b>\u6458\u8981\u7de8\u865f\uff1a<\/b>5036<br \/><b>\u6a19\u984c\uff1a<\/b>\u65e2\u5f80\u63a5\u53d7BRII-179\u6cbb\u7642\u4e26\u7522\u751f\u61c9\u7b54\u7684\u6162\u6027\u4e59\u809d\u60a3\u8005\u5728elebsiran\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\u6cbb\u7642\u4e2d\u5be6\u73fe\u66f4\u9ad8\u6301\u7e8cHBsAg\u6e05\u9664\u7387\uff1aENSURE\u7814\u7a76\u96a8\u8a2a\u6578\u64da<br \/><b>\u5831\u544a\u4eba\uff1a<\/b>\u9ec3\u9e97\u8679\u6559\u6388\uff0cMBChB\uff08CUHK\uff09\uff0cMD\uff08CUHK\uff09\uff0cFRCP\uff08Lond, Edin\uff09\uff0cFHKCP\uff0cFHKAM\uff08Medicine\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u91ab\u5b78\u6578\u64da\u5206\u6790\u4e2d\u5fc3\uff08MDAC\uff09\u53ca\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u5167\u79d1\u53ca\u85e5\u7269\u6cbb\u7642\u5b78\u7cfb\u8178\u80c3\u53ca\u809d\u75c5\u79d1\u5c08\u79d1\u6559\u6388\uff0c\u4e2d\u570b\u9999\u6e2f\u7279\u5225\u884c\u653f\u5340<\/p>\n<ul type=\"disc\">\n<li>\u5171\u5206\u679031\u4f8b\u53c3\u8207\u8005\uff0c\u5176\u4e2d19\u4f8b\u70baBRII-179\u8a98\u5c0e\u7684\u6297-HBs\u61c9\u7b54\u8005\uff0c12\u4f8b\u70ba\u7121\u61c9\u7b54\u8005<\/li>\n<li>ENSURE\u7814\u7a76\u4e2d\u6297-HBs\u61c9\u7b54\u8005\u7684HBsAg\u57fa\u7dda\u4e2d\u4f4d\u6578[\u7bc4\u570d]\uff08520 [34-2165] IU\/mL\uff09\u8207\u7121\u61c9\u7b54\u8005\uff08185 [51-672] IU\/mL\uff09\u76f8\u6bd4\uff0c\u7d55\u5c0d\u6578\u503c\u66f4\u9ad8<\/li>\n<li>EOT\u5f8c\u7b2c24\u5468\uff0c\u6297-HBs\u61c9\u7b54\u8005HBsAg\u6e05\u9664\u7387\uff088\/19\uff0c42.1%\uff09\u986f\u8457\u9ad8\u65bc\u7121\u61c9\u7b54\u8005\uff081\/12\uff0c8.3%\uff09<\/li>\n<li>\u5118\u7ba1\u6240\u6709\u5be6\u73fe\u6301\u7e8cHBsAg\u6e05\u9664\u7684\u53c3\u8207\u8005\u5728ENSURE\u7814\u7a76HBsAg\u57fa\u7dda\u5747&lt;1,500 IU\/mL\uff0c\u4f468\u540d\u6297-HBs\u61c9\u7b54\u8005\u4e2d\u67094\u540d\uff0850.0%\uff09\u5728\u5148\u524d\u7814\u7a76\u4e2d\u5165\u7d44\u6642HBsAg\u57fa\u7dda\u6c34\u5e73\u57281,514-3,086 IU\/mL\u4e4b\u9593\uff0c\u8868\u660eBRII-179\u6709\u671b\u5728\u4e0d\u540cHBsAg\u57fa\u7dda\u6c34\u5e73\u7684\u60a3\u8005\u4e2d\u8a98\u5c0e\u6297-HBs\u61c9\u7b54<\/li>\n<li>Elebsiran\u806f\u5408PEG-IFN\u03b1\u6cbb\u7642\u7e3d\u9ad4\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d<\/li>\n<\/ul>\n<p><b>\u95dc\u65bc\u4e59\u578b\u809d\u708e<\/b><\/p>\n<p>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.54\u5104\u3002<sup>[1]<\/sup>\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002<sup>[1]<\/sup>\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002<sup>[2]<\/sup><\/p>\n<p><b>\u95dc\u65bcBRII-179<\/b><\/p>\n<p>BRII-179\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV \u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b542023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bcElebsiran<\/b><\/p>\n<p>Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV RNA\u8f49\u9304\u672c\u53ca\u9650\u5236\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7684\u7522\u751f\uff0c\u5176\u5177\u6709\u91dd\u5c0dHBV\u53ca\u4e01\u578b\u809d\u708e\u75c5\u6bd2\uff08HDV\uff09\u7684\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u5176\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u7a69\u5b9a\u5316\u5b78\u589e\u5f37\u6280\u8853\u7684siRNA\uff0c\u4ee5\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u6e1b\u5c11\u812b\u9776\u6d3b\u6027\uff0c\u5f9e\u800c\u6709\u53ef\u80fd\u63d0\u9ad8\u6cbb\u7642\u6307\u6578\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc. \u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002<\/p>\n<p><b>\u95dc\u65bc\u9a30\u76db\u535a\u85e5<\/b><\/p>\n<p>\u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7642\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7d66\u60a3\u8005\u5e36\u4f86\u56b4\u91cd\u793e\u6703\u6b67\u8996\u7684\u91cd\u5927\u516c\u5171\u885b\u751f\u6311\u6230\u958b\u767c\u5275\u65b0\u7642\u6cd5\u3002\u516c\u53f8\u5c08\u6ce8\u65bc\u611f\u67d3\u6027\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u9032\u4e00\u689d\u6db5\u84cb\u591a\u7a2e\u7368\u7279\u5019\u9078\u85e5\u7269\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u91cd\u9ede\u5305\u62ec\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u9818\u5148\u9805\u76ee\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u65bc\u7f85\u5229-\u9054\u52d2\u59c6\u3001\u820a\u91d1\u5c71\u7063\u5340\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u8853\u4e2d\u5fc3\u958b\u5c55\u696d\u52d9\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f\u00a0<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.briibio.com<\/a>\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prnsbtb1 prnrbrb1 prnsbbb1 prnsblb1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[1]<\/sup>\u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0<a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789240091672\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow\" style=\"color: #0000FF\">https:\/\/www.who.int\/publications\/i\/item\/9789240091672<\/a><\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><sup>[2]<\/sup>\u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0<a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow\" style=\"color: #0000FF\">https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u968a\u52174\u96a8\u8a2a\u6578\u64da\u986f\u793a\uff0c\u63a5\u53d7ele&#8230;<\/p>\n","protected":false},"author":16,"featured_media":380798,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-380797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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\u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054HBV\u7684Pre-S1\u3001Pre-S2\u548cS\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b542023\u5e7411\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88BRII-179\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bcElebsiran Elebsiran\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u7684\u5c0f\u5e72\u64fe\u6838\u7cd6\u6838\u9178\uff08siRNA\uff09\u7814\u7a76\u6027\u85e5\u7269\uff0c\u65e8\u5728\u964d\u89e3HBV 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\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 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         \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672 \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=380797\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9a30\u76db\u535a\u85e5\u57282025\u5e74AASLD\u5927\u6703\u4e0a\u767c\u4f48ENSURE II\u671f\u7814\u7a76\u6700\u65b0\u7a81\u7834\u6027\u6578\u64da\uff0c\u9032\u4e00\u6b65\u5f37\u8abfBRII-179\u4f5c\u70ba\u6162\u4e59\u809d\u6cbb\u7652\u6027\u7642\u6cd5\u7684\u6f5b\u529b - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u968a\u52174\u96a8\u8a2a\u6578\u64da\u986f\u793a\uff0c\u63a5\u53d7elebsiran\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u6cbb\u7642\u7684BRII-179\u6297-HBs\u61c9\u7b54\u8005\uff0c\u5728\u6cbb\u7642\u7d50\u675f\uff08EOT\uff09\u5f8c24\u5468\u4ecd\u7dad\u6301HBsAg\u6e05\u9664\u72c0\u614b\u3002  \u6578\u64da\u8868\u660e\uff0cBRII-179\u6297-HBs\u61c9\u7b54\u8005HBsAg\u4e0b\u964d\u901f\u5ea6\u66f4\u5feb\u3001\u5e45\u5ea6\u66f4\u5927\uff0c\u9019\u70ba\u7e2e\u77edPEG-IFN\u03b1\u6cbb\u7642\u9031\u671f\u63d0\u4f9b\u4e86\u53ef\u80fd\u3002  \u4e2d\u570b\u5317\u4eac\u548c\u7f8e\u570b\u5317\u5361\u7f85\u840a\u7d0d\u5dde\u9054\u52d2\u59c6\u5e022025\u5e7411\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- 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         \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672 \u00a0World Health Organization. Hepatitis. World Health Organization. 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\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 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         \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672 \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.         \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=380797","og_locale":"zh_TW","og_type":"article","og_title":"\u9a30\u76db\u535a\u85e5\u57282025\u5e74AASLD\u5927\u6703\u4e0a\u767c\u4f48ENSURE II\u671f\u7814\u7a76\u6700\u65b0\u7a81\u7834\u6027\u6578\u64da\uff0c\u9032\u4e00\u6b65\u5f37\u8abfBRII-179\u4f5c\u70ba\u6162\u4e59\u809d\u6cbb\u7652\u6027\u7642\u6cd5\u7684\u6f5b\u529b - 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\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316elebsiran\u7684\u7368\u5bb6\u6b0a\u76ca\u30022024\u5e745\u6708\uff0c\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u85e5\u54c1\u5be9\u8a55\u4e2d\u5fc3\uff08CDE\uff09\u6388\u4e88elebsiran\u7a81\u7834\u6027\u7642\u6cd5\u8a8d\u5b9a\u3002 \u95dc\u65bc\u9a30\u76db\u535a\u85e5 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         \u00a0World Health Organization. (April 2024). Global hepatitis report 2024: action for access in low- and middle-income countries. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/publications\/i\/item\/9789240091672 \u00a0World Health Organization. Hepatitis. World Health Organization. Retrieved from\u00a0https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C.         \u00a0","og_url":"https:\/\/pingtungtimes.com.tw\/?p=380797","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2025-11-10T13:30:00+00:00","og_image":[{"width":1706,"height":960,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 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\u00a0World Health Organization. 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