{"id":378877,"date":"2025-11-05T08:10:00","date_gmt":"2025-11-05T00:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=378877"},"modified":"2025-11-05T08:10:00","modified_gmt":"2025-11-05T00:10:00","slug":"%e6%ad%8c%e7%a6%ae%e5%9c%a82025%e5%b9%b4%e8%82%a5%e8%83%96%e5%91%a8%ef%bc%88obesityweek%ef%bc%89%e5%a0%b1%e5%91%8aasc30%e5%8f%a3%e6%9c%8d%e7%89%87ib%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%9a%84%e5%ae%8c","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=378877","title":{"rendered":"\u6b4c\u79ae\u57282025\u5e74\u80a5\u80d6\u5468\uff08ObesityWeek\u00ae\uff09\u5831\u544aASC30\u53e3\u670d\u7247Ib\u671f\u7814\u7a76\u7684\u5b8c\u6574\u5206\u6790\u3001ASC30\u6ce8\u5c04\u5291Ib\u671f\u7814\u7a76\u4ee5\u53caASC31\u8207ASC47\u806f\u5408\u7528\u85e5\u81e8\u5e8a\u524d\u7814\u7a76"},"content":{"rendered":"<div>\n<p><i>-ASC30<\/i><i>\u53e3\u670d\u7247<\/i><i>Ib<\/i><i>\u671f\u7814\u7a76\u7684\u7a4d\u6975\u6578\u64da\u986f\u793a\uff0c\u5b89\u6170\u5291\u6821\u6e96\u5f8c\u7684\u5e73\u5747\u9ad4\u91cd\u4e0b\u964d\u9ad8\u9054<\/i><i>6.5%<\/i><i>\uff1b\u5728\u6240\u6709\u591a\u5291\u91cf\u905e\u589e\uff08<\/i><i>MAD<\/i><i>\uff09\u968a\u5217\u4e2d\u5747\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\uff0c\u50c5\u51fa\u73fe\u8f15\u81f3\u4e2d\u5ea6\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u3002<\/i><\/p>\n<p><i>-ASC30<\/i><i>\u76ae\u4e0b\u6ce8\u5c04\u5291<\/i><i>Ib<\/i><i>\u671f\u7814\u7a76\u6578\u64da\u986f\u793a\uff0c\u6cbb\u7642\u5236\u5291\uff08\u6ce8\u5c04\u5291<\/i><i>A<\/i><i>\uff09\u7684\u8868\u89c0\u534a\u8870\u671f\u9054<\/i><i>46<\/i><i>\u5929\uff0c\u7dad\u6301\u5236\u5291\uff08\u6ce8\u5c04\u5291<\/i><i>B<\/i><i>\uff09\u7684\u8868\u89c0\u534a\u8870\u671f\u9054<\/i><i>75<\/i><i>\u5929\u3002<\/i><\/p>\n<p><i>&#8211;<\/i><i>\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08<\/i><i>DIO<\/i><i>\uff09\u5c0f\u9f20\u7814\u7a76\u4e2d\uff0c<\/i><i>ASC47<\/i><i>\u8207<\/i><i>ASC31<\/i><i>\uff08\u65b0\u578b<\/i><i>GLP-1R<\/i><i>\u53ca<\/i><i>GIPR<\/i><i>\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff09\u7684\u806f\u5408\u7642\u6cd5\u5728\u6e1b\u91cd\u3001\u6e1b\u8102\u53ca\u4e0d\u6e1b\u808c\u65b9\u9762\u5747\u986f\u8457\u512a\u65bc\u66ff\u723e\u6cca\u80bd\u55ae\u85e5\u548c<\/i><i>ASC31<\/i><i>\u55ae\u85e5\u7642\u6cd5\u3002<\/i><\/p>\n<p><i>&#8211;<\/i><i>\u9019\u4e9b\u5831\u544a\u9032\u4e00\u6b65\u5f70\u986f\u4e86\u6b4c\u79ae\u591a\u5143\u5316\u80a5\u80d6\u75c7\u7ba1\u7dda\u826f\u597d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7279\u5fb5\uff0c\u540c\u6642\u4e5f\u5370\u8b49\u4e86\u6b4c\u79ae\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684<\/i><i>AI<\/i><i>\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08<\/i><i>AISBDD<\/i><i>\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08<\/i><i>ULAP<\/i><i>\uff09\u7684\u6280\u8853\u3002<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u9999\u6e2f<\/span><span class=\"legendSpanClass\">2025\u5e7411\u67085\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 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1\uff08n=7\uff0c20\u6beb\u514b\uff09\u4e0b\u964d4.3%\uff0c\u5b89\u6170\u5291\u7d44\uff08n=6\uff09\u589e\u52a00.2%\u3002\u5728\u7b2c29\u5929\u672a\u89c0\u5bdf\u5230\u6e1b\u91cd\u5e73\u53f0\u671f\u3002MAD 3\uff08n=7\uff0c60\u6beb\u514b\uff09\u76f8\u5c0d\u57fa\u7dda\u9ad4\u91cd\u4e0b\u964d4.8%\uff0c\u6b64\u968a\u5217\u9ad4\u91cd\u4e0b\u964d\u5e45\u5ea6\u6700\u9ad8\u90549.3%\u3002\u82e5\u5254\u9664\u5169\u4f8b\u7570\u5e38\u503c\uff0cMAD 3\u76f8\u5c0d\u57fa\u7dda\u5e73\u5747\u9ad4\u91cd\u4e0b\u964d\u70ba5.9%\u3002<\/p>\n<p><b>\u80c3\u8178\u9053\u8010\u53d7\u6027<\/b>\uff1a\u5728MAD\u7814\u7a76\u4e2d\uff0cMAD 1\uff0820\u6beb\u514b\u968a\u5217\uff09\u672a\u51fa\u73fe\u5614\u5410\uff0c\u800cMAD 2\uff0840\u6beb\u514b\u968a\u5217\uff09\u51fa\u73fe\u5614\u5410\u3002\u5728MAD 1\u4e2d\u5f9e2\u6beb\u514b\u6ef4\u5b9a\uff08<span id=\"spanHghlt02ab\">titratin<\/span>g\uff09\u81f35\u6beb\u514b\u6642\u672a\u5f15\u767c\u5614\u5410\uff0c\u4f46\u5728MAD 2\u4e2d\u5f9e2\u6beb\u514b\u6ef4\u5b9a\u81f310\u6beb\u514b\u6642\u51fa\u73fe\u4e86\u5614\u5410\u3002\u8207MAD 2\u76f8\u6bd4\uff0c MAD 3\u5728\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u7684\u56b4\u91cd\u7a0b\u5ea6\u6216\u767c\u751f\u7387\u5747\u672a\u5448\u73fe\u5347\u9ad8\u8da8\u52e2\uff0c\u5118\u7ba1\u6709\u5169\u4f8b\u53d7\u8a66\u8005\u56e0\u4e3b\u8981\u7814\u7a76\u8005\u6c7a\u5b9a\u800c\u505c\u85e5\u3001\u4ee5\u53ca<span id=\"spanHghlt4f00\">\u4e00\u4f8b\u53d7\u8a66\u8005<\/span>\u56e0\u81ea\u884c\u9000\u51fa\u800c\u505c\u85e5\u3002<\/p>\n<p><b>\u5b89\u5168\u6027\uff1a<\/b>\u672a\u89c0\u5bdf\u5230\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62163\u7d1a\u53ca\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\uff08\u5305\u62ec\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\uff09\u3002\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u751f\u547d\u9ad4\u5f81\u3001\u5fc3\u96fb\u5716\uff08QTc\u9593\u671f\uff09\u53ca\u9ad4\u683c\u6aa2\u67e5\u5747\u6b63\u5e38\u3002\u5728\u6240\u6709MAD\u968a\u5217\u4e2d\u5747\u672a\u6aa2\u6e2c\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/p>\n<p><b>\u7d50\u8ad6\uff1a<\/b>ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247\u986f\u793a\uff0c\u7d9328\u5929\u6cbb\u7642\u5f8c\uff0c\u5b89\u6170\u5291\u6821\u6e96\u5f8c\u7684\u76f8\u5c0d\u57fa\u7dda\u7684\u5e73\u5747\u9ad4\u91cd\u4e0b\u964d\u9ad8\u90546.5%\u3002\u6700\u9ad8\u5291\u91cf\u7d44\uff08MAD 3\uff0c60\u6beb\u514b\uff09\u9ad4\u91cd\u4e0b\u964d\u5e45\u5ea6\u6700\u9ad8\u90549.3%\uff0c\u4e14\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u7684\u56b4\u91cd\u7a0b\u5ea6\u53ca\u767c\u751f\u7387\u672a\u5448\u73fe\u5347\u9ad8\u8da8\u52e2\u3002\u5728\u6240\u6709MAD\u968a\u5217\u4e2d\uff0cASC30\u50c5\u51fa\u73fe\u8f15\u81f3\u4e2d\u5ea6\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\uff0c\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u8207\u8010\u53d7\u6027\u3002ASC30\u7247\u7684\u5b89\u5168\u6027\u7279\u5fb5\u8207GLP-1R\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u7684\u4e00\u81f4\u6216\u66f4\u512a\u3002<\/p>\n<p><b>\u6458\u8981\u6a19\u984c\uff1a<\/b>ASC30\uff0c\u5728\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\uff1aIb\u671f\u7814\u7a76<\/p>\n<p><b>\u7d50\u679c\uff1a<\/b>ASC30\u76ae\u4e0b\u6cbb\u7642\u5236\u5291\uff08\u6ce8\u5c04\u5291A\uff09\u7684\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff0c\u6307ASC30\u8840\u85e5\u6fc3\u5ea6\u4e0b\u964d\u81f3\u5cf0\u503c\u768450%\u6240\u9700\u7684\u6642\u9593\uff09\u905446\u5929\uff0c\u800cASC30\u76ae\u4e0b\u7dad\u6301\u5236\u5291\uff08\u6ce8\u5c04\u5291B\uff09\u7684\u8868\u89c0\u534a\u8870\u671f\u905475\u5929\u3002\u6cbb\u7642\u5236\u5291\u7684\u5cf0\u6fc3\u5ea6\u8207\u7b2c29\u5929\u7684\u6fc3\u5ea6\u6bd4\u503c\uff08C<sub>max<\/sub>-to-C<sub>day29<\/sub>\uff09\u70ba1.5:1\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\uff1b\u7dad\u6301\u5236\u5291\u7684\u5cf0\u6fc3\u5ea6\u8207\u7b2c85\u5929<span id=\"spanHghlt9767\">\u7684<\/span>\u6fc3\u5ea6\u6bd4\u503c\uff08C<sub>max<\/sub>-to-C<sub>day85<\/sub>\uff09\u70ba2.5:1\uff0c\u5247\u652f\u6301\u6bcf\u5b63\u5ea6\u4e00\u6b21\u7d66\u85e5\u3002<\/p>\n<p>\u672a\u89c0\u5bdf\u5230\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62163\u7d1a\u53ca\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u3002\u80c3\u8178\u9053\u4e0d\u826f\u4e8b\u4ef6\u70ba\u8f15\u81f3\u4e2d\u5ea6\u3002\u5be6\u9a57\u5ba4\u6aa2\u67e5\u3001\u751f\u547d\u9ad4\u5f81\u3001\u5fc3\u96fb\u5716\uff08QTc\u9593\u671f\uff09\u53ca\u9ad4\u683c\u6aa2\u67e5\u5747\u6b63\u5e38\u3002\u6240\u6709\u968a\u5217\u5747\u672a\u6aa2\u6e2c\u5230\u809d\u81df\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/p>\n<p>ASC30\u8d85\u9577\u6548\u7de9\u91cb\u76ae\u4e0b\u5132\u5eab\u578b\uff08depot\uff09\u5236\u5291\u986f\u793a\u51fa46\u5929\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u6cbb\u7642\u5236\u5291\uff09\u820775\u5929\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u7dad\u6301\u5236\u5291\uff09\uff0c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u7684\u6cbb\u7642\u65b9\u6848\u8207\u6bcf\u5b63\u5ea6\u4e00\u6b21\u7684\u7dad\u6301\u65b9\u6848\u3002<\/p>\n<p>ASC30\u76ae\u4e0b\u5236\u5291\u8010\u53d7\u6027\u826f\u597d\uff0c\u50c5\u51fa\u73fe\u8f15\u81f3\u4e2d\u5ea6\u6cbb\u7642\u671f\u9593\u767c\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08treatment-emergent adverse event\uff0cTEAE\uff09\uff0c\u9019\u8207\u5728\u5176\u5b83GLP-1R\u6fc0\u52d5\u5291\u4e2d\u89c0\u5bdf\u5230\u7684\u7d50\u679c\u76f8\u6bd4\uff0c\u76f8\u7576\u6216\u66f4\u512a\u3002\u57fa\u65bc\u6b4c\u79ae\u8d85\u9577\u6548\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u958b\u767c\u7684ASC30\u6cbb\u7642\u5236\u5291\u8207\u7dad\u6301\u5236\u5291\uff0c\u901a\u904e\u63d0\u5347\u6cbb\u7642\u4fbf\u6377\u6027\u3001\u7528\u85e5\u4f9d\u5f9e\u6027\u548c\u751f\u6d3b\u8cea\u91cf\uff0c\u6709\u671b\u70ba\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u5e36\u4f86\u7a81\u7834\u6027\u9032\u5c55\u3002<\/p>\n<p><b>\u6458\u8981\u6a19\u984c\uff1a<\/b>GLP-1R<span id=\"spanHghlt8058\">\/GIPR\u6fc0\u52d5\u5291<\/span>\u591a\u80bdASC31+ASC47\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8f03\u66ff\u723e\u6cca\u80bd\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347119.6%<\/p>\n<p><b>\u7d50\u679c\uff1a<\/b>ASC47\u8207ASC31\u806f\u7528\u4f7f\u9ad4\u91cd\u4e0b\u964d44.8%\uff0c\u800cASC31\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d19.1%\uff0c\u806f\u5408\u7528\u85e5\u8f03\u55ae\u85e5\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347134%\u3002ASC47\u8207\u66ff\u723e\u6cca\u80bd\u806f\u7528\u4f7f\u9ad4\u91cd\u4e0b\u964d38.1%\uff0c\u800c\u66ff\u723e\u6cca\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d20.4%\uff0c\u806f\u5408\u7528\u85e5\u8f03\u66ff\u723e\u6cca\u80bd\u55ae\u85e5\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u534787%\u3002ASC31\u8207ASC47\u806f\u7528\u8f03ASC31\u55ae\u85e5\u7684\u5e73\u5747\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\uff08134%\uff09\u512a\u65bc\u66ff\u723e\u6cca\u80bd\u8207ASC47\u806f\u7528\u8f03\u66ff\u723e\u6cca\u80bd\u55ae\u85e5\u7684\u5e73\u5747\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\uff0887%\uff09\uff0c\u5169\u8005\u7684\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u3002<\/p>\n<p><b>\u7d50\u8ad6\uff1a<\/b>ASC47\u8207ASC31\u806f\u5408\u7642\u6cd5\u5728\u6e1b\u91cd\u3001\u6e1b\u8102\u53ca\u4e0d\u6e1b\u808c\u65b9\u9762\u5747\u986f\u8457\u512a\u65bc\u66ff\u723e\u6cca\u80bd\u55ae\u85e5\u548cASC31\u55ae\u85e5\u7642\u6cd5\u3002ASC47\u5206\u5225\u8207ASC31\u6216\u66ff\u723e\u6cca\u80bd\u806f\u7528\u5f8c\uff0c\u5747\u80fd\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002ASC31\u662f\u4e00\u6b3eGLP-1R\u53caGIPR\u96d9\u9776\u9ede\u591a\u80bd\u6fc0\u52d5\u5291\u3002ASC47\u662f\u4e00\u6b3e\u5c0f\u5206\u5b50\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u6fc0\u52d5\u5291\uff0c\u6191\u501f\u5176\u7368\u7279\u5dee\u7570\u5316\u7279\u6027\uff0c\u53ef\u5be6\u73fe\u8102\u80aa\u7d44\u7e54\u9776\u5411\u905e\u9001\u3002<\/p>\n<p>\u57282025\u5e74ObesityWeek<sup>\u00ae<\/sup>\u4e0a\u5831\u544a\u7684\u8a73\u7d30\u6578\u64da\u898b\u6b4c\u79ae\u7db2\u7ad9\uff08<a href=\"https:\/\/www.ascletis.com\/single\/191\/l\/zh-cn.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">\u93c8\u63a5<\/a>\uff09\u3002<\/p>\n<p>\u300c\u9019\u4e9b\u5831\u544a\u5f70\u986f\u4e86\u6b4c\u79ae\u5c0f\u5206\u5b50\u53ca\u591a\u80bd\u7684\u591a\u5143\u5316\u80a5\u80d6\u75c7\u7ba1\u7dda\u4ee4\u4eba\u632f\u596e\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7279\u5fb5\uff0c\u540c\u6642\u4e5f\u5370\u8b49\u4e86\u6b4c\u79ae\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08AISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08ULAP\uff09\u7684\u6280\u8853\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300c\u5728\u63a8\u9032ASC30\u3001ASC31\u53caASC47\u81e8\u5e8a\u958b\u767c\u7684\u540c\u6642\uff0c\u6211\u5011\u6301\u7e8c\u805a\u7126\u8207\u6230\u7565\u5925\u4f34\u7684\u7dca\u5bc6\u78cb\u5546\uff0c\u4ee5\u78ba\u4fdd\u6b4c\u79ae\u80fd\u66f4\u597d\u5730\u6eff\u8db3\u5168\u7403\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u6cbb\u7642\u9700\u6c42\u3002\u300d<\/p>\n<p><b>\u95dc\u65bc<\/b><b>ASC30<\/b><\/p>\n<p>ASC30\u662f\u4e00\u6b3e\u6b63\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u540c\u4e00\u5c0f\u5206\u5b50\u540c\u6642\u9069\u7528\u65bc\u53e3\u670d\u7247\u5291\u548c\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002ASC30\u662f\u4e00\u7a2e\u65b0\u5316\u5b78\u5be6\u9ad4\uff08NCE\uff09\uff0c\u64c1\u6709\u7f8e\u570b\u548c\u5168\u7403\u5316\u5408\u7269\u5c08\u5229\u4fdd\u8b77\uff0c\u5c08\u5229\u4fdd\u8b77\u671f\u81f32044\u5e74\uff08\u4e0d\u542b\u5c08\u5229\u5ef6\u671f\uff09\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>ASC31<\/b><\/p>\n<p>ASC31\u662f\u4e00\u6b3e\u7531\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578bGLP-1R\u548cGIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u540c\u6642\u986f\u793a\u51fa\u7a4d\u6975\u7684\u9ad4\u5916\u6d3b\u6027\u4e26\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u4e2d\u986f\u793a\u51fa\u7a4d\u6975\u7684\u9ad4\u5167\u7642\u6548\u3002ASC31\u9ad4\u73fe\u4e86\u6b4c\u79ae\u61c9\u7528\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u81ea\u4e3b\u7814\u767c\u65b0\u578b\u76ae\u4e0b\u6ce8\u5c04\u591a\u80bd\u548c\u53e3\u670d\u591a\u80bd\u7684\u90e8\u5206\u6210\u679c\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>ASC47<\/b><\/p>\n<p>ASC47\u662f\u4e00\u6b3e\u7531\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u3001\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684THR\u03b2\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002<\/p>\n<p><b>\u95dc<\/b><b>\u65bc\u6b4c<\/b><b>\u79ae<\/b><b>\u5236<\/b><b>\u85e5<\/b><b>\u6709\u9650\u516c\u53f8<\/b><\/p>\n<p>\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76ee\uff1aASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002<\/p>\n<p>\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1a<a href=\"http:\/\/www.ascletis.com\/\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">www.ascletis.com<\/a>\u3002<\/p>\n<p>\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n<p><span class=\"xn-person\">Peter Vozzo<\/span><br \/>ICR Healthcare<br \/>443-231-0505 (\u7f8e\u570b)<br \/><a href=\"mailto:Peter.vozzo@icrhealthcare.com\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">Peter.vozzo@icrhealthcare.com<\/a><\/p>\n<p>\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a<br \/>+86-181-0650-9129 (\u4e2d\u570b)<br \/><a href=\"mailto:pr@ascletis.com\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">pr@ascletis.com<\/a><br \/><a href=\"mailto:ir@ascletis.com\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">ir@ascletis.com<\/a>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>-ASC30\u53e3\u670d\u7247Ib\u671f\u7814\u7a76\u7684&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-378877","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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ASC31\u662f\u4e00\u6b3e\u7531\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578bGLP-1R\u548cGIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u540c\u6642\u986f\u793a\u51fa\u7a4d\u6975\u7684\u9ad4\u5916\u6d3b\u6027\u4e26\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u4e2d\u986f\u793a\u51fa\u7a4d\u6975\u7684\u9ad4\u5167\u7642\u6548\u3002ASC31\u9ad4\u73fe\u4e86\u6b4c\u79ae\u61c9\u7528\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u81ea\u4e3b\u7814\u767c\u65b0\u578b\u76ae\u4e0b\u6ce8\u5c04\u591a\u80bd\u548c\u53e3\u670d\u591a\u80bd\u7684\u90e8\u5206\u6210\u679c\u3002 \u95dc\u65bcASC47 ASC47\u662f\u4e00\u6b3e\u7531\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u3001\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684THR\u03b2\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76ee\uff1aASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u570b)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 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ASC31\u662f\u4e00\u6b3e\u7531\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578bGLP-1R\u548cGIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\u591a\u80bd\uff0c\u5728\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u4e2d\u986f\u793a\u51fa\u826f\u597d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5fb5\uff0c\u540c\u6642\u986f\u793a\u51fa\u7a4d\u6975\u7684\u9ad4\u5916\u6d3b\u6027\u4e26\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5c0f\u9f20\u4e2d\u986f\u793a\u51fa\u7a4d\u6975\u7684\u9ad4\u5167\u7642\u6548\u3002ASC31\u9ad4\u73fe\u4e86\u6b4c\u79ae\u61c9\u7528\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u81ea\u4e3b\u7814\u767c\u65b0\u578b\u76ae\u4e0b\u6ce8\u5c04\u591a\u80bd\u548c\u53e3\u670d\u591a\u80bd\u7684\u90e8\u5206\u6210\u679c\u3002 \u95dc\u65bcASC47 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