{"id":378547,"date":"2025-11-04T11:23:00","date_gmt":"2025-11-04T03:23:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=378547"},"modified":"2025-11-04T11:23:00","modified_gmt":"2025-11-04T03:23:00","slug":"%e3%80%902025-ash%e3%80%91-%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91%e5%88%a9%e6%b2%99%e6%89%98%e5%85%8b%e6%8b%89%e5%85%a9%e9%a0%85%e8%87%a8%e5%ba%8a%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=378547","title":{"rendered":"\u30102025 ASH\u3011 \u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291\u5229\u6c99\u6258\u514b\u62c9\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u5165\u9078\uff0c\u542b1\u9805\u53e3\u982d\u5831\u544a\uff01"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2025\u5e7411\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u539f\u52751\u985e\u65b0\u85e5\u5229\u6c99\u6258\u514b\u62c9\uff08\u5546\u54c1\u540d\uff1a\u5229\u751f\u59a5R\uff1b\u7814\u767c\u4ee3\u78bc\uff1aAPG-2575\uff09\u5171\u67092\u9805\u81e8\u5e8a\u9032\u5c55\u7372\u9078\u7b2c67\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\uff0c\u5176\u4e2d\u4e00\u9805\u7372\u53e3\u982d\u5831\u544a\u3002\u9019\u662f\u8a72\u54c1\u7a2e\u7684\u81e8\u5e8a\u9032\u5c55\u9023\u7e8c\u7b2c4\u5e74\u5165\u9078ASH\u5e74\u6703\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4eca\u5e74\u516c\u53f83\u500b\u54c1\u7a2e\uff08\u5229\u751f\u59a5R\u3001\u8010\u7acb\u514bR\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\u3002<\/span><\/p>\n

\n<\/p><\/div>\n

\u5229\u6c99\u6258\u514b\u62c9\u662f\u4e9e\u76db\u91ab\u85e5\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u53e3\u670dBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2e\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u7624\u6cbb\u7642\u9818\u57df\u5177\u5099\u5ee3\u95ca\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u8a72\u54c1\u7a2e\u5df2\u5728\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u7528\u65bc\u65e2\u5f80\u7d93\u904e\u81f3\u5c11\u5305\u542b\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5291\u5728\u5167\u7684\u4e00\u7a2e\u7cfb\u7d71\u6cbb\u7642\u7684\u6210\u4eba\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u5728\u6b64\u6b21ASH\u5e74\u6703\u4e0a\uff0c\u53e3\u982d\u5831\u544a\u8a72\u54c1\u7a2e\u55ae\u85e5\u6cbb\u7642\u5fa9\u767c\/\u96e3\u6cbb\u6027\uff08R\/R\uff09CLL\/SLL\u60a3\u8005\u7684\u6ce8\u518aII\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002\u6b64\u5916\uff0c\u5176\u806f\u5408\u963f\u624e\u80de\u7518\uff08AZA\uff09\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u7dad\u5948\u6258\u514b\u7d93\u6cbb\u9ad3\u7cfb\u816b\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u6578\u64da\u4e5f\u5c07\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u3002<\/span><\/p>\n

\u4e00\u5e74\u4e00\u5ea6\u7684ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5168\u9762\u6db5\u84cb\u4e86\u8840\u6db2\u75be\u75c5\u7684\u75c5\u56e0\u7814\u7a76\u548c\u6cbb\u7642\u7814\u7a76\u3002\u7b2c67\u5c46ASH\u5e74\u6703\u5c07\u65bc\u7576\u5730\u6642\u95932025\u5e7412\u67086\u65e5\u81f39\u65e5\u9593\u5728\u7f8e\u570b\u4f5b\u7f85\u88e1\u9054\u5dde\u5967\u862d\u591a\u5e02\u4ee5\u7dda\u4e0b\u7d50\u5408\u7dda\u4e0a\u7684\u5f62\u5f0f\u8209\u884c\u3002<\/span><\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u6b64\u524d\uff0c\u5229\u6c99\u6258\u514b\u62c9\u5df2\u7d93\u5728\u7642\u6548\u548c\u5b89\u5168\u6027\u65b9\u9762\u986f\u793a\u51fa\u4e86\u986f\u8457\u512a\u52e2\u3002\u8a72\u54c1\u7a2e\u76ee\u524d\u6b63\u5728\u958b\u5c55\u56db\u9805\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u6b64\u6b21\u5229\u6c99\u6258\u514b\u62c9\u7684\u81e8\u5e8a\u9032\u5c55\u518d\u6b21\u5165\u9078ASH\u5e74\u6703\u5831\u544a\uff0c\u4e14\u6709\u4e00\u9805\u7372\u53e3\u982d\u5831\u544a\uff0c\u9032\u4e00\u6b65\u9ad4\u73fe\u5176\u5728\u8840\u6db2\u816b\u7624\u9818\u57df\u5f37\u52c1\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u6b64\u5916\uff0c\u5f88\u9ad8\u8208\u4eca\u5e74\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u6709\u591a\u9805\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5145\u5206\u986f\u73fe\u4e86\u516c\u53f8\u7684\u5168\u7403\u5275\u65b0\u548c\u958b\u767c\u5be6\u529b\u3002\u6211\u5011\u671f\u5f85\u5728\u5f8c\u7e8c\u6703\u8b70\u671f\u9593\u8207\u5927\u5bb6\u5206\u4eab\u76f8\u95dc\u7814\u7a76\u7684\u8a73\u5be6\u6578\u64da\u3002\u672a\u4f86\uff0c\u4e9e\u76db\u91ab\u85e5\u5c07\u9032\u4e00\u6b65\u52a0\u901f\u63a8\u9032\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u70ba\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/span><\/p>\n

ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a<\/span><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u5c55\u793a\u5f62\u5f0f<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

\u54c1\u7a2e<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

\u6458\u8981\u6a19\u984c<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

\u7de8\u865f\u00a0<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u53e3\u982d\u5831\u544a<\/span><\/p>\n<\/td>\n

\n

\u5229\u6c99\u6258\u514b\u62c9<\/span><\/p>\n

\uff08APG-2575\uff09<\/span><\/p>\n<\/td>\n

\n

Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton’s tyrosine kinase inhibitors (BTKis)<\/span><\/p>\n

\u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c<\/span><\/p>\n<\/td>\n

\n

88<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u58c1\u5831\u5c55\u793a\u00a0<\/span><\/p>\n<\/td>\n

\n

\u5229\u6c99\u6258\u514b\u62c9\u00a0<\/span><\/p>\n

\uff08APG-2575\uff09<\/span><\/p>\n<\/td>\n

\n

Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies<\/span><\/p>\n

\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c<\/span><\/p>\n<\/td>\n

\n

1641<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5967\u96f7\u5df4\u66ff\u5c3c<\/span><\/p>\n

\uff08HQP1351\uff09<\/span><\/p>\n<\/td>\n

\n

Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL)<\/span><\/p>\n

\u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c<\/span><\/p>\n<\/td>\n

\n

1574<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations<\/span><\/p>\n

\u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f<\/span><\/p>\n<\/td>\n

\n

3788<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML)<\/span><\/p>\n

\u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da<\/span><\/p>\n<\/td>\n

<\/td>\n<\/tr>\n
\n

Preclinical and clinical Study of olverembatinib in patients with myeloid\/lymphoid neoplasms with FGFR1 rearrangement<\/span><\/p>\n

\u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\/\u6dcb\u5df4\u816b\u7624<\/span><\/p>\n<\/td>\n

\n

1979<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report<\/span><\/p>\n

\u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a<\/span><\/p>\n<\/td>\n

\n

1999<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial<\/span><\/p>\n

\u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76<\/span><\/p>\n<\/td>\n

\n

3779<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy<\/span><\/p>\n

\u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81<\/span><\/p>\n<\/td>\n

\n

5561<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

APG-5918<\/span><\/p>\n<\/td>\n

\n

Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM)<\/span><\/p>\n

\u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9<\/span><\/p>\n<\/td>\n

\n

1528<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5728\u7dda\u767c\u5e03<\/span><\/p>\n<\/td>\n

\n

\u5967\u96f7\u5df4\u66ff\u5c3c<\/span><\/p>\n

\uff08HQP1351\uff09<\/span><\/p>\n<\/td>\n

\n

Single CAR-t infusion during front-line consolidation induces deep and sustained remission
in newly diagnosed adult ph+b- ALL: A prospective phase 2 study<\/span><\/p>\n

\u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002<\/span><\/p>\n<\/td>\n

\n

442<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5229\u6c99\u6258\u514b\u62c9<\/span><\/p>\n

\uff08APG-2575\uff09<\/span><\/p>\n<\/td>\n

\n

BCL-2 inhibition in North American adult T-cell leukemia\/lymphoma: Preclinical insights
and early clinical outcomes<\/span><\/p>\n

BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c<\/span><\/p>\n<\/td>\n

\n

3304<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09<\/span><\/p>\n

\u53e3\u982d\u5831\u544a<\/span><\/b><\/u><\/p>\n

Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton’s tyrosine kinase inhibitors (BTKis)<\/span><\/b><\/p>\n

\u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c<\/span><\/b><\/p>\n

\u5c55\u793a\u5f62\u5f0f<\/b>\uff1a\u53e3\u982d\u5831\u544a
\u6458\u8981\u7de8\u865f<\/b>\uff1a88
\u5206\u6703\u5834<\/b>\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642
<\/span>\u5831\u544a\u6642\u9593<\/b>\uff1a
2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff09
2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09
\u7b2c\u4e00\u4f5c\u8005<\/b>\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388
\u5831\u544a\u4eba<\/b>\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388<\/span><\/p>\n

\u6838\u5fc3\u8981\u9ede\uff1a<\/span><\/b><\/p>\n

\u8a72\u7814\u7a76\uff08NCT05147467\uff09\u662f\u4e00\u9805\u91dd\u5c0d\u5fa9\u767c\/\u96e3\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7684\u95dc\u9375\u6ce8\u518aII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u3002\u5165\u7d44\u60a3\u8005\u70baBTK\u6291\u5236\u5291\u548c\u514d\u75ab\u5316\u7642\u5747\u96e3\u6cbb\u3001\u5fa9\u767c\u3001\u6216\u4e0d\u8010\u53d7\uff1b\u6216\u4e00\u7dda\u4f7f\u7528BTK\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u4e14\u4e0d\u9069\u5408\u514d\u75ab\u5316\u7642\u7684\u60a3\u8005\u3002<\/span><\/p>\n

\u7642\u6548\u6578\u64da<\/u>\uff1a\u622a\u81f32025\u5e747\u670825\u65e5\uff0c\u572872\u4f8b\u53ef\u8a55\u4f30R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u7d93\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u8a55\u4f30\u78ba\u8a8d\u7684ORR\u70ba62.5%\u3002\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba23.89\u500b\u6708\uff08\u4e2d\u4f4d\u96a8\u8a2a22.01\u500b\u6708\uff09\u3002\u5728\u9ad8\u5371\u60a3\u8005\u7fa4\u9ad4\uff08\u651c\u5e36\u5982del(17p)\/TP53\u7a81\u8b8a\u3001\u5fa9\u96dc\u6838\u578b\u3001IGHV\u672a\u7a81\u8b8a\u7b49\u4e0d\u826f\u9810\u5f8c\u56e0\u7d20\uff09\u4e2d\uff0c\u6cbb\u7642\u986f\u793a\u51fa\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6df1\u5ea6\u7de9\u89e3\u300221.8%\u9054\u5230\u5916\u5468\u8840\u5fae\u5c0f\u6b98\u7559\u75c5\uff08MRD\uff09\u9670\u6027\u3002\u572811\u4f8b\u53ef\u8a55\u4f30\u9aa8\u9ad3MRD\u7684\u60a3\u8005\u4e2d\uff0c\u67096\u4f8b\u9054\u5230MRD\u9670\u6027\u3002<\/span><\/p>\n

\u5b89\u5168\u6027\u6578\u64da<\/u>\uff1a\u5229\u6c99\u6258\u514b\u62c9\u5728BTKi\u7d93\u6cbb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u6700\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u548c\u8ca7\u8840\u7b49\u3002\u672a\u89c0\u5bdf\u5230\u4efb\u4f55\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\uff08TLS\uff09\u75c5\u4f8b\uff0c\u4e14\u7121\u85e5\u7269\u76f8\u95dc\u6b7b\u4ea1\u4e8b\u4ef6\u767c\u751f\u3002<\/span><\/p>\n

\u7d50\u8ad6<\/u>\uff1a\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u7642\u6cd5\u5728\u5c0dBTK\u6291\u5236\u5291\u8010\u85e5\u7684\u3001\u91cd\u5ea6\u7d93\u6cbb\u7684R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002<\/span><\/p>\n

\u58c1\u5831\u5c55\u793a<\/span><\/b><\/u><\/p>\n

Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies<\/b><\/span><\/p>\n

\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c<\/b>
<\/span><\/p>\n

\u5c55\u793a\u5f62\u5f0f<\/b>\uff1a\u58c1\u5831\u5c55\u793a
\u6458\u8981\u7de8\u865f<\/b>\uff1a1641
\u5206\u6703\u5834<\/b>\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI
\u5831\u544a\u6642\u9593<\/b>\uff1a
2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff09
2025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09
\u7b2c\u4e00\u4f5c\u8005<\/b>\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb
\u5831\u544a\u4eba<\/b>\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb<\/span><\/p>\n

\u6838\u5fc3\u8981\u9ede\uff1a<\/span><\/b><\/p>\n

    \n
  • \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805I\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u5291\u91cf\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002<\/span><\/li>\n
  • \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002<\/span><\/li>\n<\/ul>\n

    \u7642\u6548\u6578\u64da<\/u>\uff1a\u622a\u81f32025\u5e747\u67081\u65e5\uff0c<\/span><\/p>\n

      \n
    • 47\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005\u7e3d\u6709\u6548\u7387\uff08ORR\uff09\u70ba40.4%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba29.8%\uff0814\/47\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768424\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba29.2% (7\/24)\uff0cCR\u7387\u70ba20.8%\uff085\/24\uff09\uff1b<\/span><\/li>\n
    • 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b<\/span><\/li>\n
    • R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b<\/span><\/li>\n
    • \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002<\/span><\/li>\n<\/ul>\n

      \u5b89\u5168\u6027\u6578\u64da<\/u>\uff1a\u7b2c1\u90e8\u5206\u5291\u91cf\u905e\u589e\u968e\u6bb5\u53ca\u7b2c2\u90e8\u5206\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u5747\u672a\u767c\u751f\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\u3002\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u904e\u7a0b\u4e2d\u767c\u751f\u7684\u4e0d\u826f\u53cd\u61c9\uff08TEAEs\uff09\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0841.7%\uff09\u3001\u767c\u71b1\u6027\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\uff0835.0%\uff09\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\uff0826.2%\uff09\u3001\u8ca7\u8840\uff0817.5%\uff09\u3002<\/span><\/p>\n

      \u7d50\u8ad6<\/u>\uff1a\u521d\u6b65\u81e8\u5e8a\u6578\u64da\u986f\u793a\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u7684\u6cbb\u7642\u65b9\u6848\u6709\u53ef\u80fd\u514b\u670d\u7dad\u5948\u514b\u62c9\u8010\u85e5\uff0c\u70baAML\/HR MDS\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u5e0c\u671b\u3002<\/span><\/p>\n

      \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/span><\/b><\/p>\n

      \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002<\/span><\/p>\n

      \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002<\/span><\/p>\n

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ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a \u5c55\u793a\u5f62\u5f0f \u54c1\u7a2e \u6458\u8981\u6a19\u984c \u7de8\u865f\u00a0 \u53e3\u982d\u5831\u544a \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c 88 \u58c1\u5831\u5c55\u793a\u00a0 \u5229\u6c99\u6258\u514b\u62c9\u00a0 \uff08APG-2575\uff09 Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c 1641 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) \u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c 1574 Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations \u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f 3788 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) \u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da Preclinical and clinical Study of olverembatinib in patients with myeloid\/lymphoid neoplasms with FGFR1 rearrangement \u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\/\u6dcb\u5df4\u816b\u7624 1979 Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report \u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a 1999 The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial \u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76 3779 Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81 5561 APG-5918 Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM) \u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9 1528 \u5728\u7dda\u767c\u5e03 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Single CAR-t infusion during front-line consolidation induces deep and sustained remissionin newly diagnosed adult ph+b- ALL: A prospective phase 2 study \u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002 442 \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 BCL-2 inhibition in North American adult T-cell leukemia\/lymphoma: Preclinical insightsand early clinical outcomes BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c 3304 \u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09 \u53e3\u982d\u5831\u544a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a88\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388\u5831\u544a\u4eba\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388 \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT05147467\uff09\u662f\u4e00\u9805\u91dd\u5c0d\u5fa9\u767c\/\u96e3\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7684\u95dc\u9375\u6ce8\u518aII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u3002\u5165\u7d44\u60a3\u8005\u70baBTK\u6291\u5236\u5291\u548c\u514d\u75ab\u5316\u7642\u5747\u96e3\u6cbb\u3001\u5fa9\u767c\u3001\u6216\u4e0d\u8010\u53d7\uff1b\u6216\u4e00\u7dda\u4f7f\u7528BTK\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u4e14\u4e0d\u9069\u5408\u514d\u75ab\u5316\u7642\u7684\u60a3\u8005\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u670825\u65e5\uff0c\u572872\u4f8b\u53ef\u8a55\u4f30R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u7d93\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u8a55\u4f30\u78ba\u8a8d\u7684ORR\u70ba62.5%\u3002\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba23.89\u500b\u6708\uff08\u4e2d\u4f4d\u96a8\u8a2a22.01\u500b\u6708\uff09\u3002\u5728\u9ad8\u5371\u60a3\u8005\u7fa4\u9ad4\uff08\u651c\u5e36\u5982del(17p)\/TP53\u7a81\u8b8a\u3001\u5fa9\u96dc\u6838\u578b\u3001IGHV\u672a\u7a81\u8b8a\u7b49\u4e0d\u826f\u9810\u5f8c\u56e0\u7d20\uff09\u4e2d\uff0c\u6cbb\u7642\u986f\u793a\u51fa\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6df1\u5ea6\u7de9\u89e3\u300221.8%\u9054\u5230\u5916\u5468\u8840\u5fae\u5c0f\u6b98\u7559\u75c5\uff08MRD\uff09\u9670\u6027\u3002\u572811\u4f8b\u53ef\u8a55\u4f30\u9aa8\u9ad3MRD\u7684\u60a3\u8005\u4e2d\uff0c\u67096\u4f8b\u9054\u5230MRD\u9670\u6027\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u5229\u6c99\u6258\u514b\u62c9\u5728BTKi\u7d93\u6cbb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u6700\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u548c\u8ca7\u8840\u7b49\u3002\u672a\u89c0\u5bdf\u5230\u4efb\u4f55\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\uff08TLS\uff09\u75c5\u4f8b\uff0c\u4e14\u7121\u85e5\u7269\u76f8\u95dc\u6b7b\u4ea1\u4e8b\u4ef6\u767c\u751f\u3002 \u7d50\u8ad6\uff1a\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u7642\u6cd5\u5728\u5c0dBTK\u6291\u5236\u5291\u8010\u85e5\u7684\u3001\u91cd\u5ea6\u7d93\u6cbb\u7684R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002 \u58c1\u5831\u5c55\u793a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a1641\u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb\u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805I\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u5291\u91cf\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002 \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u67081\u65e5\uff0c 47\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005\u7e3d\u6709\u6548\u7387\uff08ORR\uff09\u70ba40.4%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba29.8%\uff0814\/47\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768424\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba29.2% (7\/24)\uff0cCR\u7387\u70ba20.8%\uff085\/24\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002 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ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 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ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a \u5c55\u793a\u5f62\u5f0f \u54c1\u7a2e \u6458\u8981\u6a19\u984c \u7de8\u865f\u00a0 \u53e3\u982d\u5831\u544a \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c 88 \u58c1\u5831\u5c55\u793a\u00a0 \u5229\u6c99\u6258\u514b\u62c9\u00a0 \uff08APG-2575\uff09 Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c 1641 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) \u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c 1574 Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations \u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f 3788 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) \u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da Preclinical and clinical Study of olverembatinib in patients with myeloid\/lymphoid neoplasms with FGFR1 rearrangement \u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\/\u6dcb\u5df4\u816b\u7624 1979 Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report \u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a 1999 The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial \u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76 3779 Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81 5561 APG-5918 Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM) \u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9 1528 \u5728\u7dda\u767c\u5e03 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Single CAR-t infusion during front-line consolidation induces deep and sustained remissionin newly diagnosed adult ph+b- ALL: A prospective phase 2 study \u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002 442 \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 BCL-2 inhibition in North American adult T-cell leukemia\/lymphoma: Preclinical insightsand early clinical outcomes BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c 3304 \u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09 \u53e3\u982d\u5831\u544a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a88\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388\u5831\u544a\u4eba\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388 \u6838\u5fc3\u8981\u9ede\uff1a 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CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002 \u58c1\u5831\u5c55\u793a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a1641\u5206\u6703\u5834\uff1a616. 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ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a \u5c55\u793a\u5f62\u5f0f \u54c1\u7a2e \u6458\u8981\u6a19\u984c \u7de8\u865f\u00a0 \u53e3\u982d\u5831\u544a \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\\\/refractory chronic lymphocytic leukemia\\\/small lymphocytic lymphoma (CLL\\\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c 88 \u58c1\u5831\u5c55\u793a\u00a0 \u5229\u6c99\u6258\u514b\u62c9\u00a0 \uff08APG-2575\uff09 Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c 1641 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) \u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c 1574 Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations \u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f 3788 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) \u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da Preclinical and clinical Study of olverembatinib in patients with myeloid\\\/lymphoid neoplasms with FGFR1 rearrangement \u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\\\/\u6dcb\u5df4\u816b\u7624 1979 Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report \u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a 1999 The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial \u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76 3779 Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\\\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\\\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81 5561 APG-5918 Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\\\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM) \u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\\\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9 1528 \u5728\u7dda\u767c\u5e03 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Single CAR-t infusion during front-line consolidation induces deep and sustained remissionin newly diagnosed adult ph+b- ALL: A prospective phase 2 study \u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002 442 \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 BCL-2 inhibition in North American adult T-cell leukemia\\\/lymphoma: Preclinical insightsand early clinical outcomes BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\\\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c 3304 \u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09 \u53e3\u982d\u5831\u544a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\\\/refractory chronic lymphocytic leukemia\\\/small lymphocytic lymphoma (CLL\\\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a88\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388\u5831\u544a\u4eba\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388 \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT05147467\uff09\u662f\u4e00\u9805\u91dd\u5c0d\u5fa9\u767c\\\/\u96e3\u6cbb\u6027CLL\\\/SLL\u60a3\u8005\u7684\u95dc\u9375\u6ce8\u518aII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u3002\u5165\u7d44\u60a3\u8005\u70baBTK\u6291\u5236\u5291\u548c\u514d\u75ab\u5316\u7642\u5747\u96e3\u6cbb\u3001\u5fa9\u767c\u3001\u6216\u4e0d\u8010\u53d7\uff1b\u6216\u4e00\u7dda\u4f7f\u7528BTK\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u4e14\u4e0d\u9069\u5408\u514d\u75ab\u5316\u7642\u7684\u60a3\u8005\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u670825\u65e5\uff0c\u572872\u4f8b\u53ef\u8a55\u4f30R\\\/R CLL\\\/SLL\u60a3\u8005\u4e2d\uff0c\u7d93\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u8a55\u4f30\u78ba\u8a8d\u7684ORR\u70ba62.5%\u3002\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba23.89\u500b\u6708\uff08\u4e2d\u4f4d\u96a8\u8a2a22.01\u500b\u6708\uff09\u3002\u5728\u9ad8\u5371\u60a3\u8005\u7fa4\u9ad4\uff08\u651c\u5e36\u5982del(17p)\\\/TP53\u7a81\u8b8a\u3001\u5fa9\u96dc\u6838\u578b\u3001IGHV\u672a\u7a81\u8b8a\u7b49\u4e0d\u826f\u9810\u5f8c\u56e0\u7d20\uff09\u4e2d\uff0c\u6cbb\u7642\u986f\u793a\u51fa\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6df1\u5ea6\u7de9\u89e3\u300221.8%\u9054\u5230\u5916\u5468\u8840\u5fae\u5c0f\u6b98\u7559\u75c5\uff08MRD\uff09\u9670\u6027\u3002\u572811\u4f8b\u53ef\u8a55\u4f30\u9aa8\u9ad3MRD\u7684\u60a3\u8005\u4e2d\uff0c\u67096\u4f8b\u9054\u5230MRD\u9670\u6027\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u5229\u6c99\u6258\u514b\u62c9\u5728BTKi\u7d93\u6cbb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u6700\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u548c\u8ca7\u8840\u7b49\u3002\u672a\u89c0\u5bdf\u5230\u4efb\u4f55\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\uff08TLS\uff09\u75c5\u4f8b\uff0c\u4e14\u7121\u85e5\u7269\u76f8\u95dc\u6b7b\u4ea1\u4e8b\u4ef6\u767c\u751f\u3002 \u7d50\u8ad6\uff1a\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u7642\u6cd5\u5728\u5c0dBTK\u6291\u5236\u5291\u8010\u85e5\u7684\u3001\u91cd\u5ea6\u7d93\u6cbb\u7684R\\\/R CLL\\\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002 \u58c1\u5831\u5c55\u793a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a1641\u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb\u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805I\\\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\\\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u5291\u91cf\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002 \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\\\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\\\/\u96e3\u6cbb\uff09\uff0cHR MDS\\\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\\\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u67081\u65e5\uff0c 47\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\\\/\u96e3\u6cbb\u7684AML\\\/MPAL\u60a3\u8005\u7e3d\u6709\u6548\u7387\uff08ORR\uff09\u70ba40.4%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba29.8%\uff0814\\\/47\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768424\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\\\/R AML\\\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba29.2% (7\\\/24)\uff0cCR\u7387\u70ba20.8%\uff085\\\/24\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\\\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\\\/R AML\\\/MPAL\u6216R\\\/R HR MDS\\\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b \u521d\u6cbbAML\\\/MPAL\u6216\u521d\u6cbbHR MDS\\\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002 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ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a \u5c55\u793a\u5f62\u5f0f \u54c1\u7a2e \u6458\u8981\u6a19\u984c \u7de8\u865f\u00a0 \u53e3\u982d\u5831\u544a \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c 88 \u58c1\u5831\u5c55\u793a\u00a0 \u5229\u6c99\u6258\u514b\u62c9\u00a0 \uff08APG-2575\uff09 Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c 1641 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) \u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c 1574 Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations \u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f 3788 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) \u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da Preclinical and clinical Study of olverembatinib in patients with myeloid\/lymphoid neoplasms with FGFR1 rearrangement \u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\/\u6dcb\u5df4\u816b\u7624 1979 Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report \u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a 1999 The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial \u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76 3779 Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81 5561 APG-5918 Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM) \u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9 1528 \u5728\u7dda\u767c\u5e03 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Single CAR-t infusion during front-line consolidation induces deep and sustained remissionin newly diagnosed adult ph+b- ALL: A prospective phase 2 study \u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002 442 \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 BCL-2 inhibition in North American adult T-cell leukemia\/lymphoma: Preclinical insightsand early clinical outcomes BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c 3304 \u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09 \u53e3\u982d\u5831\u544a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a88\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388\u5831\u544a\u4eba\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388 \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT05147467\uff09\u662f\u4e00\u9805\u91dd\u5c0d\u5fa9\u767c\/\u96e3\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7684\u95dc\u9375\u6ce8\u518aII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u3002\u5165\u7d44\u60a3\u8005\u70baBTK\u6291\u5236\u5291\u548c\u514d\u75ab\u5316\u7642\u5747\u96e3\u6cbb\u3001\u5fa9\u767c\u3001\u6216\u4e0d\u8010\u53d7\uff1b\u6216\u4e00\u7dda\u4f7f\u7528BTK\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u4e14\u4e0d\u9069\u5408\u514d\u75ab\u5316\u7642\u7684\u60a3\u8005\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u670825\u65e5\uff0c\u572872\u4f8b\u53ef\u8a55\u4f30R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u7d93\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u8a55\u4f30\u78ba\u8a8d\u7684ORR\u70ba62.5%\u3002\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba23.89\u500b\u6708\uff08\u4e2d\u4f4d\u96a8\u8a2a22.01\u500b\u6708\uff09\u3002\u5728\u9ad8\u5371\u60a3\u8005\u7fa4\u9ad4\uff08\u651c\u5e36\u5982del(17p)\/TP53\u7a81\u8b8a\u3001\u5fa9\u96dc\u6838\u578b\u3001IGHV\u672a\u7a81\u8b8a\u7b49\u4e0d\u826f\u9810\u5f8c\u56e0\u7d20\uff09\u4e2d\uff0c\u6cbb\u7642\u986f\u793a\u51fa\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6df1\u5ea6\u7de9\u89e3\u300221.8%\u9054\u5230\u5916\u5468\u8840\u5fae\u5c0f\u6b98\u7559\u75c5\uff08MRD\uff09\u9670\u6027\u3002\u572811\u4f8b\u53ef\u8a55\u4f30\u9aa8\u9ad3MRD\u7684\u60a3\u8005\u4e2d\uff0c\u67096\u4f8b\u9054\u5230MRD\u9670\u6027\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u5229\u6c99\u6258\u514b\u62c9\u5728BTKi\u7d93\u6cbb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u6700\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u548c\u8ca7\u8840\u7b49\u3002\u672a\u89c0\u5bdf\u5230\u4efb\u4f55\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\uff08TLS\uff09\u75c5\u4f8b\uff0c\u4e14\u7121\u85e5\u7269\u76f8\u95dc\u6b7b\u4ea1\u4e8b\u4ef6\u767c\u751f\u3002 \u7d50\u8ad6\uff1a\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u7642\u6cd5\u5728\u5c0dBTK\u6291\u5236\u5291\u8010\u85e5\u7684\u3001\u91cd\u5ea6\u7d93\u6cbb\u7684R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002 \u58c1\u5831\u5c55\u793a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a1641\u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb\u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805I\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u5291\u91cf\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002 \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u67081\u65e5\uff0c 47\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005\u7e3d\u6709\u6548\u7387\uff08ORR\uff09\u70ba40.4%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba29.8%\uff0814\/47\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768424\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba29.2% (7\/24)\uff0cCR\u7387\u70ba20.8%\uff085\/24\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002 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ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a \u5c55\u793a\u5f62\u5f0f \u54c1\u7a2e \u6458\u8981\u6a19\u984c \u7de8\u865f\u00a0 \u53e3\u982d\u5831\u544a \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c 88 \u58c1\u5831\u5c55\u793a\u00a0 \u5229\u6c99\u6258\u514b\u62c9\u00a0 \uff08APG-2575\uff09 Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c 1641 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) \u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c 1574 Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations \u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f 3788 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) \u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da Preclinical and clinical Study of olverembatinib in patients with myeloid\/lymphoid neoplasms with FGFR1 rearrangement \u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\/\u6dcb\u5df4\u816b\u7624 1979 Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report \u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a 1999 The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial \u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76 3779 Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81 5561 APG-5918 Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM) \u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9 1528 \u5728\u7dda\u767c\u5e03 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Single CAR-t infusion during front-line consolidation induces deep and sustained remissionin newly diagnosed adult ph+b- ALL: A prospective phase 2 study \u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002 442 \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 BCL-2 inhibition in North American adult T-cell leukemia\/lymphoma: Preclinical insightsand early clinical outcomes BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c 3304 \u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09 \u53e3\u982d\u5831\u544a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a88\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388\u5831\u544a\u4eba\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388 \u6838\u5fc3\u8981\u9ede\uff1a 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CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002 \u58c1\u5831\u5c55\u793a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a1641\u5206\u6703\u5834\uff1a616. 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ASH 2025\u4e9e\u76db\u91ab\u85e5\u7522\u54c1\u76f8\u95dc\u7814\u7a76\u4e00\u89bd\uff1a \u5c55\u793a\u5f62\u5f0f \u54c1\u7a2e \u6458\u8981\u6a19\u984c \u7de8\u865f\u00a0 \u53e3\u982d\u5831\u544a \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c 88 \u58c1\u5831\u5c55\u793a\u00a0 \u5229\u6c99\u6258\u514b\u62c9\u00a0 \uff08APG-2575\uff09 Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c 1641 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Results of POLARIS-1, a global phase 3 study (Part A): olverembatinib combined with low-intensity chemotherapy in patients with newly diagnosed (ND) Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) \u4e00\u9805\u95dc\u65bc\u5967\u96f7\u5df4\u66ff\u5c3c\u806f\u5408\u4f4e\u5f37\u5ea6\u5316\u7642\u6cbb\u7642\u521d\u6cbb\uff08ND\uff09\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\uff08Ph+\uff09\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u60a3\u8005\u7684\u5168\u7403III\u671f\u7814\u7a76POLARIS-1\uff08\u7b2c\u4e00\u968e\u6bb5\uff09\u7d50\u679c 1574 Olverembatinib (HQP1351) demonstrates efficacy vs. best available therapy (BAT) in patients (pts) with tyrosine kinase inhibitor (TKI)-resistant chronic-phase chronic myeloid leukemia (CML-CP) in a registrational randomized phase 2 trial: up to 4-year follow-up including patients without T315I mutations \u5728\u4e00\u9805\u96a8\u6a5f\u3001\u6ce8\u518a\u60272\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u5967\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u5c0d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08TKI\uff09\u8010\u85e5\u7684\u6162\u6027\u671f\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08CML-CP\uff09\uff0c\u5305\u62ec\u7121T315I\u7a81\u8b8a\u60a3\u8005\u7684\u6cbb\u7642\u7642\u6548\u512a\u65bc\u73fe\u6709\u6700\u4f73\u6cbb\u7642\u65b9\u6848\uff08BAT\uff09\uff1a4\u5e74\u96a8\u8a2a\u671f 3788 Updated efficacy and safety of olverembatinib (HQP1351) as second-line therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) \u66f4\u65b0\u5967\u96f7\u5df4\u66ff\u5c3c\u4e8c\u7dda\u6cbb\u7642\u975eT315I\u7a81\u8b8aCP-CML\u60a3\u8005\u6578\u64da Preclinical and clinical Study of olverembatinib in patients with myeloid\/lymphoid neoplasms with FGFR1 rearrangement \u5967\u96f7\u5df4\u66ff\u5c3c\u7684\u81e8\u5e8a\u524d\u8207\u81e8\u5e8a\u7814\u7a76\uff1a\u6cbb\u7642\u4f34FGFR1\u91cd\u6392\u7684\u9ad3\u7cfb\/\u6dcb\u5df4\u816b\u7624 1979 Olverembatinib-mediated deep remission improves allogeneic stem cell transplantation outcome in patients with blast crisis chronic myeloid leukemia: First real-world practice report \u5967\u96f7\u5df4\u66ff\u5c3c\u4ecb\u5c0e\u7684\u6df1\u5ea6\u7de9\u89e3\u63d0\u5347\u7570\u57fa\u56e0\u5e72\u7d30\u80de\u79fb\u690d\u5728\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u6025\u8b8a\u671f\u60a3\u8005\u4e2d\u7684\u7642\u6548\uff1a\u9996\u4efd\u771f\u5be6\u4e16\u754c\u5be6\u8e10\u5831\u544a 1999 The efficacy and safety of switching to olverembatinib or continuing original TKI therapy in CML-CP patients treated with at least two prior TKIs: A prospective, multicenter, control trial \u5c0d\u65bc\u65e2\u5f80\u63a5\u53d7\u904e\u81f3\u5c11\u5169\u7a2eTKI\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6162\u6027\u671f\u60a3\u8005\uff0c\u63db\u7528\u5967\u96f7\u5df4\u66ff\u5c3c\u8207\u7e7c\u7e8c\u539fTKI\u6cbb\u7642\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\uff1a\u4e00\u9805\u524d\u77bb\u6027\u3001\u591a\u4e2d\u5fc3\u3001\u5c0d\u7167\u7814\u7a76 3779 Clinical and molecular features associated with glucolipid metabolic disorders and cardio-\/cerebro-vascular adverse events in CML patients receiving olverembatinib therapy \u5967\u96f7\u5df4\u66ff\u5c3c\u6cbb\u7642\u6162\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u60a3\u8005\u51fa\u73fe\u7cd6\u8102\u4ee3\u8b1d\u7d0a\u4e82\u53ca\u5fc3\/\u8166\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\u7684\u81e8\u5e8a\u8207\u5206\u5b50\u7279\u5f81 5561 APG-5918 Embryonic ectoderm development (EED) inhibitor APG-5918 overcomes immunomodulatory drug (IMiD) resistance as monotherapy and synergizes with IMiDs\/cereblon E3 ligase modulators (CELMoDs) in preclinical models of multiple myeloma (MM) \u80da\u80ce\u5916\u80da\u5c64\u767c\u80b2\uff08EED\uff09\u6291\u5236\u5291APG-5918\u55ae\u85e5\u5728\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u514b\u670d\u4e86\u514d\u75ab\u8abf\u7bc0\u85e5\u7269\uff08IMiD\uff09\u8010\u85e5\u6027\u4e26\u986f\u793a\u4e86\u8207IMiDs\/Cereblon E3\u9023\u63a5\u9176\u8abf\u7bc0\u5291\uff08CELMoDs\uff09\u7684\u5354\u540c\u6548\u61c9 1528 \u5728\u7dda\u767c\u5e03 \u5967\u96f7\u5df4\u66ff\u5c3c \uff08HQP1351\uff09 Single CAR-t infusion during front-line consolidation induces deep and sustained remissionin newly diagnosed adult ph+b- ALL: A prospective phase 2 study \u5c0d\u65bc\u65b0\u8a3a\u65b7\u7684\u6210\u4ebaPh\u967d\u6027B-ALL\u60a3\u8005\uff0c\u5728\u4e00\u7dda\u978f\u56fa\u6cbb\u7642\u968e\u6bb5\u9032\u884c\u55ae\u6b21CAR-T\u7d30\u80de\u8f38\u6ce8\uff0c\u53ef\u8a98\u5c0e\u6df1\u5ea6\u4e14\u6301\u4e45\u7684\u7de9\u89e3\uff1a\u4e00\u9805\u524d\u77bb\u6027II\u671f\u7814\u7a76\u3002 442 \u5229\u6c99\u6258\u514b\u62c9 \uff08APG-2575\uff09 BCL-2 inhibition in North American adult T-cell leukemia\/lymphoma: Preclinical insightsand early clinical outcomes BCL-2\u6291\u5236\u5291\u5728\u5317\u7f8e\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5\/\u6dcb\u5df4\u7624\u4e2d\u7684\u9776\u5411\u6cbb\u7642\uff1a\u81e8\u5e8a\u524d\u7814\u7a76\u8207\u65e9\u671f\u81e8\u5e8a\u7d50\u679c 3304 \u5229\u6c99\u6258\u514b\u62c9\u5165\u90782025 ASH\u5e74\u6703\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u5967\u96f7\u5df4\u66ff\u5c3c\u5165\u9078ASH\u5e74\u6703\u7684\u6458\u8981\u8a73\u7d30\u4fe1\u606f\u53c3\u898b\u540c\u671f\u767c\u5e03\u7684\u53e6\u4e00\u7bc7\u65b0\u805e\u7a3f\uff09 \u53e3\u982d\u5831\u544a Results of a registrational phase 2 study of lisaftoclax monotherapy for treatment of patients (pts) with relapsed\/refractory chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) who had failed Bruton's tyrosine kinase inhibitors (BTKis) \u4e00\u9805\u95dc\u65bc\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u6cbb\u7642\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u6cbb\u7642\u5931\u6557\u7684\u5fa9\u767c\/\u96e3\u6cbb\u6027\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u6ce8\u518a\u6027II\u671f\u7814\u7a76\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a88\u5206\u6703\u5834\uff1a642. \u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff1a\u81e8\u5e8a\u53ca\u6d41\u884c\u75c5\u5b78\u7814\u7a76\uff1a\u5fa9\u767c\u6027CLL\u53caRichter\u8f49\u5316\u7684\u6cbb\u7642\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0a\u534810:15 \u2013 10:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u665a\u4e0a11:15 \u2013 11:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662 \u5468\u53ef\u6a39\u6559\u6388\u5831\u544a\u4eba\uff1a\u912d\u5dde\u5927\u5b78\u9644\u5c6c\u816b\u7624\u91ab\u9662\u3001\u6cb3\u5357\u7701\u816b\u7624\u91ab\u9662\u00a0\u5468\u53ef\u6a39\u6559\u6388 \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT05147467\uff09\u662f\u4e00\u9805\u91dd\u5c0d\u5fa9\u767c\/\u96e3\u6cbb\u6027CLL\/SLL\u60a3\u8005\u7684\u95dc\u9375\u6ce8\u518aII\u671f\u81e8\u5e8a\u8a66\u9a57\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u3002\u5165\u7d44\u60a3\u8005\u70baBTK\u6291\u5236\u5291\u548c\u514d\u75ab\u5316\u7642\u5747\u96e3\u6cbb\u3001\u5fa9\u767c\u3001\u6216\u4e0d\u8010\u53d7\uff1b\u6216\u4e00\u7dda\u4f7f\u7528BTK\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u4e14\u4e0d\u9069\u5408\u514d\u75ab\u5316\u7642\u7684\u60a3\u8005\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u670825\u65e5\uff0c\u572872\u4f8b\u53ef\u8a55\u4f30R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u7d93\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u8a55\u4f30\u78ba\u8a8d\u7684ORR\u70ba62.5%\u3002\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u70ba23.89\u500b\u6708\uff08\u4e2d\u4f4d\u96a8\u8a2a22.01\u500b\u6708\uff09\u3002\u5728\u9ad8\u5371\u60a3\u8005\u7fa4\u9ad4\uff08\u651c\u5e36\u5982del(17p)\/TP53\u7a81\u8b8a\u3001\u5fa9\u96dc\u6838\u578b\u3001IGHV\u672a\u7a81\u8b8a\u7b49\u4e0d\u826f\u9810\u5f8c\u56e0\u7d20\uff09\u4e2d\uff0c\u6cbb\u7642\u986f\u793a\u51fa\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u6df1\u5ea6\u7de9\u89e3\u300221.8%\u9054\u5230\u5916\u5468\u8840\u5fae\u5c0f\u6b98\u7559\u75c5\uff08MRD\uff09\u9670\u6027\u3002\u572811\u4f8b\u53ef\u8a55\u4f30\u9aa8\u9ad3MRD\u7684\u60a3\u8005\u4e2d\uff0c\u67096\u4f8b\u9054\u5230MRD\u9670\u6027\u3002 \u5b89\u5168\u6027\u6578\u64da\uff1a\u5229\u6c99\u6258\u514b\u62c9\u5728BTKi\u7d93\u6cbb\u7684\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002\u6700\u5e38\u898b\u7684\u22653\u7d1a\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u8840\u6db2\u5b78\u6bd2\u6027\uff0c\u5305\u62ec\u4e2d\u6027\u7c92\u7d30\u80de\u6e1b\u5c11\u3001\u8840\u5c0f\u677f\u6e1b\u5c11\u548c\u8ca7\u8840\u7b49\u3002\u672a\u89c0\u5bdf\u5230\u4efb\u4f55\u816b\u7624\u6eb6\u89e3\u7d9c\u5408\u5f81\uff08TLS\uff09\u75c5\u4f8b\uff0c\u4e14\u7121\u85e5\u7269\u76f8\u95dc\u6b7b\u4ea1\u4e8b\u4ef6\u767c\u751f\u3002 \u7d50\u8ad6\uff1a\u5229\u6c99\u6258\u514b\u62c9\u55ae\u85e5\u7642\u6cd5\u5728\u5c0dBTK\u6291\u5236\u5291\u8010\u85e5\u7684\u3001\u91cd\u5ea6\u7d93\u6cbb\u7684R\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u5c55\u73fe\u51fa\u986f\u8457\u4e14\u6301\u4e45\u7684\u81e8\u5e8a\u7642\u6548\u4ee5\u53ca\u53ef\u63a7\u7684\u5b89\u5168\u6027\uff0c\u8868\u660e\u5176\u662f\u4e00\u7a2e\u6975\u5177\u6f5b\u529b\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002 \u58c1\u5831\u5c55\u793a Results of the APG2575AU101 study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax\u2013exposed myeloid malignancies \u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u6cbb\u7642\u521d\u6cbb\u6216\u65e2\u5f80\u4f7f\u7528\u904e\u7dad\u5948\u6258\u514b\u7684\u9ad3\u7cfb\u816b\u7624\u7684\u81e8\u5e8a\u7814\u7a76\uff08APG2575AU101\uff09\u7d50\u679c \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a\u6458\u8981\u7de8\u865f\uff1a1641\u5206\u6703\u5834\uff1a616. \u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff1a\u5728\u7814\u85e5\u7269\u53ca\u7d30\u80de\u7642\u6cd5\uff1a\u58c1\u5831\u5c55\u793aI\u5831\u544a\u6642\u9593\uff1a2025\u5e7412\u67086\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u534817:30 \u2013 19:30\uff08\u7f8e\u570b\u6771\u90e8\u6642\u9593\uff092025\u5e7412\u67087\u65e5\uff0c\u661f\u671f\u65e5\uff1b\u4e0a\u53486:30 \u2013 8:30\uff08\u5317\u4eac\u6642\u9593\uff09\u7b2c\u4e00\u4f5c\u8005\uff1aMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb\u5831\u544a\u4eba\uff1a\u00a0MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09Tapan Kadia\u535a\u58eb \u6838\u5fc3\u8981\u9ede\uff1a \u8a72\u7814\u7a76\uff08NCT04964518\uff09\u662f\u4e00\u9805I\/II\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u5229\u6c99\u6258\u514b\u62c9\u806f\u5408\u963f\u624e\u80de\u7518\u5728\u521d\u6cbb\u6216\u5fa9\u767c\/\u96e3\u6cbb\u7684\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u3001\u6df7\u5408\u8868\u578b\u6025\u6027\u767d\u8840\u75c5\uff08MPAL\uff09\u3001\u6162\u6027\u7c92\u55ae\u6838\u7d30\u80de\u767d\u8840\u75c5\uff08CMML\uff09\u6216\u4e2d\u9ad8\u5371\uff08HR\uff09\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u5291\u91cf\u548c\u81e8\u5e8a\u7642\u6548\u3002\u7814\u7a76\u7b2c1\u90e8\u5206\u70ba\u5291\u91cf\u905e\u589e\u968e\u6bb5\uff0c\u7814\u7a76\u7b2c2\u90e8\u5206\u70ba\u5291\u91cf\u62d3\u5c55\u968e\u6bb5\u3002 \u622a\u81f32025\u5e747\u67081\u65e5\uff0c\u5171\u5165\u7d44\u4e86103\u4f8b\u53d7\u8a66\u8005\uff0cAML\/MPAL\u53d7\u8a66\u800563\u4f8b\uff08\u5176\u4e2d56\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\uff0cHR MDS\/CMML\u53d7\u8a66\u800540\u4f8b\uff08\u5176\u4e2d25\u4f8b\u70ba\u5fa9\u767c\/\u96e3\u6cbb\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a\u622a\u81f32025\u5e747\u67081\u65e5\uff0c 47\u4f8b\u53ef\u8a55\u4f30\u7684\u5fa9\u767c\/\u96e3\u6cbb\u7684AML\/MPAL\u60a3\u8005\u7e3d\u6709\u6548\u7387\uff08ORR\uff09\u70ba40.4%\uff0c\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\u7387\u70ba29.8%\uff0814\/47\uff09\u3002\u5728\u53ef\u8a55\u4f30\u768424\u4f8b\u65e2\u5f80\u63a5\u53d7\u904e\u7dad\u5948\u514b\u62c9\u6cbb\u7642\u7684R\/R AML\/MPAL\u60a3\u8005\u4e2d\uff0cORR\u70ba29.2% (7\/24)\uff0cCR\u7387\u70ba20.8%\uff085\/24\uff09\uff1b 15\u4f8b\u53ef\u8a55\u4f30\u7684\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684ORR\u70ba80.0%\uff0c6\u4f8b\uff0840.0%\uff09\u7372CR\uff0c6\u4f8b\uff0840.0%\uff09\u7372\u9aa8\u9ad3CR\uff08mCR\uff09\uff1b R\/R AML\/MPAL\u6216R\/R HR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba7.6\u500b\u6708\u548c11.3\u500b\u6708\uff1b \u521d\u6cbbAML\/MPAL\u6216\u521d\u6cbbHR MDS\/CMML\u60a3\u8005\u7684\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u5206\u5225\u70ba6.3\u500b\u6708\u548c\u672a\u9054\u5230\u3002 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