{"id":376833,"date":"2025-10-30T08:10:00","date_gmt":"2025-10-30T00:10:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=376833"},"modified":"2025-10-30T08:10:00","modified_gmt":"2025-10-30T00:10:00","slug":"%e6%ad%8c%e7%a6%ae%e9%81%b8%e5%ae%9a%e5%90%8c%e9%a1%9e%e6%9c%80%e4%bd%b3%e6%af%8f%e6%9c%88%e4%b8%80%e6%ac%a1%e7%9a%ae%e4%b8%8b%e6%b3%a8%e5%b0%84%e8%83%b0%e6%be%b1%e7%b4%a0%e5%8f%97%e9%ab%94%e6%bf%80","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=376833","title":{"rendered":"\u6b4c\u79ae\u9078\u5b9a\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5"},"content":{"rendered":"
\n

–\u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0c<\/i>ASC36<\/i>\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08<\/i>observed half-life<\/i>\uff09\u7d04\u70ba<\/i>15<\/i>\u5929\uff0c\u6bd4<\/i>petrelintide<\/i>\u9577<\/i>3<\/i>\u500d\uff0c\u652f\u6301\u5728\u4eba\u9ad4\u4e2d\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\u3002<\/i><\/p>\n

–\u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08<\/i>DIO<\/i>\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff0c<\/i>ASC36<\/i>\u7684\u6e1b\u91cd\u6548\u679c\u8f03<\/i>petrelintide<\/i>\u76f8\u5c0d\u63d0\u5347\u7d04<\/i>91%<\/i>\u3002<\/i><\/p>\n

–ASC36<\/i>\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027<\/i>pH<\/i>\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316<\/i>\u00a0\uff08<\/i>no fibrillation around neutral pH<\/i>\uff09\uff0c\u53ef\u8207\u5305\u62ec<\/i>GLP-1R\/GIPR<\/i>\u96d9\u9776\u9ede\u6fc0\u52d5\u5291<\/i>ASC35<\/i>\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291\u3002<\/i><\/p>\n

–\u9810\u8a08\u5c07\u65bc<\/i>2026<\/i>\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08<\/i>FDA<\/i>\uff09\u905e\u4ea4<\/i>ASC36<\/i>\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08<\/i>IND<\/i>\uff09\u3002<\/i><\/p>\n

–\u672c\u516c\u53f8\u5c07\u65bc\u4e2d\u570b\u6a19\u51c6\u6642\u9593<\/i>2025<\/i>\u5e74<\/i>10<\/i>\u6708<\/i>30<\/i>\u65e5\u4e0a\u5348<\/i>10:00<\/i>\u8209\u884c\u96fb\u8a71\u4ea4\u6d41\u6703\uff08\u666e\u901a\u8a71\uff09\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2025\u5e7410\u670830\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u5df2\u9078\u5b9a\u4e00\u6b3e\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\uff08amylin\uff09\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u4f5c\u70ba\u81e8\u5e8a\u958b\u767c\u5019\u9078\u85e5\u7269\u3002\u6b4c\u79ae\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC36\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002<\/p>\n

ASC36\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u7d93\u8a2d\u8a08\u512a\u5316\u7684ASC36\u5be6\u73fe\u4e86\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u4ee5\u8840\u85e5\u6fc3\u5ea6\u964d\u81f3Cmax<\/sub>\u768450%\u6240\u9700\u6642\u9593\u8a08\uff09\u53ca\u66f4\u9ad8\u7684\u6bcf\u6beb\u514b\u591a\u80bd\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5f9e\u800c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\uff0c\u4e14\u6ce8\u5c04\u9ad4\u7a4d\u4e0d\u8d85\u904e1\u6beb\u5347\u3002\u9019\u4e9b\u7d93\u8a2d\u8a08\u512a\u5316\u7684\u7279\u6027\u4f7f\u5176\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\uff08scalability advantages in manufacturing\uff09\u3002<\/p>\n

\u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7de9\u91cb\u76ae\u4e0b\u5132\u5eab\u578b\uff08depot\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301ASC36\u6709\u671b\u5728\u4eba\u9ad4\u4e2d\u5be6\u73fe\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\u6cbb\u7642\u80a5\u80d6\u75c7\u3002<\/p>\n

\u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC36\u548cpetrelintide\uff0cASC36\u6e1b\u91cd\u905410.01%\uff0cpetrelintide\u90545.25%\uff0cASC36<\/span>\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\u905491%\uff08\u88681\uff09\u3002\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u66f4\u512a\uff0c\u4e5f\u53ef\u80fd\u4f7fASC36\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\u3002<\/p>\n

\u88681. \u5728\u7d93\u904e7\u5929\u6cbb\u7642\u7684DIO\u5927\u9f20\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u986f\u8457\u512a\u65bcpetrelintide\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027<\/p>\n

\n\n\n\n\n\n\n\n\n\n
\n

\u7d44\u5225<\/span><\/p>\n<\/td>\n

\n

\u7d66\u85e5\u65b9\u6848<\/span><\/p>\n<\/td>\n

\n

\u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316<\/span><\/p>\n<\/td>\n

\n

\u8f03petrelintide\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u670d\u7528\u5b89\u6170\u5291\u7684<\/span><\/p>\n

\u80a5\u80d6\u5927\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291\uff0c<\/span><\/p>\n

SQ\uff0cQ2D<\/span><\/p>\n<\/td>\n

\n

1.05\u00a0%<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7d93ASC36\u6cbb\u7642\u7684<\/span><\/p>\n

\u80a5\u80d6\u5927\u9f20<\/span><\/p>\n<\/td>\n

\n

10 nmol\/kg,<\/span><\/p>\n

SQ, Q2D<\/span><\/p>\n<\/td>\n

\n

-10.01%<\/span><\/p>\n

(p<\/i> <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291)<\/span><\/p>\n<\/td>\n

\n

91%<\/span><\/p>\n

(p<\/i> <0.0001\u5c0d\u6bd4petrelintide)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7d93petrelintide\u6cbb\u7642\u7684
\u80a5\u80d6\u5927\u9f20<\/span><\/p>\n<\/td>\n

\n

10 nmol\/kg,<\/span><\/p>\n

SQ, Q2D<\/span><\/p>\n<\/td>\n

\n

-5.25%<\/span><\/p>\n

(p<\/i> <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291)<\/span><\/p>\n<\/td>\n

\n

–<\/span><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/tr>\n
\n

\u6ce8\u91cb\uff1a<\/i>DIO\u5927\u9f20\/\u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQ2D\uff1a\u6bcf\u5169\u65e5\u4e00\u6b21\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

ASC36\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027pH\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316\uff08no fibrillation around neutral pH\uff09<\/span>\uff0c\u53ef\u8207\u5305\u62ecGLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291ASC35\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291<\/span>\u3002<\/p>\n

ASC36\u5177\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u3001\u66f4\u9ad8\u7684\u76ae\u4e0b\u751f\u7269\u5229\u7528\u5ea6\u53ca\u66f4\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u9019\u4e9b\u512a\u52e2\u8868\u660e\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u3001\u6bcf\u6708\u4e00\u6b21\u7684\u80a5\u80d6\u75c7\u7642\u6cd5\u3002<\/p>\n

\u300c\u6211\u5011\u59cb\u7d42\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u8c50\u5bcc\u80a5\u80d6\u75c7\u53ca\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC36\u7684\u81e8\u5e8a\u524d\u7279\u6027\u8868\u660e\uff0c\u5176\u6709\u671b\u5be6\u73fe\u540c\u985e\u6700\u4f73\u7642\u6548\u53ca\u6bcf\u6708\u4e00\u6b21\u7684\u7d66\u85e5\u983b\u7387\uff0c\u9019\u4e9b\u7279\u9ede\u53ef\u80fd\u5e36\u4f86\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\u548c\u66f4\u7c21\u4fbf\u3001\u5c0d\u60a3\u8005\u66f4\u53cb\u597d\u7684\u5291\u91cf\u6ef4\u5b9a\uff08titration\uff09\u65b9\u6848\u3002\u300d<\/p>\n

ASC36<\/b>\u55ae\u85e5\u53ca\u806f\u5408\u7642\u6cd5\u7814\u7a76<\/b><\/p>\n

ASC36\u55ae\u85e5\u6b63\u5728\u958b\u767c\u4e2d\uff0c\u4f5c\u70ba\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u5fc3\u9ad2\u4ee3\u8b1d\u75be\u75c5\u7684\u57fa\u77f3\u7642\u6cd5\uff08cornerstone therapy\uff09\uff0c\u540c\u6642\uff0c<\/span>\u57fa\u65bcASC36\u7684\u806f\u5408\u7642\u6cd5\u4e5f\u6b63\u5728\u958b\u767c\u4e2d\u3002\u6b4c\u79ae\u8a08\u5283\u5c07ASC36\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u548c\u6bcf\u6708\u76ae\u4e0b\u7d66\u85e5\u4e00\u6b21\u7684ASC35\uff08GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\uff09\u806f\u7528\uff0c\u6cbb\u7642\u80a5\u80d6\u75c7\u3002<\/p>\n

\u6b4c\u79ae\u7684AISBDD\u8207ULAP\u6280\u8853\u53ef\u8a2d\u8a08\u3001\u512a\u5316\u4e26\u958b\u767c\u591a\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u8d85\u9577\u6548\u591a\u80bd\uff0c\u5305\u62ecASC35\u548cASC36\u3002\u57fa\u65bc\u591a\u80bd\u7684\u7279\u6027\uff0c\u672c\u516c\u53f8\u53ef\u5229\u7528\u5176\u5c08\u6709\u7684ULAP\u6280\u8853\uff0c\u70ba\u76ae\u4e0b\u5132\u5eab\u4e2d\u7684\u591a\u80bd\u8a2d\u8a08\u591a\u7a2e\u7de9\u91cb\u901f\u7387\u5e38\u6578\uff08k<\/i>\uff09\uff0c\u5f9e\u800c\u5728\u9810\u8a2d\u7684\u7d66\u85e5\u9593\u9694\u5167\u7cbe\u78ba\u91cb\u653e\u6ce8\u5c04\u7684\u591a\u80bd\uff0c\u964d\u4f4e\u8840\u85e5\u6fc3\u5ea6\u5cf0\u8c37\u6bd4\u4e26\u6539\u5584\u81e8\u5e8a\u7642\u6548\u3002<\/p>\n

\u96fb\u8a71\u4ea4\u6d41\u6703<\/b><\/p>\n

\u6b4c\u79ae\u5c07\u65bc\u4e2d\u570b\u6a19\u51c6\u6642\u95932025\u5e7410\u670830\u65e5\u4e0a\u534810:00\u8209\u884c\u96fb\u8a71\u4ea4\u6d41\u6703\uff08\u666e\u901a\u8a71\uff09\u3002\u53ef\u901a\u904eZoom\u6703\u8b70\u865f\uff1a<\/span>978\u00a03932\u00a09387\uff0c\u6216\u5982\u4e0b\u7684\u93c8\u63a5\u53c3\u8207\u76f4\u64ad\uff1a\u00a0https:\/\/zoom.us\/j\/97839329387<\/a>\u3002<\/p>\n

\u95dc<\/b>\u65bc\u6b4c<\/b>\u79ae<\/b>\u5236<\/b>\u85e5<\/b>\u6709\u9650\u516c\u53f8<\/b><\/p>\n

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\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

Peter Vozzo<\/span>
ICR Healthcare
443-231-0505(\u7f8e\u570b)
Peter.vozzo@icrhealthcare.com<\/a><\/p>\n

\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a
+86-181-0650-9129(\u4e2d\u570b)
pr@ascletis.com<\/a>
ir@ascletis.com<\/a>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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ASC36\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u7d93\u8a2d\u8a08\u512a\u5316\u7684ASC36\u5be6\u73fe\u4e86\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u4ee5\u8840\u85e5\u6fc3\u5ea6\u964d\u81f3Cmax\u768450%\u6240\u9700\u6642\u9593\u8a08\uff09\u53ca\u66f4\u9ad8\u7684\u6bcf\u6beb\u514b\u591a\u80bd\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5f9e\u800c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\uff0c\u4e14\u6ce8\u5c04\u9ad4\u7a4d\u4e0d\u8d85\u904e1\u6beb\u5347\u3002\u9019\u4e9b\u7d93\u8a2d\u8a08\u512a\u5316\u7684\u7279\u6027\u4f7f\u5176\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\uff08scalability 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ASC36\u55ae\u85e5\u6b63\u5728\u958b\u767c\u4e2d\uff0c\u4f5c\u70ba\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u5fc3\u9ad2\u4ee3\u8b1d\u75be\u75c5\u7684\u57fa\u77f3\u7642\u6cd5\uff08cornerstone therapy\uff09\uff0c\u540c\u6642\uff0c\u57fa\u65bcASC36\u7684\u806f\u5408\u7642\u6cd5\u4e5f\u6b63\u5728\u958b\u767c\u4e2d\u3002\u6b4c\u79ae\u8a08\u5283\u5c07ASC36\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u548c\u6bcf\u6708\u76ae\u4e0b\u7d66\u85e5\u4e00\u6b21\u7684ASC35\uff08GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\uff09\u806f\u7528\uff0c\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u6b4c\u79ae\u7684AISBDD\u8207ULAP\u6280\u8853\u53ef\u8a2d\u8a08\u3001\u512a\u5316\u4e26\u958b\u767c\u591a\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u8d85\u9577\u6548\u591a\u80bd\uff0c\u5305\u62ecASC35\u548cASC36\u3002\u57fa\u65bc\u591a\u80bd\u7684\u7279\u6027\uff0c\u672c\u516c\u53f8\u53ef\u5229\u7528\u5176\u5c08\u6709\u7684ULAP\u6280\u8853\uff0c\u70ba\u76ae\u4e0b\u5132\u5eab\u4e2d\u7684\u591a\u80bd\u8a2d\u8a08\u591a\u7a2e\u7de9\u91cb\u901f\u7387\u5e38\u6578\uff08k\uff09\uff0c\u5f9e\u800c\u5728\u9810\u8a2d\u7684\u7d66\u85e5\u9593\u9694\u5167\u7cbe\u78ba\u91cb\u653e\u6ce8\u5c04\u7684\u591a\u80bd\uff0c\u964d\u4f4e\u8840\u85e5\u6fc3\u5ea6\u5cf0\u8c37\u6bd4\u4e26\u6539\u5584\u81e8\u5e8a\u7642\u6548\u3002 \u96fb\u8a71\u4ea4\u6d41\u6703 \u6b4c\u79ae\u5c07\u65bc\u4e2d\u570b\u6a19\u51c6\u6642\u95932025\u5e7410\u670830\u65e5\u4e0a\u534810:00\u8209\u884c\u96fb\u8a71\u4ea4\u6d41\u6703\uff08\u666e\u901a\u8a71\uff09\u3002\u53ef\u901a\u904eZoom\u6703\u8b70\u865f\uff1a978\u00a03932\u00a09387\uff0c\u6216\u5982\u4e0b\u7684\u93c8\u63a5\u53c3\u8207\u76f4\u64ad\uff1a\u00a0https:\/\/zoom.us\/j\/97839329387\u3002 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76ee\uff1aASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505(\u7f8e\u570b)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129(\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=376833\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u9078\u5b9a\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"-\u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301\u5728\u4eba\u9ad4\u4e2d\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\u3002 -\u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u8f03petrelintide\u76f8\u5c0d\u63d0\u5347\u7d0491%\u3002 -ASC36\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027pH\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316\u00a0\uff08no fibrillation around neutral pH\uff09\uff0c\u53ef\u8207\u5305\u62ecGLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291ASC35\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291\u3002 -\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC36\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002 -\u672c\u516c\u53f8\u5c07\u65bc\u4e2d\u570b\u6a19\u51c6\u6642\u95932025\u5e7410\u670830\u65e5\u4e0a\u534810:00\u8209\u884c\u96fb\u8a71\u4ea4\u6d41\u6703\uff08\u666e\u901a\u8a71\uff09\u3002 \u9999\u6e2f2025\u5e7410\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u5df2\u9078\u5b9a\u4e00\u6b3e\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\uff08amylin\uff09\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u4f5c\u70ba\u81e8\u5e8a\u958b\u767c\u5019\u9078\u85e5\u7269\u3002\u6b4c\u79ae\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC36\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002 ASC36\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u7d93\u8a2d\u8a08\u512a\u5316\u7684ASC36\u5be6\u73fe\u4e86\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u4ee5\u8840\u85e5\u6fc3\u5ea6\u964d\u81f3Cmax\u768450%\u6240\u9700\u6642\u9593\u8a08\uff09\u53ca\u66f4\u9ad8\u7684\u6bcf\u6beb\u514b\u591a\u80bd\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5f9e\u800c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\uff0c\u4e14\u6ce8\u5c04\u9ad4\u7a4d\u4e0d\u8d85\u904e1\u6beb\u5347\u3002\u9019\u4e9b\u7d93\u8a2d\u8a08\u512a\u5316\u7684\u7279\u6027\u4f7f\u5176\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\uff08scalability advantages in manufacturing\uff09\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7de9\u91cb\u76ae\u4e0b\u5132\u5eab\u578b\uff08depot\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301ASC36\u6709\u671b\u5728\u4eba\u9ad4\u4e2d\u5be6\u73fe\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC36\u548cpetrelintide\uff0cASC36\u6e1b\u91cd\u905410.01%\uff0cpetrelintide\u90545.25%\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\u905491%\uff08\u88681\uff09\u3002\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u66f4\u512a\uff0c\u4e5f\u53ef\u80fd\u4f7fASC36\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\u3002 \u88681. \u5728\u7d93\u904e7\u5929\u6cbb\u7642\u7684DIO\u5927\u9f20\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u986f\u8457\u512a\u65bcpetrelintide\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u7d44\u5225 \u7d66\u85e5\u65b9\u6848 \u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03petrelintide\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 \u670d\u7528\u5b89\u6170\u5291\u7684 \u80a5\u80d6\u5927\u9f20 \u5b89\u6170\u5291\uff0c SQ\uff0cQ2D 1.05\u00a0% - \u7d93ASC36\u6cbb\u7642\u7684 \u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -10.01% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) 91% (p <0.0001\u5c0d\u6bd4petrelintide) \u7d93petrelintide\u6cbb\u7642\u7684\u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -5.25% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) - \u6ce8\u91cb\uff1aDIO\u5927\u9f20\/\u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQ2D\uff1a\u6bcf\u5169\u65e5\u4e00\u6b21\u3002 ASC36\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027pH\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316\uff08no fibrillation around neutral pH\uff09\uff0c\u53ef\u8207\u5305\u62ecGLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291ASC35\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291\u3002 ASC36\u5177\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u3001\u66f4\u9ad8\u7684\u76ae\u4e0b\u751f\u7269\u5229\u7528\u5ea6\u53ca\u66f4\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u9019\u4e9b\u512a\u52e2\u8868\u660e\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u3001\u6bcf\u6708\u4e00\u6b21\u7684\u80a5\u80d6\u75c7\u7642\u6cd5\u3002 \u300c\u6211\u5011\u59cb\u7d42\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u8c50\u5bcc\u80a5\u80d6\u75c7\u53ca\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC36\u7684\u81e8\u5e8a\u524d\u7279\u6027\u8868\u660e\uff0c\u5176\u6709\u671b\u5be6\u73fe\u540c\u985e\u6700\u4f73\u7642\u6548\u53ca\u6bcf\u6708\u4e00\u6b21\u7684\u7d66\u85e5\u983b\u7387\uff0c\u9019\u4e9b\u7279\u9ede\u53ef\u80fd\u5e36\u4f86\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\u548c\u66f4\u7c21\u4fbf\u3001\u5c0d\u60a3\u8005\u66f4\u53cb\u597d\u7684\u5291\u91cf\u6ef4\u5b9a\uff08titration\uff09\u65b9\u6848\u3002\u300d ASC36\u55ae\u85e5\u53ca\u806f\u5408\u7642\u6cd5\u7814\u7a76 ASC36\u55ae\u85e5\u6b63\u5728\u958b\u767c\u4e2d\uff0c\u4f5c\u70ba\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u5fc3\u9ad2\u4ee3\u8b1d\u75be\u75c5\u7684\u57fa\u77f3\u7642\u6cd5\uff08cornerstone therapy\uff09\uff0c\u540c\u6642\uff0c\u57fa\u65bcASC36\u7684\u806f\u5408\u7642\u6cd5\u4e5f\u6b63\u5728\u958b\u767c\u4e2d\u3002\u6b4c\u79ae\u8a08\u5283\u5c07ASC36\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u548c\u6bcf\u6708\u76ae\u4e0b\u7d66\u85e5\u4e00\u6b21\u7684ASC35\uff08GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\uff09\u806f\u7528\uff0c\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 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Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76ee\uff1aASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505(\u7f8e\u570b)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129(\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=376833\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-30T00:10:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" 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Platform\uff0cULAP\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u7d93\u8a2d\u8a08\u512a\u5316\u7684ASC36\u5be6\u73fe\u4e86\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u4ee5\u8840\u85e5\u6fc3\u5ea6\u964d\u81f3Cmax\u768450%\u6240\u9700\u6642\u9593\u8a08\uff09\u53ca\u66f4\u9ad8\u7684\u6bcf\u6beb\u514b\u591a\u80bd\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5f9e\u800c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\uff0c\u4e14\u6ce8\u5c04\u9ad4\u7a4d\u4e0d\u8d85\u904e1\u6beb\u5347\u3002\u9019\u4e9b\u7d93\u8a2d\u8a08\u512a\u5316\u7684\u7279\u6027\u4f7f\u5176\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\uff08scalability advantages in manufacturing\uff09\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7de9\u91cb\u76ae\u4e0b\u5132\u5eab\u578b\uff08depot\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301ASC36\u6709\u671b\u5728\u4eba\u9ad4\u4e2d\u5be6\u73fe\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC36\u548cpetrelintide\uff0cASC36\u6e1b\u91cd\u905410.01%\uff0cpetrelintide\u90545.25%\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\u905491%\uff08\u88681\uff09\u3002\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u66f4\u512a\uff0c\u4e5f\u53ef\u80fd\u4f7fASC36\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\u3002 \u88681. \u5728\u7d93\u904e7\u5929\u6cbb\u7642\u7684DIO\u5927\u9f20\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u986f\u8457\u512a\u65bcpetrelintide\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u7d44\u5225 \u7d66\u85e5\u65b9\u6848 \u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03petrelintide\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 \u670d\u7528\u5b89\u6170\u5291\u7684 \u80a5\u80d6\u5927\u9f20 \u5b89\u6170\u5291\uff0c SQ\uff0cQ2D 1.05\u00a0% - \u7d93ASC36\u6cbb\u7642\u7684 \u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -10.01% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) 91% (p <0.0001\u5c0d\u6bd4petrelintide) \u7d93petrelintide\u6cbb\u7642\u7684\u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -5.25% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) - \u6ce8\u91cb\uff1aDIO\u5927\u9f20\/\u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQ2D\uff1a\u6bcf\u5169\u65e5\u4e00\u6b21\u3002 ASC36\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027pH\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316\uff08no fibrillation around neutral pH\uff09\uff0c\u53ef\u8207\u5305\u62ecGLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291ASC35\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291\u3002 ASC36\u5177\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u3001\u66f4\u9ad8\u7684\u76ae\u4e0b\u751f\u7269\u5229\u7528\u5ea6\u53ca\u66f4\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u9019\u4e9b\u512a\u52e2\u8868\u660e\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u3001\u6bcf\u6708\u4e00\u6b21\u7684\u80a5\u80d6\u75c7\u7642\u6cd5\u3002 \u300c\u6211\u5011\u59cb\u7d42\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u8c50\u5bcc\u80a5\u80d6\u75c7\u53ca\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC36\u7684\u81e8\u5e8a\u524d\u7279\u6027\u8868\u660e\uff0c\u5176\u6709\u671b\u5be6\u73fe\u540c\u985e\u6700\u4f73\u7642\u6548\u53ca\u6bcf\u6708\u4e00\u6b21\u7684\u7d66\u85e5\u983b\u7387\uff0c\u9019\u4e9b\u7279\u9ede\u53ef\u80fd\u5e36\u4f86\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\u548c\u66f4\u7c21\u4fbf\u3001\u5c0d\u60a3\u8005\u66f4\u53cb\u597d\u7684\u5291\u91cf\u6ef4\u5b9a\uff08titration\uff09\u65b9\u6848\u3002\u300d ASC36\u55ae\u85e5\u53ca\u806f\u5408\u7642\u6cd5\u7814\u7a76 ASC36\u55ae\u85e5\u6b63\u5728\u958b\u767c\u4e2d\uff0c\u4f5c\u70ba\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u5fc3\u9ad2\u4ee3\u8b1d\u75be\u75c5\u7684\u57fa\u77f3\u7642\u6cd5\uff08cornerstone therapy\uff09\uff0c\u540c\u6642\uff0c\u57fa\u65bcASC36\u7684\u806f\u5408\u7642\u6cd5\u4e5f\u6b63\u5728\u958b\u767c\u4e2d\u3002\u6b4c\u79ae\u8a08\u5283\u5c07ASC36\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u548c\u6bcf\u6708\u76ae\u4e0b\u7d66\u85e5\u4e00\u6b21\u7684ASC35\uff08GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\uff09\u806f\u7528\uff0c\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u6b4c\u79ae\u7684AISBDD\u8207ULAP\u6280\u8853\u53ef\u8a2d\u8a08\u3001\u512a\u5316\u4e26\u958b\u767c\u591a\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u8d85\u9577\u6548\u591a\u80bd\uff0c\u5305\u62ecASC35\u548cASC36\u3002\u57fa\u65bc\u591a\u80bd\u7684\u7279\u6027\uff0c\u672c\u516c\u53f8\u53ef\u5229\u7528\u5176\u5c08\u6709\u7684ULAP\u6280\u8853\uff0c\u70ba\u76ae\u4e0b\u5132\u5eab\u4e2d\u7684\u591a\u80bd\u8a2d\u8a08\u591a\u7a2e\u7de9\u91cb\u901f\u7387\u5e38\u6578\uff08k\uff09\uff0c\u5f9e\u800c\u5728\u9810\u8a2d\u7684\u7d66\u85e5\u9593\u9694\u5167\u7cbe\u78ba\u91cb\u653e\u6ce8\u5c04\u7684\u591a\u80bd\uff0c\u964d\u4f4e\u8840\u85e5\u6fc3\u5ea6\u5cf0\u8c37\u6bd4\u4e26\u6539\u5584\u81e8\u5e8a\u7642\u6548\u3002 \u96fb\u8a71\u4ea4\u6d41\u6703 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Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\uff0c\u6b4c\u79ae\u5df2\u81ea\u4e3b\u7814\u767c\u591a\u6b3e\u5019\u9078\u85e5\u7269\uff0c\u5305\u62ec\u5176\u6838\u5fc3\u9805\u76ee\uff1aASC30\uff0c\u4e00\u6b3e\u5728\u7814\u5c0f\u5206\u5b50GLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\uff0c\u65e2\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u4e5f\u53ef\u6bcf\u6708\u4e00\u6b21\u81f3\u6bcf\u5b63\u5ea6\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4f5c\u70ba\u6e1b\u91cd\u6cbb\u7642\u7642\u6cd5\u548c\u6e1b\u91cd\u7dad\u6301\u7642\u6cd5\uff0c\u7528\u65bc\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u6b4c\u79ae\u5df2\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e0a\u5e02\uff081672.HK\uff09\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505(\u7f8e\u570b)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129(\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=376833","og_locale":"zh_TW","og_type":"article","og_title":"\u6b4c\u79ae\u9078\u5b9a\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u9032\u5165\u81e8\u5e8a\u958b\u767c\u968e\u6bb5 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"-\u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301\u5728\u4eba\u9ad4\u4e2d\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\u3002 -\u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u8f03petrelintide\u76f8\u5c0d\u63d0\u5347\u7d0491%\u3002 -ASC36\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027pH\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316\u00a0\uff08no fibrillation around neutral pH\uff09\uff0c\u53ef\u8207\u5305\u62ecGLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291ASC35\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291\u3002 -\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC36\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002 -\u672c\u516c\u53f8\u5c07\u65bc\u4e2d\u570b\u6a19\u51c6\u6642\u95932025\u5e7410\u670830\u65e5\u4e0a\u534810:00\u8209\u884c\u96fb\u8a71\u4ea4\u6d41\u6703\uff08\u666e\u901a\u8a71\uff09\u3002 \u9999\u6e2f2025\u5e7410\u670830\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u5df2\u9078\u5b9a\u4e00\u6b3e\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\uff08amylin\uff09\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u4f5c\u70ba\u81e8\u5e8a\u958b\u767c\u5019\u9078\u85e5\u7269\u3002\u6b4c\u79ae\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC36\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002 ASC36\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u7d93\u8a2d\u8a08\u512a\u5316\u7684ASC36\u5be6\u73fe\u4e86\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u4ee5\u8840\u85e5\u6fc3\u5ea6\u964d\u81f3Cmax\u768450%\u6240\u9700\u6642\u9593\u8a08\uff09\u53ca\u66f4\u9ad8\u7684\u6bcf\u6beb\u514b\u591a\u80bd\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5f9e\u800c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\uff0c\u4e14\u6ce8\u5c04\u9ad4\u7a4d\u4e0d\u8d85\u904e1\u6beb\u5347\u3002\u9019\u4e9b\u7d93\u8a2d\u8a08\u512a\u5316\u7684\u7279\u6027\u4f7f\u5176\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\uff08scalability advantages in manufacturing\uff09\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7de9\u91cb\u76ae\u4e0b\u5132\u5eab\u578b\uff08depot\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301ASC36\u6709\u671b\u5728\u4eba\u9ad4\u4e2d\u5be6\u73fe\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC36\u548cpetrelintide\uff0cASC36\u6e1b\u91cd\u905410.01%\uff0cpetrelintide\u90545.25%\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\u905491%\uff08\u88681\uff09\u3002\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u66f4\u512a\uff0c\u4e5f\u53ef\u80fd\u4f7fASC36\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\u3002 \u88681. \u5728\u7d93\u904e7\u5929\u6cbb\u7642\u7684DIO\u5927\u9f20\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u986f\u8457\u512a\u65bcpetrelintide\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u7d44\u5225 \u7d66\u85e5\u65b9\u6848 \u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03petrelintide\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 \u670d\u7528\u5b89\u6170\u5291\u7684 \u80a5\u80d6\u5927\u9f20 \u5b89\u6170\u5291\uff0c SQ\uff0cQ2D 1.05\u00a0% - \u7d93ASC36\u6cbb\u7642\u7684 \u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -10.01% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) 91% (p <0.0001\u5c0d\u6bd4petrelintide) \u7d93petrelintide\u6cbb\u7642\u7684\u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -5.25% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) - \u6ce8\u91cb\uff1aDIO\u5927\u9f20\/\u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQ2D\uff1a\u6bcf\u5169\u65e5\u4e00\u6b21\u3002 ASC36\u5177\u6709\u512a\u8d8a\u7684\u7406\u5316\u7a69\u5b9a\u6027\uff0c\u5728\u4e2d\u6027pH\u503c\u9644\u8fd1\u4e0d\u5f62\u6210\u7e96\u7dad\u5316\uff08no fibrillation around neutral pH\uff09\uff0c\u53ef\u8207\u5305\u62ecGLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291ASC35\u5728\u5167\u7684\u5176\u4ed6\u591a\u80bd\u85e5\u7269\u958b\u767c\u5fa9\u65b9\u5236\u5291\u3002 ASC36\u5177\u6709\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\u3001\u66f4\u9ad8\u7684\u76ae\u4e0b\u751f\u7269\u5229\u7528\u5ea6\u53ca\u66f4\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u9019\u4e9b\u512a\u52e2\u8868\u660e\u5176\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u3001\u6bcf\u6708\u4e00\u6b21\u7684\u80a5\u80d6\u75c7\u7642\u6cd5\u3002 \u300c\u6211\u5011\u59cb\u7d42\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u7642\u6cd5\uff0c\u4ee5\u8c50\u5bcc\u80a5\u80d6\u75c7\u53ca\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC36\u7684\u81e8\u5e8a\u524d\u7279\u6027\u8868\u660e\uff0c\u5176\u6709\u671b\u5be6\u73fe\u540c\u985e\u6700\u4f73\u7642\u6548\u53ca\u6bcf\u6708\u4e00\u6b21\u7684\u7d66\u85e5\u983b\u7387\uff0c\u9019\u4e9b\u7279\u9ede\u53ef\u80fd\u5e36\u4f86\u512a\u8d8a\u7684\u6e1b\u91cd\u6548\u679c\u548c\u66f4\u7c21\u4fbf\u3001\u5c0d\u60a3\u8005\u66f4\u53cb\u597d\u7684\u5291\u91cf\u6ef4\u5b9a\uff08titration\uff09\u65b9\u6848\u3002\u300d ASC36\u55ae\u85e5\u53ca\u806f\u5408\u7642\u6cd5\u7814\u7a76 ASC36\u55ae\u85e5\u6b63\u5728\u958b\u767c\u4e2d\uff0c\u4f5c\u70ba\u6cbb\u7642\u5305\u62ec\u80a5\u80d6\u75c7\u5728\u5167\u7684\u5fc3\u9ad2\u4ee3\u8b1d\u75be\u75c5\u7684\u57fa\u77f3\u7642\u6cd5\uff08cornerstone therapy\uff09\uff0c\u540c\u6642\uff0c\u57fa\u65bcASC36\u7684\u806f\u5408\u7642\u6cd5\u4e5f\u6b63\u5728\u958b\u767c\u4e2d\u3002\u6b4c\u79ae\u8a08\u5283\u5c07ASC36\uff08\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\uff09\u548c\u6bcf\u6708\u76ae\u4e0b\u7d66\u85e5\u4e00\u6b21\u7684ASC35\uff08GLP-1R\/GIPR\u96d9\u9776\u9ede\u6fc0\u52d5\u5291\uff09\u806f\u7528\uff0c\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u6b4c\u79ae\u7684AISBDD\u8207ULAP\u6280\u8853\u53ef\u8a2d\u8a08\u3001\u512a\u5316\u4e26\u958b\u767c\u591a\u6b3e\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u8d85\u9577\u6548\u591a\u80bd\uff0c\u5305\u62ecASC35\u548cASC36\u3002\u57fa\u65bc\u591a\u80bd\u7684\u7279\u6027\uff0c\u672c\u516c\u53f8\u53ef\u5229\u7528\u5176\u5c08\u6709\u7684ULAP\u6280\u8853\uff0c\u70ba\u76ae\u4e0b\u5132\u5eab\u4e2d\u7684\u591a\u80bd\u8a2d\u8a08\u591a\u7a2e\u7de9\u91cb\u901f\u7387\u5e38\u6578\uff08k\uff09\uff0c\u5f9e\u800c\u5728\u9810\u8a2d\u7684\u7d66\u85e5\u9593\u9694\u5167\u7cbe\u78ba\u91cb\u653e\u6ce8\u5c04\u7684\u591a\u80bd\uff0c\u964d\u4f4e\u8840\u85e5\u6fc3\u5ea6\u5cf0\u8c37\u6bd4\u4e26\u6539\u5584\u81e8\u5e8a\u7642\u6548\u3002 \u96fb\u8a71\u4ea4\u6d41\u6703 \u6b4c\u79ae\u5c07\u65bc\u4e2d\u570b\u6a19\u51c6\u6642\u95932025\u5e7410\u670830\u65e5\u4e0a\u534810:00\u8209\u884c\u96fb\u8a71\u4ea4\u6d41\u6703\uff08\u666e\u901a\u8a71\uff09\u3002\u53ef\u901a\u904eZoom\u6703\u8b70\u865f\uff1a978\u00a03932\u00a09387\uff0c\u6216\u5982\u4e0b\u7684\u93c8\u63a5\u53c3\u8207\u76f4\u64ad\uff1a\u00a0https:\/\/zoom.us\/j\/97839329387\u3002 \u95dc\u65bc\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u5168\u50f9\u503c\u93c8\u6574\u5408\u578b\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u805a\u7126\u6709\u671b\u6210\u70ba\u6cbb\u7642\u4ee3\u8b1d\u75be\u75c5\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u548c\u540c\u985e\u9996\u5275\uff08first-in-class\uff09\u85e5\u7269\u7684\u958b\u767c\u548c\u5546\u696d\u5316\u3002\u5229\u7528\u516c\u53f8\u5c08\u6709\u7684\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug 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\u6b4c\u79ae\u5236\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u7c21\u7a31\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u5e03\uff0c\u5df2\u9078\u5b9a\u4e00\u6b3e\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u80f0\u6fb1\u7d20\uff08amylin\uff09\u53d7\u9ad4\u6fc0\u52d5\u5291ASC36\u4f5c\u70ba\u81e8\u5e8a\u958b\u767c\u5019\u9078\u85e5\u7269\u3002\u6b4c\u79ae\u9810\u8a08\u5c07\u65bc2026\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u5411\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u905e\u4ea4ASC36\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb\uff08IND\uff09\u3002 ASC36\u662f\u5229\u7528\u6b4c\u79ae\u57fa\u65bc\u7d50\u69cb\u7684AI\u8f14\u52a9\u85e5\u7269\u767c\u73fe\uff08Artificial Intelligence-Assisted Structure-Based Drug Discovery\uff0cAISBDD\uff09\u548c\u8d85\u9577\u6548\u85e5\u7269\u958b\u767c\u5e73\u53f0\uff08Ultra-Long-Acting Platform\uff0cULAP\uff09\u6280\u8853\u81ea\u4e3b\u7814\u767c\u7684\u80f0\u6fb1\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291\u591a\u80bd\u3002\u7d93\u8a2d\u8a08\u512a\u5316\u7684ASC36\u5be6\u73fe\u4e86\u66f4\u9577\u7684\u8868\u89c0\u534a\u8870\u671f\uff08\u4ee5\u8840\u85e5\u6fc3\u5ea6\u964d\u81f3Cmax\u768450%\u6240\u9700\u6642\u9593\u8a08\uff09\u53ca\u66f4\u9ad8\u7684\u6bcf\u6beb\u514b\u591a\u80bd\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5f9e\u800c\u652f\u6301\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u7d66\u85e5\uff0c\u4e14\u6ce8\u5c04\u9ad4\u7a4d\u4e0d\u8d85\u904e1\u6beb\u5347\u3002\u9019\u4e9b\u7d93\u8a2d\u8a08\u512a\u5316\u7684\u7279\u6027\u4f7f\u5176\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\uff08scalability advantages in manufacturing\uff09\u3002 \u5728\u982d\u5c0d\u982d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\u7814\u7a76\u4e2d\uff0cASC36\u7de9\u91cb\u76ae\u4e0b\u5132\u5eab\u578b\uff08depot\uff09\u5236\u5291\u7684\u5e73\u5747\u8868\u89c0\u534a\u8870\u671f\uff08observed half-life\uff09\u7d04\u70ba15\u5929\uff0c\u6bd4petrelintide\u95773\u500d\uff0c\u652f\u6301ASC36\u6709\u671b\u5728\u4eba\u9ad4\u4e2d\u5be6\u73fe\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\u6cbb\u7642\u80a5\u80d6\u75c7\u3002 \u5728\u982d\u5c0d\u982d\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5927\u9f20\u7814\u7a76\u4e2d\uff08DIO\u6a21\u578b\u5df2\u88ab\u8b49\u5be6\u5c0d\u4eba\u9ad4\u4e2d\u7684\u7642\u6548\u5177\u6709\u9ad8\u5ea6\u9810\u6e2c\u6027\uff09\uff0c\u7d66\u85e5\u76f8\u540c\u6469\u723e\u6fc3\u5ea6\u7684ASC36\u548cpetrelintide\uff0cASC36\u6e1b\u91cd\u905410.01%\uff0cpetrelintide\u90545.25%\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347\u905491%\uff08\u88681\uff09\u3002\u6bcf\u6beb\u514b\u591a\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u66f4\u512a\uff0c\u4e5f\u53ef\u80fd\u4f7fASC36\u5728\u898f\u6a21\u5316\u751f\u7522\u4e2d\u6210\u672c\u66f4\u4f4e\u3002 \u88681. \u5728\u7d93\u904e7\u5929\u6cbb\u7642\u7684DIO\u5927\u9f20\u4e2d\uff0cASC36\u7684\u6e1b\u91cd\u6548\u679c\u986f\u8457\u512a\u65bcpetrelintide\uff0c\u4e14\u5dee\u7570\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027 \u7d44\u5225 \u7d66\u85e5\u65b9\u6848 \u76f8\u5c0d\u57fa\u7dda\u7684\u7e3d\u9ad4\u91cd\u8b8a\u5316 \u8f03petrelintide\u7684\u6e1b\u91cd\u6548\u679c\u76f8\u5c0d\u63d0\u5347 \u670d\u7528\u5b89\u6170\u5291\u7684 \u80a5\u80d6\u5927\u9f20 \u5b89\u6170\u5291\uff0c SQ\uff0cQ2D 1.05\u00a0% - \u7d93ASC36\u6cbb\u7642\u7684 \u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -10.01% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) 91% (p <0.0001\u5c0d\u6bd4petrelintide) \u7d93petrelintide\u6cbb\u7642\u7684\u80a5\u80d6\u5927\u9f20 10 nmol\/kg, SQ, Q2D -5.25% (p <0.0001\u5c0d\u6bd4\u5b89\u6170\u5291) - \u6ce8\u91cb\uff1aDIO\u5927\u9f20\/\u80a5\u80d6\u5927\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u5927\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQ2D\uff1a\u6bcf\u5169\u65e5\u4e00\u6b21\u3002 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