{"id":374727,"date":"2025-10-23T14:18:00","date_gmt":"2025-10-23T06:18:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=374727"},"modified":"2025-10-23T14:18:00","modified_gmt":"2025-10-23T06:18:00","slug":"%e6%9c%80%e5%a4%a7%e9%87%8c%e7%a8%8b%e7%a2%91%e4%bb%98%e6%ac%be%e5%88%b0%e8%b3%ac-%e4%b8%80%e5%ae%b6%e4%b8%ad%e5%9c%8b%e9%86%ab%e8%97%a5mnc%e5%bc%b7%e5%8b%a2%e5%b4%9b%e8%b5%b7","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=374727","title":{"rendered":"\u6700\u5927\u91cc\u7a0b\u7891\u4ed8\u6b3e\u5230\u8cec \u4e00\u5bb6\u4e2d\u570b\u91ab\u85e5MNC\u5f37\u52e2\u5d1b\u8d77"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u5317\u4eac<\/span><span class=\"legendSpanClass\">2025\u5e7410\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; 2025\u5e7410\u6708\uff0c\u4e2d\u570b\u5275\u65b0\u85e5\u65b0\u661f\u767e\u5229\u5929\u6046\uff08<span id=\"spanHghltd318\">Biokin<\/span>\uff09\u548c\u8de8\u570b\u91ab\u85e5\u5de8\u982dBMS\u7684\u5408\u4f5c\u89f8\u767c\u4e862.5\u5104\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u689d\u4ef6\u2014\u2014\u64da\u4fe1\u662f\u6210\u767e\u4e0a\u5343\u8d77\u4e2d\u570b\u65b0\u85e5\u5c0d\u5916\u6388\u6b0a\u4e2d\uff0c\u6700\u5927\u7684\u4e00\u7b46ADC\u85e5\u7269\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5176\u6574\u9ad4\u4ea4\u6613\u6b64\u524d\u4e5f\u5275\u9020\u4e86\u4e2d\u570b\u55ae\u85e5\u8cc7\u7522\u6388\u6b0a\u7e3d\u50f9\u7d00\u9304\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"> <a href=\"https:\/\/mma.prnasia.com\/media2\/2802852\/1202900558.html\" target=\"_blank\" rel=\"nofollow\" style=\"color: #0000FF\">  <\/a> <br \/><span>iza-bren, a potential first-in-class ADC comprised of an EGFR x HER3 bispecific antibody conjugated<\/span><\/p>\n<\/p><\/div>\n<p>\u8fd1\u5e7e\u5e74\u4f86\uff0c\u6d3b\u8e8d\u7684\u4e2d\u570b\u91ab\u85e5\u7cfb\u7d71\u8fc5\u901f\u6210\u70ba\u5168\u7403\u65b0\u578b\u85e5\u7269\u5206\u5b50\u6700\u91cd\u8981\u7684\u63d0\u4f9b\u8005\u3002\u7121\u8ad6\u5728\u4e2d\u570b\u9084\u662f\u7f8e\u570b\uff0c\u9019\u985e\u5408\u4f5c\u901a\u5e38\u5b58\u5728\u4e0d\u78ba\u5b9a\u6027\uff0c\u4f7f\u5f97\u90a3\u4e9b\u540d\u4e0d\u898b\u7d93\u50b3\u7684\u6388\u6b0a\u65b9\u66f4\u6613\u906d\u53d7\u8cea\u7591\u3002\u7e7c2024\u5e74\u521d\u6536\u52308\u5104\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\u5f8c\uff0c\u767e\u5229\u5929\u6046\u8207\u8001\u7df4\u7684BMS\u4e4b\u9593\u5408\u4f5c\u518d\u6b21\u5f97\u4ee5\u9806\u5229\u63a8\u9032\uff0c\u8b93\u4e00\u4e9b\u6301\u61f7\u7591\u8ad6\u8005\u4e0d\u5f97\u4e0d\u78ba\u8a8d\u6f5b\u5728\u91cd\u78c5\u70b8\u5f48\u85e5\u7269iza-bren\u7684\u50f9\u503c\u3002<\/p>\n<p>\u63a8\u9032\u5408\u4f5c\u7684\u52d5\u529b\uff0c\u4f86\u81eaiza-bren\u7642\u6548\u88ab\u4e0d\u65b7\u9a57\u8b49\u3002\u57282025\u5e74\u79cb\u5929\u7684\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\uff0c\u7576\u4e2d\u570b\u91ab\u751f\u65b9\u6587\u5cf0\u516c\u4f48\u4e86\u5728\u4e2d\u570b\u7684\u4e00\u7d44\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u4e4b\u5f8c\u3002\u4e00\u4f4d\u4f86\u81ea\u4e45\u8ca0\u76db\u540d\u7684\u7f8e\u570b\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684\u91ab\u751f\u627e\u5230\u65b9\u8aaa\uff0c\u671f\u5f85\u9019\u6b3e\u85e5\u7269\u80fd\u5920\u65e9\u65e5\u5230\u7f8e\u570b\u4e0a\u5e02\u3002<\/p>\n<p>\u9019\u6a23\u7684\u5c0d\u8a71\u5728\u904e\u53bb\u662f\u4e0d\u53ef\u60f3\u50cf\u7684\u3002\u5118\u7ba1\u904e\u53bb\u5341\u5e7e\u5e74\u88e1\u4e2d\u570b\u7684\u751f\u7269\u88fd\u85e5\u7522\u696d\u53d6\u5f97\u5de8\u5927\u9032\u6b65\uff0c\u4f46\u662f\u5168\u4e16\u754c\u5e7e\u4e4e\u6240\u6709First-in-Class\u65b0\u85e5\u4ecd\u7136\u90fd\u4f86\u81ea\u897f\u65b9\u3002\u4e2d\u570b\u5728\u52aa\u529b\u52a0\u5feb\u5f15\u9032\u6d77\u5916\u65b0\u85e5\u7684\u540c\u6642\uff0c\u4e5f\u5728\u5927\u529b\u652f\u6301\u4e2d\u570b\u85e5\u4f01\u548c\u81e8\u5e8a\u7cfb\u7d71\u5c55\u958b\u5275\u65b0\u3002<\/p>\n<p>\u65b9\u6587\u5cf0\u4f9b\u8077\u65bc\u4e2d\u570b\u8457\u540d\u7684\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u4ed6\u5011\u5c0diza-bren\u9032\u884c\u4e86\u9577\u9054\u6578\u5e74\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u5728\u4e00\u9805\u7d93\u904e\u5176\u4ed6\u85e5\u7269\u4e00\u7dda\u6cbb\u7642\u3001\u4e14\u672a\u63a5\u53d7\u5316\u7642\u768450\u540d\u5c40\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8aNSCLC\u7684\u7814\u7a76\u4e2d\uff0ciza-bren\u63a7\u5236\u816b\u7624\u4e0d\u5fa9\u767c\u7684\u6642\u9593\u8d85\u904e\u4e00\u5e74\u2014\u2014\u6bd4\u73fe\u6709\u5168\u7403\u6700\u512a\u6cbb\u7642\u65b9\u6848\u5ef6\u9577\u4e86\u8fd1\u4e00\u500d\u3002<\/p>\n<p>10\u6708\u4e2d\u65ec\u7684\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff092025 \u5e74\u6703\uff0c\u518d\u6b21\u5e36\u4f86\u4e86iza-bren\u7684\u597d\u6d88\u606f\u3002\u9019\u6b3e\u5168\u7403\u9996\u5275 EGFR\u00d7HER3 \u96d9\u6297 ADC \u85e5\u7269\uff0c\u9996\u6b21\u5831\u544a\u4e86\u5176\u95dc\u9375\u8a3b\u518a III \u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6210\u679c\uff1a\u8a72\u85e5\u7269\u5728\u5f8c\u7dda\u9f3b\u54bd\u764c\u6cbb\u7642\u6838\u5fc3\u7642\u6548\u6307\u6a19\u4e0a\u5be6\u73fe\u4e86\u6210\u500d\u7684\u63d0\u5347\u3002\u7814\u7a76\u6210\u679c\u4e5f\u5728\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet\uff09\u767c\u8868\u5168\u6587\u3002<\/p>\n<p>\u76ee\u524d\uff0ciza-bren\u5df2\u5728\u5168\u7403\u958b\u5c55 40 \u4f59\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec10 \u9805\u4e2d\u570b III \u671f\u81e8\u5e8a\u8a3b\u518a\u7814\u7a76\u548c3\u9805\u6d77\u5916\u95dc\u9375\u8a3b\u518a\u7814\u7a76\uff0c\u4e2d\u7f8e\u5169\u570b\u90fd\u5c07\u5176\u4e2d\u4e00\u4e9b\u7814\u7a76\u8a8d\u5b9a\u70ba\u300c\u7a81\u7834\u6027\u7642\u6cd5\u300d\u4ee5\u52a0\u5feb\u85e5\u7269\u958b\u767c\u3002\u9019\u6b3e\u85e5\u7269\u6709\u671b\u57282026\u5e74\u7387\u5148\u65bc\u4e2d\u570b\u4e0a\u5e02\uff0c\u6309\u8a08\u5283\u6703\u65e9\u65bc\u7f8e\u570b\u4e09\u5e74\u3002\u9019\u5c0d\u4e2d\u570b\u5275\u65b0\u85e5\u5c07\u662f\u6a19\u8a8c\u6027\u8f49\u6298\u4e8b\u4ef6\u3002<\/p>\n<p>\u5168\u7403\u91ab\u85e5\u754c\u5c0diza-bren\u5c07\u6210\u70ba\u4e00\u500b\u91cd\u78c5\u70b8\u5f48\u85e5\u7269\u9010\u6b65\u9054\u6210\u5171\u8b58\uff0c\u8981\u59cb\u65bc2023\u5e74\u7684ASCO\u5e74\u6703\uff0c\u4f86\u81ea\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u7684\u5f35\u529b\u6559\u6388\u9996\u5ea6\u5831\u544a\u8a72\u85e5\u7269\u5728I\u671f\u7814\u7a76\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u4fe1\u865f\u3002<\/p>\n<p>\u7368\u7279\u7684\u96d9\u6297ADC\u6280\u8853\u8def\u7dda\uff0c\u548c\u540c\u6642\u9396\u5b9aEGFR\u8207HER3\u5169\u500b\u512a\u8cea\u9776\u9ede\uff0c\u8b93iza-bren\u8868\u9054\u51fa\u5f37\u5927\u7642\u6548\u548c\u5ee3\u8b5c\u6027\uff0c\u5438\u5f15\u6b63\u5728\u96c6\u9ad4\u9762\u81e8\u5c08\u5229\u61f8\u5d16\u3001\u6709\u610f\u4f48\u5c40ADC\u85e5\u7269\u9818\u57df\u7684\u8de8\u570b\u5de8\u982d\u3002BMS\u6700\u7d42\u4ee5\u6700\u9ad8\u53ef\u905484\u5104\u7f8e\u5143\u7684\u50f9\u683c\uff0c\u8207\u85e5\u7269\u5206\u5b50\u958b\u767c\u8005\u767e\u5229\u5929\u6046\u9054\u6210\u5728\u5168\u7403\u5171\u540c\u958b\u767c\u8207\u5546\u696d\u5316\u7684\u5354\u8b70\u3002<\/p>\n<p>\u5728\u4e2d\u570b\u773e\u591a\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u4e2d\uff0c\u767e\u5229\u5929\u6046\u662f\u500b\u53e6\u985e\u3002\u5b83\u5f9e\u4eff\u88fd\u85e5\u4f01\u696d\u8f49\u578b\u800c\u4f86\uff0c\u5275\u59cb\u4eba\u6731\u7fa9\u6c92\u6709\u6b50\u7f8e\u91ab\u85e5\u5b78\u4f4d\u6216\u8005\u8de8\u570b\u88fd\u85e5\u516c\u53f8\u4f9b\u8077\u7684\u7d93\u6b77\u3002\u5341\u591a\u5e74\u524d\uff0c\u7576\u4e2d\u570b\u653f\u5e9c\u525b\u958b\u59cb\u7e6a\u88fd\u5275\u65b0\u85e5\u751f\u614b\u7684\u85cd\u5716\uff0c\u4ed6\u5c31\u8fd1\u4e4e\u504f\u57f7\u5730\u6c7a\u5b9a\u8981All-in 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2025\u5e7410\u6708\uff0c\u4e2d\u570b\u5275\u65b0\u85e5\u65b0\u661f\u767e\u5229\u5929\u6046\uff08Biokin\uff09\u548c\u8de8\u570b\u91ab\u85e5\u5de8\u982dBMS\u7684\u5408\u4f5c\u89f8\u767c\u4e862.5\u5104\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u689d\u4ef6\u2014\u2014\u64da\u4fe1\u662f\u6210\u767e\u4e0a\u5343\u8d77\u4e2d\u570b\u65b0\u85e5\u5c0d\u5916\u6388\u6b0a\u4e2d\uff0c\u6700\u5927\u7684\u4e00\u7b46ADC\u85e5\u7269\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5176\u6574\u9ad4\u4ea4\u6613\u6b64\u524d\u4e5f\u5275\u9020\u4e86\u4e2d\u570b\u55ae\u85e5\u8cc7\u7522\u6388\u6b0a\u7e3d\u50f9\u7d00\u9304\u3002     iza-bren, a potential first-in-class ADC comprised of an EGFR x HER3 bispecific antibody conjugated  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\u63a8\u9032\u5408\u4f5c\u7684\u52d5\u529b\uff0c\u4f86\u81eaiza-bren\u7642\u6548\u88ab\u4e0d\u65b7\u9a57\u8b49\u3002\u57282025\u5e74\u79cb\u5929\u7684\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\uff0c\u7576\u4e2d\u570b\u91ab\u751f\u65b9\u6587\u5cf0\u516c\u4f48\u4e86\u5728\u4e2d\u570b\u7684\u4e00\u7d44\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u4e4b\u5f8c\u3002\u4e00\u4f4d\u4f86\u81ea\u4e45\u8ca0\u76db\u540d\u7684\u7f8e\u570b\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684\u91ab\u751f\u627e\u5230\u65b9\u8aaa\uff0c\u671f\u5f85\u9019\u6b3e\u85e5\u7269\u80fd\u5920\u65e9\u65e5\u5230\u7f8e\u570b\u4e0a\u5e02\u3002 \u9019\u6a23\u7684\u5c0d\u8a71\u5728\u904e\u53bb\u662f\u4e0d\u53ef\u60f3\u50cf\u7684\u3002\u5118\u7ba1\u904e\u53bb\u5341\u5e7e\u5e74\u88e1\u4e2d\u570b\u7684\u751f\u7269\u88fd\u85e5\u7522\u696d\u53d6\u5f97\u5de8\u5927\u9032\u6b65\uff0c\u4f46\u662f\u5168\u4e16\u754c\u5e7e\u4e4e\u6240\u6709First-in-Class\u65b0\u85e5\u4ecd\u7136\u90fd\u4f86\u81ea\u897f\u65b9\u3002\u4e2d\u570b\u5728\u52aa\u529b\u52a0\u5feb\u5f15\u9032\u6d77\u5916\u65b0\u85e5\u7684\u540c\u6642\uff0c\u4e5f\u5728\u5927\u529b\u652f\u6301\u4e2d\u570b\u85e5\u4f01\u548c\u81e8\u5e8a\u7cfb\u7d71\u5c55\u958b\u5275\u65b0\u3002 \u65b9\u6587\u5cf0\u4f9b\u8077\u65bc\u4e2d\u570b\u8457\u540d\u7684\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u4ed6\u5011\u5c0diza-bren\u9032\u884c\u4e86\u9577\u9054\u6578\u5e74\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u5728\u4e00\u9805\u7d93\u904e\u5176\u4ed6\u85e5\u7269\u4e00\u7dda\u6cbb\u7642\u3001\u4e14\u672a\u63a5\u53d7\u5316\u7642\u768450\u540d\u5c40\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8aNSCLC\u7684\u7814\u7a76\u4e2d\uff0ciza-bren\u63a7\u5236\u816b\u7624\u4e0d\u5fa9\u767c\u7684\u6642\u9593\u8d85\u904e\u4e00\u5e74\u2014\u2014\u6bd4\u73fe\u6709\u5168\u7403\u6700\u512a\u6cbb\u7642\u65b9\u6848\u5ef6\u9577\u4e86\u8fd1\u4e00\u500d\u3002 10\u6708\u4e2d\u65ec\u7684\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff092025 \u5e74\u6703\uff0c\u518d\u6b21\u5e36\u4f86\u4e86iza-bren\u7684\u597d\u6d88\u606f\u3002\u9019\u6b3e\u5168\u7403\u9996\u5275 EGFR\u00d7HER3 \u96d9\u6297 ADC \u85e5\u7269\uff0c\u9996\u6b21\u5831\u544a\u4e86\u5176\u95dc\u9375\u8a3b\u518a III \u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6210\u679c\uff1a\u8a72\u85e5\u7269\u5728\u5f8c\u7dda\u9f3b\u54bd\u764c\u6cbb\u7642\u6838\u5fc3\u7642\u6548\u6307\u6a19\u4e0a\u5be6\u73fe\u4e86\u6210\u500d\u7684\u63d0\u5347\u3002\u7814\u7a76\u6210\u679c\u4e5f\u5728\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet\uff09\u767c\u8868\u5168\u6587\u3002 \u76ee\u524d\uff0ciza-bren\u5df2\u5728\u5168\u7403\u958b\u5c55 40 \u4f59\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec10 \u9805\u4e2d\u570b III \u671f\u81e8\u5e8a\u8a3b\u518a\u7814\u7a76\u548c3\u9805\u6d77\u5916\u95dc\u9375\u8a3b\u518a\u7814\u7a76\uff0c\u4e2d\u7f8e\u5169\u570b\u90fd\u5c07\u5176\u4e2d\u4e00\u4e9b\u7814\u7a76\u8a8d\u5b9a\u70ba\u300c\u7a81\u7834\u6027\u7642\u6cd5\u300d\u4ee5\u52a0\u5feb\u85e5\u7269\u958b\u767c\u3002\u9019\u6b3e\u85e5\u7269\u6709\u671b\u57282026\u5e74\u7387\u5148\u65bc\u4e2d\u570b\u4e0a\u5e02\uff0c\u6309\u8a08\u5283\u6703\u65e9\u65bc\u7f8e\u570b\u4e09\u5e74\u3002\u9019\u5c0d\u4e2d\u570b\u5275\u65b0\u85e5\u5c07\u662f\u6a19\u8a8c\u6027\u8f49\u6298\u4e8b\u4ef6\u3002 \u5168\u7403\u91ab\u85e5\u754c\u5c0diza-bren\u5c07\u6210\u70ba\u4e00\u500b\u91cd\u78c5\u70b8\u5f48\u85e5\u7269\u9010\u6b65\u9054\u6210\u5171\u8b58\uff0c\u8981\u59cb\u65bc2023\u5e74\u7684ASCO\u5e74\u6703\uff0c\u4f86\u81ea\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u7684\u5f35\u529b\u6559\u6388\u9996\u5ea6\u5831\u544a\u8a72\u85e5\u7269\u5728I\u671f\u7814\u7a76\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u4fe1\u865f\u3002 \u7368\u7279\u7684\u96d9\u6297ADC\u6280\u8853\u8def\u7dda\uff0c\u548c\u540c\u6642\u9396\u5b9aEGFR\u8207HER3\u5169\u500b\u512a\u8cea\u9776\u9ede\uff0c\u8b93iza-bren\u8868\u9054\u51fa\u5f37\u5927\u7642\u6548\u548c\u5ee3\u8b5c\u6027\uff0c\u5438\u5f15\u6b63\u5728\u96c6\u9ad4\u9762\u81e8\u5c08\u5229\u61f8\u5d16\u3001\u6709\u610f\u4f48\u5c40ADC\u85e5\u7269\u9818\u57df\u7684\u8de8\u570b\u5de8\u982d\u3002BMS\u6700\u7d42\u4ee5\u6700\u9ad8\u53ef\u905484\u5104\u7f8e\u5143\u7684\u50f9\u683c\uff0c\u8207\u85e5\u7269\u5206\u5b50\u958b\u767c\u8005\u767e\u5229\u5929\u6046\u9054\u6210\u5728\u5168\u7403\u5171\u540c\u958b\u767c\u8207\u5546\u696d\u5316\u7684\u5354\u8b70\u3002 \u5728\u4e2d\u570b\u773e\u591a\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u4e2d\uff0c\u767e\u5229\u5929\u6046\u662f\u500b\u53e6\u985e\u3002\u5b83\u5f9e\u4eff\u88fd\u85e5\u4f01\u696d\u8f49\u578b\u800c\u4f86\uff0c\u5275\u59cb\u4eba\u6731\u7fa9\u6c92\u6709\u6b50\u7f8e\u91ab\u85e5\u5b78\u4f4d\u6216\u8005\u8de8\u570b\u88fd\u85e5\u516c\u53f8\u4f9b\u8077\u7684\u7d93\u6b77\u3002\u5341\u591a\u5e74\u524d\uff0c\u7576\u4e2d\u570b\u653f\u5e9c\u525b\u958b\u59cb\u7e6a\u88fd\u5275\u65b0\u85e5\u751f\u614b\u7684\u85cd\u5716\uff0c\u4ed6\u5c31\u8fd1\u4e4e\u504f\u57f7\u5730\u6c7a\u5b9a\u8981All-in \u5275\u65b0\u85e5\u30022014\u5e74\uff0c\u4ed6\u5728\u5168\u7403\u85e5\u7269\u767c\u73fe\u7684\u4f4e\u6f6e\u671f\u5230\u7f8e\u570b\u897f\u96c5\u5716\u5efa\u7acb\u4e86\u7cbe\u5e79\u7684\u79d1\u5b78\u968a\u4f0d\uff0c\u5f9e\u6b64\u958b\u555f\u4e86\u85e5\u7269\u7814\u767c\u7684\u5192\u96aa\u4e4b\u65c5\u3002\u6731\u7fa9\u5145\u5206\u501f\u52a9\u4e86\u4e2d\u7f8e\u5169\u570b\u751f\u7269\u88fd\u85e5\u9ad4\u7cfb\u7684\u512a\u8d8a\u6027\uff0c\u5728\u7f8e\u570b\uff0c\u4ed6\u5438\u6536\u4e86\u6709\u529b\u652f\u6490\u5f9e\u96f6\u5230\u4e00\u7684\u5275\u65b0\u8cc7\u6e90\uff0c\u800c\u4e2d\u570b\u9ad8\u6548\u7684\u884c\u653f\u7cfb\u7d71\u3001\u6d77\u91cf\u7684\u5de5\u7a0b\u5e2b\u8207\u8c50\u5bcc\u7684\u91ab\u60a3\u8cc7\u6e90\u80fd\u5920\u5c07\u5275\u65b0\u82d7\u982d\u5feb\u901f\u8b8a\u6210\u73fe\u5be6\u3002 \u6731\u7fa9\u5c0dBMS\u63d0\u51fa\u7684\u689d\u4ef6\u975e\u5e38\u7279\u5225\u2014\u2014\u9664\u4e86\u6602\u8cb4\u7684\u50f9\u78bc\uff0c\u9084\u6709\u6d77\u5916\u7814\u767c\u548c\u5546\u696d\u5316\u7684\u6b0a\u76ca\u3002\u4ed6\u6df1\u4fe1\u5f8c\u8005\u540c\u6a23\u662f\u8b93\u767e\u5229\u5929\u6046\u771f\u6b63\u8e8b\u8eab\u8de8\u570b\u85e5\u4f01\u4ff1\u6a02\u90e8\u7684\u5fc5\u8981\u689d\u4ef6\u3002\u9019\u7a2e\u91ce\u5fc3\u52c3\u52c3\u7684\u5408\u4f5c\u7bc4\u5f0f\u7684\u5efa\u7acb\u548c\u9032\u5c55\uff0c\u652f\u6490\u8457\u767e\u5229\u5929\u6046\u767c\u51fa\u4e86\u4e2d\u570b\u751f\u7269\u79d1\u6280\u516c\u53f8\u7684\u6700\u5f37\u97f3\uff1a\u8981\u57285\u5e74\u5167\u6210\u70ba\u4e00\u5bb6\u8de8\u570b\u516c\u53f8\uff0c\u9019\u662f\u4e2d\u570b\u91ab\u85e5\u7522\u696d\u5168\u7403\u7af6\u722d\u529b\u7684\u6700\u7d42\u9ad4\u73fe\u3002 \u9664\u4e86iza-bren\uff0c\u767e\u5229\u5929\u6046\u7684\u7b2c\u4e8c\u500b\u9032\u5165III\u671f\u81e8\u5e8a\u7814\u7a76\u7684ADC\u85e5\u7269T-bren\u5728ESMO\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u81e8\u5e8a\u7814\u7a76\u6210\u679c\uff0c\u9019\u6b3e\u9762\u5411\u80ba\u764c\u3001\u80c3\u764c\u3001\u4e73\u817a\u764c\u7b49\u591a\u7a2e\u5e38\u898b\u816b\u7624\u7684\u85e5\u7269\u5206\u5b50\u540c\u6a23\u5c55\u793a\u51fa\u6210\u70baBest-in-class\u7684\u5f37\u70c8\u4fe1\u865f\u3002\u6b64\u5916\uff0cCDE\u8fd1\u671f\u9084\u6279\u51c6\u767e\u5229\u5929\u6046\u7684\u9996\u500bARC\uff08\u6297\u9ad4\u653e\u5c04\u6027\u6838\u7d20\u5076\u806f\uff09\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 \u767e\u5229\u5929\u6046\u7684\u6545\u4e8b\u5f81\u670d\u4e86\u5916\u754c\u3002\u5728\u4e2d\u570b\u5167\u5730\u80a1\u7968\u5e02\u5834\uff0c\u5b83\u7684\u5e02\u503c\u5728\u5169\u5e74\u591a\u6642\u9593\u88e1\u4e0a\u6f32\u4e8615\u500d\uff0c\u6210\u70ba\u4e2d\u570b\u91ab\u85e5\u80a1\u9f8d\u982d\u4f01\u696d\u3002\u73fe\u5728\u9999\u6e2f\u8cc7\u672c\u5e02\u5834\u6b63\u5728\u5c0d\u5b83\u5f35\u958b\u96d9\u81c2\uff0c\u767e\u5229\u5929\u6046\u53ef\u80fd\u5728\u65c1\u89c0\u8005\u7684\u9072\u7591\u4e2d\u6210\u70ba\u5168\u7403\u751f\u7269\u88fd\u85e5\u9818\u57df\u7684\u9818\u5c0e\u8005\u3002 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=374727\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6700\u5927\u91cc\u7a0b\u7891\u4ed8\u6b3e\u5230\u8cec \u4e00\u5bb6\u4e2d\u570b\u91ab\u85e5MNC\u5f37\u52e2\u5d1b\u8d77 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u5317\u4eac2025\u5e7410\u670823\u65e5 \/\u7f8e\u901a\u793e\/ -- 2025\u5e7410\u6708\uff0c\u4e2d\u570b\u5275\u65b0\u85e5\u65b0\u661f\u767e\u5229\u5929\u6046\uff08Biokin\uff09\u548c\u8de8\u570b\u91ab\u85e5\u5de8\u982dBMS\u7684\u5408\u4f5c\u89f8\u767c\u4e862.5\u5104\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u689d\u4ef6\u2014\u2014\u64da\u4fe1\u662f\u6210\u767e\u4e0a\u5343\u8d77\u4e2d\u570b\u65b0\u85e5\u5c0d\u5916\u6388\u6b0a\u4e2d\uff0c\u6700\u5927\u7684\u4e00\u7b46ADC\u85e5\u7269\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5176\u6574\u9ad4\u4ea4\u6613\u6b64\u524d\u4e5f\u5275\u9020\u4e86\u4e2d\u570b\u55ae\u85e5\u8cc7\u7522\u6388\u6b0a\u7e3d\u50f9\u7d00\u9304\u3002     iza-bren, a potential first-in-class ADC comprised of an EGFR x HER3 bispecific antibody conjugated  \u8fd1\u5e7e\u5e74\u4f86\uff0c\u6d3b\u8e8d\u7684\u4e2d\u570b\u91ab\u85e5\u7cfb\u7d71\u8fc5\u901f\u6210\u70ba\u5168\u7403\u65b0\u578b\u85e5\u7269\u5206\u5b50\u6700\u91cd\u8981\u7684\u63d0\u4f9b\u8005\u3002\u7121\u8ad6\u5728\u4e2d\u570b\u9084\u662f\u7f8e\u570b\uff0c\u9019\u985e\u5408\u4f5c\u901a\u5e38\u5b58\u5728\u4e0d\u78ba\u5b9a\u6027\uff0c\u4f7f\u5f97\u90a3\u4e9b\u540d\u4e0d\u898b\u7d93\u50b3\u7684\u6388\u6b0a\u65b9\u66f4\u6613\u906d\u53d7\u8cea\u7591\u3002\u7e7c2024\u5e74\u521d\u6536\u52308\u5104\u7f8e\u5143\u7684\u9996\u4ed8\u6b3e\u5f8c\uff0c\u767e\u5229\u5929\u6046\u8207\u8001\u7df4\u7684BMS\u4e4b\u9593\u5408\u4f5c\u518d\u6b21\u5f97\u4ee5\u9806\u5229\u63a8\u9032\uff0c\u8b93\u4e00\u4e9b\u6301\u61f7\u7591\u8ad6\u8005\u4e0d\u5f97\u4e0d\u78ba\u8a8d\u6f5b\u5728\u91cd\u78c5\u70b8\u5f48\u85e5\u7269iza-bren\u7684\u50f9\u503c\u3002 \u63a8\u9032\u5408\u4f5c\u7684\u52d5\u529b\uff0c\u4f86\u81eaiza-bren\u7642\u6548\u88ab\u4e0d\u65b7\u9a57\u8b49\u3002\u57282025\u5e74\u79cb\u5929\u7684\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\uff0c\u7576\u4e2d\u570b\u91ab\u751f\u65b9\u6587\u5cf0\u516c\u4f48\u4e86\u5728\u4e2d\u570b\u7684\u4e00\u7d44\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u4e4b\u5f8c\u3002\u4e00\u4f4d\u4f86\u81ea\u4e45\u8ca0\u76db\u540d\u7684\u7f8e\u570b\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684\u91ab\u751f\u627e\u5230\u65b9\u8aaa\uff0c\u671f\u5f85\u9019\u6b3e\u85e5\u7269\u80fd\u5920\u65e9\u65e5\u5230\u7f8e\u570b\u4e0a\u5e02\u3002 \u9019\u6a23\u7684\u5c0d\u8a71\u5728\u904e\u53bb\u662f\u4e0d\u53ef\u60f3\u50cf\u7684\u3002\u5118\u7ba1\u904e\u53bb\u5341\u5e7e\u5e74\u88e1\u4e2d\u570b\u7684\u751f\u7269\u88fd\u85e5\u7522\u696d\u53d6\u5f97\u5de8\u5927\u9032\u6b65\uff0c\u4f46\u662f\u5168\u4e16\u754c\u5e7e\u4e4e\u6240\u6709First-in-Class\u65b0\u85e5\u4ecd\u7136\u90fd\u4f86\u81ea\u897f\u65b9\u3002\u4e2d\u570b\u5728\u52aa\u529b\u52a0\u5feb\u5f15\u9032\u6d77\u5916\u65b0\u85e5\u7684\u540c\u6642\uff0c\u4e5f\u5728\u5927\u529b\u652f\u6301\u4e2d\u570b\u85e5\u4f01\u548c\u81e8\u5e8a\u7cfb\u7d71\u5c55\u958b\u5275\u65b0\u3002 \u65b9\u6587\u5cf0\u4f9b\u8077\u65bc\u4e2d\u570b\u8457\u540d\u7684\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u4ed6\u5011\u5c0diza-bren\u9032\u884c\u4e86\u9577\u9054\u6578\u5e74\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u5728\u4e00\u9805\u7d93\u904e\u5176\u4ed6\u85e5\u7269\u4e00\u7dda\u6cbb\u7642\u3001\u4e14\u672a\u63a5\u53d7\u5316\u7642\u768450\u540d\u5c40\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8aNSCLC\u7684\u7814\u7a76\u4e2d\uff0ciza-bren\u63a7\u5236\u816b\u7624\u4e0d\u5fa9\u767c\u7684\u6642\u9593\u8d85\u904e\u4e00\u5e74\u2014\u2014\u6bd4\u73fe\u6709\u5168\u7403\u6700\u512a\u6cbb\u7642\u65b9\u6848\u5ef6\u9577\u4e86\u8fd1\u4e00\u500d\u3002 10\u6708\u4e2d\u65ec\u7684\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff092025 \u5e74\u6703\uff0c\u518d\u6b21\u5e36\u4f86\u4e86iza-bren\u7684\u597d\u6d88\u606f\u3002\u9019\u6b3e\u5168\u7403\u9996\u5275 EGFR\u00d7HER3 \u96d9\u6297 ADC \u85e5\u7269\uff0c\u9996\u6b21\u5831\u544a\u4e86\u5176\u95dc\u9375\u8a3b\u518a III \u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6210\u679c\uff1a\u8a72\u85e5\u7269\u5728\u5f8c\u7dda\u9f3b\u54bd\u764c\u6cbb\u7642\u6838\u5fc3\u7642\u6548\u6307\u6a19\u4e0a\u5be6\u73fe\u4e86\u6210\u500d\u7684\u63d0\u5347\u3002\u7814\u7a76\u6210\u679c\u4e5f\u5728\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet\uff09\u767c\u8868\u5168\u6587\u3002 \u76ee\u524d\uff0ciza-bren\u5df2\u5728\u5168\u7403\u958b\u5c55 40 \u4f59\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec10 \u9805\u4e2d\u570b III \u671f\u81e8\u5e8a\u8a3b\u518a\u7814\u7a76\u548c3\u9805\u6d77\u5916\u95dc\u9375\u8a3b\u518a\u7814\u7a76\uff0c\u4e2d\u7f8e\u5169\u570b\u90fd\u5c07\u5176\u4e2d\u4e00\u4e9b\u7814\u7a76\u8a8d\u5b9a\u70ba\u300c\u7a81\u7834\u6027\u7642\u6cd5\u300d\u4ee5\u52a0\u5feb\u85e5\u7269\u958b\u767c\u3002\u9019\u6b3e\u85e5\u7269\u6709\u671b\u57282026\u5e74\u7387\u5148\u65bc\u4e2d\u570b\u4e0a\u5e02\uff0c\u6309\u8a08\u5283\u6703\u65e9\u65bc\u7f8e\u570b\u4e09\u5e74\u3002\u9019\u5c0d\u4e2d\u570b\u5275\u65b0\u85e5\u5c07\u662f\u6a19\u8a8c\u6027\u8f49\u6298\u4e8b\u4ef6\u3002 \u5168\u7403\u91ab\u85e5\u754c\u5c0diza-bren\u5c07\u6210\u70ba\u4e00\u500b\u91cd\u78c5\u70b8\u5f48\u85e5\u7269\u9010\u6b65\u9054\u6210\u5171\u8b58\uff0c\u8981\u59cb\u65bc2023\u5e74\u7684ASCO\u5e74\u6703\uff0c\u4f86\u81ea\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u7684\u5f35\u529b\u6559\u6388\u9996\u5ea6\u5831\u544a\u8a72\u85e5\u7269\u5728I\u671f\u7814\u7a76\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u4fe1\u865f\u3002 \u7368\u7279\u7684\u96d9\u6297ADC\u6280\u8853\u8def\u7dda\uff0c\u548c\u540c\u6642\u9396\u5b9aEGFR\u8207HER3\u5169\u500b\u512a\u8cea\u9776\u9ede\uff0c\u8b93iza-bren\u8868\u9054\u51fa\u5f37\u5927\u7642\u6548\u548c\u5ee3\u8b5c\u6027\uff0c\u5438\u5f15\u6b63\u5728\u96c6\u9ad4\u9762\u81e8\u5c08\u5229\u61f8\u5d16\u3001\u6709\u610f\u4f48\u5c40ADC\u85e5\u7269\u9818\u57df\u7684\u8de8\u570b\u5de8\u982d\u3002BMS\u6700\u7d42\u4ee5\u6700\u9ad8\u53ef\u905484\u5104\u7f8e\u5143\u7684\u50f9\u683c\uff0c\u8207\u85e5\u7269\u5206\u5b50\u958b\u767c\u8005\u767e\u5229\u5929\u6046\u9054\u6210\u5728\u5168\u7403\u5171\u540c\u958b\u767c\u8207\u5546\u696d\u5316\u7684\u5354\u8b70\u3002 \u5728\u4e2d\u570b\u773e\u591a\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u4e2d\uff0c\u767e\u5229\u5929\u6046\u662f\u500b\u53e6\u985e\u3002\u5b83\u5f9e\u4eff\u88fd\u85e5\u4f01\u696d\u8f49\u578b\u800c\u4f86\uff0c\u5275\u59cb\u4eba\u6731\u7fa9\u6c92\u6709\u6b50\u7f8e\u91ab\u85e5\u5b78\u4f4d\u6216\u8005\u8de8\u570b\u88fd\u85e5\u516c\u53f8\u4f9b\u8077\u7684\u7d93\u6b77\u3002\u5341\u591a\u5e74\u524d\uff0c\u7576\u4e2d\u570b\u653f\u5e9c\u525b\u958b\u59cb\u7e6a\u88fd\u5275\u65b0\u85e5\u751f\u614b\u7684\u85cd\u5716\uff0c\u4ed6\u5c31\u8fd1\u4e4e\u504f\u57f7\u5730\u6c7a\u5b9a\u8981All-in 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\u9664\u4e86iza-bren\uff0c\u767e\u5229\u5929\u6046\u7684\u7b2c\u4e8c\u500b\u9032\u5165III\u671f\u81e8\u5e8a\u7814\u7a76\u7684ADC\u85e5\u7269T-bren\u5728ESMO\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u81e8\u5e8a\u7814\u7a76\u6210\u679c\uff0c\u9019\u6b3e\u9762\u5411\u80ba\u764c\u3001\u80c3\u764c\u3001\u4e73\u817a\u764c\u7b49\u591a\u7a2e\u5e38\u898b\u816b\u7624\u7684\u85e5\u7269\u5206\u5b50\u540c\u6a23\u5c55\u793a\u51fa\u6210\u70baBest-in-class\u7684\u5f37\u70c8\u4fe1\u865f\u3002\u6b64\u5916\uff0cCDE\u8fd1\u671f\u9084\u6279\u51c6\u767e\u5229\u5929\u6046\u7684\u9996\u500bARC\uff08\u6297\u9ad4\u653e\u5c04\u6027\u6838\u7d20\u5076\u806f\uff09\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 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\u63a8\u9032\u5408\u4f5c\u7684\u52d5\u529b\uff0c\u4f86\u81eaiza-bren\u7642\u6548\u88ab\u4e0d\u65b7\u9a57\u8b49\u3002\u57282025\u5e74\u79cb\u5929\u7684\u4e16\u754c\u80ba\u764c\u5927\u6703\u4e0a\uff0c\u7576\u4e2d\u570b\u91ab\u751f\u65b9\u6587\u5cf0\u516c\u4f48\u4e86\u5728\u4e2d\u570b\u7684\u4e00\u7d44\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u4e4b\u5f8c\u3002\u4e00\u4f4d\u4f86\u81ea\u4e45\u8ca0\u76db\u540d\u7684\u7f8e\u570b\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684\u91ab\u751f\u627e\u5230\u65b9\u8aaa\uff0c\u671f\u5f85\u9019\u6b3e\u85e5\u7269\u80fd\u5920\u65e9\u65e5\u5230\u7f8e\u570b\u4e0a\u5e02\u3002 \u9019\u6a23\u7684\u5c0d\u8a71\u5728\u904e\u53bb\u662f\u4e0d\u53ef\u60f3\u50cf\u7684\u3002\u5118\u7ba1\u904e\u53bb\u5341\u5e7e\u5e74\u88e1\u4e2d\u570b\u7684\u751f\u7269\u88fd\u85e5\u7522\u696d\u53d6\u5f97\u5de8\u5927\u9032\u6b65\uff0c\u4f46\u662f\u5168\u4e16\u754c\u5e7e\u4e4e\u6240\u6709First-in-Class\u65b0\u85e5\u4ecd\u7136\u90fd\u4f86\u81ea\u897f\u65b9\u3002\u4e2d\u570b\u5728\u52aa\u529b\u52a0\u5feb\u5f15\u9032\u6d77\u5916\u65b0\u85e5\u7684\u540c\u6642\uff0c\u4e5f\u5728\u5927\u529b\u652f\u6301\u4e2d\u570b\u85e5\u4f01\u548c\u81e8\u5e8a\u7cfb\u7d71\u5c55\u958b\u5275\u65b0\u3002 \u65b9\u6587\u5cf0\u4f9b\u8077\u65bc\u4e2d\u570b\u8457\u540d\u7684\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u4ed6\u5011\u5c0diza-bren\u9032\u884c\u4e86\u9577\u9054\u6578\u5e74\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u5728\u4e00\u9805\u7d93\u904e\u5176\u4ed6\u85e5\u7269\u4e00\u7dda\u6cbb\u7642\u3001\u4e14\u672a\u63a5\u53d7\u5316\u7642\u768450\u540d\u5c40\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8aNSCLC\u7684\u7814\u7a76\u4e2d\uff0ciza-bren\u63a7\u5236\u816b\u7624\u4e0d\u5fa9\u767c\u7684\u6642\u9593\u8d85\u904e\u4e00\u5e74\u2014\u2014\u6bd4\u73fe\u6709\u5168\u7403\u6700\u512a\u6cbb\u7642\u65b9\u6848\u5ef6\u9577\u4e86\u8fd1\u4e00\u500d\u3002 10\u6708\u4e2d\u65ec\u7684\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff092025 \u5e74\u6703\uff0c\u518d\u6b21\u5e36\u4f86\u4e86iza-bren\u7684\u597d\u6d88\u606f\u3002\u9019\u6b3e\u5168\u7403\u9996\u5275 EGFR\u00d7HER3 \u96d9\u6297 ADC \u85e5\u7269\uff0c\u9996\u6b21\u5831\u544a\u4e86\u5176\u95dc\u9375\u8a3b\u518a III \u671f\u81e8\u5e8a\u7814\u7a76\u7684\u6210\u679c\uff1a\u8a72\u85e5\u7269\u5728\u5f8c\u7dda\u9f3b\u54bd\u764c\u6cbb\u7642\u6838\u5fc3\u7642\u6548\u6307\u6a19\u4e0a\u5be6\u73fe\u4e86\u6210\u500d\u7684\u63d0\u5347\u3002\u7814\u7a76\u6210\u679c\u4e5f\u5728\u570b\u969b\u9802\u7d1a\u91ab\u5b78\u671f\u520a\u300a\u67f3\u8449\u5200\u300b\uff08The Lancet\uff09\u767c\u8868\u5168\u6587\u3002 \u76ee\u524d\uff0ciza-bren\u5df2\u5728\u5168\u7403\u958b\u5c55 40 \u4f59\u9805\u81e8\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec10 \u9805\u4e2d\u570b III \u671f\u81e8\u5e8a\u8a3b\u518a\u7814\u7a76\u548c3\u9805\u6d77\u5916\u95dc\u9375\u8a3b\u518a\u7814\u7a76\uff0c\u4e2d\u7f8e\u5169\u570b\u90fd\u5c07\u5176\u4e2d\u4e00\u4e9b\u7814\u7a76\u8a8d\u5b9a\u70ba\u300c\u7a81\u7834\u6027\u7642\u6cd5\u300d\u4ee5\u52a0\u5feb\u85e5\u7269\u958b\u767c\u3002\u9019\u6b3e\u85e5\u7269\u6709\u671b\u57282026\u5e74\u7387\u5148\u65bc\u4e2d\u570b\u4e0a\u5e02\uff0c\u6309\u8a08\u5283\u6703\u65e9\u65bc\u7f8e\u570b\u4e09\u5e74\u3002\u9019\u5c0d\u4e2d\u570b\u5275\u65b0\u85e5\u5c07\u662f\u6a19\u8a8c\u6027\u8f49\u6298\u4e8b\u4ef6\u3002 \u5168\u7403\u91ab\u85e5\u754c\u5c0diza-bren\u5c07\u6210\u70ba\u4e00\u500b\u91cd\u78c5\u70b8\u5f48\u85e5\u7269\u9010\u6b65\u9054\u6210\u5171\u8b58\uff0c\u8981\u59cb\u65bc2023\u5e74\u7684ASCO\u5e74\u6703\uff0c\u4f86\u81ea\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u7684\u5f35\u529b\u6559\u6388\u9996\u5ea6\u5831\u544a\u8a72\u85e5\u7269\u5728I\u671f\u7814\u7a76\u4e2d\u5353\u8d8a\u7684\u7642\u6548\u4fe1\u865f\u3002 \u7368\u7279\u7684\u96d9\u6297ADC\u6280\u8853\u8def\u7dda\uff0c\u548c\u540c\u6642\u9396\u5b9aEGFR\u8207HER3\u5169\u500b\u512a\u8cea\u9776\u9ede\uff0c\u8b93iza-bren\u8868\u9054\u51fa\u5f37\u5927\u7642\u6548\u548c\u5ee3\u8b5c\u6027\uff0c\u5438\u5f15\u6b63\u5728\u96c6\u9ad4\u9762\u81e8\u5c08\u5229\u61f8\u5d16\u3001\u6709\u610f\u4f48\u5c40ADC\u85e5\u7269\u9818\u57df\u7684\u8de8\u570b\u5de8\u982d\u3002BMS\u6700\u7d42\u4ee5\u6700\u9ad8\u53ef\u905484\u5104\u7f8e\u5143\u7684\u50f9\u683c\uff0c\u8207\u85e5\u7269\u5206\u5b50\u958b\u767c\u8005\u767e\u5229\u5929\u6046\u9054\u6210\u5728\u5168\u7403\u5171\u540c\u958b\u767c\u8207\u5546\u696d\u5316\u7684\u5354\u8b70\u3002 \u5728\u4e2d\u570b\u773e\u591a\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u4e2d\uff0c\u767e\u5229\u5929\u6046\u662f\u500b\u53e6\u985e\u3002\u5b83\u5f9e\u4eff\u88fd\u85e5\u4f01\u696d\u8f49\u578b\u800c\u4f86\uff0c\u5275\u59cb\u4eba\u6731\u7fa9\u6c92\u6709\u6b50\u7f8e\u91ab\u85e5\u5b78\u4f4d\u6216\u8005\u8de8\u570b\u88fd\u85e5\u516c\u53f8\u4f9b\u8077\u7684\u7d93\u6b77\u3002\u5341\u591a\u5e74\u524d\uff0c\u7576\u4e2d\u570b\u653f\u5e9c\u525b\u958b\u59cb\u7e6a\u88fd\u5275\u65b0\u85e5\u751f\u614b\u7684\u85cd\u5716\uff0c\u4ed6\u5c31\u8fd1\u4e4e\u504f\u57f7\u5730\u6c7a\u5b9a\u8981All-in \u5275\u65b0\u85e5\u30022014\u5e74\uff0c\u4ed6\u5728\u5168\u7403\u85e5\u7269\u767c\u73fe\u7684\u4f4e\u6f6e\u671f\u5230\u7f8e\u570b\u897f\u96c5\u5716\u5efa\u7acb\u4e86\u7cbe\u5e79\u7684\u79d1\u5b78\u968a\u4f0d\uff0c\u5f9e\u6b64\u958b\u555f\u4e86\u85e5\u7269\u7814\u767c\u7684\u5192\u96aa\u4e4b\u65c5\u3002\u6731\u7fa9\u5145\u5206\u501f\u52a9\u4e86\u4e2d\u7f8e\u5169\u570b\u751f\u7269\u88fd\u85e5\u9ad4\u7cfb\u7684\u512a\u8d8a\u6027\uff0c\u5728\u7f8e\u570b\uff0c\u4ed6\u5438\u6536\u4e86\u6709\u529b\u652f\u6490\u5f9e\u96f6\u5230\u4e00\u7684\u5275\u65b0\u8cc7\u6e90\uff0c\u800c\u4e2d\u570b\u9ad8\u6548\u7684\u884c\u653f\u7cfb\u7d71\u3001\u6d77\u91cf\u7684\u5de5\u7a0b\u5e2b\u8207\u8c50\u5bcc\u7684\u91ab\u60a3\u8cc7\u6e90\u80fd\u5920\u5c07\u5275\u65b0\u82d7\u982d\u5feb\u901f\u8b8a\u6210\u73fe\u5be6\u3002 \u6731\u7fa9\u5c0dBMS\u63d0\u51fa\u7684\u689d\u4ef6\u975e\u5e38\u7279\u5225\u2014\u2014\u9664\u4e86\u6602\u8cb4\u7684\u50f9\u78bc\uff0c\u9084\u6709\u6d77\u5916\u7814\u767c\u548c\u5546\u696d\u5316\u7684\u6b0a\u76ca\u3002\u4ed6\u6df1\u4fe1\u5f8c\u8005\u540c\u6a23\u662f\u8b93\u767e\u5229\u5929\u6046\u771f\u6b63\u8e8b\u8eab\u8de8\u570b\u85e5\u4f01\u4ff1\u6a02\u90e8\u7684\u5fc5\u8981\u689d\u4ef6\u3002\u9019\u7a2e\u91ce\u5fc3\u52c3\u52c3\u7684\u5408\u4f5c\u7bc4\u5f0f\u7684\u5efa\u7acb\u548c\u9032\u5c55\uff0c\u652f\u6490\u8457\u767e\u5229\u5929\u6046\u767c\u51fa\u4e86\u4e2d\u570b\u751f\u7269\u79d1\u6280\u516c\u53f8\u7684\u6700\u5f37\u97f3\uff1a\u8981\u57285\u5e74\u5167\u6210\u70ba\u4e00\u5bb6\u8de8\u570b\u516c\u53f8\uff0c\u9019\u662f\u4e2d\u570b\u91ab\u85e5\u7522\u696d\u5168\u7403\u7af6\u722d\u529b\u7684\u6700\u7d42\u9ad4\u73fe\u3002 \u9664\u4e86iza-bren\uff0c\u767e\u5229\u5929\u6046\u7684\u7b2c\u4e8c\u500b\u9032\u5165III\u671f\u81e8\u5e8a\u7814\u7a76\u7684ADC\u85e5\u7269T-bren\u5728ESMO\u5927\u6703\u4e0a\u516c\u4f48\u4e86\u81e8\u5e8a\u7814\u7a76\u6210\u679c\uff0c\u9019\u6b3e\u9762\u5411\u80ba\u764c\u3001\u80c3\u764c\u3001\u4e73\u817a\u764c\u7b49\u591a\u7a2e\u5e38\u898b\u816b\u7624\u7684\u85e5\u7269\u5206\u5b50\u540c\u6a23\u5c55\u793a\u51fa\u6210\u70baBest-in-class\u7684\u5f37\u70c8\u4fe1\u865f\u3002\u6b64\u5916\uff0cCDE\u8fd1\u671f\u9084\u6279\u51c6\u767e\u5229\u5929\u6046\u7684\u9996\u500bARC\uff08\u6297\u9ad4\u653e\u5c04\u6027\u6838\u7d20\u5076\u806f\uff09\u85e5\u7269\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002 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\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u5317\u4eac2025\u5e7410\u670823\u65e5 \/\u7f8e\u901a\u793e\/ -- 2025\u5e7410\u6708\uff0c\u4e2d\u570b\u5275\u65b0\u85e5\u65b0\u661f\u767e\u5229\u5929\u6046\uff08Biokin\uff09\u548c\u8de8\u570b\u91ab\u85e5\u5de8\u982dBMS\u7684\u5408\u4f5c\u89f8\u767c\u4e862.5\u5104\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\u689d\u4ef6\u2014\u2014\u64da\u4fe1\u662f\u6210\u767e\u4e0a\u5343\u8d77\u4e2d\u570b\u65b0\u85e5\u5c0d\u5916\u6388\u6b0a\u4e2d\uff0c\u6700\u5927\u7684\u4e00\u7b46ADC\u85e5\u7269\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5176\u6574\u9ad4\u4ea4\u6613\u6b64\u524d\u4e5f\u5275\u9020\u4e86\u4e2d\u570b\u55ae\u85e5\u8cc7\u7522\u6388\u6b0a\u7e3d\u50f9\u7d00\u9304\u3002     iza-bren, a potential first-in-class ADC comprised of an EGFR x HER3 bispecific antibody conjugated  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\u65b9\u6587\u5cf0\u4f9b\u8077\u65bc\u4e2d\u570b\u8457\u540d\u7684\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\uff0c\u4ed6\u5011\u5c0diza-bren\u9032\u884c\u4e86\u9577\u9054\u6578\u5e74\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u5728\u4e00\u9805\u7d93\u904e\u5176\u4ed6\u85e5\u7269\u4e00\u7dda\u6cbb\u7642\u3001\u4e14\u672a\u63a5\u53d7\u5316\u7642\u768450\u540d\u5c40\u665a\u671f\u6216\u8f49\u79fb\u6027EGFR\u7a81\u8b8aNSCLC\u7684\u7814\u7a76\u4e2d\uff0ciza-bren\u63a7\u5236\u816b\u7624\u4e0d\u5fa9\u767c\u7684\u6642\u9593\u8d85\u904e\u4e00\u5e74\u2014\u2014\u6bd4\u73fe\u6709\u5168\u7403\u6700\u512a\u6cbb\u7642\u65b9\u6848\u5ef6\u9577\u4e86\u8fd1\u4e00\u500d\u3002 10\u6708\u4e2d\u65ec\u7684\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff092025 \u5e74\u6703\uff0c\u518d\u6b21\u5e36\u4f86\u4e86iza-bren\u7684\u597d\u6d88\u606f\u3002\u9019\u6b3e\u5168\u7403\u9996\u5275 EGFR\u00d7HER3 \u96d9\u6297 ADC 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