{"id":374725,"date":"2025-10-23T13:47:00","date_gmt":"2025-10-23T05:47:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=374725"},"modified":"2025-10-23T13:47:00","modified_gmt":"2025-10-23T05:47:00","slug":"%e6%b8%af%e7%81%a3%e6%96%b0%e8%81%9e%e7%b6%b2%ef%bc%8f%e9%ab%98%e9%86%ab%e4%bd%99%e6%98%8e%e9%9a%86%e3%80%81%e7%8e%8b%e7%85%a7%e5%85%83%e6%94%9c%e6%89%8b%e6%8e%a8%e5%8b%95tpmi%e3%80%80%e8%ae%93","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=374725","title":{"rendered":"\u6e2f\u7063\u65b0\u805e\u7db2\uff0f\u9ad8\u91ab\u4f59\u660e\u9686\u3001\u738b\u7167\u5143\u651c\u624b\u63a8\u52d5TPMI\u3000\u8b93\u4e9e\u6d32\u4eba\u64c1\u6709\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u5730\u5716"},"content":{"rendered":"<div>\n<p>\u5716\/\u9ad8\u96c4\u91ab\u5b78\u9662<\/p>\n<p>\u6e2f\u7063\u65b0\u805e\u7db2\uff0f\u9ad8\u96c4\u5831\u5c0e<br \/>\u5728\u5168\u7403\u91ab\u5b78\u5feb\u901f\u9081\u5411\u7cbe\u6e96\u91ab\u7642\uff08Precision 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\/>\u4ed6\u5f37\u8abf\uff0c\u4e0d\u540c\u65cf\u7fa4\u5b58\u5728\u660e\u986f\u907a\u50b3\u5dee\u7570\uff0c\u56e0\u6b64\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u767c\u5c55\u5fc5\u9808\u5efa\u7acb\u5728\u8de8\u65cf\u7fa4\u8cc7\u6599\u6574\u5408\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5718\u968a\u672a\u4f86\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u6a5f\u69cb\u5408\u4f5c\uff0c\u63a8\u52d5\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u5efa\u7acb\u66f4\u5177\u666e\u9069\u6027\u7684\u6a21\u578b\u8207\u6a19\u6e96\u3002<br \/><img decoding=\"async\" src=\"https:\/\/www.par-news.com\/images\/newsimg\/small\/12060_1.jpg\" alt=\"\u65b0\u805e\u5716\u7247\"><\/p>\n<p><strong>\u5716\u8aaa : \u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002\u53f31\u70ba\u69ae\u767b\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u8cc7\u6df1\u4f5c\u8005\u4e4b\u4e00\u7684\u9ad8\u91ab\u738b\u7167\u5143\u9662\u9577\u3002<\/strong><\/p>\n<p><strong>\u56db\u5927\u570b\u969b\u8ad6\u6587\u767b\u9802\u671f\u520a\u300030\u4f4d\u9ad8\u91ab\u81e8\u5e8a\u91ab\u5e2b\u5171\u7b46\u7814\u7a76<\/strong><\/p>\n<p>\u7531\u4e2d\u7814\u9662\u4e3b\u5c0e\u7684TPMI\u7814\u7a76\u6210\u679c\u4e2d\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u53c3\u8207\u56db\u7bc7\u4e3b\u8981\u570b\u969b\u8ad6\u6587\u767c\u8868\uff0c\u5206\u5225\u70ba\uff1a<\/p>\n<p>\u300aNature\u300b\uff1a\u3008The Taiwan precision medicine initiative: a cohort for large-scale studies\u3009<\/p>\n<p>\u300aNature\u300b\uff1a\u3008Population-specific polygenic risk scores developed for the Han Chinese\u3009<\/p>\n<p>\u300aNature Communications\u300b\uff1a\u3008Clinical impact of pharmacogenetic risk variants in a large Chinese cohort\u3009<\/p>\n<p>\u300aScience\u300b\uff1a\u3008Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u3009<\/p>\n<p>\u6b64\u5916\uff0c\u9ad8\u91ab\u5171\u67097\u4f4dTPMI\u5171\u540c\u4e3b\u6301\u4eba\u540c\u6642\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u5305\u62ec\uff1a<br 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content=\"\u5716\/\u9ad8\u96c4\u91ab\u5b78\u9662\u6e2f\u7063\u65b0\u805e\u7db2\uff0f\u9ad8\u96c4\u5831\u5c0e\u5728\u5168\u7403\u91ab\u5b78\u5feb\u901f\u9081\u5411\u7cbe\u6e96\u91ab\u7642\uff08Precision Medicine\uff09\u6642\u4ee3\u4e4b\u969b\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u53ca\u5176\u91ab\u7642\u9ad4\u7cfb\u4ee5\u5be6\u8b49\u79d1\u7814\u70ba\u57fa\u790e\uff0c\u7a4d\u6975\u53c3\u8207\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\uff08Taiwan Precision Medicine Initiative\uff0cTPMI\uff09\u300d\uff0c\u6210\u679c\u8000\u773c\u3002\u81ea2019\u5e74\u6295\u5165\u81f3\u4eca\uff0c\u9ad8\u91ab\u5718\u968a\u7684\u7814\u7a76\u6210\u679c\u5df2\u591a\u6b21\u767b\u4e0a\u570b\u969b\u9802\u5c16\u5b78\u8853\u671f\u520a\u300aNature\u300b\u3001\u300aNature 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: \u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002\u53f31\u70ba\u69ae\u767b\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u8cc7\u6df1\u4f5c\u8005\u4e4b\u4e00\u7684\u9ad8\u91ab\u738b\u7167\u5143\u9662\u9577\u3002\u56db\u5927\u570b\u969b\u8ad6\u6587\u767b\u9802\u671f\u520a\u300030\u4f4d\u9ad8\u91ab\u81e8\u5e8a\u91ab\u5e2b\u5171\u7b46\u7814\u7a76\u7531\u4e2d\u7814\u9662\u4e3b\u5c0e\u7684TPMI\u7814\u7a76\u6210\u679c\u4e2d\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u53c3\u8207\u56db\u7bc7\u4e3b\u8981\u570b\u969b\u8ad6\u6587\u767c\u8868\uff0c\u5206\u5225\u70ba\uff1a\u300aNature\u300b\uff1a\u3008The Taiwan precision medicine initiative: a cohort for large-scale studies\u3009\u300aNature\u300b\uff1a\u3008Population-specific polygenic risk scores developed for the Han Chinese\u3009\u300aNature Communications\u300b\uff1a\u3008Clinical impact of pharmacogenetic risk variants in a large Chinese cohort\u3009\u300aScience\u300b\uff1a\u3008Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u3009\u6b64\u5916\uff0c\u9ad8\u91ab\u5171\u67097\u4f4dTPMI\u5171\u540c\u4e3b\u6301\u4eba\u540c\u6642\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u5305\u62ec\uff1a\u738b\u7167\u5143\uff08\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\uff09\u3001\u9418\u80b2\u5fd7\uff08\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\uff09\u3001\u5433\u6587\u6b63\uff08\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\uff09\u3001\u9ec3\u5fd7\u5bcc\uff08C\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\uff09\u3001\u5f90\u5d07\u582f\uff08\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\uff09\u3001\u9673\u5d07\u6853\uff08\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\uff09\u3001\u90ed\u662d\u5b8f\uff08\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\uff09\u3002\u7814\u7a76\u6210\u679c\u591a\u5143\u958b\u82b1\u3000\u5f9e\u5931\u667a\u75c7\u5230\u57fa\u56e0\u7528\u85e5\u5728\u81e8\u5e8a\u7814\u7a76\u4e0a\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5e36\u9818\u7684\u5718\u968a\u91dd\u5c0dAPOE\u57fa\u56e0\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u95dc\u806f\u6027\u9032\u884c\u6df1\u5165\u5206\u6790\uff0c\u7814\u7a76\u986f\u793a\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4\u57fa\u56e0\u5c0d75\u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u9ad8\u65bc\u5973\u6027\uff0c\u800c75\u6b72\u4ee5\u4e0b\u65cf\u7fa4\u5247\u76f8\u53cd\u3002\u8a72\u7814\u7a76\u6210\u679c\u5df2\u520a\u767b\u65bc\u570b\u969b\u671f\u520a\uff0c\u70ba\u4e9e\u6d32\u5931\u667a\u75c7\u7814\u7a76\u63d0\u4f9b\u65b0\u8996\u89d2\u3002\u5728\u61c9\u7528\u5c64\u9762\uff0c\u9ad8\u91abTPMI\u5718\u968a\u4e5f\u958b\u767c\u51fa\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u5224\u8b80\u57fa\u56e0\u8cc7\u6599\u3001\u63d0\u5347\u7528\u85e5\u5b89\u5168\u3002\u6b64\u5916\uff0c\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u67e5\u8a62\u500b\u4eba\u5206\u6790\u7d50\u679c\uff0c\u4e86\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u5efa\u8b70\uff0c\u4e26\u53ef\u7531\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u63d0\u4f9b\u907a\u50b3\u8207\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u5c55\u671b\uff1a\u8b93\u6bcf\u4f4d\u6c11\u773e\u4eab\u6709\u5b89\u5168\u3001\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u9ad8\u91ab\u5f37\u8abf\uff0c\u672a\u4f86\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u91ab\u7642\u3001\u57fa\u56e0\u7814\u7a76\u8207\u667a\u6167\u79d1\u6280\u61c9\u7528\uff0c\u6df1\u5316TPMI\u8cc7\u6599\u5eab\u7684\u81e8\u5e8a\u8f49\u8b6f\u50f9\u503c\uff0c\u8b93\u6bcf\u4e00\u4f4d\u53f0\u7063\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u3001\u500b\u4eba\u5316\u7684\u91ab\u7642\u7167\u8b77\u3002\u5f9e\u79d1\u7814\u6578\u64da\u5230\u81e8\u5e8a\u61c9\u7528\uff0c\u9ad8\u91ab\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u5728\u570b\u969b\u91ab\u5b78\u821e\u53f0\u4e0a\u767c\u5149\u767c\u71b1\u3002\" 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Medicine\uff09\u6642\u4ee3\u4e4b\u969b\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u53ca\u5176\u91ab\u7642\u9ad4\u7cfb\u4ee5\u5be6\u8b49\u79d1\u7814\u70ba\u57fa\u790e\uff0c\u7a4d\u6975\u53c3\u8207\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\uff08Taiwan Precision Medicine Initiative\uff0cTPMI\uff09\u300d\uff0c\u6210\u679c\u8000\u773c\u3002\u81ea2019\u5e74\u6295\u5165\u81f3\u4eca\uff0c\u9ad8\u91ab\u5718\u968a\u7684\u7814\u7a76\u6210\u679c\u5df2\u591a\u6b21\u767b\u4e0a\u570b\u969b\u9802\u5c16\u5b78\u8853\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u5c55\u73fe\u5357\u53f0\u7063\u5728\u570b\u969b\u7cbe\u6e96\u91ab\u5b78\u821e\u53f0\u4e0a\u7684\u5f37\u52c1\u5be6\u529b\uff0c\u4e5f\u5960\u5b9a\u9ad8\u91ab\u5728\u4e9e\u6d32\u7cbe\u6e96\u91ab\u7642\u7814\u7a76\u7684\u9818\u822a\u5730\u4f4d\u3002\u5716\u8aaa : 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: \u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002\u53f31\u70ba\u69ae\u767b\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u8cc7\u6df1\u4f5c\u8005\u4e4b\u4e00\u7684\u9ad8\u91ab\u738b\u7167\u5143\u9662\u9577\u3002\u56db\u5927\u570b\u969b\u8ad6\u6587\u767b\u9802\u671f\u520a\u300030\u4f4d\u9ad8\u91ab\u81e8\u5e8a\u91ab\u5e2b\u5171\u7b46\u7814\u7a76\u7531\u4e2d\u7814\u9662\u4e3b\u5c0e\u7684TPMI\u7814\u7a76\u6210\u679c\u4e2d\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u53c3\u8207\u56db\u7bc7\u4e3b\u8981\u570b\u969b\u8ad6\u6587\u767c\u8868\uff0c\u5206\u5225\u70ba\uff1a\u300aNature\u300b\uff1a\u3008The Taiwan precision medicine initiative: a cohort for large-scale studies\u3009\u300aNature\u300b\uff1a\u3008Population-specific polygenic risk scores developed for the Han Chinese\u3009\u300aNature Communications\u300b\uff1a\u3008Clinical impact of pharmacogenetic risk variants in a large Chinese cohort\u3009\u300aScience\u300b\uff1a\u3008Kidney multiome-based genetic scorecard reveals convergent coding and regulatory 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studies\u3009\u300aNature\u300b\uff1a\u3008Population-specific polygenic risk scores developed for the Han Chinese\u3009\u300aNature Communications\u300b\uff1a\u3008Clinical impact of pharmacogenetic risk variants in a large Chinese cohort\u3009\u300aScience\u300b\uff1a\u3008Kidney multiome-based genetic scorecard reveals convergent coding and regulatory 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- \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u5716\/\u9ad8\u96c4\u91ab\u5b78\u9662\u6e2f\u7063\u65b0\u805e\u7db2\uff0f\u9ad8\u96c4\u5831\u5c0e\u5728\u5168\u7403\u91ab\u5b78\u5feb\u901f\u9081\u5411\u7cbe\u6e96\u91ab\u7642\uff08Precision Medicine\uff09\u6642\u4ee3\u4e4b\u969b\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u53ca\u5176\u91ab\u7642\u9ad4\u7cfb\u4ee5\u5be6\u8b49\u79d1\u7814\u70ba\u57fa\u790e\uff0c\u7a4d\u6975\u53c3\u8207\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\uff08Taiwan Precision Medicine Initiative\uff0cTPMI\uff09\u300d\uff0c\u6210\u679c\u8000\u773c\u3002\u81ea2019\u5e74\u6295\u5165\u81f3\u4eca\uff0c\u9ad8\u91ab\u5718\u968a\u7684\u7814\u7a76\u6210\u679c\u5df2\u591a\u6b21\u767b\u4e0a\u570b\u969b\u9802\u5c16\u5b78\u8853\u671f\u520a\u300aNature\u300b\u3001\u300aNature 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studies\u3009\u300aNature\u300b\uff1a\u3008Population-specific polygenic risk scores developed for the Han Chinese\u3009\u300aNature Communications\u300b\uff1a\u3008Clinical impact of pharmacogenetic risk variants in a large Chinese cohort\u3009\u300aScience\u300b\uff1a\u3008Kidney multiome-based genetic scorecard reveals convergent coding and regulatory 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