{"id":374674,"date":"2025-10-23T18:07:20","date_gmt":"2025-10-23T10:07:20","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=374674"},"modified":"2025-10-23T18:07:20","modified_gmt":"2025-10-23T10:07:20","slug":"%e9%ab%98%e9%86%ab%e5%9c%98%e9%9a%8a%e7%a9%8d%e6%a5%b5%e5%8f%83%e8%88%87%e3%80%8c%e5%8f%b0%e7%81%a3%e7%b2%be%e6%ba%96%e9%86%ab%e7%99%82%e8%a8%88%e7%95%ab%e3%80%8d%e3%80%80%e6%88%90%e6%9e%9c%e6%a6%ae","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=374674","title":{"rendered":"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a"},"content":{"rendered":"<p>\u3010\u8a18\u8005\u8607\u8212 \/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002<\/p>\n<p>\u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002<\/p>\n<p>\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002<\/p>\n<p>\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002<\/p>\n<p>\u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002<\/p>\n<p>\u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002<\/p>\n<p>\u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002<\/p>\n<p>\u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u25bc\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d \u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a\uff0c\u7531\u5de6\u81f3\u53f3\u70ba\u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u3001\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u9867\u554f\u9673\u57a3\u5d07\u9662\u58eb\u3001\u5275\u59cb\u8a08\u756b\u4e3b\u6301\u4eba\u90ed\u6c9b\u6069\u9662\u58eb\u3001\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u5433\u6587\u6b63\u6559\u6388\u3002\uff08\u5716 \/ \u9ad8\u91ab\u5718\u968a\u63d0\u4f9b\uff09<\/p>\n","protected":false},"author":4,"featured_media":374675,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[27,1038],"tags":[],"class_list":["post-374674","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-27","category-1038"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u3010\u8a18\u8005\u8607\u8212 \/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002  \u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002  \u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002  \u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=374674\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u3010\u8a18\u8005\u8607\u8212 \/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002  \u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002  \u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002  \u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=374674\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2025-10-23T10:07:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/b6333fc108300ffcc8b8078a31c68e79.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2398\" \/>\n\t<meta property=\"og:image:height\" content=\"1748\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Press Chou\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"Press Chou\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674\"},\"author\":{\"name\":\"Press Chou\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/0d1424ad2931c0f1cf112f3b4a70a2fb\"},\"headline\":\"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a\",\"datePublished\":\"2025-10-23T10:07:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674\"},\"wordCount\":77,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/b6333fc108300ffcc8b8078a31c68e79.jpg\",\"articleSection\":[\"\u5065\u5eb7\u91ab\u5b78\",\"\u9ad8\u96c4\"],\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674\",\"name\":\"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/b6333fc108300ffcc8b8078a31c68e79.jpg\",\"datePublished\":\"2025-10-23T10:07:20+00:00\",\"description\":\"\u3010\u8a18\u8005\u8607\u8212 \\\/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002 \u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002 \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002 \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002 \u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002 \u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002 \u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002 \u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/b6333fc108300ffcc8b8078a31c68e79.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/b6333fc108300ffcc8b8078a31c68e79.jpg\",\"width\":2398,\"height\":1748},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=374674#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/0d1424ad2931c0f1cf112f3b4a70a2fb\",\"name\":\"Press Chou\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4f9dd0fcd64425dde81c6b2e687c3ea616db5a05deade1f65dfc2fdf196b2512?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4f9dd0fcd64425dde81c6b2e687c3ea616db5a05deade1f65dfc2fdf196b2512?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/4f9dd0fcd64425dde81c6b2e687c3ea616db5a05deade1f65dfc2fdf196b2512?s=96&d=blank&r=g\",\"caption\":\"Press Chou\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=4\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u3010\u8a18\u8005\u8607\u8212 \/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002  \u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002  \u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002  \u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=374674","og_locale":"zh_TW","og_type":"article","og_title":"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u3010\u8a18\u8005\u8607\u8212 \/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002  \u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002  \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002  \u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002  \u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002  \u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=374674","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2025-10-23T10:07:20+00:00","og_image":[{"width":2398,"height":1748,"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/b6333fc108300ffcc8b8078a31c68e79.jpg","type":"image\/jpeg"}],"author":"Press Chou","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"Press Chou","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=374674"},"author":{"name":"Press Chou","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/0d1424ad2931c0f1cf112f3b4a70a2fb"},"headline":"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a","datePublished":"2025-10-23T10:07:20+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=374674"},"wordCount":77,"commentCount":0,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/b6333fc108300ffcc8b8078a31c68e79.jpg","articleSection":["\u5065\u5eb7\u91ab\u5b78","\u9ad8\u96c4"],"inLanguage":"zh-TW","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/pingtungtimes.com.tw\/?p=374674#respond"]}]},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=374674","url":"https:\/\/pingtungtimes.com.tw\/?p=374674","name":"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/b6333fc108300ffcc8b8078a31c68e79.jpg","datePublished":"2025-10-23T10:07:20+00:00","description":"\u3010\u8a18\u8005\u8607\u8212 \/ \u9ad8\u96c4\u5831\u5c0e\u3011 \u7cbe\u6e96\u91ab\u7642\u662f\u5168\u7403\u91ab\u5b78\u767c\u5c55\u7684\u95dc\u9375\u8da8\u52e2\uff0c\u96a8\u8457\u53f0\u7063\u9081\u5165\u8d85\u9ad8\u9f61\u793e\u6703\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u66a8\u91ab\u7642\u9ad4\u7cfb\u81ea2019\u5e74\u8d77\u7a4d\u6975\u53c3\u8207\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u7684\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\uff08Taiwan Precision Medicine Initiative,\u7c21\u7a31TPMI\uff09\uff0c\u9577\u671f\u4ee5\u81e8\u5e8a\u5be6\u8b49\u63a8\u52d5\u57fa\u56e0\u7814\u7a76\u8f49\u8b6f\u61c9\u7528\uff0c\u7814\u7a76\u6210\u679c\u4e0d\u50c5\u5f15\u8d77\u570b\u969b\u77da\u76ee\uff0c\u66f4\u9023\u7e8c\u69ae\u767b\u570b\u969b\u9802\u5c16\u671f\u520a\u300aNature\u300b\u3001\u300aNature Communications\u300b\u8207\u300aScience\u300b\uff0c\u9707\u64bc\u5168\u7403\u91ab\u5b78\u754c\uff0c\u66f4\u5c55\u73fe\u9ad8\u91ab\u9ad4\u7cfb\u5728\u7cbe\u6e96\u91ab\u5b78\u9818\u57df\u7684\u570b\u969b\u9818\u5c0e\u5730\u4f4d\u8207\u79d1\u7814\u80fd\u91cf\u3002 \u9ad8\u91abTPMI\u5718\u968a\u81ea2019\u5e7410\u6708\u53d6\u5f97\u4eba\u9ad4\u8a66\u9a57\u5be9\u67e5\u59d4\u54e1\u6703\uff08IRB\uff09\u6838\u51c6\u5f8c\uff0c\u65bc\u540c\u5e7411\u6708\u555f\u52d5\u7b2c\u4e00\u4f4d\u53d7\u8a66\u8005\u6536\u6848\uff0c\u622a\u81f32023\u5e74\u5e95\uff0c\u7d2f\u8a08\u5df2\u62db\u52df\u8d85\u904e46,000\u4f4d\u53c3\u8207\u8005\uff0c\u6a6b\u8de8\u5167\u3001\u5916\u3001\u5a66\u3001\u5152\u7b4932\u500b\u6b21\u5c08\u79d1\uff0c\u753138\u500b\u7814\u7a76\u5718\u968a\u3001300\u4f4d\u81e8\u5e8a\u91ab\u5e2b\u8207\u7814\u7a76\u4eba\u54e1\u5171\u540c\u53c3\u8207\uff0c\u662f\u5357\u53f0\u7063\u898f\u6a21\u6700\u5927\u3001\u8de8\u9818\u57df\u6700\u5b8c\u6574\u7684\u7cbe\u6e96\u91ab\u5b78\u7814\u7a76\u9ad4\u7cfb\u3002 \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u6821\u9577\u4f59\u660e\u9686\u8868\u793a\uff0c\u9ad8\u91ab\u9ad4\u7cfb\u9577\u5e74\u79c9\u6301\u300c\u4ee5\u4eba\u70ba\u672c\u300d\u7684\u5b97\u65e8\uff0c\u7d50\u5408\u81e8\u5e8a\u7167\u8b77\u8207\u79d1\u7814\u5275\u65b0\uff0c\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u8207\u667a\u6167\u5065\u5eb7\u7684\u843d\u5be6\u3002\u70ba\u63a8\u52d5\u5357\u90e8\u5730\u5340\u57fa\u56e0\u9ad4\u7814\u7a76\u767c\u5c55\uff0c\u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u4ea6\u65bc2019\u5e74\u6210\u7acb\u300c\u61c9\u7528\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u300d\uff0c\u6210\u70ba\u5357\u90e8\u552f\u4e00\u80fd\u7368\u7acb\u5b8c\u6210TPMI\u57fa\u56e0\u9ad4\u5206\u6790\u7684\u5718\u968a\uff0c\u9664\u4e86\u8ca0\u8cac\u9ad8\u91ab\u9ad4\u7cfb\u6aa2\u9ad4\u5916\uff0c\u66f4\u5354\u52a9\u4e2d\u7814\u9662\u8655\u7406\u5176\u4ed6\u5408\u4f5c\u91ab\u9662\u8d85\u904e3\u842c\u7b46\u6a23\u672c\u5206\u6790\uff0c\u7d2f\u7a4d\u6df1\u539a\u6280\u8853\u80fd\u91cf\uff0c\u5960\u5b9a\u570b\u5bb6\u7d1a\u7814\u7a76\u57fa\u5730\u7684\u5be6\u529b\u3002 \u9ad8\u96c4\u91ab\u5b78\u5927\u5b78\u9644\u8a2d\u4e2d\u548c\u7d00\u5ff5\u91ab\u9662\u738b\u7167\u5143\u9662\u9577\u5f37\u8abf\uff0cTPMI\u8a08\u756b\u662f\u53f0\u7063\u91ab\u5b78\u53f2\u4e0a\u7684\u91cd\u8981\u91cc\u7a0b\u7891\uff0c\u8c61\u5fb5\u8457\u53f0\u7063\u91ab\u5b78\u7814\u7a76\u5f9e\u300c\u8ffd\u96a8\u4e16\u754c\u300d\u9081\u5411\u300c\u5f15\u9818\u4e9e\u6d32\u300d\u3002\u904e\u53bb\u5168\u7403\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u5927\u591a\u6e90\u81ea\u6b50\u7f8e\u8cc7\u6599\u5eab\uff0c\u5c0d\u4e9e\u6d32\u4eba\u4e26\u4e0d\u7cbe\u6e96\uff0c\u4e2d\u7814\u9662\u651c\u624b\u9ad8\u91ab\u7b49\u91ab\u9662\u5efa\u7acb\u4ee5\u53f0\u7063\u4eba\u70ba\u6838\u5fc3\u7684\u57fa\u56e0\u8cc7\u6599\u5eab\uff0c\u6210\u529f\u958b\u767c\u51fa\u5c08\u5c6c\u65bc\u6f22\u4eba\u65cf\u7fa4\u7684\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u6a21\u578b\uff1b\u9019\u4e0d\u50c5\u8b93\u6211\u5011\u80fd\u66f4\u65e9\u767c\u73fe\u75be\u75c5\u98a8\u96aa\uff0c\u66f4\u8b93\u4e9e\u6d32\u4eba\u7b2c\u4e00\u6b21\u64c1\u6709\u5c6c\u65bc\u81ea\u5df1\u7684\u57fa\u56e0\u5065\u5eb7\u98a8\u96aa\u5730\u5716\u3002\u738b\u9662\u9577\u9032\u4e00\u6b65\u6307\u51fa\uff0c\u9ad8\u91ab\u4f5c\u70ba\u5927\u5b78\u9644\u8a2d\u91ab\u9662\u8207\u91ab\u5b78\u4e2d\u5fc3\uff0c\u4e0d\u50c5\u662f\u81e8\u5e8a\u91ab\u7642\u7684\u5148\u92d2\uff0c\u66f4\u662f\u63a8\u52d5\u570b\u5bb6\u7d1a\u79d1\u7814\u8a08\u756b\u7684\u91cd\u8981\u5f15\u64ce\u3002\u8fd1\u4e94\u5e74\u4f86\uff0c\u9ad8\u91ab\u5df2\u5b8c\u6210\u8d85\u904e500\u4ef6\u81e8\u5e8a\u8a66\u9a57\u6848\u3001\u7d2f\u7a4d\u8d85\u904e1,000\u4ef6\u570b\u969b\u5408\u4f5c\u7814\u7a76\uff0c\u4ee5\u81e8\u5e8a\u771f\u5be6\u4e16\u754c\u6578\u64da\u63a8\u52d5\u500b\u4eba\u5316\u91ab\u7642\u61c9\u7528\uff0c\u70ba\u5168\u6c11\u5065\u5eb7\u5efa\u7acb\u5805\u5be6\u57fa\u790e\u3002 \u9ad8\u91abTPMI\u8a08\u756b\u4e3b\u6301\u4eba\u9418\u80b2\u5fd7\u6559\u6388\u6307\u51fa\uff0c\u6b50\u7f8e\u65cf\u7fa4\u958b\u767c\u7684\u591a\u57fa\u56e0\u98a8\u96aa\u6a21\u578b\u82e5\u76f4\u63a5\u5957\u7528\u65bc\u4e9e\u6d32\u4eba\uff0c\u75be\u75c5\u98a8\u96aa\u9810\u6e2c\u504f\u5dee\u53ef\u905430%\u81f350%\uff0c\u9019\u9805\u7d50\u679c\u7a81\u986f\u51fa\u4e0d\u540c\u65cf\u7fa4\u7684\u907a\u50b3\u5dee\u7570\uff0c\u672a\u4f86\u7684\u7cbe\u6e96\u91ab\u7642\u5fc5\u9808\u5efa\u7acb\u5728\u591a\u5143\u65cf\u7fa4\u8cc7\u6599\u7684\u6574\u5408\u8207\u6bd4\u8f03\u4e4b\u4e0a\u3002\u9ad8\u91ab\u5c07\u6301\u7e8c\u8207\u4e2d\u7814\u9662\u53ca\u570b\u969b\u5b78\u8853\u5718\u968a\u5408\u4f5c\uff0c\u63a8\u52d5\u8de8\u65cf\u7fa4\u6578\u64da\u5171\u4eab\uff0c\u70ba\u5168\u7403\u7cbe\u6e96\u91ab\u5b78\u7684\u666e\u9069\u6027\u5960\u5b9a\u57fa\u790e\u3002 \u9ad8\u91abTPMI\u9f13\u52f5\u7d44\u6210\u8de8\u5718\u968a\u7814\u7a76\u5c0f\u7d44\uff0c\u7d50\u5408\u9ad8\u91ab\u6821\u9662\u8cc7\u6e90\uff0c\u5229\u7528TPMI\u8cc7\u6599\u5eab\u63a8\u52d5\u7cbe\u6e96\u91ab\u7642\u7684\u767c\u5c55\uff0c\u6df1\u5316\u81e8\u5e8a\u8207\u57fa\u790e\u7814\u7a76\u7684\u6574\u5408\u80fd\u91cf\u3002\u9019\u4e9b\u8de8\u5718\u968a\u5408\u4f5c\u4fc3\u9032\u81e8\u5e8a\u91ab\u5e2b\u8207\u57fa\u790e\u7814\u7a76\u8005\u7684\u4ea4\u6d41\uff0c\u4e26\u7d50\u5408\u57fa\u56e0\u9ad4\u5b78\u3001\u86cb\u767d\u8cea\u9ad4\u5b78\u8207\u81e8\u5e8a\u8cc7\u6599\u5206\u6790\uff0c\u63a2\u7d22\u75be\u75c5\u6a5f\u8f49\u3001\u85e5\u7269\u53cd\u61c9\u5dee\u7570\u8207\u65e9\u671f\u8a3a\u65b7\u6307\u6a19\uff0c\u63a8\u52d5\u5177\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u7684\u7814\u7a76\u6210\u679c\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u4e3b\u5c0e\u76843\u7bc7TPMI\u4e3b\u8981\u8ad6\u6587\u53ca1\u7bc7\u8207\u570b\u5916\u5718\u968a\u5408\u4f5c\u7684\u8ad6\u6587\uff0c\u9ad8\u91ab\u5718\u968a\u517130\u540d\u81e8\u5e8a\u91ab\u5e2b\u4ee3\u8868\u53c3\u8207\uff0c\u5206\u5225\u70ba\u767c\u8868\u5728\u300aNature\u300b\u7684\u300aThe Taiwan precision medicine initiative: a cohort for large-scale studies\u300b\u3001\u300aNature\u300b\u7684\u300aPopulation-specific polygenic risk scores developed for the Han Chinese\u300b\u3001\u300aNature Communications\u300b\u7684\u300aClinical impact of pharmacogenetic risk variants in a large Chinese cohort\u300b\u3001\u300aScience\u300b\u7684\u300aKidney multiome-based genetic scorecard reveals convergent coding and regulatory variants\u300b\uff1b\u4e26\u67097\u4f4d\u9ad8\u91ab\u9ad4\u7cfbTPMI\u5171\u540c\u4e3b\u6301\u4eba\u4ea6\u64d4\u4efb\u4e2d\u7814\u9662TPMI\u7814\u7a76\u5c0f\u7d44\u53ec\u96c6\u4eba\uff0c\u6db5\u84cb\u738b\u7167\u5143\u91ab\u5e2b\u300c\u5927\u8178\u76f4\u8178\u816b\u7624\u53ca\u817a\u7624\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9418\u80b2\u5fd7\u91ab\u5e2b\u300c\u795e\u7d93\u808c\u8089\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5433\u6587\u6b63\u91ab\u5e2b\u300c\u6ccc\u5c3f\u7cfb\u7d71\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9ec3\u5fd7\u5bcc\u91ab\u5e2b\u300cC\u578b\u809d\u708e\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u5f90\u5d07\u582f\u91ab\u5e2b\u300c\u7761\u7720\u969c\u7919\u8207\u7672\u7647\u7814\u7a76\u5c0f\u7d44\u300d\u3001\u9673\u5d07\u6853\u91ab\u5e2b\u300c\u9ad6\u90e8\u75be\u75c5\u7814\u7a76\u5c0f\u7d44\u300d\uff0c\u4ee5\u53ca\u90ed\u662d\u5b8f\u91ab\u5e2b\u300c\u74b0\u5883\u6c59\u67d3\u7814\u7a76\u5c0f\u7d44\u300d\u3002 \u9ad8\u91abTPMI\u7814\u7a76\u5718\u968a\u805a\u7126\u591a\u9805\u81e8\u5e8a\u75be\u75c5\u7814\u7a76\u9818\u57df\u4e26\u9678\u7e8c\u7522\u51fa\u6210\u679c\u3002\u4f8b\u5982\uff0c\u795e\u7d93\u5167\u79d1\u694a\u6df5\u97d3\u91ab\u5e2b\u5718\u968a\u91dd\u5c0d\u5e74\u9f61\u3001\u6027\u5225\u8207APOE \u57fa\u56e0\u5728\u963f\u8332\u6d77\u9ed8\u75c7\u4e2d\u7684\u95dc\u806f\u6027\u9032\u884c\u7814\u7a76\u3002APOE4 \u57fa\u56e0\u88ab\u516c\u8a8d\u70ba\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u91cd\u8981\u98a8\u96aa\u57fa\u56e0\u3002\u9ad8\u91ab\u5931\u667a\u7814\u7a76\u5718\u968a\u6536\u7d0d\u8fd11,800 \u4f4d\u6b63\u5e38\u53d7\u8a66\u8005\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u5728\u53f0\u7063\u65cf\u7fa4\u4e2d\uff0cAPOE4 \u57fa\u56e0\u65bc 75 \u6b72\u4ee5\u4e0a\u7537\u6027\u60a3\u8005\u7684\u5f71\u97ff\u529b\u5927\u65bc\u5973\u6027\uff1b\u800c\u572875 \u6b72\u4ee5\u4e0b\u60a3\u8005\u4e2d\uff0c\u5c0d\u5973\u6027\u7684\u5f71\u97ff\u529b\u5247\u9ad8\u65bc\u7537\u6027\u3002\u76f8\u95dc\u7814\u7a76\u7d50\u679c\u4e5f\u5df2\u767c\u8868\u65bc\u570b\u969b\u671f\u520a\u3002 \u5728\u81e8\u5e8a\u61c9\u7528\u8207\u6578\u4f4d\u5316\u670d\u52d9\u65b9\u9762\uff0c\u9ad8\u91ab\u70ba\u4e86\u5354\u52a9\u81e8\u5e8a\u91ab\u5e2b\u6c7a\u7b56\u8207\u63d0\u5347\u75c5\u4eba\u7528\u85e5\u5b89\u5168\uff0c\u6253\u9020\u300cTPMI\u85e5\u7269\u63d0\u793a\u7cfb\u7d71\u300d\uff0c\u4e26\u4e14\u898f\u5283TPMI\u53c3\u8207\u8005\u53ef\u900f\u904e\u9ad8\u91ab\u5b98\u7db2\u300cTPMI\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u5c08\u5340\u300d\u5e73\u53f0\u67e5\u8a62\u500b\u4eba\u7814\u7a76\u5206\u6790\u7d50\u679c\uff0c\u8b93\u53c3\u8207\u8005\u66f4\u7406\u89e3\u81ea\u8eab\u5065\u5eb7\u98a8\u96aa\u8207\u751f\u6d3b\u7ba1\u7406\u5efa\u8b70\u3002\u5c0d\u7814\u7a76\u5206\u6790\u7d50\u679c\u6709\u9032\u4e00\u6b65\u8aee\u8a62\u9700\u6c42\u7684TPMI\u53c3\u8207\u8005\uff0c\u53ef\u4ee5\u900f\u904e\u806f\u7e6b\u9ad8\u91abTPMI\u5718\u968a\uff0c\u5a92\u5408\u9069\u5408\u7684\u81e8\u5e8a\u79d1\u5225\u6216\u5177\u85e5\u7269\u57fa\u56e0\u9ad4\u5c08\u696d\u7684\u85e5\u5e2b\u9032\u884c\u66f4\u5c08\u696d\u7684\u907a\u50b3\u3001\u7528\u85e5\u8aee\u8a62\u3002\u9ad8\u91ab\u7a4d\u6975\u6295\u5165TPMI\u7814\u7a76\uff0c\u4e0d\u50c5\u8b93\u5357\u53f0\u7063\u6210\u70ba\u7cbe\u6e96\u91ab\u7642\u91cd\u93ae\uff0c\u66f4\u8b93\u53f0\u7063\u7684\u79d1\u7814\u6210\u679c\u767b\u4e0a\u570b\u969b\u821e\u53f0\uff0c\u672a\u4f86\uff0c\u9ad8\u91ab\u5c07\u6301\u7e8c\u6574\u5408\u81e8\u5e8a\u3001\u5b78\u8853\u8207\u79d1\u6280\u80fd\u91cf\uff0c\u8b93\u6bcf\u4e00\u4f4d\u6c11\u773e\u90fd\u80fd\u4eab\u6709\u5b89\u5168\u3001\u6709\u6548\u4e14\u5c08\u5c6c\u7684\u5065\u5eb7\u7167\u8b77\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=374674"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/b6333fc108300ffcc8b8078a31c68e79.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/b6333fc108300ffcc8b8078a31c68e79.jpg","width":2398,"height":1748},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=374674#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u9ad8\u91ab\u5718\u968a\u7a4d\u6975\u53c3\u8207\u300c\u53f0\u7063\u7cbe\u6e96\u91ab\u7642\u8a08\u756b\u300d\u3000\u6210\u679c\u69ae\u767b\u300aNature\u300b\u300aScience\u300b\u7b49\u570b\u969b\u9802\u5c16\u671f\u520a"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/0d1424ad2931c0f1cf112f3b4a70a2fb","name":"Press Chou","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/4f9dd0fcd64425dde81c6b2e687c3ea616db5a05deade1f65dfc2fdf196b2512?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/4f9dd0fcd64425dde81c6b2e687c3ea616db5a05deade1f65dfc2fdf196b2512?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/4f9dd0fcd64425dde81c6b2e687c3ea616db5a05deade1f65dfc2fdf196b2512?s=96&d=blank&r=g","caption":"Press Chou"},"url":"https:\/\/pingtungtimes.com.tw\/?author=4"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/374674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=374674"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/374674\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/374675"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=374674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=374674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=374674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}