{"id":373118,"date":"2025-10-17T22:00:00","date_gmt":"2025-10-17T14:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=373118"},"modified":"2025-10-17T22:00:00","modified_gmt":"2025-10-17T14:00:00","slug":"%e6%99%ae%e7%9c%be%e7%99%bc%e7%8f%be%e5%9c%a82025%e5%b9%b4%e6%ad%90%e6%b4%b2%e8%85%ab%e7%98%a4%e5%85%a7%e7%a7%91%e5%ad%b8%e6%9c%83%ef%bc%88esmo%ef%bc%89%e4%b8%8a%e5%85%ac%e4%bd%88%e5%85%b6%e6%8a%97cd4","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=373118","title":{"rendered":"\u666e\u773e\u767c\u73fe\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u4e0a\u516c\u4f48\u5176\u6297CD44v9 ADC\uff08AMT-116\uff09\u7528\u65bc\u665a\u671fEGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u7684\u521d\u6b65\u7a4d\u6975\u6578\u64da"},"content":{"rendered":"
\n

AMT-116\u662f\u4e00\u6b3e\u6f5b\u5728\u5168\u7403\u9996\u5275\u7684\u9776\u5411CD44v9\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269<\/i>
AMT-116\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4e3b\u8981\u662f\u53ef\u63a7\u7684\u8840\u6db2\u5b78\u6bd2\u6027\u548c\u6d88\u5316\u7cfb\u7d71\u76f8\u95dc\u6bd2\u6027\u00a0<\/i>
\u5728\u672a\u7d93CD44v9\u8868\u9054\u7be9\u9078\u3001\u7d93\u591a\u7dda\u6cbb\u7642\u7684EGFR\u91ce\u751f\u578bNSCLC\u548c\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u89c0\u5bdf\u5230\u7a4d\u6975\u7642\u6548\u4fe1\u865f<\/i><\/p>\n

\u4e0a\u6d77<\/span>2025\u5e7410\u670817\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —\u00a0\u666e\u773e\u767c\u73fe\uff08Multitude Therapeutics, Inc.\uff09\uff0c\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bcADC\u85e5\u7269\u958b\u767c\u7684\u81e8\u5e8a\u968e\u6bb5\u516c\u53f8\u3002\u4eca\u65e5\u516c\u4f48\u4e86\u5176\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7814\u7a76\u7684\u521d\u6b65\u6578\u64da\u3002\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u6f5b\u5728\u5168\u7403\u9996\u5275\u7684\u9776\u5411CD44v9\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269AMT-116\u5728EGFR\u91ce\u751f\u578bNSCLC\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u8a72\u6578\u64da\u65bc\u4eca\u65e5\u5728\u5fb7\u570b\u67cf\u6797\u8209\u884c\u76842025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u4e0a\u767c\u4f48\u3002<\/p>\n

\u9019\u9805\u81e8\u5e8aI\/II\u671f\u9996\u6b21\u4eba\u9ad4\u8a66\u9a57\u5728\u6fb3\u6d32\u3001\u7f8e\u570b\u548c\u4e2d\u570b\u958b\u5c55\u3002\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u8a55\u4f30AMT-116\u5728\u665a\u671f\u5be6\u9ad4\u7624\u53d7\u8a66\u8005\u4e2d\u7684\u6700\u5927\u8010\u53d7\u5291\u91cf\/\u63a8\u85a6II\u671f\u5291\u91cf\u3001\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u514d\u75ab\u539f\u6027\u53ca\u521d\u6b65\u7642\u6548\u3002Ia\u671f\u5c07\u78ba\u5b9a\u64f4\u5c55\u968e\u6bb5\u7684\u63a8\u85a6\u5291\u91cf\uff0cIb\/II\u671f\u5c07\u8457\u91cd\u5728\u9078\u5b9a\u816b\u7624\u985e\u578b\u4e2d\u9032\u4e00\u6b65\u8a55\u4f30AMT-116\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002<\/p>\n

\u622a\u81f32025\u5e747\u670817\u65e5\uff0c\u5df2\u6709164\u4f8b\u53d7\u8a66\u8005\u7684\u6578\u64da\u53ef\u4f9b\u5206\u6790\u5b89\u5168\u6027\u3002\u9019\u4e9b\u53d7\u8a66\u8005\u63a5\u53d7\u6bcf\u5169\u9031\u4e00\u6b21\uff08Q2W\uff09\u7684AMT-116\u6cbb\u7642\uff0c\u5291\u91cf\u7bc4\u570d\u70ba1.5\u81f35.0 mg\/kg\u3002\u5165\u7d44\u7684\u53d7\u8a66\u8005\u4e3b\u8981\u70ba NSCLC\u3001\u9f3b\u54bd\u764c\u3001\u809b\u9580\u9c57\u764c\u548c\u553e\u6db2\u817a\u764c\u7b49\u3002\u5165\u7d44\u7684EGFR\u91ce\u751f\u578bNSCLC\u65e2\u5f80\u63a5\u53d7\u904e1-5\u7dda\u7684\u6cbb\u7642\uff0c\u5728\u672a\u7d93CD44v9\u8868\u9054\u7be9\u9078\u3001\u4e14\u7d93\u591a\u7dda\u6cbb\u7642\u7684EGFR\u91ce\u751f\u578bNSCLC\u53d7\u8a66\u8005\u4e2d\u89c0\u5bdf\u5230\u7a4d\u6975\u7684\u7642\u6548\u4fe1\u865f\u3002\u5728\u22653.0mg\/kg\u7684EGFR\u91ce\u751f\u578bNSCLC\u53d7\u8a66\u8005\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba40%\uff086\/15\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba93%\uff0814\/15\uff09\u3002\u57285.0 mg\/kg\u7684EGFR\u91ce\u751f\u578bNSCLC\u53d7\u8a66\u8005\u7684ORR\u70ba80%\uff084\/5\uff09\uff0cDCR\u70ba100%\uff085\/5\uff09\u3002\u540c\u6642\uff0c\u5728\u9f3b\u54bd\u764c\u3001\u809b\u9580\u764c\u548c\u553e\u6db2\u817a\u764c\u4ea6\u770b\u5230\u521d\u6b65\u7642\u6548\uff0c\u5728\u22653.0mg\/kg \u5291\u91cf\u4e0b\uff0cORR\u5206\u5225\u70ba50% (3\/6), 60% (3\/5) \u548c 33% (2\/6)\u3002\u5728\u4e0d\u540cCD44v9\u8868\u9054\u6c34\u5e73\u7684\u60a3\u8005\u4e2d\u5747\u89c0\u5bdf\u5230\u6297\u816b\u7624\u6d3b\u6027\u3002AMT-116\u5b89\u5168\u6027\u548c\u5176\u4ed6TOP1\u6291\u5236\u5291\u985eADC\u4e00\u81f4\uff0c\u6700\u5e38\u898b\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u53ef\u63a7\u7684\u8840\u6db2\u5b78\u6bd2\u6027\u3002\u50c5\u89c0\u5bdf\u5230\u4f4e\u7d1a\u5225\u4e14\u5c11\u91cf\u7684\u53e3\u8154\u9ecf\u819c\u53ca\u76ae\u819a\u6bd2\u6027\u767c\u751f\uff0c\u986f\u793a\u5176\u826f\u597d\u7684\u53ef\u8010\u53d7\u6027\u3002<\/p>\n

\u666e\u773e\u767c\u73fe\u806f\u5408\u5275\u59cb\u4eba\u517c\u9996\u5e2d\u79d1\u5b78\u5b98\u5289\u6dd1\u60e0\u535a\u58eb\u8868\u793a\uff1a\u300cAMT-116\u7684\u65e9\u671f\u81e8\u5e8a\u7d50\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u5c24\u5176\u662f\u5728EGFR\u91ce\u751f\u578bNSCLC\u548c\u591a\u500b\u665a\u671f\u5be6\u9ad4\u7624\u968a\u5217\u4e2d\u89c0\u5bdf\u5230\u7684\u7a4d\u6975\u7642\u6548\u2014\u2014\u5165\u7d44\u7684\u53d7\u8a66\u8005\u5747\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u4e14\u672a\u7d93CD44v9\u8868\u9054\u6c34\u5e73\u7be9\u9078\u3002\u9019\u4e9b\u6578\u64da\u8207\u81e8\u5e8a\u524d\u7d50\u679c\u4e00\u81f4\uff0c\u5171\u540c\u5370\u8b49\u4e86AMT-116\u5728\u5be6\u9ad4\u7624\u4e2d\u7684\u5ee3\u6cdb\u8868\u9054\u3002\u540c\u6642\uff0c\u53e3\u8154\u9ecf\u819c\u548c\u76ae\u819a\u6bd2\u6027\u986f\u8457\u964d\u4f4e\uff0c\u53cd\u6620\u4e86\u7cbe\u5fc3\u8a2d\u8a08\u7684\u9023\u63a5\u5b50-\u8f09\u8377\u5e73\u53f0\u6240\u671f\u671b\u7684\u76ee\u6a19\u2014\u2014\u5373\u6e1b\u5c11\u6b63\u5e38\u7d44\u7e54\u8868\u9054\u5f15\u767c\u7684\u300c\u5728\u9776\u6bd2\u6027\u300d\u3002\u57fa\u65bc\u9019\u4e9b\u7a4d\u6975\u7d50\u679c\uff0c\u6211\u5011\u6b63\u9032\u4e00\u6b65\u57284.0 mg\/kg\uff08Q2W\uff09\u548c5.0 mg\/kg\uff08Q2W\uff09\u5291\u91cf\u7d44\u9032\u884c\u64f4\u5c55\u7814\u7a76\uff0c\u4ee5\u5145\u5206\u6316\u6398\u9019\u6b3e\u5168\u65b0\u7684ADC\u7684\u6f5b\u529b\uff0c\u70baNSCLC\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u76ca\u8655\u3002\u300d<\/p>\n

\u53e3\u982d\u532f\u5831\u5c55\u793a\u8a73\u60c5\uff1a<\/b><\/p>\n

\u6a19\u984c\uff1a<\/b>Updated ongoing Phase I\/II clinical trial results of AMT-116, a first-in-class anti-CD44v9 antibody-drug conjugate (ADC), in patients with advanced solid tumors<\/p>\n

\u53e3\u982d\u532f\u5831\u5c08\u984c\uff1a<\/b> Developmental therapeutics<\/p>\n

\u6642\u9593\uff1a<\/b> 2025\u5e7410\u670817\u65e5 \u2013 04:05 PM\uff08\u6b50\u6d32\u4e2d\u90e8\u6642\u9593\uff09<\/p>\n

\u5730\u9ede\uff1a<\/b>Heidelberg Auditorium – Hall 6.2<\/p>\n

\u53e3\u982d\u532f\u5831\u7de8\u865f\uff1a<\/b>922MO<\/p>\n

\u95dc\u65bcAMT-116<\/b>
AMT-116\u662f\u4e00\u6b3e\u9776\u5411CD44v9\u7684ADC\u3002AMT-116\u7684\u7d50\u69cb\u7d44\u6210\u70ba\uff1a\u8207CD44v9\u5177\u6709\u9ad8\u7d50\u5408\u89aa\u548c\u529b\u7684\u5c08\u6709\u6297\u9ad4\u3001\u53ef\u6c34\u89e3\u7684\u9023\u63a5\u5b50\uff0c\u4ee5\u53ca\u8c9d\u6d1b\u66ff\u5eb7\u884d\u751f\u7269\u6709\u6548\u8f09\u8377\uff08\u4e00\u7a2e\u7d93\u904e\u81e8\u5e8a\u9a57\u8b49\u3001\u6709\u6548\u7684\u62d3\u64b2\u7570\u69cb\u9176-1\u6291\u5236\u5291\uff0cKL610023\uff0c\u7531\u56db\u5ddd\u79d1\u502b\u535a\u6cf0\u751f\u7269\u91ab\u85e5\u80a1\u4efd\u6709\u9650\u516c\u53f8(6990.HK)\u958b\u767c\uff09\u3002CD44v9\u53c3\u8207\u5ee3\u6cdb\u7684\u751f\u7269\u4fe1\u865f\u901a\u8def\uff0c\u5c0d\u816b\u7624\u5e72\u7d30\u80de\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u8a72\u9776\u9ede\u662f\u9ad8\u4e30\u5ea6\u7d30\u80de\u819c\u86cb\u767d\uff0c\u4e14\u5ee3\u6cdb\u904e\u5ea6\u8868\u9054\u65bc\u5be6\u9ad4\u7624\uff0c\u4f46\u5728\u6b63\u5e38\u7d44\u7e54\u4e2d\u8868\u9054\u53d7\u9650\u3002AMT-116\u7684\u85e5\u7269\u6297\u9ad4\u6bd4\u503c\u7d04\u70ba7-8\u3002\u76ee\u524d\u6b63\u901a\u904eI\/II\u671f\u81e8\u5e8a\u8a66\u9a57\u5c0d\u5176\u5728EGFR\u91ce\u751f\u578bNSCLC\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u9032\u884c\u8a55\u4f30\u3002\u5982\u9700\u77ad\u89e3\u66f4\u591a\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9eI\u671f\u81e8\u5e8a\u8a66\u9a57 (NCT05725291) \u548c\u4e2d\u570bI\/II\u671f\u81e8\u5e8a\u8a66\u9a57(NCT06782334)\u4fe1\u606f\uff0c\u53ef\u767b\u9304http:\/\/clinicaltrials.gov<\/a>\u67e5\u8a62\u3002<\/p>\n

\u95dc\u65bc\u666e\u773e\u767c\u73fe<\/b>
\u666e\u773e\u767c\u73fe\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bcADC\u85e5\u7269\u958b\u767c\u7684\u81e8\u5e8a\u968e\u6bb5\u516c\u53f8\u3002\u666e\u773e\u767c\u73fe\u4f7f\u7528\u4e86\u5169\u500b\u6280\u8853\u5e73\u53f0\uff1aMabArray\u2014\u2014 \u4e00\u7a2e\u7528\u65bc\u767c\u73fe\u65b0\u7a4e\u7684\u7d30\u80de\u8868\u9762\u6297\u816b\u7624\u9776\u9ede\u4ee5\u69cb\u5efa\u5168\u65b0\u9776\u6a19(First-in-Class)\u7684\u6297\u9ad4\u5e73\u53f0\uff0c\u4ee5\u53caT1000 \u2014\u2014 \u4e00\u7a2e\u7528\u65bc\u958b\u767cADC\u7684\u65b0\u578b\u9023\u63a5\u5b50-\u6709\u6548\u8f09\u8377\u6280\u8853\uff0c\u5229\u7528\u8a72\u5e73\u53f0\u5236\u5099\u7684ADC\u5728\u65c1\u89c0\u8005\u6548\u61c9\u3001\u7642\u6548\u548c\u5b89\u5168\u6027\u65b9\u9762\u80fd\u5920\u7372\u5f97\u66f4\u512a\u5316\u7684\u5e73\u8861\u3002MabArray\u8207T1000\u7684\u7d50\u5408\u7522\u751f\u4e86\u986f\u8457\u7684\u5354\u540c\u6548\u61c9\uff0c\u4f7f\u666e\u773e\u767c\u73fe\u80fd\u5920\u69cb\u5efa\u4e00\u5957ADC\u300c\u5716\u518a\u300d\uff0c\u8a72\u300c\u5716\u518a\u300d\u6709\u671b\u7528\u65bc\u6cbb\u7642\u5177\u6709\u9ad8\u5ea6\u672a\u6eff\u8db3\u6cbb\u7642\u9700\u6c42\u7684\u60e1\u6027\u816b\u7624\uff0c\u4e26\u5be6\u73fe\u66f4\u9ad8\u548c\u66f4\u6301\u4e45\u7684\u97ff\u61c9\u3002<\/p>\n

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AMT-116\u662f\u4e00\u6b3e\u6f5b\u5728\u5168\u7403\u9996…<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-373118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u666e\u773e\u767c\u73fe\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u4e0a\u516c\u4f48\u5176\u6297CD44v9 ADC\uff08AMT-116\uff09\u7528\u65bc\u665a\u671fEGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u7684\u521d\u6b65\u7a4d\u6975\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" 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property=\"og:title\" content=\"\u666e\u773e\u767c\u73fe\u57282025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u4e0a\u516c\u4f48\u5176\u6297CD44v9 ADC\uff08AMT-116\uff09\u7528\u65bc\u665a\u671fEGFR\u91ce\u751f\u578b\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u7684\u521d\u6b65\u7a4d\u6975\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"AMT-116\u662f\u4e00\u6b3e\u6f5b\u5728\u5168\u7403\u9996\u5275\u7684\u9776\u5411CD44v9\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269AMT-116\u5c55\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u4e3b\u8981\u662f\u53ef\u63a7\u7684\u8840\u6db2\u5b78\u6bd2\u6027\u548c\u6d88\u5316\u7cfb\u7d71\u76f8\u95dc\u6bd2\u6027\u00a0\u5728\u672a\u7d93CD44v9\u8868\u9054\u7be9\u9078\u3001\u7d93\u591a\u7dda\u6cbb\u7642\u7684EGFR\u91ce\u751f\u578bNSCLC\u548c\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u4e2d\u89c0\u5bdf\u5230\u7a4d\u6975\u7642\u6548\u4fe1\u865f \u4e0a\u6d772025\u5e7410\u670817\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u666e\u773e\u767c\u73fe\uff08Multitude Therapeutics, Inc.\uff09\uff0c\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bcADC\u85e5\u7269\u958b\u767c\u7684\u81e8\u5e8a\u968e\u6bb5\u516c\u53f8\u3002\u4eca\u65e5\u516c\u4f48\u4e86\u5176\u6b63\u5728\u9032\u884c\u7684I\/II\u671f\u958b\u653e\u6a19\u7c64\u3001\u591a\u4e2d\u5fc3\u3001\u5291\u91cf\u905e\u589e\u53ca\u64f4\u5c55\u7814\u7a76\u7684\u521d\u6b65\u6578\u64da\u3002\u8a72\u7814\u7a76\u65e8\u5728\u8a55\u4f30\u6f5b\u5728\u5168\u7403\u9996\u5275\u7684\u9776\u5411CD44v9\u7684\u6297\u9ad4\u5076\u806f\u85e5\u7269AMT-116\u5728EGFR\u91ce\u751f\u578bNSCLC\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u7642\u6548\u3002\u8a72\u6578\u64da\u65bc\u4eca\u65e5\u5728\u5fb7\u570b\u67cf\u6797\u8209\u884c\u76842025\u5e74\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\uff08ESMO\uff09\u4e0a\u767c\u4f48\u3002 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\u622a\u81f32025\u5e747\u670817\u65e5\uff0c\u5df2\u6709164\u4f8b\u53d7\u8a66\u8005\u7684\u6578\u64da\u53ef\u4f9b\u5206\u6790\u5b89\u5168\u6027\u3002\u9019\u4e9b\u53d7\u8a66\u8005\u63a5\u53d7\u6bcf\u5169\u9031\u4e00\u6b21\uff08Q2W\uff09\u7684AMT-116\u6cbb\u7642\uff0c\u5291\u91cf\u7bc4\u570d\u70ba1.5\u81f35.0 mg\/kg\u3002\u5165\u7d44\u7684\u53d7\u8a66\u8005\u4e3b\u8981\u70ba NSCLC\u3001\u9f3b\u54bd\u764c\u3001\u809b\u9580\u9c57\u764c\u548c\u553e\u6db2\u817a\u764c\u7b49\u3002\u5165\u7d44\u7684EGFR\u91ce\u751f\u578bNSCLC\u65e2\u5f80\u63a5\u53d7\u904e1-5\u7dda\u7684\u6cbb\u7642\uff0c\u5728\u672a\u7d93CD44v9\u8868\u9054\u7be9\u9078\u3001\u4e14\u7d93\u591a\u7dda\u6cbb\u7642\u7684EGFR\u91ce\u751f\u578bNSCLC\u53d7\u8a66\u8005\u4e2d\u89c0\u5bdf\u5230\u7a4d\u6975\u7684\u7642\u6548\u4fe1\u865f\u3002\u5728\u22653.0mg\/kg\u7684EGFR\u91ce\u751f\u578bNSCLC\u53d7\u8a66\u8005\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba40%\uff086\/15\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba93%\uff0814\/15\uff09\u3002\u57285.0 mg\/kg\u7684EGFR\u91ce\u751f\u578bNSCLC\u53d7\u8a66\u8005\u7684ORR\u70ba80%\uff084\/5\uff09\uff0cDCR\u70ba100%\uff085\/5\uff09\u3002\u540c\u6642\uff0c\u5728\u9f3b\u54bd\u764c\u3001\u809b\u9580\u764c\u548c\u553e\u6db2\u817a\u764c\u4ea6\u770b\u5230\u521d\u6b65\u7642\u6548\uff0c\u5728\u22653.0mg\/kg \u5291\u91cf\u4e0b\uff0cORR\u5206\u5225\u70ba50% (3\/6), 60% (3\/5) \u548c 33% (2\/6)\u3002\u5728\u4e0d\u540cCD44v9\u8868\u9054\u6c34\u5e73\u7684\u60a3\u8005\u4e2d\u5747\u89c0\u5bdf\u5230\u6297\u816b\u7624\u6d3b\u6027\u3002AMT-116\u5b89\u5168\u6027\u548c\u5176\u4ed6TOP1\u6291\u5236\u5291\u985eADC\u4e00\u81f4\uff0c\u6700\u5e38\u898b\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u70ba\u53ef\u63a7\u7684\u8840\u6db2\u5b78\u6bd2\u6027\u3002\u50c5\u89c0\u5bdf\u5230\u4f4e\u7d1a\u5225\u4e14\u5c11\u91cf\u7684\u53e3\u8154\u9ecf\u819c\u53ca\u76ae\u819a\u6bd2\u6027\u767c\u751f\uff0c\u986f\u793a\u5176\u826f\u597d\u7684\u53ef\u8010\u53d7\u6027\u3002 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mg\/kg\uff08Q2W\uff09\u548c5.0 mg\/kg\uff08Q2W\uff09\u5291\u91cf\u7d44\u9032\u884c\u64f4\u5c55\u7814\u7a76\uff0c\u4ee5\u5145\u5206\u6316\u6398\u9019\u6b3e\u5168\u65b0\u7684ADC\u7684\u6f5b\u529b\uff0c\u70baNSCLC\u53ca\u5176\u4ed6\u665a\u671f\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u76ca\u8655\u3002\u300d \u53e3\u982d\u532f\u5831\u5c55\u793a\u8a73\u60c5\uff1a \u6a19\u984c\uff1aUpdated ongoing Phase I\/II clinical trial results of AMT-116, a first-in-class anti-CD44v9 antibody-drug conjugate (ADC), in patients with advanced solid tumors \u53e3\u982d\u532f\u5831\u5c08\u984c\uff1a Developmental therapeutics \u6642\u9593\uff1a 2025\u5e7410\u670817\u65e5 \u2013 04:05 PM\uff08\u6b50\u6d32\u4e2d\u90e8\u6642\u9593\uff09 \u5730\u9ede\uff1aHeidelberg Auditorium - Hall 6.2 \u53e3\u982d\u532f\u5831\u7de8\u865f\uff1a922MO 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