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2025\u5e7410\u67089\u65e5\uff0c\u5fa9\u5b8f\u6f22\u9716\uff082696.HK\uff09\u5ba3\u4f48\u516c\u53f8\u81ea\u7814\u5275\u65b0\u578bPD-1\u6291\u5236\u5291H\u85e5 \u6f22\u65af\u72c0<sup>\u00ae<\/sup>\uff08\u65af\u9b6f\u5229\u55ae\u6297\uff0c\u6b50\u6d32\u5546\u54c1\u540d\uff1aHetronifly<sup>\u00ae<\/sup>\uff09\u806f\u5408\u5316\u7642\u65b0\u8f14\u52a9\/\u55ae\u85e5\u8f14\u52a9\u6cbb\u7642\u80c3\u764c\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08ASTRUM-006\uff09\u671f\u4e2d\u5206\u6790\u9054\u5230\u4e86\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\uff0c\u6210\u70ba\u5168\u7403\u9996\u500b\u80c3\u764c\u570d\u8853\u671f\uff08\u8853\u524d\/\u8853\u5f8c\uff09\u4ee5\u514d\u75ab\u55ae\u85e5\u53d6\u4ee3\u8853\u5f8c\u8f14\u52a9\u5316\u7642\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u5be6\u73fe\u4e86\u8a72\u9818\u57df\u7684\u91cd\u5927\u7a81\u7834\u3002<\/p>\n<p 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IDMC\uff09\u7684\u671f\u4e2d\u5206\u6790\u7d50\u679c\u986f\u793a\uff1a\u8a72\u7814\u7a76\u9054\u5230\u9810\u8a2d\u7684\u512a\u6548\u6027\u6a19\u6e96\u3002\u8207\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u76f8\u6bd4\uff0c\u6f22\u65af\u72c0<sup>\u00ae<\/sup>\u806f\u5408\u5316\u7642\u986f\u8457\u6539\u5584EFS\uff0c\u75c5\u7406\u5b8c\u5168\u7de9\u89e3\uff08pCR\uff09\u7387\u662f\u5c0d\u7167\u7d443\u500d\u591a\uff0c\u60a3\u8005\u5fa9\u767c\u98a8\u96aa\u660e\u986f\u964d\u4f4e\u3002\u540c\u6642\uff0c\u8a72\u6cbb\u7642\u65b9\u6848\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u57fa\u65bc\u9019\u4e00\u7a4d\u6975\u7d50\u679c\uff0c\u5efa\u8b70\u63d0\u524d\u7533\u5831\u4e0a\u5e02\u3002<\/p>\n<p 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class=\"prntaj\">\u672a\u4f86\uff0c\u5fa9\u5b8f\u6f22\u9716\u5c07\u4f9d\u6258\u7522\u54c1\u7ba1\u7dda\u7684\u591a\u5c64\u6b21\u5275\u65b0\u7642\u6cd5\u77e9\u9663\uff0c\u4ee5\u53ca\u8c50\u5bcc\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6301\u7e8c\u6df1\u5316\u5728\u6d88\u5316\u9053\u816b\u7624\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u81f4\u529b\u65bc\u5c07\u66f4\u591a\u512a\u8cea\u6cbb\u7642\u65b9\u6848\u63a8\u5411\u5168\u7403\uff0c\u60e0\u53ca\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[1] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2024;74(3):229-263.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[2] \u9ad8\u6893\u8317\uff0c\u5f90\u60e0\u7dbf. \u65b0\u8f14\u52a9\u6cbb\u7642\u8207\u8f49\u5316\u6cbb\u7642\u2014\u2014\u63a2\u7d22\u9069\u5408\u4e2d\u570b\u80c3\u764c\u60a3\u8005\u7684\u570d\u624b\u8853\u671f\u6cbb\u7642\u6a21\u5f0f[J]. \u4e2d\u83ef\u91ab\u5b78\u4fe1\u606f\u5c0e\u5831\uff0c2021, 36(3): 17-17.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[3] Issafras H, et al. Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy. PLoS One. 2021;16(12):e0257972.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[4] Hui E, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355(6332):1428-1433.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[5] Patsoukis N, et al. Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020;3(1):128.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[6] Fenwick C, et al. Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. J Exp Med. 2019;216(7):1525-1541.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnews_p\"><span class=\"prnews_span\">[7] Primavera E, et al. Computer-Aided Identification of Kinase-Targeted Small Molecules for Cancer: A Review on AKT Protein. Pharmaceuticals (Basel). 2023;16(7):993.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p class=\"prntaj\">\u00a0<\/p>\n<p class=\"prntaj\"><b>\u95dc\u65bc\u5fa9\u5b8f\u6f22\u9716<\/b><\/p>\n<p 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\u672a\u4f86\uff0c\u5fa9\u5b8f\u6f22\u9716\u5c07\u4f9d\u6258\u7522\u54c1\u7ba1\u7dda\u7684\u591a\u5c64\u6b21\u5275\u65b0\u7642\u6cd5\u77e9\u9663\uff0c\u4ee5\u53ca\u8c50\u5bcc\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6301\u7e8c\u6df1\u5316\u5728\u6d88\u5316\u9053\u816b\u7624\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u81f4\u529b\u65bc\u5c07\u66f4\u591a\u512a\u8cea\u6cbb\u7642\u65b9\u6848\u63a8\u5411\u5168\u7403\uff0c\u60e0\u53ca\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u3002                  \u3010\u53c3\u8003\u6587\u737b\u3011         Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2024;74(3):229-263.         \u9ad8\u6893\u8317\uff0c\u5f90\u60e0\u7dbf. \u65b0\u8f14\u52a9\u6cbb\u7642\u8207\u8f49\u5316\u6cbb\u7642\u2014\u2014\u63a2\u7d22\u9069\u5408\u4e2d\u570b\u80c3\u764c\u60a3\u8005\u7684\u570d\u624b\u8853\u671f\u6cbb\u7642\u6a21\u5f0f. \u4e2d\u83ef\u91ab\u5b78\u4fe1\u606f\u5c0e\u5831\uff0c2021, 36(3): 17-17.         Issafras H, et al. Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy. PLoS One. 2021;16(12):e0257972.         Hui E, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355(6332):1428-1433.         Patsoukis N, et al. Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020;3(1):128.         Fenwick C, et al. 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Pharmaceuticals (Basel). 2023;16(7):993.                 \u00a0 \u95dc\u65bc\u5fa9\u5b8f\u6f22\u9716 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ASTRUM-006\u662f\u4e00\u9805\u91dd\u5c0d\u65e9\u671f\u80c3\u764c\u60a3\u8005\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u6f22\u65af\u72c0\u00ae\u806f\u5408\u5316\u7642\u5c0d\u6bd4\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u65b0\u8f14\u52a9\/\u55ae\u85e5\u8f14\u52a9\u6cbb\u7642\u65e9\u671f\u80c3\u764c\u60a3\u8005\u7684\u81e8\u5e8a\u6709\u6548\u6027\u53ca\u5b89\u5168\u6027\u3002\u6839\u64da\u7368\u7acb\u6578\u64da\u76e3\u5bdf\u59d4\u54e1\u6703\uff08Independent Data Monitoring Committee, IDMC\uff09\u7684\u671f\u4e2d\u5206\u6790\u7d50\u679c\u986f\u793a\uff1a\u8a72\u7814\u7a76\u9054\u5230\u9810\u8a2d\u7684\u512a\u6548\u6027\u6a19\u6e96\u3002\u8207\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u76f8\u6bd4\uff0c\u6f22\u65af\u72c0\u00ae\u806f\u5408\u5316\u7642\u986f\u8457\u6539\u5584EFS\uff0c\u75c5\u7406\u5b8c\u5168\u7de9\u89e3\uff08pCR\uff09\u7387\u662f\u5c0d\u7167\u7d443\u500d\u591a\uff0c\u60a3\u8005\u5fa9\u767c\u98a8\u96aa\u660e\u986f\u964d\u4f4e\u3002\u540c\u6642\uff0c\u8a72\u6cbb\u7642\u65b9\u6848\u5b89\u5168\u6027\u826f\u597d\uff0c\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u57fa\u65bc\u9019\u4e00\u7a4d\u6975\u7d50\u679c\uff0c\u5efa\u8b70\u63d0\u524d\u7533\u5831\u4e0a\u5e02\u3002 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\u672a\u4f86\uff0c\u5fa9\u5b8f\u6f22\u9716\u5c07\u4f9d\u6258\u7522\u54c1\u7ba1\u7dda\u7684\u591a\u5c64\u6b21\u5275\u65b0\u7642\u6cd5\u77e9\u9663\uff0c\u4ee5\u53ca\u8c50\u5bcc\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6301\u7e8c\u6df1\u5316\u5728\u6d88\u5316\u9053\u816b\u7624\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u81f4\u529b\u65bc\u5c07\u66f4\u591a\u512a\u8cea\u6cbb\u7642\u65b9\u6848\u63a8\u5411\u5168\u7403\uff0c\u60e0\u53ca\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u3002                  \u3010\u53c3\u8003\u6587\u737b\u3011         Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2024;74(3):229-263.         \u9ad8\u6893\u8317\uff0c\u5f90\u60e0\u7dbf. \u65b0\u8f14\u52a9\u6cbb\u7642\u8207\u8f49\u5316\u6cbb\u7642\u2014\u2014\u63a2\u7d22\u9069\u5408\u4e2d\u570b\u80c3\u764c\u60a3\u8005\u7684\u570d\u624b\u8853\u671f\u6cbb\u7642\u6a21\u5f0f. \u4e2d\u83ef\u91ab\u5b78\u4fe1\u606f\u5c0e\u5831\uff0c2021, 36(3): 17-17.         Issafras H, et al. Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy. PLoS One. 2021;16(12):e0257972.         Hui E, et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science. 2017;355(6332):1428-1433.         Patsoukis N, et al. Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020;3(1):128.         Fenwick C, et al. 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Pharmaceuticals (Basel). 2023;16(7):993.                 \u00a0 \u95dc\u65bc\u5fa9\u5b8f\u6f22\u9716 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\u672a\u4f86\uff0c\u5fa9\u5b8f\u6f22\u9716\u5c07\u4f9d\u6258\u7522\u54c1\u7ba1\u7dda\u7684\u591a\u5c64\u6b21\u5275\u65b0\u7642\u6cd5\u77e9\u9663\uff0c\u4ee5\u53ca\u8c50\u5bcc\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6301\u7e8c\u6df1\u5316\u5728\u6d88\u5316\u9053\u816b\u7624\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u81f4\u529b\u65bc\u5c07\u66f4\u591a\u512a\u8cea\u6cbb\u7642\u65b9\u6848\u63a8\u5411\u5168\u7403\uff0c\u60e0\u53ca\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u3002                  \u3010\u53c3\u8003\u6587\u737b\u3011         Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 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Pharmaceuticals (Basel). 2023;16(7):993.                 \u00a0 \u95dc\u65bc\u5fa9\u5b8f\u6f22\u9716 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\u672a\u4f86\uff0c\u5fa9\u5b8f\u6f22\u9716\u5c07\u4f9d\u6258\u7522\u54c1\u7ba1\u7dda\u7684\u591a\u5c64\u6b21\u5275\u65b0\u7642\u6cd5\u77e9\u9663\uff0c\u4ee5\u53ca\u8c50\u5bcc\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6301\u7e8c\u6df1\u5316\u5728\u6d88\u5316\u9053\u816b\u7624\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u81f4\u529b\u65bc\u5c07\u66f4\u591a\u512a\u8cea\u6cbb\u7642\u65b9\u6848\u63a8\u5411\u5168\u7403\uff0c\u60e0\u53ca\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u3002                  \u3010\u53c3\u8003\u6587\u737b\u3011         Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 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\u672a\u4f86\uff0c\u5fa9\u5b8f\u6f22\u9716\u5c07\u4f9d\u6258\u7522\u54c1\u7ba1\u7dda\u7684\u591a\u5c64\u6b21\u5275\u65b0\u7642\u6cd5\u77e9\u9663\uff0c\u4ee5\u53ca\u8c50\u5bcc\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\uff0c\u6301\u7e8c\u6df1\u5316\u5728\u6d88\u5316\u9053\u816b\u7624\u9818\u57df\u7684\u9818\u5148\u512a\u52e2\uff0c\u81f4\u529b\u65bc\u5c07\u66f4\u591a\u512a\u8cea\u6cbb\u7642\u65b9\u6848\u63a8\u5411\u5168\u7403\uff0c\u60e0\u53ca\u66f4\u5ee3\u6cdb\u7684\u60a3\u8005\u7fa4\u9ad4\u3002 \u3010\u53c3\u8003\u6587\u737b\u3011 Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. 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