{"id":370433,"date":"2025-10-09T12:39:00","date_gmt":"2025-10-09T04:39:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=370433"},"modified":"2025-10-09T12:39:00","modified_gmt":"2025-10-09T04:39:00","slug":"%e8%89%be%e6%9b%b2%e8%8e%ab%e5%be%b7%e4%ba%9e%e6%b4%b2%e5%a4%9a%e4%b8%ad%e5%bf%83%e2%85%b2%e6%9c%9f%e8%87%a8%e5%ba%8aenlight-uc%e7%a0%94%e7%a9%b6%ef%bc%88es101002%ef%bc%89%e7%b5%90%e6%9e%9c%e6%a6%ae","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=370433","title":{"rendered":"\u827e\u66f2\u83ab\u5fb7\u4e9e\u6d32\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u7d50\u679c\u69ae\u767b\u300a\u67f3\u8449\u5200\u300b\u5b50\u520a\u300aThe Lancet Gastroenterology &amp; Hepatology\u300b"},"content":{"rendered":"<div>\n<ul type=\"disc\">\n<li>\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b\u8fd1\u65e5\u767c\u8868\u4e86\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u60a3\u8005\u4e2d\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u6210\u679c\uff0c\u6a19\u8a8c\u8457\u9019\u6b3e\u65b0\u4e00\u4ee3\u9ad8\u9078\u64c7\u6027S1P\u53d7\u9ad4\u8abf\u7bc0\u5291\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u9802\u7d1a\u5b78\u8853\u671f\u520a\u8a8d\u53ef\u3002<\/li>\n<li>ENLIGHT UC\u7814\u7a76\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08\u7d0d\u5165340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u3002<\/li>\n<li>\u76ee\u524d\uff0c\u80fd\u9054\u5230\u9ecf\u819c\u7652\u5408\u6cbb\u7642\u76ee\u6a19\u7684\u60a3\u8005\u50c5\u4f54\u7d0424%\u3002ENLIGHT UC\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u764252\u5468\u9ecf\u819c\u7652\u5408\u7387\u9ad8\u905451.9%\uff0c\u9ecf\u819c\u5b8c\u5168\u6b63\u5e38\u5316\u9ad8\u905445.5%\u3002<\/li>\n<li>\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u5728\u5feb\u901f\u8d77\u6548\u3001\u5be6\u73fe\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6df1\u5ea6\u9ecf\u819c\u7652\u5408\u65b9\u9762\u5177\u6709\u986f\u8457\u81e8\u5e8a\u512a\u52e2\uff0c\u70ba\u5305\u62ec\u4e2d\u570b\u60a3\u8005\u5728\u5167\u7684\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u63d0\u4f9b\u5805\u5be6\u7684\u81e8\u5e8a\u8b49\u64da\u652f\u6301\u3002\u572812\u5468\u8a98\u5c0e\u671f\u53ca40\u5468\u7dad\u6301\u671f\u6cbb\u7642\u4e2d\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d44\u5728\u6240\u6709\u4e3b\u8981\u548c\u6b21\u8981\u7642\u6548\u7d42\u9ede\u4e0a\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u8207\u81e8\u5e8a\u610f\u7fa9\u3002\u540c\u6642\uff0c\u7dad\u6301\u671f\u6cbb\u7642\u986f\u793a\u4e86\u827e\u66f2\u83ab\u5fb7\u826f\u597d\u7684\u5b89\u5168\u6027\u3002<\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2025\u5e7410\u67089\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212;\u00a0\u96f2\u9802\u65b0\u8000\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u7684\u85e5\u7269\u827e\u66f2\u83ab\u5fb7\uff08VELSIPITY<sup>\u00ae<\/sup>, etrasimod\uff09\u7684\u4e9e\u6d32\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u7d50\u679c\u767c\u8868\u5728\u570b\u969b\u9802\u7d1a\u671f\u520a\u67f3\u8449\u5200\u5b50\u520a\u300a<i>The Lancet Gastroenterology &amp; Hepatology<\/i>\u300b(\u4e2d\u6587\u540d\u7a31\uff1a\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b)\u3002\u7814\u7a76\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u5728\u5feb\u901f\u8d77\u6548\u3001\u5be6\u73fe\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6df1\u5ea6\u9ecf\u819c\u7652\u5408\u65b9\u9762\u5177\u6709\u986f\u8457\u81e8\u5e8a\u512a\u52e2\uff0c\u70ba\u5305\u62ec\u4e2d\u570b\u60a3\u8005\u5728\u5167\u7684\u4e9e\u6d32UC\u60a3\u8005\u63d0\u4f9b\u5805\u5be6\u7684\u81e8\u5e8a\u8b49\u64da\u652f\u6301\u3002<\/p>\n<p>\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b\u662f\u5168\u7403\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u9818\u57df\u6700\u5177\u5f71\u97ff\u529b\u7684\u5b78\u8853\u671f\u520a\u4e4b\u4e00<sup>[1]<\/sup>\u3002ENLIGHT UC\u7814\u7a76\u6210\u679c\u7684\u767c\u8868\u6a19\u8a8c\u8457\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u81e8\u5e8a\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u5b78\u8853\u754c\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u5176\u5728\u81e8\u5e8a\u4e0a\u7684\u79d1\u5b78\u4f9d\u64da\u548c\u6cbb\u7642\u50f9\u503c\u3002<\/p>\n<p>ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u662f\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u53f0\u7063\u548c\u97d3\u570b\uff09\u958b\u5c55\u7684\u827e\u66f2\u83ab\u5fb7\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167III\u671f\u7814\u7a76\uff0c\u4ea6\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6UC\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027UC\u60a3\u8005\u9032\u5165\u8a98\u5c0e\u671f\uff0c\u4e14\u4ee52:1 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\u96a8\u6a5f\u5206\u7d44\u63a5\u53d7\u70ba\u671f40\u5468\u7684\u6bcf\u65e5\u4e00\u6b21\u827e\u66f2\u83ab\u5fb7\u6216\u5b89\u6170\u5291\u7684\u6cbb\u7642\u3002<\/p>\n<p>\u7814\u7a76\u7684\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u5206\u5225\u70ba\u60a3\u8005\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\u548c\u7dad\u6301\u671f\u7b2c40\u5468\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\u7684\u6bd4\u4f8b\u3002\u7814\u7a76\u7684\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u5247\u70ba\u60a3\u8005\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\u548c\u7dad\u6301\u671f\u7b2c40\u5468\u9054\u5230\u5167\u93e1\u6539\u5584\u548c\u81e8\u5e8a\u61c9\u7b54\u7684\u6bd4\u4f8b\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u572812\u5468\u8a98\u5c0e\u671f\u53ca40\u5468\u7dad\u6301\u671f\u6cbb\u7642\u4e2d\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d44\u5728\u6240\u6709\u4e3b\u8981\u548c\u6b21\u8981\u7642\u6548\u7d42\u9ede\u4e0a\u5747\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u8207\u81e8\u5e8a\u610f\u7fa9\uff1a<\/p>\n<p><b>\u4e3b\u8981\u7642\u6548\u7d42\u9ede\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670957\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768425.0%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba6\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76845.4%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c20.4%\uff0c95% CI 13.4\u201327.4\uff0cp&lt;0.0001\u3002<\/li>\n<li>\u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670937\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768448.1%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba10\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768412.5%\uff09\uff1b\u8abf\u6574\u5dee\u503c35.9%\uff0c95% CI 22.5\u201349.2\uff0cp&lt;0.0001\u3002<\/li>\n<\/ul>\n<p><b>\u6b21\u8981\u7642\u6548\u7d42\u9ede\uff1a<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba85\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768437.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba11\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76849.8%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c28.6%\uff0c95% CI 20.5\u201336.7\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba133\u4f8b\uff0858.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba31\u4f8b\uff0827.7%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c32.0%\uff0c95% CI 21.8\u201342.2\uff0cp&lt;0.0001\u3002<\/li>\n<li>\u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba47\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768461.0%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba12\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768415.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c46.6%\uff0c95% CI 33.2\u201360.1\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba61\u4f8b\uff0879.2%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba28\u4f8b\uff0835.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c45.6%\uff0c95% CI 31.9\u201359.3\uff0cp&lt;0.0001\u3002\u5176\u4ed6\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\u7684\u6b21\u8981\u7d42\u9ede\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p&lt;0.0001\uff09\u7684\u6539\u5584\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 [\u6392\u9664\u6613\u8106] \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.8%\uff08p\uff1c0.0001\uff09\u3002\u540c\u6642\uff0c\u7dad\u6301\u671f\u6cbb\u7642\u986f\u793a\u4e86\u827e\u66f2\u83ab\u5fb7\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5b89\u5168\u6027\u6578\u64da\u8207\u5df2\u77e5\u7279\u5fb5\u4e00\u81f4\uff0c\u6c92\u6709\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/li>\n<\/ul>\n<p><b>\u827e\u66f2\u83ab\u5fb7\u4e9e\u592a\u81e8\u5e8a\u8a66\u9a57\u727d\u982d\u7814\u7a76\u8005\u3001\u4e16\u754c\u80c3\u8178\u75c5\u5b78\u6703\u53f8\u5eab\u3001\u4e9e\u592a\u6d88\u5316\u75c5\u5b78\u6703\u526f\u4e3b\u5e2d\u3001\u4e2d\u83ef\u91ab\u5b78\u6703\u7b2c\u5341\u5c46\u6d88\u5316\u75c5\u5b78\u5206\u6703\u526f\u4e3b\u4efb\u59d4\u54e1\u3001\u4e2d\u570b\u4eba\u6c11\u89e3\u653e\u8ecd\u7b2c\u56db\u8ecd\u91ab\u5927\u5b78\u9644\u5c6c\u897f\u4eac\u91ab\u9662\u5433\u958b\u6625\u6559\u6388<\/b>\u8868\u793a\uff1a\u300c\u570b\u969b\u6b0a\u5a01\u671f\u520a<i>\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b<\/i>\u8fd1\u65e5\u767c\u8868\u4e86\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4e2d\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u6210\u679c\uff0c\u6a19\u8a8c\u8457\u9019\u6b3e\u65b0\u4e00\u4ee3\u9ad8\u9078\u64c7\u6027S1P\u53d7\u9ad4\u8abf\u7bc0\u5291\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u9802\u7d1a\u5b78\u8853\u671f\u520a\u8a8d\u53ef\u3002\u00a0<\/p>\n<p>\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u60a3\u75c5\u7387\u9ad8\uff0c\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u4e14\u53cd\u8986\u767c\u4f5c\uff0c\u9577\u671f\u9810\u5f8c\u5dee\u3002\u7814\u7a76\u986f\u793a\uff0c96%\u60a3\u8005\u7684\u793e\u6703\u6d3b\u52d5\u53d7\u5f71\u97ff<sup>[2]<\/sup>\uff0c10\u5e74\u75be\u75c5\u9032\u5c55\u7387\u9ad8\u905467.5%<sup>[3]<\/sup>\uff0c17.1%\u60a3\u8005\u5728\u78ba\u8a3a\u5f8c20\u5e74\u5167\u767c\u5c55\u70ba\u7d50\u76f4\u8178\u764c<sup>[4]<\/sup>\uff0c\u9019\u4e5f\u5c0d\u500b\u4eba\u548c\u91ab\u7642\u7cfb\u7d71\u5e36\u4f86\u6c89\u91cd\u8ca0\u64d4\u3002\u56e0\u6b64\uff0c\u5be6\u73fe\u9ecf\u819c\u7652\u5408\u6709\u52a9\u65bc\u66f4\u6709\u6548\u5730\u63a7\u5236\u6f70\u760d\u6027\u7d50\u8178\u708e\u75c7\u72c0\uff0c\u964d\u4f4e\u5fa9\u767c\u7387\u4e26\u6539\u5584\u751f\u6d3b\u8cea\u91cf\uff0c\u4f46\u76ee\u524d\u80fd\u9054\u5230\u9ecf\u819c\u7652\u5408\u6cbb\u7642\u76ee\u6a19\u7684\u60a3\u8005\u50c5\u4f54\u7d0424%<sup>[5]<\/sup>\u3002<\/p>\n<p>\u5728\u6b64\u4e4b\u524d\uff0c\u4e9e\u6d32\u5730\u5340\u5728\u4e2d\u91cd\u5ea6UC\u9818\u57df\u5c1a\u7f3a\u4e4f\u9ad8\u8cea\u91cf\u81e8\u5e8a\u6578\u64da\u3002 ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u6578\u64da\u586b\u88dc\u4e86\u4e9e\u6d32\u6f70\u760d\u6027\u7d50\u8178\u708e\u81e8\u5e8a\u6578\u64da\u7a7a\u767d\uff0c\u9a57\u8b49\u4e86\u827e\u66f2\u83ab\u5fb7\u5c0d\u5305\u62ec\u4e2d\u570b\u60a3\u8005\u5728\u5167\u7684\u4e9e\u6d32\u4eba\u7fa4\u5177\u6709\u826f\u597d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u5728\u591a\u500b\u7d42\u9ede\u65b9\u9762\u90fd\u986f\u793a\u51fa\u5f37\u5927\u7684\u7642\u6548\u3002ENLIGHT UC\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u764252\u5468\u9ecf\u819c\u7652\u5408\u7387\u9ad8\u905451.9%\uff0c\u9ecf\u819c\u5b8c\u5168\u6b63\u5e38\u5316\u9ad8\u905445.5%\uff0c\u6709\u671b\u6e1b\u5c11\u4f75\u767c\u75c7\u3001\u63d0\u5347\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u3002\u6211\u5011\u671f\u5f85\u827e\u66f2\u83ab\u5fb7\u70ba\u66f4\u591a\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u6cbb\u7642\u65b0\u9078\u64c7\u3002\u300d<\/p>\n<p><b>\u96f2\u9802\u65b0\u8000\u9996\u5e2d\u57f7\u884c\u5b98\u7f85\u6c38\u6176<\/b>\u8868\u793a\uff1a\u300c\u827e\u66f2\u83ab\u5fb7ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u6210\u679c\u767c\u8868\u65bc\u67f3\u8449\u5200\u5b50\u520a<i>\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b<\/i>\uff0c\u5145\u5206\u5c55\u73fe\u51fa\u5176\u81e8\u5e8a\u50f9\u503c\u548c\u5b78\u8853\u5f71\u97ff\u529b\uff0c\u9032\u4e00\u6b65\u78ba\u7acb\u827e\u66f2\u83ab\u5fb7\u4f5c\u70ba\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u4e00\u7dda\u7642\u6cd5\u7684\u5730\u4f4d\u3002<\/p>\n<p>\u4f5c\u70ba\u65b0\u4e00\u4ee3\u9ad8\u9078\u64c7\u6027S1P\u53d7\u9ad4\u8abf\u7bc0\u5291\uff0c\u827e\u66f2\u83ab\u5fb7\u5177\u5099\u6700\u4f73\u85e5\u7269\uff08best-in-disease\uff09\u6f5b\u8cea\uff0c\u4ee5\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7684\u6cbb\u7642\u65b9\u6848\u5be6\u73fe\u5feb\u901f\u8d77\u6548\u548c\u5f37\u6548\u6df1\u5ea6\u9ecf\u819c\u7652\u5408\uff0c\u4e26\u517c\u9867\u826f\u597d\u5b89\u5168\u6027\u3002<\/p>\n<p>\u96a8\u8457\u4e9e\u6d32\u5730\u5340\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4eba\u6578\u6301\u7e8c\u6500\u5347\uff0c\u50c5\u4e2d\u570b\u60a3\u8005\u6578\u91cf\u9810\u8a08\u5c07\u5f9e2024\u5e74\u7684\u7d0480\u842c\u589e\u81f32031\u5e74\u7684\u8fd1150\u842c\uff0c\u81e8\u5e8a\u4e9f\u9700\u66f4\u6709\u6548\u5b89\u5168\u7684\u5275\u65b0\u7642\u6cd5\u3002\u6b64\u6b21\u7814\u7a76\u6210\u679c\u7684\u767c\u8868\u70ba\u5168\u7403\u6cbb\u7642\u7b56\u7565\u63d0\u4f9b\u4e86\u5805\u5be6\u79d1\u5b78\u4f9d\u64da\uff0c\u800c\u827e\u66f2\u83ab\u5fb7\u6b64\u524d\u5df2\u7372\u5f97\u591a\u500b\u570b\u969b\u6b0a\u5a01\u6307\u5357\u7684\u5f37\u70c8\u63a8\u85a6\u3002<\/p>\n<p>\u6211\u5011\u76f8\u4fe1\uff0c\u827e\u66f2\u83ab\u5fb7\u6709\u671b\u6210\u70ba\u96f2\u9802\u65b0\u8000\u7684\u4e0b\u4e00\u500b\u5546\u696d\u5316\u5927\u55ae\u54c1\uff0c\u6210\u70ba\u516c\u53f8\u672a\u4f86\u7684\u91cd\u8981\u652f\u67f1\u3002\u70ba\u4fdd\u969c\u4e2d\u570b\u53ca\u4e9e\u6d32\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u516c\u53f8\u5df2\u65bc\u4eca\u5e743\u6708\u555f\u52d5\u827e\u66f2\u83ab\u5fb7\u672c\u5730\u5316\u751f\u7522\uff0c\u4e26\u52a0\u901f\u63a8\u9032\u5176\u4e0a\u5e02\u9032\u7a0b\uff0c\u76e1\u5feb\u8b93\u66f4\u591a\u60a3\u8005\u53d7\u76ca\u3002\u300d<\/p>\n<p>\u4f5c\u70ba\u96f2\u9802\u65b0\u8000\u5728\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9818\u57df\u4f48\u5c40\u7684\u6838\u5fc3\u5275\u65b0\u7522\u54c1\uff0c\u827e\u66f2\u83ab\u5fb7\uff08\u7dad\u9069\u5e73<sup>\u00ae<\/sup>\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u65bc2024\u5e7412\u6708\u7372\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u53d7\u7406\uff0c\u9810\u8a08\u5c07\u65bc2026\u5e74\u4e0a\u534a\u5e74\u7372\u6279\u3002\u827e\u66f2\u83ab\u5fb7\u5df2\u88ab\u7d0d\u5165\u7cb5\u6e2f\u6fb3\u5927\u7063\u5340\u5167\u57309\u5e02\u81e8\u5e8a\u6025\u9700\u9032\u53e3\u6e2f\u6fb3\u85e5\u54c1\u91ab\u7642\u5668\u68b0\u76ee\u9304\uff082024\u5e74\uff09\uff0c\u5728\u5927\u7063\u5340\u5148\u884c\u4f7f\u7528\u3002\u827e\u66f2\u83ab\u5fb7\u5df2\u5728\u65b0\u52a0\u5761\u3001\u4e2d\u570b\u6fb3\u9580\u548c\u4e2d\u570b\u9999\u6e2f\u7372\u6279\uff0c\u5176\u65b0\u85e5\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\u4e5f\u5df2\u5728\u97d3\u570b\u548c\u4e2d\u570b\u53f0\u7063\u5730\u5340\u7372\u6b63\u5f0f\u53d7\u7406\u3002<\/p>\n<p>\u827e\u66f2\u83ab\u5fb7\u5df2\u88ab\u7d0d\u51652024\u5e74\u7f8e\u570b\u80c3\u8178\u75c5\u5b78\u5354\u6703\uff08AGA\uff09\u81e8\u5e8a\u5be6\u8e10\u6307\u5357,\u00a0\u63a8\u85a6\u4f5c\u70ba\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u4e00\u7dda\u6cbb\u7642\u3002\u4eca\u5e746\u6708\uff0c\u827e\u66f2\u83ab\u5fb7\u88ab\u7d0d\u5165\u300a2025\u00a0ACG\u00a0\u81e8\u5e8a\u6307\u5357\uff1a\u6210\u4eba\u6f70\u760d\u6027\u7d50\u8178\u708e\u300b\uff0c\u88ab\u5f37\u70c8\u63a8\u85a6\u7528\u65bc\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u8a98\u5c0e\u548c\u7dad\u6301\u6cbb\u7642\uff0c\u6a19\u8a8c\u8457\u5176\u81e8\u5e8a\u50f9\u503c\u7372\u5f97\u4e86\u570b\u969b\u6b0a\u5a01\u5b78\u8853\u6a5f\u69cb\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u4e5f\u70ba\u81e8\u5e8a\u5be6\u8e10\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u9032\u4e00\u6b65\u5370\u8b49\u4e86\u5176\u5168\u7403\u5c08\u696d\u5171\u8b58\u4e0b\u7684\u81e8\u5e8a\u50f9\u503c\u3002<\/p>\n<p>[1] 2024\u5e74\u300a\u671f\u520a\u5f15\u8b49\u5831\u544a\u300b\uff08Clarivate 2025\uff09\u4e2d\u70ba38.6\uff0cCiteScore\u6307\u6578\u503c\u70ba51.1\u3002<br \/>[2] \u5c91\u4fca\u5a01,\u7b49.\u4e2d\u5916\u91ab\u5b78\u7814\u7a76,2021,19(16):182-184.<br \/>[3] Fumery M, et al. Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3<br \/>[4] Eaden JA, Abrams KR, Mayberry JF. Gut. 2001;48(4):526-535. doi:10.1136\/gut.48.4.526<br \/>[5] \u6f70\u760d\u6027\u7d50\u8178\u708e\u8a8d\u8b58\u65b0\u8996\u89d2\uff0c2023<\/p>\n<p><b>\u95dc\u65bc\u827e\u66f2\u83ab\u5fb7\uff08VELSIPITY<sup>\u00ae<\/sup>, 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2024\u5e74\u300a\u671f\u520a\u5f15\u8b49\u5831\u544a\u300b\uff08Clarivate 2025\uff09\u4e2d\u70ba38.6\uff0cCiteScore\u6307\u6578\u503c\u70ba51.1\u3002 \u5c91\u4fca\u5a01,\u7b49.\u4e2d\u5916\u91ab\u5b78\u7814\u7a76,2021,19(16):182-184. Fumery M, et al. Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3 Eaden JA, Abrams KR, Mayberry JF. 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--\u00a0\u96f2\u9802\u65b0\u8000\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u7684\u85e5\u7269\u827e\u66f2\u83ab\u5fb7\uff08VELSIPITY\u00ae, etrasimod\uff09\u7684\u4e9e\u6d32\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u7d50\u679c\u767c\u8868\u5728\u570b\u969b\u9802\u7d1a\u671f\u520a\u67f3\u8449\u5200\u5b50\u520a\u300aThe Lancet Gastroenterology &amp; Hepatology\u300b(\u4e2d\u6587\u540d\u7a31\uff1a\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b)\u3002\u7814\u7a76\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u5728\u5feb\u901f\u8d77\u6548\u3001\u5be6\u73fe\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6df1\u5ea6\u9ecf\u819c\u7652\u5408\u65b9\u9762\u5177\u6709\u986f\u8457\u81e8\u5e8a\u512a\u52e2\uff0c\u70ba\u5305\u62ec\u4e2d\u570b\u60a3\u8005\u5728\u5167\u7684\u4e9e\u6d32UC\u60a3\u8005\u63d0\u4f9b\u5805\u5be6\u7684\u81e8\u5e8a\u8b49\u64da\u652f\u6301\u3002 \u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b\u662f\u5168\u7403\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u9818\u57df\u6700\u5177\u5f71\u97ff\u529b\u7684\u5b78\u8853\u671f\u520a\u4e4b\u4e00\u3002ENLIGHT UC\u7814\u7a76\u6210\u679c\u7684\u767c\u8868\u6a19\u8a8c\u8457\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u81e8\u5e8a\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u5b78\u8853\u754c\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u5176\u5728\u81e8\u5e8a\u4e0a\u7684\u79d1\u5b78\u4f9d\u64da\u548c\u6cbb\u7642\u50f9\u503c\u3002 ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u662f\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u53f0\u7063\u548c\u97d3\u570b\uff09\u958b\u5c55\u7684\u827e\u66f2\u83ab\u5fb7\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167III\u671f\u7814\u7a76\uff0c\u4ea6\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6UC\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027UC\u60a3\u8005\u9032\u5165\u8a98\u5c0e\u671f\uff0c\u4e14\u4ee52:1 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\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670957\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768425.0%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba6\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76845.4%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c20.4%\uff0c95% CI 13.4\u201327.4\uff0cp&lt;0.0001\u3002  \u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670937\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768448.1%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba10\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768412.5%\uff09\uff1b\u8abf\u6574\u5dee\u503c35.9%\uff0c95% CI 22.5\u201349.2\uff0cp&lt;0.0001\u3002  \u6b21\u8981\u7642\u6548\u7d42\u9ede\uff1a   \u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba85\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768437.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba11\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76849.8%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c28.6%\uff0c95% CI 20.5\u201336.7\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba133\u4f8b\uff0858.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba31\u4f8b\uff0827.7%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c32.0%\uff0c95% CI 21.8\u201342.2\uff0cp&lt;0.0001\u3002  \u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba47\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768461.0%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba12\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768415.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c46.6%\uff0c95% CI 33.2\u201360.1\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba61\u4f8b\uff0879.2%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba28\u4f8b\uff0835.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c45.6%\uff0c95% CI 31.9\u201359.3\uff0cp&lt;0.0001\u3002\u5176\u4ed6\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\u7684\u6b21\u8981\u7d42\u9ede\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p&lt;0.0001\uff09\u7684\u6539\u5584\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes 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2024\u5e74\u300a\u671f\u520a\u5f15\u8b49\u5831\u544a\u300b\uff08Clarivate 2025\uff09\u4e2d\u70ba38.6\uff0cCiteScore\u6307\u6578\u503c\u70ba51.1\u3002 \u5c91\u4fca\u5a01,\u7b49.\u4e2d\u5916\u91ab\u5b78\u7814\u7a76,2021,19(16):182-184. Fumery M, et al. Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3 Eaden JA, Abrams KR, Mayberry JF. 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UC\u7814\u7a76\uff08ES101002\uff09\u662f\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u53f0\u7063\u548c\u97d3\u570b\uff09\u958b\u5c55\u7684\u827e\u66f2\u83ab\u5fb7\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167III\u671f\u7814\u7a76\uff0c\u4ea6\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6UC\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027UC\u60a3\u8005\u9032\u5165\u8a98\u5c0e\u671f\uff0c\u4e14\u4ee52:1 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\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670957\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768425.0%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba6\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76845.4%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c20.4%\uff0c95% CI 13.4\u201327.4\uff0cp&lt;0.0001\u3002 \u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670937\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768448.1%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba10\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768412.5%\uff09\uff1b\u8abf\u6574\u5dee\u503c35.9%\uff0c95% CI 22.5\u201349.2\uff0cp&lt;0.0001\u3002 \u6b21\u8981\u7642\u6548\u7d42\u9ede\uff1a \u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba85\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768437.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba11\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76849.8%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c28.6%\uff0c95% CI 20.5\u201336.7\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba133\u4f8b\uff0858.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba31\u4f8b\uff0827.7%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c32.0%\uff0c95% CI 21.8\u201342.2\uff0cp&lt;0.0001\u3002 \u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba47\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768461.0%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba12\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768415.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c46.6%\uff0c95% CI 33.2\u201360.1\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba61\u4f8b\uff0879.2%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba28\u4f8b\uff0835.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c45.6%\uff0c95% CI 31.9\u201359.3\uff0cp&lt;0.0001\u3002\u5176\u4ed6\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\u7684\u6b21\u8981\u7d42\u9ede\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p&lt;0.0001\uff09\u7684\u6539\u5584\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.8%\uff08p\uff1c0.0001\uff09\u3002\u540c\u6642\uff0c\u7dad\u6301\u671f\u6cbb\u7642\u986f\u793a\u4e86\u827e\u66f2\u83ab\u5fb7\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5b89\u5168\u6027\u6578\u64da\u8207\u5df2\u77e5\u7279\u5fb5\u4e00\u81f4\uff0c\u6c92\u6709\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u827e\u66f2\u83ab\u5fb7\u4e9e\u592a\u81e8\u5e8a\u8a66\u9a57\u727d\u982d\u7814\u7a76\u8005\u3001\u4e16\u754c\u80c3\u8178\u75c5\u5b78\u6703\u53f8\u5eab\u3001\u4e9e\u592a\u6d88\u5316\u75c5\u5b78\u6703\u526f\u4e3b\u5e2d\u3001\u4e2d\u83ef\u91ab\u5b78\u6703\u7b2c\u5341\u5c46\u6d88\u5316\u75c5\u5b78\u5206\u6703\u526f\u4e3b\u4efb\u59d4\u54e1\u3001\u4e2d\u570b\u4eba\u6c11\u89e3\u653e\u8ecd\u7b2c\u56db\u8ecd\u91ab\u5927\u5b78\u9644\u5c6c\u897f\u4eac\u91ab\u9662\u5433\u958b\u6625\u6559\u6388\u8868\u793a\uff1a\u300c\u570b\u969b\u6b0a\u5a01\u671f\u520a\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b\u8fd1\u65e5\u767c\u8868\u4e86\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u4e2d\u7684\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u6210\u679c\uff0c\u6a19\u8a8c\u8457\u9019\u6b3e\u65b0\u4e00\u4ee3\u9ad8\u9078\u64c7\u6027S1P\u53d7\u9ad4\u8abf\u7bc0\u5291\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u9802\u7d1a\u5b78\u8853\u671f\u520a\u8a8d\u53ef\u3002\u00a0 \u6f70\u760d\u6027\u7d50\u8178\u708e\u7684\u60a3\u75c5\u7387\u9ad8\uff0c\u56b4\u91cd\u5f71\u97ff\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u4e14\u53cd\u8986\u767c\u4f5c\uff0c\u9577\u671f\u9810\u5f8c\u5dee\u3002\u7814\u7a76\u986f\u793a\uff0c96%\u60a3\u8005\u7684\u793e\u6703\u6d3b\u52d5\u53d7\u5f71\u97ff\uff0c10\u5e74\u75be\u75c5\u9032\u5c55\u7387\u9ad8\u905467.5%\uff0c17.1%\u60a3\u8005\u5728\u78ba\u8a3a\u5f8c20\u5e74\u5167\u767c\u5c55\u70ba\u7d50\u76f4\u8178\u764c\uff0c\u9019\u4e5f\u5c0d\u500b\u4eba\u548c\u91ab\u7642\u7cfb\u7d71\u5e36\u4f86\u6c89\u91cd\u8ca0\u64d4\u3002\u56e0\u6b64\uff0c\u5be6\u73fe\u9ecf\u819c\u7652\u5408\u6709\u52a9\u65bc\u66f4\u6709\u6548\u5730\u63a7\u5236\u6f70\u760d\u6027\u7d50\u8178\u708e\u75c7\u72c0\uff0c\u964d\u4f4e\u5fa9\u767c\u7387\u4e26\u6539\u5584\u751f\u6d3b\u8cea\u91cf\uff0c\u4f46\u76ee\u524d\u80fd\u9054\u5230\u9ecf\u819c\u7652\u5408\u6cbb\u7642\u76ee\u6a19\u7684\u60a3\u8005\u50c5\u4f54\u7d0424%\u3002 \u5728\u6b64\u4e4b\u524d\uff0c\u4e9e\u6d32\u5730\u5340\u5728\u4e2d\u91cd\u5ea6UC\u9818\u57df\u5c1a\u7f3a\u4e4f\u9ad8\u8cea\u91cf\u81e8\u5e8a\u6578\u64da\u3002 ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u6578\u64da\u586b\u88dc\u4e86\u4e9e\u6d32\u6f70\u760d\u6027\u7d50\u8178\u708e\u81e8\u5e8a\u6578\u64da\u7a7a\u767d\uff0c\u9a57\u8b49\u4e86\u827e\u66f2\u83ab\u5fb7\u5c0d\u5305\u62ec\u4e2d\u570b\u60a3\u8005\u5728\u5167\u7684\u4e9e\u6d32\u4eba\u7fa4\u5177\u6709\u826f\u597d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\uff0c\u5728\u591a\u500b\u7d42\u9ede\u65b9\u9762\u90fd\u986f\u793a\u51fa\u5f37\u5927\u7684\u7642\u6548\u3002ENLIGHT 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2024\u5e74\u300a\u671f\u520a\u5f15\u8b49\u5831\u544a\u300b\uff08Clarivate 2025\uff09\u4e2d\u70ba38.6\uff0cCiteScore\u6307\u6578\u503c\u70ba51.1\u3002 \u5c91\u4fca\u5a01,\u7b49.\u4e2d\u5916\u91ab\u5b78\u7814\u7a76,2021,19(16):182-184. Fumery M, et al. Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3 Eaden JA, Abrams KR, Mayberry JF. 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2024\u5e74\u300a\u671f\u520a\u5f15\u8b49\u5831\u544a\u300b\uff08Clarivate 2025\uff09\u4e2d\u70ba38.6\uff0cCiteScore\u6307\u6578\u503c\u70ba51.1\u3002 \u5c91\u4fca\u5a01,\u7b49.\u4e2d\u5916\u91ab\u5b78\u7814\u7a76,2021,19(16):182-184. Fumery M, et al. Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3 Eaden JA, Abrams KR, Mayberry JF. 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--\u00a0\u96f2\u9802\u65b0\u8000\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u7814\u767c\u3001\u81e8\u5e8a\u958b\u767c\u3001\u88fd\u9020\u548c\u5546\u696d\u5316\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\u5176\u6cbb\u7642\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027\u6f70\u760d\u6027\u7d50\u8178\u708e\uff08UC\uff09\u7684\u85e5\u7269\u827e\u66f2\u83ab\u5fb7\uff08VELSIPITY\u00ae, etrasimod\uff09\u7684\u4e9e\u6d32\u591a\u4e2d\u5fc3\u2162\u671f\u81e8\u5e8aENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u7d50\u679c\u767c\u8868\u5728\u570b\u969b\u9802\u7d1a\u671f\u520a\u67f3\u8449\u5200\u5b50\u520a\u300aThe Lancet Gastroenterology &amp; Hepatology\u300b(\u4e2d\u6587\u540d\u7a31\uff1a\u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b)\u3002\u7814\u7a76\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u5728\u5feb\u901f\u8d77\u6548\u3001\u5be6\u73fe\u7121\u6fc0\u7d20\u7de9\u89e3\u548c\u6df1\u5ea6\u9ecf\u819c\u7652\u5408\u65b9\u9762\u5177\u6709\u986f\u8457\u81e8\u5e8a\u512a\u52e2\uff0c\u70ba\u5305\u62ec\u4e2d\u570b\u60a3\u8005\u5728\u5167\u7684\u4e9e\u6d32UC\u60a3\u8005\u63d0\u4f9b\u5805\u5be6\u7684\u81e8\u5e8a\u8b49\u64da\u652f\u6301\u3002 \u300a\u67f3\u8449\u5200\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u300b\u662f\u5168\u7403\u80c3\u8178\u75c5\u5b78\u548c\u809d\u75c5\u5b78\u9818\u57df\u6700\u5177\u5f71\u97ff\u529b\u7684\u5b78\u8853\u671f\u520a\u4e4b\u4e00\u3002ENLIGHT UC\u7814\u7a76\u6210\u679c\u7684\u767c\u8868\u6a19\u8a8c\u8457\u827e\u66f2\u83ab\u5fb7\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u81e8\u5e8a\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u5b78\u8853\u754c\u7684\u9ad8\u5ea6\u8a8d\u53ef\uff0c\u9032\u4e00\u6b65\u592f\u5be6\u4e86\u5176\u5728\u81e8\u5e8a\u4e0a\u7684\u79d1\u5b78\u4f9d\u64da\u548c\u6cbb\u7642\u50f9\u503c\u3002 ENLIGHT UC\u7814\u7a76\uff08ES101002\uff09\u662f\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u5730\u5340\uff08\u5305\u62ec\u4e2d\u570b\u5927\u9678\u3001\u4e2d\u570b\u53f0\u7063\u548c\u97d3\u570b\uff09\u958b\u5c55\u7684\u827e\u66f2\u83ab\u5fb7\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167III\u671f\u7814\u7a76\uff0c\u4ea6\u662f\u8fc4\u4eca\u70ba\u6b62\u5b8c\u6210\u7684\u6700\u5927\u898f\u6a21\u7684\u91dd\u5c0d\u4e9e\u6d32\u4e2d\u91cd\u5ea6UC\u60a3\u8005\u7684III\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff0c\u7e3d\u8a08340\u540d\u65e2\u5f80\u5c0d\u81f3\u5c11\u4e00\u7a2e\u6f70\u760d\u6027\u7d50\u8178\u708e\u5e38\u898f\u6cbb\u7642\u3001\u751f\u7269\u5236\u5291\u6216Janus\u6fc0\u9176\u6291\u5236\u5291\u6cbb\u7642\u5931\u6557\u6216\u4e0d\u8010\u53d7\u7684\u4e2d\u91cd\u5ea6\u6d3b\u52d5\u6027UC\u60a3\u8005\u9032\u5165\u8a98\u5c0e\u671f\uff0c\u4e14\u4ee52:1 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\u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670957\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768425.0%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba6\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76845.4%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c20.4%\uff0c95% CI 13.4\u201327.4\uff0cp&lt;0.0001\u3002  \u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u670937\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768448.1%\uff09\u9054\u5230\u81e8\u5e8a\u7de9\u89e3\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba10\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768412.5%\uff09\uff1b\u8abf\u6574\u5dee\u503c35.9%\uff0c95% CI 22.5\u201349.2\uff0cp&lt;0.0001\u3002  \u6b21\u8981\u7642\u6548\u7d42\u9ede\uff1a   \u5728\u8a98\u5c0e\u671f\u7b2c12\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba85\u4f8b\uff08228\u540d\u60a3\u8005\u4e2d\u768437.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba11\u4f8b\uff08112\u540d\u60a3\u8005\u4e2d\u76849.8%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c28.6%\uff0c95% CI 20.5\u201336.7\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba133\u4f8b\uff0858.3%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba31\u4f8b\uff0827.7%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c32.0%\uff0c95% CI 21.8\u201342.2\uff0cp&lt;0.0001\u3002  \u5728\u7dad\u6301\u671f\u7b2c40\u5468\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u5167\u93e1\u6539\u5584\u60a3\u8005\u70ba47\u4f8b\uff0877\u540d\u60a3\u8005\u4e2d\u768461.0%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba12\u4f8b\uff0880\u540d\u60a3\u8005\u4e2d\u768415.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c46.6%\uff0c95% CI 33.2\u201360.1\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba61\u4f8b\uff0879.2%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba28\u4f8b\uff0835.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c45.6%\uff0c95% CI 31.9\u201359.3\uff0cp&lt;0.0001\u3002\u5176\u4ed6\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\u7684\u6b21\u8981\u7d42\u9ede\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p&lt;0.0001\uff09\u7684\u6539\u5584\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes 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2024\u5e74\u300a\u671f\u520a\u5f15\u8b49\u5831\u544a\u300b\uff08Clarivate 2025\uff09\u4e2d\u70ba38.6\uff0cCiteScore\u6307\u6578\u503c\u70ba51.1\u3002 \u5c91\u4fca\u5a01,\u7b49.\u4e2d\u5916\u91ab\u5b78\u7814\u7a76,2021,19(16):182-184. Fumery M, et al. Clin Gastroenterol Hepatol. 2018 Mar;16(3):343-356.e3 Eaden JA, Abrams KR, Mayberry JF. 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33.2\u201360.1\uff0cp&lt;0.0001\u3002\u81e8\u5e8a\u61c9\u7b54\u65b9\u9762\uff0c\u827e\u66f2\u83ab\u5fb7\u7d44\u70ba61\u4f8b\uff0879.2%\uff09\uff0c\u5b89\u6170\u5291\u7d44\u70ba28\u4f8b\uff0835.0%\uff09\uff1b\u8abf\u6574\u5f8c\u5dee\u503c45.6%\uff0c95% CI 31.9\u201359.3\uff0cp&lt;0.0001\u3002\u5176\u4ed6\u5305\u62ec\u9ecf\u819c\u7652\u5408\u3001\u5167\u93e1\u6062\u5fa9\u6b63\u5e38\u7b49\u7684\u6b21\u8981\u7d42\u9ede\u4e5f\u5747\u9054\u5230\u5177\u6709\u986f\u8457\u81e8\u5e8a\u610f\u7fa9\u548c\u7d71\u8a08\u5b78\u610f\u7fa9\uff08p&lt;0.0001\uff09\u7684\u6539\u5584\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u7642\u7d4451.9%\u7684\u60a3\u8005\u9054\u5230\u9ecf\u819c\u7652\u5408\uff08\u5b9a\u7fa9\u70ba\u4e2d\u5fc3\u5316\u95b1\u7247\u5167\u93e1\u8a55\u5206\u22641 \u4e14 Geboes \u6307\u6578\u8a55\u5206\uff1c2.0\uff09\uff0c\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291\u7d44\u76848.8%\uff08p\uff1c0.0001\uff09\u3002\u540c\u6642\uff0c\u7dad\u6301\u671f\u6cbb\u7642\u986f\u793a\u4e86\u827e\u66f2\u83ab\u5fb7\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5b89\u5168\u6027\u6578\u64da\u8207\u5df2\u77e5\u7279\u5fb5\u4e00\u81f4\uff0c\u6c92\u6709\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 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UC\u7814\u7a76\uff08ES101002\uff09\u6210\u679c\uff0c\u6a19\u8a8c\u8457\u9019\u6b3e\u65b0\u4e00\u4ee3\u9ad8\u9078\u64c7\u6027S1P\u53d7\u9ad4\u8abf\u7bc0\u5291\u5728\u4e9e\u6d32\u4eba\u7fa4\u4e2d\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u7372\u5f97\u5168\u7403\u9802\u7d1a\u5b78\u8853\u671f\u520a\u8a8d\u53ef\u3002\u00a0 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UC\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u827e\u66f2\u83ab\u5fb7\u6cbb\u764252\u5468\u9ecf\u819c\u7652\u5408\u7387\u9ad8\u905451.9%\uff0c\u9ecf\u819c\u5b8c\u5168\u6b63\u5e38\u5316\u9ad8\u905445.5%\uff0c\u6709\u671b\u6e1b\u5c11\u4f75\u767c\u75c7\u3001\u63d0\u5347\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u3002\u6211\u5011\u671f\u5f85\u827e\u66f2\u83ab\u5fb7\u70ba\u66f4\u591a\u6f70\u760d\u6027\u7d50\u8178\u708e\u60a3\u8005\u5e36\u4f86\u66f4\u591a\u6cbb\u7642\u65b0\u9078\u64c7\u3002\u300d \u96f2\u9802\u65b0\u8000\u9996\u5e2d\u57f7\u884c\u5b98\u7f85\u6c38\u6176\u8868\u793a\uff1a\u300c\u827e\u66f2\u83ab\u5fb7ENLIGHT 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