{"id":331798,"date":"2025-06-03T11:26:00","date_gmt":"2025-06-03T03:26:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=331798"},"modified":"2025-06-03T11:26:00","modified_gmt":"2025-06-03T03:26:00","slug":"%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5mdm2-p53%e6%8a%91%e5%88%b6%e5%8a%91alrizomadlin%e5%96%ae%e8%97%a5%e5%92%8c%e8%81%af%e5%90%88%e6%b2%bb%e7%99%82%e5%af%a6%e9%ab%94%e7%98%a4%e6%95%b8%e6%93%9a%e7%a9%8d","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=331798","title":{"rendered":"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span> 2025\u5e746\u67083\u65e5<\/span> \/\u7f8e\u901a\u793e\/ —\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002<\/p>\n

\n<\/p><\/div>\n

\u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002<\/p>\n

\u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002<\/p>\n

\u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388<\/b>\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d<\/p>\n

\u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388<\/b>\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a<\/b>\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88’\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42’\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d<\/p>\n

\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n

A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors
<\/b> \u4e00\u9805\u8a55\u4f30\u65b0\u578b<\/b> MDM2<\/b> \u6291\u5236\u5291<\/b> APG-115<\/b> \uff08<\/b> Alrizomadlin<\/b> \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08<\/b> ACC<\/b> \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08<\/b> Pts<\/b> \uff09\u7684<\/b> II<\/b> \u671f\u81e8\u5e8a\u7814\u7a76<\/b> <\/p>\n

    \n
  • \u6458\u8981\u7de8\u865f\uff1a<\/b>6102<\/li>\n
  • \u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u58c1\u5831\u5c55\u793a<\/li>\n
  • \u5206\u6703\u5834\u6a19\u984c\uff1a<\/b>\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09<\/li>\n
  • \u4e3b\u8981\u4f5c\u8005\uff1a<\/b>\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49<\/li>\n
  • \u6838\u5fc3\u8981\u9ede\uff1a
    <\/b>–\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002
    –\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002
    –\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002
    –\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002<\/li>\n<\/ul>\n

    \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/b> <\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002<\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002<\/p>\n

    \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae<\/sup>\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae<\/sup>\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae<\/sup>\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002<\/p>\n

    \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002<\/p>\n

    \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002<\/p>\n

    \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002<\/p>\n

    \u524d\u77bb\u6027\u8072\u660e<\/b> <\/p>\n

    \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002<\/p>\n

    \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002<\/p>\n

    \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    \u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607…<\/p>\n","protected":false},"author":16,"featured_media":331799,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-331798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde 2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002 \u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors \u4e00\u9805\u8a55\u4f30\u65b0\u578b MDM2 \u6291\u5236\u5291 APG-115 \uff08 Alrizomadlin \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08 ACC \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6102 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002 \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=331798\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde 2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002 \u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors \u4e00\u9805\u8a55\u4f30\u65b0\u578b MDM2 \u6291\u5236\u5291 APG-115 \uff08 Alrizomadlin \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08 ACC \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6102 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002 \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=331798\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-03T03:26:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1\" \/>\n\t<meta property=\"og:image:height\" content=\"1\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025\",\"datePublished\":\"2025-06-03T03:26:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798\"},\"wordCount\":193,\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_APAC_Logo-6.jpg\",\"articleSection\":[\"\u7f8e\u901a\u793e\"],\"inLanguage\":\"zh-TW\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798\",\"name\":\"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_APAC_Logo-6.jpg\",\"datePublished\":\"2025-06-03T03:26:00+00:00\",\"description\":\"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde 2025\u5e746\u67083\u65e5 \\\/\u7f8e\u901a\u793e\\\/ --\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002 \u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors \u4e00\u9805\u8a55\u4f30\u65b0\u578b MDM2 \u6291\u5236\u5291 APG-115 \uff08 Alrizomadlin \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08 ACC \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6102 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\\\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\\\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002 \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#breadcrumb\"},\"inLanguage\":\"zh-TW\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#primaryimage\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_APAC_Logo-6.jpg\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/Ascentage_APAC_Logo-6.jpg\",\"width\":400,\"height\":150},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=331798#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9801\",\"item\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"description\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4\",\"publisher\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-TW\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#organization\",\"name\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"contentUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"width\":150,\"height\":150,\"caption\":\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/pingtungnews\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\",\"name\":\"\u7f8e\u901a\u793e\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-TW\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g\",\"caption\":\"\u7f8e\u901a\u793e\"},\"url\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?author=16\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde 2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002 \u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors \u4e00\u9805\u8a55\u4f30\u65b0\u578b MDM2 \u6291\u5236\u5291 APG-115 \uff08 Alrizomadlin \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08 ACC \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6102 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002 \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=331798","og_locale":"zh_TW","og_type":"article","og_title":"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde 2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002 \u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors \u4e00\u9805\u8a55\u4f30\u65b0\u578b MDM2 \u6291\u5236\u5291 APG-115 \uff08 Alrizomadlin \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08 ACC \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6102 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002 \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002","og_url":"https:\/\/pingtungtimes.com.tw\/?p=331798","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2025-06-03T03:26:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":1,"height":1,"type":"image\/jpeg"}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"1 \u5206\u9418"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#article","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=331798"},"author":{"name":"\u7f8e\u901a\u793e","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3"},"headline":"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025","datePublished":"2025-06-03T03:26:00+00:00","mainEntityOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=331798"},"wordCount":193,"publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_APAC_Logo-6.jpg","articleSection":["\u7f8e\u901a\u793e"],"inLanguage":"zh-TW"},{"@type":"WebPage","@id":"https:\/\/pingtungtimes.com.tw\/?p=331798","url":"https:\/\/pingtungtimes.com.tw\/?p=331798","name":"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","isPartOf":{"@id":"https:\/\/pingtungtimes.com.tw\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#primaryimage"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#primaryimage"},"thumbnailUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_APAC_Logo-6.jpg","datePublished":"2025-06-03T03:26:00+00:00","description":"\u7f8e\u570b\u99ac\u88e1\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde 2025\u5e746\u67083\u65e5 \/\u7f8e\u901a\u793e\/ --\u00a0\u2014\u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff08\u7d0d\u65af\u9054\u514b\u4ee3\u78bc\uff1aAAPG\uff1b\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a6855\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7b2c61\u5c46\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5e74\u6703\u4e0a\uff0c\u4ee5\u58c1\u5831\u5c55\u793a\u5f62\u5f0f\u516c\u5e03\u4e86MDM2-p53\u6291\u5236\u5291alrizomadlin\uff08APG-115\uff09\u55ae\u85e5\u6216\u806f\u5408PD-1\u6291\u5236\u5291\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08ACC\uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u6700\u65b0\u9032\u5c55\u3002Alrizomadlin\u70ba\u516c\u53f8\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2e\uff0c\u662f\u9996\u500b\u5728\u4e2d\u570b\u9032\u5165\u81e8\u5e8a\u968e\u6bb5\u7684MDM2-p53\u6291\u5236\u5291\uff0c\u5177\u6709\u5168\u7403First-in-class\u6f5b\u529b\u3002 \u4e00\u5e74\u4e00\u5ea6\u7684ASCO\u5e74\u6703\u662f\u5168\u7403\u816b\u7624\u9818\u57df\u6700\u91cd\u8981\u7684\u3001\u6700\u70ba\u6b0a\u5a01\u7684\u5b78\u8853\u4ea4\u6d41\u76db\u6703\uff0c\u5c07\u5c55\u793a\u7576\u524d\u570b\u969b\u6700\u524d\u6cbf\u7684\u81e8\u5e8a\u816b\u7624\u5b78\u79d1\u7814\u6210\u679c\u548c\u816b\u7624\u6cbb\u7642\u6280\u8853\u3002\u4eca\u5e74\u662f\u4e9e\u76db\u91ab\u85e5\u9023\u7e8c\u7b2c\u516b\u5e74\u4eae\u76f8ASCO\u5e74\u6703\uff0c\u6b64\u6b21\u516c\u53f8\u5171\u6709\u5169\u9805\u7814\u7a76\u5165\u9078\uff0c\u5305\u62ec\u7d30\u80de\u51cb\u4ea1\u7ba1\u7dda\u91cd\u9ede\u54c1\u7a2eBcl-2\u6291\u5236\u5291lisaftoclax\uff08APG-2575\uff09\u548cMDM2-p53\u6291\u5236\u5291alrizomadlin\uff0c\u5176\u4e2dlisaftoclax\u7372\u53e3\u982d\u5831\u544a\uff0calrizomadlin\u7372\u58c1\u5831\u5c55\u793a\u3002 \u6b64\u6b21\u5c55\u793a\u7684alrizomadlin\u6cbb\u7642ACC\u7b49\u5be6\u9ad4\u7624\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff1aalrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u6216\u60e1\u6027\u5916\u5468\u795e\u7d93\u9798\u819c\u7624\uff08MPNST\uff09\u60a3\u8005\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff1b\u540c\u6642alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u8010\u53d7\u6027\u826f\u597d\uff0c\u5728MPNST\u3001\u81bd\u9053\u816b\u7624\uff08BTC\uff09\u548c\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u4e2d\u5747\u986f\u793a\u51fa\u81e8\u5e8a\u6cbb\u7642\u6f5b\u529b\u3002 \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u6559\u6388\u8868\u793a\uff1a\u300cACC\u4f5c\u70ba\u4e00\u7a2e\u7f55\u898b\u816b\u7624\uff0c\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u81e8\u5e8a\u5e38\u7528\u7684\u6297\u8840\u7ba1\u751f\u6210TKI\u6cbb\u7642\u5b58\u5728\u4e00\u5b9a\u7684\u5c40\u9650\u6027\u548c\u5b89\u5168\u6027\u96b1\u60a3\u3002\u672c\u6b21ASCO\u5e74\u6703\u4e0a\u6211\u5011\u5718\u968a\u516c\u5e03\u7684\u9019\u9805\u7814\u7a76\u986f\u793a\uff0calrizomadlin\u6cbb\u7642ACC\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba16.7%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba100%\uff0c\u63d0\u793a\u9776\u5411MDM2-p53\u901a\u8def\u6cbb\u7642ACC\u5177\u6709\u6f5b\u5728\u6297\u816b\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662fACC\u9818\u57df\u7684\u65b0\u7642\u6cd5\u3002\u300d \u8a72\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u6559\u6388\u8868\u793a\uff1a\u300cMPNST\u3001LPS\u7b49\u8089\u7624\u60a3\u8005\u53ef\u4f9b\u9078\u64c7\u7684\u65b9\u6848\u6709\u6548\u9650\u3002\u672c\u7814\u7a76\u4e2d\uff0calrizomadlin\u55ae\u85e5\u6216\u806f\u5408PD-1\u6cbb\u7642MPNST\u5747\u986f\u793a\u51fa\u8f03\u597d\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u7279\u5225\u662f\u806f\u5408\u6cbb\u7642\uff0c\u4f7f2\u4f8bMPNST\u60a3\u8005\u7372\u5f97\u4e86\u9577\u671f\u7de9\u89e3\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\uff1balrizomadlin\u806f\u5408PD-1\u6cbb\u7642LPS\u4e5f\u986f\u793a\u51fa\u4e00\u5b9a\u7684\u7642\u6548\u3002\u9019\u4e9b\u7d50\u679c\u63d0\u793aalrizomadlin\u55ae\u85e5\u6216\u806f\u5408\u6cbb\u7642\u53ef\u80fd\u5728\u8089\u7624\u9818\u57df\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u76ca\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u4f5c\u70ba\u5168\u7403First-in-class\u6f5b\u529b\u54c1\u7a2e\uff0c alrizomadlin\u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6578\u64da\u8868\u660e\u5176\u5728ACC\u53ca\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u6f5b\u529b\uff0c\u4e26\u518d\u4e00\u6b21\u9ad4\u73fe\u4e86\u8a72\u54c1\u7a2e\u8207\u73fe\u6709\u514d\u75ab\u816b\u7624\u85e5\u7269\u4e4b\u9593\u7684\u5354\u540c\u6548\u61c9\uff0c\u6709\u671b\u70ba\u591a\u7a2e\u5be6\u9ad4\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u6cbb\u7642\u9078\u64c7\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u79c9\u6301\u521d\u5fc3\uff0c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u81e8\u5e8a\u958b\u767c\uff0c\u65e9\u65e5\u60e0\u53ca\u5168\u7403\u60a3\u8005\u3002\u300d \u5728\u6b64\u6b21ASCO\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u8a72\u81e8\u5e8a\u7814\u7a76\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a A Phase 2 Study of Novel MDM2 Inhibitor Alrizomadlin (APG-115) With or Without Toripalimab in Patients with Advanced Adenoid Cystic Carcinoma (ACC) or Other Solid Tumors \u4e00\u9805\u8a55\u4f30\u65b0\u578b MDM2 \u6291\u5236\u5291 APG-115 \uff08 Alrizomadlin \uff09\u55ae\u85e5\u6216\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u665a\u671f\u817a\u6a23\u56ca\u6027\u764c\uff08 ACC \uff09\u6216\u5176\u5b83\u5be6\u9ad4\u7624\u60a3\u8005\uff08 Pts \uff09\u7684 II \u671f\u81e8\u5e8a\u7814\u7a76 \u6458\u8981\u7de8\u865f\uff1a6102 \u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u5831\u5c55\u793a \u5206\u6703\u5834\u6a19\u984c\uff1a\u982d\u9838\u764c\uff08Head and Neck Cancer\uff09 \u4e3b\u8981\u4f5c\u8005\uff1a\u4e0a\u6d77\u6771\u65b9\u91ab\u9662\u816b\u7624\u5167\u79d1\u90ed\u66c4\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u674e\u5be7\u535a\u58eb\uff1b\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u9ed1\u8272\u7d20\u7624\u8207\u8089\u7624\u5167\u79d1\u5f35\u661f\u535a\u58eb\uff1b\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u65b9\u7f8e\u7389\u535a\u58eb\uff1b\u4e2d\u570b\u91ab\u5b78\u79d1\u5b78\u9662\u816b\u7624\u91ab\u9662\u738b\u66f8\u822a\u535a\u58eb\u7b49 \u6838\u5fc3\u8981\u9ede\uff1a-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Alrizomadlin\u662f\u4e00\u6b3e\u5728\u7814\u65b0\u578b\u53e3\u670dMDM2\u6291\u5236\u5291\uff0c\u5df2\u5728ACC\u4e2d\u986f\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u521d\u6b65\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u622a\u81f32025\u5e742\u670813\u65e5\uff0c\u7814\u7a76\u5171\u5165\u7d4457\u4f8b\u665a\u671fACC\u3001\u60e1\u6027\u5468\u570d\u795e\u7d93\u9798\u7624\uff08MPNST\uff09\u3001\u665a\u671f\u8102\u80aa\u8089\u7624\uff08LPS\uff09\u548c\u81bd\u7ba1\u764c\uff08BTC\uff09\u7b49\u816b\u7624\u7684\u60a3\u8005\u3002Alrizomadlin\u55ae\u85e5\u5728\u665a\u671fACC\u548cMPNST\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u6297\u816b\u7624\u6d3b\u6027\u3002Alrizomadlin\u806f\u5408\u7279\u745e\u666e\u5229\u55ae\u6297\u5728MPNST\u3001BTC\u548cLPC\u60a3\u8005\u4e2d\u986f\u793a\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u6297\u816b\u7624\u6d3b\u6027\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u55ae\u85e5\u6cbb\u7642\u7d4417\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8bACC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0c DCR\u70ba100%\uff1b5\u4f8bMPNST\u60a3\u8005\u4e2d\uff0c4\u4f8b\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\uff0cDCR\u70ba80%\u300224\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c33.3%\u767c\u751f\u4e86\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff1b\u7814\u7a76\u4e2d\u767c\u751f3\u4f8b\uff0812.5%\uff09\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\u30021\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002-\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u806f\u5408\u6cbb\u7642\u7d4429\u4f8b\u7642\u6548\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c6\u4f8bBTC\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba100%\uff1b6\u4f8bLPS\u60a3\u8005\u7684ORR\u70ba16.7%\uff0cDCR\u70ba66.7%\uff1b\u00a02\u4f8bMPNST\u60a3\u8005\u9054\u5230\u7d93\u78ba\u8a8d\u7684PR\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u986f\u8457\u5ef6\u9577\uff081\u4f8b>60\u5468\uff0c1\u4f8b>96\u5468\uff09\u3002150mg\u5291\u91cf\u7d4427\u4f8b\u5b89\u5168\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c12\u4f8b\uff0844.4%\uff09\u60a3\u8005\u767c\u751f\u4e86\u22653\u7d1aTRAE\uff0c\u00a08\u4f8b\uff0829.6%\uff09\u60a3\u8005\u767c\u751f\u4e86\u8207\u6cbb\u7642\u76f8\u95dc\u7684SAE\uff0c1\u4f8b\u53d7\u8a66\u8005\u56e0TRAE\u7d42\u6b62\u6cbb\u7642\u3002 \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5 \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\uff1b2025\u5e741\u670824\u65e5\uff0c\u516c\u53f8\u5728\u7f8e\u570b\u7d0d\u65af\u9054\u514b\u8b49\u5238\u4ea4\u6613\u6240\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1aAAPG\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u548c\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\u3002 \u516c\u53f8\u6838\u5fc3\u54c1\u7a2e\u8010\u7acb\u514b\u00ae\u662f\u4e2d\u570b\u9996\u500b\u7372\u6279\u4e0a\u5e02\u7684\u7b2c\u4e09\u4ee3BCR-ABL\u6291\u5236\u5291\uff0c\u4e14\u7372\u6279\u9069\u61c9\u75c7\u5747\u88ab\u6210\u529f\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55\u8010\u7acb\u514b\u00ae\u4e00\u9805\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08POLARIS-2\uff09\uff0c\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u63a5\u53d7\u904e\u6cbb\u7642\u7684\u6162\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u6162\u6027\u671f\uff08CML-CP\uff09\u6210\u5e74\u60a3\u8005\u3002\u6b64\u5916\uff0c\u8010\u7acb\u514b\u00ae\u806f\u5408\u6cbb\u7642\u65b0\u8a3a\u65b7\u8cbb\u57ce\u67d3\u8272\u9ad4\u967d\u6027\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u548c\u6cbb\u7642\u7425\u73c0\u9178\u812b\u6c2b\u9176\uff08SDH\uff09\u7f3a\u9677\u578b\u80c3\u8178\u9053\u9593\u8cea\u7624\uff08GIST\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u7814\u7a76\u6b63\u5728\u958b\u5c55\u4e2d\u3002 \u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u54c1\u7a2e\uff0c\u65b0\u578bBcl-2\u9078\u64c7\u6027\u6291\u5236\u5291APG-2575\uff08Lisaftoclax\uff09\u7684\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\uff08NDA\uff09\u5df2\u7372CDE\u53d7\u7406\uff0c\u4e26\u88ab\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u76ee\u524d\uff0c\u4e9e\u76db\u91ab\u85e5\u6b63\u5728\u958b\u5c55APG-2575\uff08Lisaftoclax\uff09\u56db\u9805\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u5206\u5225\u70ba\u7372\u7f8e\u570bFDA\u8a31\u53ef\u7684\u6cbb\u7642\u7d93\u6cbb\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\uff08CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORA\uff09\uff1b\u6cbb\u7642\u521d\u6cbbCLL\/SLL\u60a3\u8005\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4e00\u7dda\u6cbb\u7642\u65b0\u8a3a\u65b7\u8001\u5e74\u6216\u9ad4\u5f31\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u5168\u7403\u6ce8\u518aIII\u671f\u81e8\u5e8a\u7814\u7a76\uff1b\u4ee5\u53ca\u6cbb\u7642\u65b0\u8a3a\u65b7\u4e2d\u9ad8\u5371\u9aa8\u9ad3\u589e\u751f\u7570\u5e38\u7d9c\u5408\u5f81\uff08MDS\uff09\u60a3\u8005\u7684\u6ce8\u518aIII\u671f\u7814\u7a76\u3002 \u622a\u81f3\u76ee\u524d\uff0c\u516c\u53f84\u500b\u5728\u7814\u65b0\u85e5\u5171\u737216\u9805FDA\u548c1\u9805\u6b50\u76df\u5b64\u5152\u85e5\u8cc7\u683c\u8a8d\u5b9a\uff0c2\u9805FDA\u5feb\u901f\u901a\u9053\u8cc7\u683c\u4ee5\u53ca2\u9805FDA\u5152\u7ae5\u7f55\u898b\u75c5\u8cc7\u683c\u8a8d\u8b49\u3002\u6191\u501f\u5f37\u5927\u7684\u7814\u767c\u80fd\u529b\uff0c\u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u5168\u7403\u8303\u570d\u5167\u9032\u884c\u77e5\u8b58\u7522\u6b0a\u5e03\u5c40\uff0c\u4e26\u8207\u6b66\u7530\u3001\u9ed8\u6c99\u6771\u3001\u963f\u65af\u5229\u5eb7\u3001\u8f1d\u745e\u3001\u4fe1\u9054\u7b49\u9818\u5148\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4ee5\u53ca\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\uff08Mayo Clinic\uff09\u3001\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u7cfb\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u5efa\u7acb\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u65b0\u805e\u7a3f\u5305\u542b\u6839\u64da\u7f8e\u570b\u300a1995\u5e74\u79c1\u4eba\u8b49\u5238\u8a34\u8a1f\u6539\u9769\u6cd5\u6848\u300b\uff0c\u4ee5\u53ca\u7d93\u4fee\u8a02\u7684\u300a1933\u5e74\u8b49\u5238\u6cd5\u300b\u7b2c27A\u689d\u548c\u300a1934\u5e74\u8b49\u5238\u4ea4\u6613\u6cd5\u300b\u7b2c21E\u689d\u6240\u754c\u5b9a\u7684\u524d\u77bb\u6027\u9673\u8ff0\u3002\u9664\u6b77\u53f2\u4e8b\u5be6\u9673\u8ff0\u5916\uff0c\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u6240\u6709\u5167\u5bb9\u5747\u53ef\u80fd\u69cb\u6210\u524d\u77bb\u6027\u9673\u8ff0\uff0c\u5305\u62ec\u4e9e\u76db\u91ab\u85e5\u5c0d\u672a\u4f86\u4e8b\u4ef6\u3001\u7d93\u71df\u6210\u679c\u6216\u8ca1\u52d9\u72c0\u6cc1\u6240\u767c\u8868\u7684\u610f\u898b\u3001\u9810\u671f\u3001\u4fe1\u5ff5\u3001\u8a08\u5283\u3001\u76ee\u6a19\u3001\u5047\u8a2d\u6216\u9810\u6e2c\u3002 \u9019\u4e9b\u524d\u77bb\u6027\u9673\u8ff0\u53d7\u5230\u8af8\u591a\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u7684\u5f71\u97ff\uff0c\u5177\u9ad4\u5167\u5bb9\u5df2\u5728\u4e9e\u76db\u91ab\u85e5\u5411\u7f8e\u570b\u8b49\u5238\u4ea4\u6613\u59d4\u54e1\u6703\uff08SEC\uff09\u63d0\u4ea4\u7684\u6587\u4ef6\u4e2d\u8a73\u7d30\u8aaa\u660e\uff0c\u5305\u62ec2025\u5e741\u670821\u65e5\u63d0\u4ea4\u7684\u7d93\u4fee\u8a02\u7684F-1\u8868\u683c\u6ce8\u518a\u8aaa\u660e\u66f8\u548c2025\u5e744\u670816\u65e5\u63d0\u4ea4\u768420-F\u8868\u683c\u4e2d\u7684\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u548c\u300c\u95dc\u65bc\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u884c\u696d\u6578\u64da\u7684\u7279\u5225\u8aaa\u660e\u300d\u7ae0\u7bc0\u30012019\u5e7410\u670816\u65e5\u63d0\u4ea4\u7684\u9996\u6b21\u767c\u884c\u4e0a\u5e02\u62db\u80a1\u66f8\u4e2d\u7684\u300c\u524d\u77bb\u6027\u8072\u660e\u300d\u3001\u300c\u98a8\u96aa\u56e0\u7d20\u300d\u7ae0\u7bc0\uff0c\u4ee5\u53ca\u6211\u5011\u4e0d\u6642\u5411SEC\u6216HKEX\u63d0\u4ea4\u7684\u5176\u4ed6\u6587\u4ef6\u3002\u9019\u4e9b\u56e0\u7d20\u53ef\u80fd\u5c0e\u81f4\u5be6\u969b\u696d\u7e3e\u3001\u904b\u71df\u6c34\u5e73\u3001\u7d93\u71df\u6210\u679c\u6216\u6210\u5c31\u8207\u524d\u77bb\u6027\u9673\u8ff0\u4e2d\u660e\u793a\u6216\u6697\u793a\u7684\u4fe1\u606f\u5b58\u5728\u91cd\u5927\u5dee\u7570\u3002\u672c\u524d\u77bb\u6027\u8072\u660e\u4e2d\u7684\u9673\u8ff0\u4e0d\u69cb\u6210\u516c\u53f8\u7ba1\u7406\u5c64\u7684\u5229\u6f64\u9810\u6e2c\u3002 \u56e0\u6b64\uff0c\u8a72\u7b49\u524d\u77bb\u6027\u9673\u8ff0\u4e0d\u61c9\u88ab\u8996\u70ba\u5c0d\u672a\u4f86\u4e8b\u4ef6\u7684\u9810\u6e2c\u3002\u672c\u65b0\u805e\u7a3f\u4e2d\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u57fa\u65bc\u4e9e\u76db\u91ab\u85e5\u7576\u524d\u5c0d\u672a\u4f86\u767c\u5c55\u53ca\u5176\u6f5b\u5728\u5f71\u97ff\u7684\u9810\u671f\u548c\u5224\u65b7\uff0c\u4e14\u50c5\u4ee3\u8868\u622a\u81f3\u9673\u8ff0\u767c\u8868\u4e4b\u65e5\u7684\u89c0\u9ede\u3002\u7121\u8ad6\u51fa\u73fe\u65b0\u4fe1\u606f\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u4e9e\u76db\u91ab\u85e5\u5747\u7121\u7fa9\u52d9\u66f4\u65b0\u6216\u4fee\u8a02\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u3002","breadcrumb":{"@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#breadcrumb"},"inLanguage":"zh-TW","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pingtungtimes.com.tw\/?p=331798"]}]},{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#primaryimage","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_APAC_Logo-6.jpg","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/Ascentage_APAC_Logo-6.jpg","width":400,"height":150},{"@type":"BreadcrumbList","@id":"https:\/\/pingtungtimes.com.tw\/?p=331798#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9801","item":"https:\/\/pingtungtimes.com.tw\/"},{"@type":"ListItem","position":2,"name":"\u4e9e\u76db\u91ab\u85e5MDM2-p53\u6291\u5236\u5291Alrizomadlin\u55ae\u85e5\u548c\u806f\u5408\u6cbb\u7642\u5be6\u9ad4\u7624\u6578\u64da\u7a4d\u6975|\u76f4\u64caASCO 2025"}]},{"@type":"WebSite","@id":"https:\/\/pingtungtimes.com.tw\/#website","url":"https:\/\/pingtungtimes.com.tw\/","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831PingtungTimes\uff0c\u6700\u95dc\u5fc3\u5728\u5730\u7684\u5a92\u9ad4","publisher":{"@id":"https:\/\/pingtungtimes.com.tw\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pingtungtimes.com.tw\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-TW"},{"@type":"Organization","@id":"https:\/\/pingtungtimes.com.tw\/#organization","name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","url":"https:\/\/pingtungtimes.com.tw\/","logo":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/","url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","contentUrl":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","width":150,"height":150,"caption":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831"},"image":{"@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/pingtungnews"]},{"@type":"Person","@id":"https:\/\/pingtungtimes.com.tw\/#\/schema\/person\/683b937f29ec1537972f6c41e22a2cf3","name":"\u7f8e\u901a\u793e","image":{"@type":"ImageObject","inLanguage":"zh-TW","@id":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/6c21e24ce33ca5d4572e343395adac2bbef44ff7035a74ea2cab2443c7f0a5f3?s=96&d=blank&r=g","caption":"\u7f8e\u901a\u793e"},"url":"https:\/\/pingtungtimes.com.tw\/?author=16"}]}},"_links":{"self":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/331798","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=331798"}],"version-history":[{"count":0,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/331798\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=\/wp\/v2\/media\/331799"}],"wp:attachment":[{"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=331798"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=331798"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pingtungtimes.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=331798"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}