{"id":329065,"date":"2025-05-26T08:00:00","date_gmt":"2025-05-26T00:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=329065"},"modified":"2025-05-26T08:00:00","modified_gmt":"2025-05-26T00:00:00","slug":"%e6%a6%ae%e8%80%80%e7%99%bb%e9%a0%82-%e5%85%a8%e7%90%83%e9%a6%96%e6%ac%be%e7%94%b3%e5%a0%b1%e4%b8%8a%e5%b8%82%e7%9a%84gcg-glp-1%e9%9b%99%e5%8f%97%e9%ab%94%e6%bf%80%e5%8b%95%e6%b8%9b%e9%87%8d","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=329065","title":{"rendered":"\u69ae\u8000\u767b\u9802 | \u5168\u7403\u9996\u6b3e\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u746a\u4ed5\u5ea6\u80bd\u7684\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u5e03"},"content":{"rendered":"<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2025\u5e745\u670826\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\uff08GCG\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u746a\u4ed5\u5ea6\u80bd\uff0c\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\u7d50\u679c\u8fd1\u65e5\u5728\u570b\u969b\u77e5\u540d\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08The New England Journal of Medicine, NEJM\uff09\u5168\u6587\u5728\u7dda\u767c\u8868<span id=\"spanHghlt4bd6\">\u4e26\u7279\u914d\u5c08\u5bb6\u8a55\u8ff0<\/span><span id=\"spanHghlt0cd5\">[<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2411528\" target=\"_blank\" rel=\"nofollow noopener\" style=\"color: #0000FF\">https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2411528<\/a>]<\/span>\u3002\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\u5206\u5225\u70ba\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u6cb3\u5357\u79d1\u6280\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u59dc\u5b8f\u885b\u6559\u6388\uff0c\u53e6\u5916\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9322\u9433\u535a\u58eb\u70ba\u672c\u6587\u5171\u540c\u901a\u8a0a\u4f5c\u8005\u3002<\/p>\n<p><b>\u9019\u662f\u5168\u7403\u9996\u500b\u4e14\u552f\u4e00\u7533\u5831\u4e0a\u5e02\u7684<\/b><b>GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u7684\u81e8\u5e8a\u7814\u7a76\u7b2c\u4e00\u6b21\u767b\u9802\u91ab\u5b78\u6b0a\u5a01\u5b78\u8853\u671f\u520a\uff0c\u5c07\u6539\u5beb\u570b\u5167\u5916\u8d85\u91cd\u548c\u80a5\u80d6\u75be\u75c5\u7684\u81e8\u5e8a\u6cbb\u7642\u548c\u6307\u5357\u3002\u5728\u4e2d\u570b\u4ee3\u8b1d\u548c\u5167\u5206\u6ccc\u75be\u75c5\u9818\u57df\uff0c\u7b2c\u4e00\u6b21\u6709\u5275\u65b0\u85e5\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u5168\u7403\u6700\u6b0a\u5a01\u671f\u520a\u4e0a\uff0c\u4ee3\u8868\u4e86\u4e2d\u570b\u85e5\u7269\u7814\u767c\u80fd\u529b\u8207\u751f\u7269\u79d1\u6280\u5275\u65b0\u6c34\u5e73\u9081\u4e0a\u4e86\u65b0\u53f0\u968e\u3002<\/b><\/p>\n<p><b>\u746a\u4ed5\u5ea6\u80bd\u9810\u8a08\u4eca\u5e74\u5728\u570b\u5167\u4e0a\u5e02\uff0c\u5c07\u7372\u6279\u6e1b\u91cd\u964d\u7cd6\u5169\u9805\u9069\u61c9\u75c7\u3002\u56e0\u51fa\u8272\u7684\u6e1b\u91cd\u7642\u6548\u548c\u5168\u9762\u7684\u4ee3\u8b1d\u7372\u76ca\uff0c\u746a\u4ed5\u5ea6\u80bd\u7372\u8a55<\/b><b>2025\u5e74\u5168\u7403\u5341\u5927\u6700\u53d7\u671f\u5f85\u85e5\u7269\u4e4b\u4e00\uff08FIERCE Pharma 2025\uff09\u3002\u6b64\u524d\u81e8\u5e8a\u7814\u7a76\u8868\u660e<sup>[i],[ii]<\/sup>\uff1a\u4f7f\u7528\u746a\u4ed5\u5ea6\u80bd\u9ad4\u91cd\u964d\u5e45\u905421%\uff0c\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf\u8d85 80%\uff0c\u8170\u570d\u6e1b\u5c11\u905411cm\uff0c\u9838\u570d\u6e1b\u5c11\u63a5\u8fd13cm\uff0c\u517c\u9867\u6539\u5584\u8840\u58d3\u3001\u8840\u8102\u3001\u8840\u5c3f\u9178\u548c\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u591a\u91cd\u4ee3\u8b1d\u6307\u6a19\u3002\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u6709\u6548\u964d\u4f4e\u7cd6\u5316\u8840\u7d05\u86cb\u767d\u90542.15%\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/b><\/p>\n<p class=\"prntaj\">\u91dd\u5c0d\u9019\u9805\u6700\u65b0\u767c\u5e03\u7684\u91cd\u78c5\u7814\u7a76\uff0c\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\u6ce2\u58eb\u9813\u5e03\u840a\u6839\u5a66\u5973\u91ab\u9662 <span class=\"xn-person\">Vanita R. Aroda<\/span> \u6559\u6388\u8207\u79d1\u7f85\u62c9\u591a\u5927\u5b78\u5b89\u8212\u8328\u91ab\u5b78\u9662 <span class=\"xn-person\">Leigh Perreault<\/span> \u6559\u6388<span id=\"spanHghlt0a69\">\u540c\u6b65\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u4f48\u8a55\u8ad6\u6307\u51fa<\/span>\uff0cGLORY-1\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u7684\u4e2d\u570b\u4eba\u7279\u9ede\u8207\u897f\u65b9\u4eba\u4e0d\u540c\uff0c\u5728\u66f4\u52a0\u5e74\u8f15\u7684\u4eba\u7fa4\u4e2d\uff0c\u4ee3\u8b1d\u7570\u5e38\u6bd4\u4f8b\u4e0d\u4f4e\u751a\u81f3\u66f4\u9ad8\uff0c\u800cGCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\u6cbb\u7642\u4e0d\u50c5\u80fd\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u548cBMI\uff0c\u66f4\u80fd\u5168\u9762\u6539\u5584\u80a5\u80d6\u76f8\u95dc\u5168\u8eab\u6027\u5065\u5eb7\u98a8\u96aa\uff1b\u6b64\u5916\u4e2d\u570b\u80a5\u80d6\u5e72\u9810\u9700\u7d50\u5408\u672c\u571f\u4eba\u7fa4\u7279\u5fb5\u5be6\u65bd\u5dee\u7570\u5316\u7b56\u7565\uff0c\u91cd\u9ede\u95dc\u6ce8\u809d\u81df\u5065\u5eb7\u8207\u8840\u8102\u7ba1\u7406\u3002\u4e2d\u570b\u80a5\u80d6\u65e5\u76ca\u5e74\u8f15\u5316\uff0c\u793e\u6703\u8ca0\u64d4\u66f4\u91cd\uff0c\u56e0\u6b64\u8981\u66f4\u65e9\u5e72\u9810\uff0c\u4e26\u4e14\u5f9e\u65e9\u671f\u5e72\u9810\u4e5f\u6703\u5e36\u4f86\u66f4\u5927\u7372\u76ca\u3002\u5c0d\u65bc\u80a5\u80d6\u9818\u57df\u4e0d\u65b7\u6e67\u73fe\u7684\u65b0\u7642\u6cd5\uff0c\u5169\u4f4d\u5c08\u5bb6\u8a8d\u70ba\u85e5\u7269\u7642\u6cd5\u50c5\u662f\u80a5\u80d6\u9632\u63a7\u7684\u4e00\u74b0\uff0c\u9700\u8207\u516c\u5171\u885b\u751f\u653f\u7b56\u5354\u540c\u69cb\u5efa\u7d9c\u5408\u9632\u6cbb\u9ad4\u7cfb\uff0c\u4ee5\u66f4\u6709\u6548\u61c9\u5c0d\u5168\u7403\u80a5\u80d6\u8ca0\u64d4\u3002<\/p>\n<p><b>\u6b64\u6b21\u5165\u9078\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u7684\u7814\u7a76\u70ba\u746a\u4ed5\u5ea6\u80bd\u4e00\u9805\u4f4e\u5291\u91cf\u6e1b\u91cd\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76<\/b><b>GLORY-1\u3002<\/b>GLORY-1\u7814\u7a76\u5171\u5165\u7d44610\u4f8b\u80a5\u80d6\uff08BMI\u226528 kg\/m<sup>2<\/sup>\uff09\u6216\u8d85\u91cd\uff08 kg\/m<sup>2<\/sup>\u2264 BMI \uff1c28 kg\/m<sup>2<\/sup>\uff09\u4e26\u4f34\u6709\u81f3\u5c11\u4e00\u7a2e\u80a5\u80d6\u76f8\u95dc\u4e26\u767c\u75c7\u7684\u53d7\u8a66\u8005\uff0c\u96a8\u6a5f\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd 4 mg\u30016 mg\u548c\u5b89\u6170\u5291\uff0c\u6bcf\u5468\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e548\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u548c\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002<\/p>\n<p>\u53d7\u8a66\u8005\u57fa\u7dda\u5e73\u5747\u9ad4\u91cd\u70ba87.2 kg\uff0c\u57fa\u7dda\u5e73\u5747BMI\u70ba31.1 kg\/m<sup>2<\/sup>\u3002<b>\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u76f8\u8f03\u5b89\u6170\u5291\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u3002<\/b><\/p>\n<p>\u57fa\u65bc\u7642\u6548\u4f30\u8a08\u76ee\u6a19\uff1a\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba\u221210.97%\u3001\u221213.38%\u548c\u22120.24%\uff1b\u7b2c48\u5468\u6642\u5206\u5225\u70ba\u221212.05%\u3001\u221214.84%\u548c\u22120.47%\u3002\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905476.3%\u300184.0%\u548c10.9%\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905437.0%\u300150.6%\u548c2.1%\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u53ca\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u7d50\u679c\u5747\u986f\u793a\u4e86\u746a\u4ed5\u5ea6\u80bd\u4efb\u4e00\u5291\u91cf\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u512a\u6548\u6027\uff0cp\u503c\u5747\u5c0f\u65bc0.001\uff08\u4e3b\u8981\u7d50\u679c\u5982\u4e0b\uff09\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen3\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7642\u6548\u4f30\u8a08\u76ee\u6a19<\/b><b><span class=\"prnews_span\"><sup>1<\/sup><\/span><\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen3\" colspan=\"3\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19<\/b><b><span class=\"prnews_span\"><sup>2<\/sup><\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\" nowrap><\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u746a\u4ed5\u5ea6\u80bd<\/b><b>\u00a0<br \/>4 mg<br \/>(N=203)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u746a\u4ed5\u5ea6\u80bd<\/b><b>\u00a0<br \/>6 mg<br \/>(N=202)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5b89\u6170\u5291<\/b>\u00a0<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(N=205)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u746a\u4ed5\u5ea6\u80bd<\/b><b>\u00a0<br \/>4 mg<br \/>(N=203)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u746a\u4ed5\u5ea6\u80bd<\/b><b>\u00a0<br \/>6 mg<br \/>(N=202)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5b89\u6170\u5291<\/b>\u00a0<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>(N=205)<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"7\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e3b\u8981\u7d42\u9ede\uff08<\/b><b>32<\/b><b>\u5468\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221210.97%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221213.38%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u22120.24%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221210.09%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221212.55%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">0.45\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">76.3\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">84.0\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10.9\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">73.9\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">82.0\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10.5\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"7\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u90e8\u5206\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff08<\/b><b>48<\/b><b>\u5468\uff09<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221212.05%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221214.84%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u22120.47%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221211.00%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221214.01%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">0.30\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">73.5\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">82.8\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">11.5\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">71.6\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">81.6\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">10.8\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226510%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">55.2\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">67.9\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2.9\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">53.5\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">66.7\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2.6\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226515%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">37.0\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">50.6\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2.1\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">35.7\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">49.5\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">2.0\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u8170\u570d\u6e1b\u5c11<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u22129.48 cm<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221210.96 cm<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u22121.48 cm<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u22129.12 cm<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u221210.72 cm<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\" nowrap>\n<p class=\"prnml4\"><span class=\"prnews_span\">\u22121.41 cm<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">1\uff1a\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5728\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u7528\u85e5\u6216\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u4e4b\u524d\u7684\u7642\u6548\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2\uff1a\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u5b8c\u6210\u65b9\u6848\u8981\u6c42\u7684\u65e2\u5b9a\u6cbb\u7642\u548c\u662f\u5426\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u7684\u60c5\u6cc1\u4e0b\u7684\u7642\u6548\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><b>\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u8840\u58d3\u3001\u8840\u8102\uff08\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff09\u3001\u8840\u5c3f\u9178\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002<\/b><\/p>\n<p><b>\u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u4e86\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u3002<\/b><\/p>\n<ul type=\"disc\">\n<li>\u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u22655%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221263.26%\u3001\u221273.18%\u548c+8.20%\uff1b<\/li>\n<li>\u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u226510%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221265.85%\u3001\u221280.24%\u548c\u22125.27%\u3002<\/li>\n<\/ul>\n<p><b>\u746a\u4ed5\u5ea6\u80bd\u7e3d\u9ad4\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d<\/b>\u3002<\/p>\n<ul type=\"disc\">\n<li>\u746a\u4ed5\u5ea6\u80bd\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5f81\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6GLP-1\u53d7\u9ad4\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u5831\u544a\u7684\u6cbb\u7642\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u60e1\u5fc3\u3001\u8179\u7009\u548c\u5614\u5410\uff0c\u5927\u591a\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\u3002<\/li>\n<li>\u7814\u7a76\u671f\u9593\u672a\u898b\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/li>\n<\/ul>\n<p><b>\u8a72\u7814\u7a76\u7684\u727d\u982d\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388<\/b>\u8868\u793a\uff1a\u300c\u9577\u671f\u4ee5\u4f86\uff0c\u5168\u7403\u80a5\u80d6\u8a3a\u7642\u6307\u5357\u4e3b\u8981\u57fa\u65bc\u767d\u4eba\u4eba\u7fa4\u6578\u64da\uff0c\u5c0d\u4e9e\u6d32\u4eba\u7fa4\u7684\u9069\u7528\u6027\u5b58\u5728\u504f\u5dee\u3002\u8207\u6b64\u540c\u6642\uff0c\u76f8\u6bd4\u6b50\u7f8e\u4eba\u7fa4\uff0c\u4e2d\u570b\u8d85\u91cd\u80a5\u80d6\u4eba\u7fa4\u6709\u8457\u7368\u7279\u7684\u75be\u75c5\u7279\u9ede\u53ca\u6cbb\u7642\u9700\u6c42\uff0c\u4e9f\u9700\u4ee5\u4e2d\u570b\u8b49\u64da\uff0c\u6307\u5c0e\u4e2d\u570b\u8d85\u91cd\u80a5\u80d6\u4eba\u7fa4\u7684\u9ad4\u91cd\u7ba1\u7406\u3002\u5c0d\u65bc\u4e2d\u570b\u5927\u591a\u6578\u8d85\u91cd\u548c\u8f15\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\uff0c\u6e1b\u91cd\u76ee\u6a19\u61c9\u8a2d\u5b9a\u70ba\uff1a\u57283-6\u500b\u6708\u4e4b\u5167\u81f3\u5c11\u5c07\u9ad4\u91cd\u964d\u4f4e5%-15%\u4e26\u7dad\u6301\uff1b\u5c0d\u65bc\u4e2d\u3001\u91cd\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\u5247\u53ef\u8a2d\u5b9a\u66f4\u9ad8\u7684\u6e1b\u91cd\u76ee\u6a19\u3002GLORY-1\u7814\u7a76\u4eba\u7fa4\u5168\u90e8\u4f86\u81ea\u4e2d\u570b\u4eba\u7fa4\uff0c\u7b26\u5408\u4e0a\u8ff0\u4e2d\u570b\u4eba\u7fa4\u6e1b\u91cd\u76ee\u6a19\u7684\u8a2d\u5b9a\uff0c\u7814\u7a76\u4e2d\u746a\u4ed5\u5ea6\u80bd\u7684\u6e1b\u91cd\u6578\u64da\u5341\u5206\u4ee4\u4eba\u632f\u596e\uff0c\u8fd1\u534a\u6578\u60a3\u8005\u6e1b\u91cd\u5e45\u5ea6&gt;15%\uff0c\u9019\u63d0\u793a\uff0c\u5c0d\u65bc\u8d85\u91cd\u3001\u8f15\u5ea6\u548c\u4e2d\u91cd\u5ea6\u80a5\u80d6\u60a3\u8005\uff0c\u746a\u4ed5\u5ea6\u80bd\u5747\u80fd\u5920\u5e6b\u52a9\u5176\u986f\u8457\u63a7\u5236\u9ad4\u91cd\uff0c\u5b8c\u6210\u6e1b\u91cd\u76ee\u6a19\u3002\u746a\u4ed5\u5ea6\u80bdGLORY-1\u7814\u7a76\u898b\u520a\u65bc\u5168\u7403\u6700\u6b0a\u5a01\u7684\u81e8\u5e8a\u91ab\u5b78\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff0c\u4e0d\u50c5\u4ee3\u8868\u4e86\u4e2d\u570b\u5728\u5167\u5206\u6ccc\u4ee3\u8b1d\u9818\u57df\u7684\u5275\u65b0\u7814\u7a76\u6210\u679c\u5f97\u5230\u4e86\u570b\u969b\u8a8d\u53ef\uff0c\u4e5f\u518d\u6b21\u8b49\u5be6\u4e2d\u570b\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u80fd\u529b\u8207\u751f\u7269\u79d1\u6280\u5275\u65b0\u6c34\u5e73\u5df2\u8d70\u5728\u4e86\u5168\u7403\u524d\u5217\u3002\u746a\u4ed5\u5ea6\u80bd\u7684\u7814\u767c\u6210\u529f\u5c07\u52a0\u901f\u672c\u571f\u4f01\u696d\u5728\u80a5\u80d6\u7ba1\u7406\u9818\u57df\u7684\u5e03\u5c40\uff0c\u70ba\u4e2d\u570b\u8d85\u91cd\u80a5\u80d6\u60a3\u8005\u63d0\u4f9b\u66f4\u5177\u500b\u6027\u5316\u7684\u5168\u5468\u671f\u7ba1\u7406\u65b9\u6848\u3002\u300d<\/p>\n<p><b>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9322\u9433\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u746a\u4ed5\u5ea6\u80bd\u662f\u5168\u7403GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\u4e2d\u7b2c\u4e00\u500b\u5373\u5c07\u7372\u6279\u7684\u5206\u5b50\uff0c\u5176\u6ce8\u518a\u7814\u7a76GLORY-1\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u7684\u767c\u8868\u70ba\u4e2d\u570b\u5167\u5206\u6ccc\u4ee3\u8b1d\u9818\u57df\u65b0\u85e5\u81e8\u5e8a\u7814\u7a76\u5be6\u73fe\u4e86\u96f6\u7684\u7a81\u7834\uff0c\u4e5f\u70ba\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u7684\u81e8\u5e8a\u6cbb\u7642\u63d0\u4f9b\u4e86\u9ad8\u8cea\u91cf\u7684\u5faa\u8b49\u91ab\u5b78\u8b49\u64da\uff0c\u672a\u4f86\u5fc5\u5c07\u6539\u5beb\u6307\u5357\u8207\u81e8\u5e8a\u8a3a\u7642\u5be6\u8e10\u3002\u9019\u4e00\u5b78\u8853\u6210\u679c\u540c\u6642\u8b49\u660e\u4e86\u6211\u570b\u7814\u7a76\u8005\u5353\u8d8a\u7684\u81e8\u5e8a\u7814\u7a76\u6c34\u5e73\u548c\u4e2d\u570b\u5275\u65b0\u88fd\u85e5\u4f01\u696d\u624e\u5be6\u7684\u5275\u65b0\u7814\u767c\u80fd\u529b\u3002\u746a\u4ed5\u5ea6\u80bd\u5373\u5c07\u5728\u4e2d\u570b\u7372\u6279\u4e0a\u5e02\uff0c\u6211\u5011\u671f\u5f85\u746a\u4ed5\u5ea6\u80bd\u70ba\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u5e36\u4f86\u66f4\u591a\u548c\u66f4\u512a\u7684\u6cbb\u7642\u9078\u64c7\uff0c\u70ba\u751f\u6d3b\u66f4\u6dfb\u7f8e\u597d\u3002\u4f5c\u70ba\u5275\u65b0\u85e5\u4f01\u696d\uff0c\u4fe1\u9054\u751f\u7269\u7a4d\u6975\u97ff\u61c9\u570b\u5bb6\u865f\u53ec\uff0c\u8207\u6709\u95dc\u5404\u65b9\u651c\u624b\u540c\u884c\uff0c\u4ee5\u524d\u6cbf\u91ab\u5b78\u6210\u679c\u52a9\u529b\u5168\u6c11\u79d1\u5b78\u6e1b\u91cd\u3001\u63a8\u9032\u5065\u5eb7\u4e2d\u570b\u5ef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type=\"disc\">\n<li>\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\uff1b<\/li>\n<li>\u5728\u4e2d\u570b\u4e2d\u91cd\u5ea6\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-2\uff09\uff1b<\/li>\n<li>\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u5408\u4e26MAFLD\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-3\uff09;<\/li>\n<li>\u5728\u521d\u6cbb\u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u958b\u5c55\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08DREAMS-1\uff09\uff1b<\/li>\n<li>\u5728\u53e3\u670d\u85e5\u7269\u6cbb\u7642\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u7684\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u5c0d\u6bd4\u746a\u4ed5\u5ea6\u80bd\u548c\u5ea6\u62c9\u7cd6\u80bd\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08DREAMS-2\uff09\uff1b<\/li>\n<li>\u5728\u4e2d\u570b2\u578b\u7cd6\u5c3f\u75c5\u5408\u4e26\u80a5\u80d6\u7684\u53d7\u8a66\u8005\u4e2d\u958b\u5c55\u7684\u5c0d\u6bd4\u746a\u4ed5\u5ea6\u80bd\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08DREAMS-3\uff09\u3002<\/li>\n<\/ul>\n<p>\u5176\u4e2d\uff0cGLORY-1\u3001DREAMS-1\u548cDREAMS-2\u7814\u7a76\u5747\u5df2\u9054\u6210\u7d42\u9ede\uff0c\u5176\u4ed6\u7814\u7a76\u9084\u5728\u9032\u884c\u4e2d\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u7684\u591a\u9805\u65b0\u81e8\u5e8a\u7814\u7a76\u8a08\u5283\u555f\u52d5\uff0c\u5176\u4e2d\u5305\u62ec\u6cbb\u7642\u9752\u5c11\u5e74\u80a5\u80d6\u548c\u963b\u585e\u6027\u7761\u7720\u547c\u5438\u66ab\u505c\uff08OSA\uff09\u7684\u5169\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u4ee5\u53ca\u6cbb\u7642\u4ee3\u8b1d\u76f8\u95dc\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u3001\u5c04\u8840\u5206\u6578\u4fdd\u7559\u5fc3\u529b\u8870\u7aed\uff08HFpEF\uff09\u7b49\u65b0\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p><b>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n<p>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670915\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<sup>\u00ae<\/sup>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<sup>\u00ae<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<sup>\u00ae<\/sup>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\uff0c \u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607<sup>\u00ae<\/sup>\uff09\uff0c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02<sup>\u00ae<\/sup>\uff09\uff0c\u6c1f\u6fa4\u96f7\u585e\u7247\uff08\u9054\u4f2f\u7279<sup>\u00ae<\/sup>\uff09\uff0c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247\uff08\u6377\u5e15\u529b<sup>\u00ae<\/sup>\uff09\uff0c\u5df1\u4e8c\u9178\u4ed6\u96f7\u66ff\u5c3c\u81a0\u56ca\uff08\u9054\u4f2f\u6a02<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u5384\u66ff\u5c3c\u7247\uff08\u5967\u58f9\u65b0<sup>\u00ae<\/sup>\uff09\u548c\u66ff\u59a5\u5c24\u55ae\u6297N01\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u654f<sup>\u00ae<\/sup>\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u67093\u500b\u54c1\u7a2e\u5728NMPA\u5be9\u8a55\u4e2d\uff0c4\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165III\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u670915\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001Incyte\u548cMD Anderson 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href=\"https:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\" style=\"color: #0000FF\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"https:\/\/www.linkedin.com\/\" target=\"_blank\" rel=\"nofollow noopener\" style=\"color: #0000FF\">www.linkedin.com\/<\/a><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i>\u8072\u660e\uff1a<\/i><i>1.\u4fe1\u9054\u751f\u7269\u4e0d\u63a8\u85a6\u672a\u7372\u6279\u7684\u85e5\u54c1\/\u9069\u61c9\u75c7\u7684\u4f7f\u7528\u3002<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i>2.\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<sup>\u00ae<\/sup>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<sup>\u00ae<\/sup>\uff09\u548c\u5339\u59a5\u5e03\u66ff\u5c3c\u7247\uff08\u6377\u5e15\u529b<sup>\u00ae<\/sup>\uff09\u7531\u79ae\u4f86\u516c\u53f8\u7814\u767c<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p><b>\u524d\u77bb\u6027\u8072\u660e<\/b><\/p>\n<p>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u5e03\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0\u3002<\/p>\n<p>\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225\u3002<\/p>\n<p>\u53c3\u8003\u6587\u737b<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[i] JI L, et al. 1856-LB: Efficacy and Safety of Mazdutide in Chinese Participants with Overweight or Obesity (GLORY-1)[J]. Diabetes, 2024, 73(Supplement_1).<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[ii]\u00a0Mazdutide reduces body weight in adults with overweight or obesity: a multiple-dose study.2024 EASD Abstract # 734.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[iii]\u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373-92.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen6\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[iv] Institute for Health Metrics and Evaluation. Global Health Data Exchange. GBD results tool. <a href=\"http:\/\/ghdx.healthdata.org\/gbd-resultstool\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\" style=\"color: #0000FF\">http:\/\/ghdx.healthdata.org\/gbd-resultstool<\/a>\u00a0(accessed Jan 10, 2021).<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2025\u5e74&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-329065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u69ae\u8000\u767b\u9802 | \u5168\u7403\u9996\u6b3e\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u746a\u4ed5\u5ea6\u80bd\u7684\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u5e03 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2025\u5e745\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\uff08GCG\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u746a\u4ed5\u5ea6\u80bd\uff0c\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\u7d50\u679c\u8fd1\u65e5\u5728\u570b\u969b\u77e5\u540d\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08The New England Journal of Medicine, NEJM\uff09\u5168\u6587\u5728\u7dda\u767c\u8868\u4e26\u7279\u914d\u5c08\u5bb6\u8a55\u8ff0\u3002\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\u5206\u5225\u70ba\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u6cb3\u5357\u79d1\u6280\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u59dc\u5b8f\u885b\u6559\u6388\uff0c\u53e6\u5916\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9322\u9433\u535a\u58eb\u70ba\u672c\u6587\u5171\u540c\u901a\u8a0a\u4f5c\u8005\u3002 \u9019\u662f\u5168\u7403\u9996\u500b\u4e14\u552f\u4e00\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u7684\u81e8\u5e8a\u7814\u7a76\u7b2c\u4e00\u6b21\u767b\u9802\u91ab\u5b78\u6b0a\u5a01\u5b78\u8853\u671f\u520a\uff0c\u5c07\u6539\u5beb\u570b\u5167\u5916\u8d85\u91cd\u548c\u80a5\u80d6\u75be\u75c5\u7684\u81e8\u5e8a\u6cbb\u7642\u548c\u6307\u5357\u3002\u5728\u4e2d\u570b\u4ee3\u8b1d\u548c\u5167\u5206\u6ccc\u75be\u75c5\u9818\u57df\uff0c\u7b2c\u4e00\u6b21\u6709\u5275\u65b0\u85e5\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u5168\u7403\u6700\u6b0a\u5a01\u671f\u520a\u4e0a\uff0c\u4ee3\u8868\u4e86\u4e2d\u570b\u85e5\u7269\u7814\u767c\u80fd\u529b\u8207\u751f\u7269\u79d1\u6280\u5275\u65b0\u6c34\u5e73\u9081\u4e0a\u4e86\u65b0\u53f0\u968e\u3002 \u746a\u4ed5\u5ea6\u80bd\u9810\u8a08\u4eca\u5e74\u5728\u570b\u5167\u4e0a\u5e02\uff0c\u5c07\u7372\u6279\u6e1b\u91cd\u964d\u7cd6\u5169\u9805\u9069\u61c9\u75c7\u3002\u56e0\u51fa\u8272\u7684\u6e1b\u91cd\u7642\u6548\u548c\u5168\u9762\u7684\u4ee3\u8b1d\u7372\u76ca\uff0c\u746a\u4ed5\u5ea6\u80bd\u7372\u8a552025\u5e74\u5168\u7403\u5341\u5927\u6700\u53d7\u671f\u5f85\u85e5\u7269\u4e4b\u4e00\uff08FIERCE Pharma 2025\uff09\u3002\u6b64\u524d\u81e8\u5e8a\u7814\u7a76\u8868\u660e,\uff1a\u4f7f\u7528\u746a\u4ed5\u5ea6\u80bd\u9ad4\u91cd\u964d\u5e45\u905421%\uff0c\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf\u8d85 80%\uff0c\u8170\u570d\u6e1b\u5c11\u905411cm\uff0c\u9838\u570d\u6e1b\u5c11\u63a5\u8fd13cm\uff0c\u517c\u9867\u6539\u5584\u8840\u58d3\u3001\u8840\u8102\u3001\u8840\u5c3f\u9178\u548c\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u591a\u91cd\u4ee3\u8b1d\u6307\u6a19\u3002\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u6709\u6548\u964d\u4f4e\u7cd6\u5316\u8840\u7d05\u86cb\u767d\u90542.15%\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u91dd\u5c0d\u9019\u9805\u6700\u65b0\u767c\u5e03\u7684\u91cd\u78c5\u7814\u7a76\uff0c\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\u6ce2\u58eb\u9813\u5e03\u840a\u6839\u5a66\u5973\u91ab\u9662 Vanita R. Aroda \u6559\u6388\u8207\u79d1\u7f85\u62c9\u591a\u5927\u5b78\u5b89\u8212\u8328\u91ab\u5b78\u9662 Leigh Perreault \u6559\u6388\u540c\u6b65\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u4f48\u8a55\u8ad6\u6307\u51fa\uff0cGLORY-1\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u7684\u4e2d\u570b\u4eba\u7279\u9ede\u8207\u897f\u65b9\u4eba\u4e0d\u540c\uff0c\u5728\u66f4\u52a0\u5e74\u8f15\u7684\u4eba\u7fa4\u4e2d\uff0c\u4ee3\u8b1d\u7570\u5e38\u6bd4\u4f8b\u4e0d\u4f4e\u751a\u81f3\u66f4\u9ad8\uff0c\u800cGCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\u6cbb\u7642\u4e0d\u50c5\u80fd\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u548cBMI\uff0c\u66f4\u80fd\u5168\u9762\u6539\u5584\u80a5\u80d6\u76f8\u95dc\u5168\u8eab\u6027\u5065\u5eb7\u98a8\u96aa\uff1b\u6b64\u5916\u4e2d\u570b\u80a5\u80d6\u5e72\u9810\u9700\u7d50\u5408\u672c\u571f\u4eba\u7fa4\u7279\u5fb5\u5be6\u65bd\u5dee\u7570\u5316\u7b56\u7565\uff0c\u91cd\u9ede\u95dc\u6ce8\u809d\u81df\u5065\u5eb7\u8207\u8840\u8102\u7ba1\u7406\u3002\u4e2d\u570b\u80a5\u80d6\u65e5\u76ca\u5e74\u8f15\u5316\uff0c\u793e\u6703\u8ca0\u64d4\u66f4\u91cd\uff0c\u56e0\u6b64\u8981\u66f4\u65e9\u5e72\u9810\uff0c\u4e26\u4e14\u5f9e\u65e9\u671f\u5e72\u9810\u4e5f\u6703\u5e36\u4f86\u66f4\u5927\u7372\u76ca\u3002\u5c0d\u65bc\u80a5\u80d6\u9818\u57df\u4e0d\u65b7\u6e67\u73fe\u7684\u65b0\u7642\u6cd5\uff0c\u5169\u4f4d\u5c08\u5bb6\u8a8d\u70ba\u85e5\u7269\u7642\u6cd5\u50c5\u662f\u80a5\u80d6\u9632\u63a7\u7684\u4e00\u74b0\uff0c\u9700\u8207\u516c\u5171\u885b\u751f\u653f\u7b56\u5354\u540c\u69cb\u5efa\u7d9c\u5408\u9632\u6cbb\u9ad4\u7cfb\uff0c\u4ee5\u66f4\u6709\u6548\u61c9\u5c0d\u5168\u7403\u80a5\u80d6\u8ca0\u64d4\u3002 \u6b64\u6b21\u5165\u9078\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u7684\u7814\u7a76\u70ba\u746a\u4ed5\u5ea6\u80bd\u4e00\u9805\u4f4e\u5291\u91cf\u6e1b\u91cd\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORY-1\u3002GLORY-1\u7814\u7a76\u5171\u5165\u7d44610\u4f8b\u80a5\u80d6\uff08BMI\u226528 kg\/m2\uff09\u6216\u8d85\u91cd\uff08 kg\/m2\u2264 BMI \uff1c28 kg\/m2\uff09\u4e26\u4f34\u6709\u81f3\u5c11\u4e00\u7a2e\u80a5\u80d6\u76f8\u95dc\u4e26\u767c\u75c7\u7684\u53d7\u8a66\u8005\uff0c\u96a8\u6a5f\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd 4 mg\u30016 mg\u548c\u5b89\u6170\u5291\uff0c\u6bcf\u5468\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e548\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u548c\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002 \u53d7\u8a66\u8005\u57fa\u7dda\u5e73\u5747\u9ad4\u91cd\u70ba87.2 kg\uff0c\u57fa\u7dda\u5e73\u5747BMI\u70ba31.1 kg\/m2\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u76f8\u8f03\u5b89\u6170\u5291\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u3002 \u57fa\u65bc\u7642\u6548\u4f30\u8a08\u76ee\u6a19\uff1a\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba\u221210.97%\u3001\u221213.38%\u548c\u22120.24%\uff1b\u7b2c48\u5468\u6642\u5206\u5225\u70ba\u221212.05%\u3001\u221214.84%\u548c\u22120.47%\u3002\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905476.3%\u300184.0%\u548c10.9%\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905437.0%\u300150.6%\u548c2.1%\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u53ca\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u7d50\u679c\u5747\u986f\u793a\u4e86\u746a\u4ed5\u5ea6\u80bd\u4efb\u4e00\u5291\u91cf\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u512a\u6548\u6027\uff0cp\u503c\u5747\u5c0f\u65bc0.001\uff08\u4e3b\u8981\u7d50\u679c\u5982\u4e0b\uff09\u3002             \u7642\u6548\u4f30\u8a08\u76ee\u6a191    \u7642\u6cd5\u4f30\u8a08\u76ee\u6a192            \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203)    \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202)    \u5b89\u6170\u5291\u00a0 (N=205)    \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203)    \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202)    \u5b89\u6170\u5291\u00a0 (N=205)         \u4e3b\u8981\u7d42\u9ede\uff0832\u5468\uff09         \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4    \u221210.97%    \u221213.38%    \u22120.24%    \u221210.09%    \u221212.55%    0.45\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%    76.3\u00a0%    84.0\u00a0%    10.9\u00a0%    73.9\u00a0%    82.0\u00a0%    10.5\u00a0%         \u90e8\u5206\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0848\u5468\uff09         \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4    \u221212.05%    \u221214.84%    \u22120.47%    \u221211.00%    \u221214.01%    0.30\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%    73.5\u00a0%    82.8\u00a0%    11.5\u00a0%    71.6\u00a0%    81.6\u00a0%    10.8\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226510%    55.2\u00a0%    67.9\u00a0%    2.9\u00a0%    53.5\u00a0%    66.7\u00a0%    2.6\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226515%    37.0\u00a0%    50.6\u00a0%    2.1\u00a0%    35.7\u00a0%    49.5\u00a0%    2.0\u00a0%         \u8170\u570d\u6e1b\u5c11    \u22129.48 cm    \u221210.96 cm    \u22121.48 cm    \u22129.12 cm    \u221210.72 cm    \u22121.41 cm         \u00a0          1\uff1a\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5728\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u7528\u85e5\u6216\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u4e4b\u524d\u7684\u7642\u6548\u3002         2\uff1a\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u5b8c\u6210\u65b9\u6848\u8981\u6c42\u7684\u65e2\u5b9a\u6cbb\u7642\u548c\u662f\u5426\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u7684\u60c5\u6cc1\u4e0b\u7684\u7642\u6548\u3002         \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u8840\u58d3\u3001\u8840\u8102\uff08\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff09\u3001\u8840\u5c3f\u9178\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002 \u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u4e86\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u3002   \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u22655%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221263.26%\u3001\u221273.18%\u548c+8.20%\uff1b  \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u226510%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221265.85%\u3001\u221280.24%\u548c\u22125.27%\u3002  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\u53c3\u8003\u6587\u737b           JI L, et al. 1856-LB: Efficacy and Safety of Mazdutide in Chinese Participants with Overweight or Obesity (GLORY-1). Diabetes, 2024, 73(Supplement_1).         \u00a0Mazdutide reduces body weight in adults with overweight or obesity: a multiple-dose study.2024 EASD Abstract # 734.         \u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373-92.         Institute for Health Metrics and Evaluation. Global Health Data Exchange. GBD results tool. http:\/\/ghdx.healthdata.org\/gbd-resultstool\u00a0(accessed Jan 10, 2021).         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=329065\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u69ae\u8000\u767b\u9802 | \u5168\u7403\u9996\u6b3e\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u746a\u4ed5\u5ea6\u80bd\u7684\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u5e03 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2025\u5e745\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\uff08GCG\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u746a\u4ed5\u5ea6\u80bd\uff0c\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\u7d50\u679c\u8fd1\u65e5\u5728\u570b\u969b\u77e5\u540d\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08The New England Journal of Medicine, NEJM\uff09\u5168\u6587\u5728\u7dda\u767c\u8868\u4e26\u7279\u914d\u5c08\u5bb6\u8a55\u8ff0\u3002\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\u5206\u5225\u70ba\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u6cb3\u5357\u79d1\u6280\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u59dc\u5b8f\u885b\u6559\u6388\uff0c\u53e6\u5916\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9322\u9433\u535a\u58eb\u70ba\u672c\u6587\u5171\u540c\u901a\u8a0a\u4f5c\u8005\u3002 \u9019\u662f\u5168\u7403\u9996\u500b\u4e14\u552f\u4e00\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u7684\u81e8\u5e8a\u7814\u7a76\u7b2c\u4e00\u6b21\u767b\u9802\u91ab\u5b78\u6b0a\u5a01\u5b78\u8853\u671f\u520a\uff0c\u5c07\u6539\u5beb\u570b\u5167\u5916\u8d85\u91cd\u548c\u80a5\u80d6\u75be\u75c5\u7684\u81e8\u5e8a\u6cbb\u7642\u548c\u6307\u5357\u3002\u5728\u4e2d\u570b\u4ee3\u8b1d\u548c\u5167\u5206\u6ccc\u75be\u75c5\u9818\u57df\uff0c\u7b2c\u4e00\u6b21\u6709\u5275\u65b0\u85e5\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u5168\u7403\u6700\u6b0a\u5a01\u671f\u520a\u4e0a\uff0c\u4ee3\u8868\u4e86\u4e2d\u570b\u85e5\u7269\u7814\u767c\u80fd\u529b\u8207\u751f\u7269\u79d1\u6280\u5275\u65b0\u6c34\u5e73\u9081\u4e0a\u4e86\u65b0\u53f0\u968e\u3002 \u746a\u4ed5\u5ea6\u80bd\u9810\u8a08\u4eca\u5e74\u5728\u570b\u5167\u4e0a\u5e02\uff0c\u5c07\u7372\u6279\u6e1b\u91cd\u964d\u7cd6\u5169\u9805\u9069\u61c9\u75c7\u3002\u56e0\u51fa\u8272\u7684\u6e1b\u91cd\u7642\u6548\u548c\u5168\u9762\u7684\u4ee3\u8b1d\u7372\u76ca\uff0c\u746a\u4ed5\u5ea6\u80bd\u7372\u8a552025\u5e74\u5168\u7403\u5341\u5927\u6700\u53d7\u671f\u5f85\u85e5\u7269\u4e4b\u4e00\uff08FIERCE Pharma 2025\uff09\u3002\u6b64\u524d\u81e8\u5e8a\u7814\u7a76\u8868\u660e,\uff1a\u4f7f\u7528\u746a\u4ed5\u5ea6\u80bd\u9ad4\u91cd\u964d\u5e45\u905421%\uff0c\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf\u8d85 80%\uff0c\u8170\u570d\u6e1b\u5c11\u905411cm\uff0c\u9838\u570d\u6e1b\u5c11\u63a5\u8fd13cm\uff0c\u517c\u9867\u6539\u5584\u8840\u58d3\u3001\u8840\u8102\u3001\u8840\u5c3f\u9178\u548c\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u591a\u91cd\u4ee3\u8b1d\u6307\u6a19\u3002\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u6709\u6548\u964d\u4f4e\u7cd6\u5316\u8840\u7d05\u86cb\u767d\u90542.15%\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u91dd\u5c0d\u9019\u9805\u6700\u65b0\u767c\u5e03\u7684\u91cd\u78c5\u7814\u7a76\uff0c\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\u6ce2\u58eb\u9813\u5e03\u840a\u6839\u5a66\u5973\u91ab\u9662 Vanita R. Aroda \u6559\u6388\u8207\u79d1\u7f85\u62c9\u591a\u5927\u5b78\u5b89\u8212\u8328\u91ab\u5b78\u9662 Leigh Perreault 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mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905437.0%\u300150.6%\u548c2.1%\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u53ca\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u7d50\u679c\u5747\u986f\u793a\u4e86\u746a\u4ed5\u5ea6\u80bd\u4efb\u4e00\u5291\u91cf\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u512a\u6548\u6027\uff0cp\u503c\u5747\u5c0f\u65bc0.001\uff08\u4e3b\u8981\u7d50\u679c\u5982\u4e0b\uff09\u3002             \u7642\u6548\u4f30\u8a08\u76ee\u6a191    \u7642\u6cd5\u4f30\u8a08\u76ee\u6a192            \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203)    \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202)    \u5b89\u6170\u5291\u00a0 (N=205)    \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203)    \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202)    \u5b89\u6170\u5291\u00a0 (N=205)         \u4e3b\u8981\u7d42\u9ede\uff0832\u5468\uff09         \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4    \u221210.97%    \u221213.38%    \u22120.24%    \u221210.09%    \u221212.55%    0.45\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%    76.3\u00a0%    84.0\u00a0%    10.9\u00a0%    73.9\u00a0%    82.0\u00a0%    10.5\u00a0%         \u90e8\u5206\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0848\u5468\uff09         \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4    \u221212.05%    \u221214.84%    \u22120.47%    \u221211.00%    \u221214.01%    0.30\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%    73.5\u00a0%    82.8\u00a0%    11.5\u00a0%    71.6\u00a0%    81.6\u00a0%    10.8\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226510%    55.2\u00a0%    67.9\u00a0%    2.9\u00a0%    53.5\u00a0%    66.7\u00a0%    2.6\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226515%    37.0\u00a0%    50.6\u00a0%    2.1\u00a0%    35.7\u00a0%    49.5\u00a0%    2.0\u00a0%         \u8170\u570d\u6e1b\u5c11    \u22129.48 cm    \u221210.96 cm    \u22121.48 cm    \u22129.12 cm    \u221210.72 cm    \u22121.41 cm         \u00a0          1\uff1a\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5728\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u7528\u85e5\u6216\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u4e4b\u524d\u7684\u7642\u6548\u3002         2\uff1a\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u5b8c\u6210\u65b9\u6848\u8981\u6c42\u7684\u65e2\u5b9a\u6cbb\u7642\u548c\u662f\u5426\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u7684\u60c5\u6cc1\u4e0b\u7684\u7642\u6548\u3002         \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u8840\u58d3\u3001\u8840\u8102\uff08\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff09\u3001\u8840\u5c3f\u9178\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002 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\u53c3\u8003\u6587\u737b           JI L, et al. 1856-LB: Efficacy and Safety of Mazdutide in Chinese Participants with Overweight or Obesity (GLORY-1). Diabetes, 2024, 73(Supplement_1).         \u00a0Mazdutide reduces body weight in adults with overweight or obesity: a multiple-dose study.2024 EASD Abstract # 734.         \u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373-92.         Institute for Health Metrics and Evaluation. Global Health Data Exchange. 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Aroda \u6559\u6388\u8207\u79d1\u7f85\u62c9\u591a\u5927\u5b78\u5b89\u8212\u8328\u91ab\u5b78\u9662 Leigh Perreault 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kg\uff0c\u57fa\u7dda\u5e73\u5747BMI\u70ba31.1 kg\\\/m2\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u76f8\u8f03\u5b89\u6170\u5291\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u3002 \u57fa\u65bc\u7642\u6548\u4f30\u8a08\u76ee\u6a19\uff1a\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba\u221210.97%\u3001\u221213.38%\u548c\u22120.24%\uff1b\u7b2c48\u5468\u6642\u5206\u5225\u70ba\u221212.05%\u3001\u221214.84%\u548c\u22120.47%\u3002\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905476.3%\u300184.0%\u548c10.9%\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905437.0%\u300150.6%\u548c2.1%\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u53ca\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u7d50\u679c\u5747\u986f\u793a\u4e86\u746a\u4ed5\u5ea6\u80bd\u4efb\u4e00\u5291\u91cf\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u512a\u6548\u6027\uff0cp\u503c\u5747\u5c0f\u65bc0.001\uff08\u4e3b\u8981\u7d50\u679c\u5982\u4e0b\uff09\u3002 \u7642\u6548\u4f30\u8a08\u76ee\u6a191 \u7642\u6cd5\u4f30\u8a08\u76ee\u6a192 \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202) \u5b89\u6170\u5291\u00a0 (N=205) \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202) \u5b89\u6170\u5291\u00a0 (N=205) \u4e3b\u8981\u7d42\u9ede\uff0832\u5468\uff09 \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4 \u221210.97% \u221213.38% \u22120.24% \u221210.09% \u221212.55% 0.45\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655% 76.3\u00a0% 84.0\u00a0% 10.9\u00a0% 73.9\u00a0% 82.0\u00a0% 10.5\u00a0% \u90e8\u5206\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0848\u5468\uff09 \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4 \u221212.05% \u221214.84% \u22120.47% \u221211.00% \u221214.01% 0.30\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655% 73.5\u00a0% 82.8\u00a0% 11.5\u00a0% 71.6\u00a0% 81.6\u00a0% 10.8\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226510% 55.2\u00a0% 67.9\u00a0% 2.9\u00a0% 53.5\u00a0% 66.7\u00a0% 2.6\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226515% 37.0\u00a0% 50.6\u00a0% 2.1\u00a0% 35.7\u00a0% 49.5\u00a0% 2.0\u00a0% \u8170\u570d\u6e1b\u5c11 \u22129.48 cm \u221210.96 cm \u22121.48 cm \u22129.12 cm \u221210.72 cm \u22121.41 cm \u00a0 1\uff1a\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5728\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u7528\u85e5\u6216\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u4e4b\u524d\u7684\u7642\u6548\u3002 2\uff1a\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u5b8c\u6210\u65b9\u6848\u8981\u6c42\u7684\u65e2\u5b9a\u6cbb\u7642\u548c\u662f\u5426\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u7684\u60c5\u6cc1\u4e0b\u7684\u7642\u6548\u3002 \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u8840\u58d3\u3001\u8840\u8102\uff08\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff09\u3001\u8840\u5c3f\u9178\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002 \u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u4e86\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u3002 \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u22655%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221263.26%\u3001\u221273.18%\u548c+8.20%\uff1b \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u226510%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221265.85%\u3001\u221280.24%\u548c\u22125.27%\u3002 \u746a\u4ed5\u5ea6\u80bd\u7e3d\u9ad4\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002 \u746a\u4ed5\u5ea6\u80bd\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5f81\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6GLP-1\u53d7\u9ad4\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u5831\u544a\u7684\u6cbb\u7642\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u60e1\u5fc3\u3001\u8179\u7009\u548c\u5614\u5410\uff0c\u5927\u591a\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\u3002 \u7814\u7a76\u671f\u9593\u672a\u898b\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 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\u53c3\u8003\u6587\u737b JI L, et al. 1856-LB: Efficacy and Safety of Mazdutide in Chinese Participants with Overweight or Obesity (GLORY-1). Diabetes, 2024, 73(Supplement_1). \u00a0Mazdutide reduces body weight in adults with overweight or obesity: a multiple-dose study.2024 EASD Abstract # 734. \u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373-92. Institute for Health Metrics and Evaluation. Global Health Data Exchange. 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\u6b64\u6b21\u5165\u9078\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u7684\u7814\u7a76\u70ba\u746a\u4ed5\u5ea6\u80bd\u4e00\u9805\u4f4e\u5291\u91cf\u6e1b\u91cd\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76GLORY-1\u3002GLORY-1\u7814\u7a76\u5171\u5165\u7d44610\u4f8b\u80a5\u80d6\uff08BMI\u226528 kg\/m2\uff09\u6216\u8d85\u91cd\uff08 kg\/m2\u2264 BMI \uff1c28 kg\/m2\uff09\u4e26\u4f34\u6709\u81f3\u5c11\u4e00\u7a2e\u80a5\u80d6\u76f8\u95dc\u4e26\u767c\u75c7\u7684\u53d7\u8a66\u8005\uff0c\u96a8\u6a5f\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd 4 mg\u30016 mg\u548c\u5b89\u6170\u5291\uff0c\u6bcf\u5468\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e548\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c32\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u548c\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u3002 \u53d7\u8a66\u8005\u57fa\u7dda\u5e73\u5747\u9ad4\u91cd\u70ba87.2 kg\uff0c\u57fa\u7dda\u5e73\u5747BMI\u70ba31.1 kg\/m2\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u76f8\u8f03\u5b89\u6170\u5291\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u3002 \u57fa\u65bc\u7642\u6548\u4f30\u8a08\u76ee\u6a19\uff1a\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba\u221210.97%\u3001\u221213.38%\u548c\u22120.24%\uff1b\u7b2c48\u5468\u6642\u5206\u5225\u70ba\u221212.05%\u3001\u221214.84%\u548c\u22120.47%\u3002\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905476.3%\u300184.0%\u548c10.9%\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905437.0%\u300150.6%\u548c2.1%\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u53ca\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u7d50\u679c\u5747\u986f\u793a\u4e86\u746a\u4ed5\u5ea6\u80bd\u4efb\u4e00\u5291\u91cf\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u512a\u6548\u6027\uff0cp\u503c\u5747\u5c0f\u65bc0.001\uff08\u4e3b\u8981\u7d50\u679c\u5982\u4e0b\uff09\u3002             \u7642\u6548\u4f30\u8a08\u76ee\u6a191    \u7642\u6cd5\u4f30\u8a08\u76ee\u6a192            \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203)    \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202)    \u5b89\u6170\u5291\u00a0 (N=205)    \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203)    \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202)    \u5b89\u6170\u5291\u00a0 (N=205)         \u4e3b\u8981\u7d42\u9ede\uff0832\u5468\uff09         \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4    \u221210.97%    \u221213.38%    \u22120.24%    \u221210.09%    \u221212.55%    0.45\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%    76.3\u00a0%    84.0\u00a0%    10.9\u00a0%    73.9\u00a0%    82.0\u00a0%    10.5\u00a0%         \u90e8\u5206\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0848\u5468\uff09         \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4    \u221212.05%    \u221214.84%    \u22120.47%    \u221211.00%    \u221214.01%    0.30\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655%    73.5\u00a0%    82.8\u00a0%    11.5\u00a0%    71.6\u00a0%    81.6\u00a0%    10.8\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226510%    55.2\u00a0%    67.9\u00a0%    2.9\u00a0%    53.5\u00a0%    66.7\u00a0%    2.6\u00a0%         \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226515%    37.0\u00a0%    50.6\u00a0%    2.1\u00a0%    35.7\u00a0%    49.5\u00a0%    2.0\u00a0%         \u8170\u570d\u6e1b\u5c11    \u22129.48 cm    \u221210.96 cm    \u22121.48 cm    \u22129.12 cm    \u221210.72 cm    \u22121.41 cm         \u00a0          1\uff1a\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5728\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u7528\u85e5\u6216\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u4e4b\u524d\u7684\u7642\u6548\u3002         2\uff1a\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u5b8c\u6210\u65b9\u6848\u8981\u6c42\u7684\u65e2\u5b9a\u6cbb\u7642\u548c\u662f\u5426\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u7684\u60c5\u6cc1\u4e0b\u7684\u7642\u6548\u3002         \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u8840\u58d3\u3001\u8840\u8102\uff08\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff09\u3001\u8840\u5c3f\u9178\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002 \u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u4e86\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u3002   \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u22655%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221263.26%\u3001\u221273.18%\u548c+8.20%\uff1b  \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u226510%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221265.85%\u3001\u221280.24%\u548c\u22125.27%\u3002  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\u53c3\u8003\u6587\u737b           JI L, et al. 1856-LB: Efficacy and Safety of Mazdutide in Chinese Participants with Overweight or Obesity (GLORY-1). Diabetes, 2024, 73(Supplement_1).         \u00a0Mazdutide reduces body weight in adults with overweight or obesity: a multiple-dose study.2024 EASD Abstract # 734.         \u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373-92.         Institute for Health Metrics and Evaluation. Global Health Data Exchange. GBD results tool. http:\/\/ghdx.healthdata.org\/gbd-resultstool\u00a0(accessed Jan 10, 2021).         \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=329065","og_locale":"zh_TW","og_type":"article","og_title":"\u69ae\u8000\u767b\u9802 | \u5168\u7403\u9996\u6b3e\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u746a\u4ed5\u5ea6\u80bd\u7684\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5728\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u5e03 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"\u7f8e\u570b\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2025\u5e745\u670826\u65e5 \/\u7f8e\u901a\u793e\/ -- \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a01801\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u53ca\u5fc3\u8840\u7ba1\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\uff1a\u80f0\u9ad8\u8840\u7cd6\u7d20\uff08GCG\uff09\/\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u96d9\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u746a\u4ed5\u5ea6\u80bd\uff0c\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\uff08GLORY-1\uff09\u7d50\u679c\u8fd1\u65e5\u5728\u570b\u969b\u77e5\u540d\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff08The New England Journal of Medicine, NEJM\uff09\u5168\u6587\u5728\u7dda\u767c\u8868\u4e26\u7279\u914d\u5c08\u5bb6\u8a55\u8ff0\u3002\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\u5206\u5225\u70ba\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u6cb3\u5357\u79d1\u6280\u5927\u5b78\u9644\u5c6c\u7b2c\u4e00\u91ab\u9662\u59dc\u5b8f\u885b\u6559\u6388\uff0c\u53e6\u5916\u7d00\u7acb\u8fb2\u6559\u6388\u548c\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9322\u9433\u535a\u58eb\u70ba\u672c\u6587\u5171\u540c\u901a\u8a0a\u4f5c\u8005\u3002 \u9019\u662f\u5168\u7403\u9996\u500b\u4e14\u552f\u4e00\u7533\u5831\u4e0a\u5e02\u7684GCG\/GLP-1\u96d9\u53d7\u9ad4\u6fc0\u52d5\u6e1b\u91cd\u964d\u7cd6\u85e5\u7269\u7684\u81e8\u5e8a\u7814\u7a76\u7b2c\u4e00\u6b21\u767b\u9802\u91ab\u5b78\u6b0a\u5a01\u5b78\u8853\u671f\u520a\uff0c\u5c07\u6539\u5beb\u570b\u5167\u5916\u8d85\u91cd\u548c\u80a5\u80d6\u75be\u75c5\u7684\u81e8\u5e8a\u6cbb\u7642\u548c\u6307\u5357\u3002\u5728\u4e2d\u570b\u4ee3\u8b1d\u548c\u5167\u5206\u6ccc\u75be\u75c5\u9818\u57df\uff0c\u7b2c\u4e00\u6b21\u6709\u5275\u65b0\u85e5\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u767c\u8868\u5728\u5168\u7403\u6700\u6b0a\u5a01\u671f\u520a\u4e0a\uff0c\u4ee3\u8868\u4e86\u4e2d\u570b\u85e5\u7269\u7814\u767c\u80fd\u529b\u8207\u751f\u7269\u79d1\u6280\u5275\u65b0\u6c34\u5e73\u9081\u4e0a\u4e86\u65b0\u53f0\u968e\u3002 \u746a\u4ed5\u5ea6\u80bd\u9810\u8a08\u4eca\u5e74\u5728\u570b\u5167\u4e0a\u5e02\uff0c\u5c07\u7372\u6279\u6e1b\u91cd\u964d\u7cd6\u5169\u9805\u9069\u61c9\u75c7\u3002\u56e0\u51fa\u8272\u7684\u6e1b\u91cd\u7642\u6548\u548c\u5168\u9762\u7684\u4ee3\u8b1d\u7372\u76ca\uff0c\u746a\u4ed5\u5ea6\u80bd\u7372\u8a552025\u5e74\u5168\u7403\u5341\u5927\u6700\u53d7\u671f\u5f85\u85e5\u7269\u4e4b\u4e00\uff08FIERCE Pharma 2025\uff09\u3002\u6b64\u524d\u81e8\u5e8a\u7814\u7a76\u8868\u660e,\uff1a\u4f7f\u7528\u746a\u4ed5\u5ea6\u80bd\u9ad4\u91cd\u964d\u5e45\u905421%\uff0c\u964d\u4f4e\u809d\u81df\u8102\u80aa\u542b\u91cf\u8d85 80%\uff0c\u8170\u570d\u6e1b\u5c11\u905411cm\uff0c\u9838\u570d\u6e1b\u5c11\u63a5\u8fd13cm\uff0c\u517c\u9867\u6539\u5584\u8840\u58d3\u3001\u8840\u8102\u3001\u8840\u5c3f\u9178\u548c\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u591a\u91cd\u4ee3\u8b1d\u6307\u6a19\u3002\u746a\u4ed5\u5ea6\u80bd\u9084\u80fd\u6709\u6548\u964d\u4f4e\u7cd6\u5316\u8840\u7d05\u86cb\u767d\u90542.15%\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002 \u91dd\u5c0d\u9019\u9805\u6700\u65b0\u767c\u5e03\u7684\u91cd\u78c5\u7814\u7a76\uff0c\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\u6ce2\u58eb\u9813\u5e03\u840a\u6839\u5a66\u5973\u91ab\u9662 Vanita R. 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\u53c3\u8003\u6587\u737b           JI L, et al. 1856-LB: Efficacy and Safety of Mazdutide in Chinese Participants with Overweight or Obesity (GLORY-1). Diabetes, 2024, 73(Supplement_1).         \u00a0Mazdutide reduces body weight in adults with overweight or obesity: a multiple-dose study.2024 EASD Abstract # 734.         \u00a0Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol 2021; 9: 373-92.         Institute for Health Metrics and Evaluation. Global Health Data Exchange. 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kg\/m2\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u76f8\u8f03\u5b89\u6170\u5291\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd\u3002 \u57fa\u65bc\u7642\u6548\u4f30\u8a08\u76ee\u6a19\uff1a\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u7684\u5747\u503c\u5206\u5225\u70ba\u221210.97%\u3001\u221213.38%\u548c\u22120.24%\uff1b\u7b2c48\u5468\u6642\u5206\u5225\u70ba\u221212.05%\u3001\u221214.84%\u548c\u22120.47%\u3002\u7b2c32\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u22655%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905476.3%\u300184.0%\u548c10.9%\u3002\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45\u226515%\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u905437.0%\u300150.6%\u548c2.1%\u3002\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\u53ca\u6240\u6709\u95dc\u9375\u6b21\u8981\u7d42\u9ede\u7d50\u679c\u5747\u986f\u793a\u4e86\u746a\u4ed5\u5ea6\u80bd\u4efb\u4e00\u5291\u91cf\u7d44\u76f8\u8f03\u5b89\u6170\u5291\u7d44\u5177\u6709\u7d71\u8a08\u5b78\u610f\u7fa9\u7684\u512a\u6548\u6027\uff0cp\u503c\u5747\u5c0f\u65bc0.001\uff08\u4e3b\u8981\u7d50\u679c\u5982\u4e0b\uff09\u3002 \u7642\u6548\u4f30\u8a08\u76ee\u6a191 \u7642\u6cd5\u4f30\u8a08\u76ee\u6a192 \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202) \u5b89\u6170\u5291\u00a0 (N=205) \u746a\u4ed5\u5ea6\u80bd\u00a04 mg(N=203) \u746a\u4ed5\u5ea6\u80bd\u00a06 mg(N=202) \u5b89\u6170\u5291\u00a0 (N=205) \u4e3b\u8981\u7d42\u9ede\uff0832\u5468\uff09 \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4 \u221210.97% \u221213.38% \u22120.24% \u221210.09% \u221212.55% 0.45\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655% 76.3\u00a0% 84.0\u00a0% 10.9\u00a0% 73.9\u00a0% 82.0\u00a0% 10.5\u00a0% \u90e8\u5206\u95dc\u9375\u6b21\u8981\u7d42\u9ede\uff0848\u5468\uff09 \u9ad4\u91cd\u6e1b\u5c11\u767e\u5206\u6bd4 \u221212.05% \u221214.84% \u22120.47% \u221211.00% \u221214.01% 0.30\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u22655% 73.5\u00a0% 82.8\u00a0% 11.5\u00a0% 71.6\u00a0% 81.6\u00a0% 10.8\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226510% 55.2\u00a0% 67.9\u00a0% 2.9\u00a0% 53.5\u00a0% 66.7\u00a0% 2.6\u00a0% \u5be6\u73fe\u9ad4\u91cd\u964d\u5e45\u226515% 37.0\u00a0% 50.6\u00a0% 2.1\u00a0% 35.7\u00a0% 49.5\u00a0% 2.0\u00a0% \u8170\u570d\u6e1b\u5c11 \u22129.48 cm \u221210.96 cm \u22121.48 cm \u22129.12 cm \u221210.72 cm \u22121.41 cm \u00a0 1\uff1a\u7642\u6548\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u5728\u63d0\u524d\u7d42\u6b62\u7814\u7a76\u7528\u85e5\u6216\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u4e4b\u524d\u7684\u7642\u6548\u3002 2\uff1a\u7642\u6cd5\u4f30\u8a08\u76ee\u6a19\u4ee3\u8868\u7121\u8ad6\u662f\u5426\u5b8c\u6210\u65b9\u6848\u8981\u6c42\u7684\u65e2\u5b9a\u6cbb\u7642\u548c\u662f\u5426\u91c7\u53d6\u91dd\u5c0d\u6e1b\u91cd\u7684\u85e5\u7269\u6cbb\u7642\u548c\u624b\u8853\u7684\u60c5\u6cc1\u4e0b\u7684\u7642\u6548\u3002 \u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u8840\u58d3\u3001\u8840\u8102\uff08\u7518\u6cb9\u4e09\u916f\u3001\u7e3d\u81bd\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff09\u3001\u8840\u5c3f\u9178\u3001\u8f49\u6c28\u9176\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002 \u6b64\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u986f\u8457\u964d\u4f4e\u4e86\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u3002 \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u22655%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221263.26%\u3001\u221273.18%\u548c+8.20%\uff1b \u5728\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u226510%\u7684\u53d7\u8a66\u8005\u4e2d\uff0c\u7b2c48\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd4 mg\u30016 mg\u548c\u5b89\u6170\u5291\u7d44\u53d7\u8a66\u8005\u5168\u809d\u5e73\u5747\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba\u221265.85%\u3001\u221280.24%\u548c\u22125.27%\u3002 \u746a\u4ed5\u5ea6\u80bd\u7e3d\u9ad4\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d\u3002 \u746a\u4ed5\u5ea6\u80bd\u7d44\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5f81\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6GLP-1\u53d7\u9ad4\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u5831\u544a\u7684\u6cbb\u7642\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u60e1\u5fc3\u3001\u8179\u7009\u548c\u5614\u5410\uff0c\u5927\u591a\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\u3002 \u7814\u7a76\u671f\u9593\u672a\u898b\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002 \u8a72\u7814\u7a76\u7684\u727d\u982d\u7814\u7a76\u8005\u3001\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\u8868\u793a\uff1a\u300c\u9577\u671f\u4ee5\u4f86\uff0c\u5168\u7403\u80a5\u80d6\u8a3a\u7642\u6307\u5357\u4e3b\u8981\u57fa\u65bc\u767d\u4eba\u4eba\u7fa4\u6578\u64da\uff0c\u5c0d\u4e9e\u6d32\u4eba\u7fa4\u7684\u9069\u7528\u6027\u5b58\u5728\u504f\u5dee\u3002\u8207\u6b64\u540c\u6642\uff0c\u76f8\u6bd4\u6b50\u7f8e\u4eba\u7fa4\uff0c\u4e2d\u570b\u8d85\u91cd\u80a5\u80d6\u4eba\u7fa4\u6709\u8457\u7368\u7279\u7684\u75be\u75c5\u7279\u9ede\u53ca\u6cbb\u7642\u9700\u6c42\uff0c\u4e9f\u9700\u4ee5\u4e2d\u570b\u8b49\u64da\uff0c\u6307\u5c0e\u4e2d\u570b\u8d85\u91cd\u80a5\u80d6\u4eba\u7fa4\u7684\u9ad4\u91cd\u7ba1\u7406\u3002\u5c0d\u65bc\u4e2d\u570b\u5927\u591a\u6578\u8d85\u91cd\u548c\u8f15\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\uff0c\u6e1b\u91cd\u76ee\u6a19\u61c9\u8a2d\u5b9a\u70ba\uff1a\u57283-6\u500b\u6708\u4e4b\u5167\u81f3\u5c11\u5c07\u9ad4\u91cd\u964d\u4f4e5%-15%\u4e26\u7dad\u6301\uff1b\u5c0d\u65bc\u4e2d\u3001\u91cd\u5ea6\u80a5\u80d6\u75c7\u60a3\u8005\u5247\u53ef\u8a2d\u5b9a\u66f4\u9ad8\u7684\u6e1b\u91cd\u76ee\u6a19\u3002GLORY-1\u7814\u7a76\u4eba\u7fa4\u5168\u90e8\u4f86\u81ea\u4e2d\u570b\u4eba\u7fa4\uff0c\u7b26\u5408\u4e0a\u8ff0\u4e2d\u570b\u4eba\u7fa4\u6e1b\u91cd\u76ee\u6a19\u7684\u8a2d\u5b9a\uff0c\u7814\u7a76\u4e2d\u746a\u4ed5\u5ea6\u80bd\u7684\u6e1b\u91cd\u6578\u64da\u5341\u5206\u4ee4\u4eba\u632f\u596e\uff0c\u8fd1\u534a\u6578\u60a3\u8005\u6e1b\u91cd\u5e45\u5ea6&gt;15%\uff0c\u9019\u63d0\u793a\uff0c\u5c0d\u65bc\u8d85\u91cd\u3001\u8f15\u5ea6\u548c\u4e2d\u91cd\u5ea6\u80a5\u80d6\u60a3\u8005\uff0c\u746a\u4ed5\u5ea6\u80bd\u5747\u80fd\u5920\u5e6b\u52a9\u5176\u986f\u8457\u63a7\u5236\u9ad4\u91cd\uff0c\u5b8c\u6210\u6e1b\u91cd\u76ee\u6a19\u3002\u746a\u4ed5\u5ea6\u80bdGLORY-1\u7814\u7a76\u898b\u520a\u65bc\u5168\u7403\u6700\u6b0a\u5a01\u7684\u81e8\u5e8a\u91ab\u5b78\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\uff0c\u4e0d\u50c5\u4ee3\u8868\u4e86\u4e2d\u570b\u5728\u5167\u5206\u6ccc\u4ee3\u8b1d\u9818\u57df\u7684\u5275\u65b0\u7814\u7a76\u6210\u679c\u5f97\u5230\u4e86\u570b\u969b\u8a8d\u53ef\uff0c\u4e5f\u518d\u6b21\u8b49\u5be6\u4e2d\u570b\u5275\u65b0\u85e5\u7269\u7684\u7814\u767c\u80fd\u529b\u8207\u751f\u7269\u79d1\u6280\u5275\u65b0\u6c34\u5e73\u5df2\u8d70\u5728\u4e86\u5168\u7403\u524d\u5217\u3002\u746a\u4ed5\u5ea6\u80bd\u7684\u7814\u767c\u6210\u529f\u5c07\u52a0\u901f\u672c\u571f\u4f01\u696d\u5728\u80a5\u80d6\u7ba1\u7406\u9818\u57df\u7684\u5e03\u5c40\uff0c\u70ba\u4e2d\u570b\u8d85\u91cd\u80a5\u80d6\u60a3\u8005\u63d0\u4f9b\u66f4\u5177\u500b\u6027\u5316\u7684\u5168\u5468\u671f\u7ba1\u7406\u65b9\u6848\u3002\u300d 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