{"id":313282,"date":"2025-04-16T09:00:00","date_gmt":"2025-04-16T01:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=313282"},"modified":"2025-04-16T09:00:00","modified_gmt":"2025-04-16T01:00:00","slug":"%e3%80%8a%e6%9f%b3%e8%91%89%e5%88%80%e5%85%92%e7%ab%a5%e9%9d%92%e5%b0%91%e5%b9%b4%e5%81%a5%e5%ba%b7%e3%80%8b%e7%99%bc%e8%a1%a8%e9%bd%8a%e7%91%9e%e7%b4%a2%e9%9f%8b%e6%b2%bb%e7%99%826%e5%80%8b","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=313282","title":{"rendered":"\u300a\u67f3\u8449\u5200\u2022\u5152\u7ae5\u9752\u5c11\u5e74\u5065\u5eb7\u300b\u767c\u8868\u9f4a\u745e\u7d22\u97cb\u6cbb\u76426\u500b\u6708\u4ee5\u4e0b\u4f4f\u9662\u5b30\u5152\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u611f\u67d3\u7684\u6700\u65b0\u7814\u7a76\u7d50\u679c"},"content":{"rendered":"
\n\n\n\n
\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4e0a\u6d77<\/span>2025\u5e744\u670816\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — 2025\u5e744\u670816\u65e5\uff0c\u570b\u969b\u5152\u7ae5\u9752\u5c11\u5e74\u5065\u5eb7\u9818\u57df\u7684\u9802\u7d1a\u671f\u520a\u300a\u67f3\u8449\u5200<\/b>\u2022<\/b>\u5152\u7ae5\u9752\u5c11\u5e74\u5065\u5eb7\u300b\uff08<\/b>The Lancet Child & Adolescent Health\uff09<\/b>\u5728\u7dda\u767c\u8868\u4e86\u9996\u500bRSV\u7279\u7570\u6027\u6297\u75c5\u6bd2\u85e5\u7269\u9f4a\u745e\u7d22\u97cb\uff08Ziresovir\uff09\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u6210\u679c\uff0c\u984c\u70ba \u300cEfficacy and safety of ziresovir in hospitalised infants aged 6 months or younger with respiratory syncytial virus infection in China<\/span>: findings from a phase 3 randomised trial with 24-month follow-up\u300d\u3002\u9019\u662f\u7e7c\u8a72\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u57282024\u5e749\u6708\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u5f8c\uff0c\u518d\u6b21\u767b\u4e0a\u5168\u7403\u77e5\u540d\u91ab\u5b78\u671f\u520a\u3002<\/p>\n

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\u56fe\u7247\u6765\u6e90\uff1aThe Lancet Child & Adolescent Health<\/span><\/p>\n<\/p><\/div>\n

RSV\uff1a\u4e9f\u5f85\u89e3\u6c7a\u7684\u91ab\u7642\u9700\u6c42<\/b><\/p>\n

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\u7814\u7a76\u8a2d\u8a08<\/b><\/p>\n

\u8a72\u7814\u7a76\u662f\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5728\u4e2d\u570b28\u5bb6\u91ab\u9662\u768430\u500b\u4e2d\u5fc3\u958b\u5c55\u3002\u7814\u7a76\u5206\u70ba\u5169\u90e8\u5206\uff1a\u7b2c\u4e00\u90e8\u5206\uff08Part 1\uff09\u8a55\u4f30\u5b89\u5168\u6027\uff1b\u7b2c\u4e8c\u90e8\u5206\uff08Part 2\uff09\u9a57\u8b49\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u60a3\u8005\u63092:1\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u9f4a\u745e\u7d22\u97cb\uff08\u6839\u64da\u9ad4\u91cd\u7d66\u85e5\uff1a10\u300120\u300140 mg\uff0c\u6bcf\u65e5\u5169\u6b21\uff09\u6216\u5b89\u6170\u5291\u6cbb\u76425\u5929\uff0c\u4e26\u5b8c\u621024\u500b\u6708\u7684\u96a8\u8a2a\u3002\u672c\u7814\u7a76\u70ba\u5e74\u9f61\u5728\u516d\u500b\u6708\u4ee5\u4e0b\u60a3\u8005\u7684\u4e9e\u7d44\u5206\u6790\u548c24\u500b\u6708\u7684\u96a8\u8a2a\u7d50\u679c\u3002<\/p>\n

\u6838\u5fc3\u7814\u7a76\u7d50\u679c\uff1a <\/b><\/p>\n

1. \u7642\u6548\u986f\u8457\u00a0 <\/b><\/p>\n

\u00a0\u00a0– \u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u986f\u8457\u6539\u5584<\/b>\uff1a\u6cbb\u7642\u7d44\u7b2c3\u5929\u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u81e8\u5e8a\u8a55\u5206\uff08Wang bronchiolitis clinical score\uff0cWBCS\uff09\u8f03\u57fa\u7dda\u4e0b\u964d3.5\u5206\uff08vs. \u5b89\u6170\u5291\u7d442.2\u5206\uff09\uff0c\u5dee\u7570\u905454.5%\uff08p<0.001\uff09\uff0c\u4e14\u547c\u5438\u983b\u7387\u3001\u5598\u606f\u3001\u547c\u5438\u808c\u51f9\u9677\u7b49\u5206\u9805\u8a55\u5206\u5747\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\uff08p<0.05\uff09\u3002\u00a0<\/p>\n

\u00a0 \u00a0– \u75c5\u6bd2\u8f09\u91cf\u5feb\u901f\u4e0b\u964d<\/b>\uff1a\u6cbb\u7642\u7d44\u7b2c5\u5929\u75c5\u6bd2\u8f09\u91cf\u8f03\u57fa\u7dda\u964d\u4f4e2.51 log10<\/sub>\u62f7\u8c9d\/mL\uff08vs. \u5b89\u6170\u5291\u7d441.87 log10<\/sub>\u62f7\u8c9d\/mL\uff09\uff0c\u76f8\u6bd4\u5b89\u6170\u5291\u7d44\u591a\u964d0.64 log10<\/sub>\uff08p=0.024\uff09\uff0c\u63d0\u793a\u9f4a\u745e\u7d22\u97cb\u5177\u6709\u660e\u986f\u7684\u6297\u75c5\u6bd2\u6548\u679c\u3002\u00a0<\/p>\n

\u00a0\u00a0 – \u75c7\u72c0\u7de9\u89e3\u52a0\u901f<\/b>\uff1a\u6cbb\u7642\u7d44\u5598\u606f\u7de9\u89e3\u6642\u9593\uff08HR=1.53, p=0.021\uff09\u8207\u547c\u5438\u808c\u51f9\u9677\u7de9\u89e3\u6642\u9593\uff08HR=1.49, p=0.018\uff09\u986f\u8457\u7e2e\u77ed\uff0c\u4f4f\u9662\u6642\u9577\u8207\u6c27\u7642\u9700\u6c42\u96d6\u7121\u7d71\u8a08\u5b78\u5dee\u7570\uff0c\u4f46\u5448\u73fe\u6539\u5584\u8da8\u52e2\u3002<\/p>\n

2. \u9577\u671f\u5b89\u5168\u6027\u826f\u597d\u53ca\u5598\u606f\u98a8\u96aa\u964d\u4f4e\u00a0 <\/b><\/p>\n

\u00a0\u00a0 – \u5b89\u5168\u6027\u826f\u597d<\/b>\uff1a\u6cbb\u7642\u7d44\u8207\u5b89\u6170\u5291\u7d44\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u767c\u751f\u7387\u5206\u5225\u70ba18% vs. 11%\uff0c\u672a\u767c\u751f\u56b4\u91cd\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u6216\u6b7b\u4ea1\u75c5\u4f8b\u3002\u00a0<\/p>\n

\u00a0\u00a0 – \u5598\u606f\u548c\u54ee\u5598\u767c\u751f\u7387\u986f\u8457\u4e0b\u964d<\/b>\uff1a24\u500b\u6708\u96a8\u8a2a\u986f\u793a\uff0c\u6cbb\u7642\u7d44\u5e74\u5316\u5598\u606f\u767c\u751f\u7387\u8f03\u5b89\u6170\u5291\u7d44\u964d\u4f4e3.6\u500d\uff080.18%vs. 0.65%, p=0.0048\uff09\uff0c\u4e14\u5598\u606f\u767c\u4f5c\u6b21\u6578\u6e1b\u5c112.6\u500d\uff081.2\u6b21 vs. 3.1\u6b21\uff09\u3002\u6b64\u5916\uff0c\u6cbb\u7642\u7d44\u54ee\u5598\u8a3a\u65b7\u7387\uff083%\uff09\u4f4e\u65bc\u5b89\u6170\u5291\u7d44\uff085%\uff09\uff0c\u63d0\u793a\u65e9\u671f\u6297\u75c5\u6bd2\u6cbb\u7642\u53ef\u5c0d\u5152\u7ae5\u9060\u671f\u547c\u5438\u9053\u5065\u5eb7\uff08\u5982\u53cd\u8986\u5598\u606f\u3001\u54ee\u5598\uff09\u7522\u751f\u4fdd\u8b77\u6548\u61c9\u3002<\/p>\n

RSV \u6cbb\u7642\u65b0\u7d00\u5143<\/b><\/p>\n

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\u4eca\u5e743\u6708\uff0c\u5728\u5df4\u897f\u8209\u884c\u7684\u7b2c13\u5c46\u5168\u7403RSV\u5b78\u8853\u96d9\u5e74\u6703\u4e0a\uff0c\u611b\u79d1\u767e\u767cCEO\u9114\u5f81\u535a\u58eb\u901a\u904e\u5927\u6703\u4e3b\u984c\u5831\u544a\u5c55\u793a\u4e86\u9019\u4e00\u539f\u5275\u6210\u679c\uff0c\u5f15\u8d77\u4e86\u570b\u969b\u540c\u884c\u7684\u5ee3\u6cdb\u95dc\u6ce8\u548c\u8a8d\u53ef\u3002\u9f4a\u745e\u7d22\u97cb\u5728\u570b\u969b\u5927\u6703\u7684\u4e00\u6b21\u6b21\u4eae\u76f8\uff0c\u5c55\u73fe\u4e86\u611b\u79d1\u767e\u767c\u548c\u4e2d\u570b\u81e8\u5e8a\u5c08\u5bb6\u5728\u5152\u7ae5\u85e5\u7814\u767c\u9818\u57df\u7684\u5275\u65b0\u5be6\u529b\uff0c\u5f9e\u5be6\u9a57\u5ba4\u5230\u4e16\u754c\u821e\u53f0\u7684\u8de8\u8d8a\uff0c\u70ba\u7834\u89e3\u5168\u7403\u547c\u5438\u9053\u75be\u75c5\u96e3\u984c\u63d0\u4f9b\u4e86\u300c\u4e2d\u570b\u5275\u65b0\u85e5\u300d\uff0c\u5c55\u73fe\u70ba\u5152\u7ae5\u5065\u5eb7\u6210\u9577\u7684\u7684\u79d1\u7814\u64d4\u7576\u3002<\/p>\n

\u9996\u90fd\u91ab\u79d1\u5927\u5b78\u9644\u5c6c\u5317\u4eac\u5152\u7ae5\u91ab\u9662\u9662\u9577\u502a\u946b\u6559\u6388\u8868\u793a\uff1a<\/b><\/p>\n

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https:\/\/www.thelancet.com\/journals\/lanchi\/article\/PIIS2352-4642(25)00067-7\/fulltext<\/a>\u00a0<\/p>\n

\u95dc\u65bc\u9f4a\u745e\u7d22\u97cb<\/b><\/p>\n

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###<\/p>\n

\u95dc\u65bc\u611b\u79d1\u767e\u767c<\/b><\/p>\n

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\u516c\u53f8\u8a73\u60c5\uff0c\u8acb\u8a2a\u554f\u7db2\u7ad9\uff1awww.arkbiosciences.com<\/a><\/p>\n

\u6295\u8cc7\u8005\u5782\u8a62\uff1aIR@arkbiosciences.com<\/a><\/p>\n

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log10\uff08p=0.024\uff09\uff0c\u63d0\u793a\u9f4a\u745e\u7d22\u97cb\u5177\u6709\u660e\u986f\u7684\u6297\u75c5\u6bd2\u6548\u679c\u3002\u00a0 \u00a0\u00a0 - \u75c7\u72c0\u7de9\u89e3\u52a0\u901f\uff1a\u6cbb\u7642\u7d44\u5598\u606f\u7de9\u89e3\u6642\u9593\uff08HR=1.53, p=0.021\uff09\u8207\u547c\u5438\u808c\u51f9\u9677\u7de9\u89e3\u6642\u9593\uff08HR=1.49, p=0.018\uff09\u986f\u8457\u7e2e\u77ed\uff0c\u4f4f\u9662\u6642\u9577\u8207\u6c27\u7642\u9700\u6c42\u96d6\u7121\u7d71\u8a08\u5b78\u5dee\u7570\uff0c\u4f46\u5448\u73fe\u6539\u5584\u8da8\u52e2\u3002 2. \u9577\u671f\u5b89\u5168\u6027\u826f\u597d\u53ca\u5598\u606f\u98a8\u96aa\u964d\u4f4e\u00a0 \u00a0\u00a0 - \u5b89\u5168\u6027\u826f\u597d\uff1a\u6cbb\u7642\u7d44\u8207\u5b89\u6170\u5291\u7d44\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u767c\u751f\u7387\u5206\u5225\u70ba18% vs. 11%\uff0c\u672a\u767c\u751f\u56b4\u91cd\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u6216\u6b7b\u4ea1\u75c5\u4f8b\u3002\u00a0 \u00a0\u00a0 - 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\u662f\u5168\u7403\u7bc4\u570d\u5167\u9996\u6b3e\u5b8c\u6210III\u671f\u81e8\u5e8a\u8a66\u9a57\u4e26\u53d6\u5f97\u7a4d\u6975\u7d50\u679c\u7684\u9776\u5411RSV\u7279\u6548\u6297\u75c5\u6bd2\u85e5\u7269\uff0c\u4e5f\u662f\u9996\u500b\u7d0d\u5165\u570b\u5bb6\u7a81\u7834\u6027\u6cbb\u7642\u54c1\u7a2e\u7684\u975e\u816b\u7624\u65b0\u85e5\u3002\u53e6\u4e00\u500b\u63a5\u8fd1\u5546\u696d\u5316\u7684\u7522\u54c1\u662f\u5df2\u7372\u5f97FDA\u6279\u51c6\u7684\u5152\u7ae5\u591a\u52d5\u75c7\u65b0\u85e5AK0901\uff08\u611b\u667a\u9054\u2122\uff09\uff0c\u611b\u79d1\u767e\u767c\u64c1\u6709\u5176\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u548c\u71df\u92b7\u6b0a\u3002\u516c\u53f8\u9084\u64c1\u6709\u591a\u500b\u5177\u6709\u540c\u985e\u6700\u4f73\u6216\u540c\u985e\u9996\u5275\u6f5b\u529b\u7684\u65b0\u85e5\u6b63\u8655\u65bc\u81e8\u5e8a\u8a66\u9a57\u958b\u767c\u968e\u6bb5\u3002 \u611b\u79d1\u767e\u767c\u8207\u7f85\u6c0f\/\u57fa\u56e0\u6cf0\u514b\u7b49\u8de8\u570b\u85e5\u4f01\u3001\u7f8e\u570b\u5b78\u8853\u6a5f\u69cbScripps\u7814\u7a76\u6240\u3001\u4e2d\u570b\u79d1\u5b78\u9662\u5fae\u751f\u7269\u7814\u7a76\u6240\u3001\u570b\u5167\u5916\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u53caCRO\u5efa\u7acb\u4e86\u6230\u7565\u5408\u4f5c\u95dc\u4fc2\u3002\u202f \u516c\u53f8\u8a73\u60c5\uff0c\u8acb\u8a2a\u554f\u7db2\u7ad9\uff1awww.arkbiosciences.com \u6295\u8cc7\u8005\u5782\u8a62\uff1aIR@arkbiosciences.com\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=313282\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u300a\u67f3\u8449\u5200\u2022\u5152\u7ae5\u9752\u5c11\u5e74\u5065\u5eb7\u300b\u767c\u8868\u9f4a\u745e\u7d22\u97cb\u6cbb\u76426\u500b\u6708\u4ee5\u4e0b\u4f4f\u9662\u5b30\u5152\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u611f\u67d3\u7684\u6700\u65b0\u7814\u7a76\u7d50\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u4e0a\u6d772025\u5e744\u670816\u65e5 \/\u7f8e\u901a\u793e\/ -- 2025\u5e744\u670816\u65e5\uff0c\u570b\u969b\u5152\u7ae5\u9752\u5c11\u5e74\u5065\u5eb7\u9818\u57df\u7684\u9802\u7d1a\u671f\u520a\u300a\u67f3\u8449\u5200\u2022\u5152\u7ae5\u9752\u5c11\u5e74\u5065\u5eb7\u300b\uff08The Lancet Child & Adolescent Health\uff09\u5728\u7dda\u767c\u8868\u4e86\u9996\u500bRSV\u7279\u7570\u6027\u6297\u75c5\u6bd2\u85e5\u7269\u9f4a\u745e\u7d22\u97cb\uff08Ziresovir\uff09\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u6210\u679c\uff0c\u984c\u70ba \u300cEfficacy and safety of ziresovir in hospitalised infants aged 6 months or younger with respiratory syncytial virus infection in China: findings from a phase 3 randomised trial with 24-month follow-up\u300d\u3002\u9019\u662f\u7e7c\u8a72\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u57282024\u5e749\u6708\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u5f8c\uff0c\u518d\u6b21\u767b\u4e0a\u5168\u7403\u77e5\u540d\u91ab\u5b78\u671f\u520a\u3002 \u56fe\u7247\u6765\u6e90\uff1aThe Lancet Child & Adolescent Health RSV\uff1a\u4e9f\u5f85\u89e3\u6c7a\u7684\u91ab\u7642\u9700\u6c42 \u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\uff08RSV\uff09\u611f\u67d3\u5728\u5b30\u5e7c\u5152\u5065\u5eb7\u9818\u57df\uff0c\u582a\u7a31 \u300c\u96b1\u533f\u7684\u6bba\u624b\u300d\uff0c\u662f\u5b30\u5e7c\u5152\u4f4f\u9662\u548c\u6b7b\u4ea1\u7684\u6700\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\u3002\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u6bcf\u5e74\u6709\u5927\u91cf\u5b30\u5e7c\u5152\u56e0 RSV \u611f\u67d3\u800c\u906d\u53d7\u75c5\u75db\u6298\u78e8\uff0c\u7d66\u5bb6\u5ead\u548c\u793e\u6703\u5e36\u4f86\u6c89\u91cd\u7684\u8ca0\u64d4\u3002\u76ee\u524d\uff0c\u91dd\u5c0d RSV \u611f\u67d3\u7684\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u4e3b\u8981\u4ee5\u5c0d\u75c7\u8f14\u52a9\u6027\u652f\u6301\u6cbb\u7642\u70ba\u4e3b\uff0c\u7f3a\u4e4f\u7279\u6548\u6297\u75c5\u6bd2\u85e5\u7269\u3002\u9019\u610f\u5473\u8457\u5728\u9762\u5c0dRSV \u611f\u67d3\u6642\uff0c\u91ab\u751f\u5011\u5e38\u5e38\u53ea\u80fd\u901a\u904e\u7de9\u89e3\u75c7\u72c0\u4f86\u5e6b\u52a9\u60a3\u5152\uff0c\u7121\u6cd5\u5f9e\u6839\u672c\u4e0a\u5c0d\u6297\u75c5\u6bd2\u3002\u5c24\u5176\u662f 6\u500b\u6708\u4ee5\u4e0b\u5b30\u5152\uff0c\u56e0\u514d\u75ab\u7cfb\u7d71\u53ca\u547c\u5438\u9053\u767c\u80b2\u4e0d\u6210\u719f\uff0c\u611f\u67d3\u5f8c\u6613\u767c\u5c55\u70ba\u91cd\u75c7\uff0c\u4f4f\u9662\u7387\u548c\u91cd\u75c7\u76e3\u8b77\u9700\u6c42\u986f\u8457\u9ad8\u65bc\u5176\u4ed6\u5e74\u9f61\u6bb5\u3002\u56e0\u6b64\uff0c\u91dd\u5c0d\u9ad8\u5371\u5b30\u5152\u7fa4\u9ad4RSV\u611f\u67d3\u7684\u6709\u6548\u7642\u6cd5\u958b\u767c\u8feb\u5728\u7709\u776b\u3002\u57fa\u65bc\u4ee5\u4e0a\u80cc\u666f\uff0c\u9f4a\u745e\u7d22\u97cb\u7684III\u671f\u7814\u7a76\uff0c\u9996\u6b21\u5728\u22646\u500b\u6708\u4f4f\u9662\u5b30\u5152\u4e2d\u9a57\u8b49\u4e86\u9f4a\u745e\u7d22\u97cb\u7684\u81e8\u5e8a\u7642\u6548\uff0c\u4e26\u63ed\u793a\u4e86\u5176\u6e1b\u5c11\u518d\u767c\u5598\u606f\u548c\u54ee\u5598\u7684\u9577\u671f\u7372\u76ca\u3002 \u7814\u7a76\u8a2d\u8a08 \u8a72\u7814\u7a76\u662f\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5728\u4e2d\u570b28\u5bb6\u91ab\u9662\u768430\u500b\u4e2d\u5fc3\u958b\u5c55\u3002\u7814\u7a76\u5206\u70ba\u5169\u90e8\u5206\uff1a\u7b2c\u4e00\u90e8\u5206\uff08Part 1\uff09\u8a55\u4f30\u5b89\u5168\u6027\uff1b\u7b2c\u4e8c\u90e8\u5206\uff08Part 2\uff09\u9a57\u8b49\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u60a3\u8005\u63092:1\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u9f4a\u745e\u7d22\u97cb\uff08\u6839\u64da\u9ad4\u91cd\u7d66\u85e5\uff1a10\u300120\u300140 mg\uff0c\u6bcf\u65e5\u5169\u6b21\uff09\u6216\u5b89\u6170\u5291\u6cbb\u76425\u5929\uff0c\u4e26\u5b8c\u621024\u500b\u6708\u7684\u96a8\u8a2a\u3002\u672c\u7814\u7a76\u70ba\u5e74\u9f61\u5728\u516d\u500b\u6708\u4ee5\u4e0b\u60a3\u8005\u7684\u4e9e\u7d44\u5206\u6790\u548c24\u500b\u6708\u7684\u96a8\u8a2a\u7d50\u679c\u3002 \u6838\u5fc3\u7814\u7a76\u7d50\u679c\uff1a 1. \u7642\u6548\u986f\u8457\u00a0 \u00a0\u00a0- \u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u986f\u8457\u6539\u5584\uff1a\u6cbb\u7642\u7d44\u7b2c3\u5929\u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u81e8\u5e8a\u8a55\u5206\uff08Wang bronchiolitis clinical score\uff0cWBCS\uff09\u8f03\u57fa\u7dda\u4e0b\u964d3.5\u5206\uff08vs. \u5b89\u6170\u5291\u7d442.2\u5206\uff09\uff0c\u5dee\u7570\u905454.5%\uff08p<0.001\uff09\uff0c\u4e14\u547c\u5438\u983b\u7387\u3001\u5598\u606f\u3001\u547c\u5438\u808c\u51f9\u9677\u7b49\u5206\u9805\u8a55\u5206\u5747\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\uff08p<0.05\uff09\u3002\u00a0 \u00a0 \u00a0- \u75c5\u6bd2\u8f09\u91cf\u5feb\u901f\u4e0b\u964d\uff1a\u6cbb\u7642\u7d44\u7b2c5\u5929\u75c5\u6bd2\u8f09\u91cf\u8f03\u57fa\u7dda\u964d\u4f4e2.51 log10\u62f7\u8c9d\/mL\uff08vs. \u5b89\u6170\u5291\u7d441.87 log10\u62f7\u8c9d\/mL\uff09\uff0c\u76f8\u6bd4\u5b89\u6170\u5291\u7d44\u591a\u964d0.64 log10\uff08p=0.024\uff09\uff0c\u63d0\u793a\u9f4a\u745e\u7d22\u97cb\u5177\u6709\u660e\u986f\u7684\u6297\u75c5\u6bd2\u6548\u679c\u3002\u00a0 \u00a0\u00a0 - \u75c7\u72c0\u7de9\u89e3\u52a0\u901f\uff1a\u6cbb\u7642\u7d44\u5598\u606f\u7de9\u89e3\u6642\u9593\uff08HR=1.53, p=0.021\uff09\u8207\u547c\u5438\u808c\u51f9\u9677\u7de9\u89e3\u6642\u9593\uff08HR=1.49, p=0.018\uff09\u986f\u8457\u7e2e\u77ed\uff0c\u4f4f\u9662\u6642\u9577\u8207\u6c27\u7642\u9700\u6c42\u96d6\u7121\u7d71\u8a08\u5b78\u5dee\u7570\uff0c\u4f46\u5448\u73fe\u6539\u5584\u8da8\u52e2\u3002 2. \u9577\u671f\u5b89\u5168\u6027\u826f\u597d\u53ca\u5598\u606f\u98a8\u96aa\u964d\u4f4e\u00a0 \u00a0\u00a0 - \u5b89\u5168\u6027\u826f\u597d\uff1a\u6cbb\u7642\u7d44\u8207\u5b89\u6170\u5291\u7d44\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u767c\u751f\u7387\u5206\u5225\u70ba18% vs. 11%\uff0c\u672a\u767c\u751f\u56b4\u91cd\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u6216\u6b7b\u4ea1\u75c5\u4f8b\u3002\u00a0 \u00a0\u00a0 - \u5598\u606f\u548c\u54ee\u5598\u767c\u751f\u7387\u986f\u8457\u4e0b\u964d\uff1a24\u500b\u6708\u96a8\u8a2a\u986f\u793a\uff0c\u6cbb\u7642\u7d44\u5e74\u5316\u5598\u606f\u767c\u751f\u7387\u8f03\u5b89\u6170\u5291\u7d44\u964d\u4f4e3.6\u500d\uff080.18%vs. 0.65%, p=0.0048\uff09\uff0c\u4e14\u5598\u606f\u767c\u4f5c\u6b21\u6578\u6e1b\u5c112.6\u500d\uff081.2\u6b21 vs. 3.1\u6b21\uff09\u3002\u6b64\u5916\uff0c\u6cbb\u7642\u7d44\u54ee\u5598\u8a3a\u65b7\u7387\uff083%\uff09\u4f4e\u65bc\u5b89\u6170\u5291\u7d44\uff085%\uff09\uff0c\u63d0\u793a\u65e9\u671f\u6297\u75c5\u6bd2\u6cbb\u7642\u53ef\u5c0d\u5152\u7ae5\u9060\u671f\u547c\u5438\u9053\u5065\u5eb7\uff08\u5982\u53cd\u8986\u5598\u606f\u3001\u54ee\u5598\uff09\u7522\u751f\u4fdd\u8b77\u6548\u61c9\u3002 RSV \u6cbb\u7642\u65b0\u7d00\u5143 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Health\uff09\u5728\u7dda\u767c\u8868\u4e86\u9996\u500bRSV\u7279\u7570\u6027\u6297\u75c5\u6bd2\u85e5\u7269\u9f4a\u745e\u7d22\u97cb\uff08Ziresovir\uff09\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u6210\u679c\uff0c\u984c\u70ba \u300cEfficacy and safety of ziresovir in hospitalised infants aged 6 months or younger with respiratory syncytial virus infection in China: findings from a phase 3 randomised trial with 24-month follow-up\u300d\u3002\u9019\u662f\u7e7c\u8a72\u9805III\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u57282024\u5e749\u6708\u767c\u8868\u65bc\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u5f8c\uff0c\u518d\u6b21\u767b\u4e0a\u5168\u7403\u77e5\u540d\u91ab\u5b78\u671f\u520a\u3002 \u56fe\u7247\u6765\u6e90\uff1aThe Lancet Child & Adolescent Health RSV\uff1a\u4e9f\u5f85\u89e3\u6c7a\u7684\u91ab\u7642\u9700\u6c42 \u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\uff08RSV\uff09\u611f\u67d3\u5728\u5b30\u5e7c\u5152\u5065\u5eb7\u9818\u57df\uff0c\u582a\u7a31 \u300c\u96b1\u533f\u7684\u6bba\u624b\u300d\uff0c\u662f\u5b30\u5e7c\u5152\u4f4f\u9662\u548c\u6b7b\u4ea1\u7684\u6700\u91cd\u8981\u56e0\u7d20\u4e4b\u4e00\u3002\u5728\u5168\u7403\u7bc4\u570d\u5167\uff0c\u6bcf\u5e74\u6709\u5927\u91cf\u5b30\u5e7c\u5152\u56e0 RSV \u611f\u67d3\u800c\u906d\u53d7\u75c5\u75db\u6298\u78e8\uff0c\u7d66\u5bb6\u5ead\u548c\u793e\u6703\u5e36\u4f86\u6c89\u91cd\u7684\u8ca0\u64d4\u3002\u76ee\u524d\uff0c\u91dd\u5c0d RSV \u611f\u67d3\u7684\u6cbb\u7642\u624b\u6bb5\u5341\u5206\u6709\u9650\uff0c\u4e3b\u8981\u4ee5\u5c0d\u75c7\u8f14\u52a9\u6027\u652f\u6301\u6cbb\u7642\u70ba\u4e3b\uff0c\u7f3a\u4e4f\u7279\u6548\u6297\u75c5\u6bd2\u85e5\u7269\u3002\u9019\u610f\u5473\u8457\u5728\u9762\u5c0dRSV \u611f\u67d3\u6642\uff0c\u91ab\u751f\u5011\u5e38\u5e38\u53ea\u80fd\u901a\u904e\u7de9\u89e3\u75c7\u72c0\u4f86\u5e6b\u52a9\u60a3\u5152\uff0c\u7121\u6cd5\u5f9e\u6839\u672c\u4e0a\u5c0d\u6297\u75c5\u6bd2\u3002\u5c24\u5176\u662f 6\u500b\u6708\u4ee5\u4e0b\u5b30\u5152\uff0c\u56e0\u514d\u75ab\u7cfb\u7d71\u53ca\u547c\u5438\u9053\u767c\u80b2\u4e0d\u6210\u719f\uff0c\u611f\u67d3\u5f8c\u6613\u767c\u5c55\u70ba\u91cd\u75c7\uff0c\u4f4f\u9662\u7387\u548c\u91cd\u75c7\u76e3\u8b77\u9700\u6c42\u986f\u8457\u9ad8\u65bc\u5176\u4ed6\u5e74\u9f61\u6bb5\u3002\u56e0\u6b64\uff0c\u91dd\u5c0d\u9ad8\u5371\u5b30\u5152\u7fa4\u9ad4RSV\u611f\u67d3\u7684\u6709\u6548\u7642\u6cd5\u958b\u767c\u8feb\u5728\u7709\u776b\u3002\u57fa\u65bc\u4ee5\u4e0a\u80cc\u666f\uff0c\u9f4a\u745e\u7d22\u97cb\u7684III\u671f\u7814\u7a76\uff0c\u9996\u6b21\u5728\u22646\u500b\u6708\u4f4f\u9662\u5b30\u5152\u4e2d\u9a57\u8b49\u4e86\u9f4a\u745e\u7d22\u97cb\u7684\u81e8\u5e8a\u7642\u6548\uff0c\u4e26\u63ed\u793a\u4e86\u5176\u6e1b\u5c11\u518d\u767c\u5598\u606f\u548c\u54ee\u5598\u7684\u9577\u671f\u7372\u76ca\u3002 \u7814\u7a76\u8a2d\u8a08 \u8a72\u7814\u7a76\u662f\u591a\u4e2d\u5fc3\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684III\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u5728\u4e2d\u570b28\u5bb6\u91ab\u9662\u768430\u500b\u4e2d\u5fc3\u958b\u5c55\u3002\u7814\u7a76\u5206\u70ba\u5169\u90e8\u5206\uff1a\u7b2c\u4e00\u90e8\u5206\uff08Part 1\uff09\u8a55\u4f30\u5b89\u5168\u6027\uff1b\u7b2c\u4e8c\u90e8\u5206\uff08Part 2\uff09\u9a57\u8b49\u7642\u6548\u8207\u5b89\u5168\u6027\u3002\u60a3\u8005\u63092:1\u6bd4\u4f8b\u96a8\u6a5f\u63a5\u53d7\u9f4a\u745e\u7d22\u97cb\uff08\u6839\u64da\u9ad4\u91cd\u7d66\u85e5\uff1a10\u300120\u300140 mg\uff0c\u6bcf\u65e5\u5169\u6b21\uff09\u6216\u5b89\u6170\u5291\u6cbb\u76425\u5929\uff0c\u4e26\u5b8c\u621024\u500b\u6708\u7684\u96a8\u8a2a\u3002\u672c\u7814\u7a76\u70ba\u5e74\u9f61\u5728\u516d\u500b\u6708\u4ee5\u4e0b\u60a3\u8005\u7684\u4e9e\u7d44\u5206\u6790\u548c24\u500b\u6708\u7684\u96a8\u8a2a\u7d50\u679c\u3002 \u6838\u5fc3\u7814\u7a76\u7d50\u679c\uff1a 1. \u7642\u6548\u986f\u8457\u00a0 \u00a0\u00a0- \u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u986f\u8457\u6539\u5584\uff1a\u6cbb\u7642\u7d44\u7b2c3\u5929\u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u81e8\u5e8a\u8a55\u5206\uff08Wang bronchiolitis clinical score\uff0cWBCS\uff09\u8f03\u57fa\u7dda\u4e0b\u964d3.5\u5206\uff08vs. \u5b89\u6170\u5291\u7d442.2\u5206\uff09\uff0c\u5dee\u7570\u905454.5%\uff08p<0.001\uff09\uff0c\u4e14\u547c\u5438\u983b\u7387\u3001\u5598\u606f\u3001\u547c\u5438\u808c\u51f9\u9677\u7b49\u5206\u9805\u8a55\u5206\u5747\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\uff08p<0.05\uff09\u3002\u00a0 \u00a0 \u00a0- \u75c5\u6bd2\u8f09\u91cf\u5feb\u901f\u4e0b\u964d\uff1a\u6cbb\u7642\u7d44\u7b2c5\u5929\u75c5\u6bd2\u8f09\u91cf\u8f03\u57fa\u7dda\u964d\u4f4e2.51 log10\u62f7\u8c9d\\\/mL\uff08vs. \u5b89\u6170\u5291\u7d441.87 log10\u62f7\u8c9d\\\/mL\uff09\uff0c\u76f8\u6bd4\u5b89\u6170\u5291\u7d44\u591a\u964d0.64 log10\uff08p=0.024\uff09\uff0c\u63d0\u793a\u9f4a\u745e\u7d22\u97cb\u5177\u6709\u660e\u986f\u7684\u6297\u75c5\u6bd2\u6548\u679c\u3002\u00a0 \u00a0\u00a0 - \u75c7\u72c0\u7de9\u89e3\u52a0\u901f\uff1a\u6cbb\u7642\u7d44\u5598\u606f\u7de9\u89e3\u6642\u9593\uff08HR=1.53, p=0.021\uff09\u8207\u547c\u5438\u808c\u51f9\u9677\u7de9\u89e3\u6642\u9593\uff08HR=1.49, p=0.018\uff09\u986f\u8457\u7e2e\u77ed\uff0c\u4f4f\u9662\u6642\u9577\u8207\u6c27\u7642\u9700\u6c42\u96d6\u7121\u7d71\u8a08\u5b78\u5dee\u7570\uff0c\u4f46\u5448\u73fe\u6539\u5584\u8da8\u52e2\u3002 2. \u9577\u671f\u5b89\u5168\u6027\u826f\u597d\u53ca\u5598\u606f\u98a8\u96aa\u964d\u4f4e\u00a0 \u00a0\u00a0 - \u5b89\u5168\u6027\u826f\u597d\uff1a\u6cbb\u7642\u7d44\u8207\u5b89\u6170\u5291\u7d44\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u767c\u751f\u7387\u5206\u5225\u70ba18% vs. 11%\uff0c\u672a\u767c\u751f\u56b4\u91cd\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u6216\u6b7b\u4ea1\u75c5\u4f8b\u3002\u00a0 \u00a0\u00a0 - \u5598\u606f\u548c\u54ee\u5598\u767c\u751f\u7387\u986f\u8457\u4e0b\u964d\uff1a24\u500b\u6708\u96a8\u8a2a\u986f\u793a\uff0c\u6cbb\u7642\u7d44\u5e74\u5316\u5598\u606f\u767c\u751f\u7387\u8f03\u5b89\u6170\u5291\u7d44\u964d\u4f4e3.6\u500d\uff080.18%vs. 0.65%, p=0.0048\uff09\uff0c\u4e14\u5598\u606f\u767c\u4f5c\u6b21\u6578\u6e1b\u5c112.6\u500d\uff081.2\u6b21 vs. 3.1\u6b21\uff09\u3002\u6b64\u5916\uff0c\u6cbb\u7642\u7d44\u54ee\u5598\u8a3a\u65b7\u7387\uff083%\uff09\u4f4e\u65bc\u5b89\u6170\u5291\u7d44\uff085%\uff09\uff0c\u63d0\u793a\u65e9\u671f\u6297\u75c5\u6bd2\u6cbb\u7642\u53ef\u5c0d\u5152\u7ae5\u9060\u671f\u547c\u5438\u9053\u5065\u5eb7\uff08\u5982\u53cd\u8986\u5598\u606f\u3001\u54ee\u5598\uff09\u7522\u751f\u4fdd\u8b77\u6548\u61c9\u3002 RSV \u6cbb\u7642\u65b0\u7d00\u5143 \u7576\u524dRSV\u611f\u67d3\u6cbb\u7642\u4ee5\u63a7\u5236\u75c7\u72c0\u70ba\u4e3b\uff0c\u9f4a\u745e\u7d22\u97cb\u7684\u7642\u6548\u70ba\u81e8\u5e8a\u63d0\u4f9b\u4e86\u9996\u500b\u7279\u7570\u6027\u6297\u75c5\u6bd2\u85e5\u7269\u9078\u64c7\u3002\u5c24\u5176\u5c0d\u65bc\u22646\u500b\u6708\u5b30\u5152\uff0c\u7531\u65bc\u5176\u91cd\u75c7\u98a8\u96aa\u9ad8\u3001\u514d\u75ab\u529b\u4f4e\uff0c\u9078\u64c7\u9f4a\u745e\u7d22\u97cb\u5feb\u901f\u964d\u4f4e\u75c5\u6bd2\u8f09\u91cf\u53ef\u6709\u6548\u904f\u5236\u75c5\u60c5\u9032\u5c55\u3002\u540c\u6642\u672c\u8a66\u9a57\u9996\u6b21\u901a\u904e\u9577\u671f\u96a8\u8a2a\u8b49\u660e\uff0c\u9f4a\u745e\u7d22\u97cb\u53ef\u964d\u4f4e\u5598\u606f\u767c\u751f\u7684\u76f8\u95dc\u98a8\u96aa\uff0c\u5176\u6a5f\u5236\u53ef\u80fd\u8207\u75c5\u6bd2\u8f09\u91cf\u63a7\u5236\u53ca\u708e\u75c7\u53cd\u61c9\u6e1b\u8f15\u6709\u95dc\u3002\u9019\u4e00\u767c\u73fe\u4e0d\u50c5\u62d3\u5c55\u4e86\u6297\u75c5\u6bd2\u85e5\u7269\u7684\u81e8\u5e8a\u50f9\u503c\uff0c\u4e5f\u70baRSV\u76f8\u95dc\u6162\u6027\u547c\u5438\u75be\u75c5\u7684\u9632\u6cbb\u7b56\u7565\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002 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\u7642\u6548\u986f\u8457\u00a0 \u00a0\u00a0- \u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u986f\u8457\u6539\u5584\uff1a\u6cbb\u7642\u7d44\u7b2c3\u5929\u6bdb\u7d30\u652f\u6c23\u7ba1\u708e\u81e8\u5e8a\u8a55\u5206\uff08Wang bronchiolitis clinical score\uff0cWBCS\uff09\u8f03\u57fa\u7dda\u4e0b\u964d3.5\u5206\uff08vs. \u5b89\u6170\u5291\u7d442.2\u5206\uff09\uff0c\u5dee\u7570\u905454.5%\uff08p<0.001\uff09\uff0c\u4e14\u547c\u5438\u983b\u7387\u3001\u5598\u606f\u3001\u547c\u5438\u808c\u51f9\u9677\u7b49\u5206\u9805\u8a55\u5206\u5747\u986f\u8457\u512a\u65bc\u5b89\u6170\u5291\uff08p<0.05\uff09\u3002\u00a0 \u00a0 \u00a0- \u75c5\u6bd2\u8f09\u91cf\u5feb\u901f\u4e0b\u964d\uff1a\u6cbb\u7642\u7d44\u7b2c5\u5929\u75c5\u6bd2\u8f09\u91cf\u8f03\u57fa\u7dda\u964d\u4f4e2.51 log10\u62f7\u8c9d\/mL\uff08vs. \u5b89\u6170\u5291\u7d441.87 log10\u62f7\u8c9d\/mL\uff09\uff0c\u76f8\u6bd4\u5b89\u6170\u5291\u7d44\u591a\u964d0.64 log10\uff08p=0.024\uff09\uff0c\u63d0\u793a\u9f4a\u745e\u7d22\u97cb\u5177\u6709\u660e\u986f\u7684\u6297\u75c5\u6bd2\u6548\u679c\u3002\u00a0 \u00a0\u00a0 - \u75c7\u72c0\u7de9\u89e3\u52a0\u901f\uff1a\u6cbb\u7642\u7d44\u5598\u606f\u7de9\u89e3\u6642\u9593\uff08HR=1.53, p=0.021\uff09\u8207\u547c\u5438\u808c\u51f9\u9677\u7de9\u89e3\u6642\u9593\uff08HR=1.49, p=0.018\uff09\u986f\u8457\u7e2e\u77ed\uff0c\u4f4f\u9662\u6642\u9577\u8207\u6c27\u7642\u9700\u6c42\u96d6\u7121\u7d71\u8a08\u5b78\u5dee\u7570\uff0c\u4f46\u5448\u73fe\u6539\u5584\u8da8\u52e2\u3002 2. \u9577\u671f\u5b89\u5168\u6027\u826f\u597d\u53ca\u5598\u606f\u98a8\u96aa\u964d\u4f4e\u00a0 \u00a0\u00a0 - \u5b89\u5168\u6027\u826f\u597d\uff1a\u6cbb\u7642\u7d44\u8207\u5b89\u6170\u5291\u7d44\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TEAEs\uff09\u767c\u751f\u7387\u5206\u5225\u70ba18% vs. 11%\uff0c\u672a\u767c\u751f\u56b4\u91cd\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u6216\u6b7b\u4ea1\u75c5\u4f8b\u3002\u00a0 \u00a0\u00a0 - 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