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PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u9ad4\u914d\u9ad41\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u555f\u52d5\u6dcb\u5df4\u7d30\u80de\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5f9e\u800c\u9054\u5230\u6cbb\u7642\u816b\u7624\u7684\u76ee\u7684<sup>4<\/sup>\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u7372\u6279\u4e26\u7d0d\u5165\u65b0\u7248\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\u4e03\u9805\u9069\u61c9\u75c7\uff0c\u5354\u8b70\u671f\u5167\u91ab\u4fdd\u76ee\u9304\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u7bc4\u570d\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u81f3\u5c11\u7d93\u904e\u4e8c\u7dda\u7cfb\u7d71\u5316\u7642\u7684\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u7d93\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7642\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\uff08EGFR\uff09\u57fa\u56e0\u7a81\u8b8a\u9670\u6027\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176(ALK)\u9670\u6027\u3001 \u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08EGFR-TKI\uff09 \u6cbb\u7642\u5931\u6557\u7684 EGFR \u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u7684\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u809d\u7d30\u80de\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<p>\u6b64\u5916\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u7684\u7b2c\u516b\u9805\u9069\u61c9\u75c7\uff0c\u5373\u8207\u592b\u594e\u66ff\u5c3c\u7684\u806f\u5408\u7642\u6cd5\u7528\u65bc\u6cbb\u7642\u65e2\u5f80\u7cfb\u7d71\u6027\u6297\u816b\u7624\u6cbb\u7642\u5f8c\u5931\u6557\u4e14\u4e0d\u9069\u5408\u9032\u884c\u6839\u6cbb\u6027\u624b\u8853\u6cbb\u7642\u6216\u6839\u6cbb\u6027\u653e\u7642\u7684\u665a\u671f\u932f\u914d\u4fee\u5fa9\u5b8c\u6574\uff08pMMR\uff09\u7684\u5b50\u5bae\u5167\u819c\u764c\u60a3\u8005\u7684NDA\u5df2\u65bc2024\u5e7412\u6708\u53d6\u5f97NMPA\u9644\u689d\u4ef6\u6279\u51c6\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u7684\u7b2c\u4e5d\u9805\u9069\u61c9\u75c7\uff0c\u5373\u806f\u5408\u4f0a\u5339\u6728\u55ae\u6297\u7528\u65bc\u53ef\u5207\u9664\u7684MSI-H\/dMMR\u7d50\u8178\u764c\u60a3\u8005\u7684\u65b0\u8f14\u52a9\u6cbb\u7642\u7684NDA\u5728NMPA\u512a\u5148\u5be9\u8a55\u4e2d\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\u53e6\u6709\u5169\u9805\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u7814\u7a76\u7d42\u9ede\uff0c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u55ae\u85e5\u7528\u65bc\u665a\u671f\/\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u4e8c\u7dda\u6cbb\u7642\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\uff1b<\/li>\n<li>\u55ae\u85e5\u7528\u65bc\u542b\u9251\u5316\u7642\u5931\u6557\u7684\u665a\u671f\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u4e8c\u7dda\u6cbb\u7642\u7684III\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/li>\n<\/ul>\n<p><b>\u95dc\u65bc\u4fe1\u9054\u751f\u7269<\/b><\/p>\n<p>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc2011\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u670914\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<sup>\u00ae<\/sup>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<sup>\u00ae<\/sup>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<sup>\u00ae<\/sup>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<sup>\u00ae<\/sup>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<sup>\u00ae<\/sup>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<sup>\u00ae<\/sup>\uff09\uff0c 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href=\"https:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow 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\u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<p>\u53c3\u8003\u6587\u737b<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">1.\u00a0\u00a0\u00a0\u00a0 <a href=\"http:\/\/abstracts.asco.org\/239\/AbstView_239_267235.html\" target=\"_blank\" class=\"prnews_a\" rel=\"nofollow noopener\">http:\/\/abstracts.asco.org\/239\/AbstView_239_267235.html<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">2.\u00a0\u00a0\u00a0 Morton D, et al; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. DOI: 10.1200\/JCO.22.00046.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">3.\u00a0\u00a0\u00a0 Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. DOI:10.1634\/theoncologist.13-S4-2<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">4.\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. DOI: 10.1080\/19420862.2019.1654303.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[1] \u00a0\u00a0\u6839\u64daNMPA 2020\u5e747\u67081\u65e5\u65bd\u884c\u7684\u300a\u85e5\u54c1\u6ce8\u518a\u7ba1\u7406\u8fa6\u6cd5\u300b\uff08\u570b\u5bb6\u5e02\u5834\u76e3\u7763\u7ba1\u7406\u7e3d\u5c40\u4ee4\u7b2c27\u865f\uff09\u548c7\u67087\u65e5\u65bd\u884c\u7684\u300a\u85e5\u54c1\u4e0a\u5e02\u8a31\u53ef\u512a\u5148\u5be9\u8a55\u5be9\u6279\u5de5\u4f5c\u7a0b\u5e8f\uff08\u8a66\u884c\uff09\u300b\uff082020\u5e74\u7b2c82\u865f\uff09\uff0c\u901a\u904e\u8a2d\u7acb\u512a\u5148\u5be9\u8a55\u5be9\u5236\u5ea6\u4ee5\u52a0\u5feb\u5177\u6709\u91cd\u5927\u81e8\u5e8a\u50f9\u503c\u548c\u81e8\u5e8a\u6025\u9700\u65b0\u85e5\u7684\u958b\u767c\u3002\u5be9\u6279\u90e8\u9580\u5c07\u512a\u5148\u5be9\u6838\u548c\u8a55\u4f30\u7372\u5f97\u512a\u5148\u5be9\u8a55\u8cc7\u683c\u7684\u85e5\u54c1\uff0c\u6709\u5229\u65bc\u52a0\u5feb\u5e02\u5834\u51c6\u5165\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u820a\u91d1\u5c71\u548c\u4e2d\u570b\u8607\u5dde2025\u5e742\u6708&#8230;<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-298032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4\u00a0(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b          1.\u00a0\u00a0\u00a0\u00a0 http:\/\/abstracts.asco.org\/239\/AbstView_239_267235.html         2.\u00a0\u00a0\u00a0 Morton D, et al; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. DOI: 10.1200\/JCO.22.00046.         3.\u00a0\u00a0\u00a0 Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. DOI:10.1634\/theoncologist.13-S4-2         4.\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. DOI: 10.1080\/19420862.2019.1654303.         \u00a0           \u00a0\u00a0\u6839\u64daNMPA 2020\u5e747\u67081\u65e5\u65bd\u884c\u7684\u300a\u85e5\u54c1\u6ce8\u518a\u7ba1\u7406\u8fa6\u6cd5\u300b\uff08\u570b\u5bb6\u5e02\u5834\u76e3\u7763\u7ba1\u7406\u7e3d\u5c40\u4ee4\u7b2c27\u865f\uff09\u548c7\u67087\u65e5\u65bd\u884c\u7684\u300a\u85e5\u54c1\u4e0a\u5e02\u8a31\u53ef\u512a\u5148\u5be9\u8a55\u5be9\u6279\u5de5\u4f5c\u7a0b\u5e8f\uff08\u8a66\u884c\uff09\u300b\uff082020\u5e74\u7b2c82\u865f\uff09\uff0c\u901a\u904e\u8a2d\u7acb\u512a\u5148\u5be9\u8a55\u5be9\u5236\u5ea6\u4ee5\u52a0\u5feb\u5177\u6709\u91cd\u5927\u81e8\u5e8a\u50f9\u503c\u548c\u81e8\u5e8a\u6025\u9700\u65b0\u85e5\u7684\u958b\u767c\u3002\u5be9\u6279\u90e8\u9580\u5c07\u512a\u5148\u5be9\u6838\u548c\u8a55\u4f30\u7372\u5f97\u512a\u5148\u5be9\u8a55\u8cc7\u683c\u7684\u85e5\u54c1\uff0c\u6709\u5229\u65bc\u52a0\u5feb\u5e02\u5834\u51c6\u5165\u3002         \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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\u7b26\u5408\u7814\u7a76\u65b9\u6848\u5206\u6790(PP)\u96c6\u4e2d\uff0c\u4f0a\u5339\u6728\u55ae\u6297\u806f\u5408\u4fe1\u8fea\u5229\u55ae\u6297\u7d44pCR\u7387\u986f\u8457\u9ad8\u65bc\u4fe1\u8fea\u5229\u55ae\u6297\u55ae\u85e5\u7d44\uff0880.0% vs 47.7%\uff0cp=0.0007\uff09\u3002  \u5169\u500b\u7d44\u5225\u7684\u53d7\u8a66\u8005\u816b\u7624\u5b8c\u5168\u5207\u9664\uff08R0\uff09\u7387\u5747\u70ba100%\uff1b\u4e2d\u4f4d\u96a8\u8a2a\u6642\u95935.65\u500b\u6708\uff0c\u5169\u7d44\u5747\u672a\u767c\u751f\u75be\u75c5\u5fa9\u767c\u4e8b\u4ef6\u3002  \u4f0a\u5339\u6728\u55ae\u6297\u806f\u5408\u4fe1\u8fea\u5229\u55ae\u6297\u7d44\u8207\u4fe1\u8fea\u5229\u55ae\u6297\u55ae\u85e5\u7d44\u8853\u5f8c\u75c5\u7406\u6dcb\u5df4\u7d50\u967d\u6027\u7387\u5206\u5225\u70ba3.9%\u820715.9%\u3002\u6839\u64da\u6307\u5357\uff0c\u5927\u90e8\u5206\u53d7\u8a66\u8005\u53ef\u514d\u9664\u8853\u5f8c\u8f14\u52a9\u5316\u7642\u3002  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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4\u00a0(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b          1.\u00a0\u00a0\u00a0\u00a0 http:\/\/abstracts.asco.org\/239\/AbstView_239_267235.html         2.\u00a0\u00a0\u00a0 Morton D, et al; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. DOI: 10.1200\/JCO.22.00046.         3.\u00a0\u00a0\u00a0 Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. DOI:10.1634\/theoncologist.13-S4-2         4.\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. 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Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. DOI: 10.1200\\\/JCO.22.00046. 3.\u00a0\u00a0\u00a0 Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. DOI:10.1634\\\/theoncologist.13-S4-2 4.\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4\u00a0(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b          1.\u00a0\u00a0\u00a0\u00a0 http:\/\/abstracts.asco.org\/239\/AbstView_239_267235.html         2.\u00a0\u00a0\u00a0 Morton D, et al; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. DOI: 10.1200\/JCO.22.00046.         3.\u00a0\u00a0\u00a0 Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. DOI:10.1634\/theoncologist.13-S4-2         4.\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. 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\u672c\u516c\u53f8\u3001\u672c\u516c\u53f8\u8463\u4e8b\u53ca\u96c7\u54e1\u4ee3\u7406\u6982\u4e0d\u627f\u64d4\u00a0(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002 \u53c3\u8003\u6587\u737b          1.\u00a0\u00a0\u00a0\u00a0 http:\/\/abstracts.asco.org\/239\/AbstView_239_267235.html         2.\u00a0\u00a0\u00a0 Morton D, et al; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol. 2023 Mar 10;41(8):1541-1552. DOI: 10.1200\/JCO.22.00046.         3.\u00a0\u00a0\u00a0 Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist. 2008;13 Suppl 4:2-9. DOI:10.1634\/theoncologist.13-S4-2         4.\u00a0\u00a0\u00a0\u00a0 Wang J, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451. 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