{"id":291937,"date":"2025-01-21T19:00:00","date_gmt":"2025-01-21T11:00:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=291937"},"modified":"2025-01-21T19:00:00","modified_gmt":"2025-01-21T11:00:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e5%b0%8f%e5%88%86%e5%ad%90%e5%8f%a3%e6%9c%8dglp-1r%e6%bf%80%e5%8b%95%e5%8a%91asc30%e7%be%8e%e5%9c%8bia%e6%9c%9f%e5%96%ae%e5%8a%91%e9%87%8f%e9%81%9e%e5%a2%9e","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=291937","title":{"rendered":"\u6b4c\u79ae\u5ba3\u4f48\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291ASC30\u7f8e\u570bIa\u671f\u55ae\u5291\u91cf\u905e\u589e\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u6210\u679c\u4e26\u63d0\u4f9b\u9805\u76ee\u9032\u5c55\u60c5\u6cc1"},"content":{"rendered":"
\n

–\u00a0\u00a0\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08<\/i>SAD<\/i>\uff09\u7814\u7a76\u4e2d\uff0c<\/i>ASC30<\/i>\u53e3\u670d\u7247\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\u7684\uff08<\/i>dose-proportional<\/i>\uff09\u85e5\u4ee3\u52d5\u529b\u5b78\uff08<\/i>PK<\/i>\uff09\u7279\u5fb5\uff0c\u534a\u8870\u671f<\/i>(t1\/2<\/sub>)<\/i>\u9577\u9054<\/i>60<\/i>\u5c0f\u6642\uff0c\u652f\u6301\u6bcf\u65e5\u4e00\u6b21\u6216\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002<\/i><\/p>\n

–\u00a0\u00a0ASC30<\/i>\u53e3\u670d\u7247\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08<\/i>AE<\/i>\uff09\u5747\u70ba\u8f15\u5ea6\uff08<\/i>1<\/i>\u7d1a\uff09\u6216\u4e2d\u5ea6\uff08<\/i>2<\/i>\u7d1a\uff09\uff0c\u5927\u90e8\u5206<\/i>AE<\/i>\u8207\u80c3\u8178\u9053\uff08<\/i>GI<\/i>\uff09\u76f8\u95dc\u3002\u7121<\/i>3<\/i>\u7d1a\u6216\u4ee5\u4e0a<\/i>AE<\/i>\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08<\/i>SAE<\/i>\uff09\u3002\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08<\/i>ALT<\/i>\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08<\/i>AST<\/i>\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002<\/i><\/p>\n

–\u00a0\u00a0ASC30<\/i>\u53e3\u670d\u7247\u5728\u5ba4\u6eab\u4e0b\u7a69\u5b9a\u3002<\/i>ASC30<\/i>\u7247\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u9054<\/i>99%<\/i>\u3002<\/i><\/p>\n

–\u00a0\u00a0ASC30<\/i>\u65b0\u7247\u5291\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002<\/i><\/p>\n

–\u00a0\u00a0ASC30<\/i>\u53e3\u670d\u7247\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u7f8e\u570b<\/i>Ib<\/i>\u671f\u591a\u5291\u91cf\u905e\u589e\uff08<\/i>MAD<\/i>\uff09\u7814\u7a76\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548c<\/i>PK<\/i>\u7b49\u9802\u7dda\u7d50\u679c\u9810\u8a08\u65bc<\/i>2025<\/i>\u5e74<\/i>3<\/i>\u6708\u5e95\u516c\u4f48\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2025\u5e741\u670821\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48ASC30\u53e3\u670d\u7247\u6cbb\u7642<\/span>\u80a5\u80d6\u75c7\u60a3\u8005\uff08\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\uff1a30-40 kg\/m2<\/sup>\uff09\u7684\u7f8e\u570b\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06680440<\/a>\uff09\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u7d50\u679c\u3002\u8a72SAD\u7814\u7a76\u75315\u500b\u968a\u5217\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40\u6beb\u514b\uff09\u7d44\u6210\uff0c\u5171\u8a0840\u540d\u80a5\u80d6\u75c7\u60a3\u8005\uff0c\u65bc\u7a7a\u8179\u72c0\u614b\u4e0b\u9032\u884c\u3002<\/p>\n

\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684SAD\u7814\u7a76\u4e2d\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\u7684\uff08dose-proportional<\/span>\uff09\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5fb5\uff0c\u534a\u8870\u671f\uff08t1\/2<\/sub>\uff09\u9577\u905460\u5c0f\u6642\uff0c\u652f\u6301\u4e00\u65e5\u4e00\u6b21\u6216\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002\u8de8\u8a66\u9a57\u6bd4\u8f03\uff08cross-trial comparison\uff09\u8868\u660e\uff0c\u5728\u4eba\u9ad4\u4e2d\uff0c5 \u6beb\u514b ASC30 \u55ae\u5291\u91cf\u7684\u85e5\u7269\u66b4\u9732\u91cf\uff08\u66f2\u7dda\u4e0b\u9762\u7a4d\uff0c\u300cAUC\u300d\uff09\u662f 6 \u6beb\u514b orforglipron \u55ae\u5291\u91cf\u7684 2.2 \u500d[1]<\/sup>\u3002\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\u76f8\u6bd4\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u66f4\u512a\u8d8a\u7684PK\u7279\u5fb5\uff08\u5305\u62ec\u66f4\u9577\u7684t1\/2<\/sub>\u548c\u66f4\u9ad8\u7684AUC\uff09[1-3]<\/sup>\uff0c\u9019\u610f\u5473\u8457ASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u540c\u985e\u6700\u4f73\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002<\/p>\n

\u968a\u52175\u4e2d\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u5747\u53e3\u670d\u55ae\u5291\u91cf 40 \u6beb\u514b ASC30 \u53e3\u670d\u7247\u3002\u6578\u64da\u986f\u793a\uff0cASC30\u53e3\u670d\u7247\u7684PK\u7279\u5fb5\uff08\u5305\u62ecAUC\u548ct1\/2<\/sub>\uff09\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u57fa\u672c\u76f8\u540c\uff0c\u9019\u8868\u660eASC30\u53e3\u670d\u7247\u670d\u7528\u65b9\u4fbf\uff0c\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\uff0c\u4e0d\u53d7\u98df\u7269\u548c\u6c34\u7684\u5f71\u97ff\u3002<\/p>\n

ASC30\u53e3\u670d\u7247\u5728Ia\u671fSAD\u7814\u7a76\u4e2d\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002<\/span>ASC30\u53e3\u670d\u7247\u7684GI\u76f8\u95dc\u5b89\u5168\u6027\u7279\u5fb5\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u4e00\u81f4\u6216\u66f4\u4f73[1,3,4] <\/sup>\uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002<\/p>\n

\u88681. ASC30\u53e3\u670d\u7247\u6240\u6709GI\u76f8\u95dcAE\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09<\/p>\n

\n\n\n\n\n\n\n\n\n\n
\n

TEAE, n (%)<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291<\/span><\/p>\n

(N=10)<\/span><\/p>\n<\/td>\n

\n

\u968a\u5217 1
2\u6beb\u514bASC30
(N=6)<\/span><\/p>\n<\/td>\n

\n

\u968a\u5217 2
5\u6beb\u514bASC30
(N=6)<\/span><\/p>\n<\/td>\n

\n

\u968a\u5217 3
10\u6beb\u514bASC30
(N=6)<\/span><\/p>\n<\/td>\n

\n

\u968a\u5217 4
20\u6beb\u514bASC30
(N=6)<\/span><\/p>\n<\/td>\n

\n

\u968a\u5217 5
40 \u6beb\u514bASC30
(N=6)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

GI\u76f8\u95dc TEAE<\/span><\/p>\n<\/td>\n

\n

1 (10.0)<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

1 (16.7)<\/span><\/p>\n<\/td>\n

\n

4 (66.7)<\/span><\/p>\n<\/td>\n

\n

5 (83.3)<\/span><\/p>\n<\/td>\n

\n

6 (100.0)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8179\u7009<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

1 (16.7)<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4fbf\u79d8<\/span><\/p>\n<\/td>\n

\n

1 (10.0)<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

1 (16.7)<\/span><\/p>\n<\/td>\n

\n

1 (16.7)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5614\u5410<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

2 (33.3)<\/span><\/p>\n<\/td>\n

\n

5 (83.3)<\/span><\/p>\n<\/td>\n

\n

5 (83.3)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5641\u5fc3<\/span><\/p>\n<\/td>\n

\n

1 (10.0)<\/span><\/p>\n<\/td>\n

\n

0<\/span><\/p>\n<\/td>\n

\n

1 (16.7)<\/span><\/p>\n<\/td>\n

\n

3 (50.0)<\/span><\/p>\n<\/td>\n

\n

5 (83.3)<\/span><\/p>\n<\/td>\n

\n

6 (100.0)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

TEAE\uff1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1bGI\uff1a\u80c3\u8178\u9053\uff1b\u00a0n: \u6bcf\u500b\u5291\u91cf\u7d44\u767c\u751fGI\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4eba\u6578\uff1b
N\uff1a\u63a5\u53d7\u8a66\u9a57\u7528\u85e5\u54c1\u7684\u60a3\u8005\u4eba\u6578\u3002<\/p>\n

<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

ASC30\u53e3\u670d\u7247\u5291\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u6280\u8853\u7814\u767c\u800c\u6210\uff0c\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff0c\u7a69\u614b\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u905499%\u3002ASC30\u65b0\u7247\u5291\uff08\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff09\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002<\/p>\n

ASC30 \u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e0d\u52df\u96c6\u03b2-\u6291\u5236\u86cb\u767d\uff08without \u03b2-arrestin recruitment\uff09\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff08GLP-1R biased small molecule agonist\uff09\u3002ASC30 \u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u548c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u5747\u6210\u70ba\u53ef\u80fd\u3002\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0cASC30 \u5c0d GLP-1R \u7684\u9ad4\u5916\u85e5\u6548\u6bd4orforglipron\u9ad8\u51fa2\u52303\u500d\u3002\u5728\u5c0d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHPs\uff09\u9032\u884c\u7684\u975c\u8108\u8461\u8404\u7cd6\u8010\u53d7\u5be6\u9a57\uff08IVGTT\uff09\u4e2d\uff0c\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0c\u8207orforglipron\uff08\u5291\u91cf\uff1a6 \u6beb\u514b\/\u516c\u65a4\uff09\u76f8\u6bd4\uff0cASC30\uff08\u5291\u91cf\uff1a1.5 \u6beb\u514b\/\u516c\u65a4\uff09\u523a\u6fc0\u5206\u6ccc\u7684\u80f0\u5cf6\u7d20\u66f4\u591a\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u3002<\/p>\n

ASC30\u662f\u9996\u6b3e\u4e5f\u662f\u552f\u4e00\u4e00\u6b3e\u65e2\u53ef\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e5f\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002\u57fa\u65bc\u5176PK\u548c\u5b89\u5168\u6027\u7279\u5fb5\u4ee5\u53ca\u5c0dGLP-1R \u7684\u6fc0\u52d5\u4f5c\u7528\uff0cASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u7684 GLP-1R \u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002<\/p>\n

\u300cASC30\u53e3\u670d\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642<\/span>\u80a5\u80d6\u75c7\u60a3\u8005\u7684Ia\u671fSAD\u7814\u7a76\u7d50\u679c\u5c55\u73fe\u51fa\u4e86\u540c\u985e\u6700\u4f73\u7684\u6f5b\u529b\uff0c\u5c0d\u6b64\u6211\u5011\u975e\u5e38\u6fc0\u52d5\u3002\u6211\u5011\u5728SAD\u7814\u7a76\u4e2d\u5df2\u89c0\u5bdf\u5230\u4e86ASC30\u512a\u8d8a\u7684PK\u7279\u5fb5\uff0c\u671f\u5f85\u5728\u4eca\u5e74\u4e09\u6708\u5e95\u5206\u4eab\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684Ib\u671f28\u5929\u591a\u5291\u91cf\u905e\u589e\u8a66\u9a57\u7684\u85e5\u6548\u3001\u5b89\u5168\u6027\u548cPK\u6578\u64da\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC30\u4f5c\u70ba\u4e00\u7a2e\u5c0f\u5206\u5b50\u85e5\u7269\uff0c\u6709\u671b\u63d0\u4f9b\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u548c\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5169\u7a2e\u7d66\u85e5\u9078\u64c7\u3002\u300d<\/p>\n

ASC30<\/b>\u53e3\u670d\u7247\u7f8e\u570b<\/b>Ib<\/b>\u671f<\/b>MAD<\/b>\u7814\u7a76\u9032\u5c55<\/b><\/p>\n

ASC30\u53e3\u670d\u7247MAD\u7814\u7a76\u75313\u500b\u968a\u5217\u7d44\u6210\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff08weekly titrations\uff09\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u63a5\u53d7ASC30\u7247\u6216\u5b89\u6170\u5291\u7d66\u85e5\uff0c\u70ba\u671f28\u5929\u3002\u968a\u52171\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u548c20 \u6beb\u514b\uff09\u5df2\u5b8c\u6210\uff0c\u968a\u52172 \uff082\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40 \u6beb\u514b\uff09\u548c\u968a\u5217 3 \uff085\u6beb\u514b\u300115\u6beb\u514b\u300130\u6beb\u514b\u548c60\u6beb\u514b\uff09\u5c07\u5206\u5225\u65bc2025\u5e742\u6708\u4e0b\u65ec\u548c3\u6708\u4e0b\u65ec\u5b8c\u6210\u3002MAD\u7814\u7a76\u9802\u7dda\u7d50\u679c\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548cPK\u7b49\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e743\u6708\u5e95\u516c\u4f48\u3002<\/p>\n

ASC30<\/b>\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u7f8e\u570b<\/b>Ia<\/b>\u548c<\/b>Ib<\/b>\u671f\u81e8\u5e8a\u7814\u7a76<\/b><\/p>\n

ASC30\u53e3\u670d\u7247Ia\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u55ae\u5291\u91cf\u905e\u589e\uff085\u500b\u968a\u5217\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2<\/sup>\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548cPK\u3002<\/p>\n

ASC30\u53e3\u670d\u7247Ib\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u5291\u91cf\u905e\u589e\uff083\u500b\u968a\u5217\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u70ba\u671f28\u5929\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2<\/sup>\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u548c\u7642\u6548\u3002<\/p>\n

\u95dc\u65bc<\/b> ASC30<\/b><\/p>\n

ASC30\u662f\u4e00\u6b3e\u6b63\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u540c\u4e00\u5c0f\u5206\u5b50\u540c\u6642\u9069\u7528\u65bc\u76ae\u4e0b\u6ce8\u5c04\u548c\u53e3\u670d\u7247\u5291\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002ASC30\u662f\u4e00\u7a2e\u65b0\u578b\u5206\u5b50\u5be6\u9ad4\uff08NME\uff09\uff0c\u64c1\u6709\u7f8e\u570b\u548c\u5168\u7403\u5316\u5408\u7269\u5c08\u5229\u4fdd\u8b77\uff0c\u5c08\u5229\u4fdd\u8b77\u671f\u81f32044\u5e74\u3002<\/p>\n

\u53c3\u8003\u8cc7\u6599<\/b><\/p>\n

    \n
  1. Diabetes Obes Metab. 2023; 25:2634\u20132641.<\/li>\n
  2. Obesity 2024: Volume 32, Issue S1, Poster 342.<\/li>\n
  3. Obesity 2024: Volume 32, Issue S1, Poster 219.<\/li>\n
  4. Diabetes 2023: Volume 72, Issue Supplement_1, Poster 754.\n<\/li>\n<\/ol>\n

    \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/b><\/p>\n

    \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002<\/p>\n

    \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002<\/p>\n

    \u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

    Peter Vozzo<\/span>
    ICR Healthcare
    443-231-<\/span>0505 (\u7f8e\u56fd)
    Peter.vozzo@icrhealthcare.com<\/a><\/p>\n

    \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a
    +86-181-0650-9129 (\u4e2d\u570b)
    pr@ascletis.com<\/a>
    ir@ascletis.com<\/a>\u00a0<\/p>\n

    \u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    –\u00a0\u00a0\u5728\u80a5\u80d6\u75c7\u60a3\u8005…<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-291937","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u6b4c\u79ae\u5ba3\u4f48\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291ASC30\u7f8e\u570bIa\u671f\u55ae\u5291\u91cf\u905e\u589e\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u6210\u679c\u4e26\u63d0\u4f9b\u9805\u76ee\u9032\u5c55\u60c5\u6cc1 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" 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-\u00a0\u00a0ASC30\u65b0\u7247\u5291\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 -\u00a0\u00a0ASC30\u53e3\u670d\u7247\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u7f8e\u570bIb\u671f\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u7814\u7a76\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548cPK\u7b49\u9802\u7dda\u7d50\u679c\u9810\u8a08\u65bc2025\u5e743\u6708\u5e95\u516c\u4f48\u3002 \u9999\u6e2f2025\u5e741\u670821\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48ASC30\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\uff08\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\uff1a30-40 kg\/m2\uff09\u7684\u7f8e\u570b\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06680440\uff09\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u7d50\u679c\u3002\u8a72SAD\u7814\u7a76\u75315\u500b\u968a\u5217\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40\u6beb\u514b\uff09\u7d44\u6210\uff0c\u5171\u8a0840\u540d\u80a5\u80d6\u75c7\u60a3\u8005\uff0c\u65bc\u7a7a\u8179\u72c0\u614b\u4e0b\u9032\u884c\u3002 \u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684SAD\u7814\u7a76\u4e2d\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\u7684\uff08dose-proportional\uff09\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5fb5\uff0c\u534a\u8870\u671f\uff08t1\/2\uff09\u9577\u905460\u5c0f\u6642\uff0c\u652f\u6301\u4e00\u65e5\u4e00\u6b21\u6216\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002\u8de8\u8a66\u9a57\u6bd4\u8f03\uff08cross-trial comparison\uff09\u8868\u660e\uff0c\u5728\u4eba\u9ad4\u4e2d\uff0c5 \u6beb\u514b ASC30 \u55ae\u5291\u91cf\u7684\u85e5\u7269\u66b4\u9732\u91cf\uff08\u66f2\u7dda\u4e0b\u9762\u7a4d\uff0c\u300cAUC\u300d\uff09\u662f 6 \u6beb\u514b orforglipron \u55ae\u5291\u91cf\u7684 2.2 \u500d\u3002\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\u76f8\u6bd4\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u66f4\u512a\u8d8a\u7684PK\u7279\u5fb5\uff08\u5305\u62ec\u66f4\u9577\u7684t1\/2\u548c\u66f4\u9ad8\u7684AUC\uff09\uff0c\u9019\u610f\u5473\u8457ASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u540c\u985e\u6700\u4f73\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002 \u968a\u52175\u4e2d\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u5747\u53e3\u670d\u55ae\u5291\u91cf 40 \u6beb\u514b ASC30 \u53e3\u670d\u7247\u3002\u6578\u64da\u986f\u793a\uff0cASC30\u53e3\u670d\u7247\u7684PK\u7279\u5fb5\uff08\u5305\u62ecAUC\u548ct1\/2\uff09\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u57fa\u672c\u76f8\u540c\uff0c\u9019\u8868\u660eASC30\u53e3\u670d\u7247\u670d\u7528\u65b9\u4fbf\uff0c\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\uff0c\u4e0d\u53d7\u98df\u7269\u548c\u6c34\u7684\u5f71\u97ff\u3002 ASC30\u53e3\u670d\u7247\u5728Ia\u671fSAD\u7814\u7a76\u4e2d\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002ASC30\u53e3\u670d\u7247\u7684GI\u76f8\u95dc\u5b89\u5168\u6027\u7279\u5fb5\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u4e00\u81f4\u6216\u66f4\u4f73 \uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002 \u88681. ASC30\u53e3\u670d\u7247\u6240\u6709GI\u76f8\u95dcAE\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09 TEAE, n (%) \u5b89\u6170\u5291 (N=10) \u968a\u5217 12\u6beb\u514bASC30(N=6) \u968a\u5217 25\u6beb\u514bASC30(N=6) \u968a\u5217 310\u6beb\u514bASC30(N=6) \u968a\u5217 420\u6beb\u514bASC30(N=6) \u968a\u5217 540 \u6beb\u514bASC30(N=6) GI\u76f8\u95dc TEAE 1 (10.0) 0 1 (16.7) 4 (66.7) 5 (83.3) 6 (100.0) \u8179\u7009 0 0 1 (16.7) 0 0 0 \u4fbf\u79d8 1 (10.0) 0 0 0 1 (16.7) 1 (16.7) \u5614\u5410 0 0 0 2 (33.3) 5 (83.3) 5 (83.3) \u5641\u5fc3 1 (10.0) 0 1 (16.7) 3 (50.0) 5 (83.3) 6 (100.0) TEAE\uff1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1bGI\uff1a\u80c3\u8178\u9053\uff1b\u00a0n: \u6bcf\u500b\u5291\u91cf\u7d44\u767c\u751fGI\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4eba\u6578\uff1bN\uff1a\u63a5\u53d7\u8a66\u9a57\u7528\u85e5\u54c1\u7684\u60a3\u8005\u4eba\u6578\u3002 ASC30\u53e3\u670d\u7247\u5291\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u6280\u8853\u7814\u767c\u800c\u6210\uff0c\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff0c\u7a69\u614b\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u905499%\u3002ASC30\u65b0\u7247\u5291\uff08\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff09\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 ASC30 \u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e0d\u52df\u96c6\u03b2-\u6291\u5236\u86cb\u767d\uff08without \u03b2-arrestin recruitment\uff09\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff08GLP-1R biased small molecule agonist\uff09\u3002ASC30 \u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u548c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u5747\u6210\u70ba\u53ef\u80fd\u3002\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0cASC30 \u5c0d GLP-1R \u7684\u9ad4\u5916\u85e5\u6548\u6bd4orforglipron\u9ad8\u51fa2\u52303\u500d\u3002\u5728\u5c0d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHPs\uff09\u9032\u884c\u7684\u975c\u8108\u8461\u8404\u7cd6\u8010\u53d7\u5be6\u9a57\uff08IVGTT\uff09\u4e2d\uff0c\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0c\u8207orforglipron\uff08\u5291\u91cf\uff1a6 \u6beb\u514b\/\u516c\u65a4\uff09\u76f8\u6bd4\uff0cASC30\uff08\u5291\u91cf\uff1a1.5 \u6beb\u514b\/\u516c\u65a4\uff09\u523a\u6fc0\u5206\u6ccc\u7684\u80f0\u5cf6\u7d20\u66f4\u591a\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u3002 ASC30\u662f\u9996\u6b3e\u4e5f\u662f\u552f\u4e00\u4e00\u6b3e\u65e2\u53ef\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e5f\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002\u57fa\u65bc\u5176PK\u548c\u5b89\u5168\u6027\u7279\u5fb5\u4ee5\u53ca\u5c0dGLP-1R \u7684\u6fc0\u52d5\u4f5c\u7528\uff0cASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u7684 GLP-1R \u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002 \u300cASC30\u53e3\u670d\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\u7684Ia\u671fSAD\u7814\u7a76\u7d50\u679c\u5c55\u73fe\u51fa\u4e86\u540c\u985e\u6700\u4f73\u7684\u6f5b\u529b\uff0c\u5c0d\u6b64\u6211\u5011\u975e\u5e38\u6fc0\u52d5\u3002\u6211\u5011\u5728SAD\u7814\u7a76\u4e2d\u5df2\u89c0\u5bdf\u5230\u4e86ASC30\u512a\u8d8a\u7684PK\u7279\u5fb5\uff0c\u671f\u5f85\u5728\u4eca\u5e74\u4e09\u6708\u5e95\u5206\u4eab\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684Ib\u671f28\u5929\u591a\u5291\u91cf\u905e\u589e\u8a66\u9a57\u7684\u85e5\u6548\u3001\u5b89\u5168\u6027\u548cPK\u6578\u64da\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC30\u4f5c\u70ba\u4e00\u7a2e\u5c0f\u5206\u5b50\u85e5\u7269\uff0c\u6709\u671b\u63d0\u4f9b\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u548c\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5169\u7a2e\u7d66\u85e5\u9078\u64c7\u3002\u300d ASC30\u53e3\u670d\u7247\u7f8e\u570bIb\u671fMAD\u7814\u7a76\u9032\u5c55 ASC30\u53e3\u670d\u7247MAD\u7814\u7a76\u75313\u500b\u968a\u5217\u7d44\u6210\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff08weekly titrations\uff09\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u63a5\u53d7ASC30\u7247\u6216\u5b89\u6170\u5291\u7d66\u85e5\uff0c\u70ba\u671f28\u5929\u3002\u968a\u52171\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u548c20 \u6beb\u514b\uff09\u5df2\u5b8c\u6210\uff0c\u968a\u52172 \uff082\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40 \u6beb\u514b\uff09\u548c\u968a\u5217 3 \uff085\u6beb\u514b\u300115\u6beb\u514b\u300130\u6beb\u514b\u548c60\u6beb\u514b\uff09\u5c07\u5206\u5225\u65bc2025\u5e742\u6708\u4e0b\u65ec\u548c3\u6708\u4e0b\u65ec\u5b8c\u6210\u3002MAD\u7814\u7a76\u9802\u7dda\u7d50\u679c\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548cPK\u7b49\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e743\u6708\u5e95\u516c\u4f48\u3002 ASC30\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u7f8e\u570bIa\u548cIb\u671f\u81e8\u5e8a\u7814\u7a76 ASC30\u53e3\u670d\u7247Ia\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u55ae\u5291\u91cf\u905e\u589e\uff085\u500b\u968a\u5217\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548cPK\u3002 ASC30\u53e3\u670d\u7247Ib\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u5291\u91cf\u905e\u589e\uff083\u500b\u968a\u5217\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u70ba\u671f28\u5929\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u548c\u7642\u6548\u3002 \u95dc\u65bc ASC30 ASC30\u662f\u4e00\u6b3e\u6b63\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u540c\u4e00\u5c0f\u5206\u5b50\u540c\u6642\u9069\u7528\u65bc\u76ae\u4e0b\u6ce8\u5c04\u548c\u53e3\u670d\u7247\u5291\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002ASC30\u662f\u4e00\u7a2e\u65b0\u578b\u5206\u5b50\u5be6\u9ad4\uff08NME\uff09\uff0c\u64c1\u6709\u7f8e\u570b\u548c\u5168\u7403\u5316\u5408\u7269\u5c08\u5229\u4fdd\u8b77\uff0c\u5c08\u5229\u4fdd\u8b77\u671f\u81f32044\u5e74\u3002 \u53c3\u8003\u8cc7\u6599 Diabetes Obes Metab. 2023; 25:2634\u20132641. Obesity 2024: Volume 32, Issue S1, Poster 342. Obesity 2024: Volume 32, Issue S1, Poster 219. Diabetes 2023: Volume 72, Issue Supplement_1, Poster 754. \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u56fd)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=291937\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6b4c\u79ae\u5ba3\u4f48\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291ASC30\u7f8e\u570bIa\u671f\u55ae\u5291\u91cf\u905e\u589e\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u6210\u679c\u4e26\u63d0\u4f9b\u9805\u76ee\u9032\u5c55\u60c5\u6cc1 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"-\u00a0\u00a0\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u4e2d\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\u7684\uff08dose-proportional\uff09\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5fb5\uff0c\u534a\u8870\u671f(t1\/2)\u9577\u905460\u5c0f\u6642\uff0c\u652f\u6301\u6bcf\u65e5\u4e00\u6b21\u6216\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002 -\u00a0\u00a0ASC30\u53e3\u670d\u7247\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002 -\u00a0\u00a0ASC30\u53e3\u670d\u7247\u5728\u5ba4\u6eab\u4e0b\u7a69\u5b9a\u3002ASC30\u7247\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u905499%\u3002 -\u00a0\u00a0ASC30\u65b0\u7247\u5291\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 -\u00a0\u00a0ASC30\u53e3\u670d\u7247\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\u7684\u7f8e\u570bIb\u671f\u591a\u5291\u91cf\u905e\u589e\uff08MAD\uff09\u7814\u7a76\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548cPK\u7b49\u9802\u7dda\u7d50\u679c\u9810\u8a08\u65bc2025\u5e743\u6708\u5e95\u516c\u4f48\u3002 \u9999\u6e2f2025\u5e741\u670821\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u4f48ASC30\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\uff08\u9ad4\u91cd\u6307\u6578\uff08BMI\uff09\uff1a30-40 kg\/m2\uff09\u7684\u7f8e\u570b\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06680440\uff09\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u7d50\u679c\u3002\u8a72SAD\u7814\u7a76\u75315\u500b\u968a\u5217\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40\u6beb\u514b\uff09\u7d44\u6210\uff0c\u5171\u8a0840\u540d\u80a5\u80d6\u75c7\u60a3\u8005\uff0c\u65bc\u7a7a\u8179\u72c0\u614b\u4e0b\u9032\u884c\u3002 \u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684SAD\u7814\u7a76\u4e2d\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\u7684\uff08dose-proportional\uff09\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5fb5\uff0c\u534a\u8870\u671f\uff08t1\/2\uff09\u9577\u905460\u5c0f\u6642\uff0c\u652f\u6301\u4e00\u65e5\u4e00\u6b21\u6216\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002\u8de8\u8a66\u9a57\u6bd4\u8f03\uff08cross-trial comparison\uff09\u8868\u660e\uff0c\u5728\u4eba\u9ad4\u4e2d\uff0c5 \u6beb\u514b ASC30 \u55ae\u5291\u91cf\u7684\u85e5\u7269\u66b4\u9732\u91cf\uff08\u66f2\u7dda\u4e0b\u9762\u7a4d\uff0c\u300cAUC\u300d\uff09\u662f 6 \u6beb\u514b orforglipron \u55ae\u5291\u91cf\u7684 2.2 \u500d\u3002\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\u76f8\u6bd4\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u66f4\u512a\u8d8a\u7684PK\u7279\u5fb5\uff08\u5305\u62ec\u66f4\u9577\u7684t1\/2\u548c\u66f4\u9ad8\u7684AUC\uff09\uff0c\u9019\u610f\u5473\u8457ASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u540c\u985e\u6700\u4f73\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002 \u968a\u52175\u4e2d\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u5747\u53e3\u670d\u55ae\u5291\u91cf 40 \u6beb\u514b ASC30 \u53e3\u670d\u7247\u3002\u6578\u64da\u986f\u793a\uff0cASC30\u53e3\u670d\u7247\u7684PK\u7279\u5fb5\uff08\u5305\u62ecAUC\u548ct1\/2\uff09\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u57fa\u672c\u76f8\u540c\uff0c\u9019\u8868\u660eASC30\u53e3\u670d\u7247\u670d\u7528\u65b9\u4fbf\uff0c\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\uff0c\u4e0d\u53d7\u98df\u7269\u548c\u6c34\u7684\u5f71\u97ff\u3002 ASC30\u53e3\u670d\u7247\u5728Ia\u671fSAD\u7814\u7a76\u4e2d\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002ASC30\u53e3\u670d\u7247\u7684GI\u76f8\u95dc\u5b89\u5168\u6027\u7279\u5fb5\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u4e00\u81f4\u6216\u66f4\u4f73 \uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002 \u88681. ASC30\u53e3\u670d\u7247\u6240\u6709GI\u76f8\u95dcAE\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09 TEAE, n (%) \u5b89\u6170\u5291 (N=10) \u968a\u5217 12\u6beb\u514bASC30(N=6) \u968a\u5217 25\u6beb\u514bASC30(N=6) \u968a\u5217 310\u6beb\u514bASC30(N=6) \u968a\u5217 420\u6beb\u514bASC30(N=6) \u968a\u5217 540 \u6beb\u514bASC30(N=6) GI\u76f8\u95dc TEAE 1 (10.0) 0 1 (16.7) 4 (66.7) 5 (83.3) 6 (100.0) \u8179\u7009 0 0 1 (16.7) 0 0 0 \u4fbf\u79d8 1 (10.0) 0 0 0 1 (16.7) 1 (16.7) \u5614\u5410 0 0 0 2 (33.3) 5 (83.3) 5 (83.3) \u5641\u5fc3 1 (10.0) 0 1 (16.7) 3 (50.0) 5 (83.3) 6 (100.0) TEAE\uff1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1bGI\uff1a\u80c3\u8178\u9053\uff1b\u00a0n: \u6bcf\u500b\u5291\u91cf\u7d44\u767c\u751fGI\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4eba\u6578\uff1bN\uff1a\u63a5\u53d7\u8a66\u9a57\u7528\u85e5\u54c1\u7684\u60a3\u8005\u4eba\u6578\u3002 ASC30\u53e3\u670d\u7247\u5291\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u6280\u8853\u7814\u767c\u800c\u6210\uff0c\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff0c\u7a69\u614b\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u905499%\u3002ASC30\u65b0\u7247\u5291\uff08\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff09\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 ASC30 \u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e0d\u52df\u96c6\u03b2-\u6291\u5236\u86cb\u767d\uff08without \u03b2-arrestin recruitment\uff09\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff08GLP-1R biased small molecule agonist\uff09\u3002ASC30 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kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u548c\u7642\u6548\u3002 \u95dc\u65bc ASC30 ASC30\u662f\u4e00\u6b3e\u6b63\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u540c\u4e00\u5c0f\u5206\u5b50\u540c\u6642\u9069\u7528\u65bc\u76ae\u4e0b\u6ce8\u5c04\u548c\u53e3\u670d\u7247\u5291\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002ASC30\u662f\u4e00\u7a2e\u65b0\u578b\u5206\u5b50\u5be6\u9ad4\uff08NME\uff09\uff0c\u64c1\u6709\u7f8e\u570b\u548c\u5168\u7403\u5316\u5408\u7269\u5c08\u5229\u4fdd\u8b77\uff0c\u5c08\u5229\u4fdd\u8b77\u671f\u81f32044\u5e74\u3002 \u53c3\u8003\u8cc7\u6599 Diabetes Obes Metab. 2023; 25:2634\u20132641. Obesity 2024: Volume 32, Issue S1, Poster 342. Obesity 2024: Volume 32, Issue S1, Poster 219. Diabetes 2023: Volume 72, Issue Supplement_1, Poster 754. \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 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kg\\\/m2\uff09\u7684\u7f8e\u570b\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06680440\uff09\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u7d50\u679c\u3002\u8a72SAD\u7814\u7a76\u75315\u500b\u968a\u5217\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40\u6beb\u514b\uff09\u7d44\u6210\uff0c\u5171\u8a0840\u540d\u80a5\u80d6\u75c7\u60a3\u8005\uff0c\u65bc\u7a7a\u8179\u72c0\u614b\u4e0b\u9032\u884c\u3002 \u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684SAD\u7814\u7a76\u4e2d\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u8207\u5291\u91cf\u6210\u6bd4\u4f8b\u7684\uff08dose-proportional\uff09\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u7279\u5fb5\uff0c\u534a\u8870\u671f\uff08t1\\\/2\uff09\u9577\u905460\u5c0f\u6642\uff0c\u652f\u6301\u4e00\u65e5\u4e00\u6b21\u6216\u66f4\u4f4e\u983b\u7387\u7684\u53e3\u670d\u7d66\u85e5\u3002\u8de8\u8a66\u9a57\u6bd4\u8f03\uff08cross-trial comparison\uff09\u8868\u660e\uff0c\u5728\u4eba\u9ad4\u4e2d\uff0c5 \u6beb\u514b ASC30 \u55ae\u5291\u91cf\u7684\u85e5\u7269\u66b4\u9732\u91cf\uff08\u66f2\u7dda\u4e0b\u9762\u7a4d\uff0c\u300cAUC\u300d\uff09\u662f 6 \u6beb\u514b orforglipron \u55ae\u5291\u91cf\u7684 2.2 \u500d\u3002\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1\u53d7\u9ad4\uff08GLP-1R\uff09\u6fc0\u52d5\u5291\u76f8\u6bd4\uff0cASC30\u53e3\u670d\u7247\u986f\u793a\u51fa\u66f4\u512a\u8d8a\u7684PK\u7279\u5fb5\uff08\u5305\u62ec\u66f4\u9577\u7684t1\\\/2\u548c\u66f4\u9ad8\u7684AUC\uff09\uff0c\u9019\u610f\u5473\u8457ASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u540c\u985e\u6700\u4f73\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002 \u968a\u52175\u4e2d\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u5747\u53e3\u670d\u55ae\u5291\u91cf 40 \u6beb\u514b ASC30 \u53e3\u670d\u7247\u3002\u6578\u64da\u986f\u793a\uff0cASC30\u53e3\u670d\u7247\u7684PK\u7279\u5fb5\uff08\u5305\u62ecAUC\u548ct1\\\/2\uff09\u5728\u7a7a\u8179\u548c\u9032\u98df\u72c0\u614b\u4e0b\u57fa\u672c\u76f8\u540c\uff0c\u9019\u8868\u660eASC30\u53e3\u670d\u7247\u670d\u7528\u65b9\u4fbf\uff0c\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\uff0c\u4e0d\u53d7\u98df\u7269\u548c\u6c34\u7684\u5f71\u97ff\u3002 ASC30\u53e3\u670d\u7247\u5728Ia\u671fSAD\u7814\u7a76\u4e2d\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002ASC30\u53e3\u670d\u7247\u7684GI\u76f8\u95dc\u5b89\u5168\u6027\u7279\u5fb5\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u4e00\u81f4\u6216\u66f4\u4f73 \uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002 \u88681. ASC30\u53e3\u670d\u7247\u6240\u6709GI\u76f8\u95dcAE\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09 TEAE, n (%) \u5b89\u6170\u5291 (N=10) \u968a\u5217 12\u6beb\u514bASC30(N=6) \u968a\u5217 25\u6beb\u514bASC30(N=6) \u968a\u5217 310\u6beb\u514bASC30(N=6) \u968a\u5217 420\u6beb\u514bASC30(N=6) \u968a\u5217 540 \u6beb\u514bASC30(N=6) GI\u76f8\u95dc TEAE 1 (10.0) 0 1 (16.7) 4 (66.7) 5 (83.3) 6 (100.0) \u8179\u7009 0 0 1 (16.7) 0 0 0 \u4fbf\u79d8 1 (10.0) 0 0 0 1 (16.7) 1 (16.7) \u5614\u5410 0 0 0 2 (33.3) 5 (83.3) 5 (83.3) \u5641\u5fc3 1 (10.0) 0 1 (16.7) 3 (50.0) 5 (83.3) 6 (100.0) TEAE\uff1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1bGI\uff1a\u80c3\u8178\u9053\uff1b\u00a0n: \u6bcf\u500b\u5291\u91cf\u7d44\u767c\u751fGI\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4eba\u6578\uff1bN\uff1a\u63a5\u53d7\u8a66\u9a57\u7528\u85e5\u54c1\u7684\u60a3\u8005\u4eba\u6578\u3002 ASC30\u53e3\u670d\u7247\u5291\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u6280\u8853\u7814\u767c\u800c\u6210\uff0c\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff0c\u7a69\u614b\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u905499%\u3002ASC30\u65b0\u7247\u5291\uff08\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff09\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 ASC30 \u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e0d\u52df\u96c6\u03b2-\u6291\u5236\u86cb\u767d\uff08without \u03b2-arrestin recruitment\uff09\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff08GLP-1R biased small molecule agonist\uff09\u3002ASC30 \u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u548c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u5747\u6210\u70ba\u53ef\u80fd\u3002\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0cASC30 \u5c0d GLP-1R \u7684\u9ad4\u5916\u85e5\u6548\u6bd4orforglipron\u9ad8\u51fa2\u52303\u500d\u3002\u5728\u5c0d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHPs\uff09\u9032\u884c\u7684\u975c\u8108\u8461\u8404\u7cd6\u8010\u53d7\u5be6\u9a57\uff08IVGTT\uff09\u4e2d\uff0c\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0c\u8207orforglipron\uff08\u5291\u91cf\uff1a6 \u6beb\u514b\\\/\u516c\u65a4\uff09\u76f8\u6bd4\uff0cASC30\uff08\u5291\u91cf\uff1a1.5 \u6beb\u514b\\\/\u516c\u65a4\uff09\u523a\u6fc0\u5206\u6ccc\u7684\u80f0\u5cf6\u7d20\u66f4\u591a\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u3002 ASC30\u662f\u9996\u6b3e\u4e5f\u662f\u552f\u4e00\u4e00\u6b3e\u65e2\u53ef\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e5f\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002\u57fa\u65bc\u5176PK\u548c\u5b89\u5168\u6027\u7279\u5fb5\u4ee5\u53ca\u5c0dGLP-1R \u7684\u6fc0\u52d5\u4f5c\u7528\uff0cASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u7684 GLP-1R \u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002 \u300cASC30\u53e3\u670d\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\u7684Ia\u671fSAD\u7814\u7a76\u7d50\u679c\u5c55\u73fe\u51fa\u4e86\u540c\u985e\u6700\u4f73\u7684\u6f5b\u529b\uff0c\u5c0d\u6b64\u6211\u5011\u975e\u5e38\u6fc0\u52d5\u3002\u6211\u5011\u5728SAD\u7814\u7a76\u4e2d\u5df2\u89c0\u5bdf\u5230\u4e86ASC30\u512a\u8d8a\u7684PK\u7279\u5fb5\uff0c\u671f\u5f85\u5728\u4eca\u5e74\u4e09\u6708\u5e95\u5206\u4eab\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684Ib\u671f28\u5929\u591a\u5291\u91cf\u905e\u589e\u8a66\u9a57\u7684\u85e5\u6548\u3001\u5b89\u5168\u6027\u548cPK\u6578\u64da\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC30\u4f5c\u70ba\u4e00\u7a2e\u5c0f\u5206\u5b50\u85e5\u7269\uff0c\u6709\u671b\u63d0\u4f9b\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u548c\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5169\u7a2e\u7d66\u85e5\u9078\u64c7\u3002\u300d 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Obesity 2024: Volume 32, Issue S1, Poster 342. Obesity 2024: Volume 32, Issue S1, Poster 219. 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ASC30\u53e3\u670d\u7247\u5728Ia\u671fSAD\u7814\u7a76\u4e2d\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002ASC30\u53e3\u670d\u7247\u7684GI\u76f8\u95dc\u5b89\u5168\u6027\u7279\u5fb5\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u4e00\u81f4\u6216\u66f4\u4f73 \uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002 \u88681. ASC30\u53e3\u670d\u7247\u6240\u6709GI\u76f8\u95dcAE\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09 TEAE, n (%) \u5b89\u6170\u5291 (N=10) \u968a\u5217 12\u6beb\u514bASC30(N=6) \u968a\u5217 25\u6beb\u514bASC30(N=6) \u968a\u5217 310\u6beb\u514bASC30(N=6) \u968a\u5217 420\u6beb\u514bASC30(N=6) \u968a\u5217 540 \u6beb\u514bASC30(N=6) GI\u76f8\u95dc TEAE 1 (10.0) 0 1 (16.7) 4 (66.7) 5 (83.3) 6 (100.0) \u8179\u7009 0 0 1 (16.7) 0 0 0 \u4fbf\u79d8 1 (10.0) 0 0 0 1 (16.7) 1 (16.7) \u5614\u5410 0 0 0 2 (33.3) 5 (83.3) 5 (83.3) \u5641\u5fc3 1 (10.0) 0 1 (16.7) 3 (50.0) 5 (83.3) 6 (100.0) TEAE\uff1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1bGI\uff1a\u80c3\u8178\u9053\uff1b\u00a0n: \u6bcf\u500b\u5291\u91cf\u7d44\u767c\u751fGI\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4eba\u6578\uff1bN\uff1a\u63a5\u53d7\u8a66\u9a57\u7528\u85e5\u54c1\u7684\u60a3\u8005\u4eba\u6578\u3002 ASC30\u53e3\u670d\u7247\u5291\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u6280\u8853\u7814\u767c\u800c\u6210\uff0c\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff0c\u7a69\u614b\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u905499%\u3002ASC30\u65b0\u7247\u5291\uff08\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff09\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 ASC30 \u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e0d\u52df\u96c6\u03b2-\u6291\u5236\u86cb\u767d\uff08without \u03b2-arrestin recruitment\uff09\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff08GLP-1R biased small molecule agonist\uff09\u3002ASC30 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ASC30\u662f\u9996\u6b3e\u4e5f\u662f\u552f\u4e00\u4e00\u6b3e\u65e2\u53ef\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e5f\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002\u57fa\u65bc\u5176PK\u548c\u5b89\u5168\u6027\u7279\u5fb5\u4ee5\u53ca\u5c0dGLP-1R \u7684\u6fc0\u52d5\u4f5c\u7528\uff0cASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u7684 GLP-1R \u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002 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ASC30\u53e3\u670d\u7247\u7f8e\u570bIb\u671fMAD\u7814\u7a76\u9032\u5c55 ASC30\u53e3\u670d\u7247MAD\u7814\u7a76\u75313\u500b\u968a\u5217\u7d44\u6210\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff08weekly titrations\uff09\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u63a5\u53d7ASC30\u7247\u6216\u5b89\u6170\u5291\u7d66\u85e5\uff0c\u70ba\u671f28\u5929\u3002\u968a\u52171\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u548c20 \u6beb\u514b\uff09\u5df2\u5b8c\u6210\uff0c\u968a\u52172 \uff082\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40 \u6beb\u514b\uff09\u548c\u968a\u5217 3 \uff085\u6beb\u514b\u300115\u6beb\u514b\u300130\u6beb\u514b\u548c60\u6beb\u514b\uff09\u5c07\u5206\u5225\u65bc2025\u5e742\u6708\u4e0b\u65ec\u548c3\u6708\u4e0b\u65ec\u5b8c\u6210\u3002MAD\u7814\u7a76\u9802\u7dda\u7d50\u679c\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548cPK\u7b49\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e743\u6708\u5e95\u516c\u4f48\u3002 ASC30\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u7f8e\u570bIa\u548cIb\u671f\u81e8\u5e8a\u7814\u7a76 ASC30\u53e3\u670d\u7247Ia\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u55ae\u5291\u91cf\u905e\u589e\uff085\u500b\u968a\u5217\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548cPK\u3002 ASC30\u53e3\u670d\u7247Ib\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u5291\u91cf\u905e\u589e\uff083\u500b\u968a\u5217\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u70ba\u671f28\u5929\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u548c\u7642\u6548\u3002 \u95dc\u65bc ASC30 ASC30\u662f\u4e00\u6b3e\u6b63\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u540c\u4e00\u5c0f\u5206\u5b50\u540c\u6642\u9069\u7528\u65bc\u76ae\u4e0b\u6ce8\u5c04\u548c\u53e3\u670d\u7247\u5291\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002ASC30\u662f\u4e00\u7a2e\u65b0\u578b\u5206\u5b50\u5be6\u9ad4\uff08NME\uff09\uff0c\u64c1\u6709\u7f8e\u570b\u548c\u5168\u7403\u5316\u5408\u7269\u5c08\u5229\u4fdd\u8b77\uff0c\u5c08\u5229\u4fdd\u8b77\u671f\u81f32044\u5e74\u3002 \u53c3\u8003\u8cc7\u6599 Diabetes Obes Metab. 2023; 25:2634\u20132641. Obesity 2024: Volume 32, Issue S1, Poster 342. Obesity 2024: Volume 32, Issue S1, Poster 219. Diabetes 2023: Volume 72, Issue Supplement_1, Poster 754. \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u56fd)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0 \u00a0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=291937","og_locale":"zh_TW","og_type":"article","og_title":"\u6b4c\u79ae\u5ba3\u4f48\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291ASC30\u7f8e\u570bIa\u671f\u55ae\u5291\u91cf\u905e\u589e\u7814\u7a76\u53d6\u5f97\u7a4d\u6975\u6210\u679c\u4e26\u63d0\u4f9b\u9805\u76ee\u9032\u5c55\u60c5\u6cc1 - 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Obesity 2024: Volume 32, Issue S1, Poster 342. Obesity 2024: Volume 32, Issue S1, Poster 219. 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ASC30\u53e3\u670d\u7247\u5728Ia\u671fSAD\u7814\u7a76\u4e2d\u6574\u9ad4\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u6240\u6709\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09\uff0c\u5927\u90e8\u5206AE\u8207\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u3002\u71213\u7d1a\u6216\u4ee5\u4e0aAE\uff0c\u4e5f\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002ASC30\u53e3\u670d\u7247\u7684GI\u76f8\u95dc\u5b89\u5168\u6027\u7279\u5fb5\u8207\u5176\u5b83\u5728\u7814\u5c0f\u5206\u5b50\u53e3\u670dGLP-1R\u6fc0\u52d5\u5291\u4e00\u81f4\u6216\u66f4\u4f73 \uff08\u88681\uff09\u3002\u6b64\u5916\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u3001\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u548c\u5176\u5b83\u809d\u9176\u5747\u5728\u6b63\u5e38\u7bc4\u570d\u5167\u3002 \u88681. ASC30\u53e3\u670d\u7247\u6240\u6709GI\u76f8\u95dcAE\u5747\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u6216\u4e2d\u5ea6\uff082\u7d1a\uff09 TEAE, n (%) \u5b89\u6170\u5291 (N=10) \u968a\u5217 12\u6beb\u514bASC30(N=6) \u968a\u5217 25\u6beb\u514bASC30(N=6) \u968a\u5217 310\u6beb\u514bASC30(N=6) \u968a\u5217 420\u6beb\u514bASC30(N=6) \u968a\u5217 540 \u6beb\u514bASC30(N=6) GI\u76f8\u95dc TEAE 1 (10.0) 0 1 (16.7) 4 (66.7) 5 (83.3) 6 (100.0) \u8179\u7009 0 0 1 (16.7) 0 0 0 \u4fbf\u79d8 1 (10.0) 0 0 0 1 (16.7) 1 (16.7) \u5614\u5410 0 0 0 2 (33.3) 5 (83.3) 5 (83.3) \u5641\u5fc3 1 (10.0) 0 1 (16.7) 3 (50.0) 5 (83.3) 6 (100.0) TEAE\uff1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff1bGI\uff1a\u80c3\u8178\u9053\uff1b\u00a0n: \u6bcf\u500b\u5291\u91cf\u7d44\u767c\u751fGI\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u7684\u60a3\u8005\u4eba\u6578\uff1bN\uff1a\u63a5\u53d7\u8a66\u9a57\u7528\u85e5\u54c1\u7684\u60a3\u8005\u4eba\u6578\u3002 ASC30\u53e3\u670d\u7247\u5291\u5229\u7528\u6b4c\u79ae\u5c08\u6709\u6280\u8853\u7814\u767c\u800c\u6210\uff0c\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff0c\u7a69\u614b\u76f8\u5c0d\u53e3\u670d\u751f\u7269\u5229\u7528\u5ea6\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u905499%\u3002ASC30\u65b0\u7247\u5291\uff08\u5ba4\u6eab\u4e0b\u7a69\u5b9a\uff09\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u7684\u6578\u64da\u652f\u6301\u66f4\u4f4e\u983b\u7387\u53e3\u670d\u7d66\u85e5\uff0c\u6216\u53ef\u9054\u4e00\u9031\u4e00\u6b21\u3002 ASC30 \u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u4e0d\u52df\u96c6\u03b2-\u6291\u5236\u86cb\u767d\uff08without \u03b2-arrestin recruitment\uff09\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff08GLP-1R biased small molecule agonist\uff09\u3002ASC30 \u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u548c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7d66\u85e5\u5747\u6210\u70ba\u53ef\u80fd\u3002\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0cASC30 \u5c0d GLP-1R \u7684\u9ad4\u5916\u85e5\u6548\u6bd4orforglipron\u9ad8\u51fa2\u52303\u500d\u3002\u5728\u5c0d\u975e\u4eba\u9748\u9577\u985e\u52d5\u7269\uff08NHPs\uff09\u9032\u884c\u7684\u975c\u8108\u8461\u8404\u7cd6\u8010\u53d7\u5be6\u9a57\uff08IVGTT\uff09\u4e2d\uff0c\u7d93\u904e\u982d\u5c0d\u982d\u6bd4\u8f03\uff0c\u8207orforglipron\uff08\u5291\u91cf\uff1a6 \u6beb\u514b\/\u516c\u65a4\uff09\u76f8\u6bd4\uff0cASC30\uff08\u5291\u91cf\uff1a1.5 \u6beb\u514b\/\u516c\u65a4\uff09\u523a\u6fc0\u5206\u6ccc\u7684\u80f0\u5cf6\u7d20\u66f4\u591a\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u3002 ASC30\u662f\u9996\u6b3e\u4e5f\u662f\u552f\u4e00\u4e00\u6b3e\u65e2\u53ef\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u4e5f\u53ef\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u5c0f\u5206\u5b50GLP-1R\u6fc0\u52d5\u5291\u3002\u57fa\u65bc\u5176PK\u548c\u5b89\u5168\u6027\u7279\u5fb5\u4ee5\u53ca\u5c0dGLP-1R \u7684\u6fc0\u52d5\u4f5c\u7528\uff0cASC30\u53e3\u670d\u7247\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u7684 GLP-1R \u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002 \u300cASC30\u53e3\u670d\u6bcf\u65e5\u4e00\u6b21\u6cbb\u7642\u80a5\u80d6\u75c7\u60a3\u8005\u7684Ia\u671fSAD\u7814\u7a76\u7d50\u679c\u5c55\u73fe\u51fa\u4e86\u540c\u985e\u6700\u4f73\u7684\u6f5b\u529b\uff0c\u5c0d\u6b64\u6211\u5011\u975e\u5e38\u6fc0\u52d5\u3002\u6211\u5011\u5728SAD\u7814\u7a76\u4e2d\u5df2\u89c0\u5bdf\u5230\u4e86ASC30\u512a\u8d8a\u7684PK\u7279\u5fb5\uff0c\u671f\u5f85\u5728\u4eca\u5e74\u4e09\u6708\u5e95\u5206\u4eab\u5728\u80a5\u80d6\u75c7\u60a3\u8005\u4e2d\u9032\u884c\u7684Ib\u671f28\u5929\u591a\u5291\u91cf\u905e\u589e\u8a66\u9a57\u7684\u85e5\u6548\u3001\u5b89\u5168\u6027\u548cPK\u6578\u64da\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\uff0c\u300cASC30\u4f5c\u70ba\u4e00\u7a2e\u5c0f\u5206\u5b50\u85e5\u7269\uff0c\u6709\u671b\u63d0\u4f9b\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u548c\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5169\u7a2e\u7d66\u85e5\u9078\u64c7\u3002\u300d ASC30\u53e3\u670d\u7247\u7f8e\u570bIb\u671fMAD\u7814\u7a76\u9032\u5c55 ASC30\u53e3\u670d\u7247MAD\u7814\u7a76\u75313\u500b\u968a\u5217\u7d44\u6210\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff08weekly titrations\uff09\uff0c\u80a5\u80d6\u75c7\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u63a5\u53d7ASC30\u7247\u6216\u5b89\u6170\u5291\u7d66\u85e5\uff0c\u70ba\u671f28\u5929\u3002\u968a\u52171\uff082\u6beb\u514b\u30015\u6beb\u514b\u300110\u6beb\u514b\u548c20 \u6beb\u514b\uff09\u5df2\u5b8c\u6210\uff0c\u968a\u52172 \uff082\u6beb\u514b\u300110\u6beb\u514b\u300120\u6beb\u514b\u548c40 \u6beb\u514b\uff09\u548c\u968a\u5217 3 \uff085\u6beb\u514b\u300115\u6beb\u514b\u300130\u6beb\u514b\u548c60\u6beb\u514b\uff09\u5c07\u5206\u5225\u65bc2025\u5e742\u6708\u4e0b\u65ec\u548c3\u6708\u4e0b\u65ec\u5b8c\u6210\u3002MAD\u7814\u7a76\u9802\u7dda\u7d50\u679c\u7684\u6e1b\u91cd\u3001\u5b89\u5168\u6027\u548cPK\u7b49\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e743\u6708\u5e95\u516c\u4f48\u3002 ASC30\u53e3\u670d\u7247\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u7f8e\u570bIa\u548cIb\u671f\u81e8\u5e8a\u7814\u7a76 ASC30\u53e3\u670d\u7247Ia\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u55ae\u5291\u91cf\u905e\u589e\uff085\u500b\u968a\u5217\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548cPK\u3002 ASC30\u53e3\u670d\u7247Ib\u671f\u7814\u7a76\uff08\u6bcf\u65e5\u4e00\u6b21\uff09\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u5291\u91cf\u905e\u589e\uff083\u500b\u968a\u5217\uff0c\u6bcf\u9031\u5291\u91cf\u905e\u589e\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u70ba\u671f28\u5929\uff09\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30ASC30\u7247\u5728\u80a5\u80d6\u75c7\u60a3\u8005\uff08BMI\uff1a30-40 kg\/m2\uff09\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u548c\u7642\u6548\u3002 \u95dc\u65bc ASC30 ASC30\u662f\u4e00\u6b3e\u6b63\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7684\u5c0f\u5206\u5b50GLP-1R\u504f\u5411\u6fc0\u52d5\u5291\uff0c\u5177\u6709\u7368\u7279\u548c\u5dee\u7570\u5316\u6027\u8cea\uff0c\u4f7f\u5f97\u540c\u4e00\u5c0f\u5206\u5b50\u540c\u6642\u9069\u7528\u65bc\u76ae\u4e0b\u6ce8\u5c04\u548c\u53e3\u670d\u7247\u5291\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\u3002ASC30\u662f\u4e00\u7a2e\u65b0\u578b\u5206\u5b50\u5be6\u9ad4\uff08NME\uff09\uff0c\u64c1\u6709\u7f8e\u570b\u548c\u5168\u7403\u5316\u5408\u7269\u5c08\u5229\u4fdd\u8b77\uff0c\u5c08\u5229\u4fdd\u8b77\u671f\u81f32044\u5e74\u3002 \u53c3\u8003\u8cc7\u6599 Diabetes Obes Metab. 2023; 25:2634\u20132641. Obesity 2024: Volume 32, Issue S1, Poster 342. Obesity 2024: Volume 32, Issue S1, Poster 219. Diabetes 2023: Volume 72, Issue Supplement_1, Poster 754. \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter VozzoICR Healthcare443-231-0505 (\u7f8e\u56fd)Peter.vozzo@icrhealthcare.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a+86-181-0650-9129 (\u4e2d\u570b)pr@ascletis.comir@ascletis.com\u00a0 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