{"id":284832,"date":"2024-12-18T22:02:00","date_gmt":"2024-12-18T14:02:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=284832"},"modified":"2024-12-18T22:02:00","modified_gmt":"2024-12-18T14:02:00","slug":"%e6%ad%8c%e7%a6%ae%e5%ae%a3%e4%bd%88%e6%b2%bb%e7%99%82%e8%82%a5%e8%83%96%e7%97%87%e7%9a%84%e6%b8%9b%e9%87%8d%e4%b8%8d%e6%b8%9b%e8%82%8c%e5%80%99%e9%81%b8%e8%97%a5%e7%89%a9asc47%e8%88%87%e5%8f%b8","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=284832","title":{"rendered":"\u6b4c\u79ae\u5ba3\u4f48\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7684\u6e1b\u91cd\u6548\u679c"},"content":{"rendered":"
\n

– \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08<\/i>DIO<\/i>\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0c<\/i>ASC47<\/i>\u4f4e\u5291\u91cf\u806f\u5408\u7528\u85e5 <\/span><\/i>1<\/span><\/i>\uff08<\/i>ASC47<\/i>\uff0c<\/i>3 mg\/kg<\/i>\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c<\/i>30 nmol\/kg, <\/i>\u76ae\u4e0b\u6ce8\u5c04<\/i>, <\/i>\u6bcf\u65e5\u4e00\u6b21\uff09<\/i>\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08<\/i>30 nmol\/kg, <\/i>\u76ae\u4e0b\u6ce8\u5c04<\/i>, <\/i>\u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d<\/i>36.2%<\/i>\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d<\/i>23.1%<\/i>\uff0c<\/i>\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd<\/i>56.7%<\/i><\/span>\u3002
<\/i>– \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167<\/i> ASC47 <\/i>\u4f4e\u5291\u91cf <\/i>1<\/i><\/span>\uff08<\/i>ASC47<\/i>\uff0c<\/i>3 <\/i>mg\/kg<\/i>\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba<\/span><\/i> <\/span>20 mg<\/i>\u3002<\/i>\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08<\/i>LDL-C<\/i>\uff09\u504f\u9ad8\u53d7\u8a66\u8005<\/i> I <\/i>\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08<\/i>SAD<\/i>\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f3<\/i>90 mg<\/i>\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c<\/i>ASC47 <\/i>\u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002
<\/i>– \u4f4e\u5291\u91cf<\/i>ASC47<\/i>\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cf<\/i>ASC47<\/i>\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff08<\/i>68.8%<\/i>\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff08<\/i>66.0%<\/i>\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd<\/span>\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\u3002
<\/i>– \u4f4e\u5291\u91cf<\/i>ASC47<\/i>\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08<\/i>ALT<\/i>\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e<\/i>\u3002<\/i><\/p>\n

\u9999\u6e2f<\/span>2024\u5e7412\u670818\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\uff0c\u540c\u985e\u9996\u5275<\/span>\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002<\/p>\n

ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002<\/p>\n

\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590<\/a>\uff09\u7684\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u70ba21\u5929\u3002\u6b64\u5916\uff0cASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7576\u524d\u5291\u91cf\u5df2\u905e\u589e\u81f390 mg\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\uff0c\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\uff08\u93c8\u63a5<\/a>\uff09\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002<\/p>\n

\u5728\u6b64\u524d\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5e38\u898f\u5291\u91cfASC47\uff0845 mg\/kg, \u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u55ae\u85e5\u986f\u793a\u51fa\u7e3d\u9ad4\u91cd\u4e0b\u964d24.6%\u7684\u7642\u6548\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08\u4e0b\u964d23.1%\uff0c30 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5<\/span>\u4e00\u6b21\uff09\u7642\u6548\u76f8\u4f3c\u3002\u5e38\u898f\u5291\u91cfASC47\u4f7f\u808c\u8089\u7e3d\u91cf\u589e\u52a05.8%\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u4f7f\u808c\u8089\u7e3d\u91cf\u6e1b\u5c119.3%\uff08\u93c8\u63a5<\/a>\uff09\u3002<\/p>\n

\u4f4e\u5291\u91cf<\/u>ASC47<\/u>\u806f\u5408\u7642\u6cd5\u7684\u8a73\u7d30\u81e8\u5e8a\u524d\u6578\u64da<\/u><\/p>\n

\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\/kg\u62169 mg\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5<\/span>\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5<\/span>\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1<\/span>\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%<\/span>\uff08\u8868 1\uff09\u3002<\/p>\n

\u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n
\n

\u7d44\u5225<\/span><\/p>\n<\/td>\n

\n

\u7d66\u85e5<\/span><\/p>\n<\/td>\n

\n

\u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316<\/span><\/p>\n<\/td>\n

\n

\u808c\u8089\u7e3d\u91cf\/\u7e3d\u9ad4\u91cd<\/span><\/p>\n<\/td>\n

\n

\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291<\/span><\/p>\n<\/td>\n

\n

+8.53\u00a0%<\/span><\/p>\n<\/td>\n

\n

66.0\u00a0%<\/span><\/p>\n<\/td>\n

\n

308<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291<\/span><\/p>\n<\/td>\n

\n

+8.53\u00a0%<\/span><\/p>\n<\/td>\n

\n

46.6\u00a0%<\/span><\/p>\n<\/td>\n

\n

378<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC47\u4f4e\u5291\u91cf 1<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

3 mg\/kg, SQ, Q4W<\/span><\/p>\n<\/td>\n

\n

+5.54\u00a0%<\/span><\/p>\n<\/td>\n

\n

48.6\u00a0%<\/span><\/p>\n<\/td>\n

\n

388<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC47\u4f4e\u5291\u91cf 2<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

9 mg\/kg, SQ, Q4W<\/span><\/p>\n<\/td>\n

\n

-1.55\u00a0%<\/span><\/p>\n<\/td>\n

\n

52.1\u00a0%<\/span><\/p>\n<\/td>\n

\n

348<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg<\/span><\/p>\n

SQ, QD<\/span><\/p>\n<\/td>\n

\n

-23.1\u00a0%<\/span><\/p>\n<\/td>\n

\n

57.2\u00a0%<\/span><\/p>\n<\/td>\n

\n

211<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5291\u91cfASC47
\u806f\u5408\u7528\u85e51\u6cbb\u7642
\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

3 mg\/kg, SQ, Q4W<\/span><\/p>\n

+\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

-36.2%<\/span><\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp<\/i><0.0001)<\/span><\/p>\n<\/td>\n

\n

68.8%<\/span><\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp<\/i>=0.0001)<\/span><\/p>\n<\/td>\n

\n

251<\/span><\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.0385)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5291\u91cfASC47
\u806f\u5408\u7528\u85e52\u6cbb\u7642
\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

9 mg\/kg, SQ, Q4W<\/span><\/p>\n

+\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

-35.9%<\/span><\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp<\/span><\/i><0.0001)<\/span><\/p>\n<\/td>\n

\n

68.8%<\/span><\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.0001)<\/span><\/p>\n<\/td>\n

\n

267<\/span><\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.001)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u8a3b\uff1a<\/i>\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21<\/p>\n

\u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1<\/span>\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04<\/span>\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002<\/p>\n

\u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd<\/span>\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206<\/span>\u81f3\u5065\u5eb7\u6c34<\/span>\u5e73\uff08\u88681\uff09\u3002<\/p>\n

\u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002<\/p>\n

\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002<\/p>\n

\u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e<\/p>\n

\n\n\n\n\n\n\n\n\n\n\n
\n

\u7d44\u5225<\/span><\/p>\n<\/td>\n

\n

\u7d66\u85e5<\/span><\/p>\n<\/td>\n

\n

ALT\u00a0(U\/L)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291<\/span><\/p>\n<\/td>\n

\n

31.5<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291<\/span><\/p>\n<\/td>\n

\n

234<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC47\u4f4e\u5291\u91cf 1<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

3 mg\/kg, SQ, Q4W<\/span><\/p>\n<\/td>\n

\n

182<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC47\u4f4e\u5291\u91cf 2<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

9 mg\/kg, SQ, Q4W<\/span><\/p>\n<\/td>\n

\n

159<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

32.9<\/span><\/p>\n

\uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7
\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316<\/span><\/i>\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5291\u91cfASC47\u806f\u5408\u7528
\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

3 mg\/kg, SQ, Q4W<\/span><\/p>\n

+\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

54.1<\/span><\/p>\n

\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<\/span><\/i><0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7
\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f
\u8457\u8b8a\u5316 )<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5291\u91cfASC47\u806f\u5408\u7528
\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

9 mg\/kg, SQ, Q4W<\/span><\/p>\n

+\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

70.0<\/span><\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c<\/span>p<\/span><0.0001<\/span>\uff1b\u5c0d\u6bd4\u5065\u5eb7
\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f
\u8457\u8b8a\u5316<\/span><\/i>)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u8a3b\uff1a<\/i>\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21<\/p>\n

\u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002<\/p>\n

\u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e<\/p>\n

\n\n\n\n\n\n\n\n\n
\n

\u7d44\u5225<\/span><\/p>\n<\/td>\n

\n

\u7d66\u85e5<\/span><\/p>\n<\/td>\n

\n

\u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\/L)<\/span><\/p>\n<\/td>\n

\n

\u81bd\u56fa\u9187\u00a0(mmoL\/L)<\/span><\/p>\n<\/td>\n

\n

LDL-C (mmoL\/L)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u5b89\u6170\u5291<\/span><\/p>\n<\/td>\n

\n

7.5<\/span><\/p>\n<\/td>\n

\n

3.53<\/span><\/p>\n<\/td>\n

\n

0.50<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u00a0\u5b89\u6170\u5291\u00a0<\/span><\/p>\n<\/td>\n

\n

9.2<\/span><\/p>\n<\/td>\n

\n

6.98<\/span><\/p>\n<\/td>\n

\n

1.41<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC47\u4f4e\u5291\u91cf 1<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

3 mg\/kg, SQ, Q4W<\/span><\/p>\n<\/td>\n

\n

6.9<\/p>\n

<\/span><\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p=<\/span><\/i>0.0017;<\/span><\/p>\n

\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae
\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f
\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316)<\/span><\/p>\n<\/td>\n

\n

4.08<\/p>\n

<\/span><\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<<\/span><\/i>0.0001;<\/span><\/p>\n

\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae
\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f
\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316)<\/span><\/p>\n<\/td>\n

\n

0.58<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<<\/span><\/i>0.0001 ;<\/span><\/p>\n

\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae
\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121
\u986f\u8457\u8b8a\u5316)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

ASC47\u4f4e\u5291\u91cf 2<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

9 mg\/kg, SQ, Q4W<\/span><\/p>\n<\/td>\n

\n

5.7<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<<\/span><\/i>0.0001;<\/span><\/p>\n

\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae
\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f
\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316)<\/span><\/p>\n<\/td>\n

\n

3.32<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<<\/span><\/i>0.0001;<\/span><\/p>\n

\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae
\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f
\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316)<\/span><\/p>\n<\/td>\n

\n

0.44<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<<\/span><\/i>0.0001;<\/span><\/p>\n

\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae
\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f
\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg<\/span><\/p>\n

SQ, QD<\/span><\/p>\n<\/td>\n

\n

6.4<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p=<\/span><\/i>0.0001)<\/span><\/p>\n<\/td>\n

\n

3.90<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<<\/span><\/i>0.0001)<\/span><\/p>\n<\/td>\n

\n

0.61<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684
\u80a5\u80d6\u5c0f\u9f20\uff0c
p<0.0001<\/span><\/i>)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u8a3b\uff1a<\/i>\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21<\/p>\n

\u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002<\/p>\n

\u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c<\/p>\n

\n\n\n\n\n\n\n
\n

\u7d44\u5225<\/span><\/p>\n<\/td>\n

\n

\u7d66\u85e5<\/span><\/p>\n<\/td>\n

\n

\u7a7a\u8179\u8840\u7cd6 (mmoL\/L)<\/span><\/p>\n<\/td>\n

\n

\u81bd\u56fa\u9187 (mmoL\/L)<\/span><\/p>\n<\/td>\n

\n

LDL-C (mmoL\/L)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5291\u91cfASC47\u806f\u5408
\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6
\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

3 mg\/kg, SQ, Q4W<\/span><\/p>\n

+\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

5.3<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=0.0024<\/span><\/i>)<\/span><\/p>\n<\/td>\n

\n

2.65<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.0003)<\/span><\/p>\n<\/td>\n

\n

0.35<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.0045)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u5291\u91cfASC47\u806f\u5408
\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6
\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

ASC47, <\/span><\/p>\n

9 mg\/kg, SQ, Q4W<\/span><\/p>\n

+\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg, SQ, QD<\/span><\/p>\n<\/td>\n

\n

4.7<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp<\/span><\/i><0.0001)<\/span><\/p>\n<\/td>\n

\n

2.57<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.0002)<\/span><\/p>\n<\/td>\n

\n

0.36<\/span><\/p>\n

\u00a0<\/p>\n

(\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd
\u55ae\u85e5\uff0cp=<\/span><\/i>0.0055)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20<\/span><\/p>\n<\/td>\n

\n

\u53f8\u7f8e\u683c\u9b6f\u80bd<\/span><\/p>\n

30 nmol\/kg<\/span><\/p>\n

SQ, QD<\/span><\/p>\n<\/td>\n

\n

6.4<\/span><\/p>\n<\/td>\n

\n

3.90<\/span><\/p>\n<\/td>\n

\n

0.61<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/div>\n

\u8a3b\uff1a<\/i>\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21<\/p>\n

\u300c\u8102\u80aa\u9776\u5411\u7684 ASC47 \u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff0c\u9019\u4e9b\u6578\u64da\u4ee4\u4eba\u632f\u596e\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8102\u80aa\u9776\u5411\u7684ASC47\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\uff0c\u9019\u589e\u5f37\u4e86\u6211\u5011\u7684\u4fe1\u5fc3\uff0cASC47\u806f\u5408\u7642\u6cd5\u8207\u55ae\u7528\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\uff08incretin-based drugs\uff09\u76f8\u6bd4\uff0c\u53ef\u80fd\u6703\u5728\u81e8\u5e8a\u4e0a\u6709\u66f4\u597d\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u6548\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8aaa\uff0c\u300c\u8207apelin \u53d7\u9ad4\uff08APJ\uff09\u6fc0\u52d5\u5291\u5f15\u8d77\u809d\u9176\u5347\u9ad8\u4e0d\u540c\uff0c\u4f4e\u5291\u91cf ASC47 \u8207\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\u806f\u7528\u5f8c\uff0c\u809d\u9176\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002\u6211\u5011\u6b63\u5728\u540c\u6642\u63a8\u9032ASC47\u5e38\u898f\u5291\u91cf\u55ae\u85e5\u7642\u6cd5\u548c\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u7684\u7814\u767c\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u548c\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u300d<\/span><\/p>\n

<\/span><\/p>\n

\u6b4c\u79ae\u80a5\u80d6\u75c7\u7ba1\u7dda<\/span><\/b><\/p>\n

ASC47\u662f\u4e00\u6b3e\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590<\/a>\uff09\u671f\u4e2d\u6578\u64da\u5df2\u516c\u4f48\u3002ASC47\u7576\u524d\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u80a5\u80d6\u75c7\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\uff0cIIa\u671f\u7814\u7a76\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\u3002\u9664 ASC47 \u5916\uff0c\u6b4c\u79ae\u9084\u5728\u958b\u767c ASC30\uff0c\u8a72\u85e5\u5df2\u9032\u5165\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 ASC30 \u662f\u4e00\u7a2e\u5c0f\u5206\u5b50 GLP-1R\uff0c\u53ef\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u6216\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u3002ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247(NCT06680440<\/a>) \u548cASC30\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5291 (NCT06679959<\/a>)\u7576\u524d\u5747\u5728\u7f8e\u570b\u958b\u5c55Ib\u671f\u7528\u65bc\u80a5\u80d6\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u4f48\u3002<\/p>\n

\u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8<\/b><\/p>\n

\u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002<\/p>\n

\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com<\/a>\u3002<\/p>\n

\u8a73\u60c5\u5782\u8a62\uff1a<\/p>\n

Peter Vozzo<\/span><\/p>\n

ICR Healthcare<\/p>\n

443-231-0505 (\u7f8e\u570b)<\/p>\n

Peter.vozzo@westwicke.com<\/a><\/p>\n

\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a<\/p>\n

+86-181-0650-9129 (\u4e2d\u570b)<\/p>\n

pr@ascletis.com<\/a><\/p>\n

ir@ascletis.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

– \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e…<\/p>\n","protected":false},"author":16,"featured_media":199219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-284832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"\n\u6b4c\u79ae\u5ba3\u4f48\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"- \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC47\u4f4e\u5291\u91cf\u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0830 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\u3002- \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002- \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\u3002- \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002 \u9999\u6e2f2024\u5e7412\u670818\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\uff0c\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002 ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002 \u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u7684\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u70ba21\u5929\u3002\u6b64\u5916\uff0cASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7576\u524d\u5291\u91cf\u5df2\u905e\u589e\u81f390 mg\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\uff0c\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\uff08\u93c8\u63a5\uff09\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u5728\u6b64\u524d\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5e38\u898f\u5291\u91cfASC47\uff0845 mg\/kg, \u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u55ae\u85e5\u986f\u793a\u51fa\u7e3d\u9ad4\u91cd\u4e0b\u964d24.6%\u7684\u7642\u6548\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08\u4e0b\u964d23.1%\uff0c30 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6548\u76f8\u4f3c\u3002\u5e38\u898f\u5291\u91cfASC47\u4f7f\u808c\u8089\u7e3d\u91cf\u589e\u52a05.8%\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u4f7f\u808c\u8089\u7e3d\u91cf\u6e1b\u5c119.3%\uff08\u93c8\u63a5\uff09\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u8a73\u7d30\u81e8\u5e8a\u524d\u6578\u64da \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\/kg\u62169 mg\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff08\u8868 1\uff09\u3002 \u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316 \u808c\u8089\u7e3d\u91cf\/\u7e3d\u9ad4\u91cd \u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09 \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 66.0\u00a0% 308 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 46.6\u00a0% 378 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +5.54\u00a0% 48.6\u00a0% 388 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W -1.55\u00a0% 52.1\u00a0% 348 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD -23.1\u00a0% 57.2\u00a0% 211 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -36.2% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 251 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0385) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -35.9% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 267 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\uff08\u88681\uff09\u3002 \u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002 \u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 ALT\u00a0(U\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 31.5 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 234 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 182 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 159 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 32.9 \uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316\uff09 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 54.1 \u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316 ) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 70.0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002 \u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\/L) \u81bd\u56fa\u9187\u00a0(mmoL\/L) LDL-C (mmoL\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 7.5 3.53 0.50 \u80a5\u80d6\u5c0f\u9f20 \u00a0\u5b89\u6170\u5291\u00a0 9.2 6.98 1.41 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 6.9 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0017; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 4.08 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.58 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001 ; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 5.7 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 3.32 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.44 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0001) 3.90 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) 0.61 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002 \u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6 (mmoL\/L) \u81bd\u56fa\u9187 (mmoL\/L) LDL-C (mmoL\/L) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 5.3 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0024) 2.65 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0003) 0.35 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0045) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 4.7 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 2.57 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0002) 0.36 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0055) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 3.90 0.61 \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u300c\u8102\u80aa\u9776\u5411\u7684 ASC47 \u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff0c\u9019\u4e9b\u6578\u64da\u4ee4\u4eba\u632f\u596e\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8102\u80aa\u9776\u5411\u7684ASC47\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\uff0c\u9019\u589e\u5f37\u4e86\u6211\u5011\u7684\u4fe1\u5fc3\uff0cASC47\u806f\u5408\u7642\u6cd5\u8207\u55ae\u7528\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\uff08incretin-based drugs\uff09\u76f8\u6bd4\uff0c\u53ef\u80fd\u6703\u5728\u81e8\u5e8a\u4e0a\u6709\u66f4\u597d\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u6548\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8aaa\uff0c\u300c\u8207apelin \u53d7\u9ad4\uff08APJ\uff09\u6fc0\u52d5\u5291\u5f15\u8d77\u809d\u9176\u5347\u9ad8\u4e0d\u540c\uff0c\u4f4e\u5291\u91cf ASC47 \u8207\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\u806f\u7528\u5f8c\uff0c\u809d\u9176\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002\u6211\u5011\u6b63\u5728\u540c\u6642\u63a8\u9032ASC47\u5e38\u898f\u5291\u91cf\u55ae\u85e5\u7642\u6cd5\u548c\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u7684\u7814\u767c\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u548c\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u300d \u6b4c\u79ae\u80a5\u80d6\u75c7\u7ba1\u7dda ASC47\u662f\u4e00\u6b3e\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u671f\u4e2d\u6578\u64da\u5df2\u516c\u4f48\u3002ASC47\u7576\u524d\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u80a5\u80d6\u75c7\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\uff0cIIa\u671f\u7814\u7a76\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\u3002\u9664 ASC47 \u5916\uff0c\u6b4c\u79ae\u9084\u5728\u958b\u767c ASC30\uff0c\u8a72\u85e5\u5df2\u9032\u5165\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 ASC30 \u662f\u4e00\u7a2e\u5c0f\u5206\u5b50 GLP-1R\uff0c\u53ef\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u6216\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u3002ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247(NCT06680440) \u548cASC30\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5291 (NCT06679959)\u7576\u524d\u5747\u5728\u7f8e\u570b\u958b\u5c55Ib\u671f\u7528\u65bc\u80a5\u80d6\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u4f48\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 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content=\"\u6b4c\u79ae\u5ba3\u4f48\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"- \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC47\u4f4e\u5291\u91cf\u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0830 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\u3002- \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002- \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\u3002- \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002 \u9999\u6e2f2024\u5e7412\u670818\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\uff0c\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002 ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002 \u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u7684\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u70ba21\u5929\u3002\u6b64\u5916\uff0cASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7576\u524d\u5291\u91cf\u5df2\u905e\u589e\u81f390 mg\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\uff0c\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\uff08\u93c8\u63a5\uff09\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u5728\u6b64\u524d\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5e38\u898f\u5291\u91cfASC47\uff0845 mg\/kg, \u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u55ae\u85e5\u986f\u793a\u51fa\u7e3d\u9ad4\u91cd\u4e0b\u964d24.6%\u7684\u7642\u6548\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08\u4e0b\u964d23.1%\uff0c30 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6548\u76f8\u4f3c\u3002\u5e38\u898f\u5291\u91cfASC47\u4f7f\u808c\u8089\u7e3d\u91cf\u589e\u52a05.8%\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u4f7f\u808c\u8089\u7e3d\u91cf\u6e1b\u5c119.3%\uff08\u93c8\u63a5\uff09\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u8a73\u7d30\u81e8\u5e8a\u524d\u6578\u64da \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\/kg\u62169 mg\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff08\u8868 1\uff09\u3002 \u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316 \u808c\u8089\u7e3d\u91cf\/\u7e3d\u9ad4\u91cd \u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09 \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 66.0\u00a0% 308 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 46.6\u00a0% 378 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +5.54\u00a0% 48.6\u00a0% 388 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W -1.55\u00a0% 52.1\u00a0% 348 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD -23.1\u00a0% 57.2\u00a0% 211 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -36.2% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 251 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0385) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -35.9% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 267 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\uff08\u88681\uff09\u3002 \u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002 \u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 ALT\u00a0(U\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 31.5 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 234 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 182 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 159 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 32.9 \uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316\uff09 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 54.1 \u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316 ) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 70.0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002 \u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\/L) \u81bd\u56fa\u9187\u00a0(mmoL\/L) LDL-C (mmoL\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 7.5 3.53 0.50 \u80a5\u80d6\u5c0f\u9f20 \u00a0\u5b89\u6170\u5291\u00a0 9.2 6.98 1.41 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 6.9 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0017; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 4.08 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.58 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001 ; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 5.7 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 3.32 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.44 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0001) 3.90 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) 0.61 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002 \u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6 (mmoL\/L) \u81bd\u56fa\u9187 (mmoL\/L) LDL-C (mmoL\/L) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 5.3 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0024) 2.65 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0003) 0.35 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0045) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 4.7 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 2.57 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0002) 0.36 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0055) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 3.90 0.61 \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u300c\u8102\u80aa\u9776\u5411\u7684 ASC47 \u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff0c\u9019\u4e9b\u6578\u64da\u4ee4\u4eba\u632f\u596e\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8102\u80aa\u9776\u5411\u7684ASC47\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\uff0c\u9019\u589e\u5f37\u4e86\u6211\u5011\u7684\u4fe1\u5fc3\uff0cASC47\u806f\u5408\u7642\u6cd5\u8207\u55ae\u7528\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\uff08incretin-based drugs\uff09\u76f8\u6bd4\uff0c\u53ef\u80fd\u6703\u5728\u81e8\u5e8a\u4e0a\u6709\u66f4\u597d\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u6548\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8aaa\uff0c\u300c\u8207apelin \u53d7\u9ad4\uff08APJ\uff09\u6fc0\u52d5\u5291\u5f15\u8d77\u809d\u9176\u5347\u9ad8\u4e0d\u540c\uff0c\u4f4e\u5291\u91cf ASC47 \u8207\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\u806f\u7528\u5f8c\uff0c\u809d\u9176\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002\u6211\u5011\u6b63\u5728\u540c\u6642\u63a8\u9032ASC47\u5e38\u898f\u5291\u91cf\u55ae\u85e5\u7642\u6cd5\u548c\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u7684\u7814\u767c\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u548c\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u300d \u6b4c\u79ae\u80a5\u80d6\u75c7\u7ba1\u7dda ASC47\u662f\u4e00\u6b3e\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u671f\u4e2d\u6578\u64da\u5df2\u516c\u4f48\u3002ASC47\u7576\u524d\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u80a5\u80d6\u75c7\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\uff0cIIa\u671f\u7814\u7a76\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\u3002\u9664 ASC47 \u5916\uff0c\u6b4c\u79ae\u9084\u5728\u958b\u767c ASC30\uff0c\u8a72\u85e5\u5df2\u9032\u5165\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 ASC30 \u662f\u4e00\u7a2e\u5c0f\u5206\u5b50 GLP-1R\uff0c\u53ef\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u6216\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u3002ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247(NCT06680440) \u548cASC30\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5291 (NCT06679959)\u7576\u524d\u5747\u5728\u7f8e\u570b\u958b\u5c55Ib\u671f\u7528\u65bc\u80a5\u80d6\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u4f48\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter Vozzo ICR Healthcare 443-231-0505 (\u7f8e\u570b) Peter.vozzo@westwicke.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a +86-181-0650-9129 (\u4e2d\u570b) pr@ascletis.com ir@ascletis.com\" \/>\n<meta property=\"og:url\" content=\"https:\/\/pingtungtimes.com.tw\/?p=284832\" \/>\n<meta property=\"og:site_name\" content=\"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/pingtungnews\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-18T14:02:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png\" \/>\n<meta name=\"author\" content=\"\u7f8e\u901a\u793e\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" 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- \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=284832#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=284832#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/wp-content\\\/uploads\\\/2023\\\/02\\\/logo-150.png\",\"datePublished\":\"2024-12-18T14:02:00+00:00\",\"description\":\"- \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC47\u4f4e\u5291\u91cf\u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\\\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0830 nmol\\\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\u3002- \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002- \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\u3002- \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002 \u9999\u6e2f2024\u5e7412\u670818\u65e5 \\\/\u7f8e\u901a\u793e\\\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\uff0c\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002 ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002 \u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u7684\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u70ba21\u5929\u3002\u6b64\u5916\uff0cASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7576\u524d\u5291\u91cf\u5df2\u905e\u589e\u81f390 mg\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\uff0c\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\uff08\u93c8\u63a5\uff09\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u5728\u6b64\u524d\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5e38\u898f\u5291\u91cfASC47\uff0845 mg\\\/kg, \u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u55ae\u85e5\u986f\u793a\u51fa\u7e3d\u9ad4\u91cd\u4e0b\u964d24.6%\u7684\u7642\u6548\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08\u4e0b\u964d23.1%\uff0c30 nmol\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6548\u76f8\u4f3c\u3002\u5e38\u898f\u5291\u91cfASC47\u4f7f\u808c\u8089\u7e3d\u91cf\u589e\u52a05.8%\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u4f7f\u808c\u8089\u7e3d\u91cf\u6e1b\u5c119.3%\uff08\u93c8\u63a5\uff09\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u8a73\u7d30\u81e8\u5e8a\u524d\u6578\u64da \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\\\/kg\u62169 mg\\\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\\\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff08\u8868 1\uff09\u3002 \u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316 \u808c\u8089\u7e3d\u91cf\\\/\u7e3d\u9ad4\u91cd \u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09 \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 66.0\u00a0% 308 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 46.6\u00a0% 378 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\\\/kg, SQ, Q4W +5.54\u00a0% 48.6\u00a0% 388 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\\\/kg, SQ, Q4W -1.55\u00a0% 52.1\u00a0% 348 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg SQ, QD -23.1\u00a0% 57.2\u00a0% 211 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\\\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD -36.2% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 251 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0385) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\\\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD -35.9% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 267 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\\\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\uff08\u88681\uff09\u3002 \u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002 \u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 ALT\u00a0(U\\\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 31.5 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 234 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\\\/kg, SQ, Q4W 182 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\\\/kg, SQ, Q4W 159 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD 32.9 \uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316\uff09 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\\\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD 54.1 \u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316 ) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\\\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD 70.0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002 \u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\\\/L) \u81bd\u56fa\u9187\u00a0(mmoL\\\/L) LDL-C (mmoL\\\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 7.5 3.53 0.50 \u80a5\u80d6\u5c0f\u9f20 \u00a0\u5b89\u6170\u5291\u00a0 9.2 6.98 1.41 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\\\/kg, SQ, Q4W 6.9 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0017; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 4.08 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.58 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001 ; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\\\/kg, SQ, Q4W 5.7 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 3.32 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.44 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg SQ, QD 6.4 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0001) 3.90 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) 0.61 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002 \u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6 (mmoL\\\/L) \u81bd\u56fa\u9187 (mmoL\\\/L) LDL-C (mmoL\\\/L) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\\\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD 5.3 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0024) 2.65 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0003) 0.35 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0045) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\\\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg, SQ, QD 4.7 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 2.57 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0002) 0.36 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0055) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\\\/kg SQ, QD 6.4 3.90 0.61 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\/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u6b4c\u79ae\u5ba3\u4f48\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","description":"- \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC47\u4f4e\u5291\u91cf\u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0830 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\u3002- \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002- \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\u3002- \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002 \u9999\u6e2f2024\u5e7412\u670818\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\uff0c\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002 ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002 \u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u7684\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u70ba21\u5929\u3002\u6b64\u5916\uff0cASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7576\u524d\u5291\u91cf\u5df2\u905e\u589e\u81f390 mg\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\uff0c\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\uff08\u93c8\u63a5\uff09\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u5728\u6b64\u524d\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5e38\u898f\u5291\u91cfASC47\uff0845 mg\/kg, \u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u55ae\u85e5\u986f\u793a\u51fa\u7e3d\u9ad4\u91cd\u4e0b\u964d24.6%\u7684\u7642\u6548\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08\u4e0b\u964d23.1%\uff0c30 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6548\u76f8\u4f3c\u3002\u5e38\u898f\u5291\u91cfASC47\u4f7f\u808c\u8089\u7e3d\u91cf\u589e\u52a05.8%\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u4f7f\u808c\u8089\u7e3d\u91cf\u6e1b\u5c119.3%\uff08\u93c8\u63a5\uff09\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u8a73\u7d30\u81e8\u5e8a\u524d\u6578\u64da \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\/kg\u62169 mg\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff08\u8868 1\uff09\u3002 \u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316 \u808c\u8089\u7e3d\u91cf\/\u7e3d\u9ad4\u91cd \u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09 \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 66.0\u00a0% 308 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 46.6\u00a0% 378 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +5.54\u00a0% 48.6\u00a0% 388 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W -1.55\u00a0% 52.1\u00a0% 348 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD -23.1\u00a0% 57.2\u00a0% 211 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -36.2% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 251 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0385) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -35.9% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 267 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\uff08\u88681\uff09\u3002 \u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002 \u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 ALT\u00a0(U\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 31.5 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 234 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 182 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 159 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 32.9 \uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316\uff09 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 54.1 \u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316 ) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 70.0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002 \u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\/L) \u81bd\u56fa\u9187\u00a0(mmoL\/L) LDL-C (mmoL\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 7.5 3.53 0.50 \u80a5\u80d6\u5c0f\u9f20 \u00a0\u5b89\u6170\u5291\u00a0 9.2 6.98 1.41 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 6.9 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0017; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 4.08 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.58 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001 ; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 5.7 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 3.32 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.44 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0001) 3.90 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) 0.61 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002 \u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6 (mmoL\/L) \u81bd\u56fa\u9187 (mmoL\/L) LDL-C (mmoL\/L) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 5.3 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0024) 2.65 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0003) 0.35 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0045) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 4.7 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 2.57 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0002) 0.36 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0055) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 3.90 0.61 \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u300c\u8102\u80aa\u9776\u5411\u7684 ASC47 \u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff0c\u9019\u4e9b\u6578\u64da\u4ee4\u4eba\u632f\u596e\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8102\u80aa\u9776\u5411\u7684ASC47\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\uff0c\u9019\u589e\u5f37\u4e86\u6211\u5011\u7684\u4fe1\u5fc3\uff0cASC47\u806f\u5408\u7642\u6cd5\u8207\u55ae\u7528\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\uff08incretin-based drugs\uff09\u76f8\u6bd4\uff0c\u53ef\u80fd\u6703\u5728\u81e8\u5e8a\u4e0a\u6709\u66f4\u597d\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u6548\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8aaa\uff0c\u300c\u8207apelin \u53d7\u9ad4\uff08APJ\uff09\u6fc0\u52d5\u5291\u5f15\u8d77\u809d\u9176\u5347\u9ad8\u4e0d\u540c\uff0c\u4f4e\u5291\u91cf ASC47 \u8207\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\u806f\u7528\u5f8c\uff0c\u809d\u9176\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002\u6211\u5011\u6b63\u5728\u540c\u6642\u63a8\u9032ASC47\u5e38\u898f\u5291\u91cf\u55ae\u85e5\u7642\u6cd5\u548c\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u7684\u7814\u767c\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u548c\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u300d \u6b4c\u79ae\u80a5\u80d6\u75c7\u7ba1\u7dda ASC47\u662f\u4e00\u6b3e\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u671f\u4e2d\u6578\u64da\u5df2\u516c\u4f48\u3002ASC47\u7576\u524d\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u80a5\u80d6\u75c7\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\uff0cIIa\u671f\u7814\u7a76\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\u3002\u9664 ASC47 \u5916\uff0c\u6b4c\u79ae\u9084\u5728\u958b\u767c ASC30\uff0c\u8a72\u85e5\u5df2\u9032\u5165\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 ASC30 \u662f\u4e00\u7a2e\u5c0f\u5206\u5b50 GLP-1R\uff0c\u53ef\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u6216\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u3002ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247(NCT06680440) \u548cASC30\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5291 (NCT06679959)\u7576\u524d\u5747\u5728\u7f8e\u570b\u958b\u5c55Ib\u671f\u7528\u65bc\u80a5\u80d6\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u4f48\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter Vozzo ICR Healthcare 443-231-0505 (\u7f8e\u570b) Peter.vozzo@westwicke.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a +86-181-0650-9129 (\u4e2d\u570b) pr@ascletis.com ir@ascletis.com","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pingtungtimes.com.tw\/?p=284832","og_locale":"zh_TW","og_type":"article","og_title":"\u6b4c\u79ae\u5ba3\u4f48\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u81e8\u5e8a\u524d\u6a21\u578b\u4e2d\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7684\u6e1b\u91cd\u6548\u679c - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","og_description":"- \u5728\u4e00\u9805\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7684\u982d\u5c0d\u982d\u7814\u7a76\u4e2d\uff0cASC47\u4f4e\u5291\u91cf\u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u986f\u793a\u51fa\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0830 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u7684\u6e1b\u91cd\u6548\u679c\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\u3002- \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002- \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\u3002- \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002 \u9999\u6e2f2024\u5e7412\u670818\u65e5 \/\u7f8e\u901a\u793e\/ -- \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u5ba3\u4f48\uff0c\u540c\u985e\u9996\u5275\u6cbb\u7642\u80a5\u80d6\u75c7\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u5019\u9078\u85e5\u7269ASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u5408\u7528\u85e5\u5728\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\uff08DIO\uff09\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7642\u6548\u3002 ASC47\u662f\u6b4c\u79ae\u81ea\u4e3b\u7814\u767c\u7684\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002ASC47\u5177\u6709\u7368\u7279\u7684\u5dee\u7570\u5316\u7279\u6027\uff0c\u80fd\u5920\u9776\u5411\u8102\u80aa\uff0c\u5f9e\u800c\u5728\u8102\u80aa\u7d44\u7e54\u4e2d\u7522\u751f\u5291\u91cf\u4f9d\u8cf4\u6027\u7684\u9ad8\u85e5\u7269\u6fc3\u5ea6\u3002 \u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u7684\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0c\u76ae\u4e0b\u6ce8\u5c04ASC47\u7684\u534a\u8870\u671f\u70ba21\u5929\u3002\u6b64\u5916\uff0cASC47\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u7576\u524d\u5291\u91cf\u5df2\u905e\u589e\u81f390 mg\uff0c\u7121\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u767c\u751f\uff0c\u4e5f\u672a\u767c\u751f\u56e0\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u800c\u5c0e\u81f4\u7684\u505c\u85e5\u3002\u5927\u591a\u6578AE\u70ba\u8f15\u5ea6\uff081\u7d1a\uff09\u3002\u6c92\u6709\u5831\u544a\u80c3\u8178\u9053\u548c\u5fc3\u81dfAE\uff0c\u6c92\u6709\u5831\u544a\u809d\u9176\u7570\u5e38\uff08\u93c8\u63a5\uff09\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u5728\u6b64\u524d\u7684\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u5e38\u898f\u5291\u91cfASC47\uff0845 mg\/kg, \u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u5169\u9031\u4e00\u6b21\uff09\u55ae\u85e5\u986f\u793a\u51fa\u7e3d\u9ad4\u91cd\u4e0b\u964d24.6%\u7684\u7642\u6548\uff0c\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff08\u4e0b\u964d23.1%\uff0c30 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6548\u76f8\u4f3c\u3002\u5e38\u898f\u5291\u91cfASC47\u4f7f\u808c\u8089\u7e3d\u91cf\u589e\u52a05.8%\uff0c\u800c\u53f8\u7f8e\u683c\u9b6f\u80bd\u4f7f\u808c\u8089\u7e3d\u91cf\u6e1b\u5c119.3%\uff08\u93c8\u63a5\uff09\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u8a73\u7d30\u81e8\u5e8a\u524d\u6578\u64da \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\/kg\u62169 mg\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff08\u8868 1\uff09\u3002 \u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316 \u808c\u8089\u7e3d\u91cf\/\u7e3d\u9ad4\u91cd \u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09 \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 66.0\u00a0% 308 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 46.6\u00a0% 378 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +5.54\u00a0% 48.6\u00a0% 388 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W -1.55\u00a0% 52.1\u00a0% 348 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD -23.1\u00a0% 57.2\u00a0% 211 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -36.2% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 251 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0385) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -35.9% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 267 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\uff08\u88681\uff09\u3002 \u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002 \u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 ALT\u00a0(U\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 31.5 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 234 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 182 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 159 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 32.9 \uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316\uff09 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 54.1 \u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316 ) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 70.0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002 \u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\/L) \u81bd\u56fa\u9187\u00a0(mmoL\/L) LDL-C (mmoL\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 7.5 3.53 0.50 \u80a5\u80d6\u5c0f\u9f20 \u00a0\u5b89\u6170\u5291\u00a0 9.2 6.98 1.41 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 6.9 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0017; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 4.08 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.58 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001 ; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 5.7 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 3.32 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.44 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0001) 3.90 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) 0.61 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002 \u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6 (mmoL\/L) \u81bd\u56fa\u9187 (mmoL\/L) LDL-C (mmoL\/L) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 5.3 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0024) 2.65 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0003) 0.35 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0045) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 4.7 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 2.57 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0002) 0.36 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0055) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 3.90 0.61 \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u300c\u8102\u80aa\u9776\u5411\u7684 ASC47 \u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff0c\u9019\u4e9b\u6578\u64da\u4ee4\u4eba\u632f\u596e\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8102\u80aa\u9776\u5411\u7684ASC47\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\uff0c\u9019\u589e\u5f37\u4e86\u6211\u5011\u7684\u4fe1\u5fc3\uff0cASC47\u806f\u5408\u7642\u6cd5\u8207\u55ae\u7528\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\uff08incretin-based drugs\uff09\u76f8\u6bd4\uff0c\u53ef\u80fd\u6703\u5728\u81e8\u5e8a\u4e0a\u6709\u66f4\u597d\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u6548\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8aaa\uff0c\u300c\u8207apelin \u53d7\u9ad4\uff08APJ\uff09\u6fc0\u52d5\u5291\u5f15\u8d77\u809d\u9176\u5347\u9ad8\u4e0d\u540c\uff0c\u4f4e\u5291\u91cf ASC47 \u8207\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\u806f\u7528\u5f8c\uff0c\u809d\u9176\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002\u6211\u5011\u6b63\u5728\u540c\u6642\u63a8\u9032ASC47\u5e38\u898f\u5291\u91cf\u55ae\u85e5\u7642\u6cd5\u548c\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u7684\u7814\u767c\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u548c\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u300d \u6b4c\u79ae\u80a5\u80d6\u75c7\u7ba1\u7dda ASC47\u662f\u4e00\u6b3e\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u671f\u4e2d\u6578\u64da\u5df2\u516c\u4f48\u3002ASC47\u7576\u524d\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u80a5\u80d6\u75c7\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\uff0cIIa\u671f\u7814\u7a76\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\u3002\u9664 ASC47 \u5916\uff0c\u6b4c\u79ae\u9084\u5728\u958b\u767c ASC30\uff0c\u8a72\u85e5\u5df2\u9032\u5165\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 ASC30 \u662f\u4e00\u7a2e\u5c0f\u5206\u5b50 GLP-1R\uff0c\u53ef\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u6216\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u3002ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247(NCT06680440) \u548cASC30\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5291 (NCT06679959)\u7576\u524d\u5747\u5728\u7f8e\u570b\u958b\u5c55Ib\u671f\u7528\u65bc\u80a5\u80d6\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u4f48\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 \u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3GMP\u751f\u7522\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u805a\u7126\u5169\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u4ee3\u8b1d\u6027\u75be\u75c5\u548c\u75c5\u6bd2\u6027\u75be\u75c5\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6b4c\u79ae\u7684\u7814\u767c\u7ba1\u7dda\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269\u3002 \u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1awww.ascletis.com\u3002 \u8a73\u60c5\u5782\u8a62\uff1a Peter Vozzo ICR Healthcare 443-231-0505 (\u7f8e\u570b) Peter.vozzo@westwicke.com \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8PR\u548cIR\u5718\u968a +86-181-0650-9129 (\u4e2d\u570b) pr@ascletis.com ir@ascletis.com","og_url":"https:\/\/pingtungtimes.com.tw\/?p=284832","og_site_name":"\u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831","article_publisher":"https:\/\/www.facebook.com\/pingtungnews","article_published_time":"2024-12-18T14:02:00+00:00","og_image":[{"url":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","type":"","width":"","height":""}],"author":"\u7f8e\u901a\u793e","twitter_card":"summary_large_image","twitter_image":"https:\/\/pingtungtimes.com.tw\/wp-content\/uploads\/2023\/02\/logo-150.png","twitter_misc":{"\u4f5c\u8005:":"\u7f8e\u901a\u793e","\u9810\u4f30\u95b1\u8b80\u6642\u9593":"2 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\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728DIO\u5c0f\u9f20\u4e2d\u7684\u982d\u5c0d\u982d\u7814\u7a76\u65e8\u5728\u5c07\u4f4e\u983b\u6ce8\u5c04\uff08\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u4f4e\u5291\u91cfASC47\uff083 mg\/kg\u62169 mg\/kg\uff09\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u7642\u6cd5\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0830 nmol\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u65e5\u4e00\u6b21\uff09\u9032\u884c\u5c0d\u6bd4\u3002\u4f4e\u5291\u91cfASC47 \u806f\u5408\u7528\u85e5 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff0c\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\uff0c30 nmol\/kg, \u76ae\u4e0b\u6ce8\u5c04, \u6bcf\u65e5\u4e00\u6b21\uff09\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\uff0c\u806f\u5408\u7528\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d36.2%\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u4f7f\u9ad4\u91cd\u4e0b\u964d23.1%\uff0c\u806f\u5408\u7528\u85e5\u6bd4\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff08\u8868 1\uff09\u3002 \u88681. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u986f\u793a\u512a\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7684\u6e1b\u91cd\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7e3d\u9ad4\u91cd\u76f8\u5c0d\u57fa\u7dda\u7684\u8b8a\u5316 \u808c\u8089\u7e3d\u91cf\/\u7e3d\u9ad4\u91cd \u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\uff08kCal\uff09 \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 66.0\u00a0% 308 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 +8.53\u00a0% 46.6\u00a0% 378 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +5.54\u00a0% 48.6\u00a0% 388 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W -1.55\u00a0% 52.1\u00a0% 348 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD -23.1\u00a0% 57.2\u00a0% 211 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -36.2% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 251 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0385) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD -35.9% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 68.8% (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0001) 267 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u6839\u64da\u9ad4\u8868\u9762\u7a4d\u63db\u7b97\uff0c\u5c0f\u9f20\u9ad4\u5167 ASC47 \u4f4e\u5291\u91cf 1\uff08ASC47\uff0c3 mg\/kg\uff0c\u76ae\u4e0b\u6ce8\u5c04\uff0c\u6bcf\u56db\u9031\u4e00\u6b21\uff09\u7684\u4eba\u9ad4\u7b49\u6548\u5291\u91cf\u9810\u8a08\u5927\u7d04\u70ba 20 mg\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u504f\u9ad8\u53d7\u8a66\u8005 I \u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\u7576\u524d\u905e\u589e\u81f390 mg\uff0c\u671f\u4e2d\u6578\u64da\u986f\u793a\uff0cASC47 \u76ae\u4e0b\u6ce8\u5c04\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u66f4\u9ad8\u5291\u91cf\u7684\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\u3002 \u4f4e\u5291\u91cfASC47\u8207\u53f8\u7f8e\u683c\u9b6f\u80bd\u806f\u7528\u5c07\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u6062\u5fa9\u81f3\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u7684\u6c34\u5e73\u3002\u6cbb\u7642\u7d50\u675f\u6642\uff0c\u63a5\u53d7\u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u808c\u8089\u7e3d\u91cf\u5360\u7e3d\u9ad4\u91cd\u6bd4\u4f8b\uff0868.8%\uff09\u8207\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0866.0%\uff09\u76f8\u4f3c\uff0c\u610f\u5473\u8457\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\u3002\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7121\u6cd5\u6062\u5fa9\u80a5\u80d6\u5c0f\u9f20\u7684\u8eab\u9ad4\u6210\u5206\u81f3\u5065\u5eb7\u6c34\u5e73\uff08\u88681\uff09\u3002 \u6cbb\u7642\u7d50\u675f\u6642\uff0c \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\u7684\u7d2f\u8a08\u71b1\u91cf\u651d\u5165\u91cf\u986f\u8457\u9ad8\u65bc\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u7642\u6cd5\u7d44\u80a5\u80d6\u5c0f\u9f20\uff08\u8868 1\uff09\uff0c\u8aaa\u660eASC47\u7684\u4f5c\u7528\u6a5f\u5236\u6709\u5225\u65bc\u80f0\u9ad8\u8840\u7cd6\u7d20\u985e\u85e5\u7269\u3002 \u4f4e\u5291\u91cfASC47\u806f\u5408\u53f8\u7f8e\u683c\u9b6f\u80bd\u7642\u6cd5\u5728\u80a5\u80d6\u5c0f\u9f20\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u8207\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u7b49\u809d\u9176\u6c34\u5e73\u5448\u73fe\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88682\uff09\u3002 \u88682. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u80a5\u80d6\u5c0f\u9f20\u5b89\u6170\u5291\u6cbb\u7642\u7d44ALT\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 ALT\u00a0(U\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 31.5 \u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 234 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 182 ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 159 \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 32.9 \uff08\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316\uff09 \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 54.1 \u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b \u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316 ) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 70.0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001\uff1b\u5c0d\u6bd4\u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20\u548c\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u8207\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u76f8\u6bd4\uff0c\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u5747\u4f7f\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\uff08\u88683\uff09\u3002 \u88683. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7d44\u5c0d\u6bd4\u5b89\u6170\u5291\u7d44\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6\u00a0(mmoL\/L) \u81bd\u56fa\u9187\u00a0(mmoL\/L) LDL-C (mmoL\/L) \u5065\u5eb7\u975e\u80a5\u80d6\u5c0f\u9f20 \u5b89\u6170\u5291 7.5 3.53 0.50 \u80a5\u80d6\u5c0f\u9f20 \u00a0\u5b89\u6170\u5291\u00a0 9.2 6.98 1.41 ASC47\u4f4e\u5291\u91cf 1 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W 6.9 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0017; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 4.08 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.58 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001 ; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) ASC47\u4f4e\u5291\u91cf 2 \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W 5.7 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 3.32 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) 0.44 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001; \u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0c\u7121\u986f\u8457\u8b8a\u5316) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp=0.0001) 3.90 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) 0.61 \u00a0 (\u5c0d\u6bd4\u5b89\u6170\u5291\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\uff0cp<0.0001) \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u63a5\u53d7\u5169\u7a2e\u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u7684\u80a5\u80d6\u5c0f\u9f20\u7684\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u5747\u6bd4\u63a5\u53d7\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u66f4\u591a\u7684\u4e0b\u964d\uff08\u88684\uff09\u3002 \u8868 4. \u4f4e\u5291\u91cfASC47\u806f\u5408\u7642\u6cd5\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u986f\u793a\u51fa\u66f4\u512a\u7684\u964d\u7a7a\u8179\u8840\u7cd6\u3001\u81bd\u56fa\u9187\u548cLDL-C\u6548\u679c \u7d44\u5225 \u7d66\u85e5 \u7a7a\u8179\u8840\u7cd6 (mmoL\/L) \u81bd\u56fa\u9187 (mmoL\/L) LDL-C (mmoL\/L) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e51\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 3 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 5.3 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0024) 2.65 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0003) 0.35 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0045) \u4f4e\u5291\u91cfASC47\u806f\u5408\u7528\u85e52\u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 ASC47, 9 mg\/kg, SQ, Q4W +\u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg, SQ, QD 4.7 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp<0.0001) 2.57 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0002) 0.36 \u00a0 (\u5c0d\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\uff0cp=0.0055) \u53f8\u7f8e\u683c\u9b6f\u80bd \u6cbb\u7642\u7684\u80a5\u80d6\u5c0f\u9f20 \u53f8\u7f8e\u683c\u9b6f\u80bd 30 nmol\/kg SQ, QD 6.4 3.90 0.61 \u8a3b\uff1a\u6cbb\u7642\u9031\u671f\uff1a28\u5929\uff1b\u80a5\u80d6\u5c0f\u9f20\uff1a\u98f2\u98df\u8a98\u5c0e\u80a5\u80d6\u7684\u5c0f\u9f20\uff1bSQ\uff1a\u76ae\u4e0b\u6ce8\u5c04\uff1bQD\uff1a\u6bcf\u65e5\u4e00\u6b21\uff1bQ4W\uff1a\u6bcf\u56db\u9031\u4e00\u6b21 \u300c\u8102\u80aa\u9776\u5411\u7684 ASC47 \u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u6bd4\u53f8\u7f8e\u683c\u9b6f\u80bd\u55ae\u85e5\u591a\u6e1b\u91cd56.7%\uff0c\u9019\u4e9b\u6578\u64da\u4ee4\u4eba\u632f\u596e\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u81e8\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8102\u80aa\u9776\u5411\u7684ASC47\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u5be6\u73fe\u4e86\u5065\u5eb7\u6e1b\u91cd\uff0c\u9019\u589e\u5f37\u4e86\u6211\u5011\u7684\u4fe1\u5fc3\uff0cASC47\u806f\u5408\u7642\u6cd5\u8207\u55ae\u7528\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\uff08incretin-based drugs\uff09\u76f8\u6bd4\uff0c\u53ef\u80fd\u6703\u5728\u81e8\u5e8a\u4e0a\u6709\u66f4\u597d\u7684\u6e1b\u91cd\u4e0d\u6e1b\u808c\u7684\u6548\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8aaa\uff0c\u300c\u8207apelin \u53d7\u9ad4\uff08APJ\uff09\u6fc0\u52d5\u5291\u5f15\u8d77\u809d\u9176\u5347\u9ad8\u4e0d\u540c\uff0c\u4f4e\u5291\u91cf ASC47 \u8207\u8178\u4fc3\u80f0\u7d20\u985e\u85e5\u7269\u806f\u7528\u5f8c\uff0c\u809d\u9176\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u964d\u4f4e\u3002\u6211\u5011\u6b63\u5728\u540c\u6642\u63a8\u9032ASC47\u5e38\u898f\u5291\u91cf\u55ae\u85e5\u7642\u6cd5\u548c\u4f4e\u5291\u91cf\u806f\u5408\u7642\u6cd5\u7684\u7814\u767c\uff0c\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\u75c7\u548c\u5176\u4ed6\u4ee3\u8b1d\u6027\u75be\u75c5\u3002\u300d \u6b4c\u79ae\u80a5\u80d6\u75c7\u7ba1\u7dda ASC47\u662f\u4e00\u6b3e\u8102\u80aa\u9776\u5411\u3001\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u7684\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u9078\u64c7\u6027\u5c0f\u5206\u5b50\u6fc0\u52d5\u5291\u3002\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u7684LDL-C\u504f\u9ad8\u53d7\u8a66\u8005I\u671f\u55ae\u5291\u91cf\u905e\u589e\uff08SAD\uff09\u7814\u7a76\uff08NCT06427590\uff09\u671f\u4e2d\u6578\u64da\u5df2\u516c\u4f48\u3002ASC47\u7576\u524d\u6b63\u5728\u6fb3\u5927\u5229\u4e9e\u9032\u884c\u80a5\u80d6\u75c7\u60a3\u8005\u81e8\u5e8a\u8a66\u9a57\uff0cIIa\u671f\u7814\u7a76\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u516c\u4f48\u3002\u9664 ASC47 \u5916\uff0c\u6b4c\u79ae\u9084\u5728\u958b\u767c ASC30\uff0c\u8a72\u85e5\u5df2\u9032\u5165\u6cbb\u7642\u80a5\u80d6\u75c7\u7684I\u671f\u81e8\u5e8a\u8a66\u9a57\u3002 ASC30 \u662f\u4e00\u7a2e\u5c0f\u5206\u5b50 GLP-1R\uff0c\u53ef\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u6216\u6bcf\u6708\u76ae\u4e0b\u6ce8\u5c04\u4e00\u6b21\u3002ASC30\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7247(NCT06680440) \u548cASC30\u6bcf\u6708\u4e00\u6b21\u76ae\u4e0b\u6ce8\u5c04\u5291 (NCT06679959)\u7576\u524d\u5747\u5728\u7f8e\u570b\u958b\u5c55Ib\u671f\u7528\u65bc\u80a5\u80d6\u75c7\u6cbb\u7642\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u9802\u7dda\u6578\u64da\u9810\u8a08\u5c07\u65bc2025\u5e74\u7b2c\u4e00\u5b63\u5ea6\u516c\u4f48\u3002 \u95dc\u65bc\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8 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