{"id":283736,"date":"2024-12-13T22:09:00","date_gmt":"2024-12-13T14:09:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=283736"},"modified":"2024-12-13T22:09:00","modified_gmt":"2024-12-13T14:09:00","slug":"menarini-group-%e8%88%87-medsir-%e5%85%ac%e4%bd%88-adela-%e4%b8%89%e6%9c%9f%e7%a0%94%e7%a9%b6%ef%bc%9a%e6%99%9a%e6%9c%9f%e4%b9%b3%e7%99%8c%e6%96%b0%e6%b2%bb%e7%99%82%e7%ad%96%e7%95%a5","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=283736","title":{"rendered":"Menarini Group \u8207 MEDSIR \u516c\u4f48 ADELA \u4e09\u671f\u7814\u7a76\uff1a\u665a\u671f\u4e73\u764c\u65b0\u6cbb\u7642\u7b56\u7565"},"content":{"rendered":"<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul type=\"disc\">\n<li><i>ADELA \u662f\u4e00\u9805\u5728\u591a\u500b\u570b\u5bb6\u9032\u884c\u7684\u570b\u969b\u6027\u4e09\u671f\u7814\u7a76\uff0c\u7d50\u5408 elacestrant \u548c everolimus \u6291\u5236\u5291\u6cbb\u7642\u5e36\u6709 <\/i>ESR1<i> \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\uff0c\u65e8\u5728\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002<\/i><\/li>\n<li><i>\u662f\u6b21\u7814\u7a76\u7d50\u679c\u7531 Menarini Group \u548c MEDSIR \u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS 2024) \u4e0a\u767c\u8868\uff0cSABCS \u662f\u5168\u7403\u6700\u5177\u6b0a\u5a01\u7684\u816b\u7624\u5b78\u6703\u8b70\u4e4b\u4e00\u3002<\/i><\/li>\n<li><i>MEDSIR \u53c3\u8207 SABCS 2024 \u978f\u56fa\u4e86\u5176\u4f5c\u70ba\u5168\u7403\u816b\u7624\u5b78\u7814\u7a76\u9818\u5c0e\u8005\u7684\u5730\u4f4d\uff0c\u5f70\u986f\u4e86\u5176\u5c0d\u5275\u65b0\u53ca\u958b\u767c\u66f4\u500b\u4eba\u5316\u3001\u66f4\u6709\u6548\u7642\u6cd5\u7684\u627f\u8afe\u3002<\/i><\/li>\n<\/ul>\n<p><span class=\"legendSpanClass\">\u7fa9\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a3<\/span><span class=\"legendSpanClass\">2024\u5e7412\u670813\u65e5<\/span> \/\u7f8e\u901a\u793e\/ &#8212; \u570b\u969b\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group\uff08\u300cMenarini\u300d\uff09\u53ca\u5176\u5168\u8cc7\u5b50\u516c\u53f8 Stemline Therapeutics, Inc.\uff08\u300cStemline\u300d\uff09\uff08\u4e00\u5bb6\u81f4\u529b\u65bc\u70ba\u764c\u75c7\u60a3\u8005\u5e36\u4f86\u7a81\u7834\u6027\u816b\u7624\u6cbb\u7642\u7684\u5b50\u516c\u53f8\uff09\uff0c\u4ee5\u53ca\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u816b\u7624\u5c08\u79d1\u6cbb\u7642\u96c6\u5718 Oncocl\u00ednicas &amp; Co. \u65d7\u4e0b\u9818\u5148\u7684\u5168\u7403\u7368\u7acb\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u516c\u53f8 MEDSIR\uff0c\u5171\u540c\u767c\u4f48\u4e86\u95dc\u65bc\u958b\u5275\u6027\u81e8\u5e8a\u8a66\u9a57 ADELA \u7684\u7814\u7a76\u7d50\u679c\u3002\u9019\u9805\u91cd\u8981\u7814\u7a76\u89e3\u6c7a\u4e86\u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6cbb\u7642\u8010\u85e5\u6027\u554f\u984c\u3002\u8a72\u7814\u7a76\u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS) \u4e0a\u767c\u8868\uff0c\u4ee3\u8868\u8457\u70ba\u75c5\u60c5\u60e1\u5316\u7684\u60a3\u8005\u5c0b\u627e\u66f4\u6709\u6548\u548c\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6848\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/p>\n<p>\u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\u662f\u7d50\u5408\u5167\u5206\u6ccc\u6cbb\u7642\u548c CDK4\/6 \u6291\u5236\u5291\u3002<i>ESR1<\/i> \u7a81\u8b8a\u662f\u7531\u65bc\u5728\u8f49\u79fb\u6027\u6cbb\u7642\u671f\u9593\u524d\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u800c\u7522\u751f\u7684\uff0c\u9ad8\u9054 50% \u7684 ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u6703\u51fa\u73fe\u9019\u4e9b\u7a81\u8b8a\u3002<i>ESR1 <\/i>\u7a81\u8b8a\u6703\u5c0e\u81f4\u816b\u7624\u5c0d\u5167\u5206\u6ccc\u6cbb\u7642\u7522\u751f\u8010\u85e5\u6027\uff0c\u7e7c\u800c\u5c0e\u81f4\u764c\u75c7\u60e1\u5316\uff1b\u56e0\u6b64\uff0c\u6bcf\u7576\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60e1\u5316\u6642\uff0c\u90fd\u9700\u8981\u6aa2\u6e2c <i>ESR1<\/i>\u3002\u5728\u4e00\u7dda\u6cbb\u7642\u671f\u9593\uff0c\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u7684\u6642\u9593\u8d8a\u9577\uff0c\u60a3\u8005\u816b\u7624\u7522\u751f <i>ESR1<\/i> \u7a81\u8b8a\u7684\u6a5f\u6703\u5c31\u8d8a\u9ad8\u3002\u70ba\u4e86\u6eff\u8db3\u6b64\u91ab\u7642\u9700\u6c42\uff0cADELA \u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u4e86\u4e00\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u7d50\u5408\u65b0\u4e00\u4ee3\u53e3\u670d\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 elacestrant \u548c mTORC1 \u6291\u5236\u5291 everolimus\u3002<\/p>\n<p>\u76ee\u524d\u6b63\u5728\u8a55\u4f30\u6b64\u7d44\u5408\u7528\u65bc\u63a5\u53d7\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\uff0c\u4e26\u5e36\u6709 <i>ESR1<\/i> \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\u60a3\u8005\u3002Elacestrant \u7372\u6279\u7684\u4f9d\u64da\u662f EMERALD \u4e09\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u6b64\u5916\uff0ceverolimus \u5df2\u986f\u793a\u51fa\u6291\u5236\u6b64\u985e\u764c\u75c7\u5176\u4ed6\u8010\u85e5\u6a5f\u5236\u7684\u529f\u6548\u3002\u5728 <span class=\"xn-money\">1b<\/span>\/2 \u671f ELEVATE \u7814\u7a76 (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05563220\" target=\"_blank\" rel=\"nofollow noopener\">NCT05563220<\/a>) \u4e2d\uff0celacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\u5df2\u986f\u793a\u51fa\u521d\u6b65\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p>\u300c\u6211\u5011 Menarini Stemline \u5168\u9ad4\u6210\u54e1\u975e\u5e38\u69ae\u5e78\u5ba3\u4f48\u8207 MEDSIR \u5408\u4f5c\uff0c\u7e7c\u7e8c\u63a8\u9032\u81e8\u5e8a\u7814\u7a76\uff0c\u63a2\u7d22 elacestrant \u806f\u5408\u7642\u6cd5\uff0c\u300dStemline Therapeutics \u91ab\u7642\u7e3d\u76e3 Nassir Habboubi \u91ab\u5b78\u535a\u58eb\u8aaa\u9053\uff0c\u300c\u6211\u5011\u81f4\u529b\u65bc\u63d0\u4f9b\u7a81\u7834\u6027\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u5ef6\u9577\u764c\u75c7\u60a3\u8005\u7684\u751f\u547d\uff0c\u63a8\u52d5\u764c\u75c7\u6cbb\u7642\u7684\u5275\u65b0\u3002\u300d<\/p>\n<p>\u9019\u9805\u570b\u969b\u6027\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u6a19\u662f\u8a55\u4f30 elacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\uff0c\u76f8\u6bd4 elacestrant \u55ae\u4e00\u7642\u6cd5\uff0c\u662f\u5426\u80fd\u66f4\u6709\u6548\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4ea6\u63a2\u8a0e\u5176\u4ed6\u91cd\u8981\u65b9\u9762\uff0c\u4f8b\u5982\u7e3d\u9ad4\u5b58\u6d3b\u7387\u3001\u6bd2\u6027\u7279\u5fb5\uff0c\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u7684\u5f71\u97ff\u3002<\/p>\n<p>ADELA \u7814\u7a76\u662f\u4e86\u89e3\u5982\u4f55\u514b\u670d <i>ESR1<\/i> \u7a81\u8b8a\u60a3\u8005\u816b\u7624\u8010\u85e5\u6027\u6311\u6230\u7684\u95dc\u9375\u4e00\u6b65\uff0c\u76ee\u6a19\u662f\u9081\u5411\u66f4\u6709\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7642\u65b9\u6848\u3002<\/p>\n<p>\u300c\u5728 MEDSIR\uff0c\u6211\u5011\u8a8d\u70ba\u5275\u65b0\u4e0d\u50c5\u662f\u53d6\u5f97\u81e8\u5e8a\u6210\u679c\uff0c\u66f4\u91cd\u8981\u662f\u80fd\u5920\u5728\u5168\u7403\u7bc4\u570d\u5167\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u3002\u900f\u904e ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba <span class=\"xn-person\">Antonio Llombart-Cussac<\/span> \u535a\u58eb\u8aaa\u9053\u3002<\/p>\n<p>\u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002<\/p>\n<p>\u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002<\/p>\n<p><b>\u95dc\u65bc ORSERDU (elacestrant)<\/b><\/p>\n<p><b>U.S. Indication:<\/b>ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001<i>ESR1<\/i>&#8211; \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002<\/p>\n<p>\u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd <a href=\"http:\/\/www.orserdu.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.orserdu.com<\/a>\u3002<\/p>\n<p><b>\u91cd\u8981\u5b89\u5168\u8cc7\u8a0a<br \/><\/b><i>\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805<\/i><\/p>\n<p><i>\u9ad8\u8102\u8840\u75c7<\/i>\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002<\/p>\n<p><i>\u80da\u80ce-\u80ce\u5152\u6bd2\u6027<\/i>\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002<\/p>\n<p><i>\u4e0d\u826f\u53cd\u61c9<\/i><\/p>\n<p>\u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f<i>\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9<\/i>\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002<br \/><i>ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)<\/i>\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002<\/p>\n<p><i>\u85e5\u7269\u76f8\u4e92\u4f5c\u7528<\/i><\/p>\n<p><i>\u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528<\/i>\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002<\/p>\n<p><i>\u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805<\/i><\/p>\n<p><i>\u54fa\u4e73\u671f<\/i>\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002<br \/><i>\u809d\u529f\u80fd\u53d7\u640d<\/i>\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002<br \/>ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002<\/p>\n<p>\u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f <a href=\"http:\/\/www.fda.gov\/medwatch\" target=\"_blank\" rel=\"nofollow noopener\">www.fda.gov\/medwatch<\/a>\u3002<\/p>\n<p><b>\u95dc\u65bc The Menarini Group<\/b><\/p>\n<p>The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd <a href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.menarini.com&amp;esheet=53558844&amp;newsitemid=20230920907427&amp;lan=en-US&amp;anchor=www.menarini.com&amp;index=5&amp;md5=7682feaaefe280a649c9a9d8a9e54a2c\" target=\"_blank\" rel=\"nofollow noopener\">www.menarini.com<\/a>\u3002<\/p>\n<p><b>Stemline Therapeutics Inc. \u7c21\u4ecb<\/b><br \/>Stemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u548c\u5546\u696d\u5316\u7814\u7a76\u6210\u679c\u3002Stemline \u5c07\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316 ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624 (BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684 BPDCN \u6cbb\u7642\u65b9\u6848\u3002NEXPOVIO\u00ae (selinexor) \u662f\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5291\uff0cStemline \u4ea6\u5c07\u5176\u65bc\u6b50\u6d32\u5546\u696d\u5316 \u3002\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002<\/p>\n<p><b>\u95dc\u65bc MEDSIR<\/b><\/p>\n<p>MEDSIR \u6210\u7acb\u65bc 2012 \u5e74\uff0c\u4ee5\u8207\u5176\u7b56\u7565\u5925\u4f34\u7dca\u5bc6\u5408\u4f5c\uff0c\u63a8\u52d5\u816b\u7624\u5b78\u7814\u7a76\u5275\u65b0\u70ba\u69ae\u3002\u8a72\u516c\u53f8\u5728\u897f\u73ed\u7259\u548c\u7f8e\u570b\u958b\u5c55\u696d\u52d9\uff0c\u63d0\u4f9b\u6db5\u84cb\u7814\u7a76\u8a2d\u8a08\u5230\u51fa\u7248\u7684\u7aef\u5230\u7aef\u81e8\u5e8a\u8a66\u9a57\u7ba1\u7406\u670d\u52d9\uff0c\u4e26\u64c1\u6709\u5ee3\u6cdb\u7684\u5168\u7403\u5c08\u5bb6\u7db2\u7d61\u548c\u6574\u5408\u6280\u8853\uff0c\u6709\u6548\u7c21\u5316\u6d41\u7a0b\u3002MEDSIR \u63d0\u4f9b\u6982\u5ff5\u9a57\u8b49\u652f\u6301\u548c\u7b56\u7565\u65b9\u6cd5\uff0c\u4f7f\u7814\u7a76\u5408\u4f5c\u5925\u4f34\u80fd\u5920\u517c\u5f97\u5169\u8005\u7684\u512a\u52e2\uff1a\u884c\u696d\u81e8\u5e8a\u7814\u7a76\u548c\u7814\u7a76\u8005\u9a45\u52d5\u8a66\u9a57\u3002<\/p>\n<p>\u70ba\u4e86\u5728\u5168\u7403\u7bc4\u570d\u5167\u4fc3\u9032\u7368\u7acb\u7814\u7a76\uff0cMEDSIR \u8207\u5df4\u897f\u9818\u5148\u7684\u816b\u7624\u5b78\u96c6\u5718 Oncocl\u00ednicas \u5efa\u7acb\u4e86\u7b56\u7565\u806f\u76df\uff0cOncocl\u00ednicas \u5728\u5357\u7f8e\u6d32\u64c1\u6709\u5091\u51fa\u7684\u7814\u7a76\u6f5b\u529b\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff1awww.medsir.org\u202f<\/p>\n<p><b>\u95dc\u65bc Oncocl\u00ednicas &amp; CO<\/b><\/p>\n<p>Oncocl\u00ednicas&amp;Co \u662f\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u764c\u75c7\u6cbb\u7642\u96c6\u5718\uff0c\u63a1\u7528\u5c08\u6ce8\u65bc\u6574\u500b\u816b\u7624\u8b77\u7406\u65c5\u7a0b\u7684\u5c08\u696d\u5316\u548c\u5275\u65b0\u6a21\u5f0f\uff0c\u900f\u904e\u5176\u7531 2,700 \u591a\u540d\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\u7d44\u6210\u7684\u91ab\u7642\u5718\u968a\uff0c\u5c07\u9ad8\u6548\u7684\u71df\u904b\u3001\u4ee5\u4eba\u70ba\u672c\u7684\u8b77\u7406\u548c\u9ad8\u5ea6\u5c08\u696d\u5316\u7684\u670d\u52d9\u76f8\u7d50\u5408\u3002\u5176\u4f7f\u547d\u662f\u666e\u53ca\u764c\u75c7\u6cbb\u7642\uff0c\u63d0\u4f9b\u4e00\u500b\u6574\u5408\u9580\u8a3a\u8a3a\u6240\u548c\u9ad8\u5ea6\u8907\u96dc\u764c\u75c7\u4e2d\u5fc3\u7684\u7d9c\u5408\u7cfb\u7d71\u3002\u516c\u53f8\u5728\u5df4\u897f 39 \u500b\u57ce\u5e02\u71df\u904b 145 \u500b\u90e8\u9580\uff0c\u78ba\u4fdd\u5176\u670d\u52d9\u7bc4\u570d\u5167\u7684\u6240\u6709\u5730\u5340\u90fd\u80fd\u7372\u5f97\u7b26\u5408\u4e16\u754c\u4e00\u6d41\u6a19\u6e96\u7684\u9ad8\u8cea\u91cf\u670d\u52d9\u3002<\/p>\n<p>Oncocl\u00ednicas \u5c08\u6ce8\u65bc\u79d1\u6280\u3001\u7cbe\u6e96\u91ab\u7642\u548c\u57fa\u56e0\u7d44\u5b78\uff0c\u5728 2023 \u5e74\u9032\u884c\u4e86\u7d04 635,000 \u6b21\u6cbb\u7642\u3002\u516c\u53f8\u662f\u54c8\u4f5b\u91ab\u5b78\u9662\u9644\u5c6c <span class=\"xn-person\">Dana Farber<\/span> \u764c\u75c7\u7814\u7a76\u6240\uff08\u5168\u7403\u9818\u5148\u7684\u764c\u75c7\u7814\u7a76\u548c\u6cbb\u7642\u4e2d\u5fc3\u4e4b\u4e00\uff09\u5728\u5df4\u897f\u7684\u7368\u5bb6\u5408\u4f5c\u5925\u4f34\u3002\u6b64\u5916\uff0c\u516c\u53f8\u9084\u64c1\u6709\u4f4d\u65bc\u7f8e\u570b\u528d\u6a4b\u7684\u751f\u7269\u8cc7\u8a0a\u5b78\u516c\u53f8 Boston Lighthouse Innovation\uff0c\u4e26\u6301\u6709 Medsir \u7684\u80a1\u4efd\uff0cMedsir 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\u6307\u6578\u7684\u6210\u54e1\uff0c\u8a72\u6307\u6578\u91cd\u9ede\u95dc\u6ce8\u81f4\u529b\u65bc\u6027\u5225\u548c\u7a2e\u65cf\u591a\u5143\u5316\u7684\u516c\u53f8\u3002\u8a73\u60c5\u8acb\u700f\u89bd\uff1a<a href=\"https:\/\/www.grupooncoclinicas.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.grupooncoclinicas.com<\/a>\u3002<\/p>\n<p>\u00a0<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>ADELA \u662f\u4e00\u9805\u5728\u591a\u500b\u570b\u5bb6\u9032&#8230;<\/p>\n","protected":false},"author":16,"featured_media":283737,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[40567],"tags":[],"class_list":["post-283736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-40567"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Menarini Group \u8207 MEDSIR \u516c\u4f48 ADELA \u4e09\u671f\u7814\u7a76\uff1a\u665a\u671f\u4e73\u764c\u65b0\u6cbb\u7642\u7b56\u7565 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831<\/title>\n<meta name=\"description\" content=\"ADELA \u662f\u4e00\u9805\u5728\u591a\u500b\u570b\u5bb6\u9032\u884c\u7684\u570b\u969b\u6027\u4e09\u671f\u7814\u7a76\uff0c\u7d50\u5408 elacestrant \u548c everolimus \u6291\u5236\u5291\u6cbb\u7642\u5e36\u6709 ESR1 \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\uff0c\u65e8\u5728\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002  \u662f\u6b21\u7814\u7a76\u7d50\u679c\u7531 Menarini Group \u548c MEDSIR \u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS 2024) \u4e0a\u767c\u8868\uff0cSABCS \u662f\u5168\u7403\u6700\u5177\u6b0a\u5a01\u7684\u816b\u7624\u5b78\u6703\u8b70\u4e4b\u4e00\u3002  MEDSIR \u53c3\u8207 SABCS 2024 \u978f\u56fa\u4e86\u5176\u4f5c\u70ba\u5168\u7403\u816b\u7624\u5b78\u7814\u7a76\u9818\u5c0e\u8005\u7684\u5730\u4f4d\uff0c\u5f70\u986f\u4e86\u5176\u5c0d\u5275\u65b0\u53ca\u958b\u767c\u66f4\u500b\u4eba\u5316\u3001\u66f4\u6709\u6548\u7642\u6cd5\u7684\u627f\u8afe\u3002  \u7fa9\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a32024\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ -- \u570b\u969b\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group\uff08\u300cMenarini\u300d\uff09\u53ca\u5176\u5168\u8cc7\u5b50\u516c\u53f8 Stemline Therapeutics, Inc.\uff08\u300cStemline\u300d\uff09\uff08\u4e00\u5bb6\u81f4\u529b\u65bc\u70ba\u764c\u75c7\u60a3\u8005\u5e36\u4f86\u7a81\u7834\u6027\u816b\u7624\u6cbb\u7642\u7684\u5b50\u516c\u53f8\uff09\uff0c\u4ee5\u53ca\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u816b\u7624\u5c08\u79d1\u6cbb\u7642\u96c6\u5718 Oncocl\u00ednicas &amp; Co. \u65d7\u4e0b\u9818\u5148\u7684\u5168\u7403\u7368\u7acb\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u516c\u53f8 MEDSIR\uff0c\u5171\u540c\u767c\u4f48\u4e86\u95dc\u65bc\u958b\u5275\u6027\u81e8\u5e8a\u8a66\u9a57 ADELA \u7684\u7814\u7a76\u7d50\u679c\u3002\u9019\u9805\u91cd\u8981\u7814\u7a76\u89e3\u6c7a\u4e86\u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6cbb\u7642\u8010\u85e5\u6027\u554f\u984c\u3002\u8a72\u7814\u7a76\u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS) \u4e0a\u767c\u8868\uff0c\u4ee3\u8868\u8457\u70ba\u75c5\u60c5\u60e1\u5316\u7684\u60a3\u8005\u5c0b\u627e\u66f4\u6709\u6548\u548c\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6848\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\u662f\u7d50\u5408\u5167\u5206\u6ccc\u6cbb\u7642\u548c CDK4\/6 \u6291\u5236\u5291\u3002ESR1 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ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba Antonio Llombart-Cussac \u535a\u58eb\u8aaa\u9053\u3002 \u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002 \u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002 \u95dc\u65bc ORSERDU (elacestrant) U.S. Indication:ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001ESR1- \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002 \u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9 \u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528 \u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f www.fda.gov\/medwatch\u3002 \u95dc\u65bc The Menarini Group The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.menarini.com\u3002 Stemline Therapeutics Inc. \u7c21\u4ecbStemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u548c\u5546\u696d\u5316\u7814\u7a76\u6210\u679c\u3002Stemline \u5c07\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316 ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624 (BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684 BPDCN \u6cbb\u7642\u65b9\u6848\u3002NEXPOVIO\u00ae (selinexor) \u662f\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5291\uff0cStemline \u4ea6\u5c07\u5176\u65bc\u6b50\u6d32\u5546\u696d\u5316 \u3002\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002 \u95dc\u65bc MEDSIR MEDSIR \u6210\u7acb\u65bc 2012 \u5e74\uff0c\u4ee5\u8207\u5176\u7b56\u7565\u5925\u4f34\u7dca\u5bc6\u5408\u4f5c\uff0c\u63a8\u52d5\u816b\u7624\u5b78\u7814\u7a76\u5275\u65b0\u70ba\u69ae\u3002\u8a72\u516c\u53f8\u5728\u897f\u73ed\u7259\u548c\u7f8e\u570b\u958b\u5c55\u696d\u52d9\uff0c\u63d0\u4f9b\u6db5\u84cb\u7814\u7a76\u8a2d\u8a08\u5230\u51fa\u7248\u7684\u7aef\u5230\u7aef\u81e8\u5e8a\u8a66\u9a57\u7ba1\u7406\u670d\u52d9\uff0c\u4e26\u64c1\u6709\u5ee3\u6cdb\u7684\u5168\u7403\u5c08\u5bb6\u7db2\u7d61\u548c\u6574\u5408\u6280\u8853\uff0c\u6709\u6548\u7c21\u5316\u6d41\u7a0b\u3002MEDSIR \u63d0\u4f9b\u6982\u5ff5\u9a57\u8b49\u652f\u6301\u548c\u7b56\u7565\u65b9\u6cd5\uff0c\u4f7f\u7814\u7a76\u5408\u4f5c\u5925\u4f34\u80fd\u5920\u517c\u5f97\u5169\u8005\u7684\u512a\u52e2\uff1a\u884c\u696d\u81e8\u5e8a\u7814\u7a76\u548c\u7814\u7a76\u8005\u9a45\u52d5\u8a66\u9a57\u3002 \u70ba\u4e86\u5728\u5168\u7403\u7bc4\u570d\u5167\u4fc3\u9032\u7368\u7acb\u7814\u7a76\uff0cMEDSIR \u8207\u5df4\u897f\u9818\u5148\u7684\u816b\u7624\u5b78\u96c6\u5718 Oncocl\u00ednicas \u5efa\u7acb\u4e86\u7b56\u7565\u806f\u76df\uff0cOncocl\u00ednicas \u5728\u5357\u7f8e\u6d32\u64c1\u6709\u5091\u51fa\u7684\u7814\u7a76\u6f5b\u529b\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff1awww.medsir.org\u202f \u95dc\u65bc Oncocl\u00ednicas &amp; CO Oncocl\u00ednicas&amp;Co \u662f\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u764c\u75c7\u6cbb\u7642\u96c6\u5718\uff0c\u63a1\u7528\u5c08\u6ce8\u65bc\u6574\u500b\u816b\u7624\u8b77\u7406\u65c5\u7a0b\u7684\u5c08\u696d\u5316\u548c\u5275\u65b0\u6a21\u5f0f\uff0c\u900f\u904e\u5176\u7531 2,700 \u591a\u540d\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\u7d44\u6210\u7684\u91ab\u7642\u5718\u968a\uff0c\u5c07\u9ad8\u6548\u7684\u71df\u904b\u3001\u4ee5\u4eba\u70ba\u672c\u7684\u8b77\u7406\u548c\u9ad8\u5ea6\u5c08\u696d\u5316\u7684\u670d\u52d9\u76f8\u7d50\u5408\u3002\u5176\u4f7f\u547d\u662f\u666e\u53ca\u764c\u75c7\u6cbb\u7642\uff0c\u63d0\u4f9b\u4e00\u500b\u6574\u5408\u9580\u8a3a\u8a3a\u6240\u548c\u9ad8\u5ea6\u8907\u96dc\u764c\u75c7\u4e2d\u5fc3\u7684\u7d9c\u5408\u7cfb\u7d71\u3002\u516c\u53f8\u5728\u5df4\u897f 39 \u500b\u57ce\u5e02\u71df\u904b 145 \u500b\u90e8\u9580\uff0c\u78ba\u4fdd\u5176\u670d\u52d9\u7bc4\u570d\u5167\u7684\u6240\u6709\u5730\u5340\u90fd\u80fd\u7372\u5f97\u7b26\u5408\u4e16\u754c\u4e00\u6d41\u6a19\u6e96\u7684\u9ad8\u8cea\u91cf\u670d\u52d9\u3002 Oncocl\u00ednicas \u5c08\u6ce8\u65bc\u79d1\u6280\u3001\u7cbe\u6e96\u91ab\u7642\u548c\u57fa\u56e0\u7d44\u5b78\uff0c\u5728 2023 \u5e74\u9032\u884c\u4e86\u7d04 635,000 \u6b21\u6cbb\u7642\u3002\u516c\u53f8\u662f\u54c8\u4f5b\u91ab\u5b78\u9662\u9644\u5c6c Dana Farber \u764c\u75c7\u7814\u7a76\u6240\uff08\u5168\u7403\u9818\u5148\u7684\u764c\u75c7\u7814\u7a76\u548c\u6cbb\u7642\u4e2d\u5fc3\u4e4b\u4e00\uff09\u5728\u5df4\u897f\u7684\u7368\u5bb6\u5408\u4f5c\u5925\u4f34\u3002\u6b64\u5916\uff0c\u516c\u53f8\u9084\u64c1\u6709\u4f4d\u65bc\u7f8e\u570b\u528d\u6a4b\u7684\u751f\u7269\u8cc7\u8a0a\u5b78\u516c\u53f8 Boston Lighthouse Innovation\uff0c\u4e26\u6301\u6709 Medsir \u7684\u80a1\u4efd\uff0cMedsir \u662f\u4e00\u5bb6\u81f4\u529b\u65bc\u958b\u767c\u548c\u7ba1\u7406\u7368\u7acb\u764c\u75c7\u7814\u7a76\u81e8\u5e8a\u8a66\u9a57\u7684\u516c\u53f8\uff0c\u7e3d\u90e8\u4f4d\u65bc\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a3\u3002\u00a0 \u6700\u8fd1\uff0cOncocl\u00ednicas \u900f\u904e\u8207 Al Faisaliah Group \u6210\u7acb\u5408\u8cc7\u4f01\u696d\uff0c\u5c07\u696d\u52d9\u62d3\u5c55\u81f3\u6c99\u7279\u963f\u62c9\u4f2f\uff0c\u5c07\u5176\u6230\u52dd\u764c\u75c7\u7684\u4f7f\u547d\u5e36\u5230\u65b0\u7684\u5730\u57df\uff0c\u4e26\u900f\u904e\u7d50\u5408\u816b\u7624\u5b78\u8d85\u5c08\u696d\u5316\u8207\u5275\u65b0\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u5728\u5168\u7403\u7bc4\u570d\u5167\u63d0\u4f9b\u5148\u9032\u7684\u816b\u7624\u8b77\u7406\u3002 \u8a72\u516c\u53f8\u662f B3 \u63a8\u51fa\u7684 IDIVERSA \u6307\u6578\u7684\u6210\u54e1\uff0c\u8a72\u6307\u6578\u91cd\u9ede\u95dc\u6ce8\u81f4\u529b\u65bc\u6027\u5225\u548c\u7a2e\u65cf\u591a\u5143\u5316\u7684\u516c\u53f8\u3002\u8a73\u60c5\u8acb\u700f\u89bd\uff1awww.grupooncoclinicas.com\u3002 \u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=283736\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Menarini Group \u8207 MEDSIR \u516c\u4f48 ADELA \u4e09\u671f\u7814\u7a76\uff1a\u665a\u671f\u4e73\u764c\u65b0\u6cbb\u7642\u7b56\u7565 - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"ADELA \u662f\u4e00\u9805\u5728\u591a\u500b\u570b\u5bb6\u9032\u884c\u7684\u570b\u969b\u6027\u4e09\u671f\u7814\u7a76\uff0c\u7d50\u5408 elacestrant \u548c everolimus \u6291\u5236\u5291\u6cbb\u7642\u5e36\u6709 ESR1 \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\uff0c\u65e8\u5728\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002  \u662f\u6b21\u7814\u7a76\u7d50\u679c\u7531 Menarini Group \u548c MEDSIR \u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS 2024) \u4e0a\u767c\u8868\uff0cSABCS \u662f\u5168\u7403\u6700\u5177\u6b0a\u5a01\u7684\u816b\u7624\u5b78\u6703\u8b70\u4e4b\u4e00\u3002  MEDSIR \u53c3\u8207 SABCS 2024 \u978f\u56fa\u4e86\u5176\u4f5c\u70ba\u5168\u7403\u816b\u7624\u5b78\u7814\u7a76\u9818\u5c0e\u8005\u7684\u5730\u4f4d\uff0c\u5f70\u986f\u4e86\u5176\u5c0d\u5275\u65b0\u53ca\u958b\u767c\u66f4\u500b\u4eba\u5316\u3001\u66f4\u6709\u6548\u7642\u6cd5\u7684\u627f\u8afe\u3002  \u7fa9\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a32024\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ -- \u570b\u969b\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group\uff08\u300cMenarini\u300d\uff09\u53ca\u5176\u5168\u8cc7\u5b50\u516c\u53f8 Stemline Therapeutics, Inc.\uff08\u300cStemline\u300d\uff09\uff08\u4e00\u5bb6\u81f4\u529b\u65bc\u70ba\u764c\u75c7\u60a3\u8005\u5e36\u4f86\u7a81\u7834\u6027\u816b\u7624\u6cbb\u7642\u7684\u5b50\u516c\u53f8\uff09\uff0c\u4ee5\u53ca\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u816b\u7624\u5c08\u79d1\u6cbb\u7642\u96c6\u5718 Oncocl\u00ednicas &amp; Co. \u65d7\u4e0b\u9818\u5148\u7684\u5168\u7403\u7368\u7acb\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u516c\u53f8 MEDSIR\uff0c\u5171\u540c\u767c\u4f48\u4e86\u95dc\u65bc\u958b\u5275\u6027\u81e8\u5e8a\u8a66\u9a57 ADELA \u7684\u7814\u7a76\u7d50\u679c\u3002\u9019\u9805\u91cd\u8981\u7814\u7a76\u89e3\u6c7a\u4e86\u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6cbb\u7642\u8010\u85e5\u6027\u554f\u984c\u3002\u8a72\u7814\u7a76\u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS) \u4e0a\u767c\u8868\uff0c\u4ee3\u8868\u8457\u70ba\u75c5\u60c5\u60e1\u5316\u7684\u60a3\u8005\u5c0b\u627e\u66f4\u6709\u6548\u548c\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6848\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\u662f\u7d50\u5408\u5167\u5206\u6ccc\u6cbb\u7642\u548c CDK4\/6 \u6291\u5236\u5291\u3002ESR1 \u7a81\u8b8a\u662f\u7531\u65bc\u5728\u8f49\u79fb\u6027\u6cbb\u7642\u671f\u9593\u524d\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u800c\u7522\u751f\u7684\uff0c\u9ad8\u9054 50% \u7684 ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u6703\u51fa\u73fe\u9019\u4e9b\u7a81\u8b8a\u3002ESR1 \u7a81\u8b8a\u6703\u5c0e\u81f4\u816b\u7624\u5c0d\u5167\u5206\u6ccc\u6cbb\u7642\u7522\u751f\u8010\u85e5\u6027\uff0c\u7e7c\u800c\u5c0e\u81f4\u764c\u75c7\u60e1\u5316\uff1b\u56e0\u6b64\uff0c\u6bcf\u7576\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60e1\u5316\u6642\uff0c\u90fd\u9700\u8981\u6aa2\u6e2c ESR1\u3002\u5728\u4e00\u7dda\u6cbb\u7642\u671f\u9593\uff0c\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u7684\u6642\u9593\u8d8a\u9577\uff0c\u60a3\u8005\u816b\u7624\u7522\u751f ESR1 \u7a81\u8b8a\u7684\u6a5f\u6703\u5c31\u8d8a\u9ad8\u3002\u70ba\u4e86\u6eff\u8db3\u6b64\u91ab\u7642\u9700\u6c42\uff0cADELA \u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u4e86\u4e00\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u7d50\u5408\u65b0\u4e00\u4ee3\u53e3\u670d\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 elacestrant \u548c mTORC1 \u6291\u5236\u5291 everolimus\u3002 \u76ee\u524d\u6b63\u5728\u8a55\u4f30\u6b64\u7d44\u5408\u7528\u65bc\u63a5\u53d7\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\uff0c\u4e26\u5e36\u6709 ESR1 \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\u60a3\u8005\u3002Elacestrant \u7372\u6279\u7684\u4f9d\u64da\u662f EMERALD \u4e09\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u6b64\u5916\uff0ceverolimus \u5df2\u986f\u793a\u51fa\u6291\u5236\u6b64\u985e\u764c\u75c7\u5176\u4ed6\u8010\u85e5\u6a5f\u5236\u7684\u529f\u6548\u3002\u5728 1b\/2 \u671f ELEVATE \u7814\u7a76 (NCT05563220) \u4e2d\uff0celacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\u5df2\u986f\u793a\u51fa\u521d\u6b65\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002 \u300c\u6211\u5011 Menarini Stemline \u5168\u9ad4\u6210\u54e1\u975e\u5e38\u69ae\u5e78\u5ba3\u4f48\u8207 MEDSIR \u5408\u4f5c\uff0c\u7e7c\u7e8c\u63a8\u9032\u81e8\u5e8a\u7814\u7a76\uff0c\u63a2\u7d22 elacestrant \u806f\u5408\u7642\u6cd5\uff0c\u300dStemline Therapeutics \u91ab\u7642\u7e3d\u76e3 Nassir Habboubi \u91ab\u5b78\u535a\u58eb\u8aaa\u9053\uff0c\u300c\u6211\u5011\u81f4\u529b\u65bc\u63d0\u4f9b\u7a81\u7834\u6027\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u5ef6\u9577\u764c\u75c7\u60a3\u8005\u7684\u751f\u547d\uff0c\u63a8\u52d5\u764c\u75c7\u6cbb\u7642\u7684\u5275\u65b0\u3002\u300d \u9019\u9805\u570b\u969b\u6027\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u6a19\u662f\u8a55\u4f30 elacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\uff0c\u76f8\u6bd4 elacestrant \u55ae\u4e00\u7642\u6cd5\uff0c\u662f\u5426\u80fd\u66f4\u6709\u6548\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4ea6\u63a2\u8a0e\u5176\u4ed6\u91cd\u8981\u65b9\u9762\uff0c\u4f8b\u5982\u7e3d\u9ad4\u5b58\u6d3b\u7387\u3001\u6bd2\u6027\u7279\u5fb5\uff0c\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u7684\u5f71\u97ff\u3002 ADELA \u7814\u7a76\u662f\u4e86\u89e3\u5982\u4f55\u514b\u670d ESR1 \u7a81\u8b8a\u60a3\u8005\u816b\u7624\u8010\u85e5\u6027\u6311\u6230\u7684\u95dc\u9375\u4e00\u6b65\uff0c\u76ee\u6a19\u662f\u9081\u5411\u66f4\u6709\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u300c\u5728 MEDSIR\uff0c\u6211\u5011\u8a8d\u70ba\u5275\u65b0\u4e0d\u50c5\u662f\u53d6\u5f97\u81e8\u5e8a\u6210\u679c\uff0c\u66f4\u91cd\u8981\u662f\u80fd\u5920\u5728\u5168\u7403\u7bc4\u570d\u5167\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u3002\u900f\u904e ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba Antonio Llombart-Cussac \u535a\u58eb\u8aaa\u9053\u3002 \u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002 \u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002 \u95dc\u65bc ORSERDU (elacestrant) U.S. Indication:ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001ESR1- \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002 \u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9 \u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528 \u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f www.fda.gov\/medwatch\u3002 \u95dc\u65bc The Menarini Group The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.menarini.com\u3002 Stemline Therapeutics Inc. \u7c21\u4ecbStemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u548c\u5546\u696d\u5316\u7814\u7a76\u6210\u679c\u3002Stemline \u5c07\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316 ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624 (BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684 BPDCN \u6cbb\u7642\u65b9\u6848\u3002NEXPOVIO\u00ae (selinexor) \u662f\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5291\uff0cStemline \u4ea6\u5c07\u5176\u65bc\u6b50\u6d32\u5546\u696d\u5316 \u3002\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002 \u95dc\u65bc MEDSIR MEDSIR \u6210\u7acb\u65bc 2012 \u5e74\uff0c\u4ee5\u8207\u5176\u7b56\u7565\u5925\u4f34\u7dca\u5bc6\u5408\u4f5c\uff0c\u63a8\u52d5\u816b\u7624\u5b78\u7814\u7a76\u5275\u65b0\u70ba\u69ae\u3002\u8a72\u516c\u53f8\u5728\u897f\u73ed\u7259\u548c\u7f8e\u570b\u958b\u5c55\u696d\u52d9\uff0c\u63d0\u4f9b\u6db5\u84cb\u7814\u7a76\u8a2d\u8a08\u5230\u51fa\u7248\u7684\u7aef\u5230\u7aef\u81e8\u5e8a\u8a66\u9a57\u7ba1\u7406\u670d\u52d9\uff0c\u4e26\u64c1\u6709\u5ee3\u6cdb\u7684\u5168\u7403\u5c08\u5bb6\u7db2\u7d61\u548c\u6574\u5408\u6280\u8853\uff0c\u6709\u6548\u7c21\u5316\u6d41\u7a0b\u3002MEDSIR 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\u662f\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u764c\u75c7\u6cbb\u7642\u96c6\u5718\uff0c\u63a1\u7528\u5c08\u6ce8\u65bc\u6574\u500b\u816b\u7624\u8b77\u7406\u65c5\u7a0b\u7684\u5c08\u696d\u5316\u548c\u5275\u65b0\u6a21\u5f0f\uff0c\u900f\u904e\u5176\u7531 2,700 \u591a\u540d\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\u7d44\u6210\u7684\u91ab\u7642\u5718\u968a\uff0c\u5c07\u9ad8\u6548\u7684\u71df\u904b\u3001\u4ee5\u4eba\u70ba\u672c\u7684\u8b77\u7406\u548c\u9ad8\u5ea6\u5c08\u696d\u5316\u7684\u670d\u52d9\u76f8\u7d50\u5408\u3002\u5176\u4f7f\u547d\u662f\u666e\u53ca\u764c\u75c7\u6cbb\u7642\uff0c\u63d0\u4f9b\u4e00\u500b\u6574\u5408\u9580\u8a3a\u8a3a\u6240\u548c\u9ad8\u5ea6\u8907\u96dc\u764c\u75c7\u4e2d\u5fc3\u7684\u7d9c\u5408\u7cfb\u7d71\u3002\u516c\u53f8\u5728\u5df4\u897f 39 \u500b\u57ce\u5e02\u71df\u904b 145 \u500b\u90e8\u9580\uff0c\u78ba\u4fdd\u5176\u670d\u52d9\u7bc4\u570d\u5167\u7684\u6240\u6709\u5730\u5340\u90fd\u80fd\u7372\u5f97\u7b26\u5408\u4e16\u754c\u4e00\u6d41\u6a19\u6e96\u7684\u9ad8\u8cea\u91cf\u670d\u52d9\u3002 Oncocl\u00ednicas \u5c08\u6ce8\u65bc\u79d1\u6280\u3001\u7cbe\u6e96\u91ab\u7642\u548c\u57fa\u56e0\u7d44\u5b78\uff0c\u5728 2023 \u5e74\u9032\u884c\u4e86\u7d04 635,000 \u6b21\u6cbb\u7642\u3002\u516c\u53f8\u662f\u54c8\u4f5b\u91ab\u5b78\u9662\u9644\u5c6c Dana Farber \u764c\u75c7\u7814\u7a76\u6240\uff08\u5168\u7403\u9818\u5148\u7684\u764c\u75c7\u7814\u7a76\u548c\u6cbb\u7642\u4e2d\u5fc3\u4e4b\u4e00\uff09\u5728\u5df4\u897f\u7684\u7368\u5bb6\u5408\u4f5c\u5925\u4f34\u3002\u6b64\u5916\uff0c\u516c\u53f8\u9084\u64c1\u6709\u4f4d\u65bc\u7f8e\u570b\u528d\u6a4b\u7684\u751f\u7269\u8cc7\u8a0a\u5b78\u516c\u53f8 Boston Lighthouse Innovation\uff0c\u4e26\u6301\u6709 Medsir \u7684\u80a1\u4efd\uff0cMedsir \u662f\u4e00\u5bb6\u81f4\u529b\u65bc\u958b\u767c\u548c\u7ba1\u7406\u7368\u7acb\u764c\u75c7\u7814\u7a76\u81e8\u5e8a\u8a66\u9a57\u7684\u516c\u53f8\uff0c\u7e3d\u90e8\u4f4d\u65bc\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a3\u3002\u00a0 \u6700\u8fd1\uff0cOncocl\u00ednicas \u900f\u904e\u8207 Al Faisaliah Group \u6210\u7acb\u5408\u8cc7\u4f01\u696d\uff0c\u5c07\u696d\u52d9\u62d3\u5c55\u81f3\u6c99\u7279\u963f\u62c9\u4f2f\uff0c\u5c07\u5176\u6230\u52dd\u764c\u75c7\u7684\u4f7f\u547d\u5e36\u5230\u65b0\u7684\u5730\u57df\uff0c\u4e26\u900f\u904e\u7d50\u5408\u816b\u7624\u5b78\u8d85\u5c08\u696d\u5316\u8207\u5275\u65b0\u7684\u6cbb\u7642\u65b9\u6cd5\uff0c\u5728\u5168\u7403\u7bc4\u570d\u5167\u63d0\u4f9b\u5148\u9032\u7684\u816b\u7624\u8b77\u7406\u3002 \u8a72\u516c\u53f8\u662f B3 \u63a8\u51fa\u7684 IDIVERSA 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content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005:\" \/>\n\t<meta name=\"twitter:data1\" content=\"\u7f8e\u901a\u793e\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9810\u4f30\u95b1\u8b80\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 \u5206\u9418\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=283736#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/?p=283736\"},\"author\":{\"name\":\"\u7f8e\u901a\u793e\",\"@id\":\"https:\\\/\\\/pingtungtimes.com.tw\\\/#\\\/schema\\\/person\\\/683b937f29ec1537972f6c41e22a2cf3\"},\"headline\":\"Menarini Group \u8207 MEDSIR \u516c\u4f48 ADELA 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Inc.\uff08\u300cStemline\u300d\uff09\uff08\u4e00\u5bb6\u81f4\u529b\u65bc\u70ba\u764c\u75c7\u60a3\u8005\u5e36\u4f86\u7a81\u7834\u6027\u816b\u7624\u6cbb\u7642\u7684\u5b50\u516c\u53f8\uff09\uff0c\u4ee5\u53ca\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u816b\u7624\u5c08\u79d1\u6cbb\u7642\u96c6\u5718 Oncocl\u00ednicas &amp; Co. \u65d7\u4e0b\u9818\u5148\u7684\u5168\u7403\u7368\u7acb\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u516c\u53f8 MEDSIR\uff0c\u5171\u540c\u767c\u4f48\u4e86\u95dc\u65bc\u958b\u5275\u6027\u81e8\u5e8a\u8a66\u9a57 ADELA \u7684\u7814\u7a76\u7d50\u679c\u3002\u9019\u9805\u91cd\u8981\u7814\u7a76\u89e3\u6c7a\u4e86\u665a\u671f ER+\\\/HER2- \u4e73\u764c\u7684\u6cbb\u7642\u8010\u85e5\u6027\u554f\u984c\u3002\u8a72\u7814\u7a76\u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS) \u4e0a\u767c\u8868\uff0c\u4ee3\u8868\u8457\u70ba\u75c5\u60c5\u60e1\u5316\u7684\u60a3\u8005\u5c0b\u627e\u66f4\u6709\u6548\u548c\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6848\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \u665a\u671f ER+\\\/HER2- \u4e73\u764c\u7684\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\u662f\u7d50\u5408\u5167\u5206\u6ccc\u6cbb\u7642\u548c CDK4\\\/6 \u6291\u5236\u5291\u3002ESR1 \u7a81\u8b8a\u662f\u7531\u65bc\u5728\u8f49\u79fb\u6027\u6cbb\u7642\u671f\u9593\u524d\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u800c\u7522\u751f\u7684\uff0c\u9ad8\u9054 50% \u7684 ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u6703\u51fa\u73fe\u9019\u4e9b\u7a81\u8b8a\u3002ESR1 \u7a81\u8b8a\u6703\u5c0e\u81f4\u816b\u7624\u5c0d\u5167\u5206\u6ccc\u6cbb\u7642\u7522\u751f\u8010\u85e5\u6027\uff0c\u7e7c\u800c\u5c0e\u81f4\u764c\u75c7\u60e1\u5316\uff1b\u56e0\u6b64\uff0c\u6bcf\u7576\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60e1\u5316\u6642\uff0c\u90fd\u9700\u8981\u6aa2\u6e2c ESR1\u3002\u5728\u4e00\u7dda\u6cbb\u7642\u671f\u9593\uff0c\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u7684\u6642\u9593\u8d8a\u9577\uff0c\u60a3\u8005\u816b\u7624\u7522\u751f ESR1 \u7a81\u8b8a\u7684\u6a5f\u6703\u5c31\u8d8a\u9ad8\u3002\u70ba\u4e86\u6eff\u8db3\u6b64\u91ab\u7642\u9700\u6c42\uff0cADELA \u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u4e86\u4e00\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u7d50\u5408\u65b0\u4e00\u4ee3\u53e3\u670d\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 elacestrant \u548c mTORC1 \u6291\u5236\u5291 everolimus\u3002 \u76ee\u524d\u6b63\u5728\u8a55\u4f30\u6b64\u7d44\u5408\u7528\u65bc\u63a5\u53d7\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\uff0c\u4e26\u5e36\u6709 ESR1 \u7a81\u8b8a\u7684\u665a\u671f ER+\\\/HER2- \u4e73\u764c\u60a3\u8005\u3002Elacestrant \u7372\u6279\u7684\u4f9d\u64da\u662f EMERALD \u4e09\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u6b64\u5916\uff0ceverolimus \u5df2\u986f\u793a\u51fa\u6291\u5236\u6b64\u985e\u764c\u75c7\u5176\u4ed6\u8010\u85e5\u6a5f\u5236\u7684\u529f\u6548\u3002\u5728 1b\\\/2 \u671f ELEVATE \u7814\u7a76 (NCT05563220) \u4e2d\uff0celacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\u5df2\u986f\u793a\u51fa\u521d\u6b65\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002 \u300c\u6211\u5011 Menarini Stemline \u5168\u9ad4\u6210\u54e1\u975e\u5e38\u69ae\u5e78\u5ba3\u4f48\u8207 MEDSIR \u5408\u4f5c\uff0c\u7e7c\u7e8c\u63a8\u9032\u81e8\u5e8a\u7814\u7a76\uff0c\u63a2\u7d22 elacestrant \u806f\u5408\u7642\u6cd5\uff0c\u300dStemline Therapeutics \u91ab\u7642\u7e3d\u76e3 Nassir Habboubi \u91ab\u5b78\u535a\u58eb\u8aaa\u9053\uff0c\u300c\u6211\u5011\u81f4\u529b\u65bc\u63d0\u4f9b\u7a81\u7834\u6027\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u5ef6\u9577\u764c\u75c7\u60a3\u8005\u7684\u751f\u547d\uff0c\u63a8\u52d5\u764c\u75c7\u6cbb\u7642\u7684\u5275\u65b0\u3002\u300d \u9019\u9805\u570b\u969b\u6027\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u6a19\u662f\u8a55\u4f30 elacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\uff0c\u76f8\u6bd4 elacestrant \u55ae\u4e00\u7642\u6cd5\uff0c\u662f\u5426\u80fd\u66f4\u6709\u6548\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4ea6\u63a2\u8a0e\u5176\u4ed6\u91cd\u8981\u65b9\u9762\uff0c\u4f8b\u5982\u7e3d\u9ad4\u5b58\u6d3b\u7387\u3001\u6bd2\u6027\u7279\u5fb5\uff0c\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u7684\u5f71\u97ff\u3002 ADELA \u7814\u7a76\u662f\u4e86\u89e3\u5982\u4f55\u514b\u670d ESR1 \u7a81\u8b8a\u60a3\u8005\u816b\u7624\u8010\u85e5\u6027\u6311\u6230\u7684\u95dc\u9375\u4e00\u6b65\uff0c\u76ee\u6a19\u662f\u9081\u5411\u66f4\u6709\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u300c\u5728 MEDSIR\uff0c\u6211\u5011\u8a8d\u70ba\u5275\u65b0\u4e0d\u50c5\u662f\u53d6\u5f97\u81e8\u5e8a\u6210\u679c\uff0c\u66f4\u91cd\u8981\u662f\u80fd\u5920\u5728\u5168\u7403\u7bc4\u570d\u5167\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u3002\u900f\u904e ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba Antonio Llombart-Cussac \u535a\u58eb\u8aaa\u9053\u3002 \u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002 \u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002 \u95dc\u65bc ORSERDU (elacestrant) U.S. Indication:ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001ESR1- \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002 \u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9 \u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528 \u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\\\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f www.fda.gov\\\/medwatch\u3002 \u95dc\u65bc The Menarini Group The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\\\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.menarini.com\u3002 Stemline Therapeutics Inc. \u7c21\u4ecbStemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u548c\u5546\u696d\u5316\u7814\u7a76\u6210\u679c\u3002Stemline \u5c07\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316 ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624 (BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684 BPDCN \u6cbb\u7642\u65b9\u6848\u3002NEXPOVIO\u00ae (selinexor) \u662f\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5291\uff0cStemline \u4ea6\u5c07\u5176\u65bc\u6b50\u6d32\u5546\u696d\u5316 \u3002\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002 \u95dc\u65bc MEDSIR MEDSIR \u6210\u7acb\u65bc 2012 \u5e74\uff0c\u4ee5\u8207\u5176\u7b56\u7565\u5925\u4f34\u7dca\u5bc6\u5408\u4f5c\uff0c\u63a8\u52d5\u816b\u7624\u5b78\u7814\u7a76\u5275\u65b0\u70ba\u69ae\u3002\u8a72\u516c\u53f8\u5728\u897f\u73ed\u7259\u548c\u7f8e\u570b\u958b\u5c55\u696d\u52d9\uff0c\u63d0\u4f9b\u6db5\u84cb\u7814\u7a76\u8a2d\u8a08\u5230\u51fa\u7248\u7684\u7aef\u5230\u7aef\u81e8\u5e8a\u8a66\u9a57\u7ba1\u7406\u670d\u52d9\uff0c\u4e26\u64c1\u6709\u5ee3\u6cdb\u7684\u5168\u7403\u5c08\u5bb6\u7db2\u7d61\u548c\u6574\u5408\u6280\u8853\uff0c\u6709\u6548\u7c21\u5316\u6d41\u7a0b\u3002MEDSIR 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\u662f\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u764c\u75c7\u6cbb\u7642\u96c6\u5718\uff0c\u63a1\u7528\u5c08\u6ce8\u65bc\u6574\u500b\u816b\u7624\u8b77\u7406\u65c5\u7a0b\u7684\u5c08\u696d\u5316\u548c\u5275\u65b0\u6a21\u5f0f\uff0c\u900f\u904e\u5176\u7531 2,700 \u591a\u540d\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\u7d44\u6210\u7684\u91ab\u7642\u5718\u968a\uff0c\u5c07\u9ad8\u6548\u7684\u71df\u904b\u3001\u4ee5\u4eba\u70ba\u672c\u7684\u8b77\u7406\u548c\u9ad8\u5ea6\u5c08\u696d\u5316\u7684\u670d\u52d9\u76f8\u7d50\u5408\u3002\u5176\u4f7f\u547d\u662f\u666e\u53ca\u764c\u75c7\u6cbb\u7642\uff0c\u63d0\u4f9b\u4e00\u500b\u6574\u5408\u9580\u8a3a\u8a3a\u6240\u548c\u9ad8\u5ea6\u8907\u96dc\u764c\u75c7\u4e2d\u5fc3\u7684\u7d9c\u5408\u7cfb\u7d71\u3002\u516c\u53f8\u5728\u5df4\u897f 39 \u500b\u57ce\u5e02\u71df\u904b 145 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\u55ae\u4e00\u7642\u6cd5\uff0c\u662f\u5426\u80fd\u66f4\u6709\u6548\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4ea6\u63a2\u8a0e\u5176\u4ed6\u91cd\u8981\u65b9\u9762\uff0c\u4f8b\u5982\u7e3d\u9ad4\u5b58\u6d3b\u7387\u3001\u6bd2\u6027\u7279\u5fb5\uff0c\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u7684\u5f71\u97ff\u3002 ADELA \u7814\u7a76\u662f\u4e86\u89e3\u5982\u4f55\u514b\u670d ESR1 \u7a81\u8b8a\u60a3\u8005\u816b\u7624\u8010\u85e5\u6027\u6311\u6230\u7684\u95dc\u9375\u4e00\u6b65\uff0c\u76ee\u6a19\u662f\u9081\u5411\u66f4\u6709\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u300c\u5728 MEDSIR\uff0c\u6211\u5011\u8a8d\u70ba\u5275\u65b0\u4e0d\u50c5\u662f\u53d6\u5f97\u81e8\u5e8a\u6210\u679c\uff0c\u66f4\u91cd\u8981\u662f\u80fd\u5920\u5728\u5168\u7403\u7bc4\u570d\u5167\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u3002\u900f\u904e ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba Antonio Llombart-Cussac \u535a\u58eb\u8aaa\u9053\u3002 \u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002 \u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002 \u95dc\u65bc ORSERDU (elacestrant) U.S. Indication:ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001ESR1- \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002 \u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9 \u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528 \u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f www.fda.gov\/medwatch\u3002 \u95dc\u65bc The Menarini Group The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.menarini.com\u3002 Stemline Therapeutics Inc. \u7c21\u4ecbStemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u548c\u5546\u696d\u5316\u7814\u7a76\u6210\u679c\u3002Stemline \u5c07\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316 ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624 (BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684 BPDCN \u6cbb\u7642\u65b9\u6848\u3002NEXPOVIO\u00ae (selinexor) \u662f\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5291\uff0cStemline \u4ea6\u5c07\u5176\u65bc\u6b50\u6d32\u5546\u696d\u5316 \u3002\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002 \u95dc\u65bc MEDSIR MEDSIR \u6210\u7acb\u65bc 2012 \u5e74\uff0c\u4ee5\u8207\u5176\u7b56\u7565\u5925\u4f34\u7dca\u5bc6\u5408\u4f5c\uff0c\u63a8\u52d5\u816b\u7624\u5b78\u7814\u7a76\u5275\u65b0\u70ba\u69ae\u3002\u8a72\u516c\u53f8\u5728\u897f\u73ed\u7259\u548c\u7f8e\u570b\u958b\u5c55\u696d\u52d9\uff0c\u63d0\u4f9b\u6db5\u84cb\u7814\u7a76\u8a2d\u8a08\u5230\u51fa\u7248\u7684\u7aef\u5230\u7aef\u81e8\u5e8a\u8a66\u9a57\u7ba1\u7406\u670d\u52d9\uff0c\u4e26\u64c1\u6709\u5ee3\u6cdb\u7684\u5168\u7403\u5c08\u5bb6\u7db2\u7d61\u548c\u6574\u5408\u6280\u8853\uff0c\u6709\u6548\u7c21\u5316\u6d41\u7a0b\u3002MEDSIR \u63d0\u4f9b\u6982\u5ff5\u9a57\u8b49\u652f\u6301\u548c\u7b56\u7565\u65b9\u6cd5\uff0c\u4f7f\u7814\u7a76\u5408\u4f5c\u5925\u4f34\u80fd\u5920\u517c\u5f97\u5169\u8005\u7684\u512a\u52e2\uff1a\u884c\u696d\u81e8\u5e8a\u7814\u7a76\u548c\u7814\u7a76\u8005\u9a45\u52d5\u8a66\u9a57\u3002 \u70ba\u4e86\u5728\u5168\u7403\u7bc4\u570d\u5167\u4fc3\u9032\u7368\u7acb\u7814\u7a76\uff0cMEDSIR \u8207\u5df4\u897f\u9818\u5148\u7684\u816b\u7624\u5b78\u96c6\u5718 Oncocl\u00ednicas \u5efa\u7acb\u4e86\u7b56\u7565\u806f\u76df\uff0cOncocl\u00ednicas \u5728\u5357\u7f8e\u6d32\u64c1\u6709\u5091\u51fa\u7684\u7814\u7a76\u6f5b\u529b\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff1awww.medsir.org\u202f \u95dc\u65bc Oncocl\u00ednicas &amp; CO Oncocl\u00ednicas&amp;Co \u662f\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u764c\u75c7\u6cbb\u7642\u96c6\u5718\uff0c\u63a1\u7528\u5c08\u6ce8\u65bc\u6574\u500b\u816b\u7624\u8b77\u7406\u65c5\u7a0b\u7684\u5c08\u696d\u5316\u548c\u5275\u65b0\u6a21\u5f0f\uff0c\u900f\u904e\u5176\u7531 2,700 \u591a\u540d\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\u7d44\u6210\u7684\u91ab\u7642\u5718\u968a\uff0c\u5c07\u9ad8\u6548\u7684\u71df\u904b\u3001\u4ee5\u4eba\u70ba\u672c\u7684\u8b77\u7406\u548c\u9ad8\u5ea6\u5c08\u696d\u5316\u7684\u670d\u52d9\u76f8\u7d50\u5408\u3002\u5176\u4f7f\u547d\u662f\u666e\u53ca\u764c\u75c7\u6cbb\u7642\uff0c\u63d0\u4f9b\u4e00\u500b\u6574\u5408\u9580\u8a3a\u8a3a\u6240\u548c\u9ad8\u5ea6\u8907\u96dc\u764c\u75c7\u4e2d\u5fc3\u7684\u7d9c\u5408\u7cfb\u7d71\u3002\u516c\u53f8\u5728\u5df4\u897f 39 \u500b\u57ce\u5e02\u71df\u904b 145 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\u4e73\u764c\uff0c\u65e8\u5728\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002  \u662f\u6b21\u7814\u7a76\u7d50\u679c\u7531 Menarini Group \u548c MEDSIR \u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS 2024) \u4e0a\u767c\u8868\uff0cSABCS \u662f\u5168\u7403\u6700\u5177\u6b0a\u5a01\u7684\u816b\u7624\u5b78\u6703\u8b70\u4e4b\u4e00\u3002  MEDSIR \u53c3\u8207 SABCS 2024 \u978f\u56fa\u4e86\u5176\u4f5c\u70ba\u5168\u7403\u816b\u7624\u5b78\u7814\u7a76\u9818\u5c0e\u8005\u7684\u5730\u4f4d\uff0c\u5f70\u986f\u4e86\u5176\u5c0d\u5275\u65b0\u53ca\u958b\u767c\u66f4\u500b\u4eba\u5316\u3001\u66f4\u6709\u6548\u7642\u6cd5\u7684\u627f\u8afe\u3002  \u7fa9\u5927\u5229\u4f5b\u7f85\u502b\u65af\u548c\u897f\u73ed\u7259\u5df4\u585e\u7f85\u90a32024\u5e7412\u670813\u65e5 \/\u7f8e\u901a\u793e\/ -- \u570b\u969b\u9818\u5148\u7684\u88fd\u85e5\u548c\u8a3a\u65b7\u516c\u53f8 Menarini Group\uff08\u300cMenarini\u300d\uff09\u53ca\u5176\u5168\u8cc7\u5b50\u516c\u53f8 Stemline Therapeutics, Inc.\uff08\u300cStemline\u300d\uff09\uff08\u4e00\u5bb6\u81f4\u529b\u65bc\u70ba\u764c\u75c7\u60a3\u8005\u5e36\u4f86\u7a81\u7834\u6027\u816b\u7624\u6cbb\u7642\u7684\u5b50\u516c\u53f8\uff09\uff0c\u4ee5\u53ca\u62c9\u4e01\u7f8e\u6d32\u6700\u5927\u7684\u816b\u7624\u5c08\u79d1\u6cbb\u7642\u96c6\u5718 Oncocl\u00ednicas &amp; Co. \u65d7\u4e0b\u9818\u5148\u7684\u5168\u7403\u7368\u7acb\u816b\u7624\u81e8\u5e8a\u7814\u7a76\u516c\u53f8 MEDSIR\uff0c\u5171\u540c\u767c\u4f48\u4e86\u95dc\u65bc\u958b\u5275\u6027\u81e8\u5e8a\u8a66\u9a57 ADELA \u7684\u7814\u7a76\u7d50\u679c\u3002\u9019\u9805\u91cd\u8981\u7814\u7a76\u89e3\u6c7a\u4e86\u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6cbb\u7642\u8010\u85e5\u6027\u554f\u984c\u3002\u8a72\u7814\u7a76\u5728 2024 \u5e74\u8056\u5b89\u6771\u5c3c\u5967\u4e73\u764c\u7814\u8a0e\u6703 (SABCS) \u4e0a\u767c\u8868\uff0c\u4ee3\u8868\u8457\u70ba\u75c5\u60c5\u60e1\u5316\u7684\u60a3\u8005\u5c0b\u627e\u66f4\u6709\u6548\u548c\u500b\u4eba\u5316\u6cbb\u7642\u65b9\u6848\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \u665a\u671f ER+\/HER2- \u4e73\u764c\u7684\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u65b9\u6cd5\u662f\u7d50\u5408\u5167\u5206\u6ccc\u6cbb\u7642\u548c CDK4\/6 \u6291\u5236\u5291\u3002ESR1 \u7a81\u8b8a\u662f\u7531\u65bc\u5728\u8f49\u79fb\u6027\u6cbb\u7642\u671f\u9593\u524d\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u800c\u7522\u751f\u7684\uff0c\u9ad8\u9054 50% \u7684 ER+\u3001HER2- \u665a\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u60a3\u8005\u6703\u51fa\u73fe\u9019\u4e9b\u7a81\u8b8a\u3002ESR1 \u7a81\u8b8a\u6703\u5c0e\u81f4\u816b\u7624\u5c0d\u5167\u5206\u6ccc\u6cbb\u7642\u7522\u751f\u8010\u85e5\u6027\uff0c\u7e7c\u800c\u5c0e\u81f4\u764c\u75c7\u60e1\u5316\uff1b\u56e0\u6b64\uff0c\u6bcf\u7576\u8f49\u79fb\u6027\u4e73\u764c (mBC) \u60e1\u5316\u6642\uff0c\u90fd\u9700\u8981\u6aa2\u6e2c ESR1\u3002\u5728\u4e00\u7dda\u6cbb\u7642\u671f\u9593\uff0c\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u7684\u6642\u9593\u8d8a\u9577\uff0c\u60a3\u8005\u816b\u7624\u7522\u751f ESR1 \u7a81\u8b8a\u7684\u6a5f\u6703\u5c31\u8d8a\u9ad8\u3002\u70ba\u4e86\u6eff\u8db3\u6b64\u91ab\u7642\u9700\u6c42\uff0cADELA \u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u4e86\u4e00\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u7d50\u5408\u65b0\u4e00\u4ee3\u53e3\u670d\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 elacestrant \u548c mTORC1 \u6291\u5236\u5291 everolimus\u3002 \u76ee\u524d\u6b63\u5728\u8a55\u4f30\u6b64\u7d44\u5408\u7528\u65bc\u63a5\u53d7\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\uff0c\u4e26\u5e36\u6709 ESR1 \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\u60a3\u8005\u3002Elacestrant \u7372\u6279\u7684\u4f9d\u64da\u662f EMERALD \u4e09\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u6b64\u5916\uff0ceverolimus 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\u9019\u9805\u570b\u969b\u6027\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u6a19\u662f\u8a55\u4f30 elacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\uff0c\u76f8\u6bd4 elacestrant \u55ae\u4e00\u7642\u6cd5\uff0c\u662f\u5426\u80fd\u66f4\u6709\u6548\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4ea6\u63a2\u8a0e\u5176\u4ed6\u91cd\u8981\u65b9\u9762\uff0c\u4f8b\u5982\u7e3d\u9ad4\u5b58\u6d3b\u7387\u3001\u6bd2\u6027\u7279\u5fb5\uff0c\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u7684\u5f71\u97ff\u3002 ADELA \u7814\u7a76\u662f\u4e86\u89e3\u5982\u4f55\u514b\u670d ESR1 \u7a81\u8b8a\u60a3\u8005\u816b\u7624\u8010\u85e5\u6027\u6311\u6230\u7684\u95dc\u9375\u4e00\u6b65\uff0c\u76ee\u6a19\u662f\u9081\u5411\u66f4\u6709\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u300c\u5728 MEDSIR\uff0c\u6211\u5011\u8a8d\u70ba\u5275\u65b0\u4e0d\u50c5\u662f\u53d6\u5f97\u81e8\u5e8a\u6210\u679c\uff0c\u66f4\u91cd\u8981\u662f\u80fd\u5920\u5728\u5168\u7403\u7bc4\u570d\u5167\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u3002\u900f\u904e ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba Antonio Llombart-Cussac \u535a\u58eb\u8aaa\u9053\u3002 \u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002 \u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002 \u95dc\u65bc ORSERDU (elacestrant) U.S. Indication:ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001ESR1- \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002 \u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9 \u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528 \u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f www.fda.gov\/medwatch\u3002 \u95dc\u65bc The Menarini Group The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.menarini.com\u3002 Stemline Therapeutics Inc. \u7c21\u4ecbStemline Therapeutics, Inc. (\u300cStemline\u300d) \u662f Menarini Group \u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u7814\u767c\u65b0\u578b\u816b\u7624\u5b78\u6cbb\u7642\u85e5\u7269\u7684\u548c\u5546\u696d\u5316\u7814\u7a76\u6210\u679c\u3002Stemline \u5c07\u65bc\u7f8e\u570b\u548c\u6b50\u6d32\u5546\u696d\u5316 ORSERDU\u00ae (elacestrant) \uff0c\u9019\u662f\u4e00\u7a2e\u53e3\u670d\u5167\u5206\u6ccc\u6cbb\u7642\u85e5\u7269\uff0c\u9069\u7528\u65bc\u60a3\u6709\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER) \u967d\u6027\u3001\u4eba\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u9670\u6027\u3001ESR1 \u7a81\u8b8a\u7684\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\uff0c\u4e14\u5728\u63a5\u53d7\u81f3\u5c11\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\u7684\u7d55\u7d93\u5f8c\u5973\u6027\u6216\u6210\u5e74\u7537\u6027\u3002Stemline \u9084\u5728\u7f8e\u570b\u548c\u6b50\u6d32\u63a8\u51fa ELZONRIS\u00ae (tagraxofusp-erzs) \uff0c\u9019\u662f\u4e00\u7a2e\u91dd\u5c0d CD123 \u7684\u5275\u65b0\u6a19\u9776\u6cbb\u7642\uff0c\u7528\u65bc\u6cbb\u7642\u7206\u767c\u6027\u6f3f\u7d30\u80de\u6a39\u7a81\u7d30\u80de\u816b\u7624 (BPDCN)\uff08\u4e00\u7a2e\u4fb5\u8972\u6027\u8840\u6db2\u764c\u75c7\uff09\u60a3\u8005\uff0c\u4e5f\u662f\u7f8e\u570b\u548c\u6b50\u76df\u8fc4\u4eca\u552f\u4e00\u7372\u6279\u7684 BPDCN \u6cbb\u7642\u65b9\u6848\u3002NEXPOVIO\u00ae (selinexor) \u662f\u4e00\u7a2e\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684 XPO1 \u6291\u5236\u5291\uff0cStemline \u4ea6\u5c07\u5176\u65bc\u6b50\u6d32\u5546\u696d\u5316 \u3002\u6b64\u5916\uff0cStemline \u9084\u64c1\u6709\u5ee3\u6cdb\u7684\u5c0f\u5206\u5b50\u548c\u751f\u7269\u88fd\u5291\u81e8\u5e8a\u7522\u54c1\u7ba1\u9053\uff0c\u9019\u4e9b\u7522\u54c1\u8655\u65bc\u4e0d\u540c\u7684\u958b\u767c\u968e\u6bb5\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u591a\u7a2e\u5be6\u9ad4\u764c\u548c\u8840\u764c\u3002 \u95dc\u65bc MEDSIR MEDSIR \u6210\u7acb\u65bc 2012 \u5e74\uff0c\u4ee5\u8207\u5176\u7b56\u7565\u5925\u4f34\u7dca\u5bc6\u5408\u4f5c\uff0c\u63a8\u52d5\u816b\u7624\u5b78\u7814\u7a76\u5275\u65b0\u70ba\u69ae\u3002\u8a72\u516c\u53f8\u5728\u897f\u73ed\u7259\u548c\u7f8e\u570b\u958b\u5c55\u696d\u52d9\uff0c\u63d0\u4f9b\u6db5\u84cb\u7814\u7a76\u8a2d\u8a08\u5230\u51fa\u7248\u7684\u7aef\u5230\u7aef\u81e8\u5e8a\u8a66\u9a57\u7ba1\u7406\u670d\u52d9\uff0c\u4e26\u64c1\u6709\u5ee3\u6cdb\u7684\u5168\u7403\u5c08\u5bb6\u7db2\u7d61\u548c\u6574\u5408\u6280\u8853\uff0c\u6709\u6548\u7c21\u5316\u6d41\u7a0b\u3002MEDSIR \u63d0\u4f9b\u6982\u5ff5\u9a57\u8b49\u652f\u6301\u548c\u7b56\u7565\u65b9\u6cd5\uff0c\u4f7f\u7814\u7a76\u5408\u4f5c\u5925\u4f34\u80fd\u5920\u517c\u5f97\u5169\u8005\u7684\u512a\u52e2\uff1a\u884c\u696d\u81e8\u5e8a\u7814\u7a76\u548c\u7814\u7a76\u8005\u9a45\u52d5\u8a66\u9a57\u3002 \u70ba\u4e86\u5728\u5168\u7403\u7bc4\u570d\u5167\u4fc3\u9032\u7368\u7acb\u7814\u7a76\uff0cMEDSIR \u8207\u5df4\u897f\u9818\u5148\u7684\u816b\u7624\u5b78\u96c6\u5718 Oncocl\u00ednicas \u5efa\u7acb\u4e86\u7b56\u7565\u806f\u76df\uff0cOncocl\u00ednicas \u5728\u5357\u7f8e\u6d32\u64c1\u6709\u5091\u51fa\u7684\u7814\u7a76\u6f5b\u529b\u3002\u5982\u6b32\u4e86\u89e3\u66f4\u591a\u8cc7\u8a0a\uff1awww.medsir.org\u202f \u95dc\u65bc Oncocl\u00ednicas &amp; CO Oncocl\u00ednicas&amp;Co 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ESR1\u3002\u5728\u4e00\u7dda\u6cbb\u7642\u671f\u9593\uff0c\u63a5\u53d7\u5167\u5206\u6ccc\u6cbb\u7642\u7684\u6642\u9593\u8d8a\u9577\uff0c\u60a3\u8005\u816b\u7624\u7522\u751f ESR1 \u7a81\u8b8a\u7684\u6a5f\u6703\u5c31\u8d8a\u9ad8\u3002\u70ba\u4e86\u6eff\u8db3\u6b64\u91ab\u7642\u9700\u6c42\uff0cADELA \u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\u7814\u7a76\u4e86\u4e00\u7a2e\u65b0\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u7d50\u5408\u65b0\u4e00\u4ee3\u53e3\u670d\u9078\u64c7\u6027\u96cc\u6fc0\u7d20\u53d7\u9ad4\u964d\u89e3\u5291 elacestrant \u548c mTORC1 \u6291\u5236\u5291 everolimus\u3002 \u76ee\u524d\u6b63\u5728\u8a55\u4f30\u6b64\u7d44\u5408\u7528\u65bc\u63a5\u53d7\u6a19\u6e96\u4e00\u7dda\u6cbb\u7642\u5f8c\u75c5\u60c5\u60e1\u5316\uff0c\u4e26\u5e36\u6709 ESR1 \u7a81\u8b8a\u7684\u665a\u671f ER+\/HER2- \u4e73\u764c\u60a3\u8005\u3002Elacestrant \u7372\u6279\u7684\u4f9d\u64da\u662f EMERALD \u4e09\u671f\u7814\u7a76\u7684\u7d50\u679c\u3002\u6b64\u5916\uff0ceverolimus \u5df2\u986f\u793a\u51fa\u6291\u5236\u6b64\u985e\u764c\u75c7\u5176\u4ed6\u8010\u85e5\u6a5f\u5236\u7684\u529f\u6548\u3002\u5728 1b\/2 \u671f ELEVATE \u7814\u7a76 (NCT05563220) \u4e2d\uff0celacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\u5df2\u986f\u793a\u51fa\u521d\u6b65\u7642\u6548\u548c\u53ef\u63a7\u7684\u5b89\u5168\u6027\u3002 \u300c\u6211\u5011 Menarini Stemline \u5168\u9ad4\u6210\u54e1\u975e\u5e38\u69ae\u5e78\u5ba3\u4f48\u8207 MEDSIR \u5408\u4f5c\uff0c\u7e7c\u7e8c\u63a8\u9032\u81e8\u5e8a\u7814\u7a76\uff0c\u63a2\u7d22 elacestrant \u806f\u5408\u7642\u6cd5\uff0c\u300dStemline Therapeutics \u91ab\u7642\u7e3d\u76e3 Nassir Habboubi \u91ab\u5b78\u535a\u58eb\u8aaa\u9053\uff0c\u300c\u6211\u5011\u81f4\u529b\u65bc\u63d0\u4f9b\u7a81\u7834\u6027\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u4ee5\u5ef6\u9577\u764c\u75c7\u60a3\u8005\u7684\u751f\u547d\uff0c\u63a8\u52d5\u764c\u75c7\u6cbb\u7642\u7684\u5275\u65b0\u3002\u300d \u9019\u9805\u570b\u969b\u6027\u3001\u96a8\u6a5f\u3001\u96d9\u76f2\u8a66\u9a57\u7684\u4e3b\u8981\u76ee\u6a19\u662f\u8a55\u4f30 elacestrant \u548c everolimus \u7d44\u5408\u7642\u6cd5\uff0c\u76f8\u6bd4 elacestrant \u55ae\u4e00\u7642\u6cd5\uff0c\u662f\u5426\u80fd\u66f4\u6709\u6548\u5ef6\u7de9\u75c5\u60c5\u60e1\u5316\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4ea6\u63a2\u8a0e\u5176\u4ed6\u91cd\u8981\u65b9\u9762\uff0c\u4f8b\u5982\u7e3d\u9ad4\u5b58\u6d3b\u7387\u3001\u6bd2\u6027\u7279\u5fb5\uff0c\u4ee5\u53ca\u5c0d\u60a3\u8005\u751f\u6d3b\u8cea\u91cf\u7684\u5f71\u97ff\u3002 ADELA \u7814\u7a76\u662f\u4e86\u89e3\u5982\u4f55\u514b\u670d ESR1 \u7a81\u8b8a\u60a3\u8005\u816b\u7624\u8010\u85e5\u6027\u6311\u6230\u7684\u95dc\u9375\u4e00\u6b65\uff0c\u76ee\u6a19\u662f\u9081\u5411\u66f4\u6709\u6548\u3001\u66f4\u5b89\u5168\u7684\u6cbb\u7642\u65b9\u6848\u3002 \u300c\u5728 MEDSIR\uff0c\u6211\u5011\u8a8d\u70ba\u5275\u65b0\u4e0d\u50c5\u662f\u53d6\u5f97\u81e8\u5e8a\u6210\u679c\uff0c\u66f4\u91cd\u8981\u662f\u80fd\u5920\u5728\u5168\u7403\u7bc4\u570d\u5167\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u3002\u900f\u904e ADELA\uff0c\u6211\u5011\u671d\u8457\u5be6\u73fe\u66f4\u4f4e\u4fb5\u5165\u6027\u53ca\u66f4\u6613\u65bc\u7372\u5f97\u7684\u6cbb\u7642\u65b9\u6cd5\u9081\u51fa\u4e86\u95dc\u9375\u4e00\u6b65\uff0c\u70ba\u9762\u5c0d\u8907\u96dc\u75c5\u60c5\u7684\u60a3\u8005\u5e36\u4f86\u65b0\u5e0c\u671b\u3002\u9019\u9032\u4e00\u6b65\u5f37\u5316\u4e86\u6211\u5011\u5c0d\u500b\u4eba\u5316\u548c\u4ee5\u75c5\u4eba\u70ba\u4e2d\u5fc3\u7684\u91ab\u7642\u670d\u52d9\u7684\u627f\u8afe\uff0c\u9019\u4ea6\u662f\u5851\u9020\u816b\u7624\u5b78\u672a\u4f86\u7684\u57fa\u77f3\u3002\u300dMEDSIR \u9ad8\u7d1a\u79d1\u5b78\u8ca0\u8cac\u4eba Antonio Llombart-Cussac \u535a\u58eb\u8aaa\u9053\u3002 \u9019\u9805\u4e09\u671f\u7814\u7a76\u4e0d\u4f46\u5177\u6709\u91cd\u8981\u7684\u81e8\u5e8a\u76ee\u6a19\uff0c\u66f4\u6709\u6f5b\u529b\u70ba\u6b64\u6cbb\u7642\u7d44\u5408\u53d6\u5f97\u76e3\u7ba1\u6279\u51c6\u92ea\u8def\uff0c\u8b93\u66f4\u591a\u665a\u671f\u4e73\u764c\u60a3\u8005\u53d7\u60e0\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u9019\u9805\u7814\u7a76\u7684\u570b\u969b\u7bc4\u570d\u6db5\u84cb\u591a\u500b\u570b\u5bb6\uff0c\u5305\u62ec\u897f\u73ed\u7259\u3001\u7fa9\u5927\u5229\u3001\u6cd5\u570b\u3001\u5967\u5730\u5229\u3001\u6377\u514b\u5171\u548c\u570b\u3001\u5e0c\u81d8\u3001\u5fb7\u570b\u548c\u82f1\u570b\uff0c\u7a81\u986f\u4e86\u8a72\u7814\u7a76\u5728\u5168\u7403\u79d1\u5b78\u754c\u7684\u91cd\u5927\u610f\u7fa9\u548c\u5f71\u97ff\u529b\u3002 \u5728 SABCS 2024 \u5982\u6b64\u91cd\u8981\u7684\u6703\u8b70\u4e0a\u767c\u8868 ADELA \u7814\u7a76\uff0c\u5f37\u5316\u4e86 MEDSIR \u5728\u8ffd\u6c42\u5353\u8d8a\u7684\u816b\u7624\u5b78\u7814\u7a76\u9818\u57df\u7684\u9818\u5c0e\u5730\u4f4d\uff0c\u4e26\u7a81\u986f\u4e86\u5176\u81f4\u529b\u65bc\u89e3\u6c7a\u4e73\u764c\u6cbb\u7642\u4e2d\u672a\u6eff\u8db3\u9700\u6c42\u7684\u76ee\u6a19\u3002ADELA \u7814\u7a76\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u4e26\u5df2\u958b\u59cb\u62db\u52df\u60a3\u8005\u3002 \u95dc\u65bc ORSERDU (elacestrant) U.S. Indication:ORSERDU (elacestrant)\uff0c345 \u6beb\u514b\u7247\u5291\uff0c\u9069\u7528\u65bc\u6cbb\u7642\u96cc\u6fc0\u7d20\u53d7\u9ad4 (ER)\u70ba\u967d\u6027\u3001\u4eba\u985e\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4 2 (HER2) \u70ba\u9670\u6027\u3001ESR1- \u81f3\u5c11\u66fe\u4f7f\u7528\u904e\u4e00\u7dda\u5167\u5206\u6ccc\u6cbb\u7642\u5f8c\u3001\u75be\u75c5\u60e1\u5316\u7684\u7a81\u8b8a\u672b\u671f\u6216\u8f49\u79fb\u6027\u4e73\u764c\u75c5\u4eba\u3002 \u6b32\u77ad\u89e3\u7f8e\u570b\u7684\u5b8c\u6574\u8655\u65b9\u8cc7\u8a0a\uff0c\u53ef\u4ee5\u700f\u89bd www.orserdu.com\u3002 \u91cd\u8981\u5b89\u5168\u8cc7\u8a0a\u8b66\u544a\u548c\u6ce8\u610f\u4e8b\u9805 \u9ad8\u8102\u8840\u75c7\uff1a\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c30% \u51fa\u73fe\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\uff0c27% \u51fa\u73fe\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u30023 \u7d1a\u548c 4 \u7d1a\u9ad8\u81bd\u56fa\u9187\u8840\u75c7\u548c\u9ad8\u4e09\u9178\u7518\u6cb9\u8102\u8840\u75c7\u7684\u767c\u751f\u7387\u5206\u5225\u70ba 0.9% \u548c 2.2%\u3002\u5728\u958b\u59cb ORSERDU \u6cbb\u7642\u524d\u4ee5\u53ca\u6cbb\u7642\u671f\u9593\u9808\u5b9a\u671f\u76e3\u6e2c\u8840\u8102\u60c5\u6cc1\u3002 \u80da\u80ce-\u80ce\u5152\u6bd2\u6027\uff1a\u6839\u64da\u52d5\u7269\u7814\u7a76\u7684\u767c\u73fe\u53ca\u5176\u4f5c\u7528\u6a5f\u5236\uff0c\u70ba\u5b55\u5a66\u8655\u65b9 ORSERDU \u53ef\u80fd\u6703\u5c0d\u8179\u4e2d\u7684\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u3002\u8acb\u5411\u5b55\u5a66\u548c\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u544a\u77e5\u53ef\u80fd\u5c0d\u80ce\u5152\u9020\u6210\u50b7\u5bb3\u7684\u98a8\u96aa\u3002\u5efa\u8b70\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u670d\u7528\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002\u5c0d\u65bc\u7537\u6027\u60a3\u8005\u7684\u3001\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u4f34\u4fb6\uff0c\u5efa\u8b70\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\uff0c\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3002 \u4e0d\u826f\u53cd\u61c9 \u6709 12% \u7684\u670d\u7528 ORSERDU \u60a3\u8005\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u3002\u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u4e2d\uff0c\u767c\u751f\u56b4\u91cd\u4e0d\u826f\u53cd\u61c9\u7684\u60a3\u8005\u6bd4\u4f8b\u8d85\u904e 1%\uff0c\u9019\u4e9b\u53cd\u61c9\u5305\u62ec\u808c\u8089\u9aa8\u9abc\u75bc\u75db (1.7%) \u548c\u5641\u5fc3 (1.3%) \u30021.7% \u63a5\u53d7 ORSERDU \u6cbb\u7642\u7684\u60a3\u8005\u51fa\u73fe\u81f4\u547d\u7684\u4e0d\u826f\u53cd\u61c9\uff0c\u5305\u62ec\u5fc3\u81df\u9a5f\u505c\u3001\u6557\u8840\u6027\u4f11\u514b\u3001\u61a9\u5ba4\u708e\u548c\u539f\u56e0\u4e0d\u660e\u7684\u60c5\u6cc1\uff08\u5404\u4e00\u4f8b\uff09\u3002ORSERDU \u6700\u5e38\u898b\u7684\u4e0d\u826f\u53cd\u61c9 (\u2265 10\uff05)\uff0c\u5305\u62ec\u5be6\u9a57\u5ba4\u7570\u5e38\uff0cORSERDU \u6709\u808c\u8089\u9aa8\u9abc\u75bc\u75db (41%)\u3001\u5641\u5fc3 (35%)\u3001\u81bd\u56fa\u9187\u589e\u52a0 (30%)\u3001AST \u589e\u52a0 (29%)\u3001\u4e09\u9178\u7518\u6cb9\u8102\u589e\u52a0 (27%)\u3001\u75b2\u52de (26%)\u3001\u8840\u7d05\u86cb\u767d\u6e1b\u5c11 (26%)\u3001\u5614\u5410 (19%)\u3001ALT \u589e\u9ad8 (17%)\u3001\u9209\u964d\u4f4e (16%)\u3001\u808c\u9178\u9150\u589e\u9ad8 (16%)\u3001\u98df\u617e\u964d\u4f4e (15%)\u3001\u8179\u7009 (13%)\u3001\u982d\u75db (12%)\u3001\u4fbf\u79d8 (12%)\u3001\u8179\u75db (11%)\u3001\u6f6e\u71b1 (11%) \u53ca\u6d88\u5316\u4e0d\u826f (10%)\u3002 \u85e5\u7269\u76f8\u4e92\u4f5c\u7528 \u8207 CYP3A4 \u8a98\u5c0e\u5291\u548c\/\u6216\u6291\u88fd\u5291\u540c\u6642\u4f7f\u7528\uff1a\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u6291\u5236\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002\u907f\u514d\u8207\u5f37\u6548\u6216\u4e2d\u5ea6 CYP3A4 \u8a98\u5c0e\u5291\u548c ORSERDU \u4e00\u8d77\u4f7f\u7528\u3002 \u4f7f\u7528\u65bc\u7279\u5b9a\u7fa4\u7d44\u7684\u6ce8\u610f\u4e8b\u9805 \u54fa\u4e73\u671f\uff1a\u5efa\u8b70\u54fa\u4e73\u671f\u5a66\u5973\u5728\u63a5\u53d7 ORSERDU \u6cbb\u7642\u671f\u9593\u76f4\u5230\u6700\u5f8c\u4e00\u5291\u5f8c\u7684 1 \u9031\u5167\u4e0d\u8981\u54fa\u4e73\u3002\u809d\u529f\u80fd\u53d7\u640d\uff1a\u907f\u514d\u7d66\u56b4\u91cd\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh C) \u7684\u60a3\u8005\u4f7f\u7528 ORSERDU\u3002\u4e2d\u5ea6\u809d\u529f\u80fd\u53d7\u640d (Child-Pugh B) \u7684\u60a3\u8005\u8981\u6e1b\u5c11 ORSERDU \u7684\u5291\u91cf\u3002ORSERDU \u5728\u5152\u79d1\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u5c1a\u672a\u78ba\u5b9a\u3002 \u5982\u8981\u5831\u544a\u61f7\u7591\u4e0d\u826f\u53cd\u61c9\uff0c\u8acb\u81f4\u96fb 1-877-332-7961 \u806f\u7d61 Stemline Therapeutics, Inc.\uff0c\u6216\u81f4\u96fb 1-800-FDA-1088 \u806f\u7d61\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \uff0c\u6216\u8a2a\u554f www.fda.gov\/medwatch\u3002 \u95dc\u65bc The Menarini Group The Menarini Group\u662f\u4e00\u5bb6\u9818\u5148\u7684\u570b\u969b\u91ab\u85e5\u548c\u8a3a\u65b7\u516c\u53f8\uff0c\u5e74\u71df\u696d\u984d\u8d85\u904e47\u5104\u7f8e\u5143\uff0c\u64c1\u6709\u8d85\u904e17000\u540d\u54e1\u5de5\u3002Menarini \u5c08\u6ce8\u65bc\u7814\u767c\u6cbb\u7642\u9700\u6c42\u672a\u88ab\u6eff\u8db3\u7684\u9818\u57df\uff0c\u5176\u7522\u54c1\u6db5\u84cb\u5fc3\u81df\u75c5\u5b78\u3001\u816b\u7624\u5b78\u3001\u547c\u5438\u75c5\u5b78\u3001\u80c3\u8178\u75c5\u5b78\u3001\u50b3\u67d3\u75c5\u5b78\u3001\u7cd6\u5c3f\u75c5\u5b78\u3001\u708e\u75c7\u548c\u93ae\u75db\u7b49\u9818\u57df\u3002Menarini \u64c1\u6709 18 \u500b\u751f\u7522\u57fa\u5730\u548c 9 \u500b\u7814\u767c\u4e2d\u5fc3\uff0c\u7522\u54c1\u92b7\u5f80\u5168\u7403 140 \u500b\u570b\u5bb6\/\u5730\u5340\u3002\u6b32\u4e86\u89e3\u66f4\u591a\u76f8\u95dc\u8cc7\u8a0a\uff0c\u8acb\u700f\u89bd www.menarini.com\u3002 Stemline Therapeutics Inc. \u7c21\u4ecbStemline Therapeutics, Inc. 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