{"id":282955,"date":"2024-12-10T22:29:00","date_gmt":"2024-12-10T14:29:00","guid":{"rendered":"https:\/\/pingtungtimes.com.tw\/?p=282955"},"modified":"2024-12-10T22:29:00","modified_gmt":"2024-12-10T14:29:00","slug":"%e3%80%90%e7%9b%b4%e6%93%8aash-2024%e3%80%91%e4%b8%ad%e4%bd%8dpfs%e8%b6%859%e5%80%8b%e6%9c%88%ef%bc%81%e4%ba%9e%e7%9b%9b%e9%86%ab%e8%97%a5bcl-2%e6%8a%91%e5%88%b6%e5%8a%91apg-2575%e5%8f%a3%e9%a0%ad","status":"publish","type":"post","link":"https:\/\/pingtungtimes.com.tw\/?p=282955","title":{"rendered":"\u3010\u76f4\u64caASH 2024\u3011\u4e2d\u4f4dPFS\u8d859\u500b\u6708\uff01\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u53e3\u982d\u5831\u544a\u5c55\u793a\u6cbb\u7642R\/R MM\u60a3\u8005\u512a\u79c0\u6578\u64da"},"content":{"rendered":"
\n\n\n\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span>2024\u5e7412\u670810\u65e5<\/span> \/\u7f8e\u901a\u793e\/ — \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u53e3\u982d\u5831\u544a\u4e86\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291APG-2575\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u3002\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u7684Sikander Ailawadhi\u6559\u6388\u548cAsher A. Chanan-Khan\u6559\u6388\u70ba\u8a72\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\u3002<\/p>\n

\n<\/p><\/div>\n

ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u00ae<\/sup>\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002<\/p>\n

\u6b64\u6b21\u53e3\u982d\u5831\u544a\u4e2d\u6240\u5c55\u793a\u7684\u95dc\u65bcAPG-2575\u6cbb\u7642R\/R MM\u7684\u7814\u7a76\u7d50\u679c\uff0c\u9032\u4e00\u6b65\u9ad4\u73fe\u51fa\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u7684\u5f37\u52c1\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\u3002\u6578\u64da\u986f\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u768436\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7e3d\u53cd\u61c9\u7387\uff08ORR\uff09\u905463.9%\uff0c\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\u7387\u905430.6%\uff0c\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9ad8\u90549.7\u6708\uff1b\u800c\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cAPG-2575\u5728800-1200mg\u5291\u91cf\u4e0b\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\u6642\u4ecd\u5448\u73fe\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e14\u5747\u672a\u767c\u751f\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u3002\u9019\u662f\u7b2c\u4e00\u500bBcl-2\u6291\u5236\u5291\u5728\u9ad8\u5291\u91cf\u4e0b\u9577\u6642\u9593\u4f7f\u7528\u7684\u7814\u7a76\u5831\u544a\u3002<\/p>\n

Sikander Ailawadhi<\/span><\/b>\u6559\u6388<\/b>\u8868\u793a\uff1a\u300c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u7684R\/R MM\u60a3\u8005\u4e2d\uff0cAPG-2575\u806f\u5408Pd\u65b9\u6848\u986f\u793a\u4e86\u66f4\u9ad8\u7684\u7de9\u89e3\u7387\u548c\u66f4\u9577\u7684\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff0c\u5176\u4e2d\u4e5f\u5305\u62ec\u6297CD38\u6297\u9ad4\u85e5\u7269\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u7814\u7a76\u4e2d\uff0c\u57fa\u65bcAPG-2575\u7684\u7642\u6cd5\u986f\u793a\u4e86\u5f88\u597d\u7684\u5b89\u5168\u6027\uff0c\u5373\u4f7f\u7814\u7a76\u63a1\u7528\u4e86\u8f03\u9ad8\u7684\u5291\u91cf\u3002\u9019\u610f\u5473\u8457\u8a72\u85e5\u7269\u6709\u671b\u70baR\/R MM\u60a3\u8005\u5e36\u4f86\u4e00\u6b3e\u6709\u6548\u7684\u9776\u5411\u7642\u6cd5\u3002\u300d<\/p>\n

\u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208APG-2575\u91dd\u5c0dR\/R MM\u7684\u7814\u7a76\u6210\u679c\u80fd\u7372\u5165\u9078\u53e3\u982d\u5831\u544a\uff0c\u5728ASH\u5e74\u6703\u4e0a\u518d\u6b21\u9a57\u8b49\u4e86\u9019\u4e00\u5168\u7403’Best-in-class’\u6f5b\u529b\u54c1\u7a2e\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002MM\u6cbb\u7642\u9818\u57df\u8fd1\u5e74\u4f86\u96d6\u7136\u6709\u5f88\u591a\u9032\u5c55\uff0c\u4f46\u662f\u5fa9\u767c\u96e3\u6cbb,\u7279\u5225\u662f\u7d93\u904e\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u3001\u514d\u75ab\u8abf\u7bc0\u5291CD38\u55ae\u6297\u5747\u6cbb\u7642\u5931\u6557\u7684MM\uff0c\u4ecd\u7136\u662f\u5f37\u70c8\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-2575\u5728\u591a\u7a2e\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u7624\u6cbb\u7642\u9818\u57df\u5177\u5099\u5ee3\u95ca\u7684\u6cbb\u7642\u524d\u666f\uff0c\u5176\u91dd\u5c0dR\/R\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u53d7\u7406\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5805\u5b88’\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42’\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d<\/p>\n

\u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a<\/p>\n

Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (pts) with Relapsed or Refractory Multiple Myeloma (R\/R MM) or Immunoglobulin Light-Chain (AL) Amyloidosis<\/b><\/p>\n

Lisaftoclax<\/b>\uff08<\/b>APG-2575<\/b>\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c<\/b>\/<\/b>\u96e3\u6cbb\u6027\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08<\/b>R\/R MM<\/b>\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08<\/b>AL<\/b>\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\uff08<\/b>pts<\/b>\uff09<\/b><\/p>\n

\u5c55\u793a\u5f62\u5f0f\uff1a<\/b>\u53e3\u982d\u5831\u544a
\u6458\u8981\u7de8\u865f\uff1a<\/b>1022
\u5206\u6703\u5834\uff1a<\/b>654. \u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff1a\u85e5\u7269\u7642\u6cd5\uff1a\u672a\u4f86\u5c55\u671b\uff1a\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u65b0\u85e5\u548c\u806f\u5408\u7642\u6cd5<\/p>\n

\u6838\u5fc3\u8981\u9ede\uff1a<\/b><\/p>\n

\u7814\u7a76\u80cc\u666f<\/u>\uff1a<\/p>\n

    \n
  • MM\u7684\u7279\u5fb5\u662f\u7570\u5e38\u6f3f\u7d30\u80de\u514b\u9686\u589e\u6b96\uff0c\u5c0e\u81f4\u7834\u58de\u6027\u9aa8\u75c5\u8b8a\u3001\u814e\u640d\u50b7\u3001\u8ca7\u8840\u548c\u9ad8\u9223\u8840\u75c7\u3002MM\u7684\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u514d\u75ab\u8abf\u7bc0\u5291\u3001\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u548c\u6297CD38\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u4ee5\u9054\u5230\u75be\u75c5\u7de9\u89e3\u7684\u76ee\u7684\u3002<\/li>\n
  • AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7d30\u80de\u5916\u932f\u8aa4\u6298\u758a\u86cb\u767d\u7570\u5e38\u6c89\u7a4d\u65bc\u5404\u5668\u5b98\u4e26\u9020\u6210\u640d\u5bb3\u7684\u75be\u75c5\uff0c\u4e3b\u8981\u6cbb\u7642\u7b56\u7565\u662f\u63a8\u9072\u5668\u5b98\u529f\u80fd\u969c\u7919\u7684\u6642\u9593\u6216\u9006\u8f49\u5668\u5b98\u529f\u80fd\u969c\u7919\u3002\u7136\u800c\uff0c\u8a31\u591a\u60a3\u8005\u5728\u63a5\u53d7\u6a19\u6e96\u7684\u4e09\u806f\u6216\u56db\u806f\u7642\u6cd5\u5f8c\u6703\u51fa\u73fe\u5fa9\u767c\uff0c\u9019\u5c31\u9700\u8981\u63a1\u7528\u5177\u6709\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u5176\u4ed6\u7642\u6cd5\u3002<\/li>\n
  • APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u65b0\u578bBcl-2\u6291\u5236\u5291\uff0c\u5728\u524d\u671f\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u5f88\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u6b64\uff0c\u6211\u5011\u5831\u544a\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u5728R\/R MM\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u3002<\/li>\n<\/ul>\n

    \u7814\u7a76\u4ecb\u7d39<\/u>\uff1a\u9019\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u3002<\/p>\n

    \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5<\/u>\uff1a<\/p>\n

      \n
    • \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u9700 ECOG\u8a55\u5206 \u2264 2\uff0c\u65e2\u5f80\u63a5\u53d7\u904e\u2265 1\u7a2e\u6cbb\u7642\uff0c\u4e14\u5668\u5b98\u529f\u80fd\u6b63\u5e38\u3002R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u5df2\u78ba\u8a3a\u6709\u75c7\u72c0\u7684\u5668\u5b98\u53d7\u7d2f\u3002APG-2575\uff08Lisaftoclax\uff09\u6bcf\u65e5\u53e3\u670d\uff0c\u4ee528\u5929\u70ba\u9031\u671f\u91cd\u8907\u7d66\u85e5\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u548c\u4f86\u90a3\u5ea6\u80fa\u6309\u8aaa\u660e\u66f8\u7528\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e 40 mg\uff0820 mg\uff0c\u5e74\u9f61>75\u6b72\uff09\u572828\u5929\u9031\u671f\u7684\u7b2c1\u30018\u300115\u548c22\u5929\u7d66\u85e5\u3002<\/li>\n
    • \u9019\u9805\u7814\u7a76\u8a55\u4f30\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u6cbb\u7642R\/R MM\u60a3\u8005\uff08Pd\uff1b\u6cbb\u7642\u7d44A\uff09\uff1b\u806f\u5408\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u6cbb\u7642R\/R MM\u60a3\u8005\uff08DRd\uff1b\u6cbb\u7642\u7d44B\uff09\uff1b\u806f\u5408Pd\u65b9\u6848\u6cbb\u7642R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08\u6cbb\u7642\u7d44C\uff09\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/li>\n
    • \u622a\u81f32024\u5e7411\u67085\u65e5\uff0c\u5171\u670958\u4f8b\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d\u5305\u62ec48\u4f8bR\/R MM\u60a3\u8005\u548c10\u4f8bAL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u3002<\/li>\n
    • \u5728A\u7d44\uff08n=41\uff09\u4e2d\uff0cAPG-2575\uff08Lisaftoclax\uff09\u6309\u6307\u5b9a\u5291\u91cf\u53e3\u670d\u7d66\u85e5\uff1a400mg\uff083\u4f8b\uff09\u3001600mg\uff084\u4f8b\uff09\u3001800mg\uff0815\u4f8b\uff09\u30011,000mg\uff0813\u4f8b\uff09\u548c1,200mg\uff086\u4f8b\uff09\u3002\u5728B\u7d44\uff08n=7\uff09\u4e2d\uff0c\u6240\u6709\u60a3\u8005\u90fd\u63a5\u53d7\u4e86600mg APG-2575\uff08Lisaftoclax\uff09\u7684\u6cbb\u7642\u3002\u5728 C \u7d44\uff08n=10\uff09\u4e2d\uff0c\u7d66\u85e5\u5291\u91cf\u5206\u5225\u70ba400 mg\uff081\u4f8b\uff09\u3001600 mg\uff084\u4f8b\uff09\u3001800 mg\uff083\u4f8b\uff09\u548c 1,000 mg\uff082\u4f8b\uff09\u3002<\/li>\n<\/ul>\n

      \u7642\u6548\u6578\u64da<\/u>\uff1a<\/p>\n

        \n
      • A \u7d4436\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u67093\u4f8b\uff088.3%\uff09\u9054\u5230\u4e86\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\uff0c8\u4f8b\uff0822.2%\uff09\u9054\u5230VGPR\uff0c12\u4f8b\uff0833.3%\uff09\u9054\u5230\u90e8\u5206\u7de9\u89e3 (PR)\u3002ORR\u70ba63.9%\uff0823\u4f8b\uff09\uff0c11\u4f8b\uff0830.6%\uff09\u9054\u5230\u2265 VGPR\u3002<\/li>\n
      • B\u7d445\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u67092\u4f8b\uff0840%\uff09\u9054\u5230CR\u3002<\/li>\n
      • C\u7d449\u4f8b\u63a5\u53d7\u8a55\u4f30\u7684\u60a3\u8005\u4e2d\uff0c1\u4f8b\uff0811.1%\uff09\u9054\u5230CR\uff0c6\u4f8b\uff0866.7%\uff09\u9054\u5230 VGPR\uff0cORR \u70ba 88.9%\uff088\u4f8b\uff09\uff1b2\u4f8b\u7372\u5f97\u5fc3\u81df\u53cd\u61c9\u3002<\/li>\n<\/ul>\n

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        \u7d50\u8ad6<\/u>\uff1a\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0cAPG-2575\uff08Lisaftoclax\uff09\u806f\u5408Pd\u6216DRd\u65b9\u6848\u53ef\u63d0\u9ad8R\/R MM\u6216AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u7de9\u89e3\u6df1\u5ea6\u3002\u9019\u4e9b\u806f\u5408\u7642\u6cd5\u986f\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u5c24\u5176\u662f\u8840\u6db2\u5b78\u4e0d\u826f\u53cd\u61c9\u65b9\u9762\uff0c\u4e14\u7121\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

        \u95dc\u65bc\u4e9e\u76db\u91ab\u85e5<\/u><\/b><\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u662f\u4e00\u5bb6\u7d9c\u5408\u6027\u7684\u5168\u7403\u751f\u7269\u91ab\u85e5\u4f01\u696d\uff0c\u81f4\u529b\u65bc\u7814\u767c\u5275\u65b0\u85e5\uff0c\u4ee5\u89e3\u6c7a\u816b\u7624\u7b49\u9818\u57df\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u30022019\u5e7410\u670828\u65e5\uff0c\u516c\u53f8\u5728\u9999\u6e2f\u806f\u4ea4\u6240\u4e3b\u677f\u639b\u724c\u4e0a\u5e02\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a6855.HK\u3002<\/p>\n

        \u4e9e\u76db\u91ab\u85e5\u5df2\u5efa\u7acb\u8c50\u5bcc\u7684\u5275\u65b0\u85e5\u7522\u54c1\u7ba1\u7dda\uff0c\u5305\u62ec\u6291\u5236Bcl-2\u3001IAP \u6216\u00a0MDM2-p53 \u7b49\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u7684\u6291\u5236\u5291\uff1b\u65b0\u4e00\u4ee3\u91dd\u5c0d\u764c\u75c7\u6cbb\u7642\u4e2d\u51fa\u73fe\u7684\u6fc0\u9176\u7a81\u8b8a\u9ad4\u7684\u6291\u5236\u5291\u7b49\uff0c\u70ba\u5168\u7403\u552f\u4e00\u5728\u7d30\u80de\u51cb\u4ea1\u901a\u8def\u95dc\u9375\u86cb\u767d\u9818\u57df\u5747\u6709\u81e8\u5e8a\u958b\u767c\u54c1\u7a2e\u7684\u5275\u65b0\u516c\u53f8\u3002\u76ee\u524d\u516c\u53f8\u5df2\u5728\u4e2d\u570b\u3001\u7f8e\u570b\u3001\u6fb3\u5927\u5229\u4e9e\u53ca\u6b50\u6d32\u958b\u5c5540\u591a\u9805\u81e8\u5e8a\u8a66\u9a57\uff0c\u5176\u4e2d\u5305\u62ec13\u9805\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08\u5df2\u5b8c\u6210\/\u9032\u884c\u4e2d\/\u64ec\u555f\u52d5\uff09\u3002<\/p>\n

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        \u524d\u77bb\u6027\u8072\u660e<\/u><\/b><\/p>\n

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Institute\uff09\u3001\u7f8e\u570b\u570b\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u548c\u5bc6\u897f\u6839\u5927\u5b78\u7b49\u5b78\u8853\u6a5f\u69cb\u9054\u6210\u5168\u7403\u5408\u4f5c\u95dc\u4fc2\u3002 \u4e9e\u76db\u91ab\u85e5\u5df2\u69cb\u5efa\u5728\u539f\u5275\u65b0\u85e5\u7814\u767c\u8207\u81e8\u5e8a\u958b\u767c\u9818\u57df\u7d93\u9a57\u8c50\u5bcc\u7684\u570b\u969b\u5316\u4eba\u624d\u5718\u968a\uff0c\u4ee5\u53ca\u6210\u719f\u7684\u5546\u696d\u5316\u751f\u7522\u8207\u5e02\u5834\u71df\u92b7\u5718\u968a\u3002\u4e9e\u76db\u91ab\u85e5\u5c07\u4e0d\u65b7\u63d0\u9ad8\u7814\u767c\u80fd\u529b\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u7522\u54c1\u7ba1\u7dda\u7684\u81e8\u5e8a\u958b\u767c\u9032\u5ea6\uff0c\u771f\u6b63\u8e10\u884c\u300c\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u300d\u7684\u4f7f\u547d\uff0c\u4ee5\u9020\u798f\u66f4\u591a\u60a3\u8005\u3002 \u524d\u77bb\u6027\u8072\u660e \u672c\u6587\u6240\u4f5c\u51fa\u7684\u524d\u77bb\u6027\u9673\u8ff0\u50c5\u8207\u672c\u6587\u4f5c\u51fa\u8a72\u9673\u8ff0\u7576\u65e5\u7684\u4e8b\u4ef6\u6216\u8cc7\u6599\u6709\u95dc\u3002\u9664\u6cd5\u5f8b\u898f\u5b9a\u5916\uff0c\u65bc\u4f5c\u51fa\u524d\u77bb\u6027\u9673\u8ff0\u7576\u65e5\u4e4b\u5f8c\uff0c\u7121\u8ad6\u662f\u5426\u51fa\u73fe\u65b0\u8cc7\u6599\u3001\u672a\u4f86\u4e8b\u4ef6\u6216\u5176\u4ed6\u60c5\u6cc1\uff0c\u6211\u5011\u4e26\u7121\u8cac\u4efb\u66f4\u65b0\u6216\u516c\u958b\u4fee\u6539\u4efb\u4f55\u524d\u77bb\u6027\u9673\u8ff0\u53ca\u9810\u6599\u4e4b\u5916\u7684\u4e8b\u4ef6\u3002\u8acb\u7d30\u95b1\u672c\u6587\uff0c\u4e26\u7406\u89e3\u6211\u5011\u7684\u5be6\u969b\u672a\u4f86\u696d\u7e3e\u6216\u8868\u73fe\u53ef\u80fd\u8207\u9810\u671f\u6709\u91cd\u5927\u5dee\u7570\u3002\u672c\u6587\u5167\u6240\u6709\u9673\u8ff0\u4e43\u672c\u6587\u7ae0\u520a\u767c\u65e5\u671f\u4f5c\u51fa\uff0c\u53ef\u80fd\u56e0\u672a\u4f86\u767c\u5c55\u800c\u51fa\u73fe\u8b8a\u52d5\u3002\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pingtungtimes.com.tw\/?p=282955\" \/>\n<meta property=\"og:locale\" content=\"zh_TW\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u3010\u76f4\u64caASH 2024\u3011\u4e2d\u4f4dPFS\u8d859\u500b\u6708\uff01\u4e9e\u76db\u91ab\u85e5Bcl-2\u6291\u5236\u5291APG-2575\u53e3\u982d\u5831\u544a\u5c55\u793a\u6cbb\u7642R\/R MM\u60a3\u8005\u512a\u79c0\u6578\u64da - \u5c4f\u6771\u6642\u5831\u96fb\u5b50\u5831\" \/>\n<meta property=\"og:description\" content=\"\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde2024\u5e7412\u670810\u65e5 \/\u7f8e\u901a\u793e\/ -- \u81f4\u529b\u65bc\u5728\u816b\u7624\u7b49\u9818\u57df\u958b\u767c\u5275\u65b0\u85e5\u7269\u7684\u9818\u5148\u7684\u751f\u7269\u91ab\u85e5\u4f01\u696d\u2014\u2014\u4e9e\u76db\u91ab\u85e5\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u4f48\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u570b\u8056\u5730\u4e9e\u54e5\u8209\u8fa6\u7684\u7b2c66\u5c46\u7f8e\u570b\u8840\u6db2\u5b78\u6703\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u53e3\u982d\u5831\u544a\u4e86\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291APG-2575\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u3002\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u7684Sikander Ailawadhi\u6559\u6388\u548cAsher A. Chanan-Khan\u6559\u6388\u70ba\u8a72\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u00ae\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u53e3\u982d\u5831\u544a\u4e2d\u6240\u5c55\u793a\u7684\u95dc\u65bcAPG-2575\u6cbb\u7642R\/R MM\u7684\u7814\u7a76\u7d50\u679c\uff0c\u9032\u4e00\u6b65\u9ad4\u73fe\u51fa\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u7684\u5f37\u52c1\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\u3002\u6578\u64da\u986f\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u768436\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7e3d\u53cd\u61c9\u7387\uff08ORR\uff09\u905463.9%\uff0c\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\u7387\u905430.6%\uff0c\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9ad8\u90549.7\u6708\uff1b\u800c\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cAPG-2575\u5728800-1200mg\u5291\u91cf\u4e0b\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\u6642\u4ecd\u5448\u73fe\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e14\u5747\u672a\u767c\u751f\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u3002\u9019\u662f\u7b2c\u4e00\u500bBcl-2\u6291\u5236\u5291\u5728\u9ad8\u5291\u91cf\u4e0b\u9577\u6642\u9593\u4f7f\u7528\u7684\u7814\u7a76\u5831\u544a\u3002 Sikander Ailawadhi\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u7684R\/R MM\u60a3\u8005\u4e2d\uff0cAPG-2575\u806f\u5408Pd\u65b9\u6848\u986f\u793a\u4e86\u66f4\u9ad8\u7684\u7de9\u89e3\u7387\u548c\u66f4\u9577\u7684\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff0c\u5176\u4e2d\u4e5f\u5305\u62ec\u6297CD38\u6297\u9ad4\u85e5\u7269\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u7814\u7a76\u4e2d\uff0c\u57fa\u65bcAPG-2575\u7684\u7642\u6cd5\u986f\u793a\u4e86\u5f88\u597d\u7684\u5b89\u5168\u6027\uff0c\u5373\u4f7f\u7814\u7a76\u63a1\u7528\u4e86\u8f03\u9ad8\u7684\u5291\u91cf\u3002\u9019\u610f\u5473\u8457\u8a72\u85e5\u7269\u6709\u671b\u70baR\/R MM\u60a3\u8005\u5e36\u4f86\u4e00\u6b3e\u6709\u6548\u7684\u9776\u5411\u7642\u6cd5\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208APG-2575\u91dd\u5c0dR\/R MM\u7684\u7814\u7a76\u6210\u679c\u80fd\u7372\u5165\u9078\u53e3\u982d\u5831\u544a\uff0c\u5728ASH\u5e74\u6703\u4e0a\u518d\u6b21\u9a57\u8b49\u4e86\u9019\u4e00\u5168\u7403'Best-in-class'\u6f5b\u529b\u54c1\u7a2e\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002MM\u6cbb\u7642\u9818\u57df\u8fd1\u5e74\u4f86\u96d6\u7136\u6709\u5f88\u591a\u9032\u5c55\uff0c\u4f46\u662f\u5fa9\u767c\u96e3\u6cbb,\u7279\u5225\u662f\u7d93\u904e\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u3001\u514d\u75ab\u8abf\u7bc0\u5291CD38\u55ae\u6297\u5747\u6cbb\u7642\u5931\u6557\u7684MM\uff0c\u4ecd\u7136\u662f\u5f37\u70c8\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-2575\u5728\u591a\u7a2e\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u7624\u6cbb\u7642\u9818\u57df\u5177\u5099\u5ee3\u95ca\u7684\u6cbb\u7642\u524d\u666f\uff0c\u5176\u91dd\u5c0dR\/R\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u53d7\u7406\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (pts) with Relapsed or Refractory Multiple Myeloma (R\/R MM) or Immunoglobulin Light-Chain (AL) Amyloidosis Lisaftoclax\uff08APG-2575\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08R\/R MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\uff08pts\uff09 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a1022\u5206\u6703\u5834\uff1a654. \u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff1a\u85e5\u7269\u7642\u6cd5\uff1a\u672a\u4f86\u5c55\u671b\uff1a\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u65b0\u85e5\u548c\u806f\u5408\u7642\u6cd5 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a MM\u7684\u7279\u5fb5\u662f\u7570\u5e38\u6f3f\u7d30\u80de\u514b\u9686\u589e\u6b96\uff0c\u5c0e\u81f4\u7834\u58de\u6027\u9aa8\u75c5\u8b8a\u3001\u814e\u640d\u50b7\u3001\u8ca7\u8840\u548c\u9ad8\u9223\u8840\u75c7\u3002MM\u7684\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u514d\u75ab\u8abf\u7bc0\u5291\u3001\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u548c\u6297CD38\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u4ee5\u9054\u5230\u75be\u75c5\u7de9\u89e3\u7684\u76ee\u7684\u3002 AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7d30\u80de\u5916\u932f\u8aa4\u6298\u758a\u86cb\u767d\u7570\u5e38\u6c89\u7a4d\u65bc\u5404\u5668\u5b98\u4e26\u9020\u6210\u640d\u5bb3\u7684\u75be\u75c5\uff0c\u4e3b\u8981\u6cbb\u7642\u7b56\u7565\u662f\u63a8\u9072\u5668\u5b98\u529f\u80fd\u969c\u7919\u7684\u6642\u9593\u6216\u9006\u8f49\u5668\u5b98\u529f\u80fd\u969c\u7919\u3002\u7136\u800c\uff0c\u8a31\u591a\u60a3\u8005\u5728\u63a5\u53d7\u6a19\u6e96\u7684\u4e09\u806f\u6216\u56db\u806f\u7642\u6cd5\u5f8c\u6703\u51fa\u73fe\u5fa9\u767c\uff0c\u9019\u5c31\u9700\u8981\u63a1\u7528\u5177\u6709\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u5176\u4ed6\u7642\u6cd5\u3002 APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u65b0\u578bBcl-2\u6291\u5236\u5291\uff0c\u5728\u524d\u671f\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u5f88\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u6b64\uff0c\u6211\u5011\u5831\u544a\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u5728R\/R MM\u6216R\/R 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Sikander Ailawadhi\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u7684R\\\/R MM\u60a3\u8005\u4e2d\uff0cAPG-2575\u806f\u5408Pd\u65b9\u6848\u986f\u793a\u4e86\u66f4\u9ad8\u7684\u7de9\u89e3\u7387\u548c\u66f4\u9577\u7684\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff0c\u5176\u4e2d\u4e5f\u5305\u62ec\u6297CD38\u6297\u9ad4\u85e5\u7269\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u7814\u7a76\u4e2d\uff0c\u57fa\u65bcAPG-2575\u7684\u7642\u6cd5\u986f\u793a\u4e86\u5f88\u597d\u7684\u5b89\u5168\u6027\uff0c\u5373\u4f7f\u7814\u7a76\u63a1\u7528\u4e86\u8f03\u9ad8\u7684\u5291\u91cf\u3002\u9019\u610f\u5473\u8457\u8a72\u85e5\u7269\u6709\u671b\u70baR\\\/R MM\u60a3\u8005\u5e36\u4f86\u4e00\u6b3e\u6709\u6548\u7684\u9776\u5411\u7642\u6cd5\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208APG-2575\u91dd\u5c0dR\\\/R MM\u7684\u7814\u7a76\u6210\u679c\u80fd\u7372\u5165\u9078\u53e3\u982d\u5831\u544a\uff0c\u5728ASH\u5e74\u6703\u4e0a\u518d\u6b21\u9a57\u8b49\u4e86\u9019\u4e00\u5168\u7403'Best-in-class'\u6f5b\u529b\u54c1\u7a2e\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002MM\u6cbb\u7642\u9818\u57df\u8fd1\u5e74\u4f86\u96d6\u7136\u6709\u5f88\u591a\u9032\u5c55\uff0c\u4f46\u662f\u5fa9\u767c\u96e3\u6cbb,\u7279\u5225\u662f\u7d93\u904e\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u3001\u514d\u75ab\u8abf\u7bc0\u5291CD38\u55ae\u6297\u5747\u6cbb\u7642\u5931\u6557\u7684MM\uff0c\u4ecd\u7136\u662f\u5f37\u70c8\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-2575\u5728\u591a\u7a2e\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u7624\u6cbb\u7642\u9818\u57df\u5177\u5099\u5ee3\u95ca\u7684\u6cbb\u7642\u524d\u666f\uff0c\u5176\u91dd\u5c0dR\\\/R\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\\\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u53d7\u7406\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (pts) with Relapsed or Refractory Multiple Myeloma (R\\\/R MM) or Immunoglobulin Light-Chain (AL) Amyloidosis Lisaftoclax\uff08APG-2575\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\\\/\u96e3\u6cbb\u6027\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08R\\\/R MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\uff08pts\uff09 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a1022\u5206\u6703\u5834\uff1a654. \u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff1a\u85e5\u7269\u7642\u6cd5\uff1a\u672a\u4f86\u5c55\u671b\uff1a\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u65b0\u85e5\u548c\u806f\u5408\u7642\u6cd5 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a MM\u7684\u7279\u5fb5\u662f\u7570\u5e38\u6f3f\u7d30\u80de\u514b\u9686\u589e\u6b96\uff0c\u5c0e\u81f4\u7834\u58de\u6027\u9aa8\u75c5\u8b8a\u3001\u814e\u640d\u50b7\u3001\u8ca7\u8840\u548c\u9ad8\u9223\u8840\u75c7\u3002MM\u7684\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u514d\u75ab\u8abf\u7bc0\u5291\u3001\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u548c\u6297CD38\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u4ee5\u9054\u5230\u75be\u75c5\u7de9\u89e3\u7684\u76ee\u7684\u3002 AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7d30\u80de\u5916\u932f\u8aa4\u6298\u758a\u86cb\u767d\u7570\u5e38\u6c89\u7a4d\u65bc\u5404\u5668\u5b98\u4e26\u9020\u6210\u640d\u5bb3\u7684\u75be\u75c5\uff0c\u4e3b\u8981\u6cbb\u7642\u7b56\u7565\u662f\u63a8\u9072\u5668\u5b98\u529f\u80fd\u969c\u7919\u7684\u6642\u9593\u6216\u9006\u8f49\u5668\u5b98\u529f\u80fd\u969c\u7919\u3002\u7136\u800c\uff0c\u8a31\u591a\u60a3\u8005\u5728\u63a5\u53d7\u6a19\u6e96\u7684\u4e09\u806f\u6216\u56db\u806f\u7642\u6cd5\u5f8c\u6703\u51fa\u73fe\u5fa9\u767c\uff0c\u9019\u5c31\u9700\u8981\u63a1\u7528\u5177\u6709\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u5176\u4ed6\u7642\u6cd5\u3002 APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u65b0\u578bBcl-2\u6291\u5236\u5291\uff0c\u5728\u524d\u671f\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u5f88\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u6b64\uff0c\u6211\u5011\u5831\u544a\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u5728R\\\/R MM\u6216R\\\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u9019\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\\\/II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u9700 ECOG\u8a55\u5206 \u2264 2\uff0c\u65e2\u5f80\u63a5\u53d7\u904e\u2265 1\u7a2e\u6cbb\u7642\uff0c\u4e14\u5668\u5b98\u529f\u80fd\u6b63\u5e38\u3002R\\\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u5df2\u78ba\u8a3a\u6709\u75c7\u72c0\u7684\u5668\u5b98\u53d7\u7d2f\u3002APG-2575\uff08Lisaftoclax\uff09\u6bcf\u65e5\u53e3\u670d\uff0c\u4ee528\u5929\u70ba\u9031\u671f\u91cd\u8907\u7d66\u85e5\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u548c\u4f86\u90a3\u5ea6\u80fa\u6309\u8aaa\u660e\u66f8\u7528\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e 40 mg\uff0820 mg\uff0c\u5e74\u9f61>75\u6b72\uff09\u572828\u5929\u9031\u671f\u7684\u7b2c1\u30018\u300115\u548c22\u5929\u7d66\u85e5\u3002 \u9019\u9805\u7814\u7a76\u8a55\u4f30\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u6cca\u99ac\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u6cbb\u7642R\\\/R MM\u60a3\u8005\uff08Pd\uff1b\u6cbb\u7642\u7d44A\uff09\uff1b\u806f\u5408\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u3001\u4f86\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u6cbb\u7642R\\\/R MM\u60a3\u8005\uff08DRd\uff1b\u6cbb\u7642\u7d44B\uff09\uff1b\u806f\u5408Pd\u65b9\u6848\u6cbb\u7642R\\\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\uff08\u6cbb\u7642\u7d44C\uff09\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u622a\u81f32024\u5e7411\u67085\u65e5\uff0c\u5171\u670958\u4f8b\u60a3\u8005\u5165\u7d44\uff0c\u5176\u4e2d\u5305\u62ec48\u4f8bR\\\/R MM\u60a3\u8005\u548c10\u4f8bAL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u3002 \u5728A\u7d44\uff08n=41\uff09\u4e2d\uff0cAPG-2575\uff08Lisaftoclax\uff09\u6309\u6307\u5b9a\u5291\u91cf\u53e3\u670d\u7d66\u85e5\uff1a400mg\uff083\u4f8b\uff09\u3001600mg\uff084\u4f8b\uff09\u3001800mg\uff0815\u4f8b\uff09\u30011,000mg\uff0813\u4f8b\uff09\u548c1,200mg\uff086\u4f8b\uff09\u3002\u5728B\u7d44\uff08n=7\uff09\u4e2d\uff0c\u6240\u6709\u60a3\u8005\u90fd\u63a5\u53d7\u4e86600mg APG-2575\uff08Lisaftoclax\uff09\u7684\u6cbb\u7642\u3002\u5728 C \u7d44\uff08n=10\uff09\u4e2d\uff0c\u7d66\u85e5\u5291\u91cf\u5206\u5225\u70ba400 mg\uff081\u4f8b\uff09\u3001600 mg\uff084\u4f8b\uff09\u3001800 mg\uff083\u4f8b\uff09\u548c 1,000 mg\uff082\u4f8b\uff09\u3002 \u7642\u6548\u6578\u64da\uff1a A \u7d4436\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u67093\u4f8b\uff088.3%\uff09\u9054\u5230\u4e86\u5b8c\u5168\u7de9\u89e3\uff08CR\uff09\uff0c8\u4f8b\uff0822.2%\uff09\u9054\u5230VGPR\uff0c12\u4f8b\uff0833.3%\uff09\u9054\u5230\u90e8\u5206\u7de9\u89e3 (PR)\u3002ORR\u70ba63.9%\uff0823\u4f8b\uff09\uff0c11\u4f8b\uff0830.6%\uff09\u9054\u5230\u2265 VGPR\u3002 B\u7d445\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u67092\u4f8b\uff0840%\uff09\u9054\u5230CR\u3002 C\u7d449\u4f8b\u63a5\u53d7\u8a55\u4f30\u7684\u60a3\u8005\u4e2d\uff0c1\u4f8b\uff0811.1%\uff09\u9054\u5230CR\uff0c6\u4f8b\uff0866.7%\uff09\u9054\u5230 VGPR\uff0cORR \u70ba 88.9%\uff088\u4f8b\uff09\uff1b2\u4f8b\u7372\u5f97\u5fc3\u81df\u53cd\u61c9\u3002 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MM\u7684\u7814\u7a76\u6210\u679c\u80fd\u7372\u5165\u9078\u53e3\u982d\u5831\u544a\uff0c\u5728ASH\u5e74\u6703\u4e0a\u518d\u6b21\u9a57\u8b49\u4e86\u9019\u4e00\u5168\u7403'Best-in-class'\u6f5b\u529b\u54c1\u7a2e\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002MM\u6cbb\u7642\u9818\u57df\u8fd1\u5e74\u4f86\u96d6\u7136\u6709\u5f88\u591a\u9032\u5c55\uff0c\u4f46\u662f\u5fa9\u767c\u96e3\u6cbb,\u7279\u5225\u662f\u7d93\u904e\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u3001\u514d\u75ab\u8abf\u7bc0\u5291CD38\u55ae\u6297\u5747\u6cbb\u7642\u5931\u6557\u7684MM\uff0c\u4ecd\u7136\u662f\u5f37\u70c8\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-2575\u5728\u591a\u7a2e\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u7624\u6cbb\u7642\u9818\u57df\u5177\u5099\u5ee3\u95ca\u7684\u6cbb\u7642\u524d\u666f\uff0c\u5176\u91dd\u5c0dR\/R\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u53d7\u7406\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (pts) with Relapsed or Refractory Multiple Myeloma (R\/R MM) or Immunoglobulin Light-Chain (AL) Amyloidosis Lisaftoclax\uff08APG-2575\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08R\/R MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\uff08pts\uff09 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a1022\u5206\u6703\u5834\uff1a654. \u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff1a\u85e5\u7269\u7642\u6cd5\uff1a\u672a\u4f86\u5c55\u671b\uff1a\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u65b0\u85e5\u548c\u806f\u5408\u7642\u6cd5 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a MM\u7684\u7279\u5fb5\u662f\u7570\u5e38\u6f3f\u7d30\u80de\u514b\u9686\u589e\u6b96\uff0c\u5c0e\u81f4\u7834\u58de\u6027\u9aa8\u75c5\u8b8a\u3001\u814e\u640d\u50b7\u3001\u8ca7\u8840\u548c\u9ad8\u9223\u8840\u75c7\u3002MM\u7684\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u514d\u75ab\u8abf\u7bc0\u5291\u3001\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u548c\u6297CD38\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u4ee5\u9054\u5230\u75be\u75c5\u7de9\u89e3\u7684\u76ee\u7684\u3002 AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7d30\u80de\u5916\u932f\u8aa4\u6298\u758a\u86cb\u767d\u7570\u5e38\u6c89\u7a4d\u65bc\u5404\u5668\u5b98\u4e26\u9020\u6210\u640d\u5bb3\u7684\u75be\u75c5\uff0c\u4e3b\u8981\u6cbb\u7642\u7b56\u7565\u662f\u63a8\u9072\u5668\u5b98\u529f\u80fd\u969c\u7919\u7684\u6642\u9593\u6216\u9006\u8f49\u5668\u5b98\u529f\u80fd\u969c\u7919\u3002\u7136\u800c\uff0c\u8a31\u591a\u60a3\u8005\u5728\u63a5\u53d7\u6a19\u6e96\u7684\u4e09\u806f\u6216\u56db\u806f\u7642\u6cd5\u5f8c\u6703\u51fa\u73fe\u5fa9\u767c\uff0c\u9019\u5c31\u9700\u8981\u63a1\u7528\u5177\u6709\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u5176\u4ed6\u7642\u6cd5\u3002 APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u65b0\u578bBcl-2\u6291\u5236\u5291\uff0c\u5728\u524d\u671f\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u5f88\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u6b64\uff0c\u6211\u5011\u5831\u544a\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u5728R\/R MM\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u9019\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u9700 ECOG\u8a55\u5206 \u2264 2\uff0c\u65e2\u5f80\u63a5\u53d7\u904e\u2265 1\u7a2e\u6cbb\u7642\uff0c\u4e14\u5668\u5b98\u529f\u80fd\u6b63\u5e38\u3002R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u5df2\u78ba\u8a3a\u6709\u75c7\u72c0\u7684\u5668\u5b98\u53d7\u7d2f\u3002APG-2575\uff08Lisaftoclax\uff09\u6bcf\u65e5\u53e3\u670d\uff0c\u4ee528\u5929\u70ba\u9031\u671f\u91cd\u8907\u7d66\u85e5\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u548c\u4f86\u90a3\u5ea6\u80fa\u6309\u8aaa\u660e\u66f8\u7528\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e 40 mg\uff0820 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Hematology\uff0cASH\uff09\u5e74\u6703\u4e0a\uff0c\u53e3\u982d\u5831\u544a\u4e86\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u65b0\u578b\u9078\u64c7\u6027Bcl-2\u6291\u5236\u5291APG-2575\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\uff08R\/R\uff09\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u7684\u6700\u65b0\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u3002\u6885\u5967\u91ab\u5b78\u4e2d\u5fc3\u7684Sikander Ailawadhi\u6559\u6388\u548cAsher A. Chanan-Khan\u6559\u6388\u70ba\u8a72\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\u3002 ASH\u5e74\u6703\u662f\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u898f\u6a21\u6700\u5927\u7684\u570b\u969b\u5b78\u8853\u76db\u6703\u4e4b\u4e00\uff0c\u5f59\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u9032\u5c55\u53ca\u6700\u65b0\u7684\u85e5\u7269\u7814\u767c\u6578\u64da\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b78\u9818\u57df\u7684\u6700\u9ad8\u5b78\u8853\u6c34\u5e73\u3002\u4f5c\u70ba\u65e5\u76ca\u6d3b\u8e8d\u5728\u570b\u969b\u5b78\u8853\u821e\u53f0\u4e0a\u7684\u300c\u4e2d\u570b\u8072\u97f3\u300d\uff0c\u4eca\u5e74\u4e9e\u76db\u91ab\u85e5\u56db\u500b\u54c1\u7a2e\uff08\u8010\u7acb\u514b\u00ae\u3001APG-2575\u3001APG-2449\u3001APG-5918\uff09\u6709\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u9032\u5c55\u5165\u9078ASH\u5e74\u6703\u5c55\u793a\u53ca\u5831\u544a\uff0c\u5176\u4e2d\u5169\u9805\u7372\u53e3\u982d\u5831\u544a\u3002 \u6b64\u6b21\u53e3\u982d\u5831\u544a\u4e2d\u6240\u5c55\u793a\u7684\u95dc\u65bcAPG-2575\u6cbb\u7642R\/R MM\u7684\u7814\u7a76\u7d50\u679c\uff0c\u9032\u4e00\u6b65\u9ad4\u73fe\u51fa\u8a72\u54c1\u7a2e\u806f\u5408\u6cbb\u7642\u7684\u5f37\u52c1\u7642\u6548\u548c\u5b89\u5168\u6027\u512a\u52e2\u3002\u6578\u64da\u986f\u793a\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u768436\u4f8b\u53ef\u8a55\u4f30\u60a3\u8005\u4e2d\uff0c\u7e3d\u53cd\u61c9\u7387\uff08ORR\uff09\u905463.9%\uff0c\u975e\u5e38\u597d\u7684\u90e8\u5206\u7de9\u89e3\uff08VGPR\uff09\u7387\u905430.6%\uff0c\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u9ad8\u90549.7\u6708\uff1b\u800c\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cAPG-2575\u5728800-1200mg\u5291\u91cf\u4e0b\u8207\u5176\u4ed6\u85e5\u7269\u806f\u7528\u6642\u4ecd\u5448\u73fe\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e14\u5747\u672a\u767c\u751f\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u3002\u9019\u662f\u7b2c\u4e00\u500bBcl-2\u6291\u5236\u5291\u5728\u9ad8\u5291\u91cf\u4e0b\u9577\u6642\u9593\u4f7f\u7528\u7684\u7814\u7a76\u5831\u544a\u3002 Sikander Ailawadhi\u6559\u6388\u8868\u793a\uff1a\u300c\u5728\u65e2\u5f80\u63a5\u53d7\u904e\u591a\u7dda\u6cbb\u7642\u7684R\/R MM\u60a3\u8005\u4e2d\uff0cAPG-2575\u806f\u5408Pd\u65b9\u6848\u986f\u793a\u4e86\u66f4\u9ad8\u7684\u7de9\u89e3\u7387\u548c\u66f4\u9577\u7684\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff0c\u5176\u4e2d\u4e5f\u5305\u62ec\u6297CD38\u6297\u9ad4\u85e5\u7269\u96e3\u6cbb\u7684\u60a3\u8005\u3002\u7814\u7a76\u4e2d\uff0c\u57fa\u65bcAPG-2575\u7684\u7642\u6cd5\u986f\u793a\u4e86\u5f88\u597d\u7684\u5b89\u5168\u6027\uff0c\u5373\u4f7f\u7814\u7a76\u63a1\u7528\u4e86\u8f03\u9ad8\u7684\u5291\u91cf\u3002\u9019\u610f\u5473\u8457\u8a72\u85e5\u7269\u6709\u671b\u70baR\/R MM\u60a3\u8005\u5e36\u4f86\u4e00\u6b3e\u6709\u6548\u7684\u9776\u5411\u7642\u6cd5\u3002\u300d \u4e9e\u76db\u91ab\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208APG-2575\u91dd\u5c0dR\/R MM\u7684\u7814\u7a76\u6210\u679c\u80fd\u7372\u5165\u9078\u53e3\u982d\u5831\u544a\uff0c\u5728ASH\u5e74\u6703\u4e0a\u518d\u6b21\u9a57\u8b49\u4e86\u9019\u4e00\u5168\u7403'Best-in-class'\u6f5b\u529b\u54c1\u7a2e\u5353\u8d8a\u7684\u5b89\u5168\u6027\u548c\u7642\u6548\u3002MM\u6cbb\u7642\u9818\u57df\u8fd1\u5e74\u4f86\u96d6\u7136\u6709\u5f88\u591a\u9032\u5c55\uff0c\u4f46\u662f\u5fa9\u767c\u96e3\u6cbb,\u7279\u5225\u662f\u7d93\u904e\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u3001\u514d\u75ab\u8abf\u7bc0\u5291CD38\u55ae\u6297\u5747\u6cbb\u7642\u5931\u6557\u7684MM\uff0c\u4ecd\u7136\u662f\u5f37\u70c8\u7684\u672a\u6eff\u8db3\u81e8\u5e8a\u9700\u6c42\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cAPG-2575\u5728\u591a\u7a2e\u8840\u6db2\u816b\u7624\u548c\u5be6\u9ad4\u7624\u6cbb\u7642\u9818\u57df\u5177\u5099\u5ee3\u95ca\u7684\u6cbb\u7642\u524d\u666f\uff0c\u5176\u91dd\u5c0dR\/R\u6162\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u570b\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u5df2\u65bc\u8fd1\u65e5\u7372\u53d7\u7406\u4e26\u7d0d\u5165\u512a\u5148\u5be9\u8a55\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u5805\u5b88'\u89e3\u6c7a\u4e2d\u570b\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42'\u9019\u4e00\u4f7f\u547d\uff0c\u52a0\u901f\u63a8\u9032\u516c\u53f8\u91cd\u9ede\u54c1\u7a2e\u5728\u5168\u7403\u5c64\u9762\u7684\u81e8\u5e8a\u958b\u767c\uff0c\u8b93\u66f4\u591a\u5b89\u5168\u6709\u6548\u7684\u85e5\u7269\u76e1\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u300d \u6b64\u9805\u7814\u7a76\u57282024 ASH\u5e74\u6703\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u9ede\u5982\u4e0b\uff1a Lisaftoclax (APG-2575) Combined with Novel Therapeutic Regimens in Patients (pts) with Relapsed or Refractory Multiple Myeloma (R\/R MM) or Immunoglobulin Light-Chain (AL) Amyloidosis Lisaftoclax\uff08APG-2575\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u7528\u65bc\u5fa9\u767c\/\u96e3\u6cbb\u6027\u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff08R\/R MM\uff09\u6216\u514d\u75ab\u7403\u86cb\u767d\u8f15\u93c8\uff08AL\uff09\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\uff08pts\uff09 \u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u982d\u5831\u544a\u6458\u8981\u7de8\u865f\uff1a1022\u5206\u6703\u5834\uff1a654. \u591a\u767c\u6027\u9aa8\u9ad3\u7624\uff1a\u85e5\u7269\u7642\u6cd5\uff1a\u672a\u4f86\u5c55\u671b\uff1a\u7528\u65bc\u6cbb\u7642\u591a\u767c\u6027\u9aa8\u9ad3\u7624\u7684\u65b0\u85e5\u548c\u806f\u5408\u7642\u6cd5 \u6838\u5fc3\u8981\u9ede\uff1a \u7814\u7a76\u80cc\u666f\uff1a MM\u7684\u7279\u5fb5\u662f\u7570\u5e38\u6f3f\u7d30\u80de\u514b\u9686\u589e\u6b96\uff0c\u5c0e\u81f4\u7834\u58de\u6027\u9aa8\u75c5\u8b8a\u3001\u814e\u640d\u50b7\u3001\u8ca7\u8840\u548c\u9ad8\u9223\u8840\u75c7\u3002MM\u7684\u6cbb\u7642\u65b9\u6cd5\u5305\u62ec\u4f7f\u7528\u514d\u75ab\u8abf\u7bc0\u5291\u3001\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\u548c\u6297CD38\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u4ee5\u9054\u5230\u75be\u75c5\u7de9\u89e3\u7684\u76ee\u7684\u3002 AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u662f\u4e00\u7a2e\u7d30\u80de\u5916\u932f\u8aa4\u6298\u758a\u86cb\u767d\u7570\u5e38\u6c89\u7a4d\u65bc\u5404\u5668\u5b98\u4e26\u9020\u6210\u640d\u5bb3\u7684\u75be\u75c5\uff0c\u4e3b\u8981\u6cbb\u7642\u7b56\u7565\u662f\u63a8\u9072\u5668\u5b98\u529f\u80fd\u969c\u7919\u7684\u6642\u9593\u6216\u9006\u8f49\u5668\u5b98\u529f\u80fd\u969c\u7919\u3002\u7136\u800c\uff0c\u8a31\u591a\u60a3\u8005\u5728\u63a5\u53d7\u6a19\u6e96\u7684\u4e09\u806f\u6216\u56db\u806f\u7642\u6cd5\u5f8c\u6703\u51fa\u73fe\u5fa9\u767c\uff0c\u9019\u5c31\u9700\u8981\u63a1\u7528\u5177\u6709\u65b0\u4f5c\u7528\u6a5f\u5236\u7684\u5176\u4ed6\u7642\u6cd5\u3002 APG-2575\uff08Lisaftoclax\uff09\u662f\u4e00\u7a2e\u65b0\u578bBcl-2\u6291\u5236\u5291\uff0c\u5728\u524d\u671f\u7814\u7a76\u4e2d\u986f\u793a\u51fa\u5f88\u5f37\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u5728\u6b64\uff0c\u6211\u5011\u5831\u544a\u4e86APG-2575\uff08Lisaftoclax\uff09\u806f\u5408\u65b0\u578b\u6cbb\u7642\u65b9\u6848\u5728R\/R MM\u6216R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u4e2d\u7684\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u3002 \u7814\u7a76\u4ecb\u7d39\uff1a\u9019\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027I\/II\u671f\u81e8\u5e8a\u7814\u7a76\u3002 \u5165\u7d44\u60a3\u8005\u548c\u7814\u7a76\u65b9\u6cd5\uff1a \u7b26\u5408\u689d\u4ef6\u7684\u60a3\u8005\u9700 ECOG\u8a55\u5206 \u2264 2\uff0c\u65e2\u5f80\u63a5\u53d7\u904e\u2265 1\u7a2e\u6cbb\u7642\uff0c\u4e14\u5668\u5b98\u529f\u80fd\u6b63\u5e38\u3002R\/R AL\u6fb1\u7c89\u6a23\u8b8a\u6027\u60a3\u8005\u5df2\u78ba\u8a3a\u6709\u75c7\u72c0\u7684\u5668\u5b98\u53d7\u7d2f\u3002APG-2575\uff08Lisaftoclax\uff09\u6bcf\u65e5\u53e3\u670d\uff0c\u4ee528\u5929\u70ba\u9031\u671f\u91cd\u8907\u7d66\u85e5\u3002\u6cca\u99ac\u5ea6\u80fa\u3001\u9054\u96f7\u59a5\u5c24\u55ae\u6297\u548c\u4f86\u90a3\u5ea6\u80fa\u6309\u8aaa\u660e\u66f8\u7528\u6cd5\u7d66\u85e5\u3002\u5730\u585e\u7c73\u677e 40 mg\uff0820 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